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Kristel Sleegers

Research Profile

Disorders

Physiology

Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Rita Cacace; Marc Cruts; Peter P De Deyn; L Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Maria Mattheijssens; Karin Peeters; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Julie van der Zee; Jasper Van Dongen; Rik Vandenberghe; Mathieu Vandenbulcke; Veerle Bäumer; Karolien Bettens; Kristel Sleegers
C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment.
Sylvie Slaets; Kristel Sleegers; Jessie Theuns; Christine Van Broeckhoven; Aline Verstraeten; Evelyn De Leenheir; Nathalie Le Bastard; Jill Luyckx; Jean-Jacques Martin; Sebastiaan Engelborghs
Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies.
Sebastiaan Engelborghs; Nathalie Le Bastard; Kristel Sleegers; Christine Van Broeckhoven; Stefan Van der Mussele; Nathalie Brouwers; Peter Paul De Deyn
Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.

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2013: Rita Cacace; Marc Cruts; Peter P De Deyn; L Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Maria Mattheijssens; Karin Peeters; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Julie van der Zee; Jasper Van Dongen; Rik Vandenberghe; Mathieu Vandenbulcke; Veerle Bäumer; Karolien Bettens; Kristel Sleegers
C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment.
Neurobiology of aging 2013;34(6):1712.e1-7.
2013: Sylvie Slaets; Kristel Sleegers; Jessie Theuns; Christine Van Broeckhoven; Aline Verstraeten; Evelyn De Leenheir; Nathalie Le Bastard; Jill Luyckx; Jean-Jacques Martin; Sebastiaan Engelborghs
Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies.
Journal of Alzheimer's disease : JAD 2013;35(1):137-46.
2013: Sebastiaan Engelborghs; Nathalie Le Bastard; Kristel Sleegers; Christine Van Broeckhoven; Stefan Van der Mussele; Nathalie Brouwers; Peter Paul De Deyn
Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;35(1):67-73.
2013: Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
Genetic insights in Alzheimer's disease.
Lancet neurology 2013;12(1):92-104.
2013: Nathalie Le Bastard; Jean-Jacques Martin; Kristel Sleegers; Christine Van Broeckhoven; Laetitia Aerts; Peter Paul De Deyn; Sebastiaan Engelborghs
Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33(3):807-22.
2012: Lili-Naz Hazrati; Patricia L Brooks; Nathalie Brouwers; Marc Cruts; Mahdi Ghani; Christine Sato; Kristel Sleegers; Peter St George-Hyslop; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Ekaterina Rogaeva
Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Neurobiology of aging 2012;33(12):2949.e5-2949.e12.
2012: Jessie Theuns; Ellen Corsmit; Patrick cras; David Crosiers; Peter Paul De Deyn; Luc Debaene; Jurgen Del-Favero; Ellen Elinck; Sebastiaan Engelborghs; Dirk Goossens; Maria Mattheijssens; Bram Meeus; Karen Nuytemans; Karin Peeters; Barbara A Pickut; Kristel Sleegers; Christine Van Broeckhoven
Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa-responsive dystonia.
Movement disorders : official journal of the Movement Disorder Society 2012;27(11):1451-6.
2012: Nathalie Brouwers; Marc Cruts; Sebastiaan Engelborghs; J-C Lambert; Maria Mattheijssens; A Gil Montoya; F Pasquier; Karin Peeters; Kristel Sleegers; Rik Vandenberghe; P P De Deyn; C Van Cauwenberghe; N Le Bastard; P Amouyel; K Bettens; Christine Van Broeckhoven
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
Molecular psychiatry 2012;17(2):223-33.
2012: Elke Bogaert; Robert H Brown; Peter De Jonghe; Veerle Geelen; Jonathan D Glass; An Goris; John E Landers; Robin Lemmens; Judith Melki; Wim Robberecht; Christopher E Shaw; Kristel Sleegers; Agnieszka Slowik; Vincent Timmerman; Barbara Tomik; Bryan Joseph Traynor; Christine Van Broeckhoven; Philip Van Damme; Leonard H Van den Berg; Ammar Al-Chalabi; Peter M Andersen; Anna Birve; Michael A van Es; Nathalie Verpoorten; Ludo Van Den Bosch
Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis.
Neurobiology of aging 2012;33(2):418-20.
2012: Mikael Wikgren; Rolf Adolfsson; Johan Hultdin; Thomas Karlsson; Therese Nilbrink; Lars-Göran Nilsson; Katarina Nordfjäll; Lars Nyberg; Göran Roos; Kristel Sleegers; Christine Van Broeckhoven; Karl-Fredrik Norrback
APOE ε4 is associated with longer telomeres, and longer telomeres among ε4 carriers predicts worse episodic memory.
Neurobiology of aging 2012;33(2):335-44.
2012: Mikael Wikgren; Rolf Adolfsson; Johan Hultdin; Thomas Karlsson; Johanna Lind; Therese Nilbrink; Lars-Göran Nilsson; Lars Nyberg; Göran Roos; Kristel Sleegers; Christine Van Broeckhoven; Karl-Fredrik Norrback
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
PloS one 2012;7(4):e34292.
2012: Karolien Bettens; Nathalie Brouwers; Peter P De Deyn; Sebastiaan Engelborghs; Jean-Charles Lambert; Nathalie Le Bastard; Maria Mattheijssens; Richard Mayeux; Florence Pasquier; Karin Peeters; Ekaterina Rogaeva; Kristel Sleegers; Peter St George-Hyslop; Jasper Van Dongen; Rik Vandenberghe; Steven Vermeulen; Philippe Amouyel; Christine Van Broeckhoven
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
Molecular neurodegeneration 2012;7():3.
2011: Takashi Saito; Kristel Sleegers; Takahiro Suemoto; Jiro Takano; Christine Van Broeckhoven; Kazuyuki Yamada; Nathalie Brouwers; Satoru Funamoto; Yasuo Ihara; Nobuhisa Iwata; Yukio Matsuba; Naomi Mihira; Per Nilsson; Masaki Nishimura; Takaomi C Saido
Potent amyloidogenicity and pathogenicity of Aβ43.
Nature neuroscience 2011;14(8):1023-32.
2011: Kristel Van Steen; Kristel Sleegers
A report of the first biennial meeting on Capita Selecta in Complex Disease Analysis (CSCDA2010), Leuven, Belgium, August 25-27, 2010.
Annals of human genetics 2011;75(4):554-7.
2011: Lujia Zhou; Nathalie Brouwers; Iryna Benilova; Annelies Vandersteen; Marc Mercken; Koen Van Laere; Philip Van Damme; David Demedts; Fred Van Leuven; Kristel Sleegers; Kerensa Broersen; Christine Van Broeckhoven; Rik Vandenberghe; Bart De Strooper
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
EMBO molecular medicine 2011;3(5):291-302.
2011: Sara Rollinson; Jonathan D Rohrer; Julie van der Zee; Kristel Sleegers; Simon Mead; Sebastiaan Engelborghs; John Collinge; Peter P De Deyn; David M A Mann; Christine Van Broeckhoven; Stuart Pickering-Brown
No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.
Neurobiology of aging 2011;32(4):754-5.
2011: Julie van der Zee; Tim Van Langenhove; Gernot Kleinberger; Kristel Sleegers; Sebastiaan Engelborghs; Rik Vandenberghe; Patrick Santens; Marleen Van den Broeck; Geert Joris; Jolien Brys; Maria Mattheijssens; Karin Peeters; Patrick Cras; Peter P De Deyn; Marc Cruts; Christine Van Broeckhoven
TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.
Brain : a journal of neurology 2011;134(Pt 3):808-15.
2011: Anja Capell; Sabine Liebscher; Katrin Fellerer; Nathalie Brouwers; Michael Willem; Sven Lammich; Ilse Gijselinck; Tobias Bittner; Aaron M Carlson; Florenz Sasse; Brigitte Kunze; Heinrich Steinmetz; Rolf Jansen; Dorothee Dormann; Kristel Sleegers; Marc Cruts; Jochen Herms; Christine Van Broeckhoven; Christian Haass
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1885-94.
2010: Thomas Philips; Louis De Muynck; Hoai Nguyen Thi Thu; Bea Weynants; Peter Vanacker; Joke Dhondt; Kristel Sleegers; Helenius J Schelhaas; Marcel Verbeek; Rik Vandenberghe; Raf Sciot; Christine Van Broeckhoven; Diether Lambrechts; Fred Van Leuven; Ludo Van Den Bosch; Wim Robberecht; Philip Van Damme
Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Journal of neuropathology and experimental neurology 2010;69(12):1191-200.
2010: Fan Liu; Luba M Pardo; Maaike Schuur; Pascual Sanchez-Juan; Aaron Isaacs; Kristel Sleegers; Inge de Koning; Irina V Zorkoltseva; Tatiana I Axenovich; Jacqueline C M Witteman; A Cecile J W Janssens; John C van Swieten; Yurii Aulchenko; Ben A Oostra; Cornelia M van Duijn
The apolipoprotein E gene and its age-specific effects on cognitive function.
Neurobiology of aging 2010;31(10):1831-3.
2010: Kristel Sleegers; Nathalie Brouwers; Christine Van Broeckhoven
Reply: Predicted pathogenic missense mutation of PGRN found in a normal control.
Annals of neurology 2010;68(1):119.
2010: Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
Current status on Alzheimer disease molecular genetics: from past, to present, to future.
Human molecular genetics 2010;19(R1):R4-R11.
2010: T Van Langenhove; Julie van der Zee; Kristel Sleegers; Sebastiaan Engelborghs; Rik Vandenberghe; Ilse Gijselinck; Marleen Van den Broeck; Maria Mattheijssens; Karin Peeters; Peter Paul De Deyn; Marc Cruts; Christine Van Broeckhoven
Genetic contribution of FUS to frontotemporal lobar degeneration.
Neurology 2010;74(5):366-71.
2010: Kristel Sleegers; Nathalie Brouwers; Christine Van Broeckhoven
Role of progranulin as a biomarker for Alzheimer's disease.
Biomarkers in medicine 2010;4(1):37-50.
2010: Kristel Sleegers; Jean-Charles Lambert; Lars Bertram; Marc Cruts; Philippe Amouyel; Christine Van Broeckhoven
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.
Trends in genetics : TIG 2010;26(2):84-93.
2010: Nathalie Brouwers; Karolien Bettens; Ilse Gijselinck; Sebastiaan Engelborghs; Barbara A Pickut; Helen Van Miegroet; Ana Gil Montoya; Maria Mattheijssens; Karin Peeters; Peter P De Deyn; Marc Cruts; Kristel Sleegers; Christine Van Broeckhoven
Contribution of TARDBP to Alzheimer's disease genetic etiology.
Journal of Alzheimer's disease : JAD 2010;21(2):423-30.
2010: Kristel Sleegers; Marc Cruts; Christine Van Broeckhoven
Molecular pathways of frontotemporal lobar degeneration.
Annual review of neuroscience 2010;33():71-88.
2010: Karolien Bettens; Nathalie Brouwers; Helen Van Miegroet; Ana Gil; Sebastiaan Engelborghs; Peter P De Deyn; Rik Vandenberghe; Christine Van Broeckhoven; Kristel Sleegers
Follow-up study of susceptibility loci for Alzheimer's disease and onset age identified by genome-wide association.
Journal of Alzheimer's disease : JAD 2010;19(4):1169-75.
2009: Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Tim De Pooter; Peter P De Deyn; Kristel Sleegers; Christine Van Broeckhoven
DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
Neurobiology of aging 2009;30(12):2000-9.
2009: Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Helen Van Miegroet; Peter P De Deyn; Jessie Theuns; Kristel Sleegers; Christine Van Broeckhoven
APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.
Human mutation 2009;30(8):1207-13.
2009: Ilse Gijselinck; Kristel Sleegers; Sebastiaan Engelborghs; Wim Robberecht; Jean-Jacques Martin; Rik Vandenberghe; Raf Sciot; Bart Dermaut; Dirk Goossens; Julie van der Zee; Tim De Pooter; Jurgen Del-Favero; Patrick Santens; Peter De Jonghe; Peter P De Deyn; Christine Van Broeckhoven; Marc Cruts
Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS.
Neurobiology of aging 2009;30(8):1329-31.
2009: Kristel Sleegers; Nathalie Brouwers; Philip Van Damme; Sebastiaan Engelborghs; Ilse Gijselinck; Julie van der Zee; Karin Peeters; Maria Mattheijssens; Marc Cruts; Rik Vandenberghe; Peter P De Deyn; Wim Robberecht; Christine Van Broeckhoven
Serum biomarker for progranulin-associated frontotemporal lobar degeneration.
Annals of neurology 2009;65(5):603-9.
2009: Kristel Sleegers; Nathalie Brouwers; Karolien Bettens; Sebastiaan Engelborghs; Helen van Miegroet; Peter P De Deyn; Christine Van Broeckhoven
No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.
Human mutation 2009;30(4):E570-4.
2009: Kristel Sleegers; Christine Van Broeckhoven
Motor-neuron disease: Rogue gene in the family.
Nature 2009;458(7237):415-7.
2009: Kristel Sleegers; Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Helen van Miegroet; Peter P De Deyn; Christine Van Broeckhoven
Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.
Human mutation 2009;30(2):E338-44.
2009: Fan Liu; M Arfan Ikram; A Cecile J W Janssens; Maaike Schuur; Inge de Koning; Aaron Isaacs; Maksim Struchalin; Andre G Uitterlinden; Johan T den Dunnen; Kristel Sleegers; Karolien Bettens; Christine Van Broeckhoven; John C van Swieten; Albert Hofman; Ben A Oostra; Yurii Aulchenko; Monique Breteler; Cornelia M van Duijn
A study of the SORL1 gene in Alzheimer's disease and cognitive function.
Journal of Alzheimer's disease : JAD 2009;18(1):51-64.
2008: Julie van der Zee; Kristel Sleegers; Christine Van Broeckhoven
Invited article: the Alzheimer disease-frontotemporal lobar degeneration spectrum.
Neurology 2008;71(15):1191-7.
2008: K Nuytemans; Philippe Pals; Kristel Sleegers; Sebastiaan Engelborghs; Ellen Corsmit; Karin Peeters; Barbara A Pickut; Maria Mattheijssens; Patrick Cras; Peter Paul De Deyn; Jessie Theuns; Christine Van Broeckhoven
Progranulin variability has no major role in Parkinson disease genetic etiology.
Neurology 2008;71(15):1147-51.
2008: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Sebastian Maurer-Stroh; Ilse Gijselinck; Julie van der Zee; Barbara A Pickut; Marleen Van den Broeck; Maria Mattheijssens; Karin Peeters; J Schymkowitz; Frederic Rousseau; Jean-Jacques Martin; Marc Cruts; Peter Paul De Deyn; Christine Van Broeckhoven
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Neurology 2008;71(9):656-64.
2008: Kristel Sleegers; Nathalie Brouwers; Sebastian Maurer-Stroh; M A van Es; P Van Damme; P W J van Vught; Julie van der Zee; Sally Serneels; Tim De Pooter; Marleen Van den Broeck; Marc Cruts; J Schymkowitz; Peter De Jonghe; Frederic Rousseau; L H van den Berg; Wim Robberecht; Christine Van Broeckhoven
Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Neurology 2008;71(4):253-9.
2008: Kristel Sleegers; Samir Kumar-Singh; Marc Cruts; Christine Van Broeckhoven
Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology.
Archives of neurology 2008;65(6):700-4.
2008: Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Kristel Sleegers
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.
Human mutation 2008;29(5):769-70.
2008: Alejandro Arias-Vásquez; Yurii Aulchenko; Aaron Isaacs; Andy van Oosterhout; Kristel Sleegers; Albert Hofman; Christine Van Broeckhoven; Ben A Oostra; Monique Breteler; C.M. Duijn
Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study.
Journal of neurology 2008;255(5):655-62.
2008: Nathalie Brouwers; Kristel Sleegers; Christine Van Broeckhoven
Molecular genetics of Alzheimer's disease: an update.
Annals of medicine 2008;40(8):562-83.
2008: J Persson; Johanna Lind; A Larsson; M Ingvar; Kristel Sleegers; Christine Van Broeckhoven; Rolf Adolfsson; Lars-Göran Nilsson; Lars Nyberg
Altered deactivation in individuals with genetic risk for Alzheimer's disease.
Neuropsychologia 2008;46(6):1679-87.
2008: Michael A van Es; Paul van Vught; Hylke M Blauw; Lude Franke; Christiaan G J Saris; Ludo Van Den Bosch; Sonja W de Jong; Vianney de Jong; Frank Baas; Ruben van't Slot; Robin Lemmens; H Jurgen Schelhaas; Anna Birve; Kristel Sleegers; Christine Van Broeckhoven; Jennifer C Schymick; Bryan Joseph Traynor; J H J Wokke; Cisca Wijmenga; Wim Robberecht; Peter M Andersen; Jan Veldink; Roel A Ophoff; Leonard H Van den Berg
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
Nature genetics 2008;40(1):29-31.
2007: Nathalie Brouwers; Karen Nuytemans; Julie van der Zee; Ilse Gijselinck; Sebastiaan Engelborghs; Jessie Theuns; Samir Kumar-Singh; Barbara A Pickut; Philippe Pals; Bart Dermaut; Veerle Bogaerts; Tim De Pooter; Sally Serneels; Marleen Van den Broeck; Ivy Cuijt; Maria Mattheijssens; Karin Peeters; Raf Sciot; Jean-Jacques Martin; Patrick Cras; Patrick Santens; Rik Vandenberghe; Peter Paul De Deyn; Marc Cruts; Christine Van Broeckhoven; Kristel Sleegers
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.
Archives of neurology 2007;64(10):1436-46.
2007: Michael A van Es; Paul van Vught; Hylke M Blauw; Lude Franke; Christiaan G Saris; Peter M Andersen; Ludo Van Den Bosch; Sonja W de Jong; Ruben van 't Slot; Anna Birve; Robin Lemmens; Vianney de Jong; Frank Baas; H Jurgen Schelhaas; Kristel Sleegers; Christine Van Broeckhoven; J H J Wokke; Cisca Wijmenga; Wim Robberecht; Jan Veldink; Roel A Ophoff; Leonard H Van den Berg
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.
Lancet neurology 2007;6(10):869-77.
2007: Veerle Bogaerts; Sebastiaan Engelborghs; Samir Kumar-Singh; Dirk Goossens; Barbara A Pickut; Julie van der Zee; Kristel Sleegers; Karin Peeters; Jean-Jacques Martin; Jurgen Del-Favero; Thomas Gasser; dennis dickson; Zbigniew K Wszolek; Peter Paul De Deyn; Jessie Theuns; Christine Van Broeckhoven
A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder.
Brain : a journal of neurology 2007;130(Pt 9):2277-91.
2007: Sebastiaan Engelborghs; Kristel Sleegers; Patrick Cras; Nathalie Brouwers; Sally Serneels; Evelyn De Leenheir; Jean-Jacques Martin; Eugeen Vanmechelen; Christine Van Broeckhoven; Peter Paul De Deyn
No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease.
Brain : a journal of neurology 2007;130(Pt 9):2320-6.
2007: M Axel Wollmer; Kristel Sleegers; Martin Ingelsson; Cezary Zekanowski; Nathalie Brouwers; Aleksandra Maruszak; Fabienne Brunner; Kim-Dung Huynh; Lena Kilander; Rose-Marie Brundin; Marie Hedlund; Vilmantas Giedraitis; Anna Glaser; Sebastiaan Engelborghs; Peter Paul De Deyn; Elisabeth Kapaki; Magdalini Tsolaki; Makrina Daniilidou; Dimitra Molyva; George P Paraskevas; Dietmar R Thal; Maria Barcikowska; Jacek Kuznicki; Lars Lannfelt; Christine Van Broeckhoven; Roger M Nitsch; Christoph Hock; Andreas Papassotiropoulos
Association study of cholesterol-related genes in Alzheimer's disease.
Neurogenetics 2007;8(3):179-88.
2007: Fan Liu; Alejandro Arias-Vásquez; Kristel Sleegers; Yurii Aulchenko; Manfred Kayser; Pascual Sanchez-Juan; Bing-Jian Feng; Aida M Bertoli Avella; John C van Swieten; Tatiana I Axenovich; Peter Heutink; Christine Van Broeckhoven; Ben A Oostra; C.M. Duijn
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population.
American journal of human genetics 2007;81(1):17-31.
2007: Kristel Sleegers; Inge de Koning; Yurii Aulchenko; M J E van Rijn; M P W A Houben; Esther A Croes; John C van Swieten; Ben A Oostra; C.M. Duijn
Cerebrovascular risk factors do not contribute to genetic variance of cognitive function: the ERF study.
Neurobiology of aging 2007;28(5):735-41.
2007: Julie van der Zee; Isabelle Le Ber; Sebastian Maurer-Stroh; Sebastiaan Engelborghs; Ilse Gijselinck; Agnès Camuzat; Nathalie Brouwers; Rik Vandenberghe; Kristel Sleegers; Didier Hannequin; Bart Dermaut; Joost Schymkowitz; Dominique Campion; Patrick Santens; Jean-Jacques Martin; Lucette Lacomblez; Tim De Pooter; Karin Peeters; Maria Mattheijssens; Martine Vercelletto; Marleen Van den Broeck; Marc Cruts; Peter Paul De Deyn; Frederic Rousseau; Alexis Brice; Christine Van Broeckhoven
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
Human mutation 2007;28(4):416.
2007: Cindy M de Frias; David Bunce; Ake Wahlin; Rolf Adolfsson; Kristel Sleegers; Marc Cruts; Christine Van Broeckhoven; Lars-Göran Nilsson
Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults.
The journals of gerontology. Series B, Psychological sciences and social sciences 2007;62(2):P112-8.
2006: Johanna Lind; Martin Ingvar; Jonas Persson; Kristel Sleegers; Christine Van Broeckhoven; Rolf Adolfsson; Lars-Göran Nilsson; Lars Nyberg
Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers.
Neuroreport 2006;17(16):1683-6.
2006: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Veerle Bogaerts; Sally Serneels; Kenan Kamali; Ellen Corsmit; Evelyn De Leenheir; Jean-Jacques Martin; Peter Paul De Deyn; Christine Van Broeckhoven; Jessie Theuns
Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):2984-91.
2006: Kristel Sleegers; Nathalie Brouwers; Ilse Gijselinck; Jessie Theuns; Dirk Goossens; Jan Wauters; Jurgen Del-Favero; Marc Cruts; C.M. Duijn; Christine Van Broeckhoven
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.
Brain : a journal of neurology 2006;129(Pt 11):2977-83.
2006: Ann Van Den Bogaert; Kristel Sleegers; Sonia De Zutter; Lien Heyrman; Karl-Fredrik Norrback; Rolf Adolfsson; Christine Van Broeckhoven; Jurgen Del-Favero
Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.
Archives of general psychiatry 2006;63(10):1103-10.
2006: Ann Van Den Bogaert; Kristel Sleegers; Sonia De Zutter; Lien Heyrman; Karl-Fredrik Norrback; Rolf Adolfsson; Christine Van Broeckhoven; Jurgen Del-Favero
No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.
Psychiatric genetics 2006;16(5):209-12.
2006: Jessie Theuns; Nathalie Brouwers; Sebastiaan Engelborghs; Kristel Sleegers; Veerle Bogaerts; Ellen Corsmit; Tim De Pooter; C.M. Duijn; Peter Paul De Deyn; Christine Van Broeckhoven
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
American journal of human genetics 2006;78(6):936-46.
2006: Johanna Lind; Anne Larsson; Jonas Persson; Martin Ingvar; Lars-Göran Nilsson; Lars Bäckman; Rolf Adolfsson; Marc Cruts; Kristel Sleegers; Christine Van Broeckhoven; Lars Nyberg
Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory.
Neuroscience letters 2006;396(1):23-7.
2006: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Veerle Bogaerts; C.M. Duijn; Peter Paul De Deyn; Christine Van Broeckhoven; Bart Dermaut
The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.
Neuroscience letters 2006;392(1-2):72-4.
2005: Rosa Rademakers; Stacey Melquist; Marc Cruts; Jessie Theuns; Jurgen Del-Favero; Parvoneh Poorkaj-Navas; Matt Baker; Kristel Sleegers; Richard Crook; Tim De Pooter; Samira Bel Kacem; Jennifer Adamson; Dirk Van den Bossche; Marleen Van den Broeck; Jennifer Gass; Ellen Corsmit; Peter De Rijk; Natalie Thomas; Sebastiaan Engelborghs; Michael G Heckman; Irene Litvan; Julia Crook; Peter Paul De Deyn; dennis dickson; Gerard D Schellenberg; Christine Van Broeckhoven; Michael Hutton
High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.
Human molecular genetics 2005;14(21):3281-92.
2005: Rosa Rademakers; Marc Cruts; Kristel Sleegers; Bart Dermaut; Jessie Theuns; Yurii Aulchenko; Stefan Weckx; Tim De Pooter; Marleen Van den Broeck; Ellen Corsmit; Peter De Rijk; Jurgen Del-Favero; John C van Swieten; C.M. Duijn; Christine Van Broeckhoven
Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.
American journal of human genetics 2005;77(4):643-52.
2005: Donald J Lehmann; Mario Cortina Borja; Donald R Warden; A David Smith; Kristel Sleegers; Jonathan A Prince; C.M. Duijn; Pat Kehoe
Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease.
American journal of epidemiology 2005;162(4):305-17.
2005: Kristel Sleegers; Tom Den Heijer; Ewoud J van Dijk; Albert Hofman; Aida M Bertoli Avella; Peter J Koudstaal; Monique Breteler; C.M. Duijn
ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.
Neurobiology of aging 2005;26(8):1153-9.
2005: Rosa Rademakers; Kristel Sleegers; Jessie Theuns; Marleen Van den Broeck; Samira Bel Kacem; Lars-Göran Nilsson; Rolf Adolfsson; C.M. Duijn; Christine Van Broeckhoven; Marc Cruts
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.
Neurobiology of aging 2005;26(8):1145-51.
2004: Alejandro Arias Vásquez; Kristel Sleegers; Marieke C J Dekker; Willem A van Gool; John C van Swieten; Yurii Aulchenko; Ben A Oostra; C.M. Duijn
A deletion in DJ-1 and the risk of dementia--a population-based survey.
Neuroscience letters 2004;372(3):196-9.
2004: Esther A Croes; Jessie Theuns; Jeanine J Houwing-Duistermaat; Bart Dermaut; Kristel Sleegers; Gerwin Roks; Marleen Van den Broeck; B van Harten; John C van Swieten; Marc Cruts; Christine Van Broeckhoven; C.M. Duijn
Octapeptide repeat insertions in the prion protein gene and early onset dementia.
Journal of neurology, neurosurgery, and psychiatry 2004;75(8):1166-70.
2004: Kristel Sleegers; Gerwin Roks; Jessie Theuns; Yurii Aulchenko; Rosa Rademakers; Marc Cruts; Willem A van Gool; Christine Van Broeckhoven; Peter Heutink; Ben A Oostra; John C van Swieten; C.M. Duijn
Familial clustering and genetic risk for dementia in a genetically isolated Dutch population.
Brain : a journal of neurology 2004;127(Pt 7):1641-9.
2004: Rosa Rademakers; Marleen Van den Broeck; Kristel Sleegers; C.M. Duijn; Christine Van Broeckhoven; Marc Cruts
Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family.
Neurogenetics 2004;5(1):79-80.
2002: Bart Dermaut; Jessie Theuns; Kristel Sleegers; Hiroshi Hasegawa; Marleen Van den Broeck; Krist'l Vennekens; Ellen Corsmit; Peter St George-Hyslop; Marc Cruts; C.M. Duijn; Christine Van Broeckhoven
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.
American journal of human genetics 2002;70(6):1568-74.
2002: Esther A Croes; Tischa J M van der Cammen; Kristel Sleegers; C.M. Duijn
[From gene to disease; presenilins and Alzheimer disease].
Nederlands tijdschrift voor geneeskunde 2002;146(10):494-5; author reply 495.
2002: Rosa Rademakers; Marc Cruts; Bart Dermaut; Kristel Sleegers; S M Rosso; Marleen Van den Broeck; Hubert Backhovens; John C van Swieten; C.M. Duijn; Christine Van Broeckhoven
Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval.
Molecular psychiatry 2002;7(10):1064-74.