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Herman Slegers

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Rats

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Glioma

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Indra Aerts; Jean-Jacques Martin; Peter Paul De Deyn; Chris Van Ginniken; Xaveer Van Ostade; Mark Kockx; Guido Dua; Herman Slegers
The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade.
Indra Aerts; Bert Grobben; Xaveer Van Ostade; Herman Slegers
Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma.
Kristof Van Kolen; Herman Slegers
Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks.

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All Publications

2011: Indra Aerts; Jean-Jacques Martin; Peter Paul De Deyn; Chris Van Ginniken; Xaveer Van Ostade; Mark Kockx; Guido Dua; Herman Slegers
The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade.
Clinical neurology and neurosurgery 2011;113(3):224-9.
2011: Indra Aerts; Bert Grobben; Xaveer Van Ostade; Herman Slegers
Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma.
European journal of pharmacology 2011;654(1):1-9.
2006: Kristof Van Kolen; Herman Slegers
Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks.
Purinergic signalling 2006;2(3):451-69.
2006: Kristof Van Kolen; Kambiz Gilany; Luc Moens; Eddy L Esmans; Herman Slegers
P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1.
Cellular signalling 2006;18(8):1169-81.
2006: Kristof Van Kolen; Herman Slegers
Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells.
The FEBS journal 2006;273(8):1843-54.
2006: Robin Tuytten; filip Lemiere; Erwin Witters; Walter Van Dongen; Herman Slegers; Russell P Newton; Harry Van Onckelen; Eddy L Esmans
Stainless steel electrospray probe: a dead end for phosphorylated organic compounds?
Journal of chromatography. A 2006;1104(1-2):209-21.
2004: Robin Tuytten; filip Lemiere; Walter Van Dongen; Herman Slegers; Russell P Newton; Eddy L Esmans
Investigation of the use of immobilised metal affinity chromatography for the on-line sample clean up and pre-concentration of nucleotides prior to their determination by ion pair liquid chromatography-electrospray mass spectrometry: a pilot study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;809(2):189-98.
2004: Patrik Claes; Kristof Van Kolen; Dirk Roymans; Daniel Blero; Kris Vissenberg; Christophe Erneux; Jean-Pierre Verbelen; Eddy L Esmans; Herman Slegers
Reactive blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of phosphatidylinositol 3-kinase.
Biochemical pharmacology 2004;67(8):1489-98.
2004: Kristof Van Kolen; Herman Slegers
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
Journal of neurochemistry 2004;89(2):442-53.
2003: Guy L J Vermeiren; Roel Willems; Marc J Claeys; Christiaan Vrints; Herman Slegers; Philippe G Jorens
Influence of ionic and non-ionic radiographic contrast media on leukocyte adhesion molecules.
Mediators of inflammation 2003;12(5):269-75.
2003: K Van Gestel; Herman Slegers; Matthias von Witsch; Jozef Samaj; Frantisek Baluska; Jean-Pierre Verbelen
Immunological evidence for the presence of plant homologues of the actin- related protein Arp3 in tobacco and maize: subcellular localization to actin-enriched pit fields and emerging root hairs.
Protoplasma 2003;222(1-2):45-52.
2003: James W Goding; Bert Grobben; Herman Slegers
Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family.
Biochimica et biophysica acta 2003;1638(1):1-19.
2002: Bert Grobben; Peter Paul De Deyn; Herman Slegers
Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion.
Cell and tissue research 2002;310(3):257-70.
2002: I Banakh; Adnan Sali; V Dubljevic; Bert Grobben; Herman Slegers; James W Goding
Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2002;29(4):307-13.
2002: Roel Willems; Herman Slegers; Inez E Rodrigus; Adriaan C Moulijn; Marc Lenjou; Griet Nijs; Zwi N Berneman; Dirk R Van Bockstaele
Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation.
Experimental hematology 2002;30(7):640-8.
2002: Dirk Roymans; Roel Willems; D R Van Blockstaele; Herman Slegers
Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis.
Clinical & experimental metastasis 2002;19(6):465-76.
2002: Robin Tuytten; filip Lemiere; W Van Dongen; Eddy L Esmans; Herman Slegers
Short capillary ion-pair high-performance liquid chromatography coupled to electrospray (tandem) mass spectrometry for the simultaneous analysis of nucleoside mono-, di- and triphosphates.
Rapid communications in mass spectrometry : RCM 2002;16(12):1205-15.
2001: Kris Laukens; Luc Roef; Erwin Witters; Herman Slegers; Harry Van Onckelen
Cyclic AMP affinity purification and ESI-QTOF MS-MS identification of cytosolic glyceraldehyde 3-phosphate dehydrogenase and two nucleoside diphosphate kinase isoforms from tobacco BY-2 cells.
FEBS letters 2001;508(1):75-9.
2001: L Geerts; Philippe G Jorens; J Willems; M De Ley; Herman Slegers
Natural inhibitors of neutrophil function in acute respiratory distress syndrome.
Critical care medicine 2001;29(10):1920-4.
2001: Bert Grobben; Patrik Claes; Kristof Van Kolen; Dirk Roymans; Paul Fransen; Stanislas U Sys; Herman Slegers
Agonists of the P2Y(AC)-receptor activate MAP kinase by a ras-independent pathway in rat C6 glioma.
Journal of neurochemistry 2001;78(6):1325-38.
2001: Patrik Claes; Bert Grobben; Kristof Van Kolen; Dirk Roymans; Herman Slegers
P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase.
British journal of pharmacology 2001;134(2):402-8.
2001: Dirk Roymans; Herman Slegers
Phosphatidylinositol 3-kinases in tumor progression.
European journal of biochemistry / FEBS 2001;268(3):487-98.
2001: Dirk Roymans; Kris Vissenberg; Chris De Jonghe; Roel Willems; G Engler; N Kimura; Bert Grobben; Patrik Claes; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers
Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome.
Experimental cell research 2001;262(2):145-53.
2001: Dirk Roymans; Bert Grobben; Patrik Claes; Herman Slegers
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Cell biology international 2001;25(5):467-74.
2001: Roel Willems; Els Henckaerts; Marc Lenjou; Griet Nijs; Inez E Rodrigus; Adriaan C Moulijn; Herman Slegers; Zwi N Berneman; Dirk R Van Bockstaele
Establishment of serum-free pre-colony forming unit assays for differentiation of primitive hematopoietic progenitors: serum induces early macrophage differentiation and inhibits early erythroid differentiation of CD34++CD38- cells.
Annals of hematology 2001;80(1):17-25.
2001: Dirk Roymans; Kris Vissenberg; Chris De Jonghe; Bert Grobben; Patrik Claes; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers
Phosphatidylinositol 3-kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP-dependent induction of differentiation in rat C6 glioma.
Journal of neurochemistry 2001;76(2):610-8.
2000: Dirk Roymans; Roel Willems; Kris Vissenberg; Chris De Jonghe; Bert Grobben; Patrik Claes; I Lascu; Dirk R Van Bockstaele; Jean-Pierre Verbelen; Christine Van Broeckhoven; Herman Slegers
Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma.
Experimental cell research 2000;261(1):127-38.
2000: Guy L J Vermeiren; Marc J Claeys; D Van Bockstaele; Bert Grobben; Herman Slegers; Leo Bossaert; Philippe G Jorens
Reperfusion injury after focal myocardial ischaemia: polymorphonuclear leukocyte activation and its clinical implications.
Resuscitation 2000;45(1):35-61.
2000: Bert Grobben; Patrik Claes; Dirk Roymans; Eddy L Esmans; Harry Van Onckelen; Herman Slegers
Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonists.
British journal of pharmacology 2000;130(1):139-45.
2000: Q Wang; Y Wu; T Aerts; Herman Slegers; J Clauwaert
Purification of rat C6 glioma plasma membranes by affinity partitioning.
Biological signals and receptors 2000;9(1):45-52.
1999: Q Wang; Herman Slegers; J Clauwaert
Isolation of plasma membranes from rat C6 glioma cells cultivated on microcarriers.
Acta histochemica 1999;101(3):327-39.
1999: Bert Grobben; K Anciaux; Dirk Roymans; C Stefan; M Bollen; Eddy L Esmans; Herman Slegers
An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma.
Journal of neurochemistry 1999;72(2):826-34.
1998: Roel Willems; Dirk R Van Bockstaele; Filip Lardon; Marc Lenjou; Griet Nijs; Hans-Willem Snoeck; Zwi N Berneman; Herman Slegers
Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation.
The Journal of biological chemistry 1998;273(22):13663-8.
1998: B Loenders; E Van Mechelen; S Nicolaï; N Buyssens; N Van Osselaer; Philippe G Jorens; J Willems; Arnold G Herman; Herman Slegers
Localization of extracellular superoxide dismutase in rat lung: neutrophils and macrophages as carriers of the enzyme.
Free radical biology & medicine 1998;24(7-8):1097-106.
1998: Q Wang; Y Wu; T Aerts; Herman Slegers; J Clauwaert
Expression of IGF-I and IGF-II receptors in rat C6 glioma cells as a function of the growth phase.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1998;8(6):304-13.
1997: K Anciaux; K Van Dommelen; S Nicolai; E Van Mechelen; Herman Slegers
Cyclic AMP-mediated induction of the glial fibrillary acidic protein is independent of protein kinase A activation in rat C6 glioma.
Journal of neuroscience research 1997;48(4):324-33.
1997: K Anciaux; K Van Dommelen; Roel Willems; Dirk Roymans; Herman Slegers
Inhibition of nucleoside diphosphate kinase (NDPK/nm23) by cAMP analogues.
FEBS letters 1997;400(1):75-9.
1996: S Nicolaï; J Willems; A Zwijsen; E Van Mechelen; Herman Slegers
Cyclic AMP-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat C6 glioma.
Free radical biology & medicine 1996;21(4):481-6.
1995: J Willems; W Noppe; Herman Slegers
Reduction of extracellular superoxide dismutase activity by decapeptide derived from FGF-receptor.
Cell biology international 1995;19(11):935-7.
1995: J Willems; Erik Bruyneel; Veerle Noë; Herman Slegers; A Zwijsen; R M Mège; Marc Mareel
Cadherin-dependent cell aggregation is affected by decapeptide derived from rat extracellular super-oxide dismutase.
FEBS letters 1995;363(3):289-92.
1994: S Pype; Herman Slegers; L Moens; W Merlevede; J Goris
Tyrosine phosphorylation of a M(r) 38,000 A/B-type hnRNP protein selectively modulates its RNA binding.
The Journal of biological chemistry 1994;269(50):31457-65.
1994: A Zwijsen; H Blockx; W Van Arnhem; J Willems; L Fransen; K Devos; J Raymackers; A Van de Voorde; Herman Slegers
Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue.
European journal of biochemistry / FEBS 1994;225(3):937-46.
1993: J Willems; A Zwijsen; Herman Slegers; S Nicolaï; J Bettadapura; J Raymackers; T Scarcez
Purification and sequence of rat extracellular superoxide dismutase B secreted by C6 glioma.
The Journal of biological chemistry 1993;268(33):24614-21.
1993: S Pype; Herman Slegers
Inhibition of casein kinase II by dinucleoside polyphosphates.
Enzyme & protein 1993;47(1):14-21.
1990: T Aerts; J Z Xia; Herman Slegers; J de Block; J Clauwaert
Hydrodynamic characterization of the major intrinsic protein from the bovine lens fiber membranes. Extraction in n-octyl-beta-D-glucopyranoside and evidence for a tetrameric structure.
The Journal of biological chemistry 1990;265(15):8675-80.
1987: C Thoen; L Van Hove; Herman Slegers
Purification, subunit structure and properties of a high-molecular-mass protein phosphatase capable of dephosphorylating mRNP of the brine shrimp Artemia sp.
European journal of biochemistry / FEBS 1987;163(3):503-11.
1986: C Thoen; E De Herdt; Herman Slegers
Identification of the ribosomal proteins phosphorylated by the ribosome-associated casein kinase type II from cryptobiotic gastrulae of the brine shrimp Artemia sp.
Biochemical and biophysical research communications 1986;135(2):347-54.
1986: C Thoen; L Van Hove; Herman Slegers
Identification of the substrates of the casein kinase II associated with non-polysomal messenger ribonucleoproteins of A. salina cryptobiotic embryos.
Molecular biology reports 1986;11(2):69-75.
1985: L Van Hove; C Thoen; P Cohen; Herman Slegers
Dephosphorylation of cytoplasmic non-polysomal messenger ribonucleoproteins from cryptobiotic gastrulae of Artemia salina.
Biochemical and biophysical research communications 1985;131(3):1241-50.
1985: E de Herdt; E Piot; A Wahba; Herman Slegers
Initiation factor eIF2 associated with non-polysomal poly(A)-containing messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina.
European journal of biochemistry / FEBS 1985;151(3):455-60.
1985: C Thoen; L Van Hove; P Cohen; Herman Slegers
Identification of protein phosphatases dephosphorylating mRNP proteins from cryptobiotic gastrulae of the brine shrimp A. salina.
Biochemical and biophysical research communications 1985;131(1):84-90.
1985: C Thoen; Herman Slegers
Ribosome-associated cyclic nucleotide-independent protein kinase of Artemia salina cryptobiotic gastrulae.
Biochimica et biophysica acta 1985;825(3):268-79.
1985: E Roggen; Herman Slegers
Isolation and characterization of cytoplasmic poly(A) polymerase from cryptobiotic gastrulae of Artemia salina.
European journal of biochemistry / FEBS 1985;147(2):225-32.
1984: E De Herdt; C Thoen; L Van Hove; E Roggen; E Piot; Herman Slegers
Identification and properties of the 38 000-Mr poly(A)-binding protein of non-polysomal messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina.
European journal of biochemistry / FEBS 1984;139(1):155-62.
1983: E De Herdt; G Marbaix; R Tencer; Herman Slegers
Subcellular distribution in Xenopus laevis oocytes of a microinjected poly(A)-binding protein from Artemia salina gastrulae.
European journal of biochemistry / FEBS 1983;132(3):623-7.
1982: E De Herdt; E Piot; M Kondo; Herman Slegers
The 38,000-Mr poly(A)-binding protein of non-polysomal messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina.
European journal of biochemistry / FEBS 1982;122(3):453-60.
1981: E De Herdt; M Kondo; Herman Slegers
The use of Taka-diastase in a[3H]poly(A) hybridization assay of oligo(U) sequences in RNA.
Journal of biochemical and biophysical methods 1981;5(1):51-5.
1981: Herman Slegers; E De Herdt; M Kondo
Non-polysomal poly(A)-containing messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina.
European journal of biochemistry / FEBS 1981;117(1):111-20.
1981: E De Herdt; F De Voeght; J Clauwaert; M Kondo; Herman Slegers
A cryptobiosis-specific 19S protein complex of Artemia salina gastrulae.
The Biochemical journal 1981;194(1):9-17.
1980: P De Meyer; E De Herdt; M Kondo; Herman Slegers
Affinity chromatography of poly(adenylic acid)-containing ribonucleoproteins on oligothymidylic acid-cellulose.
Journal of biochemical and biophysical methods 1980;2(5):311-4.