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Vladlen Slepak

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Evangelos Liapis; Dario Motti; Simone Sandiford; Gabriel Gaidosh; Konstantin Levay; Qiang Wang; Vladlen Z Slepak
Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.
Benjamin Mason; Margaret W Miller; Michael Schmale; Valery I Shestopalov; Patrick Gibbs; Konstantin Levay; Qiang Wang; Vladlen Z Slepak
Evidence for multiple phototransduction pathways in a reef-building coral.
Galina Dvoriantchikova; Alexander Grinberg; Dmitry Ivanov; Vladlen Z Slepak; Rong Wen; David Barakat; Valery I Shestopalov
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.

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All Publications

2012: Evangelos Liapis; Dario Motti; Simone Sandiford; Gabriel Gaidosh; Konstantin Levay; Qiang Wang; Vladlen Z Slepak
Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.
Journal of neurochemistry 2012;122(3):568-81.
2012: Benjamin Mason; Margaret W Miller; Michael Schmale; Valery I Shestopalov; Patrick Gibbs; Konstantin Levay; Qiang Wang; Vladlen Z Slepak
Evidence for multiple phototransduction pathways in a reef-building coral.
PloS one 2012;7(12):e50371.
2012: Galina Dvoriantchikova; Alexander Grinberg; Dmitry Ivanov; Vladlen Z Slepak; Rong Wen; David Barakat; Valery I Shestopalov
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.
PloS one 2012;7(2):e31991.
2011: Qiang Wang; Cintia B Ueta; Karen L Anderson; Suzy Bianco; Tatyana Chanturiya; Galina Dvoriantchikova; Oksana Gavrilova; Eugenia V Gurevich; Konstantin Levay; R. Damaris Molano; Antonello Pileggi; Vladlen Z Slepak
Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(11):3949-57.
2011: Qunfeng Dong; Xiang Gao; Aaron Garoutte; Alfonso Iovieno; Darlene Miller; Kashi V Revanna; Dionysios A Antonopoulos; Brandon Bates; Jennifer M Brulc; Vladlen Z Slepak; Valery I Shestopalov
Diversity of bacteria at healthy human conjunctiva.
Investigative ophthalmology & visual science 2011;52(8):5408-13.
2010: Simone L Sandiford; Qiang Wang; Konstantin Levay; Peter Buchwald; Vladlen Z Slepak
Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.
Biochemistry 2010;49(24):4998-5006.
2010: Konstantin Levay; Vladlen Z Slepak
Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage.
Experimental cell research 2010;316(7):1254-62.
2009: Simone L Sandiford; Vladlen Z Slepak
The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.
Biochemistry 2009;48(10):2282-9.
2009: Derek H Rosenzweig; K Saidas Nair; Konstantin Levay; Igor V Peshenko; John W Crabb; Alexander M Dizhoor; Vladlen Z Slepak
Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization.
The Biochemical journal 2009;417(3):803-12.
2009: Vladlen Z Slepak
Structure, function, and localization of Gβ5-RGS complexes.
Progress in molecular biology and translational science 2009;86():157-203.
2008: D Grabowska; Muralidharan Jayaraman; Kevin M Kaltenbronn; S L Sandiford; Q Wang; S Jenkins; Vladlen Z Slepak; Yoland Smith; Kendall J Blumer
Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain.
Neuroscience 2008;151(4):969-82.
2008: Vladlen Z Slepak; James B Hurley
Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: interaction-restricted diffusion.
IUBMB life 2008;60(1):2-9.
2007: Konstantin Levay; Vladlen Z Slepak
Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression.
The Journal of clinical investigation 2007;117(9):2672-83.
2007: Tatiana Slepak; Manshu Tang; Vladlen Z Slepak; Kent Lai
Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.
Molecular genetics and metabolism 2007;92(1-2):78-87.
2007: Vijaya Narayanan; Simone L Sandiford; Qiang Wang; Tal Keren-Raifman; Konstantin Levay; Vladlen Z Slepak
Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit.
Biochemistry 2007;46(23):6859-70.
2007: Derek H Rosenzweig; K Saidas Nair; Junhua Wei; Qiang Wang; Gregory G Garwin; John C Saari; Ching-Kang Chen; Alan V Smrcka; Anand Swaroop; Janis Lem; James B Hurley; Vladlen Z Slepak
Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(20):5484-94.
2007: Susan M Hanson; Whitney M Cleghorn; Derek J Francis; Sergey A Vishnivetskiy; Dayanidhi Raman; Xiufeng Song; K Saidas Nair; Vladlen Z Slepak; Candice S Klug; Vsevolod V Gurevich
Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.
Journal of molecular biology 2007;368(2):375-87.
2006: James B Ames; Konstantin Levay; Jennifer Wingard; Jacqueline D Lusin; Vladlen Z Slepak
Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin.
The Journal of biological chemistry 2006;281(48):37237-45.
2005: K Saidas Nair; Susan M Hanson; Ana Mendez; Eugenia V Gurevich; Matthew J Kennedy; Valery I Shestopalov; Sergey A Vishnivetskiy; Jeannie Chen; James B Hurley; Vsevolod V Gurevich; Vladlen Z Slepak
Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.
Neuron 2005;46(4):555-67.
2005: K Saidas Nair; Ana Mendez; Joe B Blumer; Derek H Rosenzweig; Vladlen Z Slepak
The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors.
Investigative ophthalmology & visual science 2005;46(1):383-9.
2004: K Saidas Nair; Susan M Hanson; Matthew J Kennedy; James B Hurley; Vsevolod V Gurevich; Vladlen Z Slepak
Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors.
The Journal of biological chemistry 2004;279(39):41240-8.
2004: D Scott Witherow; Vladlen Z Slepak
Biochemical purification and functional analysis of complexes between the G-protein subunit Gbeta5 and RGS proteins.
Methods in enzymology 2004;390():149-62.
2003: Christina Gutierrez-Ford; Konstantin Levay; Aldrin Gomes; Erasmo M Perera; Tapan Som; you-me kim; Jeffrey L Benovic; Gary D Berkovitz; Vladlen Z Slepak
Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin.
Biochemistry 2003;42(49):14553-65.
2003: Nagaraj Balasubramanian; Vladlen Z Slepak
Light-mediated activation of Rac-1 in photoreceptor outer segments.
Current biology : CB 2003;13(15):1306-10.
2003: D Scott Witherow; Stephen C Tovey; Qiang Wang; Gary B Willars; Vladlen Z Slepak
G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction.
The Journal of biological chemistry 2003;278(23):21307-13.
2003: Ida Rishal; Tal Keren-Raifman; Daniel Yakubovich; Tatiana Ivanina; Carmen W Dessauer; Vladlen Z Slepak; Nathan Dascal
Na+ promotes the dissociation between Galpha GDP and Gbeta gamma, activating G protein-gated K+ channels.
The Journal of biological chemistry 2003;278(6):3840-5.
2003: D Scott Witherow; Vladlen Z Slepak
A novel kind of G protein heterodimer: the G beta5-RGS complex.
Receptors & channels 2003;9(3):205-12.
2002: K Saidas Nair; Nagaraj Balasubramanian; Vladlen Z Slepak
Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors.
Current biology : CB 2002;12(5):421-5.
2001: Nagaraj Balasubramanian; Konstantin Levay; Tal Keren-Raifman; E Faurobert; Vladlen Z Slepak
Phosphorylation of the regulator of G protein signaling RGS9-1 by protein kinase A is a potential mechanism of light- and Ca2+-mediated regulation of G protein function in photoreceptors.
Biochemistry 2001;40(42):12619-27.
2001: Tal Keren-Raifman; AK Bera; D Zveig; Sagit Peleg; D Scott Witherow; Vladlen Z Slepak; Nathan Dascal
Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5.
FEBS letters 2001;492(1-2):20-8.
2000: D Scott Witherow; Qiang Wang; Konstantin Levay; JL Cabrera; Jeannie Chen; Gary B Willars; Vladlen Z Slepak
Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells.
The Journal of biological chemistry 2000;275(32):24872-80.
2000: DK Satpaev; Vladlen Z Slepak
Analysis of protein-protein interactions in phototransduction cascade using surface plasmon resonance.
Methods in enzymology 2000;316():20-40.
2000: Vladlen Z Slepak
Application of surface plasmon resonance for analysis of protein-protein interactions in the G protein-mediated signal transduction pathway.
Journal of molecular recognition : JMR 2000;13(1):20-6.
1999: Konstantin Levay; JL Cabrera; DK Satpaev; Vladlen Z Slepak
Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2503-7.
1998: Cheryl M Craft; J Xu; Vladlen Z Slepak; X Zhan-Poe; Xuemei Zhu; Bruce Brown; R N Lolley
PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins.
Biochemistry 1998;37(45):15758-72.
1998: Konstantin Levay; DK Satpaev; Alexey N Pronin; Jeffrey L Benovic; Vladlen Z Slepak
Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases.
Biochemistry 1998;37(39):13650-9.
1998: JL Cabrera; F de Freitas; DK Satpaev; Vladlen Z Slepak
Identification of the Gbeta5-RGS7 protein complex in the retina.
Biochemical and biophysical research communications 1998;249(3):898-902.
1998: DK Satpaev; Ching-Kang Chen; A Scotti; Melvin I Simon; James B Hurley; Vladlen Z Slepak
Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase.
Biochemistry 1998;37(28):10256-62.
1997: Alexey N Pronin; DK Satpaev; Vladlen Z Slepak; Jeffrey L Benovic
Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain.
The Journal of biological chemistry 1997;272(29):18273-80.
1997: B Yu; Vladlen Z Slepak; Melvin I Simon
Characterization of a Goalpha mutant that binds xanthine nucleotides.
The Journal of biological chemistry 1997;272(29):18015-9.
1996: A J Watson; Anna M Aragay; Vladlen Z Slepak; M I Simon
A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina.
The Journal of biological chemistry 1996;271(45):28154-60.
1996: C A Doupnik; C W Dessauer; Vladlen Z Slepak; Alfred G Gilman; Norman Davidson; Henry A Lester
Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits.
Neuropharmacology 1996;35(7):923-31.
1995: Vladlen Z Slepak; Nikolai O Artemyev; Y Zhu; C L Dumke; L Sabacan; John Sondek; Heidi E Hamm; M D Bownds; Vadim Y Arshavsky
An effector site that stimulates G-protein GTPase in photoreceptors.
The Journal of biological chemistry 1995;270(24):14319-24.
1995: J Xu; Dianqing Wu; Vladlen Z Slepak; M I Simon
The N terminus of phosducin is involved in binding of beta gamma subunits of G protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2086-90.
1995: Vladlen Z Slepak; A Katz; M I Simon
Functional analysis of a dominant negative mutant of G alpha i2.
The Journal of biological chemistry 1995;270(8):4037-41.
1993: Vladlen Z Slepak; Michael W Quick; Anna M Aragay; Norman Davidson; Henry A Lester; M I Simon
Random mutagenesis of G protein alpha subunit G(o)alpha. Mutations altering nucleotide binding.
The Journal of biological chemistry 1993;268(29):21889-94.
1993: Vladlen Z Slepak; Thomas Wilkie; M I Simon
Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli.
The Journal of biological chemistry 1993;268(2):1414-23.
1991: Thomas Wilkie; P A Scherle; M P Strathmann; Vladlen Z Slepak; M I Simon
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10049-53.
1991: T T Amatruda; D A Steele; Vladlen Z Slepak; M I Simon
G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5587-91.
1989: Vladlen Z Slepak; A N Pronin; O G Kiselyov; V L Voeikov; E I Frolova; Valery M Lipkin
Structure and function of the alpha-subunit of the GTP-binding protein Go from bovine cerebellum.
Journal of protein chemistry 1989;8(3):436-8.
1989: N B Levina; Vladlen Z Slepak; O G Kiselev; V V Shemiakin; A A Khokhlachev
[Use of electroblotting as a method for preparing samples of proteins and their fragments for microsequencing].
Bioorganicheskaia khimiia 1989;15(1):24-31.
1987: Vladlen Z Slepak; A N Pronin; A B Shlensky; N B Levina; V L Voeikov; Valery M Lipkin
Primary structure of bovine cerebellum GTP-binding protein G39 and its effect on the adenylate cyclase system.
FEBS letters 1987;226(1):91-5.
1987: V L Voeĭkov; A N Pronin; Vladlen Z Slepak; A N Chestukhin; A B Shlenskiĭ
[High molecular weight forms of GTP-binding regulatory proteins from the bovine cerebellum].
Biokhimii͡a (Moscow, Russia) 1987;52(11):1766-9.
1987: Iu A Ovchinnikov; Vladlen Z Slepak; A N Pronin; A B Shlenskiĭ; N B Levina
[G39, a GTP-binding protein from the bovine cerebellum. Amino acid sequence and nucleotide sequence of corresponding cDNA].
Doklady Akademii nauk SSSR 1987;297(4):1006-9.