Joyce Slingerland

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Larrea Michelle D; Wander Seth A; Slingerland Joyce M
p27 as Jekyll and Hyde: regulation of cell cycle and cell motility.
Larrea Michelle D; Hong Feng; Wander Seth A; da Silva Thiago G; Helfman David; Lannigan Deborah; Smith Jeffrey A; Slingerland Joyce M
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Chen Yi; Guggisberg Natalia; Jorda Merce; Gonzalez-Angulo Ana; Hennessy Bryan; Mills Gordon B; Tan Chen-Keat; Slingerland Joyce M
Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors.

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All Publications

2009: Larrea Michelle D; Wander Seth A; Slingerland Joyce M
p27 as Jekyll and Hyde: regulation of cell cycle and cell motility.
Cell cycle (Georgetown, Tex.) 2009;8(21):3455-61.
2009: Larrea Michelle D; Hong Feng; Wander Seth A; da Silva Thiago G; Helfman David; Lannigan Deborah; Smith Jeffrey A; Slingerland Joyce M
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9268-73.
2009: Chen Yi; Guggisberg Natalia; Jorda Merce; Gonzalez-Angulo Ana; Hennessy Bryan; Mills Gordon B; Tan Chen-Keat; Slingerland Joyce M
Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3396-405.
2008: Larrea Michelle D; Liang Jiyong; Da Silva Thiago; Hong Feng; Shao Shan H; Han Kathy; Dumont D; Slingerland Joyce M
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.
Molecular and cellular biology 2008;28(20):6462-72.
2008: Hong Feng; Larrea Michelle D; Doughty Cheryl; Kwiatkowski David J; Squillace Rachel; Slingerland Joyce M
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation.
Molecular cell 2008;30(6):701-11.
2008: Silva Orlando; Lopes Gilberto; Morgenzstern Daniel; Lobo Christopher; Doliny Philomena; Santos Edgardo; Abdullah Sakher; Gautam Umang; Reis Isildinha; Welsh Catherine; Slingerland Joyce; Hurley Judith; Gluck Stefan
A Phase II trial of split, low-dose docetaxel and low-dose capecitabine: a tolerable and efficacious regimen in the first-line treatment of patients with HER2/neu-negative metastatic breast cancer.
Clinical breast cancer 2008;8(2):162-7.
2008: Chu Isabel M; Hengst Ludger; Slingerland Joyce M
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy.
Nature reviews. Cancer 2008;8(4):253-67.
2007: Sun Jun; Nawaz Zafar; Slingerland Joyce M
Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2651-62.
2007: Chu Isabel; Arnaout Angel; Loiseau Sophie; Sun Jun; Seth Arun; McMahon Chris; Chun Kathy; Hennessy Bryan; Mills Gordon B; Nawaz Zafar; Slingerland Joyce M
Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer.
The Journal of clinical investigation 2007;117(8):2205-15.
2007: Govindarajan Baskaran; Sligh James E; Vincent Bethaney J; Li Meiling; Canter Jeffrey A; Nickoloff Brian J; Rodenburg Richard J; Smeitink Jan A; Oberley Larry; Zhang Yuping; Slingerland Joyce; Arnold Rebecca S; Lambeth J David; Cohen Cynthia; Hilenski Lu; Griendling Kathy; Martínez-Diez Marta; Cuezva José M; Arbiser Jack L
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
The Journal of clinical investigation 2007;117(3):719-29.
2007: Liang Jiyong; Shao Shan H; Xu Zhi-Xiang; Hennessy Bryan; Ding Zhiyong; Larrea Michelle; Kondo Seiji; Dumont Dan J; Gutterman Jordan U; Walker Cheryl L; Slingerland Joyce M; Mills Gordon B
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Nature cell biology 2007;9(2):218-24.
2007: Chu Isabel; Sun Jun; Arnaout Angel; Kahn Harriette; Hanna Wedad; Narod Steven; Sun Ping; Tan Cheng-Keat; Hengst Ludger; Slingerland Joyce
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
Cell 2007;128(2):281-94.
2006: Dhananjayan Sarath C; Ramamoorthy Sivapriya; Khan Obaid Y; Ismail Ayesha; Sun Jun; Slingerland Joyce; O'Malley Bert W; Nawaz Zafar
WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2343-54.
2005: Sandhu Charanjit; Connor Michael; Kislinger Thomas; Slingerland Joyce; Emili Andrew
Global protein shotgun expression profiling of proliferating mcf-7 breast cancer cells.
Journal of proteome research 2005;4(3):674-89.
2005: Sheng Wang; Wang Guizhi; Wang Yelina; Liang Jiyong; Wen Jianping; Zheng Peng-Sheng; Wu Yaojiong; Lee Vivian; Slingerland Joyce; Dumont Dan; Yang Burton B
The roles of versican V1 and V2 isoforms in cell proliferation and apoptosis.
Molecular biology of the cell 2005;16(3):1330-40.
2005: Chu Isabel; Blackwell Kimberly; Chen Susie; Slingerland Joyce
The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer.
Cancer research 2005;65(1):18-25.
2005: Esserman Laura J; Ozanne Elissa M; Dowsett Mitch; Slingerland Joyce M
Tamoxifen may prevent both ER+ and ER- breast cancers and select for ER- carcinogenesis: an alternative hypothesis.
Breast cancer research : BCR 2005;7(6):R1153-8.
2004: Alkarain A; Jordan R; Slingerland J
p27 deregulation in breast cancer: prognostic significance and implications for therapy.
Journal of mammary gland biology and neoplasia 2004;9(1):67-80.
2004: Alkarain Angel; Slingerland Joyce
Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer.
Breast cancer research : BCR 2004;6(1):13-21.
2003: Liang Jiyong; Slingerland Joyce M
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.
Cell cycle (Georgetown, Tex.) 2003;2(4):339-45.
2003: Connor Michael K; Kotchetkov Rouslan; Cariou Sandrine; Resch Ansgar; Lupetti Rafaella; Beniston Richard G; Melchior Frauke; Hengst Ludger; Slingerland Joyce M
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.
Molecular biology of the cell 2003;14(1):201-13.
2002: Donovan Jeffrey C H; Rothenstein Jeffrey M; Slingerland Joyce M
Non-malignant and tumor-derived cells differ in their requirement for p27Kip1 in transforming growth factor-beta-mediated G1 arrest.
The Journal of biological chemistry 2002;277(44):41686-92.
2002: Liang Jiyong; Zubovitz Judit; Petrocelli Teresa; Kotchetkov Rouslan; Connor Michael K; Han Kathy; Lee Jin-Hwa; Ciarallo Sandra; Catzavelos Charles; Beniston Richard; Franssen Edmee; Slingerland Joyce M
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest.
Nature medicine 2002;8(10):1153-60.
2002: Ciarallo Sandra; Subramaniam Venkateswaran; Hung Wesley; Lee Jin-Hwa; Kotchetkov Rouslan; Sandhu Charanjit; Milic Andrea; Slingerland Joyce M
Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest.
Molecular and cellular biology 2002;22(9):2993-3002.
2001: Donovan J C; Milic A; Slingerland J M
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells.
The Journal of biological chemistry 2001;276(44):40888-95.
2001: Gstaiger M; Jordan R; Lim M; Catzavelos C; Mestan J; Slingerland J; Krek W
Skp2 is oncogenic and overexpressed in human cancers.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5043-8.
2001: Petrocelli T; Slingerland J M
PTEN deficiency: a role in mammary carcinogenesis.
Breast cancer research : BCR 2001;3(6):356-60.
2000: Chappuis P O; Kapusta L; Bégin L R; Wong N; Brunet J S; Narod S A; Slingerland J; Foulkes W D
Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(24):4045-52.
2000: Sandhu C; Donovan J; Bhattacharya N; Stampfer M; Worland P; Slingerland J
Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells.
Oncogene 2000;19(47):5314-23.
2000: Petrocelli T; Slingerland J
UVB induced cell cycle checkpoints in an early stage human melanoma line, WM35.
Oncogene 2000;19(39):4480-90.
2000: Cariou S; Donovan J C; Flanagan W M; Milic A; Bhattacharya N; Slingerland J M
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9042-6.
2000: Tamir A; Petrocelli T; Stetler K; Chu W; Howard J; Croix B S; Slingerland J; Ben-David Y
Stem cell factor inhibits erythroid differentiation by modulating the activity of G1-cyclin-dependent kinase complexes: a role for p27 in erythroid differentiation coupled G1 arrest.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(5):269-77.
2000: Sandhu C; Peehl D M; Slingerland J
p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells.
Cancer research 2000;60(10):2616-22.
2000: Slingerland J; Pagano M
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
Journal of cellular physiology 2000;183(1):10-7.
2000: Tsihlias J; Zhang W; Bhattacharya N; Flanagan M; Klotz L; Slingerland J
Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells.
Oncogene 2000;19(5):670-9.
2000: Donovan J; Slingerland J
Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer.
Breast cancer research : BCR 2000;2(2):116-24.
2000: Slingerland J
Transforming growth factor-beta and breast cancer: Introduction.
Breast cancer research : BCR 2000;2(2):91.
2000: Sandhu C; Slingerland J
Deregulation of the cell cycle in cancer.
Cancer detection and prevention 2000;24(2):107-18.
1999: Catzavelos C; Tsao M S; DeBoer G; Bhattacharya N; Shepherd F A; Slingerland J M
Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras.
Cancer research 1999;59(3):684-8.
1999: Flørenes V A; Lu C; Bhattacharya N; Rak J; Sheehan C; Slingerland J M; Kerbel R S
Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma.
Oncogene 1999;18(4):1023-32.
1999: Tsihlias J; Kapusta L; Slingerland J
The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer.
Annual review of medicine 1999;50():401-23.
1998: Lauper N; Beck A R; Cariou S; Richman L; Hofmann K; Reith W; Slingerland J M; Amati B
Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle.
Oncogene 1998;17(20):2637-43.
1998: St Croix B; Sheehan C; Rak J W; Flørenes V A; Slingerland J M; Kerbel R S
E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1).
The Journal of cell biology 1998;142(2):557-71.
1998: Flørenes V A; Maelandsmo G M; Kerbel R S; Slingerland J M; Nesland J M; Holm R
Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival.
The American journal of pathology 1998;153(1):305-12.
1998: Zhang W; Kapusta L R; Slingerland J M; Klotz L H
Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia, and benign prostatic epithelium.
Cancer research 1998;58(4):619-21.
1998: Jordan R C; Bradley G; Slingerland J
Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity.
The American journal of pathology 1998;152(2):585-90.
1998: Tsihlias J; Kapusta L R; DeBoer G; Morava-Protzner I; Zbieranowski I; Bhattacharya N; Catzavelos G C; Klotz L H; Slingerland J M
Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma.
Cancer research 1998;58(3):542-8.
1998: Cariou S; Catzavelos C; Slingerland J M
Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1.
Breast cancer research and treatment 1998;52(1-3):29-41.
1997: Radeva G; Petrocelli T; Behrend E; Leung-Hagesteijn C; Filmus J; Slingerland J; Dedhar S
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression.
The Journal of biological chemistry 1997;272(21):13937-44.
1997: Sandhu C; Garbe J; Bhattacharya N; Daksis J; Pan C H; Yaswen P; Koh J; Slingerland J M; Stampfer M R
Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells.
Molecular and cellular biology 1997;17(5):2458-67.
1997: LaBaer J; Garrett M D; Stevenson L F; Slingerland J M; Sandhu C; Chou H S; Fattaey A; Harlow E
New functional activities for the p21 family of CDK inhibitors.
Genes & development 1997;11(7):847-62.
1997: Catzavelos C; Bhattacharya N; Ung Y C; Wilson J A; Roncari L; Sandhu C; Shaw P; Yeger H; Morava-Protzner I; Kapusta L; Franssen E; Pritchard K I; Slingerland J M
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer.
Nature medicine 1997;3(2):227-30.
1996: Flørenes V A; Bhattacharya N; Bani M R; Ben-David Y; Kerbel R S; Slingerland J M
TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip1.
Oncogene 1996;13(11):2447-57.
1996: St Croix B; Flørenes V A; Rak J W; Flanagan M; Bhattacharya N; Slingerland J M; Kerbel R S
Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents.
Nature medicine 1996;2(11):1204-10.
1996: Petrocelli T; Poon R; Drucker D J; Slingerland J M; Rosen C F
UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints.
Oncogene 1996;12(7):1387-96.
1995: Liu L; Lassam N J; Slingerland J M; Bailey D; Cole D; Jenkins R; Hogg D
Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.
Oncogene 1995;11(2):405-12.
1994: Hengst L; Dulic V; Slingerland J M; Lees E; Reed S I
A cell cycle-regulated inhibitor of cyclin-dependent kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5291-5.
1994: Slingerland J M; Hengst L; Pan C H; Alexander D; Stampfer M R; Reed S I
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.
Molecular and cellular biology 1994;14(6):3683-94.
1994: Lishner M; Slingerland J; Theresa C; Sutcliffe S B
The response of diffuse large cell and other intermediate grade non-Hodgkin's lymphomas to adriamycin containing combination chemotherapy.
Leukemia & lymphoma 1994;13(1-2):131-6.
1994: Reed S I; Bailly E; Dulic V; Hengst L; Resnitzky D; Slingerland J
G1 control in mammalian cells.
Journal of cell science. Supplement 1994;18():69-73.
1993: Slingerland J M; Jenkins J R; Benchimol S
The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.
The EMBO journal 1993;12(3):1029-37.
1991: Slingerland J M; Benchimol S
Transforming activity of mutant human p53 alleles.
Journal of cellular physiology 1991;148(3):391-5.
1991: Lishner M; Slingerland J; Barr J; Panzarella T; Degendorfer P; Sutcliffe S
Second malignant neoplasms in patients with non Hodgkin's lymphoma.
Hematological oncology 1991;9(3):169-79.
1991: Slingerland J M; Minden M D; Benchimol S
Mutation of the p53 gene in human acute myelogenous leukemia.
Blood 1991;77(7):1500-7.
1989: Slingerland J M; Grossman R F; Chamberlain D; Tremblay C E
Pulmonary manifestations of tuberous sclerosis in first degree relatives.
Thorax 1989;44(3):212-4.

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