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Christine Slingsby

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Living Beings

Cattle
Rats

Procedures

Anatomy

Crystalline Lens

Physiology

Protein Folding

Phenomena

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Cataract

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Publications

TOP 3
Guido Kappé; Andrew G Purkiss; Siebe T van Genesen; Christine Slingsby; Nicolette H Lubsen
Explosive expansion of betagamma-crystallin genes in the ancestral vertebrate.
C Bagnéris; Orval A Bateman; Claire E Naylor; Nora B Cronin; Wilbert C Boelens; N H Keep; Christine Slingsby
Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.
Paul Evans; Christine Slingsby; Bonnie A Wallace
Association of partially folded lens betaB2-crystallins with the alpha-crystallin molecular chaperone.

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All Publications

2010: Guido Kappé; Andrew G Purkiss; Siebe T van Genesen; Christine Slingsby; Nicolette H Lubsen
Explosive expansion of betagamma-crystallin genes in the ancestral vertebrate.
Journal of molecular evolution 2010;71(3):219-30.
2009: C Bagnéris; Orval A Bateman; Claire E Naylor; Nora B Cronin; Wilbert C Boelens; N H Keep; Christine Slingsby
Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.
Journal of molecular biology 2009;392(5):1242-52.
2008: Paul Evans; Christine Slingsby; Bonnie A Wallace
Association of partially folded lens betaB2-crystallins with the alpha-crystallin molecular chaperone.
The Biochemical journal 2008;409(3):691-9.
2007: Andrew G Purkiss; Orval A Bateman; Keith Wyatt; Phillip A Wilmarth; Larry L David; Graeme Wistow; Christine Slingsby
Biophysical properties of gammaC-crystallin in human and mouse eye lens: the role of molecular dipoles.
Journal of molecular biology 2007;372(1):205-22.
2007: Paul Evans; Orval A Bateman; Christine Slingsby; Bonnie A Wallace
A reference dataset for circular dichroism spectroscopy tailored for the betagamma-crystallin lens proteins.
Experimental eye research 2007;84(5):1001-8.
2007: Myron A Smith; Orval A Bateman; Rainer Jaenicke; Christine Slingsby
Mutation of interfaces in domain-swapped human betaB2-crystallin.
Protein science : a publication of the Protein Society 2007;16(4):615-25.
2006: Keith Wyatt; Helen E White; Luchun Wang; Orval A Bateman; Christine Slingsby; Elena V Orlova; Graeme Wistow
Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens.
Structure (London, England : 1993) 2006;14(12):1823-34.
2006: Laura Marín-Vinader; Carla Onnekink; Siebe T van Genesen; Christine Slingsby; Nicolette H Lubsen
In vivo heteromer formation. Expression of soluble betaA4-crystallin requires coexpression of a heteromeric partner.
The FEBS journal 2006;273(14):3172-82.
2005: Robin Stamler; Guido Kappé; Wilbert C Boelens; Christine Slingsby
Wrapping the alpha-crystallin domain fold in a chaperone assembly.
Journal of molecular biology 2005;353(1):68-79.
2005: Sebastian M Shimeld; Andrew G Purkiss; Ron P H Dirks; Orval A Bateman; Christine Slingsby; Nicolette H Lubsen
Urochordate betagamma-crystallin and the evolutionary origin of the vertebrate eye lens.
Current biology : CB 2005;15(18):1684-9.
2005: Graeme Wistow; Keith Wyatt; Larry L David; Chun Gao; Orval A Bateman; Steven L Bernstein; Stanislav I Tomarev; Lorenzo Segovia; Christine Slingsby; Thomas S Vihtelic
gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates.
The FEBS journal 2005;272(9):2276-91.
2005: James T MacDonald; Andrew G Purkiss; Myron A Smith; Paul Evans; Julia M Goodfellow; Christine Slingsby
Unfolding crystallins: the destabilizing role of a beta-hairpin cysteine in betaB2-crystallin by simulation and experiment.
Protein science : a publication of the Protein Society 2005;14(5):1282-92.
2005: Jianguo Fan; Robert Fariss; Andrew G Purkiss; Christine Slingsby; Aileen Sandilands; Roy Quinlan; Graeme Wistow; Ana B Chepelinsky
Specific interaction between lens MIP/Aquaporin-0 and two members of the gamma-crystallin family.
Molecular vision 2005;11():76-87.
2004: Durga Srikanthan; Orval A Bateman; Andrew G Purkiss; Christine Slingsby
Sulfur in human crystallins.
Experimental eye research 2004;79(6):823-31.
2004: Hans Bloemendal; Wilfried de Jong; Rainer Jaenicke; Nicolette H Lubsen; Christine Slingsby; Annette Tardieu
Ageing and vision: structure, stability and function of lens crystallins.
Progress in biophysics and molecular biology 2004;86(3):407-85.
2004: Paul Evans; Keith Wyatt; Graeme Wistow; Orval A Bateman; Bonnie A Wallace; Christine Slingsby
The P23T cataract mutation causes loss of solubility of folded gammaD-crystallin.
Journal of molecular biology 2004;343(2):435-44.
2004: M Ashwin Reddy; Orval A Bateman; Christina F Chakarova; J Ferris; Vanita Berry; E Lomas; R Sarra; M A Smith; Anthony T Moore; Shomi S Bhattacharya; Christine Slingsby
Characterization of the G91del CRYBA1/3-crystallin protein: a cause of human inherited cataract.
Human molecular genetics 2004;13(9):945-53.
2004: Bonnie A Wallace; Frank Wien; Andrew J Miles; Jonathan G Lees; Soren Vronning Hoffmann; Paul Evans; Graeme Wistow; Christine Slingsby
Biomedical applications of synchrotron radiation circular dichroism spectroscopy: identification of mutant proteins associated with disease and development of a reference database for fold motifs.
Faraday discussions 2004;126():237-43; discussion 245-54.
2004: David A Lee; Sandrine Fefeu; Adrian A Edo-Ukeh; Christine A Orengo; Christine Slingsby
EyeSite: a semi-automated database of protein families in the eye.
Nucleic acids research 2004;32(Database issue):D148-52.
2003: Rob L M van Montfort; Orval A Bateman; Nicolette H Lubsen; Christine Slingsby
Crystal structure of truncated human betaB1-crystallin.
Protein science : a publication of the Protein Society 2003;12(11):2606-12.
2003: Orval A Bateman; R Sarra; Siebe T van Genesen; Guido Kappé; Nicolette H Lubsen; Christine Slingsby
The stability of human acidic beta-crystallin oligomers and hetero-oligomers.
Experimental eye research 2003;77(4):409-22.
2003: J Andrew Aquilina; Justin L P Benesch; Orval A Bateman; Christine Slingsby; Carol V Robinson
Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10611-6.
2003: Ajit Basak; Orval A Bateman; Christine Slingsby; Ajay Pande; Neer Asherie; Olutayo Ogun; George B. Benedek; Jayanti Pande
High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract.
Journal of molecular biology 2003;328(5):1137-47.
2003: Orval A Bateman; Andrew G Purkiss; Rob L M van Montfort; Christine Slingsby; C Graham; Graeme Wistow
Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens.
Biochemistry 2003;42(15):4349-56.
2003: Emeline Nandrot; Christine Slingsby; Ajit Basak; M Cherif-Chefchaouni; Bouchra Benazzouz; Yassir Hajaji; S Boutayeb; Olivier Gribouval; Laurence Arbogast; Amina Berraho; marc Mordekhaï ABITBOL; Latifa Hilal
Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts.
Journal of medical genetics 2003;40(4):262-7.
2002: Andrew G Purkiss; Orval A Bateman; Julia M Goodfellow; Nicolette H Lubsen; Christine Slingsby
The X-ray crystal structure of human gamma S-crystallin C-terminal domain.
The Journal of biological chemistry 2002;277(6):4199-205.
2001: Rob L M van Montfort; Eman Basha; K L Friedrich; Christine Slingsby; Elizabeth Vierling
Crystal structure and assembly of a eukaryotic small heat shock protein.
Nature structural biology 2001;8(12):1025-30.
2001: Orval A Bateman; Nicolette H Lubsen; Christine Slingsby
Association behaviour of human betaB1-crystallin and its truncated forms.
Experimental eye research 2001;73(3):321-31.
2001: Debasish Sinha; M Keith Wyatt; R Sarra; Cynthia Jaworski; Christine Slingsby; Caroline Thaung; Lewis K Pannell; W G Robison; Jack Favor; M Lyon; Graeme Wistow
A temperature-sensitive mutation of Crygs in the murine Opj cataract.
The Journal of biological chemistry 2001;276(12):9308-15.
2001: NJ Clout; M Kretschmar; Rainer Jaenicke; Christine Slingsby
Crystal structure of the calcium-loaded spherulin 3a dimer sheds light on the evolution of the eye lens betagamma-crystallin domain fold.
Structure (London, England : 1993) 2001;9(2):115-24.
2001: Rob L M van Montfort; Christine Slingsby; Elizabeth Vierling
Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones.
Advances in protein chemistry 2001;59():105-56.
2001: Rainer Jaenicke; Christine Slingsby
Lens crystallins and their microbial homologs: structure, stability, and function.
Critical reviews in biochemistry and molecular biology 2001;36(5):435-99.
2000: NJ Clout; Ajit Basak; K Wieligmann; Orval A Bateman; Rainer Jaenicke; Christine Slingsby
The N-terminal domain of betaB2-crystallin resembles the putative ancestral homodimer.
Journal of molecular biology 2000;304(3):253-7.
2000: P Hobby; M Keith Wyatt; W Gan; Steven L Bernstein; Stanislav I Tomarev; Christine Slingsby; Graeme Wistow
Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye.
Molecular vision 2000;6():72-8.
1999: Christine Slingsby; NJ Clout
Structure of the crystallins.
Eye (London, England) 1999;13 ( Pt 3b)():395-402.
1998: S Palme; Rainer Jaenicke; Christine Slingsby
Unusual domain pairing in a mutant of bovine lens gammaB-crystallin.
Journal of molecular biology 1998;279(5):1053-9.
1998: G Wright; Ajit K Basak; K Wieligmann; EM Mayr; Christine Slingsby
Circular permutation of betaB2-crystallin changes the hierarchy of domain assembly.
Protein science : a publication of the Protein Society 1998;7(6):1280-5.
1998: Ajit K Basak; R C Kroone; Nicolette H Lubsen; Claire E Naylor; Rainer Jaenicke; Christine Slingsby
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis.
Protein engineering 1998;11(5):337-44.
1998: Ayçe Atalay; A Ogus; Orval A Bateman; Christine Slingsby
Vitamin C induced oxidation of eye lens gamma crystallins.
Biochimie 1998;80(4):283-8.
1998: S Palme; Rainer Jaenicke; Christine Slingsby
X-ray structures of three interface mutants of gammaB-crystallin from bovine eye lens.
Protein science : a publication of the Protein Society 1998;7(3):611-8.
1997: BV Norledge; R E Hay; Orval A Bateman; Christine Slingsby; H P Driessen
Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD.
Experimental eye research 1997;65(5):609-30.
1997: NJ Clout; Christine Slingsby; Graeme Wistow
Picture story. An eye on crystallins.
Nature structural biology 1997;4(9):685.
1997: BV Norledge; S Trinkl; Rainer Jaenicke; Christine Slingsby
The X-ray structure of a mutant eye lens beta B2-crystallin with truncated sequence extensions.
Protein science : a publication of the Protein Society 1997;6(8):1612-20.
1997: S Palme; Christine Slingsby; Rainer Jaenicke
Mutational analysis of hydrophobic domain interactions in gamma B-crystallin from bovine eye lens.
Protein science : a publication of the Protein Society 1997;6(7):1529-36.
1996: Y N Chirgadze; H P Driessen; G Wright; Christine Slingsby; R E Hay; P F Lindley
Structure of bovine eye lens gammaD (gammaIIIb)-crystallin at 1.95 A.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 4):712-21.
1996: V S Kumaraswamy; P F Lindley; Christine Slingsby; I D Glover
An eye lens protein-water structure: 1.2 A resolution structure of gammaB-crystallin at 150 K.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 4):611-22.
1996: B V Norledge; EM Mayr; Rudi Glockshuber; O A Bateman; Christine Slingsby; Rainer Jaenicke; H P Driessen
The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins.
Nature structural biology 1996;3(3):267-74.
1995: Ronald H P H Smulders; K B Merck; J Aendekerk; J Horwitz; L Takemoto; Christine Slingsby; Hans Bloemendal; Wilfried W de Jong
The mutation Asp69-->Ser affects the chaperone-like activity of alpha A-crystallin.
European journal of biochemistry / FEBS 1995;232(3):834-8.
1995: A Simpson; D Moss; Christine Slingsby
The avian eye lens protein delta-crystallin shows a novel packing arrangement of tetramers in a supramolecular helix.
Structure (London, England : 1993) 1995;3(4):403-12.
1994: R C Kroone; G S Elliott; A Ferszt; Christine Slingsby; Nicolette H Lubsen; J G Schoenmakers
The role of the sequence extensions in beta-crystallin assembly.
Protein engineering 1994;7(11):1395-9.
1994: S Zarina; Christine Slingsby; R Jaenicke; Zafar H Zaidi; H Driessen; N Srinivasan
Three-dimensional model and quaternary structure of the human eye lens protein gamma S-crystallin based on beta- and gamma-crystallin X-ray coordinates and ultracentrifugation.
Protein science : a publication of the Protein Society 1994;3(10):1840-6.
1994: A Simpson; O Bateman; H Driessen; P Lindley; D Moss; S Mylvaganam; E Narebor; Christine Slingsby
The structure of avian eye lens delta-crystallin reveals a new fold for a superfamily of oligomeric enzymes.
Nature structural biology 1994;1(10):724-34.
1994: Christine Slingsby; O A Bateman
Formation and crystallization of the eye lens heterodimer beta B2-beta B3-crystallin.
Experimental eye research 1994;58(6):761-4.
1994: V Nalini; B Bax; H Driessen; David S Moss; P F Lindley; Christine Slingsby
Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and ordering of sequence extensions.
Journal of molecular biology 1994;236(4):1250-8.
1993: Christine Slingsby; O A Bateman; A Simpson
Motifs involved in protein-protein interactions.
Molecular biology reports 1993;17(3):185-95.
1993: S Najmudin; V Nalini; H P Driessen; Christine Slingsby; Tom L Blundell; David S Moss; P F Lindley
Structure of the bovine eye lens protein gammaB(gammaII)-crystallin at 1.47 A.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 2):223-33.
1992: O A Bateman; Christine Slingsby
Structural studies on beta H-crystallin from bovine eye lens.
Experimental eye research 1992;55(1):127-33.
1991: R Lapatto; V Nalini; B Bax; H Driessen; P F Lindley; Tom L Blundell; Christine Slingsby
High resolution structure of an oligomeric eye lens beta-crystallin. Loops, arches, linkers and interfaces in beta B2 dimer compared to a monomeric gamma-crystallin.
Journal of molecular biology 1991;222(4):1067-83.
1991: H P Driessen; B Bax; Christine Slingsby; P F Lindley; D Mahadevan; David S Moss; Ian Tickle
Structure of oligomeric beta B2-crystallin: an application of the T2 translation function to an asymmetric unit containing two dimers.
Acta crystallographica. Section B, Structural science 1991;47 ( Pt 6)():987-97.
1991: Christine Slingsby; A Simpson; A Ferszt; O A Bateman; V Nalini
Molecular interactions in the eye lens.
Biochemical Society transactions 1991;19(4):853-8.
1991: G L van Rens; H P Driessen; V Nalini; Christine Slingsby; Wilfried W de Jong; Hans Bloemendal
Isolation and characterization of cDNAs encoding beta A2- and beta A4-crystallins: heterologous interactions in the predicted beta A4-beta B2 heterodimer.
Gene 1991;102(2):179-88.
1990: B Bax; R Lapatto; V Nalini; H Driessen; P F Lindley; D Mahadevan; Tom L Blundell; Christine Slingsby
X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins.
Nature 1990;347(6295):776-80.
1990: Christine Slingsby; O A Bateman
Quaternary interactions in eye lens beta-crystallins: basic and acidic subunits of beta-crystallins favor heterologous association.
Biochemistry 1990;29(28):6592-9.
1990: Christine Slingsby; O A Bateman
Rapid separation of bovine beta-crystallin subunits beta B1, beta B2, beta B3, beta A3 and beta A4.
Experimental eye research 1990;51(1):21-6.
1989: B Bax; Christine Slingsby
Crystallization of a new form of the eye lens protein beta B2-crystallin.
Journal of molecular biology 1989;208(4):715-7.
1989: Helen E White; H P Driessen; Christine Slingsby; David S Moss; P F Lindley
Packing interactions in the eye-lens. Structural analysis, internal symmetry and lattice interactions of bovine gamma IVa-crystallin.
Journal of molecular biology 1989;207(1):217-35.
1988: Wiljan Hendriks; J W Mulders; M A Bibby; Christine Slingsby; Hans Bloemendal; Wilfried W de Jong
Duck lens epsilon-crystallin and lactate dehydrogenase B4 are identical: a single-copy gene product with two distinct functions.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7114-8.
1988: Helen E White; H P Driessen; Christine Slingsby; David S Moss; W G Turnell; P F Lindley
The use of pseudosymmetry in the rotation function of gamma IVa-crystallin.
Acta crystallographica. Section B, Structural science 1988;44 ( Pt 2)():172-8.
1988: Christine Slingsby; H P Driessen; D Mahadevan; B Bax; Tom L Blundell
Evolutionary and functional relationships between the basic and acidic beta-crystallins.
Experimental eye research 1988;46(3):375-403.
1988: Y V Sergeev; Y N Chirgadze; S E Mylvaganam; H Driessen; Christine Slingsby; T L Blundell
Surface interactions of gamma-crystallins in the crystal medium in relation to their association in the eye lens.
Proteins 1988;4(2):137-47.
1987: Iu V Sergeev; Iu N Chirgadze; H Driessen; Christine Slingsby; T L Blundell
[The key role of the residue 103 in the surface interactions of gamma-crystallins].
Molekuliarnaia biologiia 1987;21(2):377-81.
1984: L Summers; Christine Slingsby; H White; M Narebor; D Moss; L Miller; D Mahadevan; P Lindley; H Driessen; Tom L Blundell
The molecular structures and interactions of bovine and human gamma-crystallins.
Ciba Foundation symposium 1984;106():219-36.
1983: G Wistow; B Turnell; L Summers; Christine Slingsby; D Moss; L Miller; P Lindley; Tom L Blundell
X-ray analysis of the eye lens protein gamma-II crystallin at 1.9 A resolution.
Journal of molecular biology 1983;170(1):175-202.
1983: George Inana; J Piatigorsky; B Norman; Christine Slingsby; T Blundell
Gene and protein structure of a beta-crystallin polypeptide in murine lens: relationship of exons and structural motifs.
Nature 1983;302(5906):310-5.
1981: G Wistow; Christine Slingsby; T Blundell; H Driessen; W De Jong; Hans Bloemendal
Eye-lens proteins: the three-dimensional structure of beta-crystallin predicted from monomeric gamma-crystallin.
FEBS letters 1981;133(1):9-16.
1981: Tom L Blundell; P Lindley; L Miller; D Moss; Christine Slingsby; Ian Tickle; B Turnell; G Wistow
The molecular structure and stability of the eye lens: x-ray analysis of gamma-crystallin II.
Nature 1981;289(5800):771-7.
1980: E Narebor; Christine Slingsby; P F Lindley; T L Blundell
Preliminary x-ray crystallographic study of the turkey lens protein, delta-crystallin.
Journal of molecular biology 1980;143(2):223-5.