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AJ Slotboom

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Pancreas

Living Beings

Objects

Micelles

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

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Co-Publications
Name
13
Verheij, HM
12
Egmond, Maarten
7
Dekker, Nick
5
Boelens, Rolf
5
Kaptein, Robert
5
Op den Kamp, Jos
4
Janssen, Marcel
3
Boots, Jan-Willem
2
de Kruijff, Ben
2
Lubin, Bertram
2
Maliwal, Badri
2
Simons, JW
2
Vial, Henri
2
Ancelin, Marie Laure
1
Szmacinski, Henryk

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Publications

TOP 3
Koops B C; Papadimou E; Verheij H M; Slotboom A J; Egmond M R
Activity and stability of chemically modified Candida antarctica lipase B adsorbed on solid supports.
Janssen M J; Vermeulen L; Van der Helm H A; Aarsman A J; Slotboom A J; Egmond M R
Enzymatic properties of rat group IIA and V phospholipases A(2) compared.
Janssen M J; Burghout P J; Verheij H M; Slotboom A J; Egmond M R
Introduction of a C-terminal aromatic sequence from snake venom phospholipases A2 into the porcine pancreatic isozyme dramatically changes the interfacial kinetics.

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All Publications

1999: Koops B C; Papadimou E; Verheij H M; Slotboom A J; Egmond M R
Activity and stability of chemically modified Candida antarctica lipase B adsorbed on solid supports.
Applied microbiology and biotechnology 1999;52(6):791-6.
1999: Janssen M J; Vermeulen L; Van der Helm H A; Aarsman A J; Slotboom A J; Egmond M R
Enzymatic properties of rat group IIA and V phospholipases A(2) compared.
Biochimica et biophysica acta 1999;1440(1):59-72.
1999: Janssen M J; Burghout P J; Verheij H M; Slotboom A J; Egmond M R
Introduction of a C-terminal aromatic sequence from snake venom phospholipases A2 into the porcine pancreatic isozyme dramatically changes the interfacial kinetics.
European journal of biochemistry / FEBS 1999;263(3):782-8.
1999: Janssen M J; van de Wiel W A; Beiboer S H; van Kampen M D; Verheij H M; Slotboom A J; Egmond M R
Catalytic role of the active site histidine of porcine pancreatic phospholipase A2 probed by the variants H48Q, H48N and H48K.
Protein engineering 1999;12(6):497-503.
1999: Janssen M J; Verheij H M; Slotboom A J; Egmond M R
Engineering the disulphide bond patterns of secretory phospholipases A2 into porcine pancreatic isozyme. The effects on folding, stability and enzymatic properties.
European journal of biochemistry / FEBS 1999;261(1):197-207.
1997: Simons J W; Boots J W; Kats M P; Slotboom A J; Egmond M R; Verheij H M
Dissecting the catalytic mechanism of staphylococcal lipases using carbamate substrates: chain length selectivity, interfacial activation, and cofactor dependence.
Biochemistry 1997;36(47):14539-50.
1996: Simons J W; Adams H; Cox R C; Dekker N; Götz F; Slotboom A J; Verheij H M
The lipase from Staphylococcus aureus. Expression in Escherichia coli, large-scale purification and comparison of substrate specificity to Staphylococcus hyicus lipase.
European journal of biochemistry / FEBS 1996;242(3):760-9.
1996: Bekkers A C; Slotboom A J; van Willigen G; Akkerman J W; Verheij H M
Targeting of porcine pancreatic phospholipase A2 to human platelets. Introduction of an RGD sequence and acyl-group by chemical modification.
European journal of biochemistry / FEBS 1996;238(1):70-6.
1995: Mannesse M L; Boots J W; Dijkman R; Slotboom A J; van der Hijden H T; Egmond M R; Verheij H M; de Haas G H
Phosphonate analogues of triacylglycerols are potent inhibitors of lipase.
Biochimica et biophysica acta 1995;1259(1):56-64.
1995: Boots J W; van Dongen W D; Verheij H M; de Haas G H; Haverkamp J; Slotboom A J
Identification of the active site histidine in Staphylococcus hyicus lipase using chemical modification and mass spectrometry.
Biochimica et biophysica acta 1995;1248(1):27-34.
1994: Maliwal B P; Yu B Z; Szmacinski H; Squier T; van Binsbergen J; Slotboom A J; Jain M K
Functional significance of the conformational dynamics of the N-terminal segment of secreted phospholipase A2 at the interface.
Biochemistry 1994;33(15):4509-16.
1994: Leuveling Tjeenk M; Bulsink Y B; Slotboom A J; Verheij H M; de Haas G H; Demleitner G; Götz F
Inactivation of Staphylococcus hyicus lipase by hexadecylsulfonyl fluoride: evidence for an active site serine.
Protein engineering 1994;7(4):579-83.
1993: Lugtigheid R B; Nicolaes G A; Veldhuizen E J; Slotboom A J; Verheij H M; De Haas G H
Acylation of porcine pancreatic phospholipase A2 influences penetration and substrate head-group binding, depending on the position of the acylated lysine in the enzyme molecule.
European journal of biochemistry / FEBS 1993;216(2):519-25.
1992: Peters A R; Dekker N; van den Berg L; Boelens R; Kaptein R; Slotboom A J; de Haas G H
Conformational changes in phospholipase A2 upon binding to micellar interfaces in the absence and presence of competitive inhibitors. A 1H and 15N NMR study.
Biochemistry 1992;31(41):10024-30.
1992: Peters A R; Dekker N; van den Berg L; Boelens R; Slotboom A J; de Haas G H; Kaptein R
NMR studies of interactions between inhibitors and porcine pancreatic phospholipase A2.
Biochimie 1992;74(9-10):859-66.
1991: Dekker N; Peters A R; Slotboom A J; Boelens R; Kaptein R; Dijkman R; de Haas G
Two-dimensional 1H-NMR studies of phospholipase-A2-inhibitor complexes bound to a micellar lipid-water interface.
European journal of biochemistry / FEBS 1991;199(3):601-7.
1991: Simões A P; Moll G N; Slotboom A J; Roelofsen B; Op den Kamp J A
Selective internalization of choline-phospholipids in Plasmodium falciparum parasitized human erythrocytes.
Biochimica et biophysica acta 1991;1063(1):45-50.
1991: Dekker N; Peters A R; Slotboom A J; Boelens R; Kaptein R; de Haas G
Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N NMR assignments and secondary structure.
Biochemistry 1991;30(12):3135-46.
1991: Oudejans R C; Kooiman F P; Heerma W; Versluis C; Slotboom A J; Beenakkers M T
Isolation and structure elucidation of a novel adipokinetic hormone (Lom-AKH-III) from the glandular lobes of the corpus cardiacum of the migratory locust, Locusta migratoria.
European journal of biochemistry / FEBS 1991;195(2):351-9.
1990: Moll G N; Vial H J; van der Wiele F C; Ancelin M L; Roelofsen B; Slotboom A J; de Haas G H; van Deenen L L; Op den Kamp J A
Selective elimination of malaria infected erythrocytes by a modified phospholipase A2 in vitro.
Biochimica et biophysica acta 1990;1024(1):189-92.
1990: Moll G N; Vial H J; Bevers E M; Ancelin M L; Roelofsen B; Comfurius P; Slotboom A J; Zwaal R F; Op den Kamp J A; van Deenen L L
Phospholipid asymmetry in the plasma membrane of malaria infected erythrocytes.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(2):579-85.
1989: Fisher J; Primrose W U; Roberts G C; Dekker N; Boelens R; Kaptein R; Slotboom A J
1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution.
Biochemistry 1989;28(14):5939-46.
1989: Middlekoop E; Van der Hoek E E; Bevers E M; Comfurius P; Slotboom A J; Op den Kamp J A; Lubin B H; Zwaal R F; Roelofsen B
Involvement of ATP-dependent aminophospholipid translocation in maintaining phospholipid asymmetry in diamide-treated human erythrocytes.
Biochimica et biophysica acta 1989;981(1):151-60.
1989: van den Bergh C J; Slotboom A J; Verheij H M; de Haas G H
The role of Asp-49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activity.
Journal of cellular biochemistry 1989;39(4):379-90.
1989: van Binsbergen J; Slotboom A J; Aarsman A J; de Haas G H
Synthetic peptide from lipocortin I has no phospholipase A2 inhibitory activity.
FEBS letters 1989;247(2):293-7.
1989: Middelkoop E; Coppens A; Llanillo M; Van der Hoek E E; Slotboom A J; Lubin B H; Op den Kamp J A; Van Deenen L L; Roelofsen B
Aminophospholipid translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine.
Biochimica et biophysica acta 1989;978(2):241-8.
1988: van der Wiele F C; Dekker N; Van Scharrenburg G J; Hartskeerl R A; Meijer H; De Haas G H; Van Deenen L L; Slotboom A J
Effect of selective chemical modification and CNBr-cleavage at methionine20 in catalytic activity and substrate binding properties of porcine pancreatic phospholipase A2.
Biochimie 1988;70(9):1215-22.
1988: van den Bergh C J; Slotboom A J; Verheij H M; de Haas G H
The role of aspartic acid-49 in the active site of phospholipase A2. A site-specific mutagenesis study of porcine pancreatic phospholipase A2 and the rationale of the enzymatic activity of [lysine49]phospholipase A2 from Agkistrodon piscivorus piscivorus' venom.
European journal of biochemistry / FEBS 1988;176(2):353-7.
1988: Van der Wiele F C; Atsma W; Roelofsen B; van Linde M; Van Binsbergen J; Radvanyi F; Raykova D; Slotboom A J; De Haas G H
Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 2. Transformation of soluble phospholipase A2 into a highly penetrating "membrane-bound" form.
Biochemistry 1988;27(5):1688-94.
1988: Van der Wiele F C; Atsma W; Dijkman R; Schreurs A M; Slotboom A J; De Haas G H
Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 1. Preparation and properties.
Biochemistry 1988;27(5):1683-8.
1988: Batenburg A M; Brasseur R; Ruysschaert J M; van Scharrenburg G J; Slotboom A J; Demel R A; de Kruijff B
Characterization of the interfacial behavior and structure of the signal sequence of Escherichia coli outer membrane pore protein PhoE.
The Journal of biological chemistry 1988;263(9):4202-7.
1987: de Haas G H; van Scharrenburg G J; Slotboom A J
Interaction of pancreatic phospholipases A2 and semisynthetic mutants with anionic substrates and substrate analogues.
Biochemistry 1987;26(12):3402-8.
1986: Jain M K; Maliwal B P; DeHaas G H; Slotboom A J
Anchoring of phospholipase A2: the effect of anions and deuterated water, and the role of N-terminus region.
Biochimica et biophysica acta 1986;860(3):448-61.
1986: Killian J A; van den Berg C W; Tournois H; Keur S; Slotboom A J; van Scharrenburg G J; de Kruijff B
Gramicidin-induced hexagonal HII phase formation in negatively charged phospholipids and the effect of N- and C-terminal modification of gramicidin on its interaction with zwitterionic phospholipids.
Biochimica et biophysica acta 1986;857(1):13-27.
1985: Allegrini P R; van Scharrenburg G J; Slotboom A J; de Haas G H; Seelig J
Side-chain dynamics of two aromatic amino acids in pancreatic phospholipase A2 as studied by deuterium nuclear magnetic resonance.
Biochemistry 1985;24(13):3268-73.
1985: van Scharrenburg G J; Slotboom A J; de Haas G H; Mulqueen P; Breen P J; Horrocks W D
Catalytic Ca2+-binding site of pancreatic phospholipase A2: laser-induced Eu3+ luminescence study.
Biochemistry 1985;24(2):334-9.
1984: van Scharrenburg G J; Jansen E H; Egmond M R; de Haas G H; Slotboom A J
Structural importance of the amino-terminal residue of pancreatic phospholipase A2.
Biochemistry 1984;23(25):6285-94.
1984: Dijkstra B W; Kalk K H; Drenth J; de Haas G H; Egmond M R; Slotboom A J
Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2.
Biochemistry 1984;23(12):2759-66.
1983: van Scharrenburg G J; Puijk W C; de Haas G H; Slotboom A J
Semisynthesis of phospholipase A2. The effect of substitution of amino-acid residues at positions 6 and 7 in bovine and porcine pancreatic phospholipases A2 on catalytic and substrate-binding properties.
European journal of biochemistry / FEBS 1983;133(1):83-9.
1982: van Scharrenburg G J; Puijk W C; Egmond M R; van der Schaft P H; de Haas G H; Slotboom A J
Effects of substitution of the absolutely invariant glutamine-4 and phenylalanine-5 in bovine pancreatic phospholipase A2 on enzymatic activity and substrate binding properties.
Biochemistry 1982;21(6):1345-52.
1981: Fleer E A; Puijk W C; Slotboom A J; de Haas G H
Modification of arginine residues in porcine pancreatic phospholipase A2.
European journal of biochemistry / FEBS 1981;116(2):277-84.
1981: van Scharrenburg G J; Puijk W C; Egmond M R; de Haas G H; Slotboom A J
Semisynthesis of phospholipase A2. Preparation and properties of arginine-6 bovine pancreatic phospholipase A2.
Biochemistry 1981;20(6):1584-91.
1981: de Metz M; Vermeer C; Soute B A; van Scharrenburg G J; Slotboom A J; Hemker H C
Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X.
FEBS letters 1981;123(2):215-8.
1980: Egmond M R; Slotboom A J; De Haas G H; Dijkstra K; Kaptein R
1H-NMR and photochemically-induced dynamic nuclear polarization studies on bovine pancreatic phospholipase A2.
Biochimica et biophysica acta 1980;623(2):461-6.
1980: van Scharrenburg G J; de Haas G H; Slotboom A J
Regeneration of full enzymatic activity by reoxidation of reduced pancreatic phospholipase A2.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1980;361(4):571-6.

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