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AJ Slotboom

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TOP 3
B C Koops; E Papadimou; HM Verheij; AJ Slotboom; Maarten R Egmond
Activity and stability of chemically modified Candida antarctica lipase B adsorbed on solid supports.
Marcel J W Janssen; L Vermeulen; HA Van der Helm; AJ Aarsman; AJ Slotboom; Maarten R Egmond
Enzymatic properties of rat group IIA and V phospholipases A(2) compared.
Marcel J W Janssen; Peter Burghout; HM Verheij; AJ Slotboom; Maarten R Egmond
Introduction of a C-terminal aromatic sequence from snake venom phospholipases A2 into the porcine pancreatic isozyme dramatically changes the interfacial kinetics.

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All Publications

1999: B C Koops; E Papadimou; HM Verheij; AJ Slotboom; Maarten R Egmond
Activity and stability of chemically modified Candida antarctica lipase B adsorbed on solid supports.
Applied microbiology and biotechnology 1999;52(6):791-6.
1999: Marcel J W Janssen; L Vermeulen; HA Van der Helm; AJ Aarsman; AJ Slotboom; Maarten R Egmond
Enzymatic properties of rat group IIA and V phospholipases A(2) compared.
Biochimica et biophysica acta 1999;1440(1):59-72.
1999: Marcel J W Janssen; Peter Burghout; HM Verheij; AJ Slotboom; Maarten R Egmond
Introduction of a C-terminal aromatic sequence from snake venom phospholipases A2 into the porcine pancreatic isozyme dramatically changes the interfacial kinetics.
European journal of biochemistry / FEBS 1999;263(3):782-8.
1999: Marcel J W Janssen; W A van de Wiel; S H Beiboer; MD van Kampen; HM Verheij; AJ Slotboom; Maarten R Egmond
Catalytic role of the active site histidine of porcine pancreatic phospholipase A2 probed by the variants H48Q, H48N and H48K.
Protein engineering 1999;12(6):497-503.
1999: Marcel J W Janssen; HM Verheij; AJ Slotboom; Maarten R Egmond
Engineering the disulphide bond patterns of secretory phospholipases A2 into porcine pancreatic isozyme. The effects on folding, stability and enzymatic properties.
European journal of biochemistry / FEBS 1999;261(1):197-207.
1997: JW Simons; Jan-Willem P Boots; M P Kats; AJ Slotboom; Maarten R Egmond; HM Verheij
Dissecting the catalytic mechanism of staphylococcal lipases using carbamate substrates: chain length selectivity, interfacial activation, and cofactor dependence.
Biochemistry 1997;36(47):14539-50.
1996: JW Simons; H Adams; RC Cox; Nick Dekker; F Götz; AJ Slotboom; HM Verheij
The lipase from Staphylococcus aureus. Expression in Escherichia coli, large-scale purification and comparison of substrate specificity to Staphylococcus hyicus lipase.
European journal of biochemistry / FEBS 1996;242(3):760-9.
1996: A C Bekkers; AJ Slotboom; Gijsbert van Willigen; Jan-Willem N Akkerman; HM Verheij
Targeting of porcine pancreatic phospholipase A2 to human platelets. Introduction of an RGD sequence and acyl-group by chemical modification.
European journal of biochemistry / FEBS 1996;238(1):70-6.
1995: Maurice Mannesse; Jan-Willem P Boots; R Dijkman; AJ Slotboom; HT van der Hijden; Maarten R Egmond; HM Verheij; G H de Haas
Phosphonate analogues of triacylglycerols are potent inhibitors of lipase.
Biochimica et biophysica acta 1995;1259(1):56-64.
1995: Jan-Willem P Boots; W D van Dongen; HM Verheij; G H de Haas; Johan Haverkamp; AJ Slotboom
Identification of the active site histidine in Staphylococcus hyicus lipase using chemical modification and mass spectrometry.
Biochimica et biophysica acta 1995;1248(1):27-34.
1994: Badri P Maliwal; B Z Yu; Henryk Szmacinski; Thomas C Squier; J van Binsbergen; AJ Slotboom; M K Jain
Functional significance of the conformational dynamics of the N-terminal segment of secreted phospholipase A2 at the interface.
Biochemistry 1994;33(15):4509-16.
1994: M Leuveling Tjeenk; Y B Bulsink; AJ Slotboom; HM Verheij; G H de Haas; G Demleitner; F Götz
Inactivation of Staphylococcus hyicus lipase by hexadecylsulfonyl fluoride: evidence for an active site serine.
Protein engineering 1994;7(4):579-83.
1993: R B Lugtigheid; G A Nicolaes; E J Veldhuizen; AJ Slotboom; HM Verheij; G H De Haas
Acylation of porcine pancreatic phospholipase A2 influences penetration and substrate head-group binding, depending on the position of the acylated lysine in the enzyme molecule.
European journal of biochemistry / FEBS 1993;216(2):519-25.
1992: A R Peters; Nick Dekker; L van den Berg; Rolf Boelens; Robert Kaptein; AJ Slotboom; G H de Haas
Conformational changes in phospholipase A2 upon binding to micellar interfaces in the absence and presence of competitive inhibitors. A 1H and 15N NMR study.
Biochemistry 1992;31(41):10024-30.
1992: A R Peters; Nick Dekker; L van den Berg; Rolf Boelens; AJ Slotboom; G H de Haas; Robert Kaptein
NMR studies of interactions between inhibitors and porcine pancreatic phospholipase A2.
Biochimie 1992;74(9-10):859-66.
1991: Nick Dekker; A R Peters; AJ Slotboom; Rolf Boelens; Robert Kaptein; R Dijkman; G de Haas
Two-dimensional 1H-NMR studies of phospholipase-A2-inhibitor complexes bound to a micellar lipid-water interface.
European journal of biochemistry / FEBS 1991;199(3):601-7.
1991: Nick Dekker; A R Peters; AJ Slotboom; Rolf Boelens; Robert Kaptein; G de Haas
Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N NMR assignments and secondary structure.
Biochemistry 1991;30(12):3135-46.
1991: A P Simões; G N Moll; AJ Slotboom; B Roelofsen; Jos A F Op den Kamp
Selective internalization of choline-phospholipids in Plasmodium falciparum parasitized human erythrocytes.
Biochimica et biophysica acta 1991;1063(1):45-50.
1991: Rob C H M Oudejans; F P Kooiman; W Heerma; Cees Versluis; AJ Slotboom; M T Beenakkers
Isolation and structure elucidation of a novel adipokinetic hormone (Lom-AKH-III) from the glandular lobes of the corpus cardiacum of the migratory locust, Locusta migratoria.
European journal of biochemistry / FEBS 1991;195(2):351-9.
1990: G N Moll; Henri VIAL; F C van der Wiele; Marie Laure Ancelin; B Roelofsen; AJ Slotboom; G H de Haas; L L van Deenen; Jos A F Op den Kamp
Selective elimination of malaria infected erythrocytes by a modified phospholipase A2 in vitro.
Biochimica et biophysica acta 1990;1024(1):189-92.
1990: G N Moll; Henri VIAL; E M Bevers; Marie Laure Ancelin; B Roelofsen; P Comfurius; AJ Slotboom; R F Zwaal; Jos A F Op den Kamp; L L van Deenen
Phospholipid asymmetry in the plasma membrane of malaria infected erythrocytes.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(2):579-85.
1989: J Fisher; WU Primrose; Gordon Roberts; Nick Dekker; Rolf Boelens; Robert Kaptein; AJ Slotboom
1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution.
Biochemistry 1989;28(14):5939-46.
1989: E Middlekoop; E E Van der Hoek; E M Bevers; P Comfurius; AJ Slotboom; Jos A F Op den Kamp; Bertram H Lubin; R F Zwaal; B Roelofsen
Involvement of ATP-dependent aminophospholipid translocation in maintaining phospholipid asymmetry in diamide-treated human erythrocytes.
Biochimica et biophysica acta 1989;981(1):151-60.
1989: J van Binsbergen; AJ Slotboom; A J Aarsman; G H de Haas
Synthetic peptide from lipocortin I has no phospholipase A2 inhibitory activity.
FEBS letters 1989;247(2):293-7.
1989: C J van den Bergh; AJ Slotboom; HM Verheij; G H de Haas
The role of Asp-49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activity.
Journal of cellular biochemistry 1989;39(4):379-90.
1989: E Middelkoop; A Coppens; M Llanillo; E E Van der Hoek; AJ Slotboom; Bertram H Lubin; Jos A F Op den Kamp; L L Van Deenen; B Roelofsen
Aminophospholipid translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine.
Biochimica et biophysica acta 1989;978(2):241-8.
1988: C J van den Bergh; AJ Slotboom; HM Verheij; G H de Haas
The role of aspartic acid-49 in the active site of phospholipase A2. A site-specific mutagenesis study of porcine pancreatic phospholipase A2 and the rationale of the enzymatic activity of [lysine49]phospholipase A2 from Agkistrodon piscivorus piscivorus' venom.
European journal of biochemistry / FEBS 1988;176(2):353-7.
1988: F C van der Wiele; Nick Dekker; G J Van Scharrenburg; R A Hartskeerl; H Meijer; G H De Haas; L L Van Deenen; AJ Slotboom
Effect of selective chemical modification and CNBr-cleavage at methionine20 in catalytic activity and substrate binding properties of porcine pancreatic phospholipase A2.
Biochimie 1988;70(9):1215-22.
1988: A M Batenburg; R Brasseur; J M Ruysschaert; G J van Scharrenburg; AJ Slotboom; Rudy A Demel; Ben de Kruijff
Characterization of the interfacial behavior and structure of the signal sequence of Escherichia coli outer membrane pore protein PhoE.
The Journal of biological chemistry 1988;263(9):4202-7.
1988: F C Van der Wiele; W Atsma; B Roelofsen; M van Linde; J Van Binsbergen; F Radvanyi; D Raykova; AJ Slotboom; G H De Haas
Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 2. Transformation of soluble phospholipase A2 into a highly penetrating "membrane-bound" form.
Biochemistry 1988;27(5):1688-94.
1988: F C Van der Wiele; W Atsma; R Dijkman; A M Schreurs; AJ Slotboom; G H De Haas
Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 1. Preparation and properties.
Biochemistry 1988;27(5):1683-8.
1987: G H de Haas; G J van Scharrenburg; AJ Slotboom
Interaction of pancreatic phospholipases A2 and semisynthetic mutants with anionic substrates and substrate analogues.
Biochemistry 1987;26(12):3402-8.
1986: M K Jain; Badri P Maliwal; G H DeHaas; AJ Slotboom
Anchoring of phospholipase A2: the effect of anions and deuterated water, and the role of N-terminus region.
Biochimica et biophysica acta 1986;860(3):448-61.
1986: J Antoinette Killian; C W van den Berg; H Tournois; S Keur; AJ Slotboom; G J van Scharrenburg; Ben de Kruijff
Gramicidin-induced hexagonal HII phase formation in negatively charged phospholipids and the effect of N- and C-terminal modification of gramicidin on its interaction with zwitterionic phospholipids.
Biochimica et biophysica acta 1986;857(1):13-27.
1985: P R Allegrini; G J van Scharrenburg; AJ Slotboom; G H de Haas; J Seelig
Side-chain dynamics of two aromatic amino acids in pancreatic phospholipase A2 as studied by deuterium nuclear magnetic resonance.
Biochemistry 1985;24(13):3268-73.
1985: G J van Scharrenburg; AJ Slotboom; G H de Haas; P Mulqueen; P J Breen; W D Horrocks
Catalytic Ca2+-binding site of pancreatic phospholipase A2: laser-induced Eu3+ luminescence study.
Biochemistry 1985;24(2):334-9.
1984: G J van Scharrenburg; E H Jansen; Maarten R Egmond; G H de Haas; AJ Slotboom
Structural importance of the amino-terminal residue of pancreatic phospholipase A2.
Biochemistry 1984;23(25):6285-94.
1984: B W Dijkstra; K H Kalk; J Drenth; G H de Haas; Maarten R Egmond; AJ Slotboom
Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2.
Biochemistry 1984;23(12):2759-66.
1983: G J van Scharrenburg; W C Puijk; G H de Haas; AJ Slotboom
Semisynthesis of phospholipase A2. The effect of substitution of amino-acid residues at positions 6 and 7 in bovine and porcine pancreatic phospholipases A2 on catalytic and substrate-binding properties.
European journal of biochemistry / FEBS 1983;133(1):83-9.
1982: G J van Scharrenburg; W C Puijk; Maarten R Egmond; P H van der Schaft; G H de Haas; AJ Slotboom
Effects of substitution of the absolutely invariant glutamine-4 and phenylalanine-5 in bovine pancreatic phospholipase A2 on enzymatic activity and substrate binding properties.
Biochemistry 1982;21(6):1345-52.
1981: E A Fleer; W C Puijk; AJ Slotboom; G H de Haas
Modification of arginine residues in porcine pancreatic phospholipase A2.
European journal of biochemistry / FEBS 1981;116(2):277-84.
1981: G J van Scharrenburg; W C Puijk; Maarten R Egmond; G H de Haas; AJ Slotboom
Semisynthesis of phospholipase A2. Preparation and properties of arginine-6 bovine pancreatic phospholipase A2.
Biochemistry 1981;20(6):1584-91.
1981: M de Metz; C Vermeer; B A Soute; G J van Scharrenburg; AJ Slotboom; H C Hemker
Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X.
FEBS letters 1981;123(2):215-8.
1980: Maarten R Egmond; AJ Slotboom; G H De Haas; K Dijkstra; R Kaptein
1H-NMR and photochemically-induced dynamic nuclear polarization studies on bovine pancreatic phospholipase A2.
Biochimica et biophysica acta 1980;623(2):461-6.
1980: G J van Scharrenburg; G H de Haas; AJ Slotboom
Regeneration of full enzymatic activity by reoxidation of reduced pancreatic phospholipase A2.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1980;361(4):571-6.