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Tom Smeets

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Carla A Wijbrandts; Philip H Remans; Paul L Klarenbeek; Diana Wouters; Marius A van den Bergh Weerman; Tom J M Smeets; Margriet J Vervoordeldonk; Dominique Baeten; Paul P Tak
Analysis of apoptosis in peripheral blood and synovial tissue very early after initiation of infliximab treatment in rheumatoid arthritis patients.
C A Wijbrandts; Marcel GW Dijkgraaf; Maarten C Kraan; Marjolein Vinkenoog; Tom J M Smeets; Huibert J Dinant; K Vos; W F Lems; G J Wolbink; D Sijpkens; B A C Dijkmans; Paul P Tak
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium.
M Cristina Lebre; Sarah L Jongbloed; Sander W Tas; Tom J M Smeets; Iain B McInnes; Paul P Tak
Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles.

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All Publications

2008: Carla A Wijbrandts; Philip H Remans; Paul L Klarenbeek; Diana Wouters; Marius A van den Bergh Weerman; Tom J M Smeets; Margriet J Vervoordeldonk; Dominique Baeten; Paul P Tak
Analysis of apoptosis in peripheral blood and synovial tissue very early after initiation of infliximab treatment in rheumatoid arthritis patients.
Arthritis and rheumatism 2008;58(11):3330-9.
2008: C A Wijbrandts; Marcel GW Dijkgraaf; Maarten C Kraan; Marjolein Vinkenoog; Tom J M Smeets; Huibert J Dinant; K Vos; W F Lems; G J Wolbink; D Sijpkens; B A C Dijkmans; Paul P Tak
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium.
Annals of the rheumatic diseases 2008;67(8):1139-44.
2008: M Cristina Lebre; Sarah L Jongbloed; Sander W Tas; Tom J M Smeets; Iain B McInnes; Paul P Tak
Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles.
The American journal of pathology 2008;172(4):940-50.
2007: Clarissa E Vergunst; Danielle M Gerlag; Huibert J Dinant; L Schulz; Marjolein Vinkenoog; Tom J M Smeets; Marjolein E Sanders; Kris A Reedquist; Paul P Tak
Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation.
Rheumatology (Oxford, England) 2007;46(12):1773-8.
2007: Carla A Wijbrandts; Clarissa E Vergunst; Jasper J Haringman; Danielle M Gerlag; Tom J M Smeets; Paul P Tak
Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker.
Arthritis and rheumatism 2007;56(11):3869-71.
2007: J Ludikhuize; D de Launay; D Groot; Tom J M Smeets; Marjolein Vinkenoog; Marjolein E Sanders; Sander W Tas; Paul P Tak; Kris A Reedquist
Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue.
Arthritis and rheumatism 2007;56(7):2180-91.
2007: Barry Bresnihan; Danielle M Gerlag; Terence Rooney; Tom J M Smeets; Carla A Wijbrandts; David Boyle; Oliver FitzGerald; Bruce W Kirkham; Iain B McInnes; Malcolm Smith; Ann-Kristin Ulfgren; douglas veale; Paul P Tak
Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.
The Journal of rheumatology 2007;34(3):620-2.
2007: David A Brown; John Moore; Heiko Johnen; Tom J M Smeets; Asne R Bauskin; Tamara Kuffner; Helen Weedon; Samuel T Milliken; Paul P Tak; Malcolm D Smith; Samuel N Breit
Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction.
Arthritis and rheumatism 2007;56(3):753-64.
2006: Arno W R van Kuijk; P Reinders-Blankert; Tom J M Smeets; B A C Dijkmans; Paul P Tak
Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment.
Annals of the rheumatic diseases 2006;65(12):1551-7.
2006: Zalima N Jahangier; J W G Jacobs; Maarten C Kraan; M J G Wenting; Tom J M Smeets; J W J Bijlsma; Floris P J G Lafeber; P P Tak
Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids.
Annals of the rheumatic diseases 2006;65(10):1286-92.
2006: Jasper J Haringman; Danielle M Gerlag; Tom J M Smeets; Dominique Baeten; Filip van den Bosch; Barry Bresnihan; Ferdinand C Breedveld; Huibert J Dinant; Francois Legay; Hermann Gram; Pius Loetscher; Robert Schmouder; Thasia Woodworth; Paul P Tak
A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis.
Arthritis and rheumatism 2006;54(8):2387-92.
2006: Jasper J Haringman; Tom J M Smeets; P Reinders-Blankert; Paul P Tak
Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis.
Annals of the rheumatic diseases 2006;65(3):294-300.
2006: Else N Kop; Janik Adriaansen; Tom J M Smeets; Margriet J Vervoordeldonk; René A W van Lier; Jörg Hamann; Paul P Tak
CD97 neutralisation increases resistance to collagen-induced arthritis in mice.
Arthritis research & therapy 2006;8(5):R155.
2005: Judith van Holten; Tom J M Smeets; P Blankert; Paul P Tak
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis.
Annals of the rheumatic diseases 2005;64(12):1780-2.
2005: P H J Remans; Matthijs F M van Oosterhout; Tom J M Smeets; M Sanders; Wilma M Frederiks; Kris A Reedquist; Paul P Tak; Ferdinand C Breedveld; Jacob M van Laar
Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis.
Arthritis and rheumatism 2005;52(7):2003-9.
2005: Jasper J Haringman; Danielle M Gerlag; Aeilko H Zwinderman; Tom J M Smeets; Maarten C Kraan; Dominique Baeten; Iain B McInnes; Barry Bresnihan; Paul P Tak
Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(6):834-8.
2005: E J A Kroot; Maarten C Kraan; Tom J M Smeets; M Maas; P P Tak; J M G W Wouters
Tumour necrosis factor alpha blockade in treatment resistant pigmented villonodular synovitis.
Annals of the rheumatic diseases 2005;64(3):497-9.
2005: Else N Kop; Mark J Kwakkenbos; Gwendoline J D Teske; Maarten C Kraan; Tom J M Smeets; Martin Stacey; Hsi-Hsien Lin; Paul P Tak; Jörg Hamann
Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue.
Arthritis and rheumatism 2005;52(2):442-50.
2005: Pia Kasperkovitz; Trieneke C G Timmer; Tom J M Smeets; Nicolette L Verbeet; Paul P Tak; Lisa G M van Baarsen; Belinda Baltus; Tom W J Huizinga; Elsbet Pieterman; Michael Fero; Gary S Firestein; Tineke C T M van der Pouw Kraan; Cornelis L Verweij
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis.
Arthritis and rheumatism 2005;52(2):430-41.
2005: Jasper J Haringman; Marjolein Vinkenoog; Danielle M Gerlag; Tom J M Smeets; Aeilko H Zwinderman; Paul P Tak
Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis.
Arthritis research & therapy 2005;7(4):R862-7.
2005: René Berckmans; Rienk Nieuwland; Maarten C Kraan; Marianne C L Schaap; Desirée Pots; Tom J M Smeets; Augueste Sturk; Paul P Tak
Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes.
Arthritis research & therapy 2005;7(3):R536-44.
2004: Danielle M Gerlag; Jasper J Haringman; Tom J M Smeets; Aeilko H Zwinderman; Maarten C Kraan; Peter J Laud; Shethah Morgan; Anthony F P Nash; Paul P Tak
Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(12):3783-91.
2004: Erik R Vossenaar; Tom J M Smeets; Maarten C Kraan; Jos M H Raats; Walther J van Venrooij; Paul P Tak
The presence of citrullinated proteins is not specific for rheumatoid synovial tissue.
Arthritis and rheumatism 2004;50(11):3485-94.
2004: Maarten C Kraan; Tom J M Smeets; M J van Loon; Ferdinand C Breedveld; B A C Dijkmans; Paul P Tak
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(9):1056-61.
2004: Maarten C Kraan; Jasper J Haringman; Helen Weedon; EC Barg; Malcolm D Smith; Michael J Ahern; Tom J M Smeets; Ferdinand C Breedveld; Paul P Tak
T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(5):483-8.
2004: Pia Kasperkovitz; Nicolette L Verbeet; Tom J M Smeets; J G I van Rietschoten; Maarten C Kraan; Tineke C T M van der Pouw Kraan; Paul P Tak; Cornelis L Verweij
Activation of the STAT1 pathway in rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(3):233-9.
2004: Judith van Holten; Kris A Reedquist; Pascale Sattonet-Roche; Tom J M Smeets; Christine Plater-Zyberk; Margriet J Vervoordeldonk; Paul P Tak
Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis.
Arthritis research & therapy 2004;6(3):R239-49.
2003: Tom J M Smeets; Maarten C Kraan; Marieke E van Loon; Paul P Tak
Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue.
Arthritis and rheumatism 2003;48(8):2155-62.
2003: Tineke C T M van der Pouw Kraan; Floris A van Gaalen; Pia Kasperkovitz; Nicolette L Verbeet; Tom J M Smeets; Maarten C Kraan; Michael Fero; Paul P Tak; Tom W J Huizinga; Elsbet Pieterman; Ferdinand C Breedveld; Ash A Alizadeh; Cornelis L Verweij
Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues.
Arthritis and rheumatism 2003;48(8):2132-45.
2003: Jasper J Haringman; Maarten C Kraan; Tom J M Smeets; Koos H Zwinderman; Paul P Tak
Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(8):715-21.
2003: Tom J M Smeets; EC Barg; Maarten C Kraan; Malcolm D Smith; Ferdinand C Breedveld; Paul P Tak
Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(7):635-8.
2003: Malcolm D Smith; EC Barg; Helen Weedon; V Papengelis; Tom J M Smeets; Paul P Tak; Maarten C Kraan; Mark Coleman; Michael J Ahern
Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints.
Annals of the rheumatic diseases 2003;62(4):303-7.
2002: Tom J M Smeets; Erik R Vossenaar; Walther J van Venrooij; P P Tak
Is expression of intracellular citrullinated proteins in synovial tissue specific for rheumatoid arthritis? Comment on the article by Baeten et al.
Arthritis and rheumatism 2002;46(10):2824-6; author reply 2826-7.
2002: Maarten C Kraan; Arno W R van Kuijk; Huibert J Dinant; Amber Y Goedkoop; Tom J M Smeets; Menno A de Rie; B A C Dijkmans; Akshay K Vaishnaw; Jan D Bos; Paul P Tak
Alefacept treatment in psoriatic arthritis: reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis.
Arthritis and rheumatism 2002;46(10):2776-84.
2002: Maarten C Kraan; Richard J Reece; Tom J M Smeets; douglas veale; Paul Emery; Paul P Tak
Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment.
Arthritis and rheumatism 2002;46(8):2034-8.
2002: D M C Brinkman; Rebecca ten Cate; Jaak M Vossen; Tom J M Smeets; Maarten C Kraan; Paul P Tak
Decrease in synovial cellularity and cytokine expression after autologous stem cell transplantation in patients with juvenile idiopathic arthritis.
Arthritis and rheumatism 2002;46(4):1121-3.
2001: Amel Katrib; Paul P Tak; James V Bertouch; Carolyn Cuello; H Patrick McNeil; Tom J M Smeets; Maarten C Kraan; Peter P Youssef
Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis.
Rheumatology (Oxford, England) 2001;40(9):988-94.
2001: Tom J M Smeets; Maarten C Kraan; S Galjaard; Peter P Youssef; Malcolm D Smith; Paul P Tak
Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA.
Annals of the rheumatic diseases 2001;60(6):561-5.
2000: Maarten C Kraan; R J Reece; EC Barg; Tom J M Smeets; J Farnell; R Rosenburg; douglas veale; Ferdinand C Breedveld; P Emery; Paul P Tak
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers.
Arthritis and rheumatism 2000;43(8):1820-30.
2000: P C Verschueren; Alexandre E Voskuyl; Tom J M Smeets; Koos H Zwinderman; Ferdinand C Breedveld; Paul P Tak
Increased cellularity and expression of adhesion molecules in muscle biopsy specimens from patients with rheumatoid arthritis with clinical suspicion of vasculitis, but negative routine histology.
Annals of the rheumatic diseases 2000;59(8):598-606.
2000: Tom J M Smeets; J M Dayer; Maarten C Kraan; J Versendaal; R Chicheportiche; Ferdinand C Breedveld; Paul P Tak
The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis.
Arthritis and rheumatism 2000;43(2):270-4.
1999: Tom J M Smeets; Maarten C Kraan; J Versendaal; Ferdinand C Breedveld; Paul P Tak
Analysis of serial synovial biopsies in patients with rheumatoid arthritis: description of a control group without clinical improvement after treatment with interleukin 10 or placebo.
The Journal of rheumatology 1999;26(10):2089-93.
1999: Paul P Tak; Tom J M Smeets; David L Boyle; Maarten C Kraan; Y Shi; S Zhuang; Nathan J Zvaifler; F C Breedveld; Gary S Firestein
p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis.
Arthritis and rheumatism 1999;42(5):948-53.
1999: Paul P Tak; BA Hart; Maarten C Kraan; margreet jonker; Tom J M Smeets; Ferdinand C Breedveld
The effects of interferon beta treatment on arthritis.
Rheumatology (Oxford, England) 1999;38(4):362-9.
1999: Jörg Hamann; J O Wishaupt; René A W van Lier; Tom J M Smeets; Ferdinand C Breedveld; Paul P Tak
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue.
Arthritis and rheumatism 1999;42(4):650-8.
1998: Tom J M Smeets; R J E M Dolhain; Ferdinand C Breedveld; Paul P Tak
Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis.
The Journal of pathology 1998;186(1):75-81.
1998: Peter P Youssef; Tom J M Smeets; Barry Bresnihan; Gaye Cunnane; Oliver FitzGerald; F Breedveld; Paul P Tak
Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis.
British journal of rheumatology 1998;37(9):1003-7.
1997: E W Thurkow; IM van der Heijden; Ferdinand C Breedveld; Tom J M Smeets; M R Daha; P M Kluin; A E Meinders; Paul P Tak
Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis.
The Journal of pathology 1997;181(4):444-50.
1997: Paul P Tak; Tom J M Smeets; M R Daha; P M Kluin; K A Meijers; Ronald Brand; A E Meinders; Ferdinand C Breedveld
Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity.
Arthritis and rheumatism 1997;40(2):217-25.
1996: Paul P Tak; R Q Hintzen; J J Teunissen; Tom J M Smeets; Mohamed R Daha; René A W van Lier; P M Kluin; A E Meinders; A J Swaak; Ferdinand C Breedveld
Expression of the activation antigen CD27 in rheumatoid arthritis.
Clinical immunology and immunopathology 1996;80(2):129-38.
1996: Paul P Tak; P C Taylor; Ferdinand C Breedveld; Tom J M Smeets; Mohamed R Daha; Philip M Kluin; A E Meinders; R N Maini
Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis.
Arthritis and rheumatism 1996;39(7):1077-81.
1995: Paul P Tak; E W Thurkow; Mohamed R Daha; P M Kluin; Tom J M Smeets; A E Meinders; Ferdinand C Breedveld
Expression of adhesion molecules in early rheumatoid synovial tissue.
Clinical immunology and immunopathology 1995;77(3):236-42.
1995: Paul P Tak; Peter A H M van der Lubbe; A Cauli; Mohamed R Daha; Tom J M Smeets; Philip M Kluin; A E Meinders; G Yanni; Gabriel S Panayi; Ferdinand C Breedveld
Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis.
Arthritis and rheumatism 1995;38(10):1457-65.
1994: Paul P Tak; J Alain Kummer; C Erik Hack; Mohamed R Daha; Tom J M Smeets; G W Erkelens; A E Meinders; Philip M Kluin; Ferdinand C Breedveld
Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue.
Arthritis and rheumatism 1994;37(12):1735-43.