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Martine Smit

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Maussang David; Vischer Henry F; Leurs Rob; Smit Martine J
Herpesvirus-encoded G protein-coupled receptors as modulators of cellular function.
de Kruijf Petra; van Heteren Jane; Lim Herman D; Conti Paolo G M; van der Lee Miranda M C; Bosch Leontien; Ho Koc-Kan; Auld Douglas; Ohlmeyer Michael; Smit Martin J; Wijkmans Jac C H M; Zaman Guido J R; Smit Martine J; Leurs Rob
Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor.
Maussang David; Langemeijer Ellen; Fitzsimons Carlos P; Stigter-van Walsum Marijke; Dijkman Remco; Borg Martin K; Slinger Erik; Schreiber Andreas; Michel Detlef; Tensen Cornelis P; van Dongen Guus A M S; Leurs Rob; Smit Martine J
The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2.

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All Publications

2009: Maussang David; Vischer Henry F; Leurs Rob; Smit Martine J
Herpesvirus-encoded G protein-coupled receptors as modulators of cellular function.
Molecular pharmacology 2009;76(4):692-701.
2009: de Kruijf Petra; van Heteren Jane; Lim Herman D; Conti Paolo G M; van der Lee Miranda M C; Bosch Leontien; Ho Koc-Kan; Auld Douglas; Ohlmeyer Michael; Smit Martin J; Wijkmans Jac C H M; Zaman Guido J R; Smit Martine J; Leurs Rob
Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor.
The Journal of pharmacology and experimental therapeutics 2009;329(2):783-90.
2009: Maussang David; Langemeijer Ellen; Fitzsimons Carlos P; Stigter-van Walsum Marijke; Dijkman Remco; Borg Martin K; Slinger Erik; Schreiber Andreas; Michel Detlef; Tensen Cornelis P; van Dongen Guus A M S; Leurs Rob; Smit Martine J
The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2.
Cancer research 2009;69(7):2861-9.
2009: Wijtmans Maikel; Verzijl Dennis; van Dam Cindy M E; Bosch Leontien; Smit Martine J; Leurs Rob; de Esch Iwan J P
Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.
Bioorganic & medicinal chemistry letters 2009;19(8):2252-7.
2009: Maussang David; Vischer Henry F; Schreiber Andreas; Michel Detlef; Smit Martine J
Pharmacological and biochemical characterization of human cytomegalovirus-encoded G protein-coupled receptors.
Methods in enzymology 2009;460():151-71.
2008: Vischer Henry F; Nijmeijer Saskia; Smit Martine J; Leurs Rob
Viral hijacking of human receptors through heterodimerization.
Biochemical and biophysical research communications 2008;377(1):93-7.
2008: van Koppen Chris J; Zaman Guido J R; Timmers C Marco; Kelder Jan; Mosselman Sietse; van de Lagemaat Ruud; Smit Martin J; Hanssen Rob G J M
A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(5):503-14.
2008: van Rijn Richard M; van Marle André; Chazot Paul L; Langemeijer Ellen; Qin Yongjun; Shenton Fiona C; Lim Herman D; Zuiderveld Obbe P; Sansuk Kamonchanok; Dy Michel; Smit Martine J; Tensen Cornelis P; Bakker Remko A; Leurs Rob
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.
The Biochemical journal 2008;414(1):121-31.
2008: Wijtmans Maikel; Verzijl Dennis; Leurs Rob; de Esch Iwan J P; Smit Martine J
Towards small-molecule CXCR3 ligands with clinical potential.
ChemMedChem 2008;3(6):861-72.
2008: Verzijl Dennis; Storelli Stefania; Scholten Danny J; Bosch Leontien; Reinhart Todd A; Streblow Daniel N; Tensen Cornelis P; Fitzsimons Carlos P; Zaman Guido J R; Pease James E; de Esch Iwan J P; Smit Martine J; Leurs Rob
Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors.
The Journal of pharmacology and experimental therapeutics 2008;325(2):544-55.
2008: Catusse Julie; Spinks Jenny; Mattick Claire; Dyer Angela; Laing Ken; Fitzsimons Carlos; Smit Martine J; Gompels Ursula A
Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
European journal of immunology 2008;38(3):763-77.
2008: Rosenkilde M M; Smit M J; Waldhoer M
Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors.
British journal of pharmacology 2008;153 Suppl 1():S154-66.
2007: Schoonen Willem G E J; Kloks Cathelijne P A M; Ploemen Jan-Peter H T M; Horbach G Jean; Smit Martin J; Zandberg Pieter; Mellema Jan-Remt; Zuylen Carol Thijssen-van; Tas Albert C; van Nesselrooij Joop H J; Vogels Jack T W E
Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):271-85.
2007: Schoonen Willem G E J; Kloks Cathelijne P A M; Ploemen Jan-Peter H T M; Smit Martin J; Zandberg Pieter; Horbach G Jean; Mellema Jan-Remt; Thijssen-Vanzuylen Carol; Tas Albert C; van Nesselrooij Joop H J; Vogels Jack T W E
Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):286-97.
2007: Storelli Stefania; Verzijl Dennis; Al-Badie Jawad; Elders Niels; Bosch Leontien; Timmerman Henk; Smit Martine J; De Esch Iwan J P; Leurs Rob
Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists.
Archiv der Pharmazie 2007;340(6):281-91.
2007: Hulsman Niels; Medema Jan Paul; Bos Carina; Jongejan Aldo; Leurs Rob; Smit Martine J; de Esch Iwan J P; Richel Dick; Wijtmans Maikel
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.
Journal of medicinal chemistry 2007;50(10):2424-31.
2007: Smit Martine J; Vischer Henry F; Bakker Remko A; Jongejan Aldo; Timmerman Henk; Pardo Leonardo; Leurs Rob
Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.
Annual review of pharmacology and toxicology 2007;47():53-87.
2006: Verzijl Dennis; Pardo Leonardo; van Dijk Marie; Gruijthuijsen Yvonne K; Jongejan Aldo; Timmerman Henk; Nicholas John; Schwarz Mario; Murphy Philip M; Leurs Rob; Smit Martine J
Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding.
The Journal of biological chemistry 2006;281(46):35327-35.
2006: Hulshof Janneke W; Vischer Henry F; Verheij Mark H P; Fratantoni Silvina A; Smit Martine J; de Esch Iwan J P; Leurs Rob
Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28.
Bioorganic & medicinal chemistry 2006;14(21):7213-30.
2006: Maussang David; Verzijl Dennis; van Walsum Marijke; Leurs Rob; Holl Jens; Pleskoff Olivier; Michel Detlef; van Dongen Guus A M S; Smit Martine J
Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13068-73.
2006: van Cleef Koen W R; Smit Martine J; Bruggeman Cathrien A; Vink Cornelis
Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006;35(3):343-8.
2006: Fitzsimons Carlos P; Gompels Ursula A; Verzijl Dennis; Vischer Henry F; Mattick Claire; Leurs Rob; Smit Martine J
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
Molecular pharmacology 2006;69(3):888-98.
2006: Vischer Henry F; Leurs Rob; Smit Martine J
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
Trends in pharmacological sciences 2006;27(1):56-63.
2006: Vischer H F; Hulshof J W; de Esch I J P; Smit M J; Leurs R
Virus-encoded G-protein-coupled receptors: constitutively active (dys)regulators of cell function and their potential as drug target.
Ernst Schering Foundation symposium proceedings 2006;(2):187-209.
2006: Vischer H F; Vink C; Smit M J
A viral conspiracy: hijacking the chemokine system through virally encoded pirated chemokine receptors.
Current topics in microbiology and immunology 2006;303():121-54.
2005: Hulshof Janneke W; Casarosa Paola; Menge Wiro M P B; Kuusisto Leena M S; van der Goot Henk; Smit Martine J; de Esch Iwan J P; Leurs Rob
Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28.
Journal of medicinal chemistry 2005;48(20):6461-71.
2005: Storelli Stefania; Verdijk Pauline; Verzijl Dennis; Timmerman Henk; van de Stolpe Andrea C; Tensen Cornelis P; Smit Martine J; De Esch Iwan J P; Leurs Rob
Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(11):2910-3.
2005: Casarosa Paola; Waldhoer Maria; LiWang Patricia J; Vischer Henry F; Kledal Thomas; Timmerman Henk; Schwartz Thue W; Smit Martine J; Leurs Rob
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor.
The Journal of biological chemistry 2005;280(5):3275-85.
2005: Beisser Patrick S; Verzijl Dennis; Gruijthuijsen Yvonne K; Beuken Erik; Smit Martine J; Leurs Rob; Bruggeman Cathrien A; Vink Cornelis
The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase.
Journal of virology 2005;79(1):441-9.
2004: Gruijthuijsen Yvonne K; Beuken Erik V H; Smit Martine J; Leurs Rob; Bruggeman Cathrien A; Vink Cornelis
Mutational analysis of the R33-encoded G protein-coupled receptor of rat cytomegalovirus: identification of amino acid residues critical for cellular localization and ligand-independent signalling.
The Journal of general virology 2004;85(Pt 4):897-909.
2004: Verzijl Dennis; Fitzsimons Carlos P; Van Dijk Marie; Stewart James P; Timmerman Henk; Smit Martine J; Leurs Rob
Differential activation of murine herpesvirus 68- and Kaposi's sarcoma-associated herpesvirus-encoded ORF74 G protein-coupled receptors by human and murine chemokines.
Journal of virology 2004;78(7):3343-51.
2004: Hensbergen Paul J; Verzijl Dennis; Balog Crina I A; Dijkman Remco; van der Schors Roel C; van der Raaij-Helmer Elizabeth M H; van der Plas Mariena J A; Leurs Rob; Deelder André M; Smit Martine J; Tensen Cornelis P
Furin is a chemokine-modifying enzyme: in vitro and in vivo processing of CXCL10 generates a C-terminally truncated chemokine retaining full activity.
The Journal of biological chemistry 2004;279(14):13402-11.
2004: Bakker Remko A; Casarosa Paola; Timmerman Henk; Smit Martine J; Leurs Rob
Constitutively active Gq/11-coupled receptors enable signaling by co-expressed G(i/o)-coupled receptors.
The Journal of biological chemistry 2004;279(7):5152-61.
2003: Biró E; Sturk-Maquelin K N; Vogel G M T; Meuleman D G; Smit M J; Hack C E; Sturk A; Nieuwland R
Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner.
Journal of thrombosis and haemostasis : JTH 2003;1(12):2561-8.
2003: Govoni Marinella; Bakker Remko A; van de Wetering Ineke; Smit Martine J; Menge Wiro M B P; Timmerman Henk; Elz Sigurd; Schunack Walter; Leurs Rob
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
Journal of medicinal chemistry 2003;46(26):5812-24.
2003: Casarosa Paola; Gruijthuijsen Yvonne K; Michel Detlef; Beisser Patrick S; Holl Jens; Fitzsimons Carlos P; Verzijl Dennis; Bruggeman Cathrien A; Mertens Thomas; Leurs Rob; Vink Cornelis; Smit Martine J
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
The Journal of biological chemistry 2003;278(50):50010-23.
2003: Vogel G M T; Meuleman D G; Van Dinther T G; Buijsman R; Princen A W M; Smit M J
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity.
Journal of thrombosis and haemostasis : JTH 2003;1(9):1945-54.
2003: Smit Martine J; Verdijk Pauline; van der Raaij-Helmer Elisabeth M H; Navis Marjon; Hensbergen Paul J; Leurs Rob; Tensen Cornelis P
CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Blood 2003;102(6):1959-65.
2003: Hashimoto Takeshi; Harusawa Shinya; Araki Lisa; Zuiderveld Obbe P; Smit Martine J; Imazu Tomonari; Takashima Seiichiroh; Yamamoto Yumiko; Sakamoto Yasuhiko; Kurihara Takushi; Leurs Rob; Bakker Remko A; Yamatodani Atsushi
A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine.
Journal of medicinal chemistry 2003;46(14):3162-5.
2003: Smit M J; Vink C; Verzijl D; Casarosa P; Bruggeman C A; Leurs R
Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development.
Current drug targets 2003;4(5):431-41.
2003: Waldhoer Maria; Casarosa Paola; Rosenkilde Mette M; Smit Martine J; Leurs Rob; Whistler Jennifer L; Schwartz Thue W
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis.
The Journal of biological chemistry 2003;278(21):19473-82.
2003: Casarosa Paola; Menge Wiro M; Minisini Rosalba; Otto Claas; van Heteren Jane; Jongejan Aldo; Timmerman Henk; Moepps Barbara; Kirchhoff Frank; Mertens Thomas; Smit Martine J; Leurs Rob
Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor.
The Journal of biological chemistry 2003;278(7):5172-8.
2002: Adang Anton E P; de Man Adrianus P A; Vogel Gerard M T; Grootenhuis Peter D J; Smit Martin J; Peters Co A M; Visser Arie; Rewinkel Jos B M; van Dinther Theo; Lucas Hans; Kelder Jan; van Aelst Sjoerd; Meuleman Dick G; van Boeckel Constant A A
Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.
Journal of medicinal chemistry 2002;45(20):4419-32.
2002: Santore Tara Ann; Chen Yibang; Smit Martine J; Iyengar Ravi
Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1671-6.
2002: Smit Martine J; Verzijl Dennis; Casarosa Paola; Navis Marjon; Timmerman Henk; Leurs Rob
Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G(i) and phospholipase C-dependent signaling pathways.
Journal of virology 2002;76(4):1744-52.
2002: Gruijthuijsen Yvonne K; Casarosa Paola; Kaptein Suzanne J F; Broers Jos L V; Leurs Rob; Bruggeman Cathrien A; Smit Martine J; Vink Cornelis
The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion.
Journal of virology 2002;76(3):1328-38.
2002: Smit Martine J; Bakker Remko A; Burstein Ethan S
G protein-coupled receptors and proliferative signaling.
Methods in enzymology 2002;343():430-47.
2002: Leurs Rob; Hoffmann Marcel; Alewijnse Astrid E; Smit Martine J; Timmerman Henk
Methods to determine the constitutive activity of histamine H2 receptors.
Methods in enzymology 2002;343():405-16.
2001: Vink C; Smit M J; Leurs R; Bruggeman C A
The role of cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines in manipulation of and evasion from the immune system.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2001;23(1-2):43-55.
2001: Bakker R A; Schoonus S B; Smit M J; Timmerman H; Leurs R
Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.
Molecular pharmacology 2001;60(5):1133-42.
2001: Drutel G; Peitsaro N; Karlstedt K; Wieland K; Smit M J; Timmerman H; Panula P; Leurs R
Identification of rat H3 receptor isoforms with different brain expression and signaling properties.
Molecular pharmacology 2001;59(1):1-8.
2001: Casarosa P; Bakker R A; Verzijl D; Navis M; Timmerman H; Leurs R; Smit M J
Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28.
The Journal of biological chemistry 2001;276(2):1133-7.
2001: Zandberg P; Peters JLM; Demacker P N; de Reeder E G; Smit M J; Meuleman D G
Comparison of the antiatherosclerotic effect of tibolone with that of estradiol and ethinyl estradiol in cholesterol-fed, ovariectomized rabbits.
Menopause (New York, N.Y.) 2001;8(2):96-105.
2000: Alewijnse A E; Timmerman H; Jacobs E H; Smit M J; Roovers E; Cotecchia S; Leurs R
The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.
Molecular pharmacology 2000;57(5):890-8.
2000: Smit M J; Timmerman H; Verzijl D; Leurs R
Viral-encoded G-protein coupled receptors: new targets for drug research?
Pharmaceutica acta Helvetiae 2000;74(2-3):299-304.
1999: Rewinkel J B; Lucas H; Smit M J; Noach A B; van Dinther T G; Rood A M; Jenneboer A J; van Boeckel C A
Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(19):2837-42.
1999: Wieland K; Laak A M; Smit M J; Kühne R; Timmerman H; Leurs R
Mutational analysis of the antagonist-binding site of the histamine H(1) receptor.
The Journal of biological chemistry 1999;274(42):29994-30000.
1998: Zandberg P; Peters J L; Demacker P N; Smit M J; de Reeder E G; Meuleman D G
Tibolone prevents atherosclerotic lesion formation in cholesterol-fed, ovariectomized rabbits.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(12):1844-54.
1998: Smit M J; Verzijl D; Iyengar R
Identity of adenylyl cyclase isoform determines the rate of cell cycle progression in NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):15084-9.
1998: Leurs R; Smit M J; Alewijnse A E; Timmerman H
Agonist-independent regulation of constitutively active G-protein-coupled receptors.
Trends in biochemical sciences 1998;23(11):418-22.
1998: Alewijnse A E; Smit M J; Hoffmann M; Verzijl D; Timmerman H; Leurs R
Constitutive activity and structural instability of the wild-type human H2 receptor.
Journal of neurochemistry 1998;71(2):799-807.
1998: Chen J; Bander J A; Santore T A; Chen Y; Ram P T; Smit M J; Iyengar R
Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2648-52.
1998: Smit M J; Timmerman H; Alewijnse A E; Leurs R
From histamine H2 receptor regulation to reclassification of H2 antagonists; inverse agonism as the basis for H2 receptor upregulation.
Receptors & channels 1998;5(2):99-102.
1997: Alewijnse A E; Smit M J; Rodriguez Pena M S; Verzijl D; Timmerman H; Leurs R
Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active G(S)-coupled receptors.
FEBS letters 1997;419(2-3):171-4.
1997: Chen Y; Harry A; Li J; Smit M J; Bai X; Magnusson R; Pieroni J P; Weng G; Iyengar R
Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):14100-4.
1996: Smit M J; Timmerman H; Blauw J; Beukers M W; Roovers E; Jacobs E H; Hoffmann M; Leurs R
The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation.
Journal of neurochemistry 1996;67(5):1791-800.
1996: Smit M J; Leurs R; Alewijnse A E; Blauw J; Van Nieuw Amerongen G P; Van De Vrede Y; Roovers E; Timmerman H
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6802-7.
1996: Smit M J; Timmerman H; Hijzelendoorn J C; Fukui H; Leurs R
Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells.
British journal of pharmacology 1996;117(6):1071-80.
1996: Smit M J; Roovers E; Timmerman H; van de Vrede Y; Alewijnse A E; Leurs R
Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists.
The Journal of biological chemistry 1996;271(13):7574-82.
1995: Leurs R; Smit M J; Meeder R; Ter Laak A M; Timmerman H
Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists.
Biochemical and biophysical research communications 1995;214(1):110-7.
1995: Smit M J; Timmerman H; Alewijnse A E; Punin M; van den Nieuwenhof I; Blauw J; van Minnen J; Leurs R
Visualization of agonist-induced internalization of histamine H2 receptors.
Biochemical and biophysical research communications 1995;214(3):1138-45.
1995: ter Laak A M; Timmerman H; Leurs R; Nederkoorn P H; Smit M J; Donné-Op den Kelder G M
Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.
Journal of computer-aided molecular design 1995;9(4):319-30.
1995: Leurs R; Smit M J; Timmerman H
Molecular pharmacological aspects of histamine receptors.
Pharmacology & therapeutics 1995;66(3):413-63.
1994: Smit M J; Leurs R; Shukrula S R; Bast A; Timmerman H
Rapid desensitization of the histamine H2 receptor on the human monocytic cell line U937.
European journal of pharmacology 1994;288(1):17-25.
1994: Leurs R; Smit M J; Menge W M; Timmerman H
Pharmacological characterization of the human histamine H2 receptor stably expressed in Chinese hamster ovary cells.
British journal of pharmacology 1994;112(3):847-54.
1994: Leurs R; Smit M J; Tensen C P; Ter Laak A M; Timmerman H
Site-directed mutagenesis of the histamine H1-receptor reveals a selective interaction of asparagine207 with subclasses of H1-receptor agonists.
Biochemical and biophysical research communications 1994;201(1):295-301.
1993: Smit M J; Leurs R; Bloemers S M; Tertoolen L G; Bast A; De Laat S W; Timmerman H
Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor.
European journal of pharmacology 1993;247(2):223-6.
1993: Bloemers S M; Leurs R; Smit M J; Verheule S; Tertoolen L G; Timmerman H; de Laat S W
Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors.
Biochemical and biophysical research communications 1993;191(1):118-25.
1992: Smit M J; Bloemers S M; Leurs R; Tertoolen L G; Bast A; de Laat S W; Timmerman H
Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways.
British journal of pharmacology 1992;107(2):448-55.
1991: Leurs R; Smit M J; Bast A; Timmerman H
Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy.
European journal of pharmacology 1991;196(3):319-22.
1991: Leurs R; Brozius M M; Smit M J; Bast A; Timmerman H
Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine.
British journal of pharmacology 1991;102(1):179-85.
1991: Leurs R; Smit M J; Brozius M M; Jansen W; Bast A; Timmerman H
Is protein kinase C involved in histamine H1-receptor desensitization?
Agents and actions. Supplements 1991;33():393-402.
1990: Leurs R; Smit M J; Bast A; Timmerman H
Different profiles of desensitization dynamics in guinea-pig jejunal longitudinal smooth muscle after stimulation with histamine and methacholine.
British journal of pharmacology 1990;101(4):881-8.

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