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Amos Smith

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
30
Hirschmann, Ralph
12
Sprengeler, Paul
11
Xian, Ming
9
Freeze, Scott
9
Horwitz, Susan B.
8
Sodroski, Joseph
7
LaMarche, Matthew
7
Madani, Navid
7
Hirose, Tomoyasu
6
Cho, Young Shin
6
Kim, Dae-Shik
6
Pettit, George
6
Adams, Christopher M.
5
Brouard, Ignacio
5
Sfouggatakis, Chris

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Publications

TOP 3
Pitt Jason; Roth William; Lacor Pascale; Smith Amos B; Blankenship Matthew; Velasco Pauline; De Felice Fernanda; Breslin Paul; Klein William L
Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.
Hirschmann Ralph F; Nicolaou K C; Angeles Angie R; Chen Jason S; Smith Amos B
The beta-D-glucose scaffold as a beta-turn mimetic.
Smith Amos B; Dong Shuzhi; Brenneman Jehrod B; Fox Richard J
Total synthesis of (+)-sorangicin A.

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All Publications

2009: Pitt Jason; Roth William; Lacor Pascale; Smith Amos B; Blankenship Matthew; Velasco Pauline; De Felice Fernanda; Breslin Paul; Klein William L
Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.
Toxicology and applied pharmacology 2009;240(2):189-97.
2009: Hirschmann Ralph F; Nicolaou K C; Angeles Angie R; Chen Jason S; Smith Amos B
The beta-D-glucose scaffold as a beta-turn mimetic.
Accounts of chemical research 2009;42(10):1511-20.
2009: Smith Amos B; Dong Shuzhi; Brenneman Jehrod B; Fox Richard J
Total synthesis of (+)-sorangicin A.
Journal of the American Chemical Society 2009;131(34):12109-11.
2009: Kassa Aemro; Madani Navid; Schön Arne; Haim Hillel; Finzi Andrés; Xiang Shi-Hua; Wang Liping; Princiotto Amy; Pancera Marie; Courter Joel; Smith Amos B; Freire Ernesto; Kwong Peter D; Sodroski Joseph
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.
Journal of virology 2009;83(17):8364-78.
2009: Smith Amos B; Liu Zhuqing; Hogan Anne-Marie L; Dalisay Doralyn S; Molinski Tadeusz F
Hemi-phorboxazole a: structure confirmation, analogue design and biological evaluation.
Organic letters 2009;11(16):3766-9.
2009: Crowe Alex; Huang Wenwei; Ballatore Carlo; Johnson Ronald L; Hogan Anne-Marie L; Huang Ruili; Wichterman Jennifer; McCoy Joshua; Huryn Donna; Auld Douglas S; Smith Amos B; Inglese James; Trojanowski John Q; Austin Christopher P; Brunden Kurt R; Lee Virginia M-Y
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.
Biochemistry 2009;48(32):7732-45.
2009: Li Wenkai; Sperry Jeffrey B; Crowe Alex; Trojanowski John Q; Smith Amos B; Lee Virginia M-Y
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.
Journal of neurochemistry 2009;110(4):1339-51.
2009: Kassa Aemro; Finzi Andrés; Pancera Marie; Courter Joel R; Smith Amos B; Sodroski Joseph
Identification of a human immunodeficiency virus type 1 envelope glycoprotein variant resistant to cold inactivation.
Journal of virology 2009;83(9):4476-88.
2009: Haim Hillel; Si Zhihai; Madani Navid; Wang Liping; Courter Joel R; Princiotto Amy; Kassa Aemro; DeGrace Marciella; McGee-Estrada Kathleen; Mefford Megan; Gabuzda Dana; Smith Amos B; Sodroski Joseph
Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.
PLoS pathogens 2009;5(4):e1000360.
2009: Devarie-Baez Nelmi O; Kim Won-Suk; Smith Amos B; Xian Ming
Multicomponent type II anion relay chemistry (ARC): one-pot syntheses of 2,3-disubstituted furans and thiophenes.
Organic letters 2009;11(8):1861-4.
2009: Smith Amos B; Bosanac Todd; Basu Kallol
Evolution of the total synthesis of (-)-okilactomycin exploiting a tandem oxy-cope rearrangement/oxidation, a Petasis-Ferrier union/rearrangement, and ring-closing metathesis.
Journal of the American Chemical Society 2009;131(6):2348-58.
2008: Ballatore Carlo; Zhang Bin; Trojanowski John Q; Lee Virginia M-Y; Smith Amos B
In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate.
Bioorganic & medicinal chemistry letters 2008;18(23):6119-21.
2008: Madani Navid; Schön Arne; Princiotto Amy M; Lalonde Judith M; Courter Joel R; Soeta Takahiro; Ng Danny; Wang Liping; Brower Evan T; Xiang Shi-Hua; Kwon Young Do; Huang Chih-Chin; Wyatt Richard; Kwong Peter D; Freire Ernesto; Smith Amos B; Sodroski Joseph
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.
Structure (London, England : 1993) 2008;16(11):1689-701.
2008: Beshore Douglas C; Smith Amos B
The lyconadins: enantioselective total syntheses of (+)-lyconadin A and (-)-lyconadin B.
Journal of the American Chemical Society 2008;130(41):13778-89.
2008: Smith Amos B; Liu Zhuqing
Total synthesis of (-)-aplaminal.
Organic letters 2008;10(19):4363-5.
2008: Smith Amos B; Tomioka Takashi; Risatti Christina A; Sperry Jeffrey B; Sfouggatakis Chris
Gram-scale synthesis of (+)-spongistatin 1: development of an improved, scalable synthesis of the F-ring subunit, fragment union, and final elaboration.
Organic letters 2008;10(19):4359-62.
2008: Beavers Mary Pat; Myers Michael C; Shah Parag P; Purvis Jeremy E; Diamond Scott L; Cooperman Barry S; Huryn Donna M; Smith Amos B
Molecular docking of cathepsin L inhibitors in the binding site of papain.
Journal of chemical information and modeling 2008;48(7):1464-72.
2008: Shah Parag P; Myers Michael C; Beavers Mary Pat; Purvis Jeremy E; Jing Huiyan; Grieser Heather J; Sharlow Elizabeth R; Napper Andrew D; Huryn Donna M; Cooperman Barry S; Smith Amos B; Diamond Scott L
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.
Molecular pharmacology 2008;74(1):34-41.
2008: Myers Michael C; Shah Parag P; Beavers Mary Pat; Napper Andrew D; Diamond Scott L; Smith Amos B; Huryn Donna M
Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.
Bioorganic & medicinal chemistry letters 2008;18(12):3646-51.
2008: Smith Amos B; Fox Richard J; Razler Thomas M
Evolution of the Petasis-Ferrier union/rearrangement tactic: construction of architecturally complex natural products possessing the ubiquitous cis-2,6-substituted tetrahydropyran structural element.
Accounts of chemical research 2008;41(5):675-87.
2008: Gopi Hosahudya; Umashankara M; Pirrone Vanessa; LaLonde Judith; Madani Navid; Tuzer Ferit; Baxter Sabine; Zentner Isaac; Cocklin Simon; Jawanda Navneet; Miller Shendra R; Schön Arne; Klein Jeffrey C; Freire Ernesto; Krebs Fred C; Smith Amos B; Sodroski Joseph; Chaiken Irwin
Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.
Journal of medicinal chemistry 2008;51(9):2638-47.
2008: Smith Amos B; Razler Thomas M; Ciavarri Jeffrey P; Hirose Tomoyasu; Ishikawa Tomoyasu; Meis Regina M
A second-generation total synthesis of (+)-phorboxazole A.
The Journal of organic chemistry 2008;73(4):1192-200.
2008: Smith Amos B; Duffey Matthew O; Basu Kallol; Walsh Shawn P; Suennemann Hans W; Frohn Michael
Total syntheses of the assigned structures of lituarines B and C.
Journal of the American Chemical Society 2008;130(2):422-3.
2008: Myers Michael C; Shah Parag P; Diamond Scott L; Huryn Donna M; Smith Amos B
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.
Bioorganic & medicinal chemistry letters 2008;18(1):210-4.
2008: Smith Amos B; Kim Won-Suk; Wuest William M
Ortho-TMS benzaldehyde: an effective linchpin for type II anion relay chemistry (ARC).
Angewandte Chemie (International ed. in English) 2008;47(37):7082-6.
2007: Smith Amos B; Basu Kallol; Bosanac Todd
Total synthesis of (-)-okilactomycin.
Journal of the American Chemical Society 2007;129(48):14872-4.
2007: Xie Hui; Ng Danny; Savinov Sergey N; Dey Barna; Kwong Peter D; Wyatt Richard; Smith Amos B; Hendrickson Wayne A
Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.
Journal of medicinal chemistry 2007;50(20):4898-908.
2007: Shaw Simon J; Menzella Hugo G; Myles David C; Xian Ming; Smith Amos B
Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region.
Organic & biomolecular chemistry 2007;5(17):2753-5.
2007: Smith Amos B; Lee Dongjoo
Total synthesis of (+)-tedanolide.
Journal of the American Chemical Society 2007;129(35):10957-62.
2007: Myers Michael C; Napper Andrew D; Motlekar Nuzhat; Shah Parag P; Chiu Chun-Hao; Beavers Mary Pat; Diamond Scott L; Huryn Donna M; Smith Amos B
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.
Bioorganic & medicinal chemistry letters 2007;17(17):4761-6.
2007: Smith Amos B; Sperry Jeffrey B; Han Qiang
Syntheses of (-)-oleocanthal, a natural NSAID found in extra virgin olive oil, the (-)-deacetoxy-oleuropein aglycone, and related analogues.
The Journal of organic chemistry 2007;72(18):6891-900.
2007: Smith Amos B; Kim Dae-Shik
The spirastrellolides: construction of the southern C(1)-C(25) fragment exploiting anion relay chemistry.
Organic letters 2007;9(17):3311-4.
2007: Smith Amos B; Kim Dae-Shik; Xian Ming
Anion relay chemistry extended. Synthesis of a gorgonian sesquiterpene.
Organic letters 2007;9(17):3307-9.
2007: Ballatore Carlo; Hyde Edward; Deiches Robert F; Lee Virginia M-Y; Trojanowski John Q; Huryn Donna; Smith Amos B
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies.
Bioorganic & medicinal chemistry letters 2007;17(13):3642-6.
2007: Smith Amos B; Kürti László; Davulcu Akin H; Cho Young Shin; Ohmoto Kazuyuki
Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B.
The Journal of organic chemistry 2007;72(13):4611-20.
2007: Smith Amos B; Davulcu Akin H; Cho Young Shin; Ohmoto Kazuyuki; Kürti László; Ishiyama Haruaki
Indole diterpene synthetic studies. Total synthesis of (+)-nodulisporic acid F and construction of the heptacyclic cores of (+)-nodulisporic acids A and B and (-)-nodulisporic acid D.
The Journal of organic chemistry 2007;72(13):4596-610.
2007: Beshore Douglas C; Smith Amos B
Total syntheses of (+)-lyconadin A and (-)-lyconadin B.
Journal of the American Chemical Society 2007;129(14):4148-9.
2007: Bagchi Sayan; Kim Yung Sam; Charnley Adam K; Smith Amos B; Hochstrasser Robin M
Two-dimensional infrared investigation of N-acetyl tryptophan methyl amide in solution.
The journal of physical chemistry. B 2007;111(11):3010-8.
2006: Xia Shujun; Kenesky Craig S; Rucker Paul V; Smith Amos B; Orr George A; Horwitz Susan Band
A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.
Biochemistry 2006;45(39):11762-75.
2006: Mowery Brendan P; Prasad Vidya; Kenesky Craig S; Angeles Angie R; Taylor Laurie L; Feng Jin-Jye; Chen Wen-Long; Lin Atsui; Cheng Fong-Chi; Smith Amos B; Hirschmann Ralph
Catechol: A minimal scaffold for non-peptide peptidomimetics of the i + 1 and i + 2 positions of the beta-turn of somatostatin.
Organic letters 2006;8(20):4397-400.
2006: Smith Amos B; Xian Ming; Kim Won-Suk; Kim Dae-Shik
The [1,5]-Brook rearrangement: an initial application in anion relay chemistry.
Journal of the American Chemical Society 2006;128(38):12368-9.
2006: Schön Arne; Madani Navid; Klein Jeffrey C; Hubicki Amy; Ng Danny; Yang Xinzhen; Smith Amos B; Sodroski Joseph; Freire Ernesto
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.
Biochemistry 2006;45(36):10973-80.
2006: Smith Amos B; Simov Vladimir
Total synthesis of the marine natural product (-)-clavosolide A. A showcase for the Petasis-Ferrier union/rearrangement tactic.
Organic letters 2006;8(15):3315-8.
2006: Smith Amos B; Kürti Laszló; Davulcu Akin H
A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B.
Organic letters 2006;8(10):2167-70.
2006: Foister Shane; Taylor Laurie L; Feng Jin-Jye; Chen Wen-Long; Lin Atsui; Cheng Fong-Chi; Smith Amos B; Hirschmann Ralph
Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptor.
Organic letters 2006;8(9):1799-802.
2006: Smith Amos B; Mesaros Eugen F; Meyer Emmanuel A
Evolution of a total synthesis of (-)-kendomycin exploiting a Petasis-Ferrier rearrangement/ring-closing olefin metathesis strategy.
Journal of the American Chemical Society 2006;128(15):5292-9.
2006: Smith Amos B; Davulcu Akin H; Kürti Laszló
Indole diterpenoid synthetic studies. Construction of the heptacyclic core of (-)-nodulisporic acid D.
Organic letters 2006;8(8):1669-72.
2006: Smith Amos B; Davulcu Akin H; Kürti Laszló
Indole diterpenoid synthetic studies. The total synthesis of (+)-nodulisporic acid F.
Organic letters 2006;8(8):1665-8.
2006: Smith Amos B; Kim Dae-Shik
A general, convergent strategy for the construction of indolizidine alkaloids: total syntheses of (-)-indolizidine 223AB and alkaloid (-)-205B.
The Journal of organic chemistry 2006;71(7):2547-57.
2006: Smith Amos B; Razler Thomas M; Meis Regina M; Pettit George R
Design and synthesis of a potent phorboxazole C(11-15) acetal analogue.
Organic letters 2006;8(4):797-9.
2006: Smith Amos B; Charnley Adam K; Harada Hironori; Beiger Jason J; Cantin Louis-David; Kenesky Craig S; Hirschmann Ralph; Munshi Sanjeev; Olsen David B; Stahlhut Mark W; Schleif William A; Kuo Lawrence C
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.
Bioorganic & medicinal chemistry letters 2006;16(4):859-63.
2006: Huang Gloria S; Lopez-Barcons Lluis; Freeze B Scott; Smith Amos B; Goldberg Gary L; Horwitz Susan Band; McDaid Hayley M
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):298-304.
2006: Smith Amos B; Xian Ming
Anion relay chemistry: an effective tactic for diversity oriented synthesis.
Journal of the American Chemical Society 2006;128(1):66-7.
2006: Smith Amos B
Editorial 2006: exciting and challenging times for organic letters.
Organic letters 2006;8(1):1-2.
2006: Sun Chengzao; Aspland Simon E; Ballatore Carlo; Castillo Rosario; Smith Amos B; Castellino Angelo J
The design, synthesis, and evaluation of two universal doxorubicin-linkers: preparation of conjugates that retain topoisomerase II activity.
Bioorganic & medicinal chemistry letters 2006;16(1):104-7.
2005: Fuertes Michael J; Kaur Jaskiran; Deb Prasant; Cooperman Barry S; Smith Amos B
Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase.
Bioorganic & medicinal chemistry letters 2005;15(23):5146-9.
2005: Smith Amos B; Xian Ming
Design, synthesis, and biological evaluation of simplified analogues of (+)-discodermolide. Additional insights on the importance of the diene, the C7 hydroxyl, and the lactone.
Organic letters 2005;7(23):5229-32.
2005: Smith Amos B; Rucker Paul V; Brouard Ignacio; Freeze B Scott; Xia Shujun; Horwitz Susan Band
Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes.
Organic letters 2005;7(23):5199-202.
2005: Smith Amos B; Han Qiang; Breslin Paul A S; Beauchamp Gary K
Synthesis and assignment of absolute configuration of (-)-oleocanthal: a potent, naturally occurring non-steroidal anti-inflammatory and anti-oxidant agent derived from extra virgin olive oils.
Organic letters 2005;7(22):5075-8.
2005: Smith Amos B; Xian Ming; Liu Fenghua
Design, total synthesis, and evaluation of C13-C14 cyclopropane analogues of (+)-discodermolide.
Organic letters 2005;7(21):4613-6.
2005: Smith Amos B; Razler Thomas M; Pettit George R; Chapuis Jean-Charles
(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues.
Organic letters 2005;7(20):4403-6.
2005: Smith Amos B; Razler Thomas M; Ciavarri Jeffrey P; Hirose Tomoyasu; Ishikawa Tomoyasu
(+)-Phorboxazole A synthetic studies. A highly convergent, second generation total synthesis of (+)-phorboxazole A.
Organic letters 2005;7(20):4399-402.
2005: Mani Sridhar; Huang Haiyan; Sundarababu Sumathy; Liu Wenjing; Kalpana Ganjam; Smith Amos B; Horwitz Susan B
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6359-69.
2005: Beauchamp Gary K; Keast Russell S J; Morel Diane; Lin Jianming; Pika Jana; Han Qiang; Lee Chi-Ho; Smith Amos B; Breslin Paul A S
Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.
Nature 2005;437(7055):45-6.
2005: Cho Cheon-Gyu; Kim Won-Suk; Smith Amos B
A scalable route to trisubstituted (E)-vinyl bromides.
Organic letters 2005;7(16):3569-72.
2005: Smith Amos B; Freeze B Scott; LaMarche Matthew J; Sager Jason; Kinzler Kenneth W; Vogelstein Bert
Discodermolide analogues as the chemical component of combination bacteriolytic therapy.
Bioorganic & medicinal chemistry letters 2005;15(15):3623-6.
2005: Smith Amos B; Kim Dae-Shik
Total synthesis of the neotropical poison-frog alkaloid (-)-205B.
Organic letters 2005;7(15):3247-50.
2005: Smith Amos B; Fox Richard J; Vanecko John A
(+)-Sorangicin A synthetic studies. Construction of the C(1-15) and C(16-29) subtargets.
Organic letters 2005;7(14):3099-102.
2005: Neelamkavil Santhosh; Arison Byron; Birzin Elizabeth; Feng Jin-Jye; Chen Kuo-Hsin; Lin Atsui; Cheng Fong-Chi; Taylor Laurie; Thornton Edward R; Smith Amos B; Hirschmann Ralph
Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.
Journal of medicinal chemistry 2005;48(12):4025-30.
2005: Trojanowski John Q; Smith Amos B; Huryn Donna; Lee Virginia M-Y
Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.
Expert opinion on pharmacotherapy 2005;6(5):683-6.
2005: Smith Amos B; Mesaros Eugen F; Meyer Emmanuel A
Total synthesis of (-)-kendomycin exploiting a Petasis-Ferrier rearrangement/ring-closing olefin metathesis synthetic strategy.
Journal of the American Chemical Society 2005;127(19):6948-9.
2005: Shaw Simon J; Sundermann Kurt F; Burlingame Mark A; Myles David C; Freeze B Scott; Xian Ming; Brouard Ignacio; Smith Amos B
Toward understanding how the lactone moiety of discodermolide affects activity.
Journal of the American Chemical Society 2005;127(18):6532-3.
2005: Ballatore Carlo; Aspland Simon E; Castillo Rosario; Desharnais Joel; Eustaquio Trisha; Sun Chengzao; Castellino Angelo J; Smith Amos B
A facile route to paclitaxel C-10 carbamates.
Bioorganic & medicinal chemistry letters 2005;15(10):2477-80.
2005: Smith Amos B; Freeze B Scott; Xian Ming; Hirose Tomoyasu
Total synthesis of (+)-discodermolide: a highly convergent fourth-generation approach.
Organic letters 2005;7(9):1825-8.
2005: Angeles Angie R; Neagu Irina; Birzin Elizabeth T; Thornton Edward R; Smith Amos B; Hirschmann Ralph
Synthesis and binding affinities of novel SRIF-mimicking beta-D-glucosides satisfying the requirement for a pi-cloud at C1.
Organic letters 2005;7(6):1121-4.
2005: Klein Laura E; Freeze B Scott; Smith Amos B; Horwitz Susan Band
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence.
Cell cycle (Georgetown, Tex.) 2005;4(3):501-7.
2005: Smith Amos B; Charnley Adam K; Mesaros Eugen F; Kikuchi Osamu; Wang Wenyong; Benowitz Andrew; Chu Chi-Lien; Feng Jin-Jye; Chen Kuo-Hsin; Lin Atsui; Cheng Fong-Chi; Taylor Laurie; Hirschmann Ralph
Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics.
Organic letters 2005;7(3):399-402.
2005: Neelamkavil S; Mowery B P; Thornton E R; Smith A B; Hirschmann R
A practical synthesis of Nalpha-Fmoc-L-pyrazinylalanine via Schöllkopf's chiral auxiliary.
The journal of peptide research : official journal of the American Peptide Society 2005;65(1):139-42.
2005: Smith Amos B; Freeze B Scott; Lamarche Matthew J; Hirose Tomoyasu; Brouard Ignacio; Xian Ming; Sundermann Kurt F; Shaw Simon J; Burlingame Mark A; Horwitz Susan Band; Myles David C
Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.
Organic letters 2005;7(2):315-8.
2005: Smith Amos B; Freeze B Scott; Lamarche Matthew J; Hirose Tomoyasu; Brouard Ignacio; Rucker Paul V; Xian Ming; Sundermann Kurt F; Shaw Simon J; Burlingame Mark A; Horwitz Susan Band; Myles David C
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.
Organic letters 2005;7(2):311-4.
2005: Smith Amos B; Walsh Shawn P; Frohn Michael; Duffey Matthew O
Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: development of a unified approach for the C(1-19) segments of lituarines A-C.
Organic letters 2005;7(1):139-42.
2004: Smith Amos B; Sfouggatakis Chris; Gotchev Dimitar B; Shirakami Shohei; Bauer David; Zhu Wenyu; Doughty Victoria A
Spongistatin synthetic studies. evolution of a scalable synthesis for the EF fragment of (+)-Spongistatin 1 exploiting a Petasis-Ferrier union/rearrangement tactic.
Organic letters 2004;6(20):3637-40.
2004: Smith Amos B; Adams Christopher M; Barbosa Stephanie A Lodise; Degnan Andrew P
A unified approach to the tedanolides: total synthesis of (+)-13-deoxytedanolide.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12042-7.
2004: Smith Amos B; Adams Christopher M
Evolution of dithiane-based strategies for the construction of architecturally complex natural products.
Accounts of chemical research 2004;37(6):365-77.
2004: Burlingame Mark A; Shaw Simon J; Sundermann Kurt F; Zhang Dan; Petryka Joseph; Mendoza Esteban; Liu Fenghua; Myles David C; LaMarche Matthew J; Hirose Tomoyasu; Scott Freeze B; Smith Amos B
Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.
Bioorganic & medicinal chemistry letters 2004;14(9):2335-8.
2004: Smith Amos B; Kim Dae-Shik
Multicomponent linchpin coupling of silyl dithianes employing an N-Ts aziridine as the second electrophile: synthesis of (-)-indolizidine 223AB.
Organic letters 2004;6(9):1493-5.
2004: Smith Amos B; Fox Richard J
Construction of a C(30-38) dioxabicyclo[3.2.1]octane subtarget for (+)-sorangicin A, exploiting a regio- and stereocontrolled acid-catalyzed epoxide ring opening.
Organic letters 2004;6(9):1477-80.
2004: Si Zhihai; Madani Navid; Cox Jason M; Chruma Jason J; Klein Jeffrey C; Schön Arne; Phan Ngoc; Wang Liping; Biorn Alyssa C; Cocklin Simon; Chaiken Irwin; Freire Ernesto; Smith Amos B; Sodroski Joseph G
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):5036-41.
2004: Smith Amos B; Chruma Jason J; Han Qiang; Barbosa Joseph
Complestatin synthetic studies; the effect of the amino acid configuration on peptide backbone conformation in the common western BCD macrocycle.
Bioorganic & medicinal chemistry letters 2004;14(7):1697-702.
2004: Madani Navid; Perdigoto Ana Luisa; Srinivasan Kumar; Cox Jason M; Chruma Jason J; LaLonde Judith; Head Martha; Smith Amos B; Sodroski Joseph G
Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.
Journal of virology 2004;78(7):3742-52.
2004: Dang Long H; Bettegowda Chetan; Agrawal Nishant; Cheong Ian; Huso David; Frost Philip; Loganzo Frank; Greenberger Lee; Barkoczy Jozsef; Pettit George R; Smith Amos B; Gurulingappa Hallur; Khan Saeed; Parmigiani Giovanni; Kinzler Kenneth W; Zhou Shibin; Vogelstein Bert
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents.
Cancer biology & therapy 2004;3(3):326-37.
2004: Abrous Leïla; Jokiel Patrick A; Friedrich Sarah R; Hynes John; Smith Amos B; Hirschmann Ralph
Novel chimeric scaffolds to extend the exploration of receptor space: hybrid beta-D-glucose-benzoheterodiazepine structures for broad screening. Effect of amide alkylation on the course of cyclization reactions.
The Journal of organic chemistry 2004;69(2):280-302.
2003: Smith Amos B; Pitram Suresh M; Boldi Armen M; Gaunt Matthew J; Sfouggatakis Chris; Moser William H
Multicomponent linchpin couplings. Reaction of dithiane anions with terminal epoxides, epichlorohydrin, and vinyl epoxides: efficient, rapid, and stereocontrolled assembly of advanced fragments for complex molecule synthesis.
Journal of the American Chemical Society 2003;125(47):14435-45.
2003: Smith Amos B; Freeze B Scott; Brouard Ignacio; Hirose Tomoyasu
A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach.
Organic letters 2003;5(23):4405-8.
2003: Smith Amos B; Pitram Suresh M; Fuertes Michael J
(+)-Rimocidin synthetic studies. Construction of an advanced C(1-18) polyol fragment.
Organic letters 2003;5(15):2751-4.
2003: Smith Amos B; Kanoh Naoki; Ishiyama Haruaki; Minakawa Noriaki; Rainier Jon D; Hartz Richard A; Cho Young Shin; Cui Haifeng; Moser William H
Tremorgenic indole alkaloids. The total synthesis of (-)-penitrem D.
Journal of the American Chemical Society 2003;125(27):8228-37.
2003: Prasad Vidya; Birzin Elizabeth T; McVaugh Cheryl T; Van Rijn Rachel D; Rohrer Susan P; Chicchi Gary; Underwood Dennis J; Thornton Edward R; Smith Amos B; Hirschmann Ralph
Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents.
Journal of medicinal chemistry 2003;46(10):1858-69.
2003: Smith Amos B; Cantin Louis-David; Pasternak Alexander; Guise-Zawacki Lisa; Yao Wenquin; Charnley Adam K; Barbosa Joseph; Sprengeler Paul A; Hirschmann Ralph; Munshi Sanjeev; Olsen David B; Schleif William A; Kuo Lawrence C
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.
Journal of medicinal chemistry 2003;46(10):1831-44.
2003: Savinov Sergey N; Hirschmann Ralph; Benkovic Stephen J; Smith Amos B
Investigation of an antibody-ligase. Evidence for strain-induced catalysis.
Bioorganic & medicinal chemistry letters 2003;13(7):1321-4.
2003: Smith Amos B; Zhu Wenyu; Shirakami Shohei; Sfouggatakis Chris; Doughty Victoria A; Bennett Clay S; Sakamoto Yasuharu
Total synthesis of (+)-spongistatin 1. An effective second-generation construction of an advanced EF Wittig salt, fragment union, and final elaboration.
Organic letters 2003;5(5):761-4.
2003: Smith Amos B; Cui Haifeng
Total synthesis of (-)-21-isopentenylpaxilline.
Organic letters 2003;5(4):587-90.
2003: Smith Amos B; Adams Christopher M; Lodise Barbosa Stephanie A; Degnan Andrew P
Total synthesis of (+)-13-deoxytedanolide.
Journal of the American Chemical Society 2003;125(2):350-1.
2002: Smith Amos B; Pitram Suresh M; Gaunt Matthew J; Kozmin Sergey A
Dithiane additions to vinyl epoxides: steric control over the SN2 and SN2' manifolds.
Journal of the American Chemical Society 2002;124(49):14516-7.
2002: Smith Amos B; Lee Dongjoo; Adams Christopher M; Kozlowski Marisa C
SmI(2)-promoted oxidation of aldehydes in the presence of electron-rich heteroatoms.
Organic letters 2002;4(25):4539-41.
2002: Smith Amos B; Savinov Sergey N; Manjappara Uma V; Chaiken Irwin M
Peptide-small molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study.
Organic letters 2002;4(23):4041-4.
2002: Smith Amos B; Safonov Igor G; Corbett R Michael
Total syntheses of (+)-zampanolide and (+)-dactylolide exploiting a unified strategy.
Journal of the American Chemical Society 2002;124(37):11102-13.
2002: Smith Amos B; Corbett R Michael; Pettit George R; Chapuis Jean Charles; Schmidt Jean M; Hamel Ernest; Jung M Katherine
Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue.
Bioorganic & medicinal chemistry letters 2002;12(15):2039-42.
2002: Murphy Paul V; O'Brien Julie L; Gorey-Feret Lorraine J; Smith Amos B
Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds.
Bioorganic & medicinal chemistry letters 2002;12(13):1763-6.
2002: Smith Amos B; Doughty Victoria A; Sfouggatakis Chris; Bennett Clay S; Koyanagi Jyunichi; Takeuchi Makoto
Spongistatin synthetic studies. An efficient, second-generation construction of an advanced ABCD intermediate.
Organic letters 2002;4(5):783-6.
2002: Smith Amos B; Safonov Igor G
Total synthesis of (+)-dactylolide.
Organic letters 2002;4(4):635-7.
2001: Smith A B; Cho Y S; Zawacki L E; Hirschmann R; Pettit G R
First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.
Organic letters 2001;3(25):4063-6.
2001: Smith A B; Safonov I G; Corbett R M
Total synthesis of (+)-zampanolide.
Journal of the American Chemical Society 2001;123(49):12426-7.
2001: Smith A B; Frohn M
Lituarine synthetic studies. An efficient, stereocontrolled construction of the common c(7-19) tricyclic spiroketal fragment.
Organic letters 2001;3(24):3979-82.
2001: Smith A B; Cho Y S; Ishiyama H
Nodulisporic acid A synthetic studies. 2. Construction of an eastern hemisphere subtarget.
Organic letters 2001;3(24):3971-4.
2001: Smith A B; Ishiyama H; Cho Y S; Ohmoto K
Nodulisporic acid A synthetic studies. 1. Overall strategy and construction of a western hemisphere subtarget.
Organic letters 2001;3(24):3967-70.
2001: Smith A B; Minbiole K P; Verhoest P R; Schelhaas M
Total synthesis of (+)-phorboxazole A exploiting the Petasis-Ferrier rearrangement.
Journal of the American Chemical Society 2001;123(44):10942-53.
2001: Martello L A; LaMarche M J; He L; Beauchamp T J; Smith A B; Horwitz S B
The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.
Chemistry & biology 2001;8(9):843-55.
2001: Murphy P V; O'Brien J L; Smith A B
Stereospecific synthesis of beta-D-allopyranosides by dihydroxylation of beta-D-erythro-2,3-dideoxyhex-2-enopyranosides.
Carbohydrate research 2001;334(4):327-35.
2001: Smith A B; Adams C M; Kozmin S A; Paone D V
Total synthesis of (-)-cylindrocyclophanes A and F exploiting the reversible nature of the olefin cross metathesis reaction.
Journal of the American Chemical Society 2001;123(25):5925-37.
2001: Smith A B; Verhoest P R; Minbiole K P; Schelhaas M
Total synthesis of (+)-phorboxazole A.
Journal of the American Chemical Society 2001;123(20):4834-6.
2001: Smith A B; Brandt B M
Total synthesis of (-)-callystatin A.
Organic letters 2001;3(11):1685-8.
2001: Abrous L; Hynes J; Friedrich S R; Smith A B; Hirschmann R
Design and synthesis of novel scaffolds for drug discovery: hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one, the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines.
Organic letters 2001;3(7):1089-92.
2001: Smith A B; LaMarche M J; Falcone-Hindley M
Solution structure of (+)-discodermolide.
Organic letters 2001;3(5):695-8.
2001: Smith A B; Adams C M; Kozmin S A
On the reversible nature of the olefin cross metathesis reaction.
Journal of the American Chemical Society 2001;123(5):990-1.
2000: Hirschmann R; Ducry L; Smith A B
Development of an efficient, regio- and stereoselective route to libraries based on the beta-D-glucose scaffold.
The Journal of organic chemistry 2000;65(24):8307-16.
2000: Smith A B; Ducry L; Corbett R M; Hirschmann R
Intramolecular hydrogen-bond participation in phosphonylammonium salt formation.
Organic letters 2000;2(24):3887-90.
2000: Smith A B; Nittoli T; Sprengeler P A; Duan J J; Liu R Q; Hirschmann R F
Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor.
Organic letters 2000;2(24):3809-12.
2000: Liu J; Underwood D J; Cascieri M A; Rohrer S P; Cantin L D; Chicchi G; Smith A B; Hirschmann R
Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry.
Journal of medicinal chemistry 2000;43(21):3827-31.
2000: Smith A B; Liu H; Okumura H; Favor D A; Hirschmann R
Synthesis of polypyrrolinones on solid support.
Organic letters 2000;2(14):2041-4.
2000: Smith A B; Liu H; Hirschmann R
A second-generation synthesis of polypyrrolinone nonpeptidomimetics: prelude to the synthesis of polypyrrolinones on solid support.
Organic letters 2000;2(14):2037-40.
2000: Smith A B; Wan Z
Total synthesis of the ansamycin antibiotic (+)-thiazinotrienomycin E.
The Journal of organic chemistry 2000;65(12):3738-53.
2000: Martello L A; McDaid H M; Regl D L; Yang C P; Meng D; Pettus T R; Kaufman M D; Arimoto H; Danishefsky S J; Smith A B; Horwitz S B
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1978-87.
1999: Smith A B; Pitram S M
Multicomponent linchpin couplings of silyl dithianes: synthesis of the Schreiber C(16-28) trisacetonide subtarget for mycoticins A and B.
Organic letters 1999;1(12):2001-4.
1999: Smith A B; Kaufman M D; Beauchamp T J; LaMarche M J; Arimoto H
Gram-scale synthesis of (+)-discodermolide.
Organic letters 1999;1(11):1823-6.
1999: Smith A B; Wan Z
Total synthesis of (+)-thiazinotrienomycin E.
Organic letters 1999;1(9):1491-4.
1999: Smith A B; Kanoh N; Minakawa N; Rainier J D; Blase F R; Hartz R A
Tremorgenic indole alkaloids. Studies directed toward the assembly of the A, F, and I rings of penitrem D: observation of an unexpected stereochemical outcome.
Organic letters 1999;1(8):1263-6.
1999: Smith A B; Lodise S A
Synthesis of tedanolide and 13-deoxytedanolide. Assembly of a common C(1)-C(11) subtarget.
Organic letters 1999;1(8):1249-52.
1999: Liehr S; Barbosa J; Smith A B; Cooperman B S
Synthesis and biological activity of cyclic peptide inhibitors of ribonucleotide reductase.
Organic letters 1999;1(8):1201-4.
1999: Smith A B; Minbiole K P; Verhoest P R; Beauchamp T J
Phorboxazole synthetic studies. 2. Construction of a C(20-28) subtarget, a further extension of the Petasis-Ferrier rearrangement.
Organic letters 1999;1(6):913-6.
1999: Smith A B; Verhoest P R; Minbiole K P; Lim J J
Phorboxazole synthetic studies. 1. Construction of a C(3-19) subtarget exploiting an extension of the Petasis-Ferrier rearrangement.
Organic letters 1999;1(6):909-12.
1999: Smith A B; Favor D A; Sprengeler P A; Guzman M C; Carroll P J; Furst G T; Hirschmann R
Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold.
Bioorganic & medicinal chemistry 1999;7(1):9-22.
1998: Smith A B; Sasho S; Barwis B A; Sprengeler P; Barbosa J; Hirschmann R; Cooperman B S
Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase.
Bioorganic & medicinal chemistry letters 1998;8(22):3133-6.
1998: Hirschmann R; Hynes J; Cichy-Knight M A; van Rijn R D; Sprengeler P A; Spoors P G; Shakespeare W C; Pietranico-Cole S; Barbosa J; Liu J; Yao W; Rohrer S; Smith A B
Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.
Journal of medicinal chemistry 1998;41(9):1382-91.
1998: Smith A B; Lin Q; Pettit G R; Chapuis J C; Schmidt J M
Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.
Bioorganic & medicinal chemistry letters 1998;8(6):567-8.
1997: Smith A B; Hirschmann R; Pasternak A; Yao W; Sprengeler P A; Holloway M K; Kuo L C; Chen Z; Darke P L; Schleif W A
An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.
Journal of medicinal chemistry 1997;40(16):2440-4.
1996: Smith A B; Knight S D; Sprengeler P A; Hirschmann R
The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold.
Bioorganic & medicinal chemistry 1996;4(7):1021-34.
1996: Hirschmann R; Yao W; Cascieri M A; Strader C D; Maechler L; Cichy-Knight M A; Hynes J; van Rijn R D; Sprengeler P A; Smith A B
Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.
Journal of medicinal chemistry 1996;39(13):2441-8.
1995: Smith A B; Akaishi R; Jones D R; Keenan T P; Guzman M C; Holcomb R C; Sprengeler P A; Wood J L; Hirschmann R; Holloway M K
Design and synthesis of nonpeptide peptidomimetic inhibitors of renin.
Biopolymers 1995;37(1):29-53.
1994: Hirschmann R; Smith A B; Taylor C M; Benkovic P A; Taylor S D; Yager K M; Sprengeler P A; Benkovic S J
Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids.
Science (New York, N.Y.) 1994;265(5169):234-7.
1994: Smith A B; Hirschmann R; Pasternak A; Akaishi R; Guzman M C; Jones D R; Keenan T P; Sprengeler P A; Darke P L; Emini E A
Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.
Journal of medicinal chemistry 1994;37(2):215-8.
1993: Lender A; Yao W; Sprengeler P A; Spanevello R A; Furst G T; Hirschmann R; Smith A B
Design and synthesis of sulfur-free cyclic hexapeptides which contain the RGD sequence and bind to the fibrinogen GP IIb/IIIa receptor. A conformation-based correlation between propensity for imide formation and receptor affinity.
International journal of peptide and protein research 1993;42(6):509-17.

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