Bernard Rees Smith

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Furmaniak Jadwiga; Sanders Jane; Smith Bernard Rees
Thyrotropin receptor structure--in the crystal new horizons shine.
Smith Bernard Rees; Furmaniak Jadwiga; Sanders Jane
TSH receptor blocking antibodies.
Sanders Jane; Evans Michele; Betterle Corrado; Sanders Paul; Bhardwaja Anshu; Young Stuart; Roberts Emma; Wilmot Jane; Richards Tonya; Kiddie Angela; Small Kasemsri; Platt Hayley; Summerhayes Sara; Harris Rebecca; Reeve Magnus; Coco Graziella; Zanchetta Renato; Chen Shu; Furmaniak Jadwiga; Smith Bernard Rees
A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity.

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2009: Furmaniak Jadwiga; Sanders Jane; Smith Bernard Rees
Thyrotropin receptor structure--in the crystal new horizons shine.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2009;15(1):56-60.
2008: Smith Bernard Rees; Furmaniak Jadwiga; Sanders Jane
TSH receptor blocking antibodies.
Thyroid : official journal of the American Thyroid Association 2008;18(11):1239.
2008: Sanders Jane; Evans Michele; Betterle Corrado; Sanders Paul; Bhardwaja Anshu; Young Stuart; Roberts Emma; Wilmot Jane; Richards Tonya; Kiddie Angela; Small Kasemsri; Platt Hayley; Summerhayes Sara; Harris Rebecca; Reeve Magnus; Coco Graziella; Zanchetta Renato; Chen Shu; Furmaniak Jadwiga; Smith Bernard Rees
A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity.
Thyroid : official journal of the American Thyroid Association 2008;18(7):735-46.
2008: Coco Graziella; Chen Shu; Powell Michael; Brooking Helen; Zanchetta Renato; Betterle Corrado; Smith Bernard Rees; Furmaniak Jadwiga
Analysis of the GAD65-GAD65 autoantibody interaction.
Clinica chimica acta; international journal of clinical chemistry 2008;391(1-2):51-9.
2007: Smith Bernard Rees; Sanders Jane; Furmaniak Jadwiga
TSH receptor antibodies.
Thyroid : official journal of the American Thyroid Association 2007;17(10):923-38.
2007: Sanders Jane; Miguel Ricardo Núñez; Bolton Jane; Bhardwaja Anshu; Sanders Paul; Nakatake Nobuhiro; Evans Michele; Furmaniak Jadwiga; Smith Bernard Rees
Molecular interactions between the TSH receptor and a Thyroid-stimulating monoclonal autoantibody.
Thyroid : official journal of the American Thyroid Association 2007;17(8):699-706.
2007: Sanders Jane; Chirgadze Dimitri Y; Sanders Paul; Baker Stuart; Sullivan Andrew; Bhardwaja Anshu; Bolton Jane; Reeve Magnus; Nakatake Nobuhiro; Evans Michele; Richards Tonya; Powell Michael; Miguel Ricardo Núñez; Blundell Tom L; Furmaniak Jadwiga; Smith Bernard Rees
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.
Thyroid : official journal of the American Thyroid Association 2007;17(5):395-410.
2006: Sanders Jane; Bolton Jane; Sanders Paul; Jeffreys Jennifer; Nakatake Nobuhiro; Richards Tonya; Evans Michele; Kiddie Angela; Summerhayes Sara; Roberts Emma; Miguel Ricardo Núñez; Furmaniak Jadwiga; Smith Bernard Rees
Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH.
Thyroid : official journal of the American Thyroid Association 2006;16(12):1195-206.
2006: Tonacchera M; Ferrarini E; Dimida A; Agretti P; De Marco G; Pinchera A; Sanders J; Evans M; Richards T; Furmaniak J; Smith B Rees
Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors.
Thyroid : official journal of the American Thyroid Association 2006;16(11):1085-9.
2006: Nakatake Nobuhiro; Sanders Jane; Richards Tonya; Burne Peter; Barrett Carol; Pra Chiara Dal; Presotto Fabio; Betterle Corrado; Furmaniak Jadwiga; Smith Bernard Rees
Estimation of serum TSH receptor autoantibody concentration and affinity.
Thyroid : official journal of the American Thyroid Association 2006;16(11):1077-84.
2006: Hewer Rachel; Matthews Ian; Chen Shu; McGrath Vivienne; Evans Michele; Roberts Emma; Nute Sarah; Sanders Jane; Furmaniak Jadwiga; Smith Bernard Rees
A sensitive non-isotopic assay for acetylcholine receptor autoantibodies.
Clinica chimica acta; international journal of clinical chemistry 2006;364(1-2):159-66.
2005: Miguel Ricardo Núñez; Chen Shu; Nikfarjam Laleh; Kominami Shiro; Carpenter Byron; Dal Pra Chiara; Betterle Corrado; Zanchetta Renato; Nakamatsu Takashi; Powell Michael; Hewer Rachel; Blundell Tom L; Smith Bernard Rees; Furmaniak Jadwiga
Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(6):949-61.
2005: Bakalov Vladimir K; Anasti James N; Calis Karim A; Vanderhoof Vien H; Premkumar Ahalya; Chen Shu; Furmaniak Jadwiga; Smith B Rees; Merino Maria J; Nelson Lawrence M
Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure.
Fertility and sterility 2005;84(4):958-65.
2005: Miguel Ricardo Núñez; Sanders Jane; Blundell Tom L; Smith Bernard Rees; Furmaniak Jadwiga
Comparative modeling of the thyrotropin receptor.
Thyroid : official journal of the American Thyroid Association 2005;15(7):746-7.
2005: Stankowiak-Kulpa Hanna; Sanders Jane; Depraetere Hilde; Jeffreys Jennifer; Evans Michele; Richards Tonya; Furmaniak Jadwiga; Smith Bernard Rees
A mouse monoclonal antibody to the TSHR.
Archivum immunologiae et therapiae experimentalis 2005;53(4):345-51.
2005: Sanders J; Allen F; Jeffreys J; Bolton J; Richards T; Depraetere H; Nakatake N; Evans M; Kiddie A; Premawardhana L D K E; Chirgadze D Y; Miguel R Núñez; Blundell T L; Furmaniak J; Smith B Rees
Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist.
Thyroid : official journal of the American Thyroid Association 2005;15(7):672-82.
2005: Chen Shu; Willis Jinny; Maclean Clare; Ananieva-Jordanova Rossitza; Amoroso Marie-Andrée; Brooking Helen; Powell Michael; Collins Anne; Bennett Stuart; Mitchell Sarah; Burne Peter; Furmaniak Jadwiga; Smith Bernard Rees
Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65.
Clinica chimica acta; international journal of clinical chemistry 2005;357(1):74-83.
2005: Ananieva-Jordanova R; Evans M; Nakamatsu T; Premawardhana L D K E; Sanders J; Powell M; Chen S; McGrath V; Belton C; Arnold C; Baker S; Betterle C; Zanchetta R; Smith B Rees; Furmaniak J
Isolation and characterisation of a human monoclonal autoantibody to the islet cell autoantigen IA-2.
Journal of autoimmunity 2005;24(4):337-45.
2005: Nikfarjam L; Kominami S; Yamazaki T; Chen S; Hewer R; Pra C Dal; Nakamatsu T; Betterle C; Zanchetta R; Smith B Rees; Furmaniak J
Mechanism of inhibition of cytochrome P450 C21 enzyme activity by autoantibodies from patients with Addison's disease.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(1):95-101.
2004: Smith Bernard Rees; Bolton Jane; Young Stuart; Collyer Alastair; Weeden Alison; Bradbury Janet; Weightman David; Perros Petros; Sanders Jane; Furmaniak Jadwiga
A new assay for thyrotropin receptor autoantibodies.
Thyroid : official journal of the American Thyroid Association 2004;14(10):830-5.
2004: Betterle C; Pra C Dal; Pedini B; Zanchetta R; Albergoni M P; Chen S; Furmaniak J; Smith B Rees
Assessment of adrenocortical function and autoantibodies in a baby born to a mother with autoimmune polyglandular syndrome Type 2.
Journal of endocrinological investigation 2004;27(7):618-21.
2003: Zöphel Klaus; Wunderlich Gerd; Smith Bernard Rees
Serum thyroglobulin measurements with a high sensitivity enzyme-linked immunosorbent assay: is there a clinical benefit in patients with differentiated thyroid carcinoma?
Thyroid : official journal of the American Thyroid Association 2003;13(9):861-5.
2003: Dal Pra C; Chen S; Furmaniak J; Smith B Rees; Pedini B; Moscon A; Zanchetta R; Betterle C
Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(5):565-70.
2003: Brooking Helen; Ananieva-Jordanova Rossitza; Arnold Clare; Amoroso Marie; Powell Michael; Betterle Corrado; Zanchetta Renato; Furmaniak Jadwiga; Smith Bernard Rees
A sensitive non-isotopic assay for GAD65 autoantibodies.
Clinica chimica acta; international journal of clinical chemistry 2003;331(1-2):55-9.
2002: Hayakawa N; Premawardhana L D K E; Powell M; Masuda M; Arnold C; Sanders J; Evans M; Chen S; Jaume J C; Baekkeskov S; Smith B Rees; Furmaniak J
Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase.
Autoimmunity 2002;35(5):343-55.
2001: Wunderlich G; Zöphel K; Crook L; Smith S; Smith B R; Franke W G
A high-sensitivity enzyme-linked immunosorbent assay for serum thyroglobulin.
Thyroid : official journal of the American Thyroid Association 2001;11(9):819-24.
2000: Oda Y; Sanders J; Evans M; Kiddie A; Munkley A; James C; Richards T; Wills J; Furmaniak J; Smith B R
Epitope analysis of the human thyrotropin (TSH) receptor using monoclonal antibodies.
Thyroid : official journal of the American Thyroid Association 2000;10(12):1051-9.
1999: Sanders J; Oda Y; Roberts S; Kiddie A; Richards T; Bolton J; McGrath V; Walters S; Jaskólski D; Furmaniak J; Smith B R
The interaction of TSH receptor autoantibodies with 125I-labelled TSH receptor.
The Journal of clinical endocrinology and metabolism 1999;84(10):3797-802.
1999: Oda Y; Sanders J; Roberts S; Maruyama M; Kiddie A; Furmaniak J; Smith B R
Analysis of carbohydrate residues on recombinant human thyrotropin receptor.
The Journal of clinical endocrinology and metabolism 1999;84(6):2119-25.
1999: Betterle C; Volpato M; Pedini B; Chen S; Smith B R; Furmaniak J
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
The Journal of clinical endocrinology and metabolism 1999;84(2):618-22.
1998: Chen S; Sawicka J; Prentice L; Sanders J F; Tanaka H; Petersen V; Betterle C; Volpato M; Roberts S; Powell M; Smith B R; Furmaniak J
Analysis of autoantibody epitopes on steroid 21-hydroxylase using a panel of monoclonal antibodies.
The Journal of clinical endocrinology and metabolism 1998;83(8):2977-86.
1997: Sanders J; Oda Y; Roberts S A; Maruyama M; Furmaniak J; Smith B R
Understanding the thyrotropin receptor function-structure relationship.
Baillière's clinical endocrinology and metabolism 1997;11(3):451-79.
1997: Akamine H; Komiya I; Shimabukuro T; Asawa T; Tanaka H; Yagi N; Taira T; Nagata K; Arakaki K; Wakugami T; Takasu N; Powell M J; Furmaniak J; Smith B R
High prevalence of GAD65 (and IA-2) antibodies in Japanese IDDM patients by a new immunoprecipitation assay based on recombinant human GAD65.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(9):778-84.
1997: Tanaka H; Perez M S; Powell M; Sanders J F; Sawicka J; Chen S; Prentice L; Asawa T; Betterle C; Volpato M; Smith B R; Furmaniak J
Steroid 21-hydroxylase autoantibodies: measurements with a new immunoprecipitation assay.
The Journal of clinical endocrinology and metabolism 1997;82(5):1440-6.
1997: Prentice L; Sanders J F; Perez M; Kato R; Sawicka J; Oda Y; Jaskolski D; Furmaniak J; Smith B R
Thyrotropin (TSH) receptor autoantibodies do not appear to bind to the TSH receptor produced in an in vitro transcription/translation system.
The Journal of clinical endocrinology and metabolism 1997;82(4):1288-92.
1997: Tanaka H; Asawa T; Powell M; Chen S; Smith B R; Furmaniak J
Autoantibody binding to steroid 21-hydroxylase--effect of five mutations.
Autoimmunity 1997;26(4):253-9.
1995: Colls J; Betterle C; Volpato M; Prentice L; Smith B R; Furmaniak J
Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases.
Clinical chemistry 1995;41(3):375-80.
1994: Furmaniak J; Kominami S; Asawa T; Wedlock N; Colls J; Smith B R
Autoimmune Addison's disease--evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency.
The Journal of clinical endocrinology and metabolism 1994;79(5):1517-21.
1994: Asawa T; Wedlock N; Baumann-Antczak A; Smith B R; Furmaniak J
Naturally occurring mutations in human steroid 21-hydroxylase influence adrenal autoantibody binding.
The Journal of clinical endocrinology and metabolism 1994;79(2):372-6.
1993: Wedlock N; Asawa T; Baumann-Antczak A; Smith B R; Furmaniak J
Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase.
FEBS letters 1993;332(1-2):123-6.
1993: Delves P J; McLachlan S M; Drewe E; Fukuma N; Petersen V B; Smith B R
Cross-reactive idiotypes on high affinity IgG class human monoclonal thyroglobulin autoantibodies.
Journal of autoimmunity 1993;6(1):77-91.
1993: Furmaniak J; Smith B R
Immunity to the thyroid-stimulating hormone receptor.
Springer seminars in immunopathology 1993;14(3):309-21.
1992: Baumann-Antczak A; Wedlock N; Bednarek J; Kiso Y; Krishnan H; Fowler S; Smith B R; Furmaniak J
Autoimmune Addison's disease and 21-hydroxylase.
Lancet 1992;340(8816):429-30.
1992: Hexham J M; Furmaniak J; Pegg C; Burton D R; Smith B R
Cloning of a human autoimmune response: preparation and sequencing of a human anti-thyroglobulin autoantibody using a combinatorial approach.
Autoimmunity 1992;12(2):135-41.
1992: Kiso Y; Furmaniak J; Morteo C; Smith B R
Analysis of carbohydrate residues on human thyroid peroxidase (TPO) and thyroglobulin (Tg) and effects of deglycosylation, reduction and unfolding on autoantibody binding.
Autoimmunity 1992;12(4):259-69.
1991: Phillips D; Prentice L; Upadhyaya M; Lunt P; Chamberlain S; Roberts D F; McLachlan S; Smith B R
Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease.
The Journal of clinical endocrinology and metabolism 1991;72(5):973-5.
1990: Prentice L M; Phillips D I; Sarsero D; Beever K; McLachlan S M; Smith B R
Geographical distribution of subclinical autoimmune thyroid disease in Britain: a study using highly sensitive direct assays for autoantibodies to thyroglobulin and thyroid peroxidase.
Acta endocrinologica 1990;123(5):493-8.
1990: Phillips D I; McLachlan S M; Smith B R; Bradbury J; Beever K
Autoantibodies to thyroglobulin and thyroid peroxidase in blood spots measured with a sensitive, direct radioimmunoassay.
Clinical chemistry 1990;36(5):823-4.
1990: Fukuma N; McLachlan S M; Petersen V B; Beever K; Smith B R
Relationship between thyroid autoantibody spectrotype and IgG subclass.
Autoimmunity 1990;6(1-2):37-45.
1990: McLachlan S M; Fukuma N; Sarsero D; Phillips D I; Petersen V B; Pegg C A; Baylis P; Smith B R
Potential role of PHA in producing human monoclonal thyroid autoantibodies of different subclasses.
Human antibodies and hybridomas 1990;1(3):166-70.
1990: Furmaniak J; Smith B R
The structure of thyroid autoantigens.
Autoimmunity 1990;7(1):63-80.
1989: Beever K; Bradbury J; Phillips D; McLachlan S M; Pegg C; Goral A; Overbeck W; Feifel G; Smith B R
Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase.
Clinical chemistry 1989;35(9):1949-54.
1989: Fukuma N; McLachlan S M; Petersen V B; Kau P; Bradbury J; Devey M; Bleasdale K; Grabowski P; Smith B R
Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin.
Immunology 1989;67(1):129-31.
1987: Nakajima Y; Howells R D; Pegg C; Jones E D; Smith B R
Structure-activity analysis of microsomal antigen/thyroid peroxidase.
Molecular and cellular endocrinology 1987;53(1-2):15-23.
1987: Forouhi N G; McLachlan S M; Middleton S L; Atherton M C; Baylis P; Clark F; Smith B R
T cell regulation of thyroglobulin autoantibody IgG subclasses in Hashimoto's thyroiditis.
Clinical and experimental immunology 1987;69(2):314-22.
1987: Furmaniak J; Hashim F A; Buckland P R; Petersen V B; Beever K; Howells R D; Smith B R
Photoaffinity labelling of the TSH receptor on FRTL5 cells.
FEBS letters 1987;215(2):316-22.
1987: McLachlan S M; Pegg C A; Atherton M C; Middleton S L; Dickinson A; Clark F; Smith B R
The thyroid microenvironment in autoimmune thyroid disease: effects of TSH and lymphokines on thyroid lymphocytes and thyroid cells.
Acta endocrinologica. Supplementum 1987;281():125-32.
1986: Furmaniak J; Jones E D; Buckland P R; Howells R D; Smith B R
Assessment of the shape and molecular size of TSH-TSH receptor complexes.
Molecular and cellular endocrinology 1986;48(1):31-8.
1986: Buckland P R; Rickards C R; Howells R D; Smith B R
Thyrotropin cross-links to the thyrotropin receptor through both the alpha and beta subunits.
The Biochemical journal 1986;235(3):879-82.
1985: Jones E D; Hashim F A; Creagh F M; Williams S E; Smith B R
The interaction between the TSH receptor and Graves' sera with TSH agonist or antagonist properties.
Molecular and cellular endocrinology 1985;41(2-3):257-61.
1985: McLachlan S M; Pegg C A; Atherton M C; Middleton S; Young E T; Clark F; Smith B R
The effect of carbimazole on thyroid autoantibody synthesis by thyroid lymphocytes.
The Journal of clinical endocrinology and metabolism 1985;60(6):1237-42.
1983: McLachlan S M; Fawcett J; Atherton M C; Thompson P; Baylis P; Smith B R
Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. II. Effect of thyroglobulin on thyroglobulin antibody synthesis.
Clinical and experimental immunology 1983;52(3):620-8.

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Bernard Rees Smith

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