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Bernard Rees Smith

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Noriko Isobe; Shu Chen; Jakub Fichna; Jadwiga Furmaniak; Katsuhisa Masaki; Takuya Matsushita; Bernard Rees Smith; Tomomi Yonekawa; Satoshi Yoshimura; Jun-Ichi Kira
Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica.
Noriko Isobe; Yuji Kawano; Shu Chen; Jakub Fichna; Jadwiga Furmaniak; Katsuhisa Masaki; Takuya Matsushita; Bernard Rees Smith; Tomomi Yonekawa; Satoshi Yoshimura; Jun-ichi Kira
Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica.
Simon H S Pearce; Bernard Rees Smith; Stuart Bennett; Sukesh Chandran; Shu Chen; John D Isaacs; Phil King; Anna L Mitchell; Sath Nag; Bijay Vaidya
Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease.

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2013: Noriko Isobe; Shu Chen; Jakub Fichna; Jadwiga Furmaniak; Katsuhisa Masaki; Takuya Matsushita; Bernard Rees Smith; Tomomi Yonekawa; Satoshi Yoshimura; Jun-Ichi Kira
Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica.
Neurochemical research 2013;38(5):997-1001.
2012: Noriko Isobe; Yuji Kawano; Shu Chen; Jakub Fichna; Jadwiga Furmaniak; Katsuhisa Masaki; Takuya Matsushita; Bernard Rees Smith; Tomomi Yonekawa; Satoshi Yoshimura; Jun-ichi Kira
Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica.
Multiple sclerosis (Houndmills, Basingstoke, England) 2012;18(11):1541-51.
2012: Simon H S Pearce; Bernard Rees Smith; Stuart Bennett; Sukesh Chandran; Shu Chen; John D Isaacs; Phil King; Anna L Mitchell; Sath Nag; Bijay Vaidya
Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease.
The Journal of clinical endocrinology and metabolism 2012;97(10):E1927-32.
2010: Michele Evans; Jane Sanders; Tetsuya Tagami; Paul Sanders; Stuart Young; Emma Roberts; Jane Wilmot; Xiaoling Hu; Katarzyna Kabelis; Jill Clark; Sabrina Holl; Tonya Richards; Alastair Collyer; Jadwiga Furmaniak; Bernard Rees Smith
Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample.
Clinical endocrinology 2010;73(3):404-12.
2009: Jadwiga Furmaniak; Jane Sanders; Bernard Rees Smith
Thyrotropin receptor structure--in the crystal new horizons shine.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2009;15(1):56-60.
2008: Bernard Rees Smith; Jadwiga Furmaniak; Jane Sanders
TSH receptor blocking antibodies.
Thyroid : official journal of the American Thyroid Association 2008;18(11):1239.
2008: Jane Sanders; Michele Evans; Corrado Betterle; Paul Sanders; Anshu Bhardwaja; Stuart Young; Emma Roberts; Jane Wilmot; Tonya Richards; Angela Kiddie; Kasemsri Small; Hayley Platt; Sara Summerhayes; Rebecca Harris; Magnus Reeve; Graziella Coco; Renato Zanchetta; Shu Chen; Jadwiga Furmaniak; Bernard Rees Smith
A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity.
Thyroid : official journal of the American Thyroid Association 2008;18(7):735-46.
2008: Graziella Coco; Shu Chen; Michael Powell; Helen Brooking; Renato Zanchetta; Corrado Betterle; Bernard Rees Smith; Jadwiga Furmaniak
Analysis of the GAD65-GAD65 autoantibody interaction.
Clinica chimica acta; international journal of clinical chemistry 2008;391(1-2):51-9.
2007: Bernard Rees Smith; Jane Sanders; Jadwiga Furmaniak
TSH receptor antibodies.
Thyroid : official journal of the American Thyroid Association 2007;17(10):923-38.
2007: Jane Sanders; Ricardo Núñez Miguel; Jane Bolton; Anshu Bhardwaja; Paul Sanders; Nobuhiro Nakatake; Michele Evans; Jadwiga Furmaniak; Bernard Rees Smith
Molecular interactions between the TSH receptor and a Thyroid-stimulating monoclonal autoantibody.
Thyroid : official journal of the American Thyroid Association 2007;17(8):699-706.
2007: Jane Sanders; Dimitri Y Chirgadze; Paul Sanders; Stuart Baker; Andrew Sullivan; Anshu Bhardwaja; Jane Bolton; Magnus Reeve; Nobuhiro Nakatake; Michele Evans; Tonya Richards; Michael Powell; Ricardo Núñez Miguel; Tom L Blundell; Jadwiga Furmaniak; Bernard Rees Smith
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.
Thyroid : official journal of the American Thyroid Association 2007;17(5):395-410.
2006: Jane Sanders; Jane Bolton; Paul Sanders; Jennifer Jeffreys; Nobuhiro Nakatake; Tonya Richards; Michele Evans; Angela Kiddie; Sara Summerhayes; Emma Roberts; Ricardo Núñez Miguel; Jadwiga Furmaniak; Bernard Rees Smith
Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH.
Thyroid : official journal of the American Thyroid Association 2006;16(12):1195-206.
2006: Massimo Tonacchera; Eleonora Ferrarini; Antonio Dimida; Patrizia Agretti; Giuseppina de Marco; Aldo Pinchera; J Sanders; M Evans; T Richards; J Furmaniak; Bernard Rees Smith
Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors.
Thyroid : official journal of the American Thyroid Association 2006;16(11):1085-9.
2006: Nobuhiro Nakatake; Jane Sanders; Tonya Richards; Peter Burne; Carol Barrett; Chiara Dal Pra; Fabio Presotto; Corrado Betterle; Jadwiga Furmaniak; Bernard Rees Smith
Estimation of serum TSH receptor autoantibody concentration and affinity.
Thyroid : official journal of the American Thyroid Association 2006;16(11):1077-84.
2006: Rachel Hewer; Ian Matthews; Shu Chen; Vivienne McGrath; Michele Evans; Emma Roberts; Sarah Nute; Jane Sanders; Jadwiga Furmaniak; Bernard Rees Smith
A sensitive non-isotopic assay for acetylcholine receptor autoantibodies.
Clinica chimica acta; international journal of clinical chemistry 2006;364(1-2):159-66.
2005: Ricardo Núñez Miguel; Shu Chen; Laleh Nikfarjam; Shiro Kominami; Byron Carpenter; Chiara Dal Pra; Corrado Betterle; Renato Zanchetta; Takashi Nakamatsu; Michael Powell; Rachel Hewer; Tom L Blundell; Bernard Rees Smith; Jadwiga Furmaniak
Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(6):949-61.
2005: Vladimir K Bakalov; James N Anasti; Karim A Calis; Vien H Vanderhoof; Ahalya Premkumar; Shu Chen; Jadwiga Furmaniak; Bernard Rees Smith; Maria J Merino; Lawrence M Nelson
Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure.
Fertility and sterility 2005;84(4):958-65.
2005: Ricardo Núñez Miguel; Jane Sanders; Tom L Blundell; Bernard Rees Smith; Jadwiga Furmaniak
Comparative modeling of the thyrotropin receptor.
Thyroid : official journal of the American Thyroid Association 2005;15(7):746-7.
2005: Hanna Stankowiak-Kulpa; Jane Sanders; Hilde Depraetere; Jennifer Jeffreys; Michele Evans; Tonya Richards; Jadwiga Furmaniak; Bernard Rees Smith
A mouse monoclonal antibody to the TSHR.
Archivum immunologiae et therapiae experimentalis 2005;53(4):345-51.
2005: Jane Sanders; F Allen; Jennifer Jeffreys; Jane Bolton; Tonya Richards; Hilde Depraetere; Nobuhiro Nakatake; Michele Evans; Angela Kiddie; L D K E Premawardhana; Dimitri Y Chirgadze; Ricardo Núñez Miguel; Tom L Blundell; Jadwiga Furmaniak; Bernard Rees Smith
Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist.
Thyroid : official journal of the American Thyroid Association 2005;15(7):672-82.
2005: Shu Chen; Jinny Willis; Clare Maclean; Rossitza Ananieva-Jordanova; Marie-Andrée Amoroso; Helen Brooking; Michael Powell; Anne Collins; Stuart Bennett; Sarah Mitchell; Peter Burne; Jadwiga Furmaniak; Bernard Rees Smith
Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65.
Clinica chimica acta; international journal of clinical chemistry 2005;357(1):74-83.
2005: Rossitza Ananieva-Jordanova; Michele Evans; Takashi Nakamatsu; L D K E Premawardhana; Jane Sanders; Michael Powell; Shu Chen; Vivienne McGrath; C Belton; Clare Arnold; S Baker; Corrado Betterle; Renato Zanchetta; Bernard Rees Smith; Jadwiga Furmaniak
Isolation and characterisation of a human monoclonal autoantibody to the islet cell autoantigen IA-2.
Journal of autoimmunity 2005;24(4):337-45.
2005: Laleh Nikfarjam; Shiro Kominami; Takeshi Yamazaki; Shu Chen; Rachel Hewer; C Dal Pra; Takashi Nakamatsu; Corrado Betterle; Renato Zanchetta; Bernard Rees Smith; Jadwiga Furmaniak
Mechanism of inhibition of cytochrome P450 C21 enzyme activity by autoantibodies from patients with Addison's disease.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(1):95-101.
2004: Bernard Rees Smith; Jane Bolton; Stuart Young; Alastair Collyer; Alison Weeden; Janet Bradbury; David R Weightman; Petros Perros; Jane Sanders; Jadwiga Furmaniak
A new assay for thyrotropin receptor autoantibodies.
Thyroid : official journal of the American Thyroid Association 2004;14(10):830-5.
2004: Corrado Betterle; C Dal Pra; Beniamino Pedini; Renato Zanchetta; Maria Paola Albergoni; Shu Chen; Jadwiga Furmaniak; Bernard Rees Smith
Assessment of adrenocortical function and autoantibodies in a baby born to a mother with autoimmune polyglandular syndrome Type 2.
Journal of endocrinological investigation 2004;27(7):618-21.
2003: Klaus Zöphel; Gerd Wunderlich; Bernard Rees Smith
Serum thyroglobulin measurements with a high sensitivity enzyme-linked immunosorbent assay: is there a clinical benefit in patients with differentiated thyroid carcinoma?
Thyroid : official journal of the American Thyroid Association 2003;13(9):861-5.
2003: Chiara Dal Pra; Shu Chen; Jadwiga Furmaniak; Bernard Rees Smith; Beniamino Pedini; Alessandro Moscon; Renato Zanchetta; Corrado Betterle
Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(5):565-70.
2003: Helen Brooking; Rossitza Ananieva-Jordanova; Clare Arnold; Marie-Andrée Amoroso; Michael Powell; Corrado Betterle; Renato Zanchetta; Jadwiga Furmaniak; Bernard Rees Smith
A sensitive non-isotopic assay for GAD65 autoantibodies.
Clinica chimica acta; international journal of clinical chemistry 2003;331(1-2):55-9.
2002: N Hayakawa; L D K E Premawardhana; Michael Powell; M Masuda; Clare Arnold; Jane Sanders; M Evans; Shu Chen; Juan Carlos Jaume; Steinunn Baekkeskov; Bernard Rees Smith; Jadwiga Furmaniak
Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase.
Autoimmunity 2002;35(5):343-55.
2001: Gerd Wunderlich; Klaus Zöphel; L Crook; S Smith; Bernard Rees Smith; Wolf-Gunter Franke
A high-sensitivity enzyme-linked immunosorbent assay for serum thyroglobulin.
Thyroid : official journal of the American Thyroid Association 2001;11(9):819-24.
2000: Yasuo Oda; Jane Sanders; Michele Evans; Angela Kiddie; A Munkley; C James; Tonya Richards; J Wills; Jadwiga Furmaniak; Bernard Rees Smith
Epitope analysis of the human thyrotropin (TSH) receptor using monoclonal antibodies.
Thyroid : official journal of the American Thyroid Association 2000;10(12):1051-9.
1999: Jane Sanders; Yasuo Oda; S Roberts; Angela Kiddie; Tonya Richards; Jane Bolton; Vivienne McGrath; S Walters; D Jaskólski; Jadwiga Furmaniak; Bernard Rees Smith
The interaction of TSH receptor autoantibodies with 125I-labelled TSH receptor.
The Journal of clinical endocrinology and metabolism 1999;84(10):3797-802.
1999: Yasuo Oda; Jane Sanders; S Roberts; M Maruyama; Angela Kiddie; Jadwiga Furmaniak; Bernard Rees Smith
Analysis of carbohydrate residues on recombinant human thyrotropin receptor.
The Journal of clinical endocrinology and metabolism 1999;84(6):2119-25.
1999: Corrado Betterle; M Volpato; Beniamino Pedini; Shu Chen; Bernard Rees Smith; Jadwiga Furmaniak
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
The Journal of clinical endocrinology and metabolism 1999;84(2):618-22.
1998: Shu Chen; J Sawicka; L Prentice; JF Sanders; H Tanaka; V Petersen; Corrado Betterle; M Volpato; S Roberts; Michael Powell; Bernard Rees Smith; Jadwiga Furmaniak
Analysis of autoantibody epitopes on steroid 21-hydroxylase using a panel of monoclonal antibodies.
The Journal of clinical endocrinology and metabolism 1998;83(8):2977-86.
1997: Jane Sanders; Y Oda; S A Roberts; M Maruyama; Jadwiga Furmaniak; Bernard Rees Smith
Understanding the thyrotropin receptor function-structure relationship.
Baillière's clinical endocrinology and metabolism 1997;11(3):451-79.
1997: Hiromitsu Akamine; Ichiro Komiya; T Shimabukuro; T Asawa; H Tanaka; N Yagi; T Taira; K Nagata; K Arakaki; T Wakugami; Nobuyuki Takasu; M J Powell; Jadwiga Furmaniak; Bernard Rees Smith
High prevalence of GAD65 (and IA-2) antibodies in Japanese IDDM patients by a new immunoprecipitation assay based on recombinant human GAD65.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(9):778-84.
1997: H Tanaka; M S Perez; Michael Powell; JF Sanders; J Sawicka; Shu Chen; L Prentice; T Asawa; Corrado Betterle; M Volpato; Bernard Rees Smith; Jadwiga Furmaniak
Steroid 21-hydroxylase autoantibodies: measurements with a new immunoprecipitation assay.
The Journal of clinical endocrinology and metabolism 1997;82(5):1440-6.
1997: L Prentice; JF Sanders; M Perez; R Kato; J Sawicka; Y Oda; D Jaskolski; Jadwiga Furmaniak; Bernard Rees Smith
Thyrotropin (TSH) receptor autoantibodies do not appear to bind to the TSH receptor produced in an in vitro transcription/translation system.
The Journal of clinical endocrinology and metabolism 1997;82(4):1288-92.
1997: H Tanaka; T Asawa; Michael Powell; Shu Chen; Bernard Rees Smith; Jadwiga Furmaniak
Autoantibody binding to steroid 21-hydroxylase--effect of five mutations.
Autoimmunity 1997;26(4):253-9.
1995: J Colls; Corrado Betterle; M Volpato; L Prentice; Bernard Rees Smith; Jadwiga Furmaniak
Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases.
Clinical chemistry 1995;41(3):375-80.
1994: Jadwiga Furmaniak; S Kominami; T Asawa; N Wedlock; J Colls; Bernard Rees Smith
Autoimmune Addison's disease--evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency.
The Journal of clinical endocrinology and metabolism 1994;79(5):1517-21.
1994: T Asawa; N Wedlock; A Baumann-Antczak; Bernard Rees Smith; Jadwiga Furmaniak
Naturally occurring mutations in human steroid 21-hydroxylase influence adrenal autoantibody binding.
The Journal of clinical endocrinology and metabolism 1994;79(2):372-6.
1993: N Wedlock; T Asawa; A Baumann-Antczak; Bernard Rees Smith; Jadwiga Furmaniak
Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase.
FEBS letters 1993;332(1-2):123-6.
1993: Peter J Delves; S M McLachlan; E Drewe; N Fukuma; V B Petersen; Bernard Rees Smith
Cross-reactive idiotypes on high affinity IgG class human monoclonal thyroglobulin autoantibodies.
Journal of autoimmunity 1993;6(1):77-91.
1993: Jadwiga Furmaniak; Bernard Rees Smith
Immunity to the thyroid-stimulating hormone receptor.
Springer seminars in immunopathology 1993;14(3):309-21.
1992: A Baumann-Antczak; N Wedlock; J Bednarek; Y Kiso; H Krishnan; S Fowler; Bernard Rees Smith; Jadwiga Furmaniak
Autoimmune Addison's disease and 21-hydroxylase.
Lancet 1992;340(8816):429-30.
1992: J M Hexham; Jadwiga Furmaniak; C Pegg; D R Burton; Bernard Rees Smith
Cloning of a human autoimmune response: preparation and sequencing of a human anti-thyroglobulin autoantibody using a combinatorial approach.
Autoimmunity 1992;12(2):135-41.
1992: Y Kiso; Jadwiga Furmaniak; C Morteo; Bernard Rees Smith
Analysis of carbohydrate residues on human thyroid peroxidase (TPO) and thyroglobulin (Tg) and effects of deglycosylation, reduction and unfolding on autoantibody binding.
Autoimmunity 1992;12(4):259-69.
1991: D Phillips; L Prentice; M Upadhyaya; P Lunt; S Chamberlain; D F Roberts; S McLachlan; Bernard Rees Smith
Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease.
The Journal of clinical endocrinology and metabolism 1991;72(5):973-5.
1990: L Prentice; David Phillips; D Sarsero; K Beever; S M McLachlan; Bernard Rees Smith
Geographical distribution of subclinical autoimmune thyroid disease in Britain: a study using highly sensitive direct assays for autoantibodies to thyroglobulin and thyroid peroxidase.
Acta endocrinologica 1990;123(5):493-8.
1990: David Phillips; S M McLachlan; Bernard Rees Smith; J Bradbury; K Beever
Autoantibodies to thyroglobulin and thyroid peroxidase in blood spots measured with a sensitive, direct radioimmunoassay.
Clinical chemistry 1990;36(5):823-4.
1990: N Fukuma; S M McLachlan; V B Petersen; K Beever; Bernard Rees Smith
Relationship between thyroid autoantibody spectrotype and IgG subclass.
Autoimmunity 1990;6(1-2):37-45.
1990: S M McLachlan; N Fukuma; D Sarsero; David Phillips; V B Petersen; C A Pegg; P Baylis; Bernard Rees Smith
Potential role of PHA in producing human monoclonal thyroid autoantibodies of different subclasses.
Human antibodies and hybridomas 1990;1(3):166-70.
1990: Jadwiga Furmaniak; Bernard Rees Smith
The structure of thyroid autoantigens.
Autoimmunity 1990;7(1):63-80.
1989: K Beever; J Bradbury; D Phillips; S M McLachlan; C Pegg; A Goral; W Overbeck; G Feifel; Bernard Rees Smith
Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase.
Clinical chemistry 1989;35(9):1949-54.
1989: N Fukuma; S M McLachlan; V B Petersen; P Kau; J Bradbury; M Devey; K Bleasdale; Peter Stanislaw Grabowski; Bernard Rees Smith
Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin.
Immunology 1989;67(1):129-31.
1987: Y Nakajima; R D Howells; C Pegg; E D Jones; Bernard Rees Smith
Structure-activity analysis of microsomal antigen/thyroid peroxidase.
Molecular and cellular endocrinology 1987;53(1-2):15-23.
1987: N G Forouhi; S M McLachlan; S L Middleton; M C Atherton; P Baylis; F Clark; Bernard Rees Smith
T cell regulation of thyroglobulin autoantibody IgG subclasses in Hashimoto's thyroiditis.
Clinical and experimental immunology 1987;69(2):314-22.
1987: Jadwiga Furmaniak; F A Hashim; P R Buckland; V B Petersen; K Beever; R D Howells; Bernard Rees Smith
Photoaffinity labelling of the TSH receptor on FRTL5 cells.
FEBS letters 1987;215(2):316-22.
1987: S M McLachlan; C A Pegg; M C Atherton; S L Middleton; A Dickinson; F Clark; Bernard Rees Smith
The thyroid microenvironment in autoimmune thyroid disease: effects of TSH and lymphokines on thyroid lymphocytes and thyroid cells.
Acta endocrinologica. Supplementum 1987;281():125-32.
1986: Jadwiga Furmaniak; E D Jones; P R Buckland; R D Howells; Bernard Rees Smith
Assessment of the shape and molecular size of TSH-TSH receptor complexes.
Molecular and cellular endocrinology 1986;48(1):31-8.
1986: P R Buckland; C R Rickards; R D Howells; Bernard Rees Smith
Thyrotropin cross-links to the thyrotropin receptor through both the alpha and beta subunits.
The Biochemical journal 1986;235(3):879-82.
1985: E D Jones; F A Hashim; F M Creagh; S E Williams; Bernard Rees Smith
The interaction between the TSH receptor and Graves' sera with TSH agonist or antagonist properties.
Molecular and cellular endocrinology 1985;41(2-3):257-61.
1985: S M McLachlan; C A Pegg; M C Atherton; S Middleton; E T Young; F Clark; Bernard Rees Smith
The effect of carbimazole on thyroid autoantibody synthesis by thyroid lymphocytes.
The Journal of clinical endocrinology and metabolism 1985;60(6):1237-42.
1983: S M McLachlan; J Fawcett; M C Atherton; P Thompson; P Baylis; Bernard Rees Smith
Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. II. Effect of thyroglobulin on thyroglobulin antibody synthesis.
Clinical and experimental immunology 1983;52(3):620-8.