FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Smith

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Concepts & Ideas

Co-author Network

Publications

TOP 3
Yeamin Huh; Scott M Hynes; David E Smith; Meihua R Feng
Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.
David E Smith; Benjamin Clémençon; Matthias A Hediger
Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.
Maria M Posada; David E Smith
Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Smith (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Yeamin Huh; Scott M Hynes; David E Smith; Meihua R Feng
Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.
Pharmaceutical research 2013;30(5):1423-34.
2013: David E Smith; Benjamin Clémençon; Matthias A Hediger
Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.
Molecular aspects of medicine 2013;34(2-3):323-36.
2013: Maria M Posada; David E Smith
Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil.
Pharmaceutical research 2013;30(4):1017-25.
2013: Bei Yang; David E Smith
Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(3):608-14.
2013: Shu-Pei Wu; David E Smith
Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide.
Molecular pharmaceutics 2013;10(2):677-84.
2012: David E Smith; Kathleen M Giacomini; Malcolm Rowland; Gordon L Amidon
Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!
Pharmaceutical research 2012;29(9):2345-53.
2012: Mary Feng; Meihua Rose Feng; James A Knol; Zheng Lu; Daniel Normolle; Charlie C Pan; David E Smith; Edgar Ben-Josef; Jun Chen; William D Ensminger; Theodore S Lawrence
A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy.
International journal of radiation oncology, biology, physics 2012;83(5):1441-7.
2012: Yongjun Hu; Xiaomei Chen; David E Smith
Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(7):1328-35.
2012: Ke Ma; Yongjun Hu; David E Smith
Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice.
Pharmaceutical research 2012;29(2):535-45.
2011: Dilara Jappar; Yongjun Hu; David E Smith
Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2250-7.
2011: Yeamin Huh; David E Smith; Meihau Rose Feng
Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs.
Xenobiotica; the fate of foreign compounds in biological systems 2011;41(11):972-87.
2011: Katherine Ma; Yongjun Hu; David E Smith
Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null mice.
Journal of pharmaceutical sciences 2011;100(2):767-74.
2011: Richard F Keep; David E Smith
Choroid plexus transport: gene deletion studies.
Fluids and barriers of the CNS 2011;8(1):26.
2011: David E Smith; Yongjun Hu; Hong Shen; Tavarekere N Nagaraja; Joseph D Fenstermacher; Richard F Keep
Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(1):250-61.
2010: Dilara Jappar; Shu-Pei Wu; Yongjun Hu; David E Smith
Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(10):1740-6.
2010: Jianming Xiang; Huidi Jiang; Yongjun Hu; David E Smith; Richard F Keep
Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.
Brain research 2010;1347():11-8.
2009: Huidi Jiang; Yongjun Hu; Richard F Keep; David E Smith
Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice.
Journal of neurochemistry 2009;109(5):1536-43.
2009: Noemí Marina-García; luigi franchi; Yun-Gi Kim; Yonjun Hu; David E Smith; Gerardus Josephus Boons; Gabriel Núñez
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4321-7.
2008: Yongun Hu; David E Smith; Ke Ma; Dilara Jappar; Winston Thomas; Kathleen M Hillgren
Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine.
Molecular pharmaceutics 2008;5(6):1122-30.
2008: Mohamed A Kamal; Richard F Keep; David E Smith
Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity.
Drug metabolism and pharmacokinetics 2008;23(4):236-42.
2007: Yongjun Hu; Hong Shen; Richard F Keep; David E Smith
Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity.
Journal of neurochemistry 2007;103(5):2058-65.
2007: Theresa V Nguyen; David Fleisher; David E Smith
In vivo effects of glycyl-glutamate and glycyl-sarcosine on gabapentin oral absorption in rat.
Pharmaceutical research 2007;24(8):1538-43.
2007: Hong Shen; Scott M Ocheltree; Yongjun Hu; Richard F Keep; David E Smith
Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1209-16.
2007: Theresa V Nguyen; David E Smith; David Fleisher
PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange.
Pharmaceutical research 2007;24(2):353-60.
2006: Jianming Xiang; Yongjun Hu; David E Smith; Richard F Keep
PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes.
Brain research 2006;1122(1):18-23.
2006: Jianming Xiang; Pei-Pei Chiang; Yongjun Hu; David E Smith; Richard F Keep
Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures.
Neuroscience letters 2006;396(3):225-9.
2005: Hong Shen; Richard F Keep; Yongjun Hu; David E Smith
PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1101-8.
2005: Scott M Ocheltree; Hong Shen; Yongjun Hu; Richard F Keep; David E Smith
Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice.
The Journal of pharmacology and experimental therapeutics 2005;315(1):240-7.
2005: Yongjun Hu; Scott M Ocheltree; Jianming Xiang; Richard F Keep; David E Smith
Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2.
Pharmaceutical research 2005;22(8):1281-6.
2005: Jun Chen; Zheng Lu; Theodore S Lawrence; David E Smith
Determination of WR-1065 in human blood by high-performance liquid chromatography following fluorescent derivatization by a maleimide reagent ThioGlo3.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;819(1):161-7.
2005: Nabeel B Nabulsi; David E Smith; Michael R Kilbourn
[11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice.
Bioorganic & medicinal chemistry 2005;13(8):2993-3001.
2004: David E Smith; Conrad E Johanson; Richard F Keep
Peptide and peptide analog transport systems at the blood-CSF barrier.
Advanced drug delivery reviews 2004;56(12):1765-91.
2004: Scott M Ocheltree; Hong Shen; Yongjun Hu; Jianming Xiang; Richard F Keep; David E Smith
Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice.
Pharmaceutical research 2004;21(9):1680-5.
2004: Hong Shen; David E Smith; Richard F Keep; Frank C Brosius III
Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain.
Molecular pharmaceutics 2004;1(4):248-56.
2004: Nathan S Teuscher; Hong Shen; Cathaleen Shu; Jianming Xiang; Richard F Keep; David E Smith
Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice.
Journal of neurochemistry 2004;89(2):375-82.
2004: Scott M Ocheltree; Hong Shen; Yongjun Hu; Jianming Xiang; Richard F Keep; David E Smith
Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice.
The Journal of pharmacology and experimental therapeutics 2004;308(2):462-7.
2004: Micha Levi; Susan J DeRemer; Chunzhi Dou; William D Ensminger; David E Smith
Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine.
Biopharmaceutics & drug disposition 2004;25(1):27-35.
2003: Scott M Ocheltree; Richard F Keep; Hong Shen; Dongli Yang; Bret A Hughes; David E Smith
Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes.
Pharmaceutical research 2003;20(9):1364-72.
2003: Hong Shen; David E Smith; Richard F Keep; Jianming Xiang; Frank C Brosius III
Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.
The Journal of biological chemistry 2003;278(7):4786-91.
2003: Steven R Ennis; A Novotny; Jianming Xiang; Parvin Shakui; Tetsuya Masada; Walter Stummer; David E Smith; Richard F Keep
Transport of 5-aminolevulinic acid between blood and brain.
Brain research 2003;959(2):226-34.
2002: Micha Levi; James A Knol; William D Ensminger; Susan J DeRemer; Chunzhi Dou; Susan M Lunte; Heather S Bonner; Leslie M Shaw; David E Smith
Regional pharmacokinetics of amifostine in anesthetized dogs: role of the liver, gastrointestinal tract, lungs, and kidneys.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1425-30.
2002: Cathaleen Shu; Hong Shen; Nathan S Teuscher; Philip J Lorenzi; Richard F Keep; David E Smith
Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture.
The Journal of pharmacology and experimental therapeutics 2002;301(3):820-9.
2001: C Shu; Hong Shen; U Hopfer; David E Smith
Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(10):1307-15.
2001: Nathan S Teuscher; Richard F Keep; David E Smith
PEPT2-mediated uptake of neuropeptides in rat choroid plexus.
Pharmaceutical research 2001;18(6):807-13.
2001: Zvi Symon; Micha Levi; William D Ensminger; David E Smith; Theodore S Lawrence
Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model.
International journal of radiation oncology, biology, physics 2001;50(2):473-8.
2000: Nathan S Teuscher; A Novotny; Richard F Keep; David E Smith
Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine.
The Journal of pharmacology and experimental therapeutics 2000;294(2):494-9.
2000: A Novotny; Jianming Xiang; Walter Stummer; Nathan S Teuscher; David E Smith; Richard F Keep
Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus.
Journal of neurochemistry 2000;75(1):321-8.
2000: T Zhu; X Z Chen; A Steel; M A Hediger; David E Smith
Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2.
Pharmaceutical research 2000;17(5):526-32.
1999: CJ Lin; W Akarawut; David E Smith
Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter.
Pharmaceutical research 1999;16(5):609-15.
1999: H Shen; David E Smith; Tianxin Yang; Yuning G Huang; Jurgen Schnermann; Frank C Brosius III
Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney.
The American journal of physiology 1999;276(5 Pt 2):F658-65.
1999: CJ Lin; David E Smith
Glycylsarcosine uptake in rabbit renal brush border membrane vesicles isolated from outer cortex or outer medulla: evidence for heterogeneous distribution of oligopeptide transporters.
AAPS pharmSci 1999;1(2):E1.
1998: W Akarawut; CJ Lin; David E Smith
Noncompetitive inhibition of glycylsarcosine transport by quinapril in rabbit renal brush border membrane vesicles: effect on high-affinity peptide transporter.
The Journal of pharmacology and experimental therapeutics 1998;287(2):684-90.
1998: David E Smith; A Pavlova; U V Berger; M A Hediger; Tianxin Yang; Yuning G Huang; Jurgen Schnermann
Tubular localization and tissue distribution of peptide transporters in rat kidney.
Pharmaceutical research 1998;15(8):1244-9.
1998: W Akarawut; David E Smith
Competitive inhibition of p-aminohippurate transport by quinapril in rabbit renal basolateral membrane vesicles.
Journal of pharmacokinetics and biopharmaceutics 1998;26(3):269-87.
1998: H Y Kuan; David E Smith; William D Ensminger; James A Knol; Susan J DeRemer; Z Yang; PL Stetson
Regional pharmacokinetics of 5-fluorouracil in dogs: role of the liver, gastrointestinal tract, and lungs.
Cancer research 1998;58(8):1688-94.
1998: Nasir Idkaidek; Gordon L Amidon; David E Smith; Naji M Najib; M M Hassan
Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM.
Biopharmaceutics & drug disposition 1998;19(3):169-74.
1997: C L Cheng; David E Smith; Peggy L Carver; S R Cox; Paul B Watkins; D S Blake; Carol A Kauffman; K M Meyer; Gordon L Amidon; PL Stetson
Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test.
Clinical pharmacology and therapeutics 1997;61(5):531-43.
1996: H Y Kuan; David E Smith; W D Ensmiger; James A Knol; S J DeRemer; Z Yang; PL Stetson
Regional pharmacokinetics of 5-bromo-2'-deoxyuridine and 5-fluorouracil in dogs: hepatic arterial versus portal venous infusions.
Cancer research 1996;56(20):4724-7.
1995: David E Smith; A R Kugler; Jurgen Schnermann
Reabsorption and metabolism of quinapril and quinaprilat in rat kidney: in vivo micropuncture studies.
Journal of pharmaceutical sciences 1995;84(10):1147-50.
1994: David E Smith; J K Paliwal; S R Cox; R R Berardi; V A Dunn-Kucharski; Grace H Elta
The effect of competitive and non-linear plasma protein binding on the stereoselective disposition and metabolic inversion of ibuprofen in healthy subjects.
Biopharmaceutics & drug disposition 1994;15(7):545-61.
1993: J K Paliwal; David E Smith; S R Cox; R R Berardi; V A Dunn-Kucharski; Grace H Elta
Stereoselective, competitive, and nonlinear plasma protein binding of ibuprofen enantiomers as determined in vivo in healthy subjects.
Journal of pharmacokinetics and biopharmaceutics 1993;21(2):145-61.
1993: David E Smith; Dean E Brenner; C A Knutsen; S J Deremer; P A Terrio; N J Johnson; PL Stetson; William D Ensminger
Mutual kinetic interaction between 5-fluorouracil and bromodeoxyuridine or iododeoxyuridine in dogs.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):277-83.
1992: D Kim Turgeon; Daniel Normolle; Alan B Leichtman; Thomas M Annesley; David E Smith; Paul B Watkins
Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients.
Clinical pharmacology and therapeutics 1992;52(5):471-8.
1992: David E Smith; S Guillard; C A Rodríguez
Effect of angiotensin II-induced changes in perfusion flow rate on chlorothiazide transport in the isolated perfused rat kidney.
Journal of pharmacokinetics and biopharmaceutics 1992;20(2):195-207.
1991: H Y Ahn; F Jamali; S R Cox; D Kittayanond; David E Smith
Stereoselective disposition of ibuprofen enantiomers in the isolated perfused rat kidney.
Pharmaceutical research 1991;8(12):1520-4.
1991: Nancy Janiczek; HN Bockbrader; T Chang; Gordon L Amidon; David E Smith
Stereoselective high-performance liquid chromatographic assay for pirmenol enantiomers in dog plasma.
Journal of chromatography 1991;571(1-2):179-87.
1991: H Y Ahn; Gordon L Amidon; David E Smith
Stereoselective systemic disposition of ibuprofen enantiomers in the dog.
Pharmaceutical research 1991;8(9):1186-90.
1989: L J Lee; David E Smith
Effect of organ perfusion on renal drug transport. Application to furosemide in the isolated perfused rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(1):32-6.
1988: L J Lee; David E Smith
Renal excretion and metabolism of p-aminohippurate in the isolated perfused rat kidney.
Pharmaceutical research 1988;5(11):745-7.
1988: J A Cook; David E Smith; L A Cornish; R M Tankanow; John M Nicklas; M L Hyneck
Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with congestive heart failure.
Clinical pharmacology and therapeutics 1988;44(5):487-500.
1988: L J Lee; J A Cook; David E Smith
Renal transport kinetics of chlorothiazide in the isolated perfused rat kidney.
The Journal of pharmacology and experimental therapeutics 1988;247(1):203-8.
1988: J A Cook; David E Smith
Development of acute tolerance to bumetanide: constant-rate infusion studies.
Pharmaceutical research 1988;5(2):86-91.
1987: J A Cook; David E Smith
Development of acute tolerance to bumetanide: bolus injection studies.
Pharmaceutical research 1987;4(5):379-84.
1986: H S Lau; M L Hyneck; R R Berardi; Richard D Swartz; David E Smith
Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with chronic renal failure.
Clinical pharmacology and therapeutics 1986;39(6):635-45.
1985: David E Smith; M L Hyneck; R R Berardi; Friedrich K Port
Urinary protein binding, kinetics, and dynamics of furosemide in nephrotic patients.
Journal of pharmaceutical sciences 1985;74(6):603-7.