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Edwin Smith

Research Profile

Disorders

Anatomy

Chemicals & Drugs

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Physiology

Gene Expression Regulation

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Publications

TOP 3
Laura B Hughes; Richard J Reynolds; Elizabeth E Brown; James M Kelley; Brian Thomson; Doyt L Conn; Beth L Jonas; Andrew Westfall; Miguel A Padilla; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; Robert M Plenge; S Louis Bridges
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.
Jie Zhang; David T Redden; Gerald McGwin; Leigh F Callahan; Edwin A Smith; Graciela S Alarcón; Larry W Moreland; Désirée M van der Heijde; Elizabeth E Brown; Donna K Arnett; Ted R Mikuls; S Louis Bridges
Generalized bone loss as a predictor of three-year radiographic damage in African American patients with recent-onset rheumatoid arthritis.
S Louis Bridges; Zenoria L Causey; Paula I Burgos; B Quynh N Huynh; Laura B Hughes; Maria I Danila; Amalia van Everdingen; Stephanie Ledbetter; Doyt L Conn; Ashutosh Tamhane; Andrew O Westfall; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard Brasington; Larry W Moreland; Graciela S Alarcón; Désirée M van der Heijde
Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study.

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All Publications

2010: Laura B Hughes; Richard J Reynolds; Elizabeth E Brown; James M Kelley; Brian Thomson; Doyt L Conn; Beth L Jonas; Andrew Westfall; Miguel A Padilla; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; Robert M Plenge; S Louis Bridges
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.
Arthritis and rheumatism 2010;62(12):3547-53.
2010: Jie Zhang; David T Redden; Gerald McGwin; Leigh F Callahan; Edwin A Smith; Graciela S Alarcón; Larry W Moreland; Désirée M van der Heijde; Elizabeth E Brown; Donna K Arnett; Ted R Mikuls; S Louis Bridges
Generalized bone loss as a predictor of three-year radiographic damage in African American patients with recent-onset rheumatoid arthritis.
Arthritis and rheumatism 2010;62(8):2219-26.
2010: S Louis Bridges; Zenoria L Causey; Paula I Burgos; B Quynh N Huynh; Laura B Hughes; Maria I Danila; Amalia van Everdingen; Stephanie Ledbetter; Doyt L Conn; Ashutosh Tamhane; Andrew O Westfall; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard Brasington; Larry W Moreland; Graciela S Alarcón; Désirée M van der Heijde
Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study.
Arthritis care & research 2010;62(5):624-31.
2010: James M Kelley; Laura B Hughes; Ashima Malik; Maria I Danila; Yuanqing Edberg; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; S Louis Bridges
Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.
Annals of the rheumatic diseases 2010;69(4):625-6.
2010: Steven M Craig; Fang Yu; Jeffrey R Curtis; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Larry W Moreland; S Louis Bridges; Ted R Mikuls
Vitamin D status and its associations with disease activity and severity in African Americans with recent-onset rheumatoid arthritis.
The Journal of rheumatology 2010;37(2):275-81.
2010: Paula I Burgos; Zenoria L Causey; Ashutosh Tamhane; James M Kelley; Elizabeth E Brown; Laura B Hughes; Maria I Danila; Amalia van Everdingen; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Larry W Moreland; Désirée M van der Heijde; Graciela S Alarcón; S Louis Bridges
Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis.
Arthritis research & therapy 2010;12(3):R75.
2009: James M Kelley; Laura B Hughes; Jeffrey D Faggard; Maria I Danila; Monica H Crawford; Yuanqing Edberg; Miguel A Padilla; Hemant K Tiwari; Andrew Westfall; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; David Allison; Robert P Kimberly; Larry W Moreland; Jeffrey C Edberg; S Louis Bridges
Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.
PLoS genetics 2009;5(12):.
2009: James M Kelley; Laura B Hughes; Jeffrey D Faggard; Maria I Danila; Monica H Crawford; Yuanqing Edberg; Miguel A Padilla; Hemant K Tiwari; Andrew Westfall; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; David Allison; Robert P Kimberly; Larry W Moreland; Jeffrey C Edberg; S Louis Bridges
An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.
PLoS genetics 2009;5(3):e1000424.
2008: Ted R Mikuls; L B Hughes; Andrew Westfall; V Michael Holers; Lezlie A Parrish; D van der Heijde; M van Everdingen; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Gary S Gilkeson; George Howard; Larry W Moreland; S Louis Bridges
Cigarette smoking, disease severity and autoantibody expression in African Americans with recent-onset rheumatoid arthritis.
Annals of the rheumatic diseases 2008;67(11):1529-34.
2008: Jaspreet Pannu; Yoshihide Asano; SASHIDHAR NAKERAKANTI; Edwin A Smith; Stefania Jablonska; Maria Blaszczyk; Peter ten Dijke; Maria Trojanowska
Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate.
Arthritis and rheumatism 2008;58(8):2528-37.
2008: Andreea M Bujor; Jaspreet Pannu; Shizhong Bu; Edwin A Smith; Robin C Muise-Helmericks; Maria Trojanowska
Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts.
The Journal of investigative dermatology 2008;128(8):1906-14.
2008: Arnold E Postlethwaite; Weng Kee Wong; Philip Clements; Soumya Chatterjee; Barri J Fessler; Andrew H Kang; Joseph Korn; MD Mayes; Peter A Merkel; Jerry A Molitor; Larry Moreland; Naomi Rothfield; Robert W Simms; Edwin A Smith; Robert Spiera; Virginia Steen; Kenneth Warrington; Barbara A White; Fredrick M Wigley; Daniel E Furst
A multicenter, randomized, double-blind, placebo-controlled trial of oral type I collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. oral type I collagen does not improve skin in all patients, but may improve skin in late-phase disease.
Arthritis and rheumatism 2008;58(6):1810-22.
2008: Laura B Hughes; Dahliann Morrison; James M Kelley; Miguel A Padilla; Laura Kelly Vaughan; Andrew Westfall; Harshit Dwivedi; Ted R Mikuls; V Michael Holers; Lezlie A Parrish; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Gary S Gilkeson; George Howard; Larry W Moreland; Nick Patterson; David Reich; S Louis Bridges
The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture.
Arthritis and rheumatism 2008;58(2):349-58.
2008: Charlton B. Strange; Marcy B Bolster; Michael D Roth; Richard M Silver; Arthur Theodore; Jonathan G Goldin; Philip Clements; Joanie Chung; Robert Elashoff; Robert Suh; Edwin A Smith; Daniel E Furst; Donald P Tashkin
Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease.
American journal of respiratory and critical care medicine 2008;177(1):91-8.
2007: Ashley D. Beall; Paul Nietert; Marian H Taylor; Holly C Mitchell; Stephanie R Shaftman; Richard M Silver; Edwin A Smith; Marcy B Bolster
Ethnic disparities among patients with pulmonary hypertension associated with systemic sclerosis.
The Journal of rheumatology 2007;34(6):1277-82.
2007: Jaspreet Pannu; SASHIDHAR NAKERAKANTI; Edwin A Smith; Peter ten Dijke; Maria Trojanowska
Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.
The Journal of biological chemistry 2007;282(14):10405-13.
2006: Ted R Mikuls; V Michael Holers; Lezlie A Parrish; Kristine A Kuhn; Doyt L Conn; Gary S Gilkeson; Edwin A Smith; Diane L Kamen; Beth L Jonas; Leigh F Callahan; Graciela S Alarcón; George Howard; Larry W Moreland; S Louis Bridges
Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis.
Arthritis and rheumatism 2006;54(9):3057-9.
2006: Jaspreet Pannu; Humphrey Gardner; Jeffrey R Shearstone; Edwin A Smith; Maria Trojanowska
Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma.
Arthritis and rheumatism 2006;54(9):3011-21.
2006: Humphrey Gardner; Jeffrey R Shearstone; Raj Bandaru; Thomas Crowell; Matthew Lynes; Maria Trojanowska; Jaspreet Pannu; Edwin A Smith; Stefania Jablonska; Maria Blaszczyk; Filemon K Tan; MD Mayes
Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts.
Arthritis and rheumatism 2006;54(6):1961-73.
2005: Ted R Mikuls; Kenneth G Saag; Jeffrey Curtis; S Louis Bridges; Graciela S Alarcon; Andrew Westfall; S Sam Lim; Edwin A Smith; Beth L Jonas; Larry W Moreland
Prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: the impact of ethnic-specific normative data.
Journal of the National Medical Association 2005;97(8):1155-60.
2004: Jaspreet Pannu; Elizabeth Gore-Hyer; Masayoshi Yamanaka; Edwin A Smith; Semyon Rubinchik; Jian-Yun Dong; Stefania Jablonska; Maria Blaszczyk; Maria Trojanowska
An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma.
Arthritis and rheumatism 2004;50(5):1566-77.
2004: Margaret Markiewicz; Edwin A Smith; Semyon Rubinchik; Jian-Yun Dong; Maria Trojanowska; E C LeRoy
The 72-kilodalton IE-1 protein of human cytomegalovirus (HCMV) is a potent inducer of connective tissue growth factor (CTGF) in human dermal fibroblasts.
Clinical and experimental rheumatology 2004;22(3 Suppl 33):S31-4.
2003: Masahide Kubo; Joanna Czuwara-Ladykowska; Omar Moussa; Margaret Markiewicz; Edwin A Smith; Richard M Silver; Stefania Jablonska; Maria Blaszczyk; Dennis Watson; Maria Trojanowska
Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin.
The American journal of pathology 2003;163(2):571-81.
2003: Elizabeth Gore-Hyer; Jaspreet Pannu; Edwin A Smith; Gary Grotendorst; Maria Trojanowska
Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts.
Arthritis and rheumatism 2003;48(3):798-806.
2002: Madoka Sato; Daniel Shegogue; Elizabeth A Gore; Edwin A Smith; Paul J McDermott; Maria Trojanowska
Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts.
The Journal of investigative dermatology 2002;118(4):704-11.
2001: Susan J Middaugh; Jennifer Haythornthwaite; Bruce Thompson; R Hill; K M Brown; Robert R Freedman; V Attanasio; Rolfe G Jacob; M Scheier; Edwin A Smith
The Raynaud's Treatment Study: biofeedback protocols and acquisition of temperature biofeedback skills.
Applied psychophysiology and biofeedback 2001;26(4):251-78.
2001: Joanna Czuwara-Ladykowska; Elizabeth A Gore; Daniel Shegogue; Edwin A Smith; Maria Trojanowska
Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts.
The British journal of dermatology 2001;145(4):569-75.
2001: Joanna Czuwara-Ladykowska; B Makiela; Edwin A Smith; Maria Trojanowska; Lidia Rudnicka
The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis.
Arthritis research 2001;3(5):311-8.
2000: Hildegard R Maricq; J R Jennings; I Valter; M Frederick; Bruce Thompson; Edwin A Smith; R Hill
Evaluation of treatment efficacy of Raynaud phenomenon by digital blood pressure response to cooling. Raynaud's Treatment Study Investigators.
Vascular medicine (London, England) 2000;5(3):135-40.
1999: Bruce Thompson; N L Geller; Sally Hunsberger; M Frederick; R Hill; Rolfe G Jacob; Edwin A Smith; P Kaufmann; Robert R Freedman; Fredrick M Wigley; Leonard Bielory
Behavioral and pharmacologic interventions: the Raynaud's Treatment Study.
Controlled clinical trials 1999;20(1):52-63.
1998: T Kawakami; H Ihn; W Xu; Edwin A Smith; C LeRoy; Maria Trojanowska
Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype.
The Journal of investigative dermatology 1998;110(1):47-51.
1997: Mark Ward; Joel K Curé; SI Schabel; Edwin A Smith; H Ralph Schumacher; Richard M Silver
Symptomatic spinal calcinosis in systemic sclerosis (scleroderma).
Arthritis and rheumatism 1997;40(10):1892-5.
1997: Y Ichiki; Edwin A Smith; E C LeRoy; Maria Trojanowska
Basic fibroblast growth factor inhibits basal and transforming growth factor-beta induced collagen alpha 2(I) gene expression in scleroderma and normal fibroblasts.
The Journal of rheumatology 1997;24(1):90-5.
1996: H A Makhluf; J Stepniakowska; Stanley Hoffman; Edwin A Smith; E C LeRoy; Maria Trojanowska
IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts.
The Journal of investigative dermatology 1996;107(6):856-9.
1996: C W Legerton; Edwin A Smith
Case management study: Raynaud's phenomenon.
Bulletin on the rheumatic diseases 1996;45(7):6-8.
1996: Frank C Arnett; John D Reveille; R Goldstein; K M Pollard; K Leaird; Edwin A Smith; E C Leroy; M J Fritzler
Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis.
Arthritis and rheumatism 1996;39(7):1151-60.
1996: RP Polisson; Gary S Gilkeson; E H Pyun; D S Pisetsky; Edwin A Smith; Lee S Simon
A multicenter trial of recombinant human interferon gamma in patients with systemic sclerosis: effects on cutaneous fibrosis and interleukin 2 receptor levels.
The Journal of rheumatology 1996;23(4):654-8.
1995: A Ludwicka; T Ohba; Maria Trojanowska; A Yamakage; Charlton B. Strange; Edwin A Smith; E C Leroy; S Sutherland; Richard M Silver
Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma.
The Journal of rheumatology 1995;22(10):1876-83.
1995: C W Legerton; Edwin A Smith; Richard M Silver
Systemic sclerosis (scleroderma). Clinical management of its major complications.
Rheumatic diseases clinics of North America 1995;21(1):203-16.
1995: Y Ichiki; Edwin A Smith; E C LeRoy; Maria Trojanowska
Different effects of basic fibroblast growth factor and transforming growth factor-beta on the two platelet-derived growth factor receptors' expression in scleroderma and healthy human dermal fibroblasts.
The Journal of investigative dermatology 1995;104(1):124-7.
1994: M Lubinus; Kathryn E Meier; Edwin A Smith; K C Gause; E C LeRoy; Maria Trojanowska
Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts.
The Journal of biological chemistry 1994;269(13):9822-5.
1993: S R Feldman; Maria Trojanowska; Edwin A Smith; E C Leroy
Differential responses of human papillary and reticular fibroblasts to growth factors.
The American journal of the medical sciences 1993;305(4):203-7.
1992: Edwin A Smith
Connective tissue metabolism including cytokines in scleroderma.
Current opinion in rheumatology 1992;4(6):869-77.
1992: A Ludwicka; Maria Trojanowska; Edwin A Smith; M Baumann; Charlton B. Strange; J H Korn; T Smith; E C Leroy; Richard M Silver
Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma.
The Journal of rheumatology 1992;19(11):1716-23.
1992: Richard M Silver; K McKinley; Edwin A Smith; B Quearry; Yadollah Harati; E M Sternberg; M P Heyes
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
Arthritis and rheumatism 1992;35(9):1097-105.
1992: K Kikuchi; C W Hartl; Edwin A Smith; E C LeRoy; Maria Trojanowska
Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation.
Biochemical and biophysical research communications 1992;187(1):45-50.
1992: K Kikuchi; A Yamakage; Edwin A Smith; E C LeRoy; Maria Trojanowska
Differential modulation of bFGF receptors by TGF-beta in adult skin, scleroderma skin, and newborn foreskin fibroblasts.
The Journal of investigative dermatology 1992;99(2):201-5.
1992: A Yamakage; K Kikuchi; Edwin A Smith; E C LeRoy; Maria Trojanowska
Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.
The Journal of experimental medicine 1992;175(5):1227-34.
1991: E C LeRoy; Maria Trojanowska; Edwin A Smith
The pathogenesis of scleroderma (systemic sclerosis, SSc).
Clinical and experimental rheumatology 1991;9(2):173-7.
1991: W D Xu; E C Leroy; Edwin A Smith
Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-beta.
The Journal of rheumatology 1991;18(2):241-6.
1990: Edwin A Smith; E C LeRoy
A possible role for transforming growth factor-beta in systemic sclerosis.
The Journal of investigative dermatology 1990;95(6 Suppl):125S-127S.
1990: E C LeRoy; Maria Trojanowska; Edwin A Smith
Cytokines and human fibrosis.
European cytokine network 1990;1(4):215-9.
1990: Hildegard R Maricq; A R McGregor; F Diat; Edwin A Smith; D B Maxwell; E C LeRoy; Martin C Weinrich
Major clinical diagnoses found among patients with Raynaud phenomenon from the general population.
The Journal of rheumatology 1990;17(9):1171-6.
1990: Richard M Silver; K S Miller; M B Kinsella; Edwin A Smith; SI Schabel
Evaluation and management of scleroderma lung disease using bronchoalveolar lavage.
The American journal of medicine 1990;88(5):470-6.
1990: K S Miller; Edwin A Smith; M Kinsella; SI Schabel; Richard M Silver
Lung disease associated with progressive systemic sclerosis. Assessment of interlobar variation by bronchoalveolar lavage and comparison with noninvasive evaluation of disease activity.
The American review of respiratory disease 1990;141(2):301-6.
1989: Hildegard R Maricq; Martin C Weinrich; J E Keil; Edwin A Smith; F E Harper; A I Nussbaum; E C LeRoy; A R McGregor; F Diat; E J Rosal
Prevalence of scleroderma spectrum disorders in the general population of South Carolina.
Arthritis and rheumatism 1989;32(8):998-1006.
1989: E C Leroy; Edwin A Smith; M Bashar Kahaleh; Maria Trojanowska; Richard M Silver
A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer?
Arthritis and rheumatism 1989;32(7):817-25.
1989: M B Kinsella; Edwin A Smith; K S Miller; E C LeRoy; Richard M Silver
Spontaneous production of fibronectin by alveolar macrophages in patients with scleroderma.
Arthritis and rheumatism 1989;32(5):577-83.
1988: M Bashar Kahaleh; Edwin A Smith; Y Soma; E C LeRoy
Effect of lymphotoxin and tumor necrosis factor on endothelial and connective tissue cell growth and function.
Clinical immunology and immunopathology 1988;49(2):261-72.
1986: M B Kahaleh; G L Sultany; Edwin A Smith; J E Huffstutter; C B Loadholt; E C LeRoy
A modified scleroderma skin scoring method.
Clinical and experimental rheumatology 1986;4(4):367-9.
1986: Edwin A Smith; M B Kahaleh; E C LeRoy
The acute phase response in scleroderma. Differing responses to intravenous PGE1.
Clinical and experimental rheumatology 1986;4(4):341-5.
1985: J S Mohrland; J M Porter; Edwin A Smith; J Belch; M H Simms
A multiclinic, placebo-controlled, double-blind study of prostaglandin E1 in Raynaud's syndrome.
Annals of the rheumatic diseases 1985;44(11):754-60.
1985: Edwin A Smith; F E Harper; E C LeRoy
Raynaud's phenomenon of a single digit following local intradermal bleomycin sulfate injection.
Arthritis and rheumatism 1985;28(4):459-61.