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Forrest Smith

Research Profile

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Injections, Intraventricular

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TOP 3
Annie Y Lam; Kitty Anderson; Soo Borson; Forrest L Smith
A pilot study to assess cognition and pillbox fill accuracy by community-dwelling older adults.
Bichoy Gabra; Chris P Bailey; Eamonn Kelly; Forrest L Smith; Graeme Henderson; William L Dewey
Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice.
Bichoy Gabra; Forrest L Smith; Hernán A Navarro; Frank carroll; William L Dewey
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.

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All Publications

2011: Annie Y Lam; Kitty Anderson; Soo Borson; Forrest L Smith
A pilot study to assess cognition and pillbox fill accuracy by community-dwelling older adults.
The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 2011;26(4):256-63.
2008: Bichoy Gabra; Chris P Bailey; Eamonn Kelly; Forrest L Smith; Graeme Henderson; William L Dewey
Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice.
Brain research 2008;1217():70-7.
2008: Bichoy Gabra; Forrest L Smith; Hernán A Navarro; Frank carroll; William L Dewey
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Brain research 2008;1187():58-66.
2007: Laura J Sim-Selley; K L Scoggins; Michael P Cassidy; L A Smith; William L Dewey; Forrest L Smith; Dana E Selley
Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance.
British journal of pharmacology 2007;151(8):1324-33.
2007: Bichoy Gabra; Chris P Bailey; Eamonn Kelly; Amanda V Sanders; Graeme Henderson; Forrest L Smith; William L Dewey
Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance.
Brain research 2007;1159():86-93.
2007: Frank carroll; Sharadsrikar Kotturi; Hernán A Navarro; Wayne Mascarella; Brian P Gilmour; Forrest L Smith; Bichoy Gabra; William L Dewey
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Journal of medicinal chemistry 2007;50(14):3388-91.
2007: Bichoy Gabra; Fay K Kessler; Joseph K Ritter; William L Dewey; Forrest L Smith
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia.
The Journal of pharmacology and experimental therapeutics 2007;322(1):186-94.
2007: Forrest L Smith; Raymond J Lindsay
Enhancement of bupivacaine local anesthesia with the potassium channel blocker ibutilide.
European journal of pain (London, England) 2007;11(5):551-6.
2007: Dawn C Stoller; Laura J Sim-Selley; Forrest L Smith
Role of kappa and delta opioid receptors in mediating morphine-induced antinociception in morphine-tolerant infant rats.
Brain research 2007;1142():28-36.
2007: Forrest L Smith; Bichoy Gabra; Paul A Smith; Marcia C Redwood; William L Dewey
Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice.
Pain 2007;127(1-2):129-39.
2006: Forrest L Smith; Ruby R Javed; Paul A Smith; William L Dewey; Bichoy Gabra
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;54(6):474-80.
2006: Chris P Bailey; Forrest L Smith; Eamonn Kelly; William L Dewey; Graeme Henderson
How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?
Trends in pharmacological sciences 2006;27(11):558-65.
2006: Billy R Martin; Jenny L Wiley; Irina P Beletskaya; Laura J Sim-Selley; Forrest L Smith; William L Dewey; Jean Cottney; Julia Adams; James Baker; David Hill; Bijali Saha; John Zerkowski; Anu Mahadevan; Raj K Razdan
Pharmacological characterization of novel water-soluble cannabinoids.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1230-9.
2005: Diana L Cichewicz; Sandra P Welch; Forrest L Smith
Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal delta9-tetrahydrocannabinol.
European journal of pharmacology 2005;525(1-3):74-82.
2005: George D Dalton; Forrest L Smith; Paul A Smith; William L Dewey
Protein Kinase A activity is increased in mouse lumbar spinal cord but not brain following morphine antinociceptive tolerance for 15 days.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;52(3):204-10.
2005: George D Dalton; Forrest L Smith; Paul A Smith; William L Dewey
Chronic Delta9-tetrahydrocannabinol treatment produces antinociceptive tolerance in mice without altering protein kinase A activity in mouse brain and spinal cord.
Biochemical pharmacology 2005;70(1):152-60.
2005: George D Dalton; Forrest L Smith; Paul A Smith; William L Dewey
Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).
Neuropharmacology 2005;48(5):648-57.
2005: Jenny L Wiley; Forrest L Smith; Raj K Razdan; William L Dewey
Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice.
European journal of pharmacology 2005;510(1-2):59-68.
2004: Dawn C Stoller; Forrest L Smith
Buprenorphine blocks withdrawal in morphine-dependent rat pups.
Paediatric anaesthesia 2004;14(8):642-9.
2004: Ruby R Javed; William L Dewey; Paul A Smith; Forrest L Smith
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice.
European journal of pharmacology 2004;492(2-3):149-57.
2004: Forrest L Smith; Paul A Smith; William L Dewey; Ruby R Javed
Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice.
European journal of pharmacology 2004;492(2-3):137-42.
2004: Forrest L Smith; Scott J LeBlanc; Richard Carter
Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.
European journal of pain (London, England) 2004;8(2):153-61.
2003: Forrest L Smith; Ruby R Javed; Mark J Elzey; William L Dewey
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.
Brain research 2003;985(1):78-88.
2003: Matthew C Lee; Forrest L Smith; David L Stevens; Sandra P Welch
The role of several kinases in mice tolerant to delta 9-tetrahydrocannabinol.
The Journal of pharmacology and experimental therapeutics 2003;305(2):593-9.
2003: Forrest L Smith; Raymond J Lindsay
Paradoxical enhancement of bupivacaine anesthesia in mice by drugs that open sodium channels.
Pharmacology 2003;67(2):90-8.
2002: Forrest L Smith; Ruby R Javed; Mark J Elzey; Sandra P Welch; Dana E Selley; Laura J Sim-Selley; William L Dewey
Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors.
Brain research 2002;958(1):28-35.
2002: Dawn C Stoller; Suzanne R Thornton; Forrest L Smith
Loss of antinociceptive efficacy in rat pups infused with morphine from osmotic minipumps.
Pharmacology 2002;66(1):11-8.
2001: Forrest L Smith; R W Davis; R Carter
Influence of Voltage-sensitive Ca(++) channel drugs on bupivacaine infiltration anesthesia in mice.
Anesthesiology 2001;95(5):1189-97.
2001: Anne Stiene-Martin; Pamela E Knapp; K Martin; Julie A Gurwell; S Ryan; Suzanne R Thornton; Forrest L Smith; Kurt F Hauser
Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo.
Glia 2001;36(1):78-88.
2001: AB Lohmann; Forrest L Smith
Buprenorphine substitution ameliorates spontaneous withdrawal in fentanyl-dependent rat pups.
Pediatric research 2001;49(1):50-5.
2000: C H Choe; Forrest L Smith
Sedative tolerance accompanies tolerance to the analgesic effects of fentanyl in infant rats.
Pediatric research 2000;47(6):727-35.
2000: Suzanne R Thornton; AB Lohmann; R A Nicholson; Forrest L Smith
Fentanyl self-administration in juvenile rats that were tolerant and dependent to fentanyl as infants.
Pharmacology, biochemistry, and behavior 2000;65(3):563-70.
1999: Forrest L Smith; AB Lohmann; William L Dewey
Involvement of phospholipid signal transduction pathways in morphine tolerance in mice.
British journal of pharmacology 1999;128(1):220-6.
1999: Diana L Cichewicz; Zachary L Martin; Forrest L Smith; Sandra P Welch
Enhancement mu opioid antinociception by oral delta9-tetrahydrocannabinol: dose-response analysis and receptor identification.
The Journal of pharmacology and experimental therapeutics 1999;289(2):859-67.
1999: Forrest L Smith; D S Dombrowski; William L Dewey
Involvement of intracellular calcium in morphine tolerance in mice.
Pharmacology, biochemistry, and behavior 1999;62(2):381-8.
1998: Suzanne R Thornton; Forrest L Smith
Long-term alterations in opiate antinociception resulting from infant fentanyl tolerance and dependence.
European journal of pharmacology 1998;363(2-3):113-9.
1998: Forrest L Smith; Diana L Cichewicz; Zachary L Martin; Sandra P Welch
The enhancement of morphine antinociception in mice by delta9-tetrahydrocannabinol.
Pharmacology, biochemistry, and behavior 1998;60(2):559-66.
1998: Forrest L Smith; K Fujimori; J Lowe; Sandra P Welch
Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats.
Pharmacology, biochemistry, and behavior 1998;60(1):183-91.
1998: Suzanne R Thornton; DR Compton; Forrest L Smith
Ontogeny of mu opioid agonist anti-nociception in postnatal rats.
Brain research. Developmental brain research 1998;105(2):269-76.
1997: Suzanne R Thornton; A F Wang; Forrest L Smith
Characterization of neonatal rat morphine tolerance and dependence.
European journal of pharmacology 1997;340(2-3):161-7.
1997: Sandra P Welch; Forrest L Smith; William L Dewey
Morphine tolerance-induced modulation of [3H]glyburide binding to mouse brain and spinal cord.
Drug and alcohol dependence 1997;45(1-2):47-53.
1997: Suzanne R Thornton; Forrest L Smith
Characterization of neonatal rat fentanyl tolerance and dependence.
The Journal of pharmacology and experimental therapeutics 1997;281(1):514-21.
1997: Forrest L Smith
Regional cutaneous differences in the duration of bupivacaine local anesthesia in mice.
Life sciences 1997;60(18):1613-21.
1995: Forrest L Smith; D L Stevens
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
The Journal of pharmacology and experimental therapeutics 1995;272(1):290-9.
1994: Forrest L Smith; D A Brase; D S Dombrowski; William L Dewey
Endogenous opioids released by suspending mice by the tail selectively enhance spinal mu opioid analgesia.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1177-85.
1994: M A Saxen; Forrest L Smith; L D Dunlow; D S Dombrowski; Sandra P Welch
The hypothermic and antinociceptive effects of intrathecal injection of CGRP (8-37) in mice.
Life sciences 1994;55(21):1665-74.
1993: Aron H Lichtman; Forrest L Smith; Billy R Martin
Evidence that the antinociceptive tail-flick response is produced independently from changes in either tail-skin temperature or core temperature.
Pain 1993;55(3):283-95.
1993: Forrest L Smith; Sandra P Welch; D S Dombrowski; William L Dewey
The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1407-15.
1993: Forrest L Smith; William L Dewey
Endogenous dynorphin modulates calcium-mediated antinociception in mice.
Pharmacology, biochemistry, and behavior 1993;45(2):383-91.
1992: Forrest L Smith; William L Dewey
Evidence that endogenous opioids mediate the antinociceptive effects of intrathecally administered calcium in mice.
The Journal of pharmacology and experimental therapeutics 1992;262(3):995-1003.