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Harold Smith

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William M McDougall; Harold C Smith
Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity.
Harold C Smith
APOBEC3G: a double agent in defense.
Chad A Galloway; John Ashton; Janet D Sparks; Robert A Mooney; Harold C Smith
Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.

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All Publications

2011: William M McDougall; Harold C Smith
Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity.
Biochemical and biophysical research communications 2011;412(4):612-7.
2011: Harold C Smith
APOBEC3G: a double agent in defense.
Trends in biochemical sciences 2011;36(5):239-44.
2010: Chad A Galloway; John Ashton; Janet D Sparks; Robert A Mooney; Harold C Smith
Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.
Biochimica et biophysica acta 2010;1802(11):976-85.
2010: Chad A Galloway; A Kumar; Jolanta Krucinska; Harold C Smith
APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers.
Biochemical and biophysical research communications 2010;398(1):38-43.
2010: Chad A Galloway; Harold C Smith
The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells.
Biochemical and biophysical research communications 2010;391(1):659-63.
2009: Jason D Salter; Jolanta Krucinska; Jay Raina; Harold C Smith; Joseph E Wedekind
A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function.
Biochemistry 2009;48(45):10685-7.
2008: Ryan P Bennett; Jason D Salter; Xiang Liu; Joseph E Wedekind; Harold C Smith
APOBEC3G subunits self-associate via the C-terminal deaminase domain.
The Journal of biological chemistry 2008;283(48):33329-36.
2007: David M Lehmann; Chad A Galloway; Celeste MacElrevey; Mark P Sowden; Joseph E Wedekind; Harold C Smith
Functional characterization of APOBEC-1 complementation factor phosphorylation sites.
Biochimica et biophysica acta 2007;1773(3):408-18.
2007: Harold C Smith
Measuring editing activity and identifying cytidine-to-uridine mRNA editing factors in cells and biochemical isolates.
Methods in enzymology 2007;424():389-416.
2006: Joseph E Wedekind; Richard E Gillilan; Alena Janda; Jolanta Krucinska; Jason Salter; Ryan P Bennett; Jay Raina; Harold C Smith
Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits.
The Journal of biological chemistry 2006;281(50):38122-6.
2006: Ryan P Bennett; Elie Diner; Mark P Sowden; Joshua A Lees; Joseph E Wedekind; Harold C Smith
APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic.
Biochemical and biophysical research communications 2006;350(1):214-9.
2006: H Travis Ichikawa; Mark P Sowden; Andrew T Torelli; Jürgen Bachl; Pinwei Huang; Geoff Dance; Shauna Marr; Jacques Robert; Joseph E Wedekind; Harold C Smith; Andrea Bottaro
Structural phylogenetic analysis of activation-induced deaminase function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):355-61.
2006: David M Lehmann; Chad A Galloway; Mark P Sowden; Harold C Smith
Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor.
Nucleic acids research 2006;34(11):3299-308.
2004: Harold C Smith; Andrea Bottaro; Mark P Sowden; Joseph E Wedekind
Activation induced deaminase: the importance of being specific.
Trends in genetics : TIG 2004;20(6):224-7.
2004: Kefang Xie; Mark P Sowden; Geoff Dance; Andrew T Torelli; Harold C Smith; Joseph E Wedekind
The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8114-9.
2004: Mark P Sowden; David M Lehmann; Xiaoyan Lin; Charles O Smith; Harold C Smith
Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing.
The Journal of biological chemistry 2004;279(1):197-206.
2003: Joseph E Wedekind; Geoff Dance; Mark P Sowden; Harold C Smith
Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.
Trends in genetics : TIG 2003;19(4):207-16.
2003: Chad A Galloway; Mark P Sowden; Harold C Smith
Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase.
BioTechniques 2003;34(3):524-6, 528, 530.
2002: Geoff Dance; Mark P Sowden; Luca Cartegni; Ellen Cooper; Adrian R Krainer; Harold C Smith
Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing.
The Journal of biological chemistry 2002;277(15):12703-9.
2002: Mark P Sowden; Nazzareno Ballatori; Karen L de Mesy Jensen; Lakesha Hamilton Reed; Harold C Smith
The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors.
Journal of cell science 2002;115(Pt 5):1027-39.
2002: Yan Yang; Nazzareno Ballatori; Harold C Smith
Apolipoprotein B mRNA editing and the reduction in synthesis and secretion of the atherogenic risk factor, apolipoprotein B100 can be effectively targeted through TAT-mediated protein transduction.
Molecular pharmacology 2002;61(2):269-76.
2001: A Giangreco; Mark P Sowden; I Mikityansky; Harold C Smith
Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis.
Biochemical and biophysical research communications 2001;289(5):1162-7.
2001: Mark P Sowden; Harold C Smith
Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.
The Biochemical journal 2001;359(Pt 3):697-705.
2001: Y Yang; Mark P Sowden; Y Yang; Harold C Smith
Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA.
Experimental cell research 2001;267(2):153-64.
2001: Geoff Dance; P Beemiller; Y Yang; D V Mater; I S Mian; Harold C Smith
Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.
Nucleic acids research 2001;29(8):1772-80.
2000: Y Yang; Mark P Sowden; Harold C Smith
Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1.
The Journal of biological chemistry 2000;275(30):22663-9.
2000: Geoff Dance; Mark P Sowden; Y Yang; Harold C Smith
APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.
Nucleic acids research 2000;28(2):424-9.
1999: J F Siddiqui; D Van Mater; Mark P Sowden; Harold C Smith
Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity.
Experimental cell research 1999;252(1):154-64.
1999: M F Steinburg; D Schock; J W Backus; Harold C Smith
Tissue-specific differences in the role of RNA 3' of the apolipoprotein B mRNA mooring sequence in editosome assembly.
Biochemical and biophysical research communications 1999;263(1):81-6.
1999: Mark P Sowden; Heidi L Collins; Harold C Smith; Timothy A Garrow; Janet D Sparks; Charles E Sparks
Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.
The Biochemical journal 1999;341 ( Pt 3)():639-45.
1998: D Van Mater; Mark P Sowden; Joanne Cianci; Janet D Sparks; Charles E Sparks; Nazzareno Ballatori; Harold C Smith
Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells.
Biochemical and biophysical research communications 1998;252(2):334-9.
1998: Harold C Smith
Analysis of protein complexes assembled on apolipoprotein B mRNA for mooring sequence-dependent RNA editing.
Methods (San Diego, Calif.) 1998;15(1):27-39.
1998: Mark P Sowden; Matthew J Eagleton; Harold C Smith
Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing.
Nucleic acids research 1998;26(7):1644-52.
1998: J Stewart; P Kozlowski; Mark P Sowden; E Messing; Harold C Smith
A quantitative assay for assessing allelic proportions by iterative gap ligation.
Nucleic acids research 1998;26(4):961-6.
1997: Y Yang; Y Yang; Harold C Smith
Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13075-80.
1997: Y Yang; Y Yang; K Kovalski; Harold C Smith
Partial characterization of the auxiliary factors involved in apolipoprotein B mRNA editing through APOBEC-1 affinity chromatography.
The Journal of biological chemistry 1997;272(44):27700-6.
1997: Harold C Smith; J M Gott; M R Hanson
A guide to RNA editing.
RNA (New York, N.Y.) 1997;3(10):1105-23.
1997: Janet D Sparks; Heidi L Collins; I Sabio; Mark P Sowden; Harold C Smith; Joanne Cianci; Charles E Sparks
Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells.
Biochimica et biophysica acta 1997;1347(1):51-61.
1996: Harold C Smith; Mark P Sowden
Base-modification mRNA editing through deamination--the good, the bad and the unregulated.
Trends in genetics : TIG 1996;12(10):418-24.
1996: Thuy L Phung; Mark P Sowden; Janet D Sparks; Charles E Sparks; Harold C Smith
Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat.
Metabolism: clinical and experimental 1996;45(9):1056-8.
1996: Mark P Sowden; J K Hamm; Sherry L Spinelli; Harold C Smith
Determinants involved in regulating the proportion of edited apolipoprotein B RNAs.
RNA (New York, N.Y.) 1996;2(3):274-88.
1996: Mark P Sowden; J K Hamm; Harold C Smith
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
The Journal of biological chemistry 1996;271(6):3011-7.
1996: D Schock; S R Kuo; M F Steinburg; M Bolognino; Janet D Sparks; Charles E Sparks; Harold C Smith
An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1097-102.
1996: Gary R Skuse; Amedeo Cappione; Mark P Sowden; Linda Metheny-Barlow; Harold C Smith
The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing.
Nucleic acids research 1996;24(3):478-85.
1996: Y Yang; Harold C Smith
In vitro reconstitution of apolipoprotein B RNA editing activity from recombinant APOBEC-1 and McArdle cell extracts.
Biochemical and biophysical research communications 1996;218(3):797-801.
1994: J W Backus; D Schock; Harold C Smith
Only cytidines 5' of the apolipoprotein B mRNA mooring sequence are edited.
Biochimica et biophysica acta 1994;1219(1):1-14.
1994: J W Backus; Harold C Smith
Specific 3' sequences flanking a minimal apolipoprotein B (apoB) mRNA editing 'cassette' are critical for efficient editing in vitro.
Biochimica et biophysica acta 1994;1217(1):65-73.
1993: C Barnes; Harold C Smith
Apolipoprotein B mRNA editing in vitro is a zinc-dependent process.
Biochemical and biophysical research communications 1993;197(3):1410-4.
1993: Harold C Smith
Apolipoprotein B mRNA editing: the sequence to the event.
Seminars in cell biology 1993;4(4):267-78.
1993: S G Harris; I Sabio; E Mayer; M F Steinberg; J W Backus; Janet D Sparks; Charles E Sparks; Harold C Smith
Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins.
The Journal of biological chemistry 1993;268(10):7382-92.
1992: J W Backus; Harold C Smith
Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro.
Nucleic acids research 1992;20(22):6007-14.
1992: Janet D Sparks; R Zolfaghari; Charles E Sparks; Harold C Smith; E A Fisher
Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats.
The Journal of clinical investigation 1992;89(5):1418-30.
1992: S G Harris; Harold C Smith
In vitro apolipoprotein B mRNA editing activity can be modulated by fasting and refeeding rats with a high carbohydrate diet.
Biochemical and biophysical research communications 1992;183(2):899-903.
1992: Harold C Smith
Organization of RNA splicing in the cell nucleus.
Current topics in cellular regulation 1992;33():145-66.
1991: J W Backus; Harold C Smith
Apolipoprotein B mRNA sequences 3' of the editing site are necessary and sufficient for editing and editosome assembly.
Nucleic acids research 1991;19(24):6781-6.
1991: Harold C Smith; S R Kuo; J W Backus; S G Harris; Charles E Sparks; Janet D Sparks
In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1489-93.
1990: J Boix; W J Habets; W J van Venrooij; Harold C Smith
Analysis of U1snRNP-specific A protein cross-linked complexes.
FEBS letters 1990;272(1-2):213-6.
1990: J W Backus; Matthew J Eagleton; S G Harris; Charles E Sparks; Janet D Sparks; Harold C Smith
Quantitation of endogenous liver apolipoprotein B mRNA editing.
Biochemical and biophysical research communications 1990;170(2):513-8.
1989: Harold C Smith; S G Harris; M Zillmann; Susan M Berget
Evidence that a nuclear matrix protein participates in premessenger RNA splicing.
Experimental cell research 1989;182(2):521-33.
1988: S G Harris; T E Martin; Harold C Smith
Reversible chemical cross-linking and ribonuclease digestion analysis of the organization of proteins in ribonucleoprotein particles.
Molecular and cellular biochemistry 1988;84(1):17-28.
1988: S G Harris; Sallie O Hoch; Harold C Smith
Chemical cross-linking of Sm and RNP antigenic proteins.
Biochemistry 1988;27(13):4595-600.
1988: S G Harris; Harold C Smith
SnRNP core protein enrichment in the nuclear matrix.
Biochemical and biophysical research communications 1988;152(3):1383-7.