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Maree Smith

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Pegah Varamini; Bruce D Wyse; Joanne T Blanchfield; Wei Huang Goh; Friederike M Mansfeld; Maree T Smith; Istvan Toth
Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation.
Kiran Shekar; Maree T Smith; Steven C Wallis; Sussan Ghassabian; Daniel V Mullany; Jason A Roberts; John F Fraser
Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?
Kiran Shekar; Maree T Smith; YL Fung; Jason A Roberts; John F Fraser
The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation.

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2013: Pegah Varamini; Bruce D Wyse; Joanne T Blanchfield; Wei Huang Goh; Friederike M Mansfeld; Maree T Smith; Istvan Toth
Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation.
Bioorganic & medicinal chemistry 2013;21(7):1898-904.
2013: Kiran Shekar; Maree T Smith; Steven C Wallis; Sussan Ghassabian; Daniel V Mullany; Jason A Roberts; John F Fraser
Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?
The Journal of antimicrobial chemotherapy 2013;68(3):726-7.
2013: Kiran Shekar; Maree T Smith; YL Fung; Jason A Roberts; John F Fraser
The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation.
BMC anesthesiology 2013;13():7.
2012: Kiran Shekar; Maree T Smith; John F Fraser; Jason A Roberts
Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation.
Journal of critical care 2012;27(6):741.e9-18.
2012: Sussan Ghassabian; Seyed Mojtaba Moosavi; Kiran Shekar; John F Fraser; Yarmarly Guerra Valero; Maree T Smith
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;903():126-33.
2012: Maree T Smith; Brendan J Moore
Pregabalin for the treatment of fibromyalgia.
Expert opinion on pharmacotherapy 2012;13(10):1527-33.
2012: Pegah Varamini; Bruce D Wyse; Joanne T Blanchfield; Friederike M Mansfeld; Maree T Smith; Istvan Toth
Synthesis and biological evaluation of an orally active glycosylated endomorphin-1.
Journal of medicinal chemistry 2012;55(12):5859-67.
2012: Kiran Shekar; Maree T Smith; Steven C Wallis; James Walsham; Susan Welch; Adrian G Barnett; Fay Burrows; Hergen Buscher; YL Fung; Sussan Ghassabian; Eileen Gilder; Bianca Levkovich; Shay McGuinness; Daniel V Mullany; Rachael Parke; Vin Pellegrino; Jason A Roberts; Sam Rudham; John F Fraser
ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO.
BMC anesthesiology 2012;12():29.
2012: Pegah Varamini; Bruce D Wyse; Joanne T Blanchfield; Friederike M Mansfeld; Maree T Smith; Istvan Toth
Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation.
PloS one 2012;7(8):e41909.
2011: Arjun Muralidharan; Maree T Smith
Pain, analgesia and genetics.
The Journal of pharmacy and pharmacology 2011;63(11):1387-400.
2011: Paul Gray; Julie Kirby; Maree T Smith; Peter J Cabot; Bronwyn Williams; James Doecke; Tess Cramond
Pregabalin in severe burn injury pain: a double-blind, randomised placebo-controlled trial.
Pain 2011;152(6):1279-88.
2011: Kathleen J Otto; Bruce D Wyse; Peter J Cabot; Maree T Smith
Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats.
Pain medicine (Malden, Mass.) 2011;12(5):782-93.
2011: Kathleen J Otto; Bruce D Wyse; Peter J Cabot; Maree T Smith
Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months.
Pain medicine (Malden, Mass.) 2011;12(3):437-50.
2010: Che S Zin; Lisa M Nissen; James P O'Callaghan; Stephen B Duffull; Maree T Smith; Brendan J Moore
A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin.
The journal of pain : official journal of the American Pain Society 2010;11(5):462-71.
2010: Che S Zin; Lisa M Nissen; James P O'Callaghan; Brendan J Moore; Maree T Smith
Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
Pain medicine (Malden, Mass.) 2010;11(4):550-61.
2009: Kamondanai Hemstapat; Loan Le; Stephen R Edwards; Maree T Smith
Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A(2-17) following spinal and supraspinal routes of administration.
Pharmacology, biochemistry, and behavior 2009;93(4):498-505.
2009: Samantha M South; Stephen R Edwards; Maree T Smith
Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-Dawley rats: differences between the tail flick and hot plate nociceptive tests.
Clinical and experimental pharmacology & physiology 2009;36(1):20-8.
2008: Maree T Smith
Differences between and combinations of opioids re-visited.
Current opinion in anaesthesiology 2008;21(5):596-601.
2008: Samuel Chan; Stephen R Edwards; Bruce D Wyse; Maree T Smith
Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat.
Clinical and experimental pharmacology & physiology 2008;35(3):295-302.
2008: Che S Zin; Lisa M Nissen; Maree T Smith; James P O'Callaghan; Brendan J Moore
An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy.
CNS drugs 2008;22(5):417-42.
2007: Carsten Nielsen; Fraser B Ross; Shahrdad Lotfipour; Kamal S Saini; Stephen R Edwards; Maree T Smith
Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain.
Pain 2007;132(3):289-300.
2007: Maree T Smith; Stephen R Edwards; Carsten Nielsen
Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration.
Anesthesiology 2007;106(5):1063-4; author reply 1064-5.
2007: Stephen R Edwards; Laurence E Mather; Maree T Smith
Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats.
Clinical and experimental pharmacology & physiology 2007;34(5-6):414-20.
2007: Stephen R Edwards; Maree T Smith
Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;848(2):264-70.
2005: Carsten Nielsen; Richard J Lewis; Dianne Alewood; Roger Drinkwater; Elka Palant; Margaret Patterson; Tony L Yaksh; Damon McCumber; Maree T Smith
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain.
Pain 2005;118(1-2):112-24.
2005: Lillian Huang; Stephen R Edwards; Maree T Smith
Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague--Dawley rats: influence of streptozotocin-induced diabetes.
Pharmaceutical research 2005;22(9):1489-98.
2005: Leigh A Ladd; P C Kam; Desmond Williams; Andrew W E Wright; Maree T Smith; Laurence E Mather
Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions.
British journal of clinical pharmacology 2005;59(5):524-35.
2005: Stephen R Edwards; Maree T Smith
Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;814(2):241-9.
2004: Kamondanai Hemstapat; Maree T Smith; Gregory Raymond Monteith
Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: potential application to biomolecular screening.
Journal of pharmacological and toxicological methods 2004;49(2):81-7.
2003: Kamondanai Hemstapat; Steven A Smith; Gregory Raymond Monteith; Maree T Smith
The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones.
Pharmacology & toxicology 2003;93(4):197-200.
2003: Kamondanai Hemstapat; Gregory Raymond Monteith; Deborah Smith; Maree T Smith
Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: mechanistic studies in embryonic cultured hippocampal neurones.
Anesthesia and analgesia 2003;97(2):494-505, table of contents.
2003: Michael Wei; Leslie Ong; Maree T Smith; Fraser B Ross; Katrina Schmid; Andrew J Hoey; Darryl J Burstow; Lindsay Brown
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.
Heart, lung & circulation 2003;12(1):44-50.
2002: Maree T Smith; Peter J Cabot; Fraser B Ross; Alan D Robertson; Richard J Lewis
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
Pain 2002;96(1-2):119-27.
2001: Lisa Nissen; Susan E Tett; Tess Cramond; B Williams; Maree T Smith
Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital.
British journal of clinical pharmacology 2001;52(6):693-8.
2001: Andrew W E Wright; Laurence E Mather; Maree T Smith
Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide.
Life sciences 2001;69(4):409-20.
2001: S M South; Andrew W E Wright; M Lau; Laurence E Mather; Maree T Smith
Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance.
The Journal of pharmacology and experimental therapeutics 2001;297(1):446-57.
2000: Carsten Nielsen; Fraser B Ross; Maree T Smith
Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat.
The Journal of pharmacology and experimental therapeutics 2000;295(1):91-9.
2000: Maree T Smith
Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites.
Clinical and experimental pharmacology & physiology 2000;27(7):524-8.
2000: Fraser B Ross; Steven C Wallis; Maree T Smith
Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats.
Pain 2000;84(2-3):421-8.
2000: Maree T Smith; Carsten Nielsen; M Y Lim-Fraser; Andrew W E Wright; M Lau
Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):236-44.
1999: HL Keates; Tess Cramond; Maree T Smith
Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis.
Anesthesia and analgesia 1999;89(2):409-15.
1999: A J Halliday; Selena Bartlett; P Colditz; Maree T Smith
Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide.
Life sciences 1999;65(2):225-36.
1999: Maree T Smith; Andrew W E Wright; B E Williams; G Stuart; Tess Cramond
Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management.
Anesthesia and analgesia 1999;88(1):109-16.
1998: S M South; Maree T Smith
Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1326-32.
1998: Andrew W E Wright; J A Lawrence; M Iu; Tess Cramond; Maree T Smith
Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma.
Journal of chromatography. B, Biomedical sciences and applications 1998;712(1-2):169-75.
1998: G D Smith; Maree T Smith
The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1157-62.
1998: Andrew W E Wright; Maree T Smith
Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection.
Therapeutic drug monitoring 1998;20(2):215-8.
1998: Andrew W E Wright; M L Nocente; Maree T Smith
Hydromorphone-3-glucuronide: biochemical synthesis and preliminary pharmacological evaluation.
Life sciences 1998;63(5):401-11.
1997: Fraser B Ross; Maree T Smith
The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated.
Pain 1997;73(2):151-7.
1997: Peter J Cabot; Tess Cramond; Maree T Smith
Morphine has a dual concentration-dependent effect on K(+)-evoked substance P release from rat peripheral airways.
Pulmonary pharmacology & therapeutics 1997;10(4):215-21.
1997: G D Smith; RJ Prankerd; Maree T Smith
Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide.
Life sciences 1997;61(2):95-104.
1996: P J Cabot; Tess Cramond; Maree T Smith
Quantitative autoradiography of peripheral opioid binding sites in rat lung.
European journal of pharmacology 1996;310(1):47-53.
1996: Selena Bartlett; Maree T Smith
Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [3H]-glutamic acid and [14C]-gamma-aminobutyric acid from rat brain synaptosomes.
Life sciences 1996;58(5):447-54.
1995: G D Smith; Maree T Smith
Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat.
Pain 1995;62(1):51-60.
1995: K P Leow; Tess Cramond; Maree T Smith
Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain.
Anesthesia and analgesia 1995;80(2):296-302.
1995: Selena Bartlett; Maree T Smith
The apparent affinity of morphine-3-glucuronide at mu1-opioid receptors results from morphine contamination: demonstration using HPLC and radioligand binding.
Life sciences 1995;57(6):609-15.
1994: Selena Bartlett; Peter R Dodd; Maree T Smith
Pharmacology of morphine and morphine-3-glucuronide at opioid, excitatory amino acid, GABA and glycine binding sites.
Pharmacology & toxicology 1994;75(2):73-81.
1994: P J Cabot; P R Dodd; Tess Cramond; Maree T Smith
Characterization of non-conventional opioid binding sites in rat and human lung.
European journal of pharmacology 1994;268(2):247-55.
1994: Andrew W E Wright; J A Watt; M Kennedy; Tess Cramond; Maree T Smith
Quantitation of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma and cerebrospinal fluid using solid-phase extraction and high-performance liquid chromatography with electrochemical detection.
Therapeutic drug monitoring 1994;16(2):200-8.
1994: K P Leow; Maree T Smith
The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats.
Life sciences 1994;54(17):1229-36.
1994: Selena Bartlett; Tess Cramond; Maree T Smith
The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex.
Life sciences 1994;54(10):687-94.
1993: K P Leow; Andrew W E Wright; Tess Cramond; Maree T Smith
Determination of the serum protein binding of oxycodone and morphine using ultrafiltration.
Therapeutic drug monitoring 1993;15(5):440-7.
1992: K P Leow; Maree T Smith; J A Watt; B E Williams; Tess Cramond
Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration.
Therapeutic drug monitoring 1992;14(6):479-84.
1992: K P Leow; Maree T Smith; B Williams; Tess Cramond
Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer.
Clinical pharmacology and therapeutics 1992;52(5):487-95.
1992: Tess Cramond; Maree T Smith; J A Watt
Comments on Gong et al., PAIN, 48 (1992) 249-255.
Pain 1992;51(1):124-5.
1991: Maree T Smith; J A Watt; G P Mapp; Tess Cramond
Quantitation of oxycodone in human plasma using high-performance liquid chromatography with electrochemical detection.
Therapeutic drug monitoring 1991;13(2):126-30.
1990: W S Cheng; T L Murphy; Maree T Smith; W G Cooksley; JW Halliday; Lawrie W Powell
Dose-dependent pharmacokinetics of caffeine in humans: relevance as a test of quantitative liver function.
Clinical pharmacology and therapeutics 1990;47(4):516-24.
1990: Maree T Smith; J A Watt; Tess Cramond
Morphine-3-glucuronide--a potent antagonist of morphine analgesia.
Life sciences 1990;47(6):579-85.