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Paul Smith

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Rachel J Errington; Victoria D Griesdoorn; Imtiaz A Khan; Nuria Márquez; Sally C Chappell; Marie Wiltshire; Paul J Smith
Time-lapse microscopy approaches to track cell cycle and lineage progression at the single-cell level.
Paul J Smith; Marie Wiltshire; Klaus Pors; Philip A Burns; Sally C Chappell; Laura Cosentino; Rachel J Errington
Kinetic analysis of intracellular Hoechst 33342--DNA interactions by flow cytometry: misinterpretation of side population status?
James A Tonkin; Martyn R Brown; Sally C Chappell; Rachel J Errington; Paul Rees; Paul J Smith; Huw D Summers
Automated cell identification and tracking using nanoparticle moving-light-displays.

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All Publications

2013: Rachel J Errington; Victoria D Griesdoorn; Imtiaz A Khan; Nuria Márquez; Sally C Chappell; Marie Wiltshire; Paul J Smith
Time-lapse microscopy approaches to track cell cycle and lineage progression at the single-cell level.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2013;Chapter 12():Unit12.4.
2013: Paul J Smith; Marie Wiltshire; Klaus Pors; Philip A Burns; Sally C Chappell; Laura Cosentino; Rachel J Errington
Kinetic analysis of intracellular Hoechst 33342--DNA interactions by flow cytometry: misinterpretation of side population status?
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2013;83(1):161-9.
2012: James A Tonkin; Martyn R Brown; Sally C Chappell; Rachel J Errington; Paul Rees; Paul J Smith; Huw D Summers
Automated cell identification and tracking using nanoparticle moving-light-displays.
PloS one 2012;7(7):e40835.
2011: M I Atari; Michael J Chappell; Rachel J Errington; Paul J Smith; Neil D Evans
Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport.
Computer methods and programs in biomedicine 2011;104(2):93-103.
2011: Thomas Fricke; Arwyn T Jones; Robert J Mart; Paul J Smith; Catherine L Watkins; Marie Wiltshire; Rachel J Errington; Rudolf K Allemann
Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins.
Bioconjugate chemistry 2011;22(9):1763-7.
2011: Luke C Davies; Donald J Fraser; Simon A Jones; Marcela Rosas; Paul J Smith; Philip R Taylor
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation.
European journal of immunology 2011;41(8):2155-64.
2011: Paul J Smith; Andreas Radbruch
Cyto 2011 - overview of the XXVI ISAC Congress Proceedings Issue of Cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(5):325-7.
2011: Imtiaz A Khan; Monica Lupi; Paul J Smith; Paolo Ubezio; Marie Wiltshire; M Rowan Brown; Lee Campbell; Sally C Chappell; Rachel J Errington
Interoperability of time series cytometric data: a cross platform approach for modeling tumor heterogeneity.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(3):214-26.
2011: Huw D Summers; Paul Rees; Mark D Holton; M Rowan Brown; Sally C Chappell; Paul J Smith; Rachel J Errington
Statistical analysis of nanoparticle dosing in a dynamic cellular system.
Nature nanotechnology 2011;6(3):170-4.
2011: Paul Rees; M Rowan Brown; Huw D Summers; Mark D Holton; Rachel J Errington; Sally C Chappell; Paul J Smith
A transfer function approach to measuring cell inheritance.
BMC systems biology 2011;5():31.
2010: M Rowan Brown; Huw D Summers; Paul Rees; Sally C Chappell; Oscar F Silvestre; Imtiaz A Khan; Paul J Smith; Rachel J Errington
Long-term time series analysis of quantum dot encoded cells by deconvolution of the autofluorescence signal.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(10):925-32.
2010: M Rowan Brown; Huw D Summers; Paul Rees; Paul J Smith; Sally C Chappell; Rachel J Errington
Flow-based cytometric analysis of cell cycle via simulated cell populations.
PLoS computational biology 2010;6(4):e1000741.
2010: Rachel J Errington; Martyn R Brown; Oscar F Silvestre; Kerenza L Njoh; Sally C Chappell; Imtiaz A Khan; Paul Rees; Steve P Wilks; Paul J Smith; Huw D Summers
Single cell nanoparticle tracking to model cell cycle dynamics and compartmental inheritance.
Cell cycle (Georgetown, Tex.) 2010;9(1):121-30.
2009: Paul J Smith; Emeline Furon; Marie Wiltshire; Lee Campbell; Graham P Feeney; Ronald D Snyder; Rachel J Errington
ABCG2-associated resistance to Hoechst 33342 and topotecan in a murine cell model with constitutive expression of side population characteristics.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(11):924-33.
2009: Paul J Smith; Imtiaz A Khan; Rachel J Errington
Cytomics and cellular informatics--coping with asymmetry and heterogeneity in biological systems.
Drug discovery today 2009;14(5-6):271-7.
2008: Michael J Chappell; Neil D Evans; Rachel J Errington; I A Khan; L Campbell; R Ali; Keith R Godfrey; Paul J Smith
A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan.
Computer methods and programs in biomedicine 2008;89(2):169-78.
2008: Paul J Smith; Suet-Feung Chin; Kerenza Njoh; Imtiaz A Khan; Michael J Chappell; Rachel J Errington
Cell cycle checkpoint-guarded routes to catenation-induced chromosomal instability.
SEB experimental biology series 2008;59():219-42.
2007: Jane A Bond; Andreas J Gescher; Richard D Verschoyle; Nick Lemoine; Rachel J Errington; Marie Wiltshire; Paul J Smith; David Wynford-Thomas
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2007;121(7):1445-54.
2007: Paul J Smith; Nuria Márquez; Marie Wiltshire; Sally C Chappell; Kerenza L Njoh; Lee Campbell; Imtiaz A Khan; Oscar Silvestre; Rachel J Errington
Mitotic bypass via an occult cell cycle phase following DNA topoisomerase II inhibition in p53 functional human tumor cells.
Cell cycle (Georgetown, Tex.) 2007;6(16):2071-81.
2007: Paul J Smith; I A Khan; Rachel J Errington
Cytomics and drug development.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(6):349-51.
2007: Imtiaz A Khan; Peter Husemann; Lee Campbell; Nick S White; Richard J White; Paul J Smith; Rachel J Errington
ProgeniDB: a novel cell lineage database for generation associated phenotypic behavior in cell-based assays.
Cell cycle (Georgetown, Tex.) 2007;6(7):868-74.
2007: E Z Chong; D R Matthews; H D Summers; Kerenza L Njoh; Rachel J Errington; Paul J Smith
Development of FRET-based assays in the far-red using CdTe quantum dots.
Journal of biomedicine & biotechnology 2007;2007(7):54169.
2006: Kerenza L Njoh; Laurence H Patterson; Mire Zloh; Marie Wiltshire; Janet Fisher; Sally C Chappell; Simon M Ameer-Beg; Yanhong Bai; Daniel Matthews; Rachel J Errington; Paul J Smith
Spectral analysis of the DNA targeting bisalkylaminoanthraquinone DRAQ5 in intact living cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(8):805-14.
2006: D R Matthews; H D Summers; Kerenza L Njoh; Rachel J Errington; Paul J Smith; Paul Richard Barber; Simon M Ameer-Beg; Borivoj Vojnovic
Technique for measurement of fluorescence lifetime by use of stroboscopic excitation and continuous-wave detection.
Applied optics 2006;45(9):2115-23.
2005: Klaus Pors; Jane A Plumb; Robert Brown; Paul Teesdale-Spittle; Mark Searcey; Paul J Smith; Laurence H Patterson
Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.
Journal of medicinal chemistry 2005;48(21):6690-5.
2005: F Al-Khafaji; Marie Wiltshire; Dagmar Führer; Gherardo Mazziotti; Mark D Lewis; Paul J Smith; Marian Ludgate
Biological activity of activating thyrotrophin receptor mutants: modulation by iodide.
Journal of molecular endocrinology 2005;34(1):209-20.
2005: Rachel J Errington; Simon M Ameer-Beg; Borivoj Vojnovic; Laurence H Patterson; Mire Zloh; Paul J Smith
Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells.
Advanced drug delivery reviews 2005;57(1):153-67.
2004: Neil D Evans; Rachel J Errington; Michael Shelley; Graham P Feeney; Michael J Chapman; Keith R Godfrey; Paul J Smith; Michael J Chappell
A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan.
Mathematical biosciences 2004;189(2):185-217.
2004: Paul J Smith; Marie Wiltshire; Rachel J Errington
DRAQ5 labeling of nuclear DNA in live and fixed cells.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.25.
2004: Nuria Márquez; Sally C Chappell; Owen J Sansom; Alan R Clarke; Paul Teesdale-Spittle; Rachel J Errington; Paul J Smith
Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts.
Cell cycle (Georgetown, Tex.) 2004;3(5):662-71.
2003: John P Malkinson; Mire Zloh; Mohanad Kadom; Rachel J Errington; Paul J Smith; Mark Searcey
Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions.
Organic letters 2003;5(26):5051-4.
2003: Nuria Márquez; Sally C Chappell; Owen J Sansom; Alan R Clarke; Jon Court; Rachel J Errington; Paul J Smith
Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint.
Oncogene 2003;22(48):7642-8.
2003: Graham P Feeney; Rachel J Errington; Marie Wiltshire; Nuria Márquez; Sally C Chappell; Paul J Smith
Tracking the cell cycle origins for escape from topotecan action by breast cancer cells.
British journal of cancer 2003;88(8):1310-7.
2003: Terence Davis; Sim K Singhrao; Fiona S Wyllie; Michèle F Haughton; Paul J Smith; Marie Wiltshire; David Wynford-Thomas; Christopher John Jones; Richard G A Faragher; David Kipling
Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.
Journal of cell science 2003;116(Pt 7):1349-57.
2002: Paul J Smith; Marie Wiltshire; Sharon Davies; Suet-Feung Chin; Anthony K Campbell; Rachel J Errington
DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells.
American journal of physiology. Cell physiology 2002;283(2):C609-22.
2002: D Aled Rees; Mark D Lewis; B Mary Lewis; Paul J Smith; Maurice F Scanlon; Jack Ham
Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors.
Endocrinology 2002;143(6):2427-36.
2001: Paul J Smith; Marie Wiltshire
Cytometry of antitumor drug-intracellular target interactions.
Methods in cell biology 2001;64():173-91.
2000: Paul J Smith; NJ Blunt; Marie Wiltshire; Terry Hoy; Paul Teesdale-Spittle; M R Craven; J V Watson; W B Amos; Rachel J Errington; Laurence H Patterson
Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy.
Cytometry 2000;40(4):280-91.
2000: Marie Wiltshire; Laurence H Patterson; Paul J Smith
A novel deep red/low infrared fluorescent flow cytometric probe, DRAQ5NO, for the discrimination of intact nucleated cells in apoptotic cell populations.
Cytometry 2000;39(3):217-23.
1999: Paul J Smith; Marie Wiltshire; S Davies; Laurence H Patterson; Terry Hoy
A novel cell permeant and far red-fluorescing DNA probe, DRAQ5, for blood cell discrimination by flow cytometry.
Journal of immunological methods 1999;229(1-2):131-9.
1999: Paul J Smith; Marie Wiltshire; Suet-Feung Chin; P Rabbitts; S Souès
Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small-cell lung carcinoma cells.
International journal of radiation biology 1999;75(9):1137-47.
1999: Jane A Bond; Michèle F Haughton; Jan Rowson; Paul J Smith; Véronique Gire; David Wynford-Thomas; Fiona S Wyllie
Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.
Molecular and cellular biology 1999;19(4):3103-14.
1997: Paul J Smith; NJ Blunt; R Desnoyers; Y Giles; Laurence H Patterson
DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides.
Cancer chemotherapy and pharmacology 1997;39(5):455-61.
1997: Paul J Smith; R Desnoyers; NJ Blunt; Y Giles; Laurence H Patterson; J V Watson
Flow cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells using 647-nm krypton laser excitation.
Cytometry 1997;27(1):43-53.
1995: M E Fox; Paul J Smith
Subcellular localisation of the antitumour drug mitoxantrone and the induction of DNA damage in resistant and sensitive human colon carcinoma cells.
Cancer chemotherapy and pharmacology 1995;35(5):403-10.
1994: Paul J Smith; S Souès; T Gottlieb; S J Falk; J V Watson; R J Osborne; N M Bleehen
Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.
British journal of cancer 1994;70(5):914-21.
1994: Paul J Smith; S Souès
Multilevel therapeutic targeting by topoisomerase inhibitors.
The British journal of cancer. Supplement 1994;23():S47-51.
1994: Paul J Smith; C Rackstraw; F Cotter
DNA fragmentation as a consequence of cell cycle traverse in doxorubicin- and idarubicin-treated human lymphoma cells.
Annals of hematology 1994;69 Suppl 1():S7-11.
1992: Paul J Smith; H R Sykes; M E Fox; I J Furlong
Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage.
Cancer research 1992;52(14):4000-8.
1992: S J Falk; Paul J Smith
DNA damaging and cell cycle effects of the topoisomerase I poison camptothecin in irradiated human cells.
International journal of radiation biology 1992;61(6):749-57.
1992: Paul J Smith; H R Sykes
Simultaneous measurement of cell cycle phase position and ionizing radiation-induced DNA strand breakage in single human tumour cells using laser scanning confocal imaging.
International journal of radiation biology 1992;61(4):553-60.
1991: Paul J Smith; S A Morgan; J V Watson
Detection of multidrug resistance and quantification of responses of human tumour cells to cytotoxic agents using flow cytometric spectral shift analysis of Hoechst 33,342-DNA fluorescence.
Cancer chemotherapy and pharmacology 1991;27(6):445-50.
1990: S A Morgan; J V Watson; P R Twentyman; Paul J Smith
Reduced nuclear binding of a DNA minor groove ligand (Hoechst 33342) and its impact on cytotoxicity in drug resistant murine cell lines.
British journal of cancer 1990;62(6):959-65.
1990: Paul J Smith; S A Morgan; M E Fox; J V Watson
Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells.
Biochemical pharmacology 1990;40(9):2069-78.
1990: Paul J Smith
DNA topoisomerases and radiation responses.
International journal of radiation biology 1990;58(4):553-9.
1990: Paul J Smith; S M Bell; A Dee; H Sykes
Involvement of DNA topoisomerase II in the selective resistance of a mammalian cell mutant to DNA minor groove ligands: ligand-induced DNA-protein crosslinking and responses to topoisomerase poisons.
Carcinogenesis 1990;11(4):659-65.
1989: S A Morgan; J V Watson; P R Twentyman; Paul J Smith
Flow cytometric analysis of Hoechst 33342 uptake as an indicator of multi-drug resistance in human lung cancer.
British journal of cancer 1989;60(3):282-7.
1989: Paul J Smith; P G Debenham; J V Watson
A role of DNA topoisomerases in the active dissociation of DNA minor groove-ligand complexes. A flow cytometric study of inhibitor effects.
Mutation research 1989;217(2):163-72.
1988: Paul J Smith; M Lacy; P G Debenham; J V Watson
A mammalian cell mutant with enhanced capacity to dissociate a bis-benzimidazole dye-DNA complex.
Carcinogenesis 1988;9(3):485-90.