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Robin Smith

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Carolyn M Porteous; Robin A J Smith; Franklin I Aigbirhio; David K Menon; Michael P Murphy
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain.
Geoffrey F Kelso; Angela Logan; Andrej Maroz; Michael P Murphy; Alexander V Peskin; Carolyn M Porteous; Tracy A Prime; Meredith F Ross; Robert F Anderson; Sally Brooker; Helena M Cochemé; Andrew M James; Christine C Winterbourn; Robin A J Smith
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.
Robin A J Smith; Helena M Cochemé; Richard C Hartley; Michael P Murphy
Mitochondrial pharmacology.

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All Publications

2013: Carolyn M Porteous; Robin A J Smith; Franklin I Aigbirhio; David K Menon; Michael P Murphy
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain.
Biochimica et biophysica acta 2013;1830(6):3458-65.
2012: Geoffrey F Kelso; Angela Logan; Andrej Maroz; Michael P Murphy; Alexander V Peskin; Carolyn M Porteous; Tracy A Prime; Meredith F Ross; Robert F Anderson; Sally Brooker; Helena M Cochemé; Andrew M James; Christine C Winterbourn; Robin A J Smith
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.
Chemistry & biology 2012;19(10):1237-46.
2012: Robin A J Smith; Helena M Cochemé; Richard C Hartley; Michael P Murphy
Mitochondrial pharmacology.
Trends in pharmacological sciences 2012;33(6):341-52.
2012: Helena M Cochemé; Ian M Fearnley; Richard C Hartley; Andrew M James; Angela Logan; Stephen J McQuaker; Linda Partridge; Jigna V Patel; Carolyn M Porteous; Tracy A Prime; Caroline Quin; Robin A J Smith; Irina Abakumova; Michael P Murphy
Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila.
Nature protocols 2012;7(5):946-58.
2011: Robin A J Smith; Richard C Hartley; Michael P Murphy
Mitochondria-targeted small molecule therapeutics and probes.
Antioxidants & redox signaling 2011;15(12):3021-38.
2011: Helena M Cochemé; Caroline Quin; Stephen J McQuaker; Filipe Cabreiro; Angela Logan; Tracy A Prime; Irina Abakumova; Jigna V Patel; Ian M Fearnley; Andrew M James; Carolyn M Porteous; Robin A J Smith; Saima Saeed; Jane E Carré; Mervyn Singer; David Gems; Richard C Hartley; Linda Partridge; Michael P Murphy
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.
Cell metabolism 2011;13(3):340-50.
2011: Robin A J Smith; Michael P Murphy
Mitochondria-targeted antioxidants as therapies.
Discovery medicine 2011;11(57):106-14.
2010: Carolyn M Porteous; Angela Logan; Cameron Evans; Elizabeth C Ledgerwood; David K Menon; Franklin Aigbirhio; Robin A J Smith; Michael P Murphy
Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes.
Biochimica et biophysica acta 2010;1800(9):1009-17.
2010: Robin A J Smith; Michael P Murphy
Animal and human studies with the mitochondria-targeted antioxidant MitoQ.
Annals of the New York Academy of Sciences 2010;1201():96-103.
2010: Sergio Rodriguez-Cuenca; Helena M Cochemé; Angela Logan; Irina Abakumova; Tracy A Prime; Claudia Rose; antonio vidal-puig; Anthony C Smith; David C Rubinsztein; Ian M Fearnley; Bruce A Jones; Simon Pope; Simon J R Heales; Brian Y H Lam; Sudeshna Guha Neogi; Ian McFarlane; Andrew M James; Robin A J Smith; Michael P Murphy
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.
Free radical biology & medicine 2010;48(1):161-72.
2009: Kristin K Brown; Frances H Blaikie; Robin A J Smith; Joel D A Tyndall; Hongqi Lue; Jürgen Bernhagen; Christine C Winterbourn; Mark Hampton
Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.
The Journal of biological chemistry 2009;284(47):32425-33.
2009: Delyth Graham; Ngan N Huynh; Carlene A Hamilton; Elisabeth Beattie; Robin A J Smith; Helena M Cochemé; Michael P Murphy; Anna F Dominiczak
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy.
Hypertension 2009;54(2):322-8.
2009: Jan Trnka; Frances H Blaikie; Angela Logan; Robin A J Smith; Michael P Murphy
Antioxidant properties of MitoTEMPOL and its hydroxylamine.
Free radical research 2009;43(1):4-12.
2008: Catherine E Hobbs; Michael P Murphy; Robin A J Smith; Dorothy E Oorschot
Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN.
Pediatrics international : official journal of the Japan Pediatric Society 2008;50(4):481-8.
2008: Meredith F Ross; Tracy A Prime; Irina Abakumova; Andrew M James; Carolyn M Porteous; Robin A J Smith; Michael P Murphy
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells.
The Biochemical journal 2008;411(3):633-45.
2008: Jan Trnka; Frances H Blaikie; Robin A J Smith; Michael P Murphy
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria.
Free radical biology & medicine 2008;44(7):1406-19.
2007: Stephanie E Brown; Meredith F Ross; Alejandra Sanjuan-Pla; Abdul-Rahman B Manas; Robin A J Smith; Michael P Murphy
Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative.
Free radical biology & medicine 2007;42(12):1766-80.
2007: Helena M Cochemé; Geoffrey F Kelso; Andrew M James; Meredith F Ross; Jan Trnka; Thabo Mahendiran; Jordi Asin-Cayuela; Frances H Blaikie; Abdul-Rahman B Manas; Carolyn M Porteous; Victoria J Adlam; Robin A J Smith; Michael P Murphy
Mitochondrial targeting of quinones: therapeutic implications.
Mitochondrion 2007;7 Suppl():S94-102.
2007: Andrew M James; Mark S Sharpley; Abdul-Rahman B Manas; Frank E Frerman; Judy Hirst; Robin A J Smith; Michael P Murphy
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases.
The Journal of biological chemistry 2007;282(20):14708-18.
2007: Michael P Murphy; Robin A J Smith
Targeting antioxidants to mitochondria by conjugation to lipophilic cations.
Annual review of pharmacology and toxicology 2007;47():629-56.
2006: Meredith F Ross; Tatiana Da Ros; Frances H Blaikie; Tracy A Prime; Carolyn M Porteous; Inna I Severina; Vladimir P Skulachev; Henrik G Kjaergaard; Robin A J Smith; Michael P Murphy
Accumulation of lipophilic dications by mitochondria and cells.
The Biochemical journal 2006;400(1):199-208.
2006: Frances H Blaikie; Stephanie E Brown; Linda M Samuelsson; Martin D Brand; Robin A J Smith; Michael P Murphy
Targeting dinitrophenol to mitochondria: limitations to the development of a self-limiting mitochondrial protonophore.
Bioscience reports 2006;26(3):231-43.
2006: Matthew V Covey; Michael P Murphy; Catherine E Hobbs; Robin A J Smith; Dorothy E Oorschot
Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study.
Experimental neurology 2006;199(2):513-9.
2005: Victoria J Adlam; Joanne C Harrison; Carolyn M Porteous; Andrew M James; Robin A J Smith; Michael P Murphy; Ivan A Sammut
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1088-95.
2005: Aleksandra Filipovska; Geoffrey F Kelso; Stephanie E Brown; Samantha M Beer; Robin A J Smith; Michael P Murphy
Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.
The Journal of biological chemistry 2005;280(25):24113-26.
2005: Andrew M James; Helena M Cochemé; Robin A J Smith; Michael P Murphy
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools.
The Journal of biological chemistry 2005;280(22):21295-312.
2004: Meredith F Ross; Aleksandra Filipovska; Robin A J Smith; Michael J Gait; Michael P Murphy
Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.
The Biochemical journal 2004;383(Pt. 3):457-68.
2004: Jordi Asin-Cayuela; Abdul-Rahman B Manas; Andrew M James; Robin A J Smith; Michael P Murphy
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant.
FEBS letters 2004;571(1-3):9-16.
2004: Andrew M James; Robin A J Smith; Michael P Murphy
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q.
Archives of biochemistry and biophysics 2004;423(1):47-56.
2004: Aleksandra Filipovska; Michael Eccles; Robin A J Smith; Michael P Murphy
Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation.
FEBS letters 2004;556(1-3):180-6.
2004: Robin A J Smith; Geoffrey F Kelso; Andrew M James; Michael P Murphy
Targeting coenzyme Q derivatives to mitochondria.
Methods in enzymology 2004;382():45-67.
2003: Michael P Murphy; Karim S Echtay; Frances H Blaikie; Jordi Asin-Cayuela; Helena M Cocheme; Katherine Green; Julie A Buckingham; Ellen R Taylor; Fiona Hurrell; Gillian Hughes; Satomi Miwa; Chris E Cooper; Dimitri A Svistunenko; Robin A J Smith; Martin D Brand
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
The Journal of biological chemistry 2003;278(49):48534-45.
2003: Andrew M James; Frances H Blaikie; Robin A J Smith; Robert N Lightowlers; Paul M Smith; Michael P Murphy
Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide.
European journal of biochemistry / FEBS 2003;270(13):2827-36.
2003: Robin A J Smith; Carolyn M Porteous; Alison M Gane; Michael P Murphy
Delivery of bioactive molecules to mitochondria in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5407-12.
2002: Karim S Echtay; Michael P Murphy; Robin A J Smith; Darren A Talbot; Martin D Brand
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants.
The Journal of biological chemistry 2002;277(49):47129-35.
2002: Tsu-Kung Lin; Gillian Hughes; Aleksandra Muratovska; Frances H Blaikie; Paul S Brookes; Victor Darley-Usmar; Robin A J Smith; Michael P Murphy
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach.
The Journal of biological chemistry 2002;277(19):17048-56.
2002: Geoffrey F Kelso; Carolyn M Porteous; Gillian Hughes; Elizabeth C Ledgerwood; Alison M Gane; Robin A J Smith; Michael P Murphy
Prevention of mitochondrial oxidative damage using targeted antioxidants.
Annals of the New York Academy of Sciences 2002;959():263-74.
2001: Aleksandra Muratovska; Robert N Lightowlers; Robert W Taylor; Douglass M Turnbull; Robin A J Smith; Jackie Wilce; S W Martin; Michael P Murphy
Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease.
Nucleic acids research 2001;29(9):1852-63.
2001: Geoffrey F Kelso; Carolyn M Porteous; CV Coulter; Gillian Hughes; WK Porteous; Elizabeth C Ledgerwood; Robin A J Smith; Michael P Murphy
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.
The Journal of biological chemistry 2001;276(7):4588-96.
2000: H R Palmer; Jennifer J Bedford; John P Leader; Robin A J Smith
31P and 1H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A.
The Journal of biological chemistry 2000;275(36):27708-11.
2000: CV Coulter; Geoffrey F Kelso; T K Lin; Robin A J Smith; Michael P Murphy
Mitochondrially targeted antioxidants and thiol reagents.
Free radical biology & medicine 2000;28(10):1547-54.
1999: Robin A J Smith; Carolyn M Porteous; CV Coulter; Michael P Murphy
Selective targeting of an antioxidant to mitochondria.
European journal of biochemistry / FEBS 1999;263(3):709-16.