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Stephen Smith

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Nigel J Pearce; Jonathan R S Arch; John Clapham; Matthew P Coghlan; Stacey L Corcoran; Carolyn A Lister; Andrea Llano; Gary B T Moore; Gregory J Murphy; Stephen A Smith; Colleen M Taylor; John W Yates; Alastair D Morrison; Alex J Harper; Lynne Roxbee-Cox; Alejandro Abuin; Ed Wargent; Julie C Holder
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
Ian R Jowsey; Stephen A Smith; John D Hayes
Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.
Josie A Blackie; Jackie C Bloomer; Murray J B Brown; Hung Yuan Cheng; Beverley Hammond; Deirdre M B Hickey; Robert J Ife; Colin A Leach; V Ann Lewis; Colin H Macphee; Kevin J Milliner; Kitty E Moores; Ivan L Pinto; Stephen A Smith; Ian G Stansfield; Steven J Stanway; Maxine A Taylor; Colin J Theobald
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

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All Publications

2004: Nigel J Pearce; Jonathan R S Arch; John Clapham; Matthew P Coghlan; Stacey L Corcoran; Carolyn A Lister; Andrea Llano; Gary B T Moore; Gregory J Murphy; Stephen A Smith; Colleen M Taylor; John W Yates; Alastair D Morrison; Alex J Harper; Lynne Roxbee-Cox; Alejandro Abuin; Ed Wargent; Julie C Holder
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
Metabolism: clinical and experimental 2004;53(10):1322-30.
2003: Ian R Jowsey; Stephen A Smith; John D Hayes
Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.
Biochemical and biophysical research communications 2003;312(4):1226-35.
2003: Josie A Blackie; Jackie C Bloomer; Murray J B Brown; Hung Yuan Cheng; Beverley Hammond; Deirdre M B Hickey; Robert J Ife; Colin A Leach; V Ann Lewis; Colin H Macphee; Kevin J Milliner; Kitty E Moores; Ivan L Pinto; Stephen A Smith; Ian G Stansfield; Steven J Stanway; Maxine A Taylor; Colin J Theobald
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
Bioorganic & medicinal chemistry letters 2003;13(6):1067-70.
2003: Lisa Patel; Amy C Buckels; Ian J Kinghorn; Paul R Murdock; Joanna D Holbrook; Christopher Plumpton; Colin H Macphee; Stephen A Smith
Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.
Biochemical and biophysical research communications 2003;300(2):472-6.
2003: Ian R Jowsey; Paul R Murdock; Gary B T Moore; Gregory J Murphy; Stephen A Smith; John D Hayes
Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues.
Prostaglandins & other lipid mediators 2003;70(3-4):267-84.
2002: Josie A Blackie; Jackie C Bloomer; Murray J B Brown; Hung-Yuan Cheng; Richard L Elliott; Beverley Hammond; Deirdre M B Hickey; Robert J Ife; Colin A Leach; V Ann Lewis; Colin H Macphee; Kevin J Milliner; Kitty E Moores; Ivan L Pinto; Stephen A Smith; Ian G Stansfield; Steven J Stanway; Maxine A Taylor; Colin J Theobald; Caroline M Whittaker
The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.
Bioorganic & medicinal chemistry letters 2002;12(18):2603-6.
2002: Lisa Patel; Steven J Charlton; Ian C Marshall; Gary B T Moore; Phil Coxon; Kitty E Moores; John Clapham; Suzanna J Newman; Stephen A Smith; Colin H Macphee
PPARgamma is not a critical mediator of primary monocyte differentiation or foam cell formation.
Biochemical and biophysical research communications 2002;290(2):707-12.
2002: Helen F Boyd; Stephen C M Fell; Deirdre M B Hickey; Robert J Ife; Colin A Leach; Colin H Macphee; Kevin J Milliner; Ivan L Pinto; D Anthony Rawlings; Stephen A Smith; Ian G Stansfield; Steven J Stanway; Colin J Theobald; Caroline M Whittaker
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.
Bioorganic & medicinal chemistry letters 2002;12(1):51-5.
2001: Helen Vosper; Lisa Patel; Tracey L Graham; Guennadi A Khoudoli; A Hill; Colin H Macphee; I Pinto; Stephen A Smith; Keith Suckling; C Roland Wolf; Colin N A Palmer
The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages.
The Journal of biological chemistry 2001;276(47):44258-65.
2001: Ian R Jowsey; AM Thomson; Jack U Flanagan; Paul R Murdock; Gary B T Moore; D J Meyer; Gregory J Murphy; Stephen A Smith; John D Hayes
Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases.
The Biochemical journal 2001;359(Pt 3):507-16.
2001: Gary B T Moore; Helen Chapman; Julie C Holder; Carolyn A Lister; V Piercy; Stephen A Smith; John Clapham
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.
Biochemical and biophysical research communications 2001;286(4):735-41.
2001: Jackie C Bloomer; Helen F Boyd; Deirdre M B Hickey; Robert J Ife; Colin A Leach; Colin H Macphee; Kevin J Milliner; Ivan L Pinto; D Anthony Rawlings; Stephen A Smith; Ian G Stansfield; Steven J Stanway; Maxine A Taylor; Colin J Theobald; Caroline M Whittaker
1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2).
Bioorganic & medicinal chemistry letters 2001;11(14):1925-9.
2001: Lisa Patel; Ian Pass; P Coxon; C Peter Downes; Stephen A Smith; Colin H Macphee
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.
Current biology : CB 2001;11(10):764-8.
2001: Helen F Boyd; Beverley Hammond; Deirdre M B Hickey; Robert J Ife; Colin A Leach; V Ann Lewis; Colin H Macphee; Kevin J Milliner; Ivan L Pinto; Stephen A Smith; Ian G Stansfield; Colin J Theobald; Caroline M Whittaker
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2.
Bioorganic & medicinal chemistry letters 2001;11(5):701-4.
2001: Colin A Leach; Deirdre M B Hickey; Robert J Ife; Colin H Macphee; Stephen A Smith; David Tew
Lipoprotein-associated PLA2 inhibition--a novel, non-lipid lowering strategy for atherosclerosis therapy.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):45-50.
2000: Stephen A Smith; Carolyn A Lister; CD Toseland; RE Buckingham
Rosiglitazone prevents the onset of hyperglycaemia and proteinuria in the Zucker diabetic fatty rat.
Diabetes, obesity & metabolism 2000;2(6):363-72.
2000: Helen F Boyd; S C Fell; S T Flynn; Deirdre M B Hickey; Robert J Ife; Colin A Leach; Colin H Macphee; Kevin J Milliner; Kitty E Moores; Ivan L Pinto; R A Porter; D Anthony Rawlings; Stephen A Smith; Ian G Stansfield; David Tew; Colin J Theobald; Caroline M Whittaker
N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.
Bioorganic & medicinal chemistry letters 2000;10(22):2557-61.
2000: John Clapham; Jonathan R S Arch; Helen Chapman; A Haynes; Carolyn A Lister; Gary B T Moore; V Piercy; S A Carter; I Lehner; Stephen A Smith; LJ Beeley; R J Godden; N Herrity; M Skehel; Kumar Changani; Paul D Hockings; David G Reid; S M Squires; Jonathan P Hatcher; B Trail; JK Latcham; S Rastan; Alex J Harper; Susana Cadenas; J A Buckingham; Martin D Brand; Alejandro Abuin
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
Nature 2000;406(6794):415-8.
2000: T Teruel; Stephen A Smith; J Peterson; John Clapham
Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARalpha and PPARgamma ligands.
Biochemical and biophysical research communications 2000;273(2):560-4.
2000: Helen F Boyd; S T Flynn; Deirdre M B Hickey; Robert J Ife; M Jones; Colin A Leach; Colin H Macphee; Kevin J Milliner; D Anthony Rawlings; Brian P Slingsby; Stephen A Smith; Ian G Stansfield; David Tew; Colin J Theobald
2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2.
Bioorganic & medicinal chemistry letters 2000;10(4):395-8.
1999: T Teruel; John Clapham; Stephen A Smith
PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes.
Biochemical and biophysical research communications 1999;264(2):311-5.
1999: V Piercy; SE Banner; A Bhattacharyya; A A Parsons; GJ Sanger; Stephen A Smith; Sharon Bingham
Thermal, but not mechanical, nociceptive behavior is altered in the Zucker Diabetic Fatty rat and is independent of glycemic status.
Journal of diabetes and its complications 1999;13(3):163-9.
1999: David Haigh; G Allen; Helen C Birrell; DR Buckle; B C Cantello; Drake S Eggleston; R Curtis Haltiwanger; Julie C Holder; Carolyn A Lister; Ivan L Pinto; H K Rami; J T Sime; Stephen A Smith; J D Sweeney
Non-thiazolidinedione antihyperglycaemic agents. Part 3: The effects of stereochemistry on the potency of alpha-methoxy-beta-phenylpropanoic acids.
Bioorganic & medicinal chemistry 1999;7(5):821-30.
1999: Nigel E Austin; KY Avenell; Izzy Boyfield; Clive L Branch; Martin Coldwell; Michael S Hadley; Phillip Jeffrey; A Johns; Christopher N Johnson; David J Nash; Graham J Riley; Stephen A Smith; RC Stacey; Geoffrey Stemp; Kevin M Thewlis; Antonio K K Vong
Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor.
Bioorganic & medicinal chemistry letters 1999;9(2):179-84.
1998: KY Avenell; Izzy Boyfield; Martin Coldwell; Michael S Hadley; M A Healy; Phillip Jeffrey; Christopher N Johnson; David J Nash; Graham J Riley; E E Scott; Stephen A Smith; RC Stacey; Geoffrey Stemp; Kevin M Thewlis
Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor.
Bioorganic & medicinal chemistry letters 1998;8(20):2859-64.
1998: Matthew V Sennitt; Alberto J Kaumann; P Molenaar; LJ Beeley; PW Young; J Kelly; Helen Chapman; S M Henson; J M Berge; D K Dean; N R Kotecha; H K Morgan; H K Rami; R W Ward; M Thompson; S Wilson; Stephen A Smith; Michael A Cawthorne; MJ Stock; Jonathan R S Arch
The contribution of classical (beta1/2-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta3-adrenoceptor agonists of differing selectivities.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1084-95.
1998: PW Young; DR Buckle; B C Cantello; Helen Chapman; John Clapham; P J Coyle; David Haigh; R M Hindley; Julie C Holder; H Kallender; A J Latter; K W Lawrie; DE Mossakowska; Gregory J Murphy; Lynne Roxbee-Cox; Stephen A Smith
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.
The Journal of pharmacology and experimental therapeutics 1998;284(2):751-9.
1997: John Clapham; Stephen A Smith; Gary B T Moore; M G Hughes; H Azam; A Scott; R T Jung
Plasma leptin concentrations and OB gene expression in subcutaneous adipose tissue are not regulated acutely by physiological hyperinsulinaemia in lean and obese humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(3):179-83.
1996: Izzy Boyfield; T H Brown; Martin Coldwell; D G Cooper; Michael S Hadley; James Hagan; M A Healy; A Johns; R J King; Derek N Middlemiss; David J Nash; Graham J Riley; E E Scott; Stephen A Smith; Geoffrey Stemp
Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists.
Journal of medicinal chemistry 1996;39(10):1946-8.
1995: P W Young; Michael A Cawthorne; P J Coyle; Julie C Holder; Geoffrey D Holman; I J Kozka; D M Kirkham; C A Lister; Stephen A Smith
Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.
Diabetes 1995;44(9):1087-92.
1994: B C Cantello; Michael A Cawthorne; G P Cottam; P T Duff; David Haigh; R M Hindley; C A Lister; Stephen A Smith; P L Thurlby
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.
Journal of medicinal chemistry 1994;37(23):3977-85.
1994: M A Oriowo; Matthew V Sennitt; Stephen A Smith; RR Ruffolo; Michael A Cawthorne
The beta-adrenoceptor selectivity profile of BRL 37344 in the pithed rat.
Journal of autonomic pharmacology 1994;14(5):337-44.
1993: B Beszant; J Bird; Laramie M Gaster; G P Harper; I Hughes; EH Karran; RE Markwell; A J Miles-Williams; Stephen A Smith
Synthesis of novel modified dipeptide inhibitors of human collagenase: beta-mercapto carboxylic acid derivatives.
Journal of medicinal chemistry 1993;36(25):4030-9.
1992: Michael A Cawthorne; Matthew V Sennitt; Jonathan R S Arch; Stephen A Smith
BRL 35135, a potent and selective atypical beta-adrenoceptor agonist.
The American journal of clinical nutrition 1992;55(1 Suppl):252S-257S.
1986: E A Boyle; F R Mangan; RE Markwell; Stephen A Smith; M J Thomson; R W Ward; P A Wyman
7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents.
Journal of medicinal chemistry 1986;29(6):894-8.
1986: Stephen A Smith; Michael A Cawthorne; D L Simson
Glucose metabolism in the obese hyperglycaemic (C57B1/6 ob/ob) mouse: the effects of fasting on glucose turnover rates.
Diabetes research (Edinburgh, Scotland) 1986;3(2):83-6.
1985: Stephen A Smith; A L Levy; Matthew V Sennitt; D L Simson; Michael A Cawthorne
Effects of BRL 26830, a novel beta-adrenoceptor agonist, on glucose tolerance, insulin sensitivity and glucose turnover in Zucker (fa/fa) rats.
Biochemical pharmacology 1985;34(14):2425-9.
1985: Matthew V Sennitt; Jonathan R S Arch; A L Levy; D L Simson; Stephen A Smith; Michael A Cawthorne
Anti-hyperglycaemic action of BRL 26830, a novel beta-adrenoceptor agonist, in mice and rats.
Biochemical pharmacology 1985;34(8):1279-85.
1984: Michael A Cawthorne; M J Carroll; A L Levy; C A Lister; Matthew V Sennitt; Stephen A Smith; P Young
Effects of novel beta-adrenoceptor agonists on carbohydrate metabolism: relevance for the treatment of non-insulin-dependent diabetes.
International journal of obesity 1984;8 Suppl 1():93-102.
1983: Stephen A Smith; Michael A Cawthorne; A L Levy; D L Simson
Defective activation by glucose of hepatic glycogen synthesis in the obese hyperglycaemic mouse.
The Biochemical journal 1983;216(2):491-4.