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Thomas Smithgall

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TOP 3
Linda P O'Reilly; Xiong Zhang; Thomas E Smithgall
Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.
Shoghag Panjarian; Shugui Chen; John R Engen; Roxana E Iacob; Thomas E Wales; Thomas E Smithgall
Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.
Shoghag Panjarian; Shugui Chen; John R Engen; Roxana E Iacob; Thomas E Smithgall
Structure and dynamic regulation of Abl kinases.

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All Publications

2013: Linda P O'Reilly; Xiong Zhang; Thomas E Smithgall
Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.
Cellular signalling 2013;25(4):860-6.
2013: Shoghag Panjarian; Shugui Chen; John R Engen; Roxana E Iacob; Thomas E Wales; Thomas E Smithgall
Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.
The Journal of biological chemistry 2013;288(9):6116-29.
2013: Shoghag Panjarian; Shugui Chen; John R Engen; Roxana E Iacob; Thomas E Smithgall
Structure and dynamic regulation of Abl kinases.
The Journal of biological chemistry 2013;288(8):5443-50.
2013: Lori A Emert-Sedlak; Paul A Johnston; John S Lazo; Purushottam Narute; Jerrod A Poe; Haibin Shi; Sherry T Shu; Naveena Yanamala; Joanne I Yeh; John Jeff Alvarado; Thomas E Smithgall
Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.
Chemistry & biology 2013;20(1):82-91.
2012: Sabine Hellwig; Wooyoung Hur; Shigeru Kanda; Stefan Knapp; Chandra V Miduturu; Eidarus Salah; Hwan Geun Choi; Xianming Deng; Panagis Filippakopoulos; Nathanael S Gray; Jianming Zhang; Wenjun Zhou; Thomas E Smithgall
Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.
Chemistry & biology 2012;19(4):529-40.
2012: Teodora Pene-Dumitrescu; Haibin Shi; Sherry T Shu; John J Alvarado; John R Engen; Jamie A Moroco; Purushottam Narute; Thomas E Wales; Joanne I Yeh; Thomas E Smithgall
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.
BMC chemical biology 2012;12():1.
2012: Purushottam S Narute; Thomas E Smithgall
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.
PloS one 2012;7(2):e32561.
2011: Judong Lee; Jamie A Moroco; Jiayao Phuah; Thomas E Smithgall; Ee Wern Su; Chen Zhu; Sarah Hainline; Vijay K Kuchroo; Lawrence P Kane
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.
Molecular and cellular biology 2011;31(19):3963-74.
2011: Sean R Marcsisin; Purushottam S Narute; Thomas E Smithgall; Lori A Emert-Sedlak; Marek Kloczewiak; John R Engen
On the solution conformation and dynamics of the HIV-1 viral infectivity factor.
Journal of molecular biology 2011;410(5):1008-22.
2011: Sabine Hellwig; Thomas E Smithgall
Structure and regulation of the c-Fes protein-tyrosine kinase.
Frontiers in bioscience : a journal and virtual library 2011;16():3146-55.
2011: Linda P O'Reilly; Simon C Watkins; Thomas E Smithgall
An unexpected role for the clock protein timeless in developmental apoptosis.
PloS one 2011;6(2):e17157.
2010: John J Alvarado; Laurie Betts; Jamie A Moroco; Thomas E Smithgall; Joanne I Yeh
Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism.
The Journal of biological chemistry 2010;285(46):35455-61.
2010: Jimmy D Dikeakos; Katelyn M Atkins; Laurel Thomas; Lori Emert-Sedlak; In-Ja L Byeon; Jinwon Jung; Jinwoo Ahn; matthew d wortman; Ben Kukull; Masumichi Saito; Hirokazu Koizumi; Danielle M Williamson; Masateru Hiyoshi; Eric Barklis; Masafumi Takiguchi; Shinya Suzu; Angela M Gronenborn; Thomas E Smithgall; Gary Thomas
Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.
Molecular biology of the cell 2010;21(19):3279-92.
2010: Teodora Pene-Dumitrescu; Thomas E Smithgall
Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.
The Journal of biological chemistry 2010;285(28):21446-57.
2010: Eric D de Groh; Lisa M Swanhart; Chiara Cianciolo Cosentino; Rachel L Jackson; Weixiang Dai; Carolyn A Kitchens; Billy W Day; Thomas E Smithgall; Neil A Hukriede
Inhibition of histone deacetylase expands the renal progenitor cell population.
Journal of the American Society of Nephrology : JASN 2010;21(5):794-802.
2010: Zhaoxia Qu; Pengrong Yan; Jing Fu; Jing Jiang; Michael J Grusby; Thomas E Smithgall; Gutian Xiao
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.
Cancer research 2010;70(5):1766-72.
2009: Alec A Schmaier; Zhiying Zou; Arunas Kazlauskas; Lori Emert-Sedlak; Karen P Fong; Keith B Neeves; Sean F Maloney; Scott L Diamond; Satya P Kunapuli; Jerry Ware; Lawrence F Brass; Thomas E Smithgall; Kalle Saksela; Mark L Kahn
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(50):21167-72.
2009: Jerrod A Poe; Thomas E Smithgall
HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.
Journal of molecular biology 2009;394(2):329-42.
2009: Lori Emert-Sedlak; Toshiaki Kodama; Edwina C Lerner; Weixiang Dai; Caleb Foster; Billy W Day; John Lazo; Thomas E Smithgall
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.
ACS chemical biology 2009;4(11):939-47.
2009: Yongmun Choi; Markus A Seeliger; Shoghag B Panjarian; Hakjoong Kim; Xianming Deng; Taebo Sim; Brian Couch; Anthony J Koleske; Thomas E Smithgall; Nathanael S Gray
N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.
The Journal of biological chemistry 2009;284(42):29005-14.
2009: Gabriela Molina; Andreas Vogt; Ahmet Bakan; Weixiang Dai; Pierre Queiroz de Oliveira; Wade Znosko; Thomas E Smithgall; Ivet Bahar; John Lazo; Billy W Day; Michael Tsang
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.
Nature chemical biology 2009;5(9):680-7.
2009: Jonathan Shaffer; Sabine Hellwig; Thomas E Smithgall
Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.
Biochemistry 2009;48(22):4780-8.
2009: Jonathan M Shaffer; Thomas E Smithgall
Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer.
Genes, chromosomes & cancer 2009;48(3):272-84.
2009: Roxana E Iacob; Teodora Pene-Dumitrescu; Jianming Zhang; Nathanael S Gray; Thomas E Smithgall; John R Engen
Conformational disturbance in Abl kinase upon mutation and deregulation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1386-91.
2009: Malcolm Meyn; Thomas E Smithgall
Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.
Science signaling 2009;2(92):ra64.
2008: T Pene-Dumitrescu; Luke Peterson; Nicholas J Donato; Thomas E Smithgall
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.
Oncogene 2008;27(56):7055-69.
2008: Shugui Chen; Linda P O'Reilly; Thomas E Smithgall; John R Engen
Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
Journal of molecular biology 2008;383(2):414-23.
2008: Malcolm Meyn; Thomas E Smithgall
Small molecule inhibitors of Lck: the search for specificity within a kinase family.
Mini reviews in medicinal chemistry 2008;8(6):628-37.
2008: Shugui Chen; Teodora Pene Dumitrescu; Thomas E Smithgall; John R Engen
Abl N-terminal cap stabilization of SH3 domain dynamics.
Biochemistry 2008;47(21):5795-803.
2007: Ronald P Trible; Lori Emert-Sedlak; Thomas E Wales; Velpandi Ayyavoo; John R Engen; Thomas E Smithgall
Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.
Journal of molecular biology 2007;374(1):121-9.
2007: Shigeru Kanda; Yasuyoshi Miyata; Hiroshi Kanetake; Thomas E Smithgall
Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review).
International journal of molecular medicine 2007;20(1):113-21.
2007: Shugui Chen; Sébastien Brier; Thomas E Smithgall; John R Engen
The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.
Protein science : a publication of the Protein Society 2007;16(4):572-81.
2007: Jennifer L Mitchell; Ronald P Trible; Lori Emert-Sedlak; David D Weis; Edwina C Lerner; Jeremy J Applen; Bartholomew M Sefton; Thomas E Smithgall; John R Engen
Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein.
Journal of molecular biology 2007;366(4):1282-93.
2006: Yuh-Ping Chong; Andrew S Chan; Khai-Chew Chan; Nicholas A Williamson; Edwina C Lerner; Thomas E Smithgall; Jeffrey D Bjorge; Donald J Fujita; Anthony W Purcell; Glen M Scholz; Terrence D Mulhern; Heung-Chin Cheng
C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.
The Journal of biological chemistry 2006;281(44):32988-99.
2006: Malcolm Meyn; Matthew B Wilson; Fadi A Abdi; Nathalie Fahey; Anthony P Schiavone; Jiong Wu; James M Hochrein; John R Engen; Thomas E Smithgall
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.
The Journal of biological chemistry 2006;281(41):30907-16.
2006: Shigeru Kanda; Yasuyoshi Miyata; Hiroshi Kanetake; Thomas E Smithgall
Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly.
Experimental cell research 2006;312(16):3015-22.
2006: Frank J Delfino; Jonathan Shaffer; Thomas E Smithgall
The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.
The Biochemical journal 2006;399(1):141-50.
2006: Ronald P Trible; Lori Emert-Sedlak; Thomas E Smithgall
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.
The Journal of biological chemistry 2006;281(37):27029-38.
2006: James M Hochrein; Thomas E Wales; Edwina C Lerner; Anthony P Schiavone; Thomas E Smithgall; John R Engen
Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry.
Biochemistry 2006;45(25):7733-9.
2006: Qing Zhang; Sufi Thomas; Vivian Wai Yan Lui; Sichuan Xi; Jill M Siegfried; Huizhou Fan; Thomas E Smithgall; Gordon B Mills; Jennifer Rubin Grandis
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6901-6.
2006: Frank J Delfino; Heather Stevenson; Thomas E Smithgall
A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.
The Journal of biological chemistry 2006;281(13):8829-35.
2006: James M Hochrein; Edwina C Lerner; Anthony P Schiavone; Thomas E Smithgall; John R Engen
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.
Protein science : a publication of the Protein Society 2006;15(1):65-73.
2005: Edwina C Lerner; Ronald P Trible; Anthony P Schiavone; James M Hochrein; John R Engen; Thomas E Smithgall
Activation of the Src family kinase Hck without SH3-linker release.
The Journal of biological chemistry 2005;280(49):40832-7.
2005: Malcolm Meyn; Steven J Schreiner; Teodora Pene Dumitrescu; Gerard J Nau; Thomas E Smithgall
SRC family kinase activity is required for murine embryonic stem cell growth and differentiation.
Molecular pharmacology 2005;68(5):1320-30.
2004: Huihui Ye; Hyun-Jung Choi; Jerrod Poe; Thomas E Smithgall
Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck.
Biochemistry 2004;43(50):15775-84.
2004: Hyun-Jung Choi; Thomas E Smithgall
HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner.
The Journal of biological chemistry 2004;279(49):51688-96.
2004: Hyun-Jung Choi; Thomas E Smithgall
Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.
Journal of molecular biology 2004;343(5):1255-68.
2004: Charles E Laurent; Frank J Delfino; Haiyun Y Cheng; Thomas E Smithgall
The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.
Molecular and cellular biology 2004;24(21):9351-8.
2004: Charles E Laurent; Thomas E Smithgall
The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Experimental cell research 2004;299(1):188-98.
2004: Qing Zhang; Sufi Thomas; Sichuan Xi; Thomas E Smithgall; Jill M Siegfried; Joanne Kamens; William Gooding; Jennifer Rubin Grandis
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.
Cancer research 2004;64(17):6166-73.
2004: Haiyun Y Cheng; Ping Li; Michael David; Thomas E Smithgall; Lili Feng; Michael W Lieberman
Arsenic inhibition of the JAK-STAT pathway.
Oncogene 2004;23(20):3603-12.
2003: Sichuan Xi; Qing Zhang; William Gooding; Thomas E Smithgall; Jennifer Rubin Grandis
Constitutive activation of Stat5b contributes to carcinogenesis in vivo.
Cancer research 2003;63(20):6763-71.
2003: Sanjeev Shangary; Edwina C Lerner; Qimin Zhan; Seth J Corey; Thomas E Smithgall; Rajasekaran Baskaran
Lyn regulates the cell death response to ultraviolet radiation through c-Jun N terminal kinase-dependent Fas ligand activation.
Experimental cell research 2003;289(1):67-76.
2003: Sichuan Xi; Qing Zhang; Kevin F Dyer; Edwina C Lerner; Thomas E Smithgall; William Gooding; Joanne Kamens; Jennifer Rubin Grandis
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck.
The Journal of biological chemistry 2003;278(34):31574-83.
2003: Yoshio Takashima; Frank J Delfino; John R Engen; Giulio Superti-Furga; Thomas E Smithgall
Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae.
Biochemistry 2003;42(12):3567-74.
2003: Annemarie Shibata; Charles E Laurent; Thomas E Smithgall
The c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism.
Cellular signalling 2003;15(3):279-88.
2002: Steven J Schreiner; Anthony P Schiavone; Thomas E Smithgall
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.
The Journal of biological chemistry 2002;277(47):45680-7.
2002: Matthew B Wilson; Steven J Schreiner; Hyun-Jung Choi; Joanne Kamens; Thomas E Smithgall
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
Oncogene 2002;21(53):8075-88.
2002: Agata Klejman; Steven J Schreiner; Margaret Nieborowska-Skorska; Artur Slupianek; Matthew Wilson; Thomas E Smithgall; Tomasz Skorski
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
The EMBO journal 2002;21(21):5766-74.
2002: Edwina C Lerner; Thomas E Smithgall
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.
Nature structural biology 2002;9(5):365-9.
2002: Paul L Leong; Sichuan Xi; Stephanie D Drenning; Kevin F Dyer; Abbey L Wentzel; Edwina C Lerner; Thomas E Smithgall; Jennifer Rubin Grandis
Differential function of STAT5 isoforms in head and neck cancer growth control.
Oncogene 2002;21(18):2846-53.
2001: Shanhai Xie; Yunfei Wang; Jinsong Liu; Tong Sun; Matthew B Wilson; Thomas E Smithgall; Ralph B Arlinghaus
Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.
Oncogene 2001;20(43):6188-95.
2001: Haiyun Y Cheng; Anthony P Schiavone; Thomas E Smithgall
A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells.
Molecular and cellular biology 2001;21(18):6170-80.
2001: SD Briggs; B Scholtz; Jean-Marc Jacque; Simon Swingler; Mario Stevenson; Thomas E Smithgall
HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway.
The Journal of biological chemistry 2001;276(27):25605-11.
2001: William H Gmeiner; I Xu; David A Horita; Thomas E Smithgall; John R Engen; D L Smith; R Andrew Byrd
Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP.
Cell biochemistry and biophysics 2001;35(2):115-26.
2000: J A Rogers; Haiyun Y Cheng; Thomas E Smithgall
Src homology 2 domain substitution modulates the kinase and transforming activities of the Fes protein-tyrosine kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(11):581-92.
2000: Y Zhang; James Turkson; Christin Carter-Su; Thomas E Smithgall; Alexander Levitzki; Alan J Kraker; J J Krolewski; P Medveczky; Richard Jove
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
The Journal of biological chemistry 2000;275(32):24935-44.
2000: JM Lionberger; Matthew B Wilson; Thomas E Smithgall
Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck.
The Journal of biological chemistry 2000;275(24):18581-5.
2000: Thomas E Smithgall; SD Briggs; Steven J Schreiner; Edwina C Lerner; H Cheng; Matthew B Wilson
Control of myeloid differentiation and survival by Stats.
Oncogene 2000;19(21):2612-8.
2000: R T Glover; M Angiolieri; S Kelly; Daniel T Monaghan; J Y Wang; Thomas E Smithgall; AL Buller
Interaction of the N-methyl-D-aspartic acid receptor NR2D subunit with the c-Abl tyrosine kinase.
The Journal of biological chemistry 2000;275(17):12725-9.
2000: Shigeru Kanda; Edwina C Lerner; S Tsuda; T Shono; Hiroshi Kanetake; Thomas E Smithgall
The nonreceptor protein-tyrosine kinase c-Fes is involved in fibroblast growth factor-2-induced chemotaxis of murine brain capillary endothelial cells.
The Journal of biological chemistry 2000;275(14):10105-11.
2000: JM Lionberger; Thomas E Smithgall
The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl.
Cancer research 2000;60(4):1097-103.
2000: SD Briggs; Edwina C Lerner; Thomas E Smithgall
Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.
Biochemistry 2000;39(3):489-95.
2000: David A Horita; W Zhang; Thomas E Smithgall; William H Gmeiner; R Andrew Byrd
Dynamics of the Hck-SH3 domain: comparison of experiment with multiple molecular dynamics simulations.
Protein science : a publication of the Protein Society 2000;9(1):95-103.
1999: H Cheng; JA Rogers; N A Dunham; Thomas E Smithgall
Regulation of c-Fes tyrosine kinase and biological activities by N-terminal coiled-coil oligomerization domains.
Molecular and cellular biology 1999;19(12):8335-43.
1999: SD Briggs; Thomas E Smithgall
SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.
The Journal of biological chemistry 1999;274(37):26579-83.
1999: John R Engen; William H Gmeiner; Thomas E Smithgall; David L Smith
Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
Biochemistry 1999;38(28):8926-35.
1999: K L Peters; Thomas E Smithgall
Tyrosine phosphorylation enhances the SH2 domain-binding activity of Bcr and inhibits Bcr interaction with 14-3-3 proteins.
Cellular signalling 1999;11(7):507-14.
1999: John R Engen; Thomas E Smithgall; William H Gmeiner; David L Smith
Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation.
Journal of molecular biology 1999;287(3):645-56.
1998: J Li; Thomas E Smithgall
Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation.
The Journal of biological chemistry 1998;273(22):13828-34.
1998: W Zhang; Thomas E Smithgall; William H Gmeiner
Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms.
Biochemistry 1998;37(20):7119-26.
1998: David A Horita; D M Baldisseri; W Zhang; Amanda S Altieri; Thomas E Smithgall; William H Gmeiner; R Andrew Byrd
Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
Journal of molecular biology 1998;278(1):253-65.
1998: K L Nelson; JA Rogers; T L Bowman; Richard Jove; Thomas E Smithgall
Activation of STAT3 by the c-Fes protein-tyrosine kinase.
The Journal of biological chemistry 1998;273(12):7072-7.
1998: Thomas E Smithgall
Signal transduction pathways regulating hematopoietic differentiation.
Pharmacological reviews 1998;50(1):1-19.
1998: Thomas E Smithgall; JA Rogers; K L Peters; J Li; SD Briggs; JM Lionberger; H Cheng; A Shibata; B Scholtz; Steven J Schreiner; N Dunham
The c-Fes family of protein-tyrosine kinases.
Critical reviews in oncogenesis 1998;9(1):43-62.
1997: Roy Garcia; C L Yu; A Hudnall; R Catlett; K L Nelson; Thomas E Smithgall; D J Fujita; Stephen Ethier; Richard Jove
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(12):1267-76.
1997: John R Engen; Thomas E Smithgall; William H Gmeiner; David L Smith
Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.
Biochemistry 1997;36(47):14384-91.
1997: W Zhang; Thomas E Smithgall; William H Gmeiner
Three-dimensional structure of the Hck SH2 domain in solution.
Journal of biomolecular NMR 1997;10(3):263-72.
1997: R D Read; JM Lionberger; Thomas E Smithgall
Oligomerization of the Fes tyrosine kinase. Evidence for a coiled-coil domain in the unique N-terminal region.
The Journal of biological chemistry 1997;272(29):18498-503.
1997: SD Briggs; Mark E Sharkey; Mario Stevenson; Thomas E Smithgall
SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.
The Journal of biological chemistry 1997;272(29):17899-902.
1997: W Zhang; Thomas E Smithgall; William H Gmeiner
Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.
FEBS letters 1997;406(1-2):131-5.
1996: J Li; Thomas E Smithgall
Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.
The Journal of biological chemistry 1996;271(51):32930-6.
1996: S C Nair; E J Toran; Ronald A Rimerman; S Hjermstad; Thomas E Smithgall; David F Smith
A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.
Cell stress & chaperones 1996;1(4):237-50.
1996: J A Rogers; R D Read; J Li; K L Peters; Thomas E Smithgall
Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues.
The Journal of biological chemistry 1996;271(29):17519-25.
1996: W Zhang; Thomas E Smithgall; William H Gmeiner
Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment.
Journal of magnetic resonance. Series B 1996;111(3):305-9.
1996: A G Bukrinskaya; Anuja Ghorpade; N K Heinzinger; Thomas E Smithgall; Robert Lewis; Mario Stevenson
Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):367-71.
1995: Thomas E Smithgall
SH2 and SH3 domains: potential targets for anti-cancer drug design.
Journal of pharmacological and toxicological methods 1995;34(3):125-32.
1995: S S Bryant; SD Briggs; Thomas E Smithgall; G A Martin; F McCormick; J H Chang; S J Parsons; Richard Jove
Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein.
The Journal of biological chemistry 1995;270(30):17947-52.
1995: SD Briggs; S S Bryant; Richard Jove; Sam D Sanderson; Thomas E Smithgall
The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck.
The Journal of biological chemistry 1995;270(24):14718-24.
1995: Yoshiro Maru; K L Peters; D E Afar; M Shibuya; O N Witte; Thomas E Smithgall
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
Molecular and cellular biology 1995;15(2):835-42.
1993: S J Hjermstad; SD Briggs; Thomas E Smithgall
Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism.
Biochemistry 1993;32(39):10519-25.
1993: S J Hjermstad; K L Peters; SD Briggs; R I Glazer; Thomas E Smithgall
Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).
Oncogene 1993;8(8):2283-92.