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Mark Smyth

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
O' Reilly Lorraine A; Tai Lin; Lee Lily; Kruse Elizabeth A; Grabow Stephanie; Fairlie W Douglas; Haynes Nicole M; Tarlinton David M; Zhang Jian-Guo; Belz Gabrielle T; Smyth Mark J; Bouillet Philippe; Robb Lorraine; Strasser Andreas
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
Starr Robyn; Fuchsberger Martina; Lau Lei Shong; Uldrich Adam P; Goradia Ankita; Willson Tracy A; Verhagen Anne M; Alexander Warren S; Smyth Mark J
SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo.
Sumaria Nital; van Dommelen Serani L H; Andoniou Christopher E; Smyth Mark J; Scalzo Anthony A; Degli-Esposti Mariapia A
The roles of interferon-gamma and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity.

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All Publications

2009: O' Reilly Lorraine A; Tai Lin; Lee Lily; Kruse Elizabeth A; Grabow Stephanie; Fairlie W Douglas; Haynes Nicole M; Tarlinton David M; Zhang Jian-Guo; Belz Gabrielle T; Smyth Mark J; Bouillet Philippe; Robb Lorraine; Strasser Andreas
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
Nature 2009;461(7264):659-63.
2009: Starr Robyn; Fuchsberger Martina; Lau Lei Shong; Uldrich Adam P; Goradia Ankita; Willson Tracy A; Verhagen Anne M; Alexander Warren S; Smyth Mark J
SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4537-44.
2009: Sumaria Nital; van Dommelen Serani L H; Andoniou Christopher E; Smyth Mark J; Scalzo Anthony A; Degli-Esposti Mariapia A
The roles of interferon-gamma and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity.
Immunology and cell biology 2009;87(7):559-66.
2009: Teng Michele W L; Sharkey Janelle; McLaughlin Nicole M; Exley Mark A; Smyth Mark J
CD1d-based combination therapy eradicates established tumors in mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1911-20.
2009: Ritchie David S; Smyth Mark J
A new therapeutic target for leukemia comes to the surface.
Cell 2009;138(2):226-8.
2009: Pellicci Daniel G; Patel Onisha; Kjer-Nielsen Lars; Pang Siew Siew; Sullivan Lucy C; Kyparissoudis Konstantinos; Brooks Andrew G; Reid Hugh H; Gras Stephanie; Lucet Isabelle S; Koh Ruide; Smyth Mark J; Mallevaey Thierry; Matsuda Jennifer L; Gapin Laurent; McCluskey James; Godfrey Dale I; Rossjohn Jamie
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors.
Immunity 2009;31(1):47-59.
2009: Swann Jeremy B; Uldrich Adam P; van Dommelen Serani; Sharkey Janelle; Murray William K; Godfrey Dale I; Smyth Mark J
Type I natural killer T cells suppress tumors caused by p53 loss in mice.
Blood 2009;113(25):6382-5.
2009: Broomfield Steve A; van der Most Robbert G; Prosser Amy C; Mahendran Sathish; Tovey Michael G; Smyth Mark J; Robinson Bruce W S; Currie Andrew J
Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5217-24.
2009: Westwood Jennifer A; Murray William K; Trivett Melanie; Haynes Nicole M; Solomon Benjamin; Mileshkin Linda; Ball David; Michael Michael; Burman Angela; Mayura-Guru Preethi; Trapani Joseph A; Peinert Stefan; Hönemann Dirk; Miles Prince H; Scott Andrew M; Smyth Mark J; Darcy Phillip K; Kershaw Michael H
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(3):292-301.
2009: Teng Michele W L; Yue Simon; Sharkey Janelle; Exley Mark A; Smyth Mark J
CD1d activation and blockade: a new antitumor strategy.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3366-71.
2009: Bolitho Paul; Street Shayna E A; Westwood Jennifer A; Edelmann Winfried; Macgregor Duncan; Waring Paul; Murray William K; Godfrey Dale I; Trapani Joseph A; Johnstone Ricky W; Smyth Mark J
Perforin-mediated suppression of B-cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2723-8.
2009: Kaufmann Thomas; Jost Philipp J; Pellegrini Marc; Puthalakath Hamsa; Gugasyan Raffi; Gerondakis Steve; Cretney Erika; Smyth Mark J; Silke John; Hakem Razq; Bouillet Philippe; Mak Tak W; Dixit Vishva M; Strasser Andreas
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Immunity 2009;30(1):56-66.
2009: van der Most Robbert G; Currie Andrew J; Cleaver Amanda L; Salmons Joanne; Nowak Anna K; Mahendran Sathish; Larma Irma; Prosser Amy; Robinson Bruce W S; Smyth Mark J; Scalzo Anthony A; Degli-Esposti Mariapia A; Lake Richard A
Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth.
PloS one 2009;4(9):e6982.
2008: Stagg John; Sharkey Janelle; Pommey Sandra; Young Richard; Takeda Kazuyoshi; Yagita Hideo; Johnstone Ricky W; Smyth Mark J
Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16254-9.
2008: Watt Sally V; Andrews Daniel M; Takeda Kazuyoshi; Smyth Mark J; Hayakawa Yoshihiro
IFN-gamma-dependent recruitment of mature CD27(high) NK cells to lymph nodes primed by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5323-30.
2008: Johnstone Ricky W; Frew Ailsa J; Smyth Mark J
The TRAIL apoptotic pathway in cancer onset, progression and therapy.
Nature reviews. Cancer 2008;8(10):782-98.
2008: Haynes Nicole M; van der Most Robbert G; Lake Richard A; Smyth Mark J
Immunogenic anti-cancer chemotherapy as an emerging concept.
Current opinion in immunology 2008;20(5):545-57.
2008: Teng Michele W L; Swann Jeremy B; Koebel Catherine M; Schreiber Robert D; Smyth Mark J
Immune-mediated dormancy: an equilibrium with cancer.
Journal of leukocyte biology 2008;84(4):988-93.
2008: Pegram Hollie J; Jackson Jacob T; Smyth Mark J; Kershaw Michael H; Darcy Phillip K
Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3449-55.
2008: Coquet Jonathan M; Chakravarti Sumone; Kyparissoudis Konstantinos; McNab Finlay W; Pitt Lauren A; McKenzie Brent S; Berzins Stuart P; Smyth Mark J; Godfrey Dale I
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11287-92.
2008: Frew Ailsa J; Lindemann Ralph K; Martin Ben P; Clarke Christopher J P; Sharkey Janelle; Anthony Desiree A; Banks Kellie-Marie; Haynes Nicole M; Gangatirkar Pradnya; Stanley Kym; Bolden Jessica E; Takeda Kazuyoshi; Yagita Hideo; Secrist J Paul; Smyth Mark J; Johnstone Ricky W
Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11317-22.
2008: Westwood J A; Murray W K; Trivett M; Shin A; Neeson P; MacGregor D P; Haynes N M; Trapani J A; Mayura-Guru P; Fox S; Peinert S; Honemann D; Prince H M; Ritchie D; Scott A M; Smyth F E; Smyth M J; Darcy P K; Kershaw M H
Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice.
Gene therapy 2008;15(14):1056-66.
2008: Coquet Jonathan M; Chakravarti Sumone; Smyth Mark J; Godfrey Dale I
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7097-101.
2008: Andrews Daniel M; Andoniou Christopher E; Fleming Peter; Smyth Mark J; Degli-Esposti Mariapia A
The early kinetics of cytomegalovirus-specific CD8+ T-cell responses are not affected by antigen load or the absence of perforin or gamma interferon.
Journal of virology 2008;82(10):4931-7.
2008: Smyth Mark J; Teng Michele W L; Sharkey Janelle; Westwood Jennifer A; Haynes Nicole M; Yagita Hideo; Takeda Kazuyoshi; Sivakumar Pallavur V; Kershaw Michael H
Interleukin 21 enhances antibody-mediated tumor rejection.
Cancer research 2008;68(8):3019-25.
2008: Andrews Daniel M; Maraskovsky Eugene; Smyth Mark J
Cancer vaccines for established cancer: how to make them better?
Immunological reviews 2008;222():242-55.
2008: Silva Anabel; Andrews Daniel M; Brooks Andrew G; Smyth Mark J; Hayakawa Yoshihiro
Application of CD27 as a marker for distinguishing human NK cell subsets.
International immunology 2008;20(4):625-30.
2008: Skak Kresten; Kragh Michael; Hausman Diana; Smyth Mark J; Sivakumar Pallavur V
Interleukin 21: combination strategies for cancer therapy.
Nature reviews. Drug discovery 2008;7(3):231-40.
2008: Cretney Erika; Uldrich Adam P; McNab Finlay W; Godfrey Dale I; Smyth Mark J
No requirement for TRAIL in intrathymic negative selection.
International immunology 2008;20(2):267-76.
2008: Swann Jeremy B; Vesely Matthew D; Silva Anabel; Sharkey Janelle; Akira Shizuo; Schreiber Robert D; Smyth Mark J
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):652-6.
2007: Moeller Maria; Kershaw Michael H; Cameron Rachel; Westwood Jennifer A; Trapani Joseph A; Smyth Mark J; Darcy Phillip K
Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells.
Cancer research 2007;67(23):11428-37.
2007: Davis Ian D; Skak Kresten; Smyth Mark J; Kristjansen Paul E G; Miller Dennis M; Sivakumar Pallavur V
Interleukin-21 signaling: functions in cancer and autoimmunity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):6926-32.
2007: Koebel Catherine M; Vermi William; Swann Jeremy B; Zerafa Nadeen; Rodig Scott J; Old Lloyd J; Smyth Mark J; Schreiber Robert D
Adaptive immunity maintains occult cancer in an equilibrium state.
Nature 2007;450(7171):903-7.
2007: Stagg John; Johnstone Ricky W; Smyth Mark J
From cancer immunosurveillance to cancer immunotherapy.
Immunological reviews 2007;220():82-101.
2007: McNab Finlay W; Pellicci Daniel G; Field Kenneth; Besra Gurdyal; Smyth Mark J; Godfrey Dale I; Berzins Stuart P
Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6630-7.
2007: Caminschi Irina; Ahmet Fatma; Heger Klaus; Brady Jason; Nutt Stephen L; Vremec David; Pietersz Suzanne; Lahoud Mireille H; Schofield Louis; Hansen Diana S; O'Keeffe Meredith; Smyth Mark J; Bedoui Sammy; Davey Gayle M; Villadangos Jose A; Heath William R; Shortman Ken
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.
The Journal of experimental medicine 2007;204(11):2579-90.
2007: Teng Michele W L; Westwood Jennifer A; Darcy Phillip K; Sharkey Janelle; Tsuji Moriya; Franck Richard W; Porcelli Steven A; Besra Gurdyal S; Takeda Kazuyoshi; Yagita Hideo; Kershaw Michael H; Smyth Mark J
Combined natural killer T-cell based immunotherapy eradicates established tumors in mice.
Cancer research 2007;67(15):7495-504.
2007: Huntington Nicholas D; Puthalakath Hamsa; Gunn Priscilla; Naik Edwina; Michalak Ewa M; Smyth Mark J; Tabarias Hyacinth; Degli-Esposti Mariapia A; Dewson Grant; Willis Simon N; Motoyama Noboru; Huang David C S; Nutt Stephen L; Tarlinton David M; Strasser Andreas
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.
Nature immunology 2007;8(8):856-63.
2007: Swann Jeremy B; Hayakawa Yoshihiro; Zerafa Nadeen; Sheehan Kathleen C F; Scott Bernadette; Schreiber Robert D; Hertzog Paul; Smyth Mark J
Type I IFN contributes to NK cell homeostasis, activation, and antitumor function.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7540-9.
2007: Street Shayna E A; Zerafa Nadeen; Iezzi Manuela; Westwood Jennifer A; Stagg John; Musiani Piero; Smyth Mark J
Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinoma.
Cancer research 2007;67(11):5454-60.
2007: Bolitho Paul; Voskoboinik Ilia; Trapani Joseph A; Smyth Mark J
Apoptosis induced by the lymphocyte effector molecule perforin.
Current opinion in immunology 2007;19(3):339-47.
2007: Swann Jeremy B; Smyth Mark J
Immune surveillance of tumors.
The Journal of clinical investigation 2007;117(5):1137-46.
2007: Lindemann R K; Newbold A; Whitecross K F; Cluse L A; Frew A J; Ellis L; Williams S; Wiegmans A P; Dear A E; Scott C L; Pellegrini M; Wei A; Richon V M; Marks Paul A; Lowe S W; Smyth M J; Johnstone R W
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8071-6.
2007: Murphy A; Westwood J A; Brown L E; Teng M W L; Moeller M; Xu Y; Smyth M J; Hwu P; Darcy P K; Kershaw M H
Antitumor activity of dual-specific T cells and influenza virus.
Cancer gene therapy 2007;14(5):499-508.
2007: Stagg John; Smyth Mark J
NK cell-based cancer immunotherapy.
Drug news & perspectives 2007;20(3):155-63.
2007: Huntington Nicholas D; Tabarias Hy; Fairfax Kirsten; Brady Jason; Hayakawa Yoshihiro; Degli-Esposti Mariapia A; Smyth Mark J; Tarlinton David M; Nutt Stephen L
NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4764-70.
2007: Coquet Jonathan M; Kyparissoudis Konstantinos; Pellicci Daniel G; Besra Gurdyal; Berzins Stuart P; Smyth Mark J; Godfrey Dale I
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2827-34.
2007: Swann J B; Coquet J M C; Smyth M J; Godfrey D I
CD1-restricted T cells and tumor immunity.
Current topics in microbiology and immunology 2007;314():293-323.
2007: Smyth Mark J; Swann Jeremy; Hayakawa Yoshihiro
Innate tumor immune surveillance.
Advances in experimental medicine and biology 2007;590():103-11.
2006: Voskoboinik Ilia; Smyth Mark J; Trapani Joseph A
Perforin-mediated target-cell death and immune homeostasis.
Nature reviews. Immunology 2006;6(12):940-52.
2006: Hayakawa Yoshihiro; Huntington Nicholas D; Nutt Stephen L; Smyth Mark J
Functional subsets of mouse natural killer cells.
Immunological reviews 2006;214():47-55.
2006: van Dommelen Serani L H; Sumaria Nital; Schreiber Robert D; Scalzo Anthony A; Smyth Mark J; Degli-Esposti Mariapia A
Perforin and granzymes have distinct roles in defensive immunity and immunopathology.
Immunity 2006;25(5):835-48.
2006: Teng Michele W L; Kershaw Michael H; Jackson Jacob T; Smyth Mark J; Darcy Phillip K
Adoptive transfer of chimeric FcepsilonRI gene-modified human T cells for cancer immunotherapy.
Human gene therapy 2006;17(11):1134-43.
2006: Abdool Karen; Cretney Erika; Brooks Alan D; Kelly Janice M; Swann Jeremy; Shanker Anil; Bere Earl W; Yokoyama Wayne M; Ortaldo John R; Smyth Mark J; Sayers Thomas J
NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2575-83.
2006: Hayakawa Yoshihiro; Berzins Stuart P; Crowe Nadine Y; Godfrey Dale I; Smyth Mark J
Retraction: Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors.
Nature immunology 2006;7(8):890.
2006: Hayakawa Yoshihiro; Smyth Mark J
NKG2D and cytotoxic effector function in tumor immune surveillance.
Seminars in immunology 2006;18(3):176-85.
2006: Smyth Mark J
Imatinib mesylate--uncovering a fast track to adaptive immunity.
The New England journal of medicine 2006;354(21):2282-4.
2006: Smyth Mark J; Hayakawa Yoshihiro; Cretney Erika; Zerafa Nadeen; Sivakumar Pallavur; Yagita Hideo; Takeda Kazuyoshi
IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6347-55.
2006: Uldrich Adam P; Berzins Stuart P; Malin Mark A; Bouillet Philippe; Strasser Andreas; Smyth Mark J; Boyd Richard L; Godfrey Dale I
Antigen challenge inhibits thymic emigration.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4553-61.
2006: Reading Patrick C; Whitney Paul G; Barr Daniel P; Smyth Mark J; Brooks Andrew G
NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection.
European journal of immunology 2006;36(4):897-905.
2006: Berzins Stuart P; McNab Finlay W; Jones Claerwen M; Smyth Mark J; Godfrey Dale I
Long-term retention of mature NK1.1+ NKT cells in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4059-65.
2006: Kjer-Nielsen Lars; Borg Natalie A; Pellicci Daniel G; Beddoe Travis; Kostenko Lyudmila; Clements Craig S; Williamson Nicholas A; Smyth Mark J; Besra Gurdyal S; Reid Hugh H; Bharadwaj Mandvi; Godfrey Dale I; Rossjohn Jamie; McCluskey James
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
The Journal of experimental medicine 2006;203(3):661-73.
2006: Smyth Mark J; Teng Michele W L; Swann Jeremy; Kyparissoudis Konstantinos; Godfrey Dale I; Hayakawa Yoshihiro
CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1582-7.
2006: Hayakawa Yoshihiro; Smyth Mark J
CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1517-24.
2006: Cretney Erika; Shanker Anil; Yagita Hideo; Smyth Mark J; Sayers Thomas J
TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer.
Immunology and cell biology 2006;84(1):87-98.
2006: Cornish Ann L; Keating Rachael; Kyparissoudis Konstantinos; Smyth Mark J; Carbone Francis R; Godfrey Dale I
NKT cells are not critical for HSV-1 disease resolution.
Immunology and cell biology 2006;84(1):13-9.
2006: Hayakawa Yoshihiro; Smyth Mark J
Innate immune recognition and suppression of tumors.
Advances in cancer research 2006;95():293-322.
2006: Smyth Mark J; Dunn Gavin P; Schreiber Robert D
Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity.
Advances in immunology 2006;90():1-50.
2005: Westwood Jennifer A; Smyth Mark J; Teng Michele W L; Moeller Maria; Trapani Joseph A; Scott Andrew M; Smyth Fiona E; Cartwright Glenn A; Power Barbara E; Hönemann Dirk; Prince H Miles; Darcy Phillip K; Kershaw Michael H
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19051-6.
2005: Kershaw Michael H; Teng Michele W L; Smyth Mark J; Darcy Phillip K
Supernatural T cells: genetic modification of T cells for cancer therapy.
Nature reviews. Immunology 2005;5(12):928-40.
2005: Crowe Nadine Y; Coquet Jonathan M; Berzins Stuart P; Kyparissoudis Konstantinos; Keating Rachael; Pellicci Daniel G; Hayakawa Yoshihiro; Godfrey Dale I; Smyth Mark J
Differential antitumor immunity mediated by NKT cell subsets in vivo.
The Journal of experimental medicine 2005;202(9):1279-88.
2005: Zerafa Nadeen; Westwood Jennifer A; Cretney Erika; Mitchell Sally; Waring Paul; Iezzi Manuela; Smyth Mark J
Cutting edge: TRAIL deficiency accelerates hematological malignancies.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5586-90.
2005: Teng Michele W L; Kershaw Michael H; Hayakawa Yoshihiro; Cerutti Loretta; Jane Stephen M; Darcy Phillip K; Smyth Mark J
T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner.
The Journal of biological chemistry 2005;280(46):38235-41.
2005: Moeller Maria; Haynes Nicole M; Kershaw Michael H; Jackson Jacob T; Teng Michele W L; Street Shayna E; Cerutti Loretta; Jane Stephen M; Trapani Joseph A; Smyth Mark J; Darcy Phillip K
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection.
Blood 2005;106(9):2995-3003.
2005: Pellicci Daniel G; Hammond Kirsten J L; Coquet Jonathan; Kyparissoudis Konstantinos; Brooks Andrew G; Kedzierska Katherine; Keating Rachael; Turner Stephen; Berzins Stuart; Smyth Mark J; Godfrey Dale I
DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4416-25.
2005: Cretney Erika; McQualter Jonathan L; Kayagaki Nobuhiko; Yagita Hideo; Bernard Claude C A; Grewal Iqbal S; Ashkenazi Avi; Smyth Mark J
TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice.
Immunology and cell biology 2005;83(5):511-9.
2005: McNab Finlay W; Berzins Stuart P; Pellicci Daniel G; Kyparissoudis Konstantinos; Field Kenneth; Smyth Mark J; Godfrey Dale I
The influence of CD1d in postselection NKT cell maturation and homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3762-8.
2005: Smyth Mark J; Swann Jeremy; Cretney Erika; Zerafa Nadeen; Yokoyama Wayne M; Hayakawa Yoshihiro
NKG2D function protects the host from tumor initiation.
The Journal of experimental medicine 2005;202(5):583-8.
2005: Pao Lily I; Sumaria Nital; Kelly Janice M; van Dommelen Serani; Cretney Erika; Wallace Morgan E; Anthony Desiree A; Uldrich Adam P; Godfrey Dale I; Papadimitriou John M; Mullbacher Arno; Degli-Esposti Mariapia A; Smyth Mark J
Functional analysis of granzyme M and its role in immunity to infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3235-43.
2005: Uldrich Adam P; Crowe Nadine Y; Kyparissoudis Konstantinos; Pellicci Daniel G; Zhan Yifan; Lew Andrew M; Bouillet Philippe; Strasser Andreas; Smyth Mark J; Godfrey Dale I
NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3092-101.
2005: Takaki Rayna; Hayakawa Yoshihiro; Nelson Andrew; Sivakumar Pallavur V; Hughes Steven; Smyth Mark J; Lanier Lewis L
IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2167-73.
2005: Berzins Stuart P; Smyth Mark J; Godfrey Dale I
Working with NKT cells--pitfalls and practicalities.
Current opinion in immunology 2005;17(4):448-54.
2005: Smyth Mark J; Wallace Morgan E; Nutt Stephen L; Yagita Hideo; Godfrey Dale I; Hayakawa Yoshihiro
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer.
The Journal of experimental medicine 2005;201(12):1973-85.
2005: Wallace Morgan E; Smyth Mark J
The role of natural killer cells in tumor control--effectors and regulators of adaptive immunity.
Springer seminars in immunopathology 2005;27(1):49-64.
2005: Berzins Stuart P; Cochrane Andrew D; Pellicci Daniel G; Smyth Mark J; Godfrey Dale I
Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples.
European journal of immunology 2005;35(5):1399-407.
2005: Voskoboinik Ilia; Thia Marie-Claude; Fletcher Jamie; Ciccone Annette; Browne Kylie; Smyth Mark J; Trapani Joseph A
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.
The Journal of biological chemistry 2005;280(9):8426-34.
2005: Degli-Esposti Mariapia A; Smyth Mark J
Close encounters of different kinds: dendritic cells and NK cells take centre stage.
Nature reviews. Immunology 2005;5(2):112-24.
2005: Akhurst Barbara; Matthews Vance; Husk Kirsten; Smyth Mark J; Abraham Lawrence J; Yeoh George C
Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury.
Hepatology (Baltimore, Md.) 2005;41(2):327-35.
2005: Andrews Daniel M; Andoniou Christopher E; Scalzo Anthony A; van Dommelen Serani L H; Wallace Morgan E; Smyth Mark J; Degli-Esposti Mariapia A
Cross-talk between dendritic cells and natural killer cells in viral infection.
Molecular immunology 2005;42(4):547-55.
2005: Smyth Mark J; Cretney Erika; Kelly Janice M; Westwood Jennifer A; Street Shayna E A; Yagita Hideo; Takeda Kazuyoshi; van Dommelen Serani L H; Degli-Esposti Mariapia A; Hayakawa Yoshihiro
Activation of NK cell cytotoxicity.
Molecular immunology 2005;42(4):501-10.
2005: Cretney Erika; Uldrich Adam P; Berzins Stuart P; Strasser Andreas; Godfrey Dale I; Smyth Mark J
Are we really on the right TRAIL?
Immunologic research 2005;31(2):161-4.
2004: Godfrey Dale I; Pellicci Daniel G; Smyth Mark J
Immunology. The elusive NKT cell antigen--is the search over?
Science (New York, N.Y.) 2004;306(5702):1687-9.
2004: Smyth Mark J; Cretney Erika; Kershaw Michael H; Hayakawa Yoshihiro
Cytokines in cancer immunity and immunotherapy.
Immunological reviews 2004;202():275-93.
2004: Smyth Mark J; Swann Jeremy; Kelly Janice M; Cretney Erika; Yokoyama Wayne M; Diefenbach Andreas; Sayers Thomas J; Hayakawa Yoshihiro
NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer.
The Journal of experimental medicine 2004;200(10):1325-35.
2004: Voskoboinik Ilia; Thia Marie-Claude; De Bono Annette; Browne Kylie; Cretney Erika; Jackson Jacob T; Darcy Phillip K; Jane Stephen M; Smyth Mark J; Trapani Joseph A
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene.
The Journal of experimental medicine 2004;200(6):811-6.
2004: Tainton K M; Smyth M J; Jackson J T; Tanner J E; Cerruti L; Jane S M; Darcy P K; Johnstone R W
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.
Cell death and differentiation 2004;11(9):1028-37.
2004: Kershaw Michael H; Jackson Jacob T; Haynes Nicole M; Teng Michele W L; Moeller Maria; Hayakawa Yoshihiro; Street Shayna E; Cameron Rachel; Tanner Jane E; Trapani Joseph A; Smyth Mark J; Darcy Phillip K
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2143-50.
2004: Teng Michele W L; Kershaw Michael H; Moeller Maria; Smyth Mark J; Darcy Phillip K
Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes.
Human gene therapy 2004;15(7):699-708.
2004: Swann Jeremy; Crowe Nadine Y; Hayakawa Yoshihiro; Godfrey Dale I; Smyth Mark J
Regulation of antitumour immunity by CD1d-restricted NKT cells.
Immunology and cell biology 2004;82(3):323-31.
2004: Berzins Stuart P; Uldrich Adam P; Pellicci Daniel G; McNab Finlay; Hayakawa Yoshihiro; Smyth Mark J; Godfrey Dale I
Parallels and distinctions between T and NKT cell development in the thymus.
Immunology and cell biology 2004;82(3):269-75.
2004: Berzins Stuart P; Kyparissoudis Kon; Pellicci Daniel G; Hammond Kristen J; Sidobre Stephane; Baxter Alan; Smyth Mark J; Kronenberg Mitchell; Godfrey Dale I
Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies.
Immunology and cell biology 2004;82(3):247-52.
2004: Hayakawa Yoshihiro; Berzins Stuart P; Crowe Nadine Y; Godfrey Dale I; Smyth Mark J
Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors.
Nature immunology 2004;5(6):590-6.
2004: Moeller Maria; Haynes Nicole M; Trapani Joseph A; Teng Michele W L; Jackson Jacob T; Tanner Jane E; Cerutti Loretta; Jane Stephen M; Kershaw Michael H; Smyth Mark J; Darcy Phillip K
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells.
Cancer gene therapy 2004;11(5):371-9.
2004: Kelly Janice M; Waterhouse Nigel J; Cretney Erika; Browne Kylie A; Ellis Sarah; Trapani Joseph A; Smyth Mark J
Granzyme M mediates a novel form of perforin-dependent cell death.
The Journal of biological chemistry 2004;279(21):22236-42.
2004: Dyer Christopher M; Zhan Yifan; Brady Jamie L; Carbone Francis R; Smyth Mark J; Lew Andrew M
Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization.
Blood 2004;103(8):3073-5.
2004: Godfrey Dale I; MacDonald H Robson; Kronenberg Mitchell; Smyth Mark J; Van Kaer Luc
NKT cells: what's in a name?
Nature reviews. Immunology 2004;4(3):231-7.
2004: Street Shayna E A; Hayakawa Yoshihiro; Zhan Yifan; Lew Andrew M; MacGregor Duncan; Jamieson Amanda M; Diefenbach Andreas; Yagita Hideo; Godfrey Dale I; Smyth Mark J
Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells.
The Journal of experimental medicine 2004;199(6):879-84.
2004: Brady Jason; Hayakawa Yoshihiro; Smyth Mark J; Nutt Stephen L
IL-21 induces the functional maturation of murine NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2048-58.
2004: Hayakawa Yoshihiro; Godfrey Dale I; Smyth Mark J
Alpha-galactosylceramide: potential immunomodulatory activity and future application.
Current medicinal chemistry 2004;11(2):241-52.
2004: Westwood Jennifer A; Kelly Janice M; Tanner Jane E; Kershaw Michael H; Smyth Mark J; Hayakawa Yoshihiro
Cutting edge: novel priming of tumor-specific immunity by NKG2D-triggered NK cell-mediated tumor rejection and Th1-independent CD4+ T cell pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):757-61.
2004: Hayakawa Yoshihiro; Screpanti Valentina; Yagita Hideo; Grandien Alf; Ljunggren Hans-Gustaf; Smyth Mark J; Chambers Benedict J
NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):123-9.
2004: Nutt Stephen L; Brady Jason; Hayakawa Yoshihiro; Smyth Mark J
Interleukin 21: a key player in lymphocyte maturation.
Critical reviews in immunology 2004;24(4):239-50.
2003: Crowe Nadine Y; Uldrich Adam P; Kyparissoudis Konstantinos; Hammond Kirsten J L; Hayakawa Yoshihiro; Sidobre Stephané; Keating Rachael; Kronenberg Mitchell; Smyth Mark J; Godfrey Dale I
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4020-7.
2003: Cretney Erika; Uldrich Adam P; Berzins Stuart P; Strasser Andreas; Godfrey Dale I; Smyth Mark J
Normal thymocyte negative selection in TRAIL-deficient mice.
The Journal of experimental medicine 2003;198(3):491-6.
2003: Hayakawa Yoshihiro; Rovero Stefania; Forni Guido; Smyth Mark J
Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9464-9.
2003: Smyth Mark J; Street Shayna E A; Trapani Joseph A
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):515-8.
2003: Pellicci Daniel G; Uldrich Adam P; Kyparissoudis Konstantinos; Crowe Nadine Y; Brooks Andrew G; Hammond Kirsten J L; Sidobre Stephané; Kronenberg Mitchell; Smyth Mark J; Godfrey Dale I
Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide.
European journal of immunology 2003;33(7):1816-23.
2003: Smyth Mark J; Kershaw Michael H
Discovery of an innate cancer resistance gene?
Molecular interventions 2003;3(4):186-9.
2003: van Dommelen Serani L H; Tabarias Hyacinth A; Smyth Mark J; Degli-Esposti Mariapia A
Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells.
Journal of virology 2003;77(3):1877-84.
2003: Andrews Daniel M; Scalzo Anthony A; Yokoyama Wayne M; Smyth Mark J; Degli-Esposti Mariapia A
Functional interactions between dendritic cells and NK cells during viral infection.
Nature immunology 2003;4(2):175-81.
2003: Smyth Mark J; Takeda Kazuyoshi; Hayakawa Yoshihiro; Peschon Jacques J; van den Brink Marcel R M; Yagita Hideo
Nature's TRAIL--on a path to cancer immunotherapy.
Immunity 2003;18(1):1-6.
2003: Seki Naoko; Hayakawa Yoshihiro; Brooks Alan D; Wine John; Wiltrout Robert H; Yagita Hideo; Tanner Jane E; Smyth Mark J; Sayers Thomas J
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer.
Cancer research 2003;63(1):207-13.
2002: Haynes Nicole M; Trapani Joseph A; Teng Michele W L; Jackson Jacob T; Cerruti Loretta; Jane Stephen M; Kershaw Michael H; Smyth Mark J; Darcy Phillip K
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5780-6.
2002: Hayakawa Yoshihiro; Kelly Janice M; Westwood Jennifer A; Darcy Phillip K; Diefenbach Andreas; Raulet David; Smyth Mark J
Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5377-81.
2002: Ruefli A A; Tainton K M; Darcy P K; Smyth M J; Johnstone R W
P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.
Cell death and differentiation 2002;9(11):1266-72.
2002: Haynes Nicole M; Trapani Joseph A; Teng Michèle W L; Jackson Jacob T; Cerruti Loretta; Jane Stephen M; Kershaw Michael H; Smyth Mark J; Darcy Phillip K
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors.
Blood 2002;100(9):3155-63.
2002: Cretney Erika; Street Shayna E A; Smyth Mark J
TNF contributes to the immunopathology of perforin/Fas ligand double deficiency.
Immunology and cell biology 2002;80(5):436-40.
2002: Street Shayna E A; Trapani Joseph A; MacGregor Duncan; Smyth Mark J
Suppression of lymphoma and epithelial malignancies effected by interferon gamma.
The Journal of experimental medicine 2002;196(1):129-34.
2002: Crowe Nadine Y; Smyth Mark J; Godfrey Dale I
A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas.
The Journal of experimental medicine 2002;196(1):119-27.
2002: Ruefli Astrid A; Bernhard David; Tainton Kellie M; Kofler Reinhard; Smyth Mark J; Johnstone Ricky W
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells.
International journal of cancer. Journal international du cancer 2002;99(2):292-8.
2002: Kelly Janice M; Takeda Kazuyoshi; Darcy Phillip K; Yagita Hideo; Smyth Mark J
A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4472-9.
2002: Pellicci Daniel G; Hammond Kirsten J L; Uldrich Adam P; Baxter Alan G; Smyth Mark J; Godfrey Dale I
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage.
The Journal of experimental medicine 2002;195(7):835-44.
2002: Seki Naoko; Brooks Alan D; Carter Clive R D; Back Timothy C; Parsoneault Erin M; Smyth Mark J; Wiltrout Robert H; Sayers Thomas J
Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3484-92.
2002: Smyth Mark J; Crowe Nadine Y; Hayakawa Yoshihiro; Takeda Kazuyoshi; Yagita Hideo; Godfrey Dale I
NKT cells - conductors of tumor immunity?
Current opinion in immunology 2002;14(2):165-71.
2002: Baxter Alan G; Smyth Mark J
The role of NK cells in autoimmune disease.
Autoimmunity 2002;35(1):1-14.
2002: Smyth Mark J; Crowe Nadine Y; Pellicci Daniel G; Kyparissoudis Konstantinos; Kelly Janice M; Takeda Kazuyoshi; Yagita Hideo; Godfrey Dale I
Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide.
Blood 2002;99(4):1259-66.
2002: Cretney Erika; Takeda Kazuyoshi; Yagita Hideo; Glaccum Moira; Peschon Jacques J; Smyth Mark J
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1356-61.
2002: Kelly Janice M; Darcy Phillip K; Markby Jessica L; Godfrey Dale I; Takeda Kazuyoshi; Yagita Hideo; Smyth Mark J
Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection.
Nature immunology 2002;3(1):83-90.
2001: Ruefli A A; Ausserlechner M J; Bernhard D; Sutton V R; Tainton K M; Kofler R; Smyth M J; Johnstone R W
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10833-8.
2001: Smyth M J; Trapani J A
Lymphocyte-mediated immunosurveillance of epithelial cancers?
Trends in immunology 2001;22(8):409-11.
2001: Smyth M J; Kelly J M; Sutton V R; Davis J E; Browne K A; Sayers T J; Trapani J A
Unlocking the secrets of cytotoxic granule proteins.
Journal of leukocyte biology 2001;70(1):18-29.
2001: Poulton L D; Smyth M J; Hawke C G; Silveira P; Shepherd D; Naidenko O V; Godfrey D I; Baxter A G
Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice.
International immunology 2001;13(7):887-96.
2001: Johnstone R W; Tainton K M; Ruefli A A; Froelich C J; Cerruti L; Jane S M; Smyth M J
P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
The Journal of biological chemistry 2001;276(20):16667-73.
2001: Smyth M J; Crowe N Y; Godfrey D I
NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.
International immunology 2001;13(4):459-63.
2001: Smyth M J; Godfrey D I; Trapani J A
A fresh look at tumor immunosurveillance and immunotherapy.
Nature immunology 2001;2(4):293-9.
2001: Sayers T J; Brooks A D; Ward J M; Hoshino T; Bere W E; Wiegand G W; Kelly J M; Smyth M J;
The restricted expression of granzyme M in human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):765-71.
2001: Street S E; Cretney E; Smyth M J
Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.
Blood 2001;97(1):192-7.
2001: Haynes N M; Snook M B; Trapani J A; Cerruti L; Jane S M; Smyth M J; Darcy P K
Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):182-7.
2000: Godfrey D I; Hammond K J; Poulton L D; Smyth M J; Baxter A G
NKT cells: facts, functions and fallacies.
Immunology today 2000;21(11):573-83.
2000: Davis J E; Sutton V R; Smyth M J; Trapani J A
Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1.
Cell death and differentiation 2000;7(10):973-83.
2000: Tainton K M; Ruefli A A; Smyth M J; Johnstone R W
Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine.
Biochemical and biophysical research communications 2000;276(1):231-7.
2000: Smyth M J; Thia K Y; Street S E; MacGregor D; Godfrey D I; Trapani J A
Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma.
The Journal of experimental medicine 2000;192(5):755-60.
2000: Smyth M J; Taniguchi M; Street S E
The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2665-70.
2000: Sayers T J; Brooks A D; Seki N; Smyth M J; Yagita H; Blazar B R; Malyguine A M
T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas.
Journal of leukocyte biology 2000;68(1):81-6.
2000: Johnstone R W; Ruefli A A; Tainton K M; Smyth M J
A role for P-glycoprotein in regulating cell death.
Leukemia & lymphoma 2000;38(1-2):1-11.
2000: Ruefli A A; Smyth M J; Johnstone R W
HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance.
Blood 2000;95(7):2378-85.
2000: Darcy P K; Haynes N M; Snook M B; Trapani J A; Cerruti L; Jane S M; Smyth M J
Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3705-12.
2000: Smyth M J; Thia K Y; Street S E; Cretney E; Trapani J A; Taniguchi M; Kawano T; Pelikan S B; Crowe N Y; Godfrey D I
Differential tumor surveillance by natural killer (NK) and NKT cells.
The Journal of experimental medicine 2000;191(4):661-8.
2000: Johnstone R W; Ruefli A A; Smyth M J
Multiple physiological functions for multidrug transporter P-glycoprotein?
Trends in biochemical sciences 2000;25(1):1-6.
2000: Körner H; Cretney E; Wilhelm P; Kelly J M; Röllinghoff M; Sedgwick J D; Smyth M J
Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype.
The Journal of experimental medicine 2000;191(1):89-96.
1999: Hammond K J; Pelikan S B; Crowe N Y; Randle-Barrett E; Nakayama T; Taniguchi M; Smyth M J; van Driel I R; Scollay R; Baxter A G; Godfrey D I
NKT cells are phenotypically and functionally diverse.
European journal of immunology 1999;29(11):3768-81.
1999: Smyth M J; Kelly J M
Accessory function for NK1.1+ natural killer cells producing interferon-gamma in xenospecific cytotoxic T lymphocyte differentiation.
Transplantation 1999;68(6):840-3.
1999: Smyth M J; Snook M B
Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice.
Cellular immunology 1999;196(1):51-9.
1999: Smyth M J; Johnstone R W; Cretney E; Haynes N M; Sedgwick J D; Korner H; Poulton L D; Baxter A G
Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1350-3.
1999: Smyth M J; Thia K Y; Cretney E; Kelly J M; Snook M B; Forbes C A; Scalzo A A
Perforin is a major contributor to NK cell control of tumor metastasis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6658-62.
1999: Johnstone R W; Cretney E; Smyth M J
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death.
Blood 1999;93(3):1075-85.
1999: Haynes N M; Smyth M J; Kershaw M H; Trapani J A; Darcy P K
Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes.
Cancer immunology, immunotherapy : CII 1999;47(5):278-86.
1998: Smyth M J; Sedgwick J D
Delayed kinetics of tumor necrosis factor-mediated bystander lysis by peptide-specific CD8+ cytotoxic T lymphocytes.
European journal of immunology 1998;28(12):4162-9.
1998: Smyth M J; Kelly J M; Baxter A G; Körner H; Sedgwick J D
An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum.
The Journal of experimental medicine 1998;188(9):1611-9.
1998: Trapani J A; Jans D A; Jans P J; Smyth M J; Browne K A; Sutton V R
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent.
The Journal of biological chemistry 1998;273(43):27934-8.
1998: Smyth M J; Krasovskis E; Johnstone R W
Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes.
Journal of virology 1998;72(7):5948-54.
1998: Trapani J A; Jans P; Smyth M J; Froelich C J; Williams E A; Sutton V R; Jans D A
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
Cell death and differentiation 1998;5(6):488-96.
1998: Smyth M J; Krasovskis E; Sutton V R; Johnstone R W
The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7024-9.
1998: Darcy P K; Kershaw M H; Trapani J A; Smyth M J
Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma.
European journal of immunology 1998;28(5):1663-72.
1998: Smyth M J; Kershaw M H; Darcy P K
Xenospecific CD8+ cytotoxic T lymphocyte generation: accessory function for CD4+ T cells and natural killer 1.1+ cells.
Transplantation 1998;65(9):1278-81.
1998: Smyth M J; Kershaw M H; Darcy P K; Trapani J A
Adoptive transfer: the role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo.
Xenotransplantation 1998;5(2):146-53.
1998: Smyth M J; Trapani J A
The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology.
Journal of virology 1998;72(1):1-9.
1998: Kershaw M H; Darcy P K; Trapani J A; MacGregor D; Smyth M J
Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth.
Oncology research 1998;10(3):133-42.
1997: Smyth M J
Fas ligand-mediated bystander lysis of syngeneic cells in response to an allogeneic stimulus.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5765-72.
1997: Ewoldt G R; Smyth M J; Darcy P K; Harris J L; Craik C S; Horowitz B; Woodard S L; Powers J C; Hudig D
P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4574-83.
1997: Smyth M J; Kershaw M H; Trapani J A
Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo.
Transplantation 1997;63(8):1171-8.
1997: Ewoldt G R; Darcy P K; Snook M B; Hudig D; Smyth M J
cDNA cloning of granzyme J.
Immunogenetics 1997;45(6):452-4.
1996: Kershaw M H; Darcy P K; Trapani J A; Smyth M J
The use of chimeric human Fc(epsilon) receptor I to redirect cytotoxic T lymphocytes to tumors.
Journal of leukocyte biology 1996;60(6):721-8.
1996: Smyth M J; Sutton V R; Kershaw M H; Trapani J A
Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways.
Transplantation 1996;62(10):1529-32.
1996: Smyth M J; O'Connor M D; Trapani J A
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.
Journal of leukocyte biology 1996;60(5):555-62.
1996: Kershaw M H; Darcy P K; Hulett M D; Hogarth P M; Trapani J A; Smyth M J
Redirected cytotoxic effector function. Requirements for expression of chimeric single chain high affinity immunoglobulin e receptors.
The Journal of biological chemistry 1996;271(35):21214-20.
1996: Smyth M J; O'Connor M D; Trapani J A; Kershaw M H; Brinkworth R I
A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4174-81.
1996: Sayers T J; Lloyd A R; McVicar D W; O'Connor M D; Kelly J M; Carter C R; Wiltrout T A; Wiltrout R H; Smyth M J
Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3.
Journal of leukocyte biology 1996;59(5):763-8.
1996: Trapani J A; Browne K A; Smyth M J; Jans D A
Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis.
The Journal of biological chemistry 1996;271(8):4127-33.
1996: Kelly J M; O'Connor M D; Hulett M D; Thia K Y; Smyth M J
Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1.
Immunogenetics 1996;44(5):340-50.
1995: Smyth M J; Kershaw M H
Cytotoxic lymphocyte-mediated immunotherapy.
Australian and New Zealand journal of medicine 1995;25(6):852-8.
1995: Smyth M J; O'Connor M D; Kelly J M; Ganesvaran P; Thia K Y; Trapani J A
Expression of recombinant human Met-ase-1: a NK cell-specific granzyme.
Biochemical and biophysical research communications 1995;217(2):675-83.
1995: Apostolidis V A; Browne K A; Smyth M J; Trapani J A
The peptide loop consisting of amino acids 139-157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse.
Molecular immunology 1995;32(12):909-17.
1995: Kershaw M H; Trapani J A; Smyth M J
Cytotoxic lymphocytes: redirecting the cell-mediated immune response for the therapy of cancer.
Therapeutic immunology 1995;2(3):173-81.
1995: Smyth M J; McGuire M J; Thia K Y
Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6299-305.
1995: Smyth M J; Trapani J A
Granzymes: exogenous proteinases that induce target cell apoptosis.
Immunology today 1995;16(4):202-6.
1995: Smyth M J; Browne K A; Kinnear B F; Trapani J A; Warren H S
Distinct granzyme expression in human CD3- CD56+ large granular- and CD3- CD56+ small high density-lymphocytes displaying non-MHC-restricted cytolytic activity.
Journal of leukocyte biology 1995;57(1):88-93.
1995: Thia K Y; Jenkins N A; Gilbert D J; Copeland N G; Smyth M J
The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10.
Immunogenetics 1995;41(1):47-9.
1995: Smyth M J; Hulett M D; Thia K Y; Young H A; Sayers T J; Carter C R; Trapani J A
Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences.
Immunogenetics 1995;42(2):101-11.
1994: Trapani J A; Smyth M J; Apostolidis V A; Dawson M; Browne K A
Granule serine proteases are normal nuclear constituents of natural killer cells.
The Journal of biological chemistry 1994;269(28):18359-65.
1994: Smyth M J; Kershaw M H; Hulett M D; McKenzie I F; Trapani J A
Use of the 5'-flanking region of the mouse perforin gene to express human Fc gamma receptor I in cytotoxic T lymphocytes.
Journal of leukocyte biology 1994;55(4):514-22.
1994: Sayers T J; Wiltrout T A; Smyth M J; Ottaway K S; Pilaro A M; Sowder R; Henderson L E; Sprenger H; Lloyd A R
Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2289-97.
1994: Smyth M J; Browne K A; Thia K Y; Apostolidis V A; Kershaw M H; Trapani J A
Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis.
Clinical and experimental pharmacology & physiology 1994;21(1):67-70.
1993: Thia K Y; Smyth M J; Trapani J A
Expression of human perforin in a mouse cytotoxic T lymphocyte cell line: evidence for perturbation of granule-mediated cytotoxicity.
Journal of leukocyte biology 1993;54(6):528-33.
1993: Smyth M J; Sayers T J; Wiltrout T; Powers J C; Trapani J A
Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6195-205.
1993: Trapani J A; Browne K A; Dawson M; Smyth M J
Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody.
Biochemical and biophysical research communications 1993;195(2):910-20.
1993: Smyth M J; Ortaldo J R
Mechanisms of cytotoxicity used by human peripheral blood CD4+ and CD8+ T cell subsets. The role of granule exocytosis.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):740-7.
1992: Smyth M J; Wiltrout T; Trapani J A; Ottaway K S; Sowder R; Henderson L E; Kam C M; Powers J C; Young H A; Sayers T J
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia.
The Journal of biological chemistry 1992;267(34):24418-25.
1992: Smyth M J
Generation and cytotoxic profile of human peripheral blood CD4+ T lymphocytes.
Immunology and cell biology 1992;70 ( Pt 6)():379-90.
1992: Smyth M J
Mechanisms of cytotoxicity used by human peripheral blood T-cell subsets.
Transplantation proceedings 1992;24(5):2321-2.
1992: Sayers T J; Wiltrout T A; Sowder R; Munger W L; Smyth M J; Henderson L E
Purification of a factor from the granules of a rat natural killer cell line (RNK) that reduces tumor cell growth and changes tumor morphology. Molecular identity with a granule serine protease (RNKP-1).
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):292-300.

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