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George Smythe

Research Profile

Chemicals & Drugs

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Gas Chromatography-Mass Spectrometry

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TOP 3
Fei Song; Wei Wen; George A Smythe; Henry Brodaty; Barbara Cameron; John Crawford; Nicole A Kochan; Ora Lux; Karen Mather; Anne Poljak; Perminder S Sachdev
Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals.
Fei Song; Michael Valenzuela; Richard Mayeux; Anne Poljak; George A Smythe; Perminder S Sachdev
Meta-analysis of plasma amyloid-β levels in Alzheimer's disease.
Sarah E Coggan; George A Smythe; Ayse Bilgin; RS Grant
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.

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2012: Fei Song; Wei Wen; George A Smythe; Henry Brodaty; Barbara Cameron; John Crawford; Nicole A Kochan; Ora Lux; Karen Mather; Anne Poljak; Perminder S Sachdev
Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals.
PloS one 2012;7(6):e34078.
2011: Fei Song; Michael Valenzuela; Richard Mayeux; Anne Poljak; George A Smythe; Perminder S Sachdev
Meta-analysis of plasma amyloid-β levels in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;26(2):365-75.
2009: Sarah E Coggan; George A Smythe; Ayse Bilgin; RS Grant
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
Journal of neurochemistry 2009;108(5):1220-5.
2009: RS Grant; S E Coggan; George A Smythe
The physiological action of picolinic Acid in the human brain.
International journal of tryptophan research : IJTR 2009;2():71-9.
2008: Robert Owe-Young; Nicole L Webster; Muhammad Mukhtar; Roger J Pomerantz; George A Smythe; David Walker; Patricia J Armati; Suzanne M Crowe; Bruce J Brew
Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity.
Journal of neurochemistry 2008;105(4):1346-57.
2007: Gilles GUILLEMIN; Karen M Cullen; Chai K Lim; George A Smythe; Brett Garner; Vimal Kapoor; Osamu Takikawa; Bruce J Brew
Characterization of the kynurenine pathway in human neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(47):12884-92.
2007: T Jayasena; RS Grant; N Keerthisinghe; I Solaja; George A Smythe
Membrane permeability of redox active metal chelators: an important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells.
Neuroscience research 2007;57(3):454-61.
2007: Chutima Matayatsuk; Anne Poljak; Sonia Bustamante; George A Smythe; Ruchaneekorn W Kalpravidh; Pornpan Sirankapracha; Suthat Fucharoen; Prapon Wilairat
Quantitative determination of ortho- and meta-tyrosine as biomarkers of protein oxidative damage in beta-thalassemia.
Redox report : communications in free radical research 2007;12(5):219-28.
2006: Anne Poljak; Ross Grant; Chris J D Austin; Joanne F Jamie; Robert Willows; Osamu Takikawa; Tamantha K Littlejohn; Roger J W Truscott; Mark J Walker; Perminder Sachdev; George A Smythe
Inhibition of indoleamine 2,3 dioxygenase activity by H2O2.
Archives of biochemistry and biophysics 2006;450(1):9-19.
2005: Olgar Braga; George A Smythe; Andrea I Schäfer; Andrew J Feitz
Steroid estrogens in ocean sediments.
Chemosphere 2005;61(6):827-33.
2005: Catherine J Clark; Gillian M Mackay; George A Smythe; Sonia Bustamante; Trevor W Stone; R Stephen Phillips
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.
Infection and immunity 2005;73(8):5249-51.
2005: Olgar Braga; George A Smythe; Andrea I Schäfer; Andrew J Feitz
Fate of steroid estrogens in Australian inland and coastal wastewater treatment plants.
Environmental science & technology 2005;39(9):3351-8.
2005: Olgar Braga; George A Smythe; A I Schafer; Andrew J Feitz
Steroid estrogens in primary and tertiary wastewater treatment plants.
Water science and technology : a journal of the International Association on Water Pollution Research 2005;52(8):273-8.
2005: Gilles GUILLEMIN; George A Smythe; Osamu Takikawa; Bruce J Brew
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.
Glia 2005;49(1):15-23.
2004: Anne Poljak; Catriona A McLean; Perminder Sachdev; Henry Brodaty; George A Smythe
Quantification of hemorphins in Alzheimer's disease brains.
Journal of neuroscience research 2004;75(5):704-14.
2003: Gilles GUILLEMIN; George A Smythe; Laura A Veas; Osamu Takikawa; Bruce J Brew
A beta 1-42 induces production of quinolinic acid by human macrophages and microglia.
Neuroreport 2003;14(18):2311-5.
2003: George A Smythe; Anne Poljak; Sonia Bustamante; Olgar Braga; Alison Maxwell; Ross Grant; Perminder Sachdev
ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue.
Advances in experimental medicine and biology 2003;527():705-12.
2003: Gilles GUILLEMIN; Kieran R Williams; Danielle G Smith; George A Smythe; Juliana Croitoru-Lamoury; Bruce J Brew
Quinolinic acid in the pathogenesis of Alzheimer's disease.
Advances in experimental medicine and biology 2003;527():167-76.
2003: Gilles GUILLEMIN; Danielle G Smith; George A Smythe; Patricia J Armati; Bruce J Brew
Expression of the kynurenine pathway enzymes in human microglia and macrophages.
Advances in experimental medicine and biology 2003;527():105-12.
2003: Xiaosuo Wang; Vimal Kapoor; George A Smythe
Extraction and chromatography-mass spectrometric analysis of the active principles from selected Chinese herbs and other medicinal plants.
The American journal of Chinese medicine 2003;31(6):927-44.
2003: Anne Poljak; Ian W Dawes; Benno A Ingelse; Mark W Duncan; George A Smythe; Chris M Grant
Oxidative damage to proteins in yeast cells exposed to adaptive levels of H(2)O(2).
Redox report : communications in free radical research 2003;8(6):371-7.
2003: Xiaosuo Wang; George A Smythe
Assessment of hydroxyl radical generation and radical scavenging activity of Chinese medicinal herbs using GC-MS.
Redox report : communications in free radical research 2003;8(4):223-8.
2002: George A Smythe; Olgar Braga; Bruce J Brew; RS Grant; Gilles GUILLEMIN; Stephen J Kerr; D W Walker
Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry.
Analytical biochemistry 2002;301(1):21-6.
2002: George A Smythe; Gabrijela Matanovic
Specific analysis of nitrate and nitrite by gas chromatography/mass spectrometry.
Methods in enzymology 2002;359():148-57.
2001: Gilles GUILLEMIN; Stephen J Kerr; Louise Pemberton; Danielle G Smith; George A Smythe; Patricia J Armati; Bruce J Brew
IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(12):1097-101.
2001: Gilles GUILLEMIN; Stephen J Kerr; George A Smythe; Danielle G Smith; V Kapoor; Patricia J Armati; J Croitoru; Bruce J Brew
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection.
Journal of neurochemistry 2001;78(4):842-53.
2001: Danielle G Smith; Gilles GUILLEMIN; Louise Pemberton; S Kerr; Avindra Nath; George A Smythe; Bruce J Brew
Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat.
Journal of neurovirology 2001;7(1):56-60.
2000: D Yi; Benno A Ingelse; Mark W Duncan; George A Smythe
Quantification of 3-nitrotyrosine in biological tissues and fluids: generating valid results by eliminating artifactual formation.
Journal of the American Society for Mass Spectrometry 2000;11(6):578-86.
2000: Gilles GUILLEMIN; Danielle G Smith; Stephen J Kerr; George A Smythe; V Kapoor; Patricia J Armati; Bruce J Brew
Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis.
Redox report : communications in free radical research 2000;5(2-3):108-11.
1999: RS Grant; Robert J Passey; Gabrijela Matanovic; George A Smythe; Vimal Kapoor
Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?
Archives of biochemistry and biophysics 1999;372(1):1-7.
1999: Gilles GUILLEMIN; Stephen J Kerr; George A Smythe; Patricia J Armati; Bruce J Brew
Kynurenine pathway metabolism in human astrocytes.
Advances in experimental medicine and biology 1999;467():125-31.
1999: George A Smythe; Gabrijela Matanovic; D Yi; Mark W Duncan
Trifluoroacetic anhydride-catalyzed nitration of toluene as an approach to the specific analysis of nitrate by gas chromatography-mass spectrometry.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1999;3(1):67-74.
1997: Stephen J Kerr; Patricia J Armati; Louise Pemberton; George A Smythe; Bruce Tattam; Bruce J Brew
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.
Neurology 1997;49(6):1671-81.
1997: Louise Pemberton; Stephen J Kerr; George A Smythe; Bruce J Brew
Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(10):589-95.
1997: D Yi; George A Smythe; B C Blount; Mark W Duncan
Peroxynitrite-mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometry.
Archives of biochemistry and biophysics 1997;344(2):253-9.
1997: A Cerpa-Poljak; J Lahnstein; K E Mason; George A Smythe; Mark W Duncan
Mass spectrometric identification and quantification of hemorphins extracted from human adrenal and pheochromocytoma tissue.
Journal of neurochemistry 1997;68(4):1712-9.
1993: P E Graham; George A Smythe; G A Edwards; L Lazarus
Laboratory diagnosis of phaeochromocytoma: which analytes should we measure?
Annals of clinical biochemistry 1993;30 ( Pt 2)():129-34.
1992: M Gotoh; George A Smythe
Effects of intracerebroventricularly administered neostigmine on hypothalamic monoaminergic neuronal activities in awake rats.
Brain research 1992;586(2):340-3.
1992: Philip B Mitchell; George A Smythe
Elevated cortisol concentrations and the diminished prolactin response to fenfluramine.
The American journal of psychiatry 1992;149(6):851-2.
1992: G A Edwards; George A Smythe; P E Graham; L Lazarus
The impact of recent advances in diagnostic technology on the clinical presentation of phaeochromocytoma.
The Medical journal of Australia 1992;156(3):153-7.
1992: M Gotoh; George A Smythe; A Iguchi
Relationship between hypothalamic noradrenergic activity and the sympathetic activity in interscapular brown adipose tissue after cold-swim stress in rats.
Life sciences 1992;51(13):1057-63.
1991: Philip B Mitchell; George A Smythe
Endocrine and amine responses to D,L-fenfluramine in normal subjects.
Psychiatry research 1991;39(2):141-53.
1991: W S Pascoe; George A Smythe; Len Storlien
Enhanced responses to stress induced by fat-feeding in rats: relationship between hypothalamic noradrenaline and blood glucose.
Brain research 1991;550(2):192-6.
1991: M Gotoh; George A Smythe
Effects of intracerebroventricularly administered neostigmine on sympathetic neural activities of peripheral tissues in rats.
Brain research 1991;548(1-2):326-8.
1991: Philip Mitchell; George A Smythe; Gordon Parker; Kay Wilhelm; Henry Brodaty; P Boyce; I Hickie
Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls.
Psychiatry research 1991;37(2):179-93.
1990: L J Holmes; Len Storlien; George A Smythe
Medial basal hypothalamic monoamine activity associated with intracerebroventricular p-chlorophenylalanine-induced hyperphagia.
Brain research 1990;528(2):269-72.
1990: Philip Mitchell; George A Smythe; Gordon Parker; Kay Wilhelm; I Hickie; Henry Brodaty; P Boyce
Hormonal responses to fenfluramine in depressive subtypes.
The British journal of psychiatry : the journal of mental science 1990;157():551-7.
1990: Philip Mitchell; George A Smythe
Hormonal responses to fenfluramine in depressed and control subjects.
Journal of affective disorders 1990;19(1):43-51.
1989: W S Pascoe; George A Smythe; Len Storlien
2-deoxy-D-glucose-induced hyperglycemia: role for direct sympathetic nervous system activation of liver glucose output.
Brain research 1989;505(1):23-8.
1989: L J Holmes; George A Smythe; Len Storlien
Monoaminergic activity at the level of the hypothalamus and striatum: relationship to anticipated feeding and pancreatic insulin responses.
Brain research 1989;496(1-2):204-10.
1989: L J Holmes; Len Storlien; George A Smythe
Hypothalamic monoamines associated with the cephalic phase insulin response.
The American journal of physiology 1989;256(2 Pt 1):E236-41.
1989: George A Smythe; W S Pascoe; Len Storlien
Hypothalamic noradrenergic and sympathoadrenal control of glycemia after stress.
The American journal of physiology 1989;256(2 Pt 1):E231-5.
1988: Mark W Duncan; P Compton; L Lazarus; George A Smythe
Measurement of norepinephrine and 3,4-dihydroxyphenylglycol in urine and plasma for the diagnosis of pheochromocytoma.
The New England journal of medicine 1988;319(3):136-42.
1988: George A Smythe; R M Gleeson; B M Stead
Mechanisms of 5-hydroxy-L-tryptophan-induced adrenocorticotropin release: a major role for central noradrenergic drive.
Neuroendocrinology 1988;47(5):389-97.
1987: Philip B Mitchell; George A Smythe
Growth hormone response to clonidine in depression.
The American journal of psychiatry 1987;144(5):690-1.
1986: H S Grunstein; R M Gleeson; George A Smythe
Relationship between hypothalamic noradrenergic neuronal activity and serum 3-methoxy-4-hydroxyphenylethylene glycol in the rat.
Life sciences 1986;39(3):207-13.
1986: H S Grunstein; George A Smythe; J E Bradshaw; P J Compton
Tolbutamide increases hypothalamic serotonin activity in the rat.
Diabetes 1986;35(4):475-80.
1985: W D Myers; K T Ng; G Singer; George A Smythe; Mark W Duncan
Dopamine and salsolinol levels in rat hypothalami and striatum after schedule-induced self-injection (SISI) of ethanol and acetaldehyde.
Brain research 1985;358(1-2):122-8.
1985: George A Smythe; J E Bradshaw; M V Nicholson; H S Grunstein; L H Storlien
Rapid bidirectional effects of insulin on hypothalamic noradrenergic and serotoninergic neuronal activity in the rat: role in glucose homeostasis.
Endocrinology 1985;117(4):1590-7.
1985: George A Smythe; J E Bradshaw; R M Gleeson; M V Nicholson
Dopamine-beta-hydroxylase inhibition acutely stimulates rats hypothalamic noradrenaline and dopamine neuronal activity as assessed from metabolic ratios and circulating glucose and ACTH responses.
Life sciences 1985;37(9):841-7.
1985: L H Storlien; H S Grunstein; George A Smythe
Guanethidine blocks the 2-deoxy-D-glucose-induced hypothalamic noradrenergic drive to hyperglycemia.
Brain research 1985;335(1):144-7.
1985: George A Smythe; J E Bradshaw; R M Gleeson; H S Grunstein; M V Nicholson
The central vs. peripheral effects of clonidine on ACTH, corticosterone and glucose release.
European journal of pharmacology 1985;111(3):401-3.
1985: Mark W Duncan; George A Smythe; P S Clezy
Gas chromatographic/mass spectrometric methodology for simultaneous assay of salsolinol, dopamine, norepinephrine, dihydroxyphenylacetic acid and dihydroxyphenylethanol.
Biomedical mass spectrometry 1985;12(3):106-14.
1985: H S Grunstein; D E James; L H Storlien; George A Smythe; Edward Kraegen
Hyperinsulinemia suppresses glucose utilization in specific brain regions: in vivo studies using the euglycemic clamp in the rat.
Endocrinology 1985;116(2):604-10.
1985: W D Myers; L Mackenzie; K T Ng; G Singer; George A Smythe; Mark W Duncan
Salsolinol and dopamine in rat medial basal hypothalamus after chronic ethanol exposure.
Life sciences 1985;36(4):309-14.
1984: George A Smythe; H S Grunstein; J E Bradshaw; M V Nicholson; P J Compton
Relationships between brain noradrenergic activity and blood glucose.
Nature 1984;308(5954):65-7.
1983: George A Smythe; J E Bradshaw; R F Vining
Hypothalamic monoamine control of stress-induced adrenocorticotropin release in the rat.
Endocrinology 1983;113(3):1062-71.
1983: George A Smythe; Mark W Duncan; J E Bradshaw; M V Nicholson
Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline and yohimbine on hypothalamic monoamine status and pituitary hormone release in the rat.
Australian journal of biological sciences 1983;36(4):379-86.
1983: George A Smythe; J E Bradshaw
Different acute effects of the tyrosine hydroxylase inhibitors alpha-methyl-p-tyrosine and 3-iodo-L-tyrosine on hypothalamic noradrenaline activity and adrenocorticotrophin release in the rat.
Australian journal of biological sciences 1983;36(5-6):519-23.
1982: George A Smythe; J E Bradshaw; W Y Cai; R G Symons
Hypothalamic serotoninergic stimulation of thyrotropin secretion and related brain-hormone and drug interactions in the rat.
Endocrinology 1982;111(4):1181-91.
1982: George A Smythe; Mark W Duncan; J E Bradshaw; W Y Cai
Serotoninergic control of growth hormone secretion: hypothalamic dopamine, norepinephrine, and serotonin levels and metabolism in three hyposomatotropic rat models and in normal rats.
Endocrinology 1982;110(2):376-83.
1982: George A Smythe; J E Bradshaw; M Duncan
Loss of hypothalamic dopaminergic control of prolactin secretion in the hyperprolactinaemic rat.
Australian journal of biological sciences 1982;35(2):207-13.