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Christopher Snyder

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Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Yuxiang Dong; Sergio Wittlin; Kamaraj Sriraghavan; Jacques Chollet; Susan A Charman; William N Charman; Christian Scheurer; Heinrich Urwyler; Josefina Santo Tomas; Christopher Snyder; Darren J Creek; Julia Morizzi; Maria Koltun; Hugues Matile; Xiaofang Wang; Maniyan Padmanilayam; Yuanqing Tang; Arnulf Dorn; Reto Brun; Jonathan L Vennerstrom
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Xiaofang Wang; Yuxiang Dong; Sergio Wittlin; Darren J Creek; Jacques Chollet; Susan A Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jonathan L Vennerstrom
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.

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All Publications

2013: Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Journal of medicinal chemistry 2013;56(6):2547-55.
2010: Yuxiang Dong; Sergio Wittlin; Kamaraj Sriraghavan; Jacques Chollet; Susan A Charman; William N Charman; Christian Scheurer; Heinrich Urwyler; Josefina Santo Tomas; Christopher Snyder; Darren J Creek; Julia Morizzi; Maria Koltun; Hugues Matile; Xiaofang Wang; Maniyan Padmanilayam; Yuanqing Tang; Arnulf Dorn; Reto Brun; Jonathan L Vennerstrom
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Journal of medicinal chemistry 2010;53(1):481-91.
2007: Xiaofang Wang; Yuxiang Dong; Sergio Wittlin; Darren J Creek; Jacques Chollet; Susan A Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jonathan L Vennerstrom
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
Journal of medicinal chemistry 2007;50(23):5840-7.
2007: Christopher Snyder; Jacques Chollet; Josefina Santo Tomas; Christian Scheurer; Sergio Wittlin
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
Experimental parasitology 2007;115(3):296-300.
2006: Yuxiang Dong; Yuanqing Tang; Jacques Chollet; Hugues Matile; Sergio Wittlin; Susan A Charman; William N Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Bernard Scorneaux; Saroj Bajpai; Scott A Alexander; Xiaofang Wang; Maniyan Padmanilayam; Srinivasa R Cheruku; Reto Brun; Jonathan L Vennerstrom
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
Bioorganic & medicinal chemistry 2006;14(18):6368-82.
2005: Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis C K Chiu; William N Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Journal of medicinal chemistry 2005;48(15):4953-61.