Patrício Soares-da-Silva

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Silva Elisabete; Soares-da-Silva Patrício
Protein cytoskeleton and overexpression of Na(+),K(+)-ATPase in opossum kidney cells.
Bonifácio Maria João; Loureiro Ana I; Torrão Leonel; Fernandes-Lopes Carlos; Wright Lyndon; Pinho Maria João; Soares-da-Silva Patrício
Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone.
Vaz da Silva Manuel; Costa Raquel; Soares Eva; Maia Joana; Falcão Amílcar; Almeida Luis; Soares da Silva Patrício
Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects.

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All Publications

2009: Silva Elisabete; Soares-da-Silva Patrício
Protein cytoskeleton and overexpression of Na(+),K(+)-ATPase in opossum kidney cells.
Journal of cellular physiology 2009;221(2):318-24.
2009: Bonifácio Maria João; Loureiro Ana I; Torrão Leonel; Fernandes-Lopes Carlos; Wright Lyndon; Pinho Maria João; Soares-da-Silva Patrício
Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone.
Biochemical pharmacology 2009;78(8):1043-51.
2009: Vaz da Silva Manuel; Costa Raquel; Soares Eva; Maia Joana; Falcão Amílcar; Almeida Luis; Soares da Silva Patrício
Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects.
Fundamental & clinical pharmacology 2009;23(4):509-14.
2009: Amaral João S; Pinho Maria João; Soares-da-Silva Patrício
Regulation of amino acid transporters in the rat remnant kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(7):2058-67.
2009: Almeida Luis; Vaz-da-Silva Manuel; Falcão Amílcar; Soares Eva; Costa Raquel; Loureiro Ana I; Fernandes-Lopes Carlos; Rocha José-Francisco; Nunes Teresa; Wright Lyndon; Soares-da-Silva Patrício
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers.
Molecular nutrition & food research 2009;53 Suppl 1():S7-15.
2009: Elger Christian; Halász Peter; Maia Joana; Almeida Luis; Soares-da-Silva Patrício;
Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study.
Epilepsia 2009;50(3):454-63.
2008: Vaz-da-Silva M; Loureiro A I; Falcao A; Nunes T; Rocha J-F; Fernandes-Lopes C; Soares E; Wright L; Almeida L; Soares-da-Silva P
Effect of food on the pharmacokinetic profile of trans-resveratrol.
International journal of clinical pharmacology and therapeutics 2008;46(11):564-70.
2008: Alves Gilberto; Figueiredo Isabel; Castel-Branco Margarida; Lourenço Nulita; Falcão Amílcar; Caramona Margarida; Soares-da-Silva Patrício
Disposition of eslicarbazepine acetate in the mouse after oral administration.
Fundamental & clinical pharmacology 2008;22(5):529-36.
2008: Almeida Luis; Falcão Amílcar; Vaz-da-Silva Manuel; Nunes Teresa; Santos Ana-Teresa; Rocha José-Francisco; Neta Carla; Macedo Tice; Fontes-Ribeiro C; Soares-da-Silva P
Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
European journal of clinical pharmacology 2008;64(10):961-6.
2008: Almeida Luis; Minciu Ioana; Nunes Teresa; Butoianu Nicolina; Falcão Amilcar; Magureanu Sandra-Adriana; Soares-da-Silva Patrício
Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy.
Journal of clinical pharmacology 2008;48(8):966-77.
2008: Simão Sónia; Fraga Sónia; Jose Pedro A; Soares-da-Silva Patrício
Oxidative stress plays a permissive role in alpha2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells.
Molecular and cellular biochemistry 2008;315(1-2):31-9.
2008: Almeida L; Falcão A; Vaz-da-Silva M; Coelho R; Albino-Teixeira A; Soares-da-Silva P
Personality characteristics of volunteers in Phase 1 studies and likelihood of reporting adverse events.
International journal of clinical pharmacology and therapeutics 2008;46(7):340-8.
2008: Simão Sónia; Pedrosa Rui; Hopfer Ulrich; Mount David B; Jose Pedro A; Soares-da-Silva Patrício
Short-term regulation of the Cl-/HCO3(-) exchanger in immortalized SHR proximal tubular epithelial cells.
Biochemical pharmacology 2008;75(11):2224-33.
2008: Amaral João S; Pinho Maria João; Soares-da-Silva Patrício
Genomic regulation of intestinal amino acid transporters by aldosterone.
Molecular and cellular biochemistry 2008;313(1-2):1-10.
2008: Almeida Luis; Kashdan Todd B; Nunes Teresa; Coelho Rui; Albino-Teixeira António; Soares-da-Silva Patrício
Who volunteers for phase I clinical trials? Influences of anxiety, social anxiety and depressive symptoms on self-selection and the reporting of adverse events.
European journal of clinical pharmacology 2008;64(6):575-82.
2008: Alves Gilberto; Figueiredo Isabel; Falcão Amílcar; Castel-Branco Margarida; Caramona Margarida; Soares-Da-Silva Patrício
Stereoselective disposition of S- and R-licarbazepine in mice.
Chirality 2008;20(6):796-804.
2008: Pedrosa Rui; Villar Van Anthony M; Pascua Annabelle M; Simão Sónia; Hopfer Ulrich; Jose Pedro A; Soares-da-Silva Patrício
H2O2 stimulation of the Cl-/HCO3- exchanger by angiotensin II and angiotensin II type 1 receptor distribution in membrane microdomains.
Hypertension 2008;51(5):1332-8.
2008: Simão S; Fraga S; Jose P A; Soares-da-Silva P
Oxidative stress and alpha1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells.
British journal of pharmacology 2008;153(7):1445-55.
2008: Maia J; Almeida L; Falcão A; Soares E; Mota F; Potgieter M A; Potgieter J H; Soares-da-Silva P
Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate.
International journal of clinical pharmacology and therapeutics 2008;46(3):119-30.
2008: Almeida L; Kashdan T B; Coelho R; Albino-Teixeira A; Soares-da-Silva P
Healthy subjects volunteering for Phase I studies: influence of curiosity, exploratory tendencies and perceived self-efficacy.
International journal of clinical pharmacology and therapeutics 2008;46(3):109-18.
2008: Almeida Luis; Potgieter J Hendrick; Maia Joana; Potgieter M Alida; Mota Fernando; Soares-da-Silva P
Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment.
European journal of clinical pharmacology 2008;64(3):267-73.
2008: Pinto Vanda; Pinho Maria João; Hopfer Ulrich; Jose Pedro A; Soares-da-Silva Patrício
Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.
Molecular and cellular biochemistry 2008;310(1-2):191-201.
2008: Ferreira Joaquim J; Almeida Luis; Cunha Luis; Ticmeanu Marina; Rosa Mário M; Januário Cristina; Mitu Cristina-Elena; Coelho Miguel; Correia-Guedes Leonor; Morgadinho Ana; Nunes Teresa; Wright Lyndon C; Falcão Amílcar; Sampaio Cristina; Soares-da-Silva Patrício
Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease.
Clinical neuropharmacology 2008;31(1):2-18.
2008: Fontes-Ribeiro Carlos; Macedo Tice; Nunes Teresa; Neta Carla; Vasconcelos Teófilo; Cerdeira Rui; Lima Ricardo; Rocha José-Francisco; Falcão Amílcar; Almeida Luís; Soares-da-Silva Patrício
Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: randomized, open-label, crossover, single-centre study in healthy volunteers.
Drugs in R&D 2008;9(6):447-54.
2008: Vaz-da-Silva Manuel; Loureiro Ana I; Nunes Teresa; Lopes Carlos; Rocha José; Machado Rita; Costa Raquel; Torrão Leonel; Falcão Amílcar; Wright Lyndon; Almeida Luis; Soares-da-Silva Patrício
Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects.
Drugs in R&D 2008;9(6):435-46.
2007: Pinho Maria João; Serrão Maria Paula; José Pedro A; Soares-da-Silva Patrício
Organ specific underexpression renal of Na+-dependent B0AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake.
Molecular and cellular biochemistry 2007;306(1-2):9-18.
2007: Almeida Luis; Azevedo Benedita; Nunes Teresa; Vaz-da-Silva Manuel; Soares-da-Silva Patrício
Why healthy subjects volunteer for phase I studies and how they perceive their participation?
European journal of clinical pharmacology 2007;63(11):1085-94.
2007: Silva Elisabete; Soares-da-Silva Patrício
Reactive oxygen species and the regulation of renal Na+-K+-ATPase in opossum kidney cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(4):R1764-70.
2007: Damasceno-Oliveira Alfredo; Fernández-Durán Begoña; Gonçalves José; Serrão Paula; Soares-da-Silva Patrício; Reis-Henriques Maria Armanda; Coimbra João
Effects of cyclic hydrostatic pressure on the brain biogenic amines concentrations in the flounder, Platichthys flesus.
General and comparative endocrinology 2007;153(1-3):385-9.
2007: Magro Fernando; Fraga Sónia; Soares-da-Silva Patrício
Short-term effect on intestinal epithelial Na(+)/H(+) exchanger by Gi(alpha1,2)-coupled 5-HT(1A) and G(q/11)-coupled 5-HT(2) receptors.
Life sciences 2007;81(7):560-9.
2007: Pinho Maria João; Pinto Vanda; Serrão Maria Paula; Jose Pedro A; Soares-da-Silva Patrício
Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(1):R538-47.
2007: Falcão Amílcar; Maia Joana; Almeida Luis; Mazur Dago; Gellert Manfred; Soares-da-Silva Patrício
Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker.
Biopharmaceutics & drug disposition 2007;28(5):249-56.
2007: Pedrosa Rui; Gonçalves Nuno; Hopfer Ulrich; Jose Pedro A; Soares-da-Silva Patrício
Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.
Hypertension 2007;49(5):1186-93.
2007: Pinho Maria João; Serrão Maria Paula; Soares-da-Silva Patrício
High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats.
American journal of physiology. Renal physiology 2007;292(5):F1452-63.
2007: Elger Christian; Bialer Meir; Cramer Joyce A; Maia Joana; Almeida Luis; Soares-da-Silva Patrício
Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures.
Epilepsia 2007;48(3):497-504.
2007: Almeida Luis; Soares-da-Silva Patrício
Eslicarbazepine acetate (BIA 2-093).
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007;4(1):88-96.
2007: Bonifácio Maria João; Palma P Nuno; Almeida Luís; Soares-da-Silva Patrício
Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.
CNS drug reviews 2007;13(3):352-79.
2007: Pinho Maria João; Serrão Maria Paula; Jose Pedro A; Soares-da-Silva Patrício
Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(5):535-48.
2006: Magro F; Cunha E; Araujo F; Meireles E; Pereira P; Dinis-Ribeiro M; Veloso F Tavarela; Medeiros R; Soares-da-Silva P
Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment.
Digestive diseases and sciences 2006;51(11):2039-44.
2006: Loureiro A I; Bonifácio M J; Fernandes-Lopes C; Almeida L; Wright L C; Soares-Da-Silva P
Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(11):1856-62.
2006: Palma P N; Rodrigues M L; Archer M; Bonifácio M J; Loureiro A I; Learmonth D A; Carrondo M A; Soares-da-Silva P
Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation.
Molecular pharmacology 2006;70(1):143-53.
2006: Silva E; Gomes P; Soares-da-Silva P
Increases in transepithelial vectorial Na+ transport facilitates Na+-dependent L-DOPA transport in renal OK cells.
Life sciences 2006;79(8):723-9.
2006: Gomes Pedro; Soares-da-Silva Patrício
Upregulation of apical NHE3 in renal OK cells overexpressing the rodent alpha(1)-subunit of the Na(+) pump.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(4):R1142-50.
2006: Magro F; Fraga S; Azevedo I; Soares-da-Silva P
Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis.
Digestive diseases and sciences 2006;51(3):495-501.
2006: Beliaev Alexandre; Learmonth David A; Soares-da-Silva Patricio
Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.
Journal of medicinal chemistry 2006;49(3):1191-7.
2006: Bek Martin J; Wang Xiaoyan; Asico Laureano D; Jones John E; Zheng Shaopeng; Li Xiaoxi; Eisner Gilbert M; Grandy David K; Carey Robert M; Soares-da-Silva Patricio; Jose Pedro A
Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice.
Hypertension 2006;47(2):288-95.
2006: Silva E; Gomes P; Soares-da-Silva P
Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing.
The Journal of membrane biology 2006;212(3):163-75.
2006: Fraga Sónia; Luo Yingjin; Jose Pedro; Zandi-Nejad Kambiz; Mount David B; Soares-da-Silva Patrício
Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6).
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;18(6):347-60.
2005: Learmonth David A; Bonifácio Maria João; Soares-da-Silva Patrício
Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase.
Journal of medicinal chemistry 2005;48(25):8070-8.
2005: Magro Fernando; Fraga Sónia; Soares-da-Silva Patrício
Interferon-gamma-induced STAT1-mediated membrane retention of NHE1 and associated proteins ezrin, radixin and moesin in HT-29 cells.
Biochemical pharmacology 2005;70(9):1312-9.
2005: Soares-da-Silva P; Serrão M P
Apical and basolateral 4F2hc and the amino acid exchange of L-DOPA in renal LLC-PK1 cells.
Amino acids 2005;29(3):213-9.
2005: Fraga S; Pinho M J; Soares-da-Silva P
Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells.
Amino acids 2005;29(3):229-33.
2005: Soares-da-Silva P; Serrão P; Fraga S; Pinho M J
Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK.
Acta physiologica Scandinavica 2005;185(1):71-8.
2005: Almeida Luis; Falcão Amílcar; Maia Joana; Mazur Dago; Gellert Manfred; Soares-da-Silva Patrício
Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects.
Journal of clinical pharmacology 2005;45(9):1062-6.
2005: Magro Fernando; Fraga Sónia; Soares-da-Silva Patrício
Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma.
British journal of pharmacology 2005;145(1):93-103.
2005: Magina S; Santos J; Coroas A; Oliveira J G; Serrão P; Soares-Da-Silva P; Resende C; Pestana M
Salt sensitivity of blood pressure in patients with psoriasis on ciclosporin therapy.
The British journal of dermatology 2005;152(4):773-6.
2005: Alvelos Margarida; Ferreira António; Bettencourt Paulo; Pimenta Joana; Azevedo Ana; Serrão Paula; Rocha-Gonçalves Francisco; Soares-da-Silva Patrício
Effect of saline load and metoclopramide on the renal dopaminergic system in patients with heart failure and healthy controls.
Journal of cardiovascular pharmacology 2005;45(3):197-203.
2005: Magro F; Fraga S; Ribeiro T; Soares-da-Silva P
Regional intestinal adaptations in Na+,K+-ATPase in experimental colitis and the contrasting effects of interferon-gamma.
Acta physiologica Scandinavica 2005;183(2):191-9.
2005: Rodrigues M L; Bonifácio M J; Soares-da-Silva P; Carrondo M A; Archer M
Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 1):118-20.
2005: Vaz-da-Silva Manuel; Loureiro Ana I; Nunes Teresa; Maia Joana; Tavares Susana; Falcão Amilcar; Silveira Pedro; Almeida Luis; Soares-da-Silva Patricio
Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions.
Clinical drug investigation 2005;25(6):391-9.
2005: Fontes-Ribeiro Carlos; Nunes Teresa; Falcão Amilcar; Neta Carla; Lima Ricardo; Tavares Susana; Almeida Luis; Macedo Tice; Soares-da-Silva Patricio
Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations.
Drugs in R&D 2005;6(5):253-60.
2005: Maia Joana; Vaz-da-Silva Manuel; Almeida Luis; Falcão Amilcar; Silveira Pedro; Guimarães Serafim; Graziela Patricia; Soares-da-Silva Patricio
Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093).
Drugs in R&D 2005;6(4):201-6.
2005: Rebola Nelson; Porciúncula Lisiane O; Lopes Luísa V; Oliveira Catarina R; Soares-da-Silva Patrício; Cunha Rodrigo A
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.
Epilepsia 2005;46 Suppl 5():159-65.
2004: Araújo Inês M; Ambrósio António Francisco; Leal Ermelindo C; Verdasca Maria João; Malva João Oliveira; Soares-da-Silva Patrício; Carvalho Arsélio Pato; Carvalho Caetana Monteiro
Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093.
Epilepsia 2004;45(12):1498-505.
2004: Learmonth David A; Palma P Nuno; Vieira-Coelho Maria A; Soares-da-Silva Patrício
Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase.
Journal of medicinal chemistry 2004;47(25):6207-17.
2004: Pedrosa Rui; Gomes Pedro; Hopfer Ulrich; Jose Pedro A; Soares-da-Silva Patrício
Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.
American journal of physiology. Renal physiology 2004;287(5):F1059-66.
2004: Soares-Da-Silva Patrício; Serrão Maria Paula; Pinho Maria João; Bonifácio Maria João
Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1489-98.
2004: Fraga Sónia; Jose Pedro A; Soares-da-Silva Patrício
Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(4):R772-9.
2004: Alvelos Margarida; Ferreira António; Bettencourt Paulo; Serrão Paula; Pestana Manuel; Cerqueira-Gomes Mário; Soares-Da-Silva Patrício
The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2004;6(5):593-9.
2004: Almeida Luis; Soares-da-Silva Patrício
Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans.
Journal of clinical pharmacology 2004;44(8):906-18.
2004: Magro Fernando; Fraga Sónia; Ribeiro Tomé; Soares-da-Silva Patrício
Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation.
British journal of pharmacology 2004;142(8):1281-92.
2004: Soares-da-Silva Patrício; Serrão Maria Paula
High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.
American journal of physiology. Renal physiology 2004;287(2):F252-61.
2004: Pedrosa Rui; Gomes Pedro; Zeng Chunyu; Hopfer Ulrich; Jose Pedro A; Soares-da-Silva Patrício
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
British journal of pharmacology 2004;142(8):1343-53.
2004: Pinho Maria João; Serrão Maria Paula; Gomes Pedro; Hopfer Ulrich; Jose Pedro A; Soares-da-Silva P
Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells.
Kidney international 2004;66(1):216-26.
2004: Pedrosa Rui; Jose Pedro A; Soares-da-Silva P
Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells.
American journal of physiology. Renal physiology 2004;286(6):F1120-6.
2004: Magro F; Fraga S; Ribeiro T; Soares-da-Silva P
Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake.
Acta physiologica Scandinavica 2004;180(4):379-86.
2004: Gomes Pedro; Soares-da-Silva Patrício
Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades.
European journal of pharmacology 2004;488(1-3):51-9.
2004: Almeida Luis; Vaz-da-Silva Manuel; Silveira Pedro; Falcão Amilcar; Maia Joana; Loureiro Ana; Torrão Leonel; Machado Rita; Wright Lyndon; Soares-da-Silva Patrício
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa.
Clinical neuropharmacology 2004;27(1):17-24.
2004: Pedrosa Rui; Gomes Pedro; Soares-da-Silva Patricío
Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2004;14(1-2):91-100.
2004: Pestana Manuel; Santos Joana; Santos Alejandro; Coroas Andreia; Correia Flora; Serrão Paula; Valbuena Carmen; Soares-da-Silva Patrício
Renal dopamine and salt sensitivity of blood pressure in IgA nephropathy.
Kidney & blood pressure research 2004;27(2):78-87.
2003: Almeida Luis; Soares-da-Silva Patrício
Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjects.
Journal of clinical pharmacology 2003;43(12):1350-60.
2003: Silveira Pedro; Vaz-da-Silva Manuel; Almeida Luis; Maia Joana; Falcão Amilcar; Loureiro Ana; Torrão Leonel; Machado Rita; Wright Lyndon; Soares-da-Silva Patrício
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
European journal of clinical pharmacology 2003;59(8-9):603-9.
2003: Pinho Maria João; Gomes Pedro; Serrão Maria Paula; Bonifácio Maria João; Soares-da-Silva Patrício
Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension.
Hypertension 2003;42(4):613-8.
2003: Rebola Nelson; Coelho Joana E; Costenla Ana Rita; Lopes Luísa V; Parada António; Oliveira Catarina R; Soares-da-Silva Patrício; de Mendonça Alexandre; Cunha Rodrigo A
Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats.
The European journal of neuroscience 2003;18(4):820-8.
2003: Guimarães J T; Vindis C; Soares-da-Silva P; Parini A
Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex.
Life sciences 2003;73(8):955-67.
2003: Soares-da-Silva Patrício; Vieira-Coelho Maria A; Parada António
Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone).
Pharmacology & toxicology 2003;92(6):272-8.
2003: Parada António; Soares-da-Silva Patrício
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain.
Pharmacology 2003;68(1):29-37.
2003: Gomes Pedro; Soares-da-Silva Patrício
Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells.
British journal of pharmacology 2003;138(5):968-76.
2003: Palma P N; Bonifácio M J; Loureiro A I; Wright L C; Learmonth D A; Soares-da-Silva P
Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):250-8.
2003: Bonifácio Maria João; Vieira-Coelho Maria Augusta; Soares-da-Silva Patrício
Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor.
European journal of pharmacology 2003;460(2-3):163-70.
2003: Almeida Luis; Soares-da-Silva Patrício
Safety, tolerability and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic agent, during first administration to humans.
Drugs in R&D 2003;4(5):269-84.
2003: Almeida Luis; Soares-da-Silva Patrício
Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans.
Drugs in R&D 2003;4(4):207-17.
2003: Bonifácio Maria João; Soares-da-Silva Patrício
Purification of membrane-bound catechol-O-methyltransferase.
Methods in molecular biology (Clifton, N.J.) 2003;228():231-8.
2002: Hollon Tom R; Bek Martin J; Lachowicz Jean E; Ariano Marjorie A; Mezey Eva; Ramachandran Ramesh; Wersinger Scott R; Soares-da-Silva Patricio; Liu Zhi Fang; Grinberg Alexander; Drago John; Young W Scott; Westphal Heiner; Jose Pedro A; Sibley David R
Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10801-10.
2002: Pedrosa R; Soares-da-Silva P
Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine.
British journal of pharmacology 2002;137(8):1305-13.
2002: Andrinolo Darío; Gomes Pedro; Fraga Sonia; Soares-da-Silva Patrício; Lagos Néstor
Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliums.
Toxicon : official journal of the International Society on Toxinology 2002;40(10):1389-97.
2002: Bonifácio Maria João; Archer Margarida; Rodrigues Maria L; Matias Pedro M; Learmonth David A; Carrondo Maria Arménia; Soares-Da-Silva Patrício
Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application.
Molecular pharmacology 2002;62(4):795-805.
2002: Lucas-Teixeira V A; Hussain T; Serrão P; Soares-da-Silva P; Lokhandwala M F
Intestinal dopaminergic activity in obese and lean Zucker rats: response to high salt intake.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2002;24(5):383-96.
2002: Gomes Pedro; Soares-Da-Silva P
D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.
American journal of physiology. Renal physiology 2002;283(1):F114-23.
2002: Gomes Pedro; Xu Jing; Serrão Paula; Dória Sofia; Jose Pedro A; Soares-da-Silva Patrício
Expression and function of sodium transporters in two opossum kidney cell clonal sublines.
American journal of physiology. Renal physiology 2002;283(1):F73-85.
2002: Fraga S; Sampaio-Maia B; Serrão M P; Soares-da-Silva P
Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells.
Acta physiologica Scandinavica 2002;175(2):103-11.
2002: Gomes P; Soares-da-Silva P
Dopamine-induced inhibition of Na+-K+-ATPase activity requires integrity of actin cytoskeleton in opossum kidney cells.
Acta physiologica Scandinavica 2002;175(2):93-101.
2002: Gomes Pedro; Soares-da-Silva P
Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity.
American journal of physiology. Renal physiology 2002;282(6):F1084-96.
2002: Fraga Sónia; Serrão Maria Paula; Soares-da-Silva Patrício
The L-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger.
European journal of pharmacology 2002;441(3):127-35.
2002: Fraga S; Serrão M P; Soares-da-Silva Patricio
L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids.
The Journal of nutrition 2002;132(4):733-8.
2002: Gomes P; Soares-da-Silva P
Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines.
The Journal of membrane biology 2002;186(2):63-80.
2002: Ferreira António; Bettencourt Paulo; Pimenta Joana; Friões Fernando; Pestana Manuel; Soares-da-Silva Patrício; Cerqueira-Gomes Mário
The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure.
American heart journal 2002;143(3):391-7.
2002: Ambrósio António F; Soares-Da-Silva Patrício; Carvalho Caetana M; Carvalho Arsélio P
Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.
Neurochemical research 2002;27(1-2):121-30.
2002: Hainzl D; Loureiro A I; Parada A; Soares-da-silva P
Metabolism of 10,11-dihydro-10-hydroxyimino-5H-dibenz/b, f/azepine-5-carboxamide, a potent anti-epileptic drug.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(2):131-40.
2002: Magro F; Vieira-Coelho M A; Fraga S; Serrão M P; Veloso F Tavarela; Ribeiro Tomé; Soares-da-Silva P
Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease.
Digestive diseases and sciences 2002;47(1):216-24.
2002: Gomes Pedro; Soares-da-Silva Patrício
Na(+)/H(+) exchanger activity and dopamine D(1)-like receptor function in two opossum kidney cell clonal sublines.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2002;12(5-6):259-68.
2001: Bonifácio M J; Vieira-Coelho M A; Soares-da-Silva P
Expression and characterization of rat soluble catechol-O-methyltransferase fusion protein.
Protein expression and purification 2001;23(1):106-12.
2001: Vieira-Coelho M A; Soares-da-Silva P
Comparative study on sodium transport and Na+,K+-ATPase activity in Caco-2 and rat jejunal epithelial cells: effects of dopamine.
Life sciences 2001;69(17):1969-81.
2001: Vieira-Coelho M A; Serrão P; Hussain T; Lokhandwala M F; Soares-da-Silva P
Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats.
Life sciences 2001;69(17):1957-68.
2001: Ferreira A; Bettencourt P; Pestana M; Correia F; Serrão P; Martins L; Cerqueira-Gomes M; Soares-Da-Silva P
Heart failure, aging, and renal synthesis of dopamine.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(3):502-9.
2001: Gomes P; Vieira-Coelho M A; Soares-Da-Silva P
Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na(+)/H(+) exchanger.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(1):R10-8.
2001: Rodrigues M L; Archer M; Bonifácio M J; Soares-da-Silva P; Carrondo M A
Crystallization and preliminary crystallographic characterization of catechol-O-methyltransferase in complex with its cosubstrate and an inhibitor.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 6):906-8.
2001: Parada A; Loureiro A I; Vieira-Coelho M A; Hainzl D; Soares-da-Silva P
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
European journal of pharmacology 2001;420(1):27-32.
2001: Bonifácio M J; Sheridan R D; Parada A; Cunha R A; Patmore L; Soares-da-Silva P
Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine.
Epilepsia 2001;42(5):600-8.
2001: Hainzl D; Parada A; Soares-da-Silva P
Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine.
Epilepsy research 2001;44(2-3):197-206.
2001: Ambrósio A F; Silva A P; Malva J O; Soares-da-Silva P; Carvalho A P; Carvalho C M
Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels.
Biochemical pharmacology 2001;61(10):1271-5.
2001: Vieira-Coelho M A; Gomes P; Serrão M P; Soares-da-Silva P
D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors.
Kidney international 2001;59(5):1683-94.
2001: Ferreira A; Bettencourt P; Dias P; Pestana M; Serrão P; Soares-da-Silva P; Cerqueira-Gomes M
Neurohormonal activation, the renal dopaminergic system and sodium handling in patients with severe heart failure under vasodilator therapy.
Clinical science (London, England : 1979) 2001;100(5):557-66.
2001: Learmonth D A; Benes J; Parada A; Hainzl D; Beliaev A; Bonifácio M J; Matias P M; Carrondo M A; Garrett J; Soares-da-Silva P
Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives.
European journal of medicinal chemistry 2001;36(3):227-36.
2001: Sampaio-Maia B; Serrão M P; Soares-da-Silva P
Regulatory pathways and uptake of L-DOPA by capillary cerebral endothelial cells, astrocytes, and neuronal cells.
American journal of physiology. Cell physiology 2001;280(2):C333-42.
2001: Pestana M; Jardim H; Correia F; Vieira-Coelho M A; Soares-da-Silva P
Renal dopaminergic mechanisms in renal parenchymal diseases and hypertension.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16 Suppl 1():53-9.
2001: Sampaio-Maia B; Soares-Da-Silva P
Inhibition of calcium-independent luminal uptake of L-dopa by calmodulin antagonists in immortalized rat capillary cerebral endothelial cells.
Cell biology international 2001;25(3):245-52.
2000: Bonifácio M J; Vieira-Coelho M A; Borges N; Soares-da-Silva P
Kinetics of rat brain and liver solubilized membrane-bound catechol-O-methyltransferase.
Archives of biochemistry and biophysics 2000;384(2):361-7.
2000: Vieira-Coelho M A; Serrão P; Guimarães J T; Pestana M; Soares-da-Silva P
Concerted action of dopamine on renal and intestinal Na(+)-K(+)-ATPase in the rat remnant kidney.
American journal of physiology. Renal physiology 2000;279(6):F1033-44.
2000: Sampaio-Maia B; Soares-da-Silva P
Ca2+/calmodulin mediated pathways regulate the uptake of L-DOPA in mouse neuroblastoma neuro 2A cells.
Life sciences 2000;67(26):3209-20.
2000: Ambrósio A F; Silva A P; Araújo I; Malva J O; Soares-da-Silva P; Carvalho A P; Carvalho C M
Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024.
European journal of pharmacology 2000;406(2):191-201.
2000: Lucas-Teixeira V; Vieira-Coelho M A; Serrão M P; Soares-da-Silva P
Food deprivation increases alpha(2)-adrenoceptor-mediated modulation of jejunal epithelial transport in young and adult rats.
The Journal of nutrition 2000;130(10):2461-6.
2000: Soares-Da-Silva P; Serrão M P
Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells.
American journal of physiology. Renal physiology 2000;279(4):F736-46.
2000: Ferreira A; Bettencourt P; Pestana M; Oliveira N; Serrão P; Maciel M J; Cerqueira-Gomes M; Soares-da-Silva P
Renal synthesis of dopamine in asymptomatic post-infarction left ventricular systolic dysfunction.
Clinical science (London, England : 1979) 2000;99(3):195-200.
2000: Lucas-Teixeira V A; Vieira-Coelho M A; Serrão P; Pestana M; Soares-da-Silva P
Salt intake and sensitivity of intestinal and renal Na+-K+ atpase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2000;22(5):455-69.
2000: Parada A; Soares-da-Silva P
The dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization.
Neuropharmacology 2000;39(9):1645-52.
2000: Lucas-Teixeira V; Serrão M P; Soares-Da-Silva P
Response of jejunal Na+, K+-ATPase to 5-hydroxytryptamine in young and adult rats: effect of fasting and refeeding.
Acta physiologica Scandinavica 2000;169(2):167-72.
2000: Soares-Da-Silva P; Serrão M P
Outward transfer of dopamine precursor L-3,4-dihydroxyphenylalanine (L-dopa) by native and human P-glycoprotein in LLC-PK(1) and LLC-GA5 col300 renal cells.
The Journal of pharmacology and experimental therapeutics 2000;293(2):697-704.
2000: Soares-da-Silva P; Pestana M; Ferreira A; Damasceno A; Polónia J; Cerqueira-Gomes M
Renal dopaminergic mechanisms in renal parenchymal diseases, hypertension, and heart failure.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2000;22(3):251-68.
2000: Soares-da-Silva P; Parada A; Serrão P
The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase.
Brain research 2000;863(1-2):293-7.
2000: Lucas-Teixeira V; Vieira-Coelho M A; Soares-Da-Silva P
Food intake abolishes the response of rat jejunal Na(+),K(+)-ATPase to dopamine.
The Journal of nutrition 2000;130(4):877-81.
2000: Vieira-Coelho M A; Soares-da-Silva P
Ontogenic aspects of D1 receptor coupling to G proteins and regulation of rat jejunal Na+, K+ ATPase activity and electrolyte transport.
British journal of pharmacology 2000;129(3):573-81.
2000: Lucas-Teixeira V; Serrão M P; Soares-Da-Silva P
Effect of salt intake on jejunal dopamine, Na+,K+-ATPase activity and electrolyte transport.
Acta physiologica Scandinavica 2000;168(1):225-31.
2000: Tiago Guimarães J; Soares-da-Silva P
Unusual pattern of beta-phenylethylamine deamination in the rat heart.
Neurobiology (Budapest, Hungary) 2000;8(1):109-18.
1999: Damasceno A; Santos A; Serrão P; Caupers P; Soares-da-Silva P; Polónia J
Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects.
Journal of hypertension 1999;17(12 Pt 2):1995-2001.
1999: Gomes P; Soares-da-Silva P
Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells.
Neuropharmacology 1999;38(9):1371-80.
1999: Ambrósio A F; Silva A P; Malva J O; Soares-da-Silva P; Carvalho A P; Carvalho C M
Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists.
Neuropharmacology 1999;38(9):1349-59.
1999: Damasceno A; Santos A; Pestana M; Serrão P; Caupers P; Soares-da-Silva P; Polónia J
Acute hypotensive, natriuretic, and hormonal effects of nifedipine in salt-sensitive and salt-resistant black normotensive and hypertensive subjects.
Journal of cardiovascular pharmacology 1999;34(3):346-53.
1999: Benes J; Parada A; Figueiredo A A; Alves P C; Freitas A P; Learmonth D A; Cunha R A; Garrett J; Soares-da-Silva P
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.
Journal of medicinal chemistry 1999;42(14):2582-7.
1999: Sampaio-Maia B; Gomes R; Soares-da-Silva P
P-glycoprotein phosphorylation/dephosphorylation and cellular accumulation of L-DOPA in LLC-GA5 Col300 cells.
Journal of autonomic pharmacology 1999;19(3):173-9.
1999: Gomes P; Soares-da-Silva P
L-DOPA transport properties in an immortalised cell line of rat capillary cerebral endothelial cells, RBE 4.
Brain research 1999;829(1-2):143-50.
1999: Vieira-Coelho M A; Soares-da-Silva P
Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase.
Brain research 1999;821(1):69-78.
1999: Vieira-Coelho M A; Teixeira V L; Guimarães J T; Serrão M P; Soares-da-Silva P
Caco-2 cells in culture synthesize and degrade dopamine and 5-hydroxytryptamine: a comparison with rat jejunal epithelial cells.
Life sciences 1999;64(1):69-81.
1998: Vieira-Coelho M A; Teixeira V A; Finkel Y; Soares-Da-Silva P; Bertorello A M
Dopamine-dependent inhibition of jejunal Na+-K+-ATPase during high-salt diet in young but not in adult rats.
The American journal of physiology 1998;275(6 Pt 1):G1317-23.
1998: Guimarães J T; Vindis C; Soares-da-Silva P; Parini A
Molecular and kinetic characterization of monoamine oxidases in the rat heart.
Biochemical Society transactions 1998;26(4):S392.
1998: Pestana M; Jardim H; Afonso C; Serrão P; Santos N; Guerra L; Soares-da-Silva P
Renal dopaminergic system in nephrotic syndrome and after remission.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(10):2559-62.
1998: Borges N; Vieira-Coelho M A; Parada A; Soares-da-Silva P
Rat liver catechol-O-methyltransferase kinetics and assay methodology.
Journal of enzyme inhibition 1998;13(6):473-83.
1998: Vieira-Coelho M A; Soares-da-Silva P
Alpha2-adrenoceptors mediate the effect of dopamine on adult rat jejunal electrolyte transport.
European journal of pharmacology 1998;356(1):59-65.
1998: Vieira-Coelho M A; Soares-Da-Silva P
Uptake and intracellular fate of L-DOPA in a human intestinal epithelial cell line: Caco-2.
The American journal of physiology 1998;275(1 Pt 1):C104-12.
1998: Gomes P; Serrão M P; Vieira-Coelho M A; Soares-da-Silva P
L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan share the same transporter in Opossum kidney cells.
The international journal of biochemistry & cell biology 1998;30(2):243-50.
1998: Soares-Da-Silva P; Serrão M P; Vieira-Coelho M A
Apical and basolateral uptake and intracellular fate of dopamine precursor L-dopa in LLC-PK1 cells.
The American journal of physiology 1998;274(2 Pt 2):F243-51.
1998: Soares-da-Silva P; Serrão M P; Vieira-Coelho M A; Pestana M
Evidence for the involvement of P-glycoprotein on the extrusion of taken up L-DOPA in cyclosporine A treated LLC-PK1 cells.
British journal of pharmacology 1998;123(1):13-22.
1998: Pestana M; Jardim H; Serrão P; Soares-da-Silva P; Guerra L
Reduced urinary excretion of dopamine and metabolites in chronic renal parenchymal disease.
Kidney & blood pressure research 1998;21(1):59-65.
1998: Guimarães J T; Soares-da-Silva P
The activity of MAO A and B in rat renal cells and tubules.
Life sciences 1998;62(8):727-37.
1997: Pestana M; Faria M S; Oliveira J G; Baldaia J; Santos A; Guerra L E; Soares-da-Silva P
Assessment of renal dopaminergic system activity during the recovery of renal function in human kidney transplant recipients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(12):2667-72.
1997: Guimarães J T; Soares-Da-Silva P
Unusual pattern of beta-phenylethylamine deamination in the rat heart.
Biochemical Society transactions 1997;25(4):S622.
1997: Soares-da-Silva P; Vieira-Coelho M A; Serrão M P
Uptake of L-3,4-dihydroxyphenylalanine and dopamine formation in cultured renal epithelial cells.
Biochemical pharmacology 1997;54(9):1037-46.
1997: Gomes P; Serrão M P; Vieira-Coelho M A; Soares-da-Silva P
Competitive and non-competitive inhibition of L-3, 4-dihydroxyphenylalanine uptake in Opossum kidney cells.
European journal of pharmacology 1997;332(2):219-25.
1997: Borges N; Vieira-Coelho M A; Parada A; Soares-da-Silva P
Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain catechol-O-methyltransferase.
The Journal of pharmacology and experimental therapeutics 1997;282(2):812-7.
1997: Vieira-Coelho M A; Soares-da-Silva P
Apical and basal uptake of L-dopa and L-5-HTP and their corresponding amines, dopamine and 5-HT, in OK cells.
The American journal of physiology 1997;272(5 Pt 2):F632-9.
1997: Guimarães J T; Vieira-Coelho M A; Serrão M P; Soares-da-Silva P
Opossum kidney (OK) cells in culture synthesize and degrade the natriuretic hormone dopamine: a comparison with rat renal tubular cells.
The international journal of biochemistry & cell biology 1997;29(4):681-8.
1997: Gomes P; Serräo M P; Viera-Coelho M A; Soares-da-Silva P
Opossum kidney cells take up L-DOPA through an organic cation potential-dependent and proton-independent transporter.
Cell biology international 1997;21(4):249-55.
1997: Vieira-Coelho M A; Gomes P; Serrão M P; Soares-da-Silva P
Renal and intestinal autocrine monoaminergic systems: dopamine versus 5-hydroxytryptamine.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1997;19(1-2):43-58.
1996: Vieira-Coelho M A; Pestana M; Soares-da-Silva P
High sodium intake increases the urinary excretion of L-3,4-dihydroxyphenylalanine but fails to alter the urinary excretion of dopamine and amine metabolites in Wistar rats.
General pharmacology 1996;27(8):1421-7.
1996: Soares-da-Silva P; Serrão M P; Vieira-Coelho M A
A comparative study on the synthesis of the natriuretic hormone dopamine in OK and LLC-PK1 cells.
Cell biology international 1996;20(8):539-44.
1996: Pinto-do-O P C; Soares-da-Silva P
Studies on the pharmacology of the inward transport of L-DOPA in rat renal tubules.
British journal of pharmacology 1996;118(3):741-7.
1996: Soares-da-Silva P; Pinto-do-O P C; Bertorello A M
Antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in Na+, K(+)-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors.
British journal of pharmacology 1996;117(6):1199-203.
1996: Soares-da-Silva P; Vieira-Coelho M A; Pestana M
Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake.
British journal of pharmacology 1996;117(6):1193-8.
1996: Soares-da-Silva P; Pinto-do-O P C
Antagonistic actions of renal dopamine and 5-hydroxytryptamine: effects of amine precursors on the cell inward transfer and decarboxylation.
British journal of pharmacology 1996;117(6):1187-92.
1996: Vieira-Coelho M A; Soares-da-Silva P
Ontogenic aspects of liver and kidney catechol-O-methyltransferase sensitivity to tolcapone.
British journal of pharmacology 1996;117(3):516-520.
1995: Pestana M; Vieira-Coelho M A; Pinto-do-O P C; Fernandes M H; Soares-da-Silva P
Assessment of renal dopaminergic system activity during cyclosporine A administration in the rat.
British journal of pharmacology 1995;115(8):1349-58.
1995: Soares-da-Silva P; Vieira-Coelho M A; Pinto-do-O P C; Pestana M; Bertorello A M
Studies on the nature of the antagonistic actions of dopamine and 5-hydroxytryptamine in renal tissues.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18 Suppl 1():S47-51.
1995: Soares-da-Silva P; Pestana M; Vieira-Coelho M A; Fernandes M H; Albino-Teixeira A
Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model.
British journal of pharmacology 1995;114(7):1403-13.
1995: Soares-da-Silva P; Vieira-Coelho M A; Pestana M; Fernandes M H; Guimarães J T
Ontogeny of the cell outward dopamine transporter in canine renal tissues.
Fundamental & clinical pharmacology 1995;9(3):255-62.
1994: Pestana M; Soares-da-Silva P
Effect of type A and B monoamine oxidase selective inhibition by Ro 41-1049 and Ro 19-6327 on dopamine outflow in rat kidney slices.
British journal of pharmacology 1994;113(4):1269-74.
1994: Albino-Teixeira A; Soares-da-Silva P
Isosorbide 5-mononitrate reverses high blood pressure in NG-nitro-L-arginine methyl ester treated rats.
General pharmacology 1994;25(7):1329-36.
1994: Finkel Y; Eklöf A C; Granquist L; Soares-da-Silva P; Bertorello A M
Endogenous dopamine modulates jejunal sodium absorption during high-salt diet in young but not in adult rats.
Gastroenterology 1994;107(3):675-9.
1994: Pestana M; Soares-Da-Silva P
Outflow of dopamine and noradrenaline originating from L-dopa and L-threo-DOPS in rat renal tissues.
General pharmacology 1994;25(5):879-85.
1994: Villanueva M M; Soares-da-Silva P; Osswald W
Effect of sympathetic denervation on the relaxing responses of rabbit arterial smooth muscle.
Journal of autonomic pharmacology 1994;14(4):275-81.
1994: Soares-da-Silva P; Fernandes M H; Pinto-do-O P C
Cell inward transport of L-DOPA and 3-O-methyl-L-DOPA in rat renal tubules.
British journal of pharmacology 1994;112(2):611-5.
1994: Pestana M; Soares-da-Silva P
The renal handling of dopamine originating from L-dopa and gamma-glutamyl-L-dopa.
British journal of pharmacology 1994;112(2):417-22.
1994: Vieira-Coelho M A; Fernandes M H; Soares-da-Silva P
In vivo effects of the monoamine oxidase inhibitors Ro 41-1049 and Ro 19-6327 on the production and fate of renal dopamine.
Journal of neural transmission. Supplementum 1994;41():365-70.
1994: Fernandes M H; Soares-da-Silva P
Role of monoamine oxidase and catechol-O-methyltransferase in the metabolism of renal dopamine.
Journal of neural transmission. Supplementum 1994;41():101-5.
1993: Matias A; Soares-da-Silva P; Azevedo I
Neurotoxicity and induction of fibroblast proliferation by acetaldehyde in the rabbit liver.
Journal of autonomic pharmacology 1993;13(4):275-80.
1993: Soares-da-Silva P; Fernandes M H; Pestana M
A comparative study on the synthesis of dopamine in the human, dog and rat kidney.
Acta physiologica Scandinavica 1993;148(3):347-51.
1993: Soares-da-Silva P
Kinetic study of the tubular dopamine outward transporter in the rat and dog kidney.
British journal of pharmacology 1993;109(2):577-80.
1993: Soares-da-Silva P
Renal tubular dopamine outward transfer during Na(+)-H+ exchange activation by alpha 1- and alpha 2-adrenoceptor agonists.
British journal of pharmacology 1993;109(2):569-76.
1993: Soares-da-Silva P
Enhanced protein kinase C mediated inhibition of renal dopamine synthesis during high sodium intake.
Biochemical pharmacology 1993;45(9):1791-800.
1993: Soares-da-Silva P; Pestana M; Fernandes M H
Involvement of tubular sodium in the formation of dopamine in the human renal cortex.
Journal of the American Society of Nephrology : JASN 1993;3(9):1591-9.
1993: Soares-da-Silva P
Preferential decarboxylation of L-threo-3,4-dihydroxyphenylserine in rat renal tissues.
General pharmacology 1993;24(1):75-81.
1993: Soares-da-Silva P; Fernandes M H; Pestana M
Studies on the role of sodium on the synthesis of dopamine in the rat kidney.
The Journal of pharmacology and experimental therapeutics 1993;264(1):406-14.
1993: Vieira-Coelho M A; Soares-da-Silva P
Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract.
Fundamental & clinical pharmacology 1993;7(5):235-43.
1992: Soares-da-Silva P
Actin cytoskeleton, tubular sodium and the renal synthesis of dopamine.
Biochemical pharmacology 1992;44(9):1883-6.
1992: Fernandes M H; Soares-da-Silva P
Type A and B monoamine oxidase activities in the human and rat kidney.
Acta physiologica Scandinavica 1992;145(4):363-7.
1992: Soares-da-Silva P; Fernandes M H
Sodium-dependence and ouabain-sensitivity of the synthesis of dopamine in renal tissues of the rat.
British journal of pharmacology 1992;105(4):811-6.
1992: Soares-da-Silva P; Fernandes M H
Effect of alpha-human atrial natriuretic peptide on the synthesis of dopamine in the rat kidney.
British journal of pharmacology 1992;105(4):869-74.
1992: Soares-da-Silva P; Fernandes M H; Albino-Teixeira A; Azevedo I; Pestana M
Brief transient ischemia induces long-term depletion of norepinephrine without affecting the aromatic amino acid decarboxylase and monoamine oxidase activities in the rat kidney.
The Journal of pharmacology and experimental therapeutics 1992;260(2):902-8.
1992: Garrett M C; Soares-da-Silva P
Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington's disease: evidence for an overactive dopaminergic brain transmission.
Journal of neurochemistry 1992;58(1):101-6.
1991: Soares-Da-Silva P; Fernandes M H
A study on the renal synthesis of dopamine in aged rats.
Acta physiologica Scandinavica 1991;143(3):287-93.
1991: Soares-da-Silva P; Fernandes M H
Inhibitory effects of guanosine 3':5'-cyclic monophosphate on the synthesis of dopamine in the rat kidney.
British journal of pharmacology 1991;103(4):1923-7.
1991: Villanueva M M; Nunes J P; Soares-da-Silva P
Relaxant effects of alpha-human atrial natriuretic peptide on venous smooth muscle.
Journal of autonomic pharmacology 1991;11(3):139-45.
1991: Fernandes M H; Pestana M; Soares-da-Silva P
Deamination of newly-formed dopamine in rat renal tissues.
British journal of pharmacology 1991;102(3):778-82.
1990: Soares-da-Silva P; Garrett M C
Overflow of endogenous dopamine and 3,4-dihydroxyphenylacetic acid from tissues of the rat brain, elicited by electrical stimulation, depolarization by potassium and activation of carrier-mediated release.
Neuropharmacology 1990;29(12):1151-9.
1990: Fernandes M H; Soares-da-Silva P
Effects of MAO-A and MAO-B selective inhibitors Ro 41-1049 and Ro 19-6327 on the deamination of newly formed dopamine in the rat kidney.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1309-13.
1990: Soares-da-Silva P; Fernandes M H
Inhibition by the putative potassium channel opener pinacidil of the electrically-evoked release of endogenous dopamine and noradrenaline in the rat vas deferens.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(4):415-21.
1990: Garrett M C; Soares-da-Silva P
Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat.
Neuropharmacology 1990;29(10):875-9.
1990: Soares-da-Silva P; Garrett M C
A kinetic study of the rate of formation of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain of the rat: implications for the origin of DOPAC.
Neuropharmacology 1990;29(10):869-74.
1990: Soares-da-Silva P; Fernandes M H
Synthesis and metabolism of dopamine in the kidney. Effects of sodium chloride, monoamine oxidase inhibitors and alpha-human atrial natriuretic peptide.
American journal of hypertension 1990;3(6 Pt 2):7S-10S.
1990: Albino-Teixeira A; Matias A; Soares-da-Silva P; Sarmento A; Azevedo I
Effects of sympathetic denervation on liver fibroblasts: prevention by adenosine.
Journal of autonomic pharmacology 1990;10(3):181-9.
1990: Caramona M M; Soares-da-Silva P
Evidence for an extraneuronal location of monoamine oxidase in renal tissues.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(5):411-3.
1990: Fernandes M H; Soares-da-Silva P
Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney.
Journal of neural transmission. Supplementum 1990;32():155-9.
1988: Soares-da-Silva P
Evidence for dopaminergic co-transmission in dog mesenteric arterial vessels.
British journal of pharmacology 1988;95(1):218-24.
1988: Soares-da-Silva P
Further evidence for a noradrenaline-independent storage of dopamine in the dog kidney.
Journal of autonomic pharmacology 1988;8(2):127-33.
1987: Sarmento A; Soares-da-Silva P; Teixeira A A; Azevedo I
Effects of denervation induced by 6-hydroxydopamine on cell nucleus activity of arterial and cardiac cells of the dog.
Journal of autonomic pharmacology 1987;7(2):119-26.
1985: Esplugues J V; Caramona M M; Moura D; Soares-da-Silva P
Effects of chemical sympathectomy on dopamine and noradrenaline content of the dog gastrointestinal tract.
Journal of autonomic pharmacology 1985;5(3):189-95.

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