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Godfried Boers

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Peter Schadewaldt; Hans-Werner Hammen; Loganathan Kamalanathan; Udo Wendel; Martin Schwarz; Annet M Bosch; Nele Guion; Mirian Janssen; Godfried H J Boers
Biochemical monitoring of pregnancy and breast feeding in five patients with classical galactosaemia--and review of the literature.
Hieronim Jakubowski; Godfried H J Boers; Kevin A Strauss
Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans.
Grazyna Chwatko; Godfried H J Boers; Kevin A Strauss; Diana M Shih; Hieronim Jakubowski
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.

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2009: Peter Schadewaldt; Hans-Werner Hammen; Loganathan Kamalanathan; Udo Wendel; Martin Schwarz; Annet M Bosch; Nele Guion; Mirian Janssen; Godfried H J Boers
Biochemical monitoring of pregnancy and breast feeding in five patients with classical galactosaemia--and review of the literature.
European journal of pediatrics 2009;168(6):721-9.
2008: Hieronim Jakubowski; Godfried H J Boers; Kevin A Strauss
Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4071-6.
2007: Grazyna Chwatko; Godfried H J Boers; Kevin A Strauss; Diana M Shih; Hieronim Jakubowski
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1707-13.
2007: Sandra G Heil; Niels P Riksen; Godfried H J Boers; Yvo Smulders; Henk J Blom
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients.
Molecular genetics and metabolism 2007;91(1):55-60.
2007: Petr Vyletal; Jitka Sokolová; David N Cooper; Jan P Kraus; Michael Krawczak; Guglielmina Pepe; Olga Rickards; Hans Georg Koch; Michael Linnebank; Leo A J Kluijtmans; Henk J Blom; Godfried H J Boers; Mette Gaustadnes; Flemming Skovby; Bridget Wilcken; David E L Wilcken; Generoso Andria; Gianfranco Sebastio; Eileen Naughten; Sufin Yap; Toshihiro Ohura; Ewa Pronicka; Aranka Laszlo; Viktor Kozich
Diversity of cystathionine beta-synthase haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible role for gene conversion.
Human mutation 2007;28(3):255-64.
2005: Lilian J Meijboom; Frederiek E Vos; Janneke Timmermans; Godfried H J Boers; Aeiko H Zwinderman; Barbara J M Mulder
Pregnancy and aortic root growth in the Marfan syndrome: a prospective study.
European heart journal 2005;26(9):914-20.
2005: Lilian J Meijboom; Janneke Timmermans; Johan P van Tintelen; Gijs J Nollen; Julie De Backer; Maarten P van den Berg; Godfried H J Boers; Barbara J M Mulder
Evaluation of left ventricular dimensions and function in Marfan's syndrome without significant valvular regurgitation.
The American journal of cardiology 2005;95(6):795-7.
2005: Sarah Hutchinson; Robin T Aplin; Heather Webb; Susan Kettle; Janneke Timmermans; Godfried H J Boers; Penny A Handford
Molecular effects of homocysteine on cbEGF domain structure: insights into the pathogenesis of homocystinuria.
Journal of molecular biology 2005;346(3):833-44.
2005: Niels P Riksen; Gerard A Rongen; Henk J Blom; Godfried H J Boers; Paul Smits
Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(10):1001-6.
2005: Niels P Riksen; Gerard A Rongen; Godfried H J Boers; Henk J Blom; Petra H H van den Broek; Paul Smits
Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):109-14.
2004: Anita C T M Peeters; Martina Kucharekova; J Timmermans; F W P J van den Berkmortel; Godfried H J Boers; I R O Nováková; David Egging; Martin den Heijer; Joost Schalkwijk
A clinical and cardiovascular survey of Ehlers-Danlos syndrome patients with complete deficiency of tenascin-X.
The Netherlands journal of medicine 2004;62(5):160-2.
2004: Frank F Willems; Godfried H J Boers; Henk J Blom; Wim R M Aengevaeren; Freek W A Verheugt
Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease.
British journal of pharmacology 2004;141(5):825-30.
2003: Jos W M van der Meer; R van de Kerkhof; Gerard K H The; Godfried H J Boers
[Hemopyrrollactamuria (HPU); from spots to pseudo-disease].
Nederlands tijdschrift voor geneeskunde 2003;147(36):1720-1.
2003: Niels P Riksen; Gerard A Rongen; Henk J Blom; Frans G M Russel; Godfried H J Boers; Paul Smits
Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.
Cardiovascular research 2003;59(2):271-6.
2003: Karin J A Lievers; Leo A J Kluijtmans; Sandra G Heil; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Cystathionine beta-synthase polymorphisms and hyperhomocysteinaemia: an association study.
European journal of human genetics : EJHG 2003;11(1):23-9.
2002: Ruby Evande; Henk Blom; Godfried H J Boers; Ruma Banerjee
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase.
Biochemistry 2002;41(39):11832-7.
2002: Karin J A Lievers; Leo A J Kluijtmans; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.
Atherosclerosis 2002;164(2):269-73.
2002: Karin J A Lievers; Lydia A Afman; Leo A J Kluijtmans; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients.
Clinical chemistry 2002;48(9):1383-9.
2002: Frank F Willems; Wim R M Aengevaeren; Godfried H J Boers; Henk J Blom; Freek W A Verheugt
Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease.
Journal of the American College of Cardiology 2002;40(4):766-72.
2001: Sufin Yap; Godfried H J Boers; Bridget Wilcken; David E L Wilcken; D P Brenton; P J Lee; J H Walter; PM Howard; Eileen Naughten
Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):2080-5.
2001: Karin J A Lievers; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Leo A J Kluijtmans; N M J van der Put; Frans J M Trijbels; Henk J Blom
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk.
Journal of molecular medicine (Berlin, Germany) 2001;79(9):522-8.
2001: Karin J A Lievers; Leo A J Kluijtmans; Sandra G Heil; Godfried H J Boers; Petra Verhoef; D van Oppenraay-Emmerzaal; Martin den Heijer; Frans J M Trijbels; Henk J Blom
A 31 bp VNTR in the cystathionine beta-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels.
European journal of human genetics : EJHG 2001;9(8):583-9.
2001: Godfried H J Boers
[From gene to disease; from homocysteine to hyperhomocysteinemia].
Nederlands tijdschrift voor geneeskunde 2001;145(20):956-8.
2000: Sandra G Heil; Karin J A Lievers; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans.
Molecular genetics and metabolism 2000;71(3):511-9.
2000: Sufin Yap; Eileen Naughten; Bridget Wilcken; David E L Wilcken; Godfried H J Boers
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
Seminars in thrombosis and hemostasis 2000;26(3):335-40.
1999: Leo A J Kluijtmans; Godfried H J Boers; Jan P Kraus; L P van den Heuvel; J R Cruysberg; Frans J M Trijbels; H J Blom
The molecular basis of cystathionine beta-synthase deficiency in Dutch patients with homocystinuria: effect of CBS genotype on biochemical and clinical phenotype and on response to treatment.
American journal of human genetics 1999;65(1):59-67.
1999: Jan P Kraus; Miroslav Janosík; Viktor Kozich; R Mandell; Vivian E Shih; Maria Pia Sperandeo; Gianfranco Sebastio; Raffaella de Franchis; Generoso Andria; Leo A J Kluijtmans; H Blom; Godfried H J Boers; Ross B Gordon; P Kamoun; M Y Tsai; warren kruger; Hans Georg Koch; T Ohura; Mette Gaustadnes
Cystathionine beta-synthase mutations in homocystinuria.
Human mutation 1999;13(5):362-75.
1998: Tineke J Smilde; F W P J van den Berkmortel; Godfried H J Boers; Hub Wollersheim; Theo M de Boo; Herman van Langen; Anton F H Stalenhoef
Carotid and femoral artery wall thickness and stiffness in patients at risk for cardiovascular disease, with special emphasis on hyperhomocysteinemia.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(12):1958-63.
1998: Leo A J Kluijtmans; Godfried H J Boers; B Verbruggen; Frans J M Trijbels; I R Novakova; Henk J Blom
Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis.
Blood 1998;91(6):2015-8.
1997: Leo A J Kluijtmans; J J Kastelein; Jan Lindemans; Godfried H J Boers; Sandra G Heil; A V Bruschke; J W Jukema; Lambert P van den Heuvel; Frans J M Trijbels; G J Boerma; F W Verheugt; F Willems; Henk J Blom
Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.
Circulation 1997;96(8):2573-7.
1997: Leo A J Kluijtmans; Godfried H J Boers; Frans J M Trijbels; H M van Lith-Zanders; Lambert P van den Heuvel; Henk J Blom
A common 844INS68 insertion variant in the cystathionine beta-synthase gene.
Biochemical and molecular medicine 1997;62(1):23-5.
1996: D G Franken; Henk J Blom; Godfried H J Boers; A Tangerman; C M Thomas; Frans J M Trijbels
Thiamine (vitamin B1) supplementation does not reduce fasting blood homocysteine concentration in most homozygotes for homocystinuria.
Biochimica et biophysica acta 1996;1317(2):101-4.
1996: M van den Berg; Godfried H J Boers
Homocystinuria: what about mild hyperhomocysteinaemia?
Postgraduate medical journal 1996;72(851):513-8.
1996: D G Franken; Godfried H J Boers; Henk J Blom; J R Cruysberg; Frans J M Trijbels; B C Hamel
Prevalence of familial mild hyperhomocysteinemia.
Atherosclerosis 1996;125(1):71-80.
1996: Leo A J Kluijtmans; Godfried H J Boers; E M Stevens; W O Renier; Jan P Kraus; Frans J M Trijbels; L P van den Heuvel; Henk J Blom
Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.
The Journal of clinical investigation 1996;98(2):285-9.
1996: Leo A J Kluijtmans; L P van den Heuvel; Godfried H J Boers; Phyllis Frosst; E M Stevens; BA van Oost; Martin den Heijer; Frans J M Trijbels; Rima Rozen; Henk J Blom
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
American journal of human genetics 1996;58(1):35-41.
1995: Leo A J Kluijtmans; Henk J Blom; Godfried H J Boers; BA van Oost; Frans J M Trijbels; L P van den Heuvel
Two novel missense mutations in the cystathionine beta-synthase gene in homocystinuric patients.
Human genetics 1995;96(2):249-50.
1995: M van den Berg; M S van der Knaap; Godfried H J Boers; C D Stehouwer; Jan A Rauwerda; J Valk
Hyperhomocysteinaemia; with reference to its neuroradiological aspects.
Neuroradiology 1995;37(5):403-11.
1995: Viktor Kozich; Eva Kraus; Raffaella de Franchis; B Fowler; Godfried H J Boers; I Graham; Jan P Kraus
Hyperhomocysteinemia in premature arterial disease: examination of cystathionine beta-synthase alleles at the molecular level.
Human molecular genetics 1995;4(4):623-9.
1995: M T te Poele-Pothoff; M van den Berg; D G Franken; Godfried H J Boers; C Jakobs; I F de Kroon; Tom K A B Eskes; J M F Trijbels; Henk J Blom
Three different methods for the determination of total homocysteine in plasma.
Annals of clinical biochemistry 1995;32 ( Pt 2)():218-20.
1995: M Van den Berg; Godfried H J Boers; D G Franken; Henk J Blom; G J Van Kamp; C Jakobs; Jan A Rauwerda; Cornelis Kluft; C D Stehouwert
Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease.
European journal of clinical investigation 1995;25(3):176-81.
1995: Henk J Blom; H A Kleinveld; Godfried H J Boers; Pierre N M Demacker; H L Hak-Lemmers; M T Te Poele-Pothoff; J M F Trijbels
Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia.
European journal of clinical investigation 1995;25(3):149-54.
1995: A M Engbersen; D G Franken; Godfried H J Boers; E M Stevens; Frans J M Trijbels; Henk J Blom
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.
American journal of human genetics 1995;56(1):142-50.
1994: M van den Berg; D G Franken; Godfried H J Boers; Henk J Blom; C Jakobs; C D Stehouwer; Jan A Rauwerda
Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.
Journal of vascular surgery 1994;20(6):933-40.
1994: D G Franken; Godfried H J Boers; Henk J Blom; Frans J M Trijbels; P W Kloppenborg
Treatment of mild hyperhomocysteinemia in vascular disease patients.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(3):465-70.
1994: D G Franken; Godfried H J Boers; Henk J Blom; J M F Trijbels
Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocysteinaemia in vascular patients.
Journal of inherited metabolic disease 1994;17(1):159-62.
1993: D G Franken; A Vreugdenhil; Godfried H J Boers; A Verrips; Henk J Blom; I R Novakova
Familial cerebrovascular accidents due to concomitant hyperhomocysteinemia and protein C deficiency type 1.
Stroke; a journal of cerebral circulation 1993;24(10):1599-600.
1992: Henk J Blom; D P Engelen; Godfried H J Boers; A M Stadhouders; Rob C A Sengers; Ronney A De Abreu; M T TePoele-Pothoff; J M F Trijbels
Lipid peroxidation in homocysteinaemia.
Journal of inherited metabolic disease 1992;15(3):419-22.
1991: Henk J Blom; Godfried H J Boers; A Tangerman; William A Gahl; J M F Trijbels
Alternative methionine degradation via the transamination pathway: an option for therapy for homocystinuria due to cystathionine synthase deficiency.
Journal of inherited metabolic disease 1991;14(3):375-8.
1989: Henk J Blom; Godfried H J Boers; J M F Trijbels; J J van Roessel; Albert Tangerman
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Metabolism: clinical and experimental 1989;38(6):577-82.
1989: Henk J Blom; Godfried H J Boers; J P van den Elzen; William A Gahl; Albert Tangerman
Transamination of methionine in humans.
Clinical science (London, England : 1979) 1989;76(1):43-9.
1989: Godfried H J Boers
Carriership for homocystinuria in juvenile vascular disease.
Haemostasis 1989;19 Suppl 1():29-34.
1988: Henk J Blom; Godfried H J Boers; J P van den Elzen; J J van Roessel; J M Trijbels; Albert Tangerman
Differences between premenopausal women and young men in the transamination pathway of methionine catabolism, and the protection against vascular disease.
European journal of clinical investigation 1988;18(6):633-8.