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Hilkka Soininen

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Lies Clerx; Remko de Jong; Lutz Froelich; Harald Hampel; Dirk L Knol; Pablo Lapuerta; Lennart Minthon; Flavio Nobili; Daniel Rueckert; Philip scheltens; Hilkka Soininen; Magdalini Tsolaki; Laura A van de Pol; Ineke A van Rossum; Ronald van Schijndel; Frans Verhey; Pauline Aalten; Frederik Barkhof; Martina Bocchetta; Leah Burns; Lars-Olaf Wahlund; Robin Wolz; Pieter Jelle Visser
Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment.
Minna Rusanen; Hilkka Soininen; Jaakko Tuomilehto; Tiina Laatikainen; Tiia Ngandu; Miia Kivipelto
Chronic Obstructive Pulmonary Disease and Asthma and the Risk of Mild Cognitive Impairment and Dementia: A Population Based CAIDE Study.
Francesca Mangialasche; Patrizia Mecocci; J-S Muehlboeck; Andrew Simmons; Hilkka Soininen; Christian Spenger; Roberto Tarducci; M Tsolaki; Bruno Vellas; L-O Wahlund; E Westman; M Baglioni; Roberta Cecchetti; P Floridi; Gianni Gobbi; Miia Kivipelto; I Kłoszewska; Simon Lovestone
Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol.

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All Publications

2013: Lies Clerx; Remko de Jong; Lutz Froelich; Harald Hampel; Dirk L Knol; Pablo Lapuerta; Lennart Minthon; Flavio Nobili; Daniel Rueckert; Philip scheltens; Hilkka Soininen; Magdalini Tsolaki; Laura A van de Pol; Ineke A van Rossum; Ronald van Schijndel; Frans Verhey; Pauline Aalten; Frederik Barkhof; Martina Bocchetta; Leah Burns; Lars-Olaf Wahlund; Robin Wolz; Pieter Jelle Visser
Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment.
Neurobiology of aging 2013;34(8):2003-13.
2013: Minna Rusanen; Hilkka Soininen; Jaakko Tuomilehto; Tiina Laatikainen; Tiia Ngandu; Miia Kivipelto
Chronic Obstructive Pulmonary Disease and Asthma and the Risk of Mild Cognitive Impairment and Dementia: A Population Based CAIDE Study.
Current Alzheimer research 2013;10(5):549-55.
2013: Francesca Mangialasche; Patrizia Mecocci; J-S Muehlboeck; Andrew Simmons; Hilkka Soininen; Christian Spenger; Roberto Tarducci; M Tsolaki; Bruno Vellas; L-O Wahlund; E Westman; M Baglioni; Roberta Cecchetti; P Floridi; Gianni Gobbi; Miia Kivipelto; I Kłoszewska; Simon Lovestone
Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol.
Journal of internal medicine 2013;273(6):602-21.
2013: Carlos Aguilar; Iwona Kloszewska; Simon Lovestone; Patrizia Mecocci; J-Sebastian Muehlboeck; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Eric Westman; Lars-Olof Wahlund
Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment.
Psychiatry research 2013;212(2):89-98.
2013: I H G B Ramakers; Marcel Olde Rikkert; Philip scheltens; L M Shaw; Hilkka Soininen; Luiza Spiru; J Q Trojanowski; Marcel M Verbeek; F R J Verhey; Pieter Jelle Visser; Pauline Aalten; Kaj Blennow; Harald Hampel
Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment.
Psychological medicine 2013;43(5):911-20.
2013: Stephanie J B Vos; Lars-Olof Wahlund; Robin Wolz; Kaj Blennow; Giovanni B Frisoni; Lutz Froelich; Harald Hampel; Dirk L Knol; Lennart Minthon; Flavio Nobili; Philip scheltens; Hilkka Soininen; Magda Tsolaki; Wiesje van der Flier; Ineke A van Rossum; Frans Verhey; Pieter Jelle Visser
Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI.
Neurology 2013;80(12):1124-32.
2013: Anna-Maija Tolppanen; Miia Kivipelto; Piia Lavikainen; Hilkka Soininen; Alina Solomon; Sirpa Hartikainen
Incidence of stroke in people with Alzheimer disease: a national register-based approach.
Neurology 2013;80(4):353-8.
2013: Mikko Hiltunen; Annakaisa Haapasalo; Hilkka Soininen
[New risk genes for Alzheimer's disease--biomarkers predicting the disease?].
Duodecim; lääketieteellinen aikakauskirja 2013;129(6):583-8.
2013: Lyzel S Elias-Sonnenschein; Anette Hall; Seppo Helisalmi; Sanna-Kaisa Herukka; Anne M Koivisto; Marjo Laitinen; Terho Lehtimäki; Kari M Mattila; Teemu Natunen; Teemu Paajanen; Anne M Remes; Hilkka Soininen; Frans R J Verhey; Pieter Jelle Visser; Mikko Hiltunen
Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.
PloS one 2013;8(4):e59676.
2013: Anna-Maija Tolppanen; Piia Lavikainen; Hilkka Soininen; Sirpa Hartikainen
Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort.
PloS one 2013;8(3):e59124.
2013: Mari Takalo; Mikko Hiltunen; Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo
Protein aggregation and degradation mechanisms in neurodegenerative diseases.
American journal of neurodegenerative disease 2013;2(1):1-14.
2013: Miguel Ángel Muñoz-Ruiz; Ritva Vanninen; Anette Hall; Päivi Hartikainen; Sanna-Kaisa Herukka; Valtteri Julkunen; Juha Koikkalainen; Yawu Liu; Jyrki Lötjönen; Jussi Mattila; Hilkka Soininen
Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment.
Journal of Alzheimer's disease : JAD 2013;35(4):727-39.
2013: Yawu Liu; Jyrki Lötjönen; Jussi Mattila; Teemu Paajanen; Miguel Ángel Muñoz Ruiz; Hilkka Soininen; Mark van Gils; Gunhild Waldemar; Sanna-Kaisa Herukka; Juha Koikkalainen
Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool.
PloS one 2013;8(2):e55246.
2013: Angelique P A Vermeiren; Pieter-Jelle Visser; Lars-Olof Wahlund; Gordon K Wilcock; Maurice P Zeegers; Hans Bosma; Lyzel S Elias-Sonnenschein; Michael Ewers; Giovanni B Frisoni; Lutz Froelich; Caroline Graff; Harald Hampel; Roy W Jones; Patrick G Kehoe; HERMINE LENOIR; Lennart Minthon; Flavio M Nobili; Marcel Olde Rikkert; Anne-Sophie Rigaud; Philip scheltens; Hilkka Soininen; Luiza Spiru; Magda Tsolaki; Bruno Vellas; Frans R J Verhey
The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study.
Journal of Alzheimer's disease : JAD 2013;35(2):241-6.
2013: Latha Velayudhan; Bruno Vellas; Eric Westman; Angela Hodges; Iwona Kłoszewska; Simon Lovestone; Patrizia Mecocci; J-Sebastian Muehlboeck; John Powell; Petroula Proitsi; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki
Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33(3):755-66.
2013: Katie Lunnon; Michelle K Lupton; Patrizia Mecocci; Petroula Proitsi; Martina Sattlecker; Andrew Simmons; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Giovanni Coppola; Richard Dobson; Simon J Furney; Daniel Geschwind; Angela Hodges; Caroline Johnston; Iwona Kłoszewska; Anbarasu Lourdusamy; Simon Lovestone
A blood gene expression marker of early Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33(3):737-53.
2013: Anne Maria Koivisto; Mitja Kurki; Ville Leinonen; Jaakko Rinne; Jaana Rummukainen; Sakari Savolainen; Hilkka Soininen; Anna Sutela; Irina Alafuzoff; Juha E Jääskeläinen
Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus.
Neurosurgery 2013;72(1):1-8;discussion 8.
2013: Miika Vuorinen; Gabriela Spulber; Valtteri Julkunen; Ingemar Kåreholt; Miia Kivipelto; Eini Niskanen; Teemu Paajanen; Hilkka Soininen; Alina Solomon
Changes in vascular factors 28 years from midlife and late-life cortical thickness.
Neurobiology of aging 2013;34(1):100-9.
2013: Anna Kämäläinen; Tarja Kauppinen; Miia Kivipelto; Teemu Natunen; Maria Pikkarainen; Juha-Pekka Pursiheimo; Hilkka Soininen; Jayashree Viswanathan; Irina Alafuzoff; Annakaisa Haapasalo; Seppo Helisalmi; Sanna-Kaisa Herukka; Mikko Hiltunen
GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients.
Journal of Alzheimer's disease : JAD 2013;33(1):23-7.
2013: Alina Solomon; Miia Kivipelto; Hilkka Soininen
Prevention of Alzheimer's disease: moving backward through the lifespan.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S465-9.
2012: Okko T Pyykkö; Jaakko Rinne; Jaana Rummukainen; Sakari Savolainen; Hilkka Soininen; Juha E Jääskeläinen; Anne M Koivisto; Ville Leinonen; Juhani A A Mölsä; Ossi Nerg; Irina Alafuzoff; Seppo Helisalmi; Mikko Hiltunen
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus.
Journal of neurology, neurosurgery, and psychiatry 2012;83(11):1119-24.
2012: Vladimir Coric; Randy Dockens; Howard H Feldman; Chahin Pachai; Gary Pilcher; Erik Portelius; Ralph W Richter; Linda Rollin; Stephen Salloway; Thomas Shiovitz; Holly Soares; Hilkka Soininen; Stephen Thein; Christopher H van Dyck; Charles Albright; Niels Andreasen; Ulf Andreasson; Kaj Blennow; Mark Brody; Susan Colby; Robert M Berman
Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease.
Archives of neurology 2012;69(11):1430-40.
2012: Timo Sarajärvi; Hilkka Soininen; Annakaisa Haapasalo; Jukka Jolkkonen; Anu Lipsanen; Petra Mäkinen; Sirpa Peräniemi; Mikko Hiltunen
Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats.
Journal of cellular and molecular medicine 2012;16(11):2754-67.
2012: Ineke A van Rossum; Frans Verhey; Stephanie J B Vos; Lars-Olof Wahlund; Robin Wolz; Frederik Barkhof; Kaj Blennow; Leah Burns; Harald Hampel; Dirk L Knol; Gilbert L'italien; Lennart Minthon; Daniel Rueckert; Philip scheltens; Hilkka Soininen; Charlotte E Teunissen; Magda Tsolaki; Wiesje M van der Flier; Pieter Jelle Visser
Injury markers predict time to dementia in subjects with MCI and amyloid pathology.
Neurology 2012;79(17):1809-16.
2012: Stephanie Vos; Lars-Olof Wahlund; Robin Wolz; Pauline Aalten; Frederik Barkhof; Kaj Blennow; Leah Burns; Harald Hampel; Ron Handels; Dirk Knol; Gilbert L'Italien; Lennart Minthon; Daniel Rueckert; Philip scheltens; Hilkka Soininen; Charlotte E Teunissen; Magda Tsolaki; Wiesje van der Flier; Ineke van Rossum; Frans Verhey; Pieter Jelle Visser
Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI.
Neurobiology of aging 2012;33(10):2272-81.
2012: Francesca Mangialasche; Patrizia Mecocci; Martina Pigliautile; Andrew Simmons; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Weili Xu; Mauro Baglioni; Roberta Cecchetti; Egidia Costanzi; Sara Ercolani; Miia Kivipelto; Iwona Kloszewska; Simon Lovestone
Tocopherols and tocotrienols plasma levels are associated with cognitive impairment.
Neurobiology of aging 2012;33(10):2282-90.
2012: Yawu Liu; Simon Lovestone; Patrizia Mecocci; Sebastian Muehlboeck; Teemu Paajanen; Andrew Simmons; Tomasz Sobow; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Eric Westman; Andrew Aitken; Valtteri Julkunen
Education increases reserve against Alzheimer's disease--evidence from structural MRI analysis.
Neuroradiology 2012;54(9):929-38.
2012: Anbarasu Lourdusamy; Simon Lovestone; Katie Lunnon; Patrizia Mecocci; Sally K Nelson; Stephan Newhouse; John Powell; Petra Proitsi; Hilkka Soininen; Alex Stewart; Magda Tsolaki; Bruno Vellas; Stephen Williams; Richard Dobson; Angela Hodges; Iwona Kloszewska
Identification of cis-regulatory variation influencing protein abundance levels in human plasma.
Human molecular genetics 2012;21(16):3719-26.
2012: Petroula Proitsi; David C Rubinsztein; Hilkka Soininen; Stephen Todd; Magda Tsolaki; Bruno Velas; Julie Williams; Janet Johnson; Megan Pritchard; Carol Brayne; David Craig; Makrina Daniilidou; Frank Dudbridge; Michael Gill; Gillian Hamilton; Denise Harold; Paul Hollingworth; Iwona Kloszewska; Brian Lawlor; Kathryn Lord; Simon Lovestone; Michelle K Lupton; Belinda M Martin; Bernadette McGuinness; Patrizia Mecocci; Peter Passmore; John F Powell
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.
Neurobiology of aging 2012;33(8):1843.e9-17.
2012: Mikko Hiltunen; Susanna Kemppainen; Vinoth K M Khandelwal; Henna Koivisto; Marine Krzisch; Markku Laakso; Petra Mäkinen; Pasi Miettinen; Hilkka Soininen; Tea Tiilikainen; Maija Tusa; Saila Vepsäläinen; Nagendra Yaluri; Annakaisa Haapasalo; Heikki Tanila
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.
Journal of cellular and molecular medicine 2012;16(6):1206-22.
2012: Gabriela Spulber; Ritva Vanninen; Lars-Olof Wahlund; Merja Hallikainen; Valtteri Julkunen; Miia Kivipelto; Stuart Macdonald; Eini Niskanen; Daniel Ferreira Padilla; Hilkka Soininen
Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD.
Current Alzheimer research 2012;9(4):516-24.
2012: Stefan Lehnert; Martin Lenter; Patrick Oeckl; Boris Ferger; Bastian Hengerer; Sanna-Kaisa Herukka; Sarah Jesse; Wolfgang Rist; Hilkka Soininen; Petra Steinacker; Hayrettin Tumani; Markus Otto
iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia.
Experimental neurology 2012;234(2):499-505.
2012: Päivi Hartikainen; Maria Pikkarainen; Hilkka Soininen; Tuomo Hänninen; Irina Alafuzoff
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology 2012;32(1):60-8.
2012: Miguel Ángel Muñoz-Ruiz; Eini Niskanen; Daniel Rueckert; Päivi Hartikainen; Sanna-Kaisa Herukka; Valtteri Julkunen; Miia Kivipelto; Juha Koikkalainen; Yawu Liu; Jyrki Lötjönen; Ritva Vanninen; Robin Wolz; Hilkka Soininen
Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry.
PloS one 2012;7(12):e52531.
2012: Anja H Simonsen; Hilkka Soininen; Mark van Gils; Kristian S Frederiksen; Merja Hallikainen; Anne-Mette Hejl; Sanna-Kaisa Herukka; Jyrki Lötjönen; Jussi Mattila; Gunhild Waldemar
Application of the PredictAD software tool to predict progression in patients with mild cognitive impairment.
Dementia and geriatric cognitive disorders 2012;34(5-6):344-50.
2012: Sarah Jesse; Hans A Kretzschmar; Hasan Kulaksiz; Stefan Lehnert; Martin Lenter; Manuela Neumann; Boris Ferger; Bastian Hengerer; Sanna-Kaisa Herukka; Olaf Jahn; Lucilla Parnetti; Hilkka Soininen; Petra Steinacker; Saskia Tawfik; Hayrettin Tumani; Christine A F Von Arnim; Jens Wiltfang; Markus Otto
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.
PloS one 2012;7(11):e48783.
2012: Ines Greco; Iwona Kłoszewska; Julie Barnes; Nicola Day; Patrizia Mecocci; Jane Reed; Joanna Riddoch-Contreras; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Simon Lovestone
Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation.
Journal of translational medicine 2012;10():217.
2012: Steven John Kiddle; Iwona Kloszewska; Simon Lovestone; Katie Lunnon; Michelle Katharine Lupton; Patrizia Mecocci; Stephen Newhouse; Ian Pike; Joanna Riddoch-Contreras; Andrew Simmons; Hilkka Soininen; Madhav Thambisetty; Magda Tsolaki; Bruno Vellas; Malcolm Ward; Eric Westman; Richard Dobson; Abdul Hye; Caroline Johnston
Plasma based markers of [11C] PiB-PET brain amyloid burden.
PloS one 2012;7(9):e44260.
2012: Jussi Mattila; Daniel Rueckert; Hilkka Soininen; Gunhild Waldemar; Robin Wolz; Juha Koikkalainen; Jyrki Lötjönen
Optimizing the diagnosis of early Alzheimer's disease in mild cognitive impairment subjects.
Journal of Alzheimer's disease : JAD 2012;32(4):969-79.
2012: Anna-Maija Tolppanen; Hilkka Soininen; Alina Solomon; Miia Kivipelto
Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies.
Journal of Alzheimer's disease : JAD 2012;32(3):531-40.
2012: Ilona Hallikainen; Sanna-Kaisa Herukka; Asta Hiltunen; Pertti Karppi; Anne M Koivisto; Teemu Paajanen; Hilkka Soininen; Tarja Välimäki; Matti Vanhanen; Tuomo Hänninen
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer's Disease: Kuopio ALSOVA Study.
Dementia and geriatric cognitive disorders extra 2012;2():209-18.
2012: Karin Wallin; Ingemar Kåreholt; Hilkka Soininen; Alina Solomon; Jaakko Tuomilehto; Miia Kivipelto
Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study.
Journal of Alzheimer's disease : JAD 2012;31(3):669-76.
2012: Katie Lunnon; Patrizia Mecocci; Stephen Newhouse; Petroula Proitsi; Muzamil Saleem; Martina Sattlecker; Andrew Simmons; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Giovanni Coppola; Richard Dobson; Simon J Furney; Daniel Geschwind; Angela Hodges; Zina Ibrahim; Iwona Kłoszewska; Anbarasu Lourdusamy; Simon Lovestone
Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood.
Journal of Alzheimer's disease : JAD 2012;30(3):685-710.
2012: Päivi Hartikainen; Valtteri Julkunen; Miia Kivipelto; Eini Niskanen; Janne Räsänen; Anne M Remes; Merja Hallikainen; Ritva Vanninen; Hilkka Soininen
Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;30(4):857-74.
2012: Juha Koikkalainen; Jyrki Lötjönen; Jussi Mattila; Harri Pölönen; Hilkka Soininen; Mark van Gils
Improved classification of Alzheimer's disease data via removal of nuisance variability.
PloS one 2012;7(2):e31112.
2012: Ville Leinonen; Okko T Pyykkö; Jaakko Rinne; Jaana Rummukainen; Irina Alafuzoff; Juha E Jääskeläinen; Anne M Koivisto; Hilkka Soininen; Mikael von und zu Fraunberg; Sakari Savolainen
Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus.
Neuro-degenerative diseases 2012;10(1-4):166-9.
2012: Bruno Dubois; Michael F Murphy; Francesc Pujadas-Navinés; Michael Rainer; Henry J Riordan; Philippe Robert; Hilkka Soininen; Jacques Touchon; Bruno Vellas; Mohammed Zaim; Claire Kanony-Truc
Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;29(3):527-35.
2012: Lennart Thurfjell; Gunhild Waldemar; David J Brooks; Juha Koikkalainen; Jyrki Lötjönen; Roger Lundqvist; Hilkka Soininen; Rik Vandenberghe
Combination of biomarkers: PET [18F]flutemetamol imaging and structural MRI in dementia and mild cognitive impairment.
Neuro-degenerative diseases 2012;10(1-4):246-9.
2012: Hilkka Soininen; Lennart Thurfjell; Mark van Gils; Gunhild Waldemar; A Hviid Simonsen; Juha Koikkalainen; Jyrki Lötjönen; Jussi Mattila; Daniel Rueckert
Software tool for improved prediction of Alzheimer's disease.
Neuro-degenerative diseases 2012;10(1-4):149-52.
2012: Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo; Mikko Hiltunen; Kai Kaarniranta; Irina Alafuzoff
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease.
Progress in neurobiology 2012;96(1):87-95.
2012: Teemu Natunen; Timo Sarajärvi; Hilkka Soininen; Saila Vepsäläinen; Leila Antikainen; Annakaisa Haapasalo; Seppo Helisalmi; Sanna-Kaisa Herukka; Anne Maria Koivisto; Petra Mäkinen; Mikko Hiltunen
Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;28(3):553-9.
2012: Heidi I L Jacobs; Jelle Jolles; Lennart Minthon; Flavio Nobili; Panagiota Papapostolou; Philip scheltens; Hilkka Soininen; Frans E S Tan; Magda Tsolaki; Martin P J Van Boxtel; Laura A van de Pol; Giovanni B Frisoni; Lutz Froelich; Harald Hampel; Pieter Jelle Visser; Lars-Olof Wahlund; Frans R J Verhey
Association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent.
Neurobiology of aging 2012;33(1):201.e1-8.
2011: Maria Pikkarainen; Hilkka Soininen; Päivi Hartikainen; Irina Alafuzoff
Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry.
Cerebellum (London, England) 2011;10(4):720-31.
2011: Pauliina Korhonen; Sergiy Kyrylenko; E M Mandelkow; Johanna Ojala; Erik Peltomaa; Antero Salminen; M-L Soininen; Heikki Tanila; A Thornell; Thomas van Groen; Hilkka Soininen
Characterization of a novel transgenic rat carrying human tau with mutation P301L.
Neurobiology of aging 2011;32(12):2314-5.
2011: Simon J Furney; A Hodges; S Kim; Iwona Kloszewska; Mark Lathrop; Simon Lovestone; K Lunnon; Patrizia Mecocci; I Pedroso; J Powell; P Proitsi; A J Saykin; L Shen; Andrew Simmons; Hilkka Soininen; Christian Spenger; M Tsolaki; Bruno Vellas; Lars-Olof Wahlund; M W Weiner; Gerome Breen
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
Molecular psychiatry 2011;16(11):1130-8.
2011: Eric Westman; Iwona Kłoszewska; Simon Lovestone; Patrizia Mecocci; J-Sebastian Muehlboeck; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Michael W Weiner
AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America.
NeuroImage 2011;58(3):818-28.
2011: E Genin; D Hannequin; O Hanon; S Helisalmi; M Hiltunen; M I Kamboh; J C Lambert; F Licastro; M Mancuso; I Mateo; B Nacmias; Francesco Panza; F Pasquier; P Piccardi; A Pilotto; E Porcellini; E Scarpini; D Seripa; G Siciliano; K Sleegers; Hilkka Soininen; V Solfrizzi; Sandro Sorbi; G Spalletta; G Tognoni; F Valdivieso; Christine Van Broeckhoven; S Vepsäläinen; D Wallon; V Alvarez; P Amouyel; G Annoni; B Arosio; C Berr; K Bettens; P Bosco; P Bossù; N Brouwers; M J Bullido; O Combarros; E Coto; Jean-François Dartigues; P De Deyn; Maria Del Zompo; B Dubois; S Engelborghs; J Epelbaum; R Ferri; N Fiévet; P Forti; A Frank-Garcia; D Galimberti; D Campion
APOE and Alzheimer disease: a major gene with semi-dominant inheritance.
Molecular psychiatry 2011;16(9):903-7.
2011: Yawu Liu; Gabriela Spulber; Ritva Vanninen; Heidi Gröhn; Ilona Hallikainen; Merja Hallikainen; Miia Kivipelto; Mervi Könönen; Kimmo Kristian Lehtimäki; Hilkka Soininen
Diffusion tensor imaging and tract-based spatial statistics in Alzheimer's disease and mild cognitive impairment.
Neurobiology of aging 2011;32(9):1558-71.
2011: Silvia Casarotto; Olivia Gosseries; Sanna-Kaisa Herukka; Mervi Könönen; Sara Määttä; Esa Mervaala; Martino Napolitani; Eini Niskanen; Andrea Pigorini; Mario Rosanova; Hilkka Soininen; Marcello Massimini
Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging.
Neuroreport 2011;22(12):592-7.
2011: Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo; Kai Kaarniranta; Mikko Hiltunen
AMP-activated protein kinase: a potential player in Alzheimer's disease.
Journal of neurochemistry 2011;118(4):460-74.
2011: Annakaisa Haapasalo; Lars Bertram; Nico P Dantuma; Kaisa Ma Kurkinen; Hilkka Soininen; Rudolph E Tanzi; Jayashree Viswanathan; Mikko Hiltunen
Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.
Communicative & integrative biology 2011;4(4):428-32.
2011: Niklas Mattsson; John McAuliffe; Marc Mercken; Abhay Moghekar; José Luis Molinuevo; Thomas J Montine; William Nowatzke; Richard J O'Brien; Markus Otto; George P Paraskevas; Lucilla Parnetti; Staffan Persson; Ronald C. Petersen; David Prvulovic; Robert A Rissman; Elio Scarpini; Johannes Schröder; Leslie M Shaw; Anders Skinningsrud; Brith Skrogstad; Hilkka Soininen; Annette Spreer; Alessandro Stefani; Leda Talib; Charlotte Teunissen; John Q Trojanowski; Hayrettin Tumani; Robert M Umek; Bianca Van Broeck; hugo Marcel vanderstichele; Laszlo Vecsei; Marcel M Verbeek; Manfred Windisch; Henrik Zetterberg; Jing Zhang; Luisella Bocchio-Chiavetto; Maria C Carrillo; Sonia Chalbot; Davide Chiasserini; Els Coart; Neal Cutler; Gunilla Dahlfors; Herman P M de Reus; Stefan Duller; Anne M Fagan; Orestes Forlenza; Giovanni B Frisoni; Douglas Galasko; Daniela Galimberti; Harald Hampel; Aase Handberg; Michael T Heneka; Adrianna Z Herskovits; Sanna-Kaisa Herukka; David M Holtzman; Christian Humpel; Bradley T Hyman; Khalid Iqbal; Mathias Jucker; Stephan A Kaeser; Elmar Kaiser; Elisabeth Kapaki; Daniel Kidd; Peter Klivenyi; Cindy S Knudsen; Markus P Kummer; Piotr Lewczuk; Qiao-Xin Li; Albert Lladó; James Lui; Ralph Martins; Colin L Masters; Ulf Andreasson; Hiroyuki Arai; Sat Dev Batish; Sergio Bernardini; Marinus A Blankenstein; Kaj Blennow
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):386-395.e6.
2011: Pekka S Miettinen; Eini Niskanen; Maija Pihlajamäki; Tuomo Hänninen; Anne M Jauhiainen; Ritva Vanninen; Hilkka Soininen
Structure and function of medial temporal and posteromedial cortices in early Alzheimer's disease.
The European journal of neuroscience 2011;34(2):320-30.
2011: Antero Salminen; Annakaisa Haapasalo; Mikko Hiltunen; Kai Kaarniranta; Johanna Ojala; Hilkka Soininen
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype.
The European journal of neuroscience 2011;34(1):3-11.
2011: C Tunnard; D Whitehead; C Hurt; Lars-Olof Wahlund; Patrizia Mecocci; M Tsolaki; Bruno Vellas; Christian Spenger; I Kłoszewska; Hilkka Soininen; Simon Lovestone; Andrew Simmons
Apathy and cortical atrophy in Alzheimer's disease.
International journal of geriatric psychiatry 2011;26(7):741-8.
2011: Yawu Liu; Simon Lovestone; Patrizia Mecocci; Sebastian Muehlboeck; Teemu Paajanen; Andrew Simmons; Tomasz Sobow; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Catherine Tunnard; Bruno Vellas; Lars-Olof Wahlund; Eric Westman; Yi Zhang; Alan Evans
Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study.
Neurobiology of aging 2011;32(7):1198-206.
2011: Timo Sarajärvi; Jussi T Tuusa; Annakaisa Haapasalo; Jarkko J Lackman; Raija Sormunen; Seppo Helisalmi; Johannes T Roehr; Antonio R Parrado; Petra Mäkinen; Lars Bertram; Hilkka Soininen; Rudolph E Tanzi; Ulla E Petäjä-Repo; Mikko Hiltunen
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Molecular and cellular biology 2011;31(11):2326-40.
2011: Juha Koikkalainen; Jyrki Lötjönen; Daniel Rueckert; Hilkka Soininen; Lennart Thurfjell; Gunhild Waldemar
Multi-template tensor-based morphometry: application to analysis of Alzheimer's disease.
NeuroImage 2011;56(3):1134-44.
2011: Paul Hollingworth; Peter A Holmans; Clive Holmes; Nigel M Hooper; Michael Hüll; M Arfan Ikram; Dobril Ivanov; Frank Jessen; Karl-Heinz Jöckel; Lesley Jones; Nicola Jones; Palmi V Jonsson; Thorlakur Jonsson; John S K Kauwe; Patrick G Kehoe; Norman Klopp; Heike Kölsch; Johannes Kornhuber; Michael Krawczak; Jean-Charles Lambert; Mark Lathrop; Lenore J Launer; Brian Lawlor; Federico Licastro; Gill Livingston; Oscar L Lopez; Seth Love; Simon Lovestone; Michelle K Lupton; Aoibhinn Lynch; Wolfgang Maier; Michelangelo Mancuso; David Mann; Ignacio Mateo; Manuel Mayhaus; Kevin Mayo; Bernadette McGuinness; Andrew McQuillin; Simon Mead; Susanne Moebus; Kevin Morgan; John C Morris; Valentina Moskvina; Thomas W Mühleisen; Benedetta Nacmias; S Nicolhaus; Markus M Nöthen; Petra Nowotny; Michael O'Donovan; Michael J Owen; Jaspreet Singh Pahwa; V Shane Pankratz; Francesco Panza; Florence Pasquier; Peter A Passmore; Ronald C. Petersen; Paola Piccardi; Alberto Pilotto; Elisa Porcellini; John Powell; Petroula Proitsi; Alex Richards; Caterina Riehle; Matthias Riemenschneider; Martin N Rossor; David C Rubinsztein; Dan Rujescu; Eckart Rüther; Sigrid B Sando; Elio Scarpini; Stefan Schreiber; Britta Schürmann; Davide Seripa; Sudha Seshadri; Christopher E Shaw; Gabriele Siciliano; Rebecca Sims; Andrew B Singleton; Kristel Sleegers; A David Smith; Jon Snaedal; Hilkka Soininen; Vincenzo Solfrizzi; Sandro Sorbi; Hreinn Stefansson; Kari Stefansson; Stacy Steinberg; Alexandra Stretton; Charlene Thomas; Stephen Todd; Magda Tsolaki; Christophe Tzourio; Christine Van Broeckhoven; Hendrik van den Bussche; Cornelia M van Duijn; Emma R L C Vardy; Stefan Wagenpfeil; Donald Warden; H-Erich Wichmann; Caroline Widdowson; Gordon Wilcock; Jan O Aasly; Richard Abraham; Ammar Al-Chalabi; Annick Alpérovitch; Victoria Alvarez; Philippe Amouyel; Giorgio Annoni; Beatrice Arosio; Maria Barcikowska; Nicholas J Bass; Helen Beaumont; Claudine Berr; Karolien Bettens; Sigurbjörn Björnsson; Paolo Bosco; Paola Bossù; Carol Brayne; Monique Breteler; Alexis Brice; Kristelle S Brown; Maria J Bullido; Dominique Campion; Minerva M Carrasquillo; Jade Chapman; Vincent Chouraki; John Collinge; Onofre Combarros; Eliecer Coto; David Craig; Carlos Cruchaga; Jean-François Dartigues; Peter P De Deyn; Marc Delepine; Panagiotis Deloukas; Anita L DeStefano; Martin Dichgans; dennis dickson; Kimberley Dowzell; Sebastiaan Engelborghs; Jacques Epelbaum; Thomas M Feulner; Annette L Fitzpatrick; Nick C Fox; Ana Frank-Garcia; Patricia Friedrich; Lutz Frölich; Daniela Galimberti; John Gallacher; Benjamin Genier-Boley; Amy Gerrish; Ina Giegling; Michael Gill; Alison Goate; Neill R Graff-Radford; Rita Guerreiro; Hugh Gurling; Rhian Gwilliam; Harald Hampel; Marian L Hamshere; Didier Hannequin; Olivier Hanon; John Hardy; Denise Harold; Reiner Heun; Isabella Heuser; Mikko Hiltunen; Jens Wiltfang; Zbigniew K Wszolek; Steven G Younkin; Diana Zelenika; Julie Williams
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Nature genetics 2011;43(5):429-35.
2011: Kristiina Karttunen; Pertti Karppi; Asta Hiltunen; Matti Vanhanen; Tarja Välimäki; Janne Martikainen; Hannu Valtonen; Juhani Sivenius; Hilkka Soininen; Sirpa Hartikainen; Jaana Suhonen; Tuula Pirttilä
Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease.
International journal of geriatric psychiatry 2011;26(5):473-82.
2011: Jyrki Lötjönen; Robin Wolz; Juha Koikkalainen; Valtteri Julkunen; Lennart Thurfjell; Roger Lundqvist; Gunhild Waldemar; Hilkka Soininen; Daniel Rueckert
Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease.
NeuroImage 2011;56(1):185-96.
2011: Sergi G Costafreda; Ivo D Dinov; Zhuowen Tu; Yonggang Shi; Cheng-Yi Liu; Iwona Kloszewska; Patrizia Mecocci; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Christian Spenger; Arthur W Toga; Simon Lovestone; Andrew Simmons
Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment.
NeuroImage 2011;56(1):212-9.
2011: Jean-Charles Lambert; Diana Zelenika; Mikko Hiltunen; Vincent Chouraki; Onofre Combarros; Maria J Bullido; Gloria Tognoni; Nathalie Fiévet; Anne Boland; Beatrice Arosio; Eliecer Coto; Maria Del Zompo; Ignacio Mateo; Ana Frank-Garcia; Seppo Helisalmi; Elisa Porcellini; Alberto Pilotto; Paola Forti; Raffaele Ferri; Marc Delepine; Elio Scarpini; Gabriele Siciliano; Vincenzo Solfrizzi; Sandro Sorbi; Gianfranco Spalletta; Giovanni Ravaglia; Fernando Valdivieso; Victoria Alvarez; Paolo Bosco; Michelangelo Mancuso; Francesco Panza; Benedetta Nacmias; Paola Bossù; Paola Piccardi; Giorgio Annoni; Davide Seripa; Daniela Galimberti; Federico Licastro; Mark Lathrop; Hilkka Soininen; Philippe Amouyel
Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.
Neurobiology of aging 2011;32(4):756.e11-5.
2011: Jayashree Viswanathan; Annakaisa Haapasalo; Claudia Böttcher; Riitta Miettinen; Kaisa M A Kurkinen; Alice Lu; Anne Thomas; Christa J Maynard; Donna Romano; Bradley T Hyman; Oksana Berezovska; Lars Bertram; Hilkka Soininen; Nico P Dantuma; Rudolph E Tanzi; Mikko Hiltunen
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.
Traffic (Copenhagen, Denmark) 2011;12(3):330-48.
2011: Mari Turunen; Saila Vepsäläinen; Petra Mäkinen; Seppo Helisalmi; Annakaisa Haapasalo; Hilkka Soininen; Mikko Hiltunen
No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease.
Neurobiology of aging 2011;32(3):547.e7-9.
2011: Anna-Maija Tolppanen; Seppo Helisalmi; Mikko Hiltunen; Marjukka Kolehmainen; Ursula S Schwab; Tuula Pirttilä; Leena Pulkkinen; Matti Uusitupa; Hilkka Soininen
Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort.
Neurobiology of aging 2011;32(3):546.e7-9.
2011: Eric Westman; Andrew Simmons; Yi Zhang; J-Sebastian Muehlboeck; Catherine Tunnard; Yawu Liu; Louis Collins; Alan Evans; Patrizia Mecocci; Bruno Vellas; Magda Tsolaki; Iwona Kłoszewska; Hilkka Soininen; Simon Lovestone; Christian Spenger; Lars-Olof Wahlund
Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls.
NeuroImage 2011;54(2):1178-87.
2011: Madhav Thambisetty; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Eric Westman; Yi Zhang; James Campbell; Mirsada Causevic; Abdul Hye; Richard Killick; Anna Kinsey; Iwona Kloszewska; Simon Lovestone; Patrizia Mecocci; Andrew Simmons; Hilkka Soininen; Christian Spenger
Plasma biomarkers of brain atrophy in Alzheimer's disease.
PloS one 2011;6(12):e28527.
2011: Eini Niskanen; Ritva Vanninen; Silvia Casarotto; Merja Hallikainen; Jari Karhu; Miia Kivipelto; Mervi Könönen; Sara Määttä; Marcello Massimini; Esa Mervaala; Hilkka Soininen
New insights into Alzheimer's disease progression: a combined TMS and structural MRI study.
PloS one 2011;6(10):e26113.
2011: Robin Wolz; Dong Ping Zhang; Valtteri Julkunen; Juha Koikkalainen; Jyrki Lötjönen; Eini Niskanen; Daniel Rueckert; Hilkka Soininen
Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease.
PloS one 2011;6(10):e25446.
2011: Simon J Furney; Andreas Güntert; Iwona Kloszewska; Deborah Kronenberg; Richard J Dobson; Patrizia Mecocci; Petroula Proitsi; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Simon Lovestone
Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression.
Journal of Alzheimer's disease : JAD 2011;26 Suppl 3():395-405.
2011: Jan Norberg; M Olde Rikkert; A-S Rigaud; Philip scheltens; Hilkka Soininen; Luiza Spiru; Magdalini Tsolaki; Bruno Vellas; F R J Verhey; Ove Almkvist; L S Elias-Sonnenschein; Michael Ewers; Giovanni B Frisoni; L Frölich; Caroline Graff; Harald Hampel; R W Jones; P G Kehoe; HERMINE LENOIR; Lennart Minthon; F Nobili; Lars-Olof Wahlund; Gordon K Wilcock; Pieter Jelle Visser
Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects.
Dementia and geriatric cognitive disorders 2011;32(2):135-42.
2011: Eric Westman; Yi Zhang; Lena Cavallin; Iwona Kłoszewska; Simon Lovestone; Patrizia Mecocci; J-Sebastian Muehlboeck; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund
Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease.
PloS one 2011;6(7):e22506.
2011: Jussi Mattila; Anja Simonsen; Hilkka Soininen; Mark van Gils; Arho Virkki; Gunhild Waldemar; Juha Koikkalainen; Jyrki Lötjönen
A disease state fingerprint for evaluation of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;27(1):163-76.
2011: Hongqian Yang; Yaroslav Lyutvinskiy; Hilkka Soininen; Roman A Zubarev
Alzheimer's disease and mild cognitive impairment are associated with elevated levels of isoaspartyl residues in blood plasma proteins.
Journal of Alzheimer's disease : JAD 2011;27(1):113-8.
2011: Petro Julkunen; Anne M Jauhiainen; Mervi Könönen; Ari Pääkkönen; Jari Karhu; Hilkka Soininen
Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's disease.
International journal of Alzheimer's disease 2011;2011():654794.
2011: J Simon Bell; Anne M Koivisto; Marja-Liisa Laitinen; Piia Lavikainen; Eija Lönnroos; Hilkka Soininen; Sirpa Hartikainen
Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland.
Journal of Alzheimer's disease : JAD 2011;26(2):231-7.
2011: Toni T Seppälä; Hilkka Soininen; Päivi Hartikainen; Seppo Helisalmi; Anne M Koivisto; Sanna-Kaisa Herukka
Longitudinal changes of CSF biomarkers in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;25(4):583-94.
2011: Michelle K Lupton; Petroula Proitsi; Makrina Danillidou; Magda Tsolaki; Gillian Hamilton; Richard Wroe; Megan Pritchard; Kathryn Lord; Belinda M Martin; Iwona Kloszewska; Hilkka Soininen; Patrizia Mecocci; Bruno Vellas; Denise Harold; Paul Hollingworth; Simon Lovestone; John F Powell
Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.
PloS one 2011;6(2):e17298.
2011: Kai Kaarniranta; Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo; Mikko Hiltunen
Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
Journal of Alzheimer's disease : JAD 2011;24(4):615-31.
2011: Miika Vuorinen; A Solomon; Suvi Rovio; Lasse Nieminen; Ingemar Kåreholt; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Changes in vascular risk factors from midlife to late life and white matter lesions: a 20-year follow-up study.
Dementia and geriatric cognitive disorders 2011;31(2):119-25.
2011: Andrew Simmons; Eric Westman; Sebastian Muehlboeck; Patrizia Mecocci; Bruno Vellas; Magda Tsolaki; Iwona Kłoszewska; Lars-Olof Wahlund; Hilkka Soininen; Simon Lovestone; Alan Evans; Christian Spenger
The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months.
International journal of geriatric psychiatry 2011;26(1):75-82.
2011: Antero Salminen; Johanna Ojala; Kai Kaarniranta; Mikko Hiltunen; Hilkka Soininen
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease.
Progress in neurobiology 2011;93(1):99-110.
2010: Suvi Rovio; Gabriela Spulber; Lasse J Nieminen; Eini Niskanen; Bengt Winblad; Jaakko Tuomilehto; Aulikki Nissinen; Hilkka Soininen; Miia Kivipelto
The effect of midlife physical activity on structural brain changes in the elderly.
Neurobiology of aging 2010;31(11):1927-36.
2010: B Hooshmand; A Solomon; Ingemar Kåreholt; J Leiviskä; M Rusanen; S Ahtiluoto; Bengt Winblad; T Laatikainen; Hilkka Soininen; Miia Kivipelto
Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study.
Neurology 2010;75(16):1408-14.
2010: Ville Leinonen; Anne M Koivisto; S Savolainen; Jaana Rummukainen; Juuso N Tamminen; Tomi Tillgren; Sannakaisa Vainikka; Okko T Pyykkö; Juhani Mölsä; Mikael Fraunberg; Tuula Pirttilä; Juha E Jääskeläinen; Hilkka Soininen; Jaakko Rinne; Irina Alafuzoff
Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease.
Annals of neurology 2010;68(4):446-53.
2010: T T Seppälä; S-K Herukka; T Hänninen; S Tervo; M Hallikainen; Hilkka Soininen; T Pirttilä
Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study.
Journal of neurology, neurosurgery, and psychiatry 2010;81(10):1123-7.
2010: Gabriela Spulber; Eini Niskanen; Stuart MacDonald; Oded Smilovici; Kewei Chen; Eric Reiman; Anne M Jauhiainen; Merja Hallikainen; Susanna Tervo; Lars-Olof Wahlund; Ritva Vanninen; Miia Kivipelto; Hilkka Soininen
Whole brain atrophy rate predicts progression from MCI to Alzheimer's disease.
Neurobiology of aging 2010;31(9):1601-5.
2010: Yawu Liu; Teemu Paajanen; Yi Zhang; Eric Westman; Lars-Olof Wahlund; Andrew Simmons; Catherine Tunnard; Tomasz Sobow; Patrizia Mecocci; Magda Tsolaki; Bruno Vellas; Sebastian Muehlboeck; Alan Evans; Christian Spenger; Simon Lovestone; Hilkka Soininen
Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease.
Neurobiology of aging 2010;31(8):1375-85.
2010: Madhav Thambisetty; Andrew Simmons; Latha Velayudhan; Abdul Hye; James Campbell; Yi Zhang; Lars-Olof Wahlund; Eric Westman; Anna Kinsey; Andreas Güntert; Petroula Proitsi; John Powell; Mirsada Causevic; Richard Killick; Katie Lunnon; Steven Lynham; Martin Broadstock; Fahd Choudhry; David R Howlett; Robert J Williams; Sally I Sharp; Cathy Mitchelmore; Catherine Tunnard; Rufina Leung; Catherine Foy; Darragh O'Brien; Gerome Breen; Simon J Furney; Malcolm Ward; Iwona Kloszewska; Patrizia Mecocci; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Angela Hodges; Declan G M Murphy; Sue Parkins; Jill C Richardson; Susan M Resnick; Luigi Ferrucci; Dean F Wong; Yun Zhou; Sebastian Muehlboeck; Alan Evans; Paul T Francis; Christian Spenger; Simon Lovestone
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.
Archives of general psychiatry 2010;67(7):739-48.
2010: Katja Hanisch; Hilkka Soininen; Irina Alafuzoff; Ralf Hoffmann
Analysis of human tau in cerebrospinal fluid.
Journal of proteome research 2010;9(3):1476-82.
2010: C S Hurt; Sube Banerjee; C Tunnard; D L Whitehead; M Tsolaki; P Mecocci; Iwona Kloszewska; Hilkka Soininen; Bruno Vellas; Simon Lovestone
Insight, cognition and quality of life in Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2010;81(3):331-6.
2010: Taher Darreh-Shori; Hilkka Soininen
Effects of cholinesterase inhibitors on the activities and protein levels of cholinesterases in the cerebrospinal fluid of patients with Alzheimer's disease: a review of recent clinical studies.
Current Alzheimer research 2010;7(1):67-73.
2010: Magdalini Tsolaki; Vasileios Papaliagkas; George Anogianakis; R Bernabei; M Emre; L Frolich; P J Visser; J P Michel; T Pirttila; M Olde Rikkert; Hilkka Soininen; T Sobow; Bruno Vellas; F Verhey; Bengt Winblad
Consensus statement on dementia education and training in Europe.
The journal of nutrition, health & aging 2010;14(2):131-5.
2010: Annakaisa Haapasalo; Jayashree Viswanathan; Lars Bertram; Hilkka Soininen; Rudolph E Tanzi; Mikko Hiltunen
Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation.
Biochemical Society transactions 2010;38(Pt 1):150-5.
2010: Jyrki Mp Lötjönen; Robin Wolz; Juha R Koikkalainen; Lennart Thurfjell; Gunhild Waldemar; Hilkka Soininen; Daniel Rueckert
Fast and robust multi-atlas segmentation of brain magnetic resonance images.
NeuroImage 2010;49(3):2352-65.
2010: P Martikainen; Maria Pikkarainen; K Pöntynen; Mikko Hiltunen; Maarit Lehtovirta; S Tuisku; Hilkka Soininen; Irina Alafuzoff
Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation.
Neuropathology and applied neurobiology 2010;36(1):41-54.
2010: Vilmantas Giedraitis; Anna Glaser; Timo Sarajärvi; RoseMarie Brundin; Malin Degerman Gunnarsson; Brit-Maren Schjeide; Rudolph E Tanzi; Seppo Helisalmi; Tuula Pirttilä; Lena Kilander; Lars Lannfelt; Hilkka Soininen; Lars Bertram; Martin Ingelsson; Mikko Hiltunen
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Neuroscience letters 2010;469(2):265-7.
2010: Mark van Gils; Juha Koikkalainen; Jussi Mattila; Sannakaisa Herukka; Jyrki Lotjonen; Hilkka Soininen
Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2010;2010():2886-9.
2010: Teemu Paajanen; Tuomo Hänninen; Catherine Tunnard; Patrizia Mecocci; Tomasz Sobow; Magda Tsolaki; Bruno Vellas; Simon Lovestone; Hilkka Soininen
CERAD neuropsychological battery total score in multinational mild cognitive impairment and control populations: the AddNeuroMed study.
Journal of Alzheimer's disease : JAD 2010;22(4):1089-97.
2010: Philipp Spitzer; Hans-Wolfgang Klafki; Kaj Blennow; Luc BUEE; Hermann Esselmann; Sanna-Kaisa Herruka; Connie Jimenez; Peter Klivenyi; Piotr Lewczuk; Juan Manuel Maler; Katrin Markus; Helmut E Meyer; Chris Morris; Thorsten Müller; Markus Otto; Lucilla Parnetti; Hilkka Soininen; Susanna Schraen; Charlotte Teunissen; Laszlo Vecsei; Henrik Zetterberg; Jens Wiltfang
cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases.
International journal of Alzheimer's disease 2010;2010():.
2010: M Rusanen; S Rovio; T Ngandu; A Nissinen; J Tuomilehto; Hilkka Soininen; M Kivipelto
Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study.
Dementia and geriatric cognitive disorders 2010;30(3):277-84.
2010: Yawu Liu; Teemu Paajanen; Eric Westman; Yi Zhang; Lars-Olof Wahlund; Andrew Simmons; Catherine Tunnard; Tomasz Sobow; Petroula Proitsi; John Powell; Patrizia Mecocci; Magda Tsolaki; Bruno Vellas; Sebastian Muehlboeck; Alan Evans; Christian Spenger; Simon Lovestone; Hilkka Soininen
APOE ε2 allele is associated with larger regional cortical thicknesses and volumes.
Dementia and geriatric cognitive disorders 2010;30(3):229-37.
2010: Jean-Charles Lambert; Kristel Sleegers; Antonio González-Pérez; Martin Ingelsson; Gary Beecham; Mikko Hiltunen; Onofre Combarros; Maria J Bullido; Nathalie Brouwers; Karolien Bettens; Claudine Berr; Florence Pasquier; Florence Richard; Steven T DeKosky; Didier Hannequin; Jonathan L Haines; Gloria Tognoni; Nathalie Fiévet; Jean-François Dartigues; Christophe Tzourio; Sebastiaan Engelborghs; Beatrice Arosio; Elicer Coto; Peter De Deyn; Maria Del Zompo; Ignacio Mateo; Merce Boada; Carmen Antunez; Jesus Lopez-Arrieta; Jacques Epelbaum; Brit-Maren Michaud Schjeide; Ana Frank-Garcia; Vilmentas Giedraitis; Seppo Helisalmi; Elisa Porcellini; Alberto Pilotto; Paola Forti; Raffaele Ferri; Marc Delepine; Diana Zelenika; Mark Lathrop; Elio Scarpini; Gabriele Siciliano; Vincenzo Solfrizzi; Sandro Sorbi; Gianfranco Spalletta; Giovanni Ravaglia; Fernando Valdivieso; Saila Vepsäläinen; Victoria Alvarez; Paolo Bosco; Michelangelo Mancuso; Francesco Panza; Benedetta Nacmias; Paola Bossù; Olivier Hanon; Paola Piccardi; Giorgio Annoni; David Mann; Philippe Marambaud; Davide Seripa; Daniela Galimberti; Rudolph E Tanzi; Lars Bertram; Corinne Lendon; Lars Lannfelt; Federico Licastro; Dominique Campion; Margaret Pericak-Vance; Hilkka Soininen; Christine Van Broeckhoven; Annick Alpérovitch; Agustin Ruiz; M Ilyas Kamboh; Philippe Amouyel
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.
Journal of Alzheimer's disease : JAD 2010;22(1):247-55.
2010: Timo Sarajärvi; Seppo Helisalmi; Leila Antikainen; Petra Mäkinen; Anne Maria Koivisto; Sanna-Kaisa Herukka; Annakaisa Haapasalo; Hilkka Soininen; Mikko Hiltunen
An association study of 21 potential Alzheimer's disease risk genes in a Finnish population.
Journal of Alzheimer's disease : JAD 2010;21(3):763-7.
2010: Yawu Liu; Teemu Paajanen; Eric Westman; Lars-Olof Wahlund; Andrew Simmons; Catherine Tunnard; Tomasz Sobow; Petroula Proitsi; John Powell; Patrizia Mecocci; Magda Tsolaki; Bruno Vellas; Sebastian Muehlboeck; Alan Evans; Christian Spenger; Simon Lovestone; Hilkka Soininen
Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.
Journal of Alzheimer's disease : JAD 2010;21(3):947-66.
2010: A Solomon; R Sippola; Hilkka Soininen; Benjamin Wolozin; Jaakko Tuomilehto; T Laatikainen; Miia Kivipelto
Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK).
Neuro-degenerative diseases 2010;7(1-3):180-2.
2009: Timo Sarajärvi; Annakaisa Haapasalo; Jayashree Viswanathan; Petra Mäkinen; Marjo Laitinen; Hilkka Soininen; Mikko Hiltunen
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
The Journal of biological chemistry 2009;284(49):34433-43.
2009: David Singer; Hilkka Soininen; Irina Alafuzoff; Ralf Hoffmann
Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease.
Analytical and bioanalytical chemistry 2009;395(7):2263-7.
2009: Saila Vepsäläinen; Seppo Helisalmi; Arto Mannermaa; Tuula Pirttilä; Hilkka Soininen; Mikko Hiltunen
Combined risk effects of IDE and NEP gene variants on Alzheimer disease.
Journal of neurology, neurosurgery, and psychiatry 2009;80(11):1268-70.
2009: Alina Solomon; Valerio Leoni; Miia Kivipelto; Ariadna Besga; Anne Rita Oksengård; Per Julin; Leif Svensson; Lars-Olof Wahlund; Niels Andreasen; Bengt Winblad; Hilkka Soininen; Ingemar Björkhem
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.
Neuroscience letters 2009;462(1):89-93.
2009: Andrew Simmons; Eric Westman; Sebastian Muehlboeck; Patrizia Mecocci; Bruno Vellas; Magda Tsolaki; Iwona Kłoszewska; Lars-Olof Wahlund; Hilkka Soininen; Simon Lovestone; Alan Evans; Christian Spenger
MRI measures of Alzheimer's disease and the AddNeuroMed study.
Annals of the New York Academy of Sciences 2009;1180():47-55.
2009: Simon Lovestone; Paul Francis; Iwona Kloszewska; Patrizia Mecocci; Andrew Simmons; Hilkka Soininen; Christian Spenger; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Malcolm Ward
AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.
Annals of the New York Academy of Sciences 2009;1180():36-46.
2009: Jean-Charles Lambert; Simon Heath; Gael Even; Dominique Campion; Kristel Sleegers; Mikko Hiltunen; Onofre Combarros; Diana Zelenika; Maria J Bullido; Béatrice Tavernier; Luc Letenneur; Karolien Bettens; Claudine Berr; Florence Pasquier; Nathalie Fiévet; Pascale Barberger-Gateau; Sebastiaan Engelborghs; Peter De Deyn; Ignacio Mateo; Ana Franck; Seppo Helisalmi; Elisa Porcellini; Olivier Hanon; Marian M de Pancorbo; Corinne Lendon; carole dufouil; Céline Jaillard; Thierry Leveillard; Victoria Alvarez; Paolo Bosco; Michelangelo Mancuso; Francesco Panza; Benedetta Nacmias; Paola Bossù; Paola Piccardi; Giorgio Annoni; Davide Seripa; Daniela Galimberti; Didier Hannequin; Federico Licastro; Hilkka Soininen; Karen Ritchie; Hélène Blanché; Jean-François Dartigues; Christophe Tzourio; Ivo Gut; Christine Van Broeckhoven; Annick Alpérovitch; Mark Lathrop; Philippe Amouyel
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
Nature genetics 2009;41(10):1094-9.
2009: Laura A van de Pol; Frans Verhey; Giovanni B Frisoni; M Tsolaki; P Papapostolou; F Nobili; Lars-Olof Wahlund; L Minthon; Lutz Froelich; Harald Hampel; Hilkka Soininen; Dirk L Knol; Frederik Barkhof; Philip scheltens; Pieter Jelle Visser
White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study.
Journal of neurology, neurosurgery, and psychiatry 2009;80(10):1069-74.
2009: Steven H Ferris; agneta nordberg; Hilkka Soininen; Taher Darreh-Shori; Roger Lane
Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment.
Pharmacogenetics and genomics 2009;19(8):635-46.
2009: Jayashree Viswanathan; Petra Mäkinen; Seppo Helisalmi; Annakaisa Haapasalo; Hilkka Soininen; Mikko Hiltunen
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(5):747-50.
2009: Mikko P Laakso; Susanna Tervo; Tuomo Hänninen; Matti Vanhanen; Merja Hallikainen; Hilkka Soininen
Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(7):891-5.
2009: Pieter Jelle Visser; Frans Verhey; Dirk L Knol; Philip scheltens; Lars-Olof Wahlund; Yvonne Freund-Levi; Magdalini Tsolaki; Lennart Minthon; Asa K Wallin; Harald Hampel; Katharina Bürger; Tuula Pirttila; Hilkka Soininen; Marcel Olde Rikkert; Marcel M Verbeek; Luiza Spiru; Kaj Blennow
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.
Lancet neurology 2009;8(7):619-27.
2009: Mikko Hiltunen; Petra Mäkinen; Sirpa Peräniemi; Juhani Sivenius; Thomas van Groen; Hilkka Soininen; Jukka Jolkkonen
Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.
Neurobiology of disease 2009;35(1):103-13.
2009: Elaine Peskind; agneta nordberg; Taher Darreh-Shori; Hilkka Soininen
Safety of lumbar puncture procedures in patients with Alzheimer's disease.
Current Alzheimer research 2009;6(3):290-2.
2009: A Solomon; Ingemar Kåreholt; Tiia Ngandu; Benjamin Wolozin; S W S Macdonald; Bengt Winblad; Aulikki Nissinen; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Serum total cholesterol, statins and cognition in non-demented elderly.
Neurobiology of aging 2009;30(6):1006-9.
2009: Alice Lu; Mikko Hiltunen; Donna M Romano; Hilkka Soininen; Bradley T Hyman; Lars Bertram; Rudolph E Tanzi
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Maija Pihlajamäki; Anne M Jauhiainen; Hilkka Soininen
Structural and functional MRI in mild cognitive impairment.
Current Alzheimer research 2009;6(2):179-85.
2009: Tero Tapiola; Irina Alafuzoff; Sanna-Kaisa Herukka; Laura Parkkinen; Päivi Hartikainen; Hilkka Soininen; Tuula Pirttilä
Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.
Archives of neurology 2009;66(3):382-9.
2009: agneta nordberg; Taher Darreh-Shori; Elaine Peskind; Hilkka Soininen; Malahat Mousavi; Gina Eagle; Roger Lane
Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.
Current Alzheimer research 2009;6(1):4-14.
2009: Anne M Jauhiainen; Maija Pihlajamäki; Susanna Tervo; Eini Niskanen; Heikki Tanila; Tuomo Hänninen; Ritva Vanninen; Hilkka Soininen
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment.
Hippocampus 2009;19(2):166-75.
2009: Irina Alafuzoff; L Aho; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen
Beta-amyloid deposition in brains of subjects with diabetes.
Neuropathology and applied neurobiology 2009;35(1):60-8.
2009: Matej Oresic; Jyrki Lötjönen; Hilkka Soininen
Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease.
Genome medicine 2009;1(11):83.
2009: Valtteri Julkunen; Eini Niskanen; Sebastian Muehlboeck; Maija Pihlajamäki; Mervi Könönen; Merja Hallikainen; Miia Kivipelto; Susanna Tervo; Ritva Vanninen; Alan Evans; Hilkka Soininen
Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease.
Dementia and geriatric cognitive disorders 2009;28(5):404-12.
2009: Krister Håkansson; Suvi Rovio; Eeva-Liisa Helkala; Anna-Riitta Vilska; Bengt Winblad; Hilkka Soininen; Aulikki Nissinen; Abdul H Mohammed; Miia Kivipelto
Association between mid-life marital status and cognitive function in later life: population based cohort study.
BMJ (Clinical research ed.) 2009;339():b2462.
2009: Seppo Helisalmi; Antti Väkevä; Mikko Hiltunen; Hilkka Soininen
Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease.
Dementia and geriatric cognitive disorders 2009;27(4):318-21.
2009: Marjo H Eskelinen; Tiia Ngandu; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.
Journal of Alzheimer's disease : JAD 2009;16(1):85-91.
2008: Lars Bertram; Brit-Maren M Schjeide; Basavaraj Hooli; Kristina Mullin; Mikko Hiltunen; Hilkka Soininen; Martin Ingelsson; Lars Lannfelt; Deborah Blacker; Rudolph E Tanzi
No association between CALHM1 and Alzheimer's disease risk.
Cell 2008;135(6):993-4; author reply 994-6.
2008: Miia Kivipelto; Suvi Rovio; Tiia Ngandu; Ingemar Kåreholt; Marjo Eskelinen; Bengt Winblad; vladimir hachinski; Angel Cedazo-Minguez; Hilkka Soininen; Jaakko Tuomilehto; Aulikki Nissinen
Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study.
Journal of cellular and molecular medicine 2008;12(6B):2762-71.
2008: Taru Tukiainen; Tuulia Tynkkynen; Ville-Petteri Mäkinen; Pasi Jylänki; Antti Kangas; Johanna Hokkanen; Aki Vehtari; Olli Gröhn; Merja Hallikainen; Hilkka Soininen; Miia Kivipelto; Per-Henrik Groop; Kimmo Kaski; Reino Laatikainen; Pasi Soininen; Tuula Pirttilä; Mika Ala-Korpela
A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.
Biochemical and biophysical research communications 2008;375(3):356-61.
2008: Ville Leinonen; Irina Alafuzoff; Sargo Aalto; Timo Suotunen; S Savolainen; Kjell Någren; Tero Tapiola; Tuula Pirttilä; Jaakko Rinne; Juha E Jääskeläinen; Hilkka Soininen; Juha O Rinne
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.
Archives of neurology 2008;65(10):1304-9.
2008: Jari Tiihonen; Roberta Rossi; Mikko P Laakso; Sheilagh Hodgins; Cristina Testa; Jorge Perez; Eila Repo-Tiihonen; Olli Vaurio; Hilkka Soininen; Hannu J Aronen; Mervi Könönen; Paul M Thompson; Giovanni B Frisoni
Brain anatomy of persistent violent offenders: more rather than less.
Psychiatry research 2008;163(3):201-12.
2008: Seppo Helisalmi; Timo Tarvainen; Saila Vepsäläinen; Anne Maria Koivisto; Mikko Hiltunen; Hilkka Soininen
Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease.
Neuroscience letters 2008;441(2):233-6.
2008: Petro Julkunen; Anne M Jauhiainen; Susanna Westerén-Punnonen; Eriikka Pirinen; Hilkka Soininen; Mervi Könönen; Ari Pääkkönen; Sara Määttä; Jari Karhu
Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: a pilot study.
Journal of neuroscience methods 2008;172(2):270-6.
2008: Marjo H Eskelinen; Tiia Ngandu; Eeva-Liisa Helkala; Jaakko Tuomilehto; Aulikki Nissinen; Hilkka Soininen; Miia Kivipelto
Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study.
International journal of geriatric psychiatry 2008;23(7):741-7.
2008: Saila Vepsäläinen; Mikko Hiltunen; Seppo Helisalmi; Jun Wang; Thomas van Groen; Heikki Tanila; Hilkka Soininen
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.
Neuroscience letters 2008;438(2):216-20.
2008: R Lämsä; Seppo Helisalmi; Sanna-Kaisa Herukka; Tero Tapiola; Tuula Pirttilä; Saila Vepsäläinen; M Hiltunen; Hilkka Soininen
Genetic study evaluating LDLR polymorphisms and Alzheimer's disease.
Neurobiology of aging 2008;29(6):848-55.
2008: Sanna-Kaisa Herukka; Corina Pennanen; Hilkka Soininen; Tuula Pirttilä
CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy.
Journal of Alzheimer's disease : JAD 2008;14(1):51-7.
2008: Seppo Helisalmi; Saila Vepsäläinen; Mikko Hiltunen; Anne Maria Koivisto; A Salminen; M Laakso; Hilkka Soininen
Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.
Journal of neurology 2008;255(5):668-73.
2008: Roger Lane; Howard H Feldman; Joanne Meyer; Yunsheng He; Steven H Ferris; agneta nordberg; Taher Darreh-Shori; Hilkka Soininen; Tuula Pirttilä; Martin R Farlow; Nikolaos Sfikas; Clive G Ballard; Nigel H Greig
Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.
Pharmacogenetics and genomics 2008;18(4):289-98.
2008: Elin S Blom; Jayashree Viswanathan; Lena Kilander; Seppo Helisalmi; Hilkka Soininen; Lars Lannfelt; Martin Ingelsson; Anna Glaser; Mikko Hiltunen
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease.
European journal of human genetics : EJHG 2008;16(2):171-5.
2008: Susanna Mäkinen; Thomas van Groen; Jared Clarke; Anders Thornell; Dale Corbett; Mikko Hiltunen; Hilkka Soininen; Jukka Jolkkonen
Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):263-8.
2008: Anne M Jauhiainen; Tuija Kangasmaa; Minna Rusanen; Eini Niskanen; Susanna Tervo; Miia Kivipelto; Ritva L Vanninen; Jyrki T Kuikka; Hilkka Soininen
Differential hypometabolism patterns according to mild cognitive impairment subtypes.
Dementia and geriatric cognitive disorders 2008;26(6):490-8.
2008: Jussi Koivunen; T Pirttilä; Nina Kemppainen; S Aalto; S-K Herukka; A M Jauhianen; T Hänninen; M Hallikainen; Kjell Någren; Juha O Rinne; Hilkka Soininen
PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment.
Dementia and geriatric cognitive disorders 2008;26(4):378-83.
2008: Gabor Geza Kovacs; Irina Alafuzoff; Safa Al-Sarraj; Thomas Arzberger; Nenad Bogdanovic; Sabina Capellari; Isidro Ferrer; Ellen Gelpi; Viktor Kövari; Hans A Kretzschmar; Zoltan Nagy; Piero Parchi; Danielle Seilhean; Hilkka Soininen; Claire Troakes; Herbert Budka
Mixed brain pathologies in dementia: the BrainNet Europe consortium experience.
Dementia and geriatric cognitive disorders 2008;26(4):343-50.
2008: P J Visser; Frans Verhey; M Boada; R Bullock; P P De Deyn; Giovanni B Frisoni; L Frolich; Harald Hampel; J Jolles; R Jones; L Minthon; F Nobili; Marcel G M Olde Rikkert; Pierre-Jean Ousset; A-S Rigaud; Philip scheltens; Hilkka Soininen; Luiza Spiru; J Touchon; Magdalini Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Gordon K Wilcock; Bengt Winblad
Development of screening guidelines and clinical criteria for predementia Alzheimer's disease. The DESCRIPA Study.
Neuroepidemiology 2008;30(4):254-65.
2008: Anne Hämäläinen; Marta Grau-Olivares; Susanna Tervo; Eini Niskanen; Corina Pennanen; J Huuskonen; Miia Kivipelto; Tuomo Hänninen; M Tapiola; Matti Vanhanen; Merja Hallikainen; Eeva-Liisa Helkala; Aulikki Nissinen; Ritva Vanninen; Hilkka Soininen
Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.
Neuro-degenerative diseases 2008;5(3-4):186-9.
2008: Tero Tapiola; Corina Pennanen; Mia Tapiola; Susanna Tervo; Miia Kivipelto; Tuomo Hänninen; Maija Pihlajamäki; Mikko P Laakso; Merja Hallikainen; Anne Hämäläinen; Matti Vanhanen; Eeva-Liisa Helkala; Ritva Vanninen; Aulikki Nissinen; Roberta Rossi; Giovanni B Frisoni; Hilkka Soininen
MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study.
Neurobiology of aging 2008;29(1):31-8.
2007: Paraskevi Sakka; Magdalini Tsolaki; Jakub Hort; Klaus Hager; Hilkka Soininen; Secundino López-Pousa; Chunming Li; Elias Schwam
Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy.
Current medical research and opinion 2007;23(12):3153-65.
2007: Anne Hämäläinen; Maija Pihlajamäki; Heikki Tanila; Tuomo Hänninen; Eini Niskanen; Susanna Tervo; Pasi A Karjalainen; Ritva Vanninen; Hilkka Soininen
Increased fMRI responses during encoding in mild cognitive impairment.
Neurobiology of aging 2007;28(12):1889-903.
2007: Saila Vepsäläinen; Seppo Helisalmi; Anne Maria Koivisto; Toni Tapaninen; Mikko Hiltunen; Hilkka Soininen
Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients.
Journal of neurology 2007;254(11):1504-8.
2007: R Lämsä; Seppo Helisalmi; Mikko Hiltunen; Sanna-Kaisa Herukka; Tero Tapiola; Tuula Pirttilä; Saila Vepsäläinen; Hilkka Soininen
The association study between DHCR24 polymorphisms and Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):906-10.
2007: Tiia Ngandu; Eva von Strauss; Eeva-Liisa Helkala; Bengt Winblad; Aulikki Nissinen; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Education and dementia: what lies behind the association?
Neurology 2007;69(14):1442-50.
2007: Jared Clarke; Anders Thornell; Dale Corbett; Hilkka Soininen; Mikko Hiltunen; Jukka Jolkkonen
Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats.
The European journal of neuroscience 2007;26(7):1845-52.
2007: Anne Hämäläinen; Susanna Tervo; Marta Grau-Olivares; Eini Niskanen; Corina Pennanen; Jari Huuskonen; Miia Kivipelto; Tuomo Hänninen; Mia Tapiola; Matti Vanhanen; Merja Hallikainen; Eeva-Liisa Helkala; Aulikki Nissinen; Ritva Vanninen; Hilkka Soininen
Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment.
NeuroImage 2007;37(4):1122-31.
2007: Suvi Rovio; Ingemar Kåreholt; Matti Viitanen; Bengt Winblad; Jaakko Tuomilehto; Hilkka Soininen; Aulikki Nissinen; Miia Kivipelto
Work-related physical activity and the risk of dementia and Alzheimer's disease.
International journal of geriatric psychiatry 2007;22(9):874-82.
2007: Saila Vepsäläinen; Michele Parkinson; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen; Rudolph E Tanzi; Lars Bertram; Mikko Hiltunen
Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
Journal of medical genetics 2007;44(9):606-8.
2007: Sanna-Kaisa Herukka; Seppo Helisalmi; Merja Hallikainen; Susanna Tervo; Hilkka Soininen; Tuula Pirttilä
CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI.
Neurobiology of aging 2007;28(4):507-14.
2007: A Solomon; Ingemar Kåreholt; Tiia Ngandu; Bengt Winblad; Aulikki Nissinen; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study.
Neurology 2007;68(10):751-6.
2007: Christian C Joyal; Anu Putkonen; A Mancini-Marïe; Sheilagh Hodgins; M Kononen; Luc Boulay; M Pihlajamaki; Hilkka Soininen; Emmanuel Stip; Jari Tiihonen; Hannu J Aronen
Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study.
Schizophrenia research 2007;91(1-3):97-102.
2007: Eini Niskanen; Mika P Tarvainen; Mervi Kononen; Hilkka Soininen; Pasi A Karjalainen
Subspace approaches for FMRI time series estimation.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2007;2007():5485-8.
2007: R Lamsa; Seppo Helisalmi; Sanna-Kaisa Herukka; Tero Tapiola; T Pirttila; S Vepsalainen; Mikko Hiltunen; Hilkka Soininen
Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers.
Dementia and geriatric cognitive disorders 2007;24(2):146-50.
2007: Tiia Ngandu; Eeva-Liisa Helkala; Hilkka Soininen; Bengt Winblad; Jaakko Tuomilehto; Aulikki Nissinen; Miia Kivipelto
Alcohol drinking and cognitive functions: findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study.
Dementia and geriatric cognitive disorders 2007;23(3):140-9.
2007: Hilkka Soininen; Christine West; Jeffery Robbins; Liviu Niculescu
Long-term efficacy and safety of celecoxib in Alzheimer's disease.
Dementia and geriatric cognitive disorders 2007;23(1):8-21.
2006: Katharina Buerger; Michael Ewers; Tuula Pirttilä; Raymond Zinkowski; Irina Alafuzoff; Stefan J Teipel; John DeBernardis; Daniel Kerkman; Cheryl McCulloch; Hilkka Soininen; Harald Hampel
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):3035-41.
2006: Matti Vanhanen; Keijo Koivisto; Leena Moilanen; Eeva-Liisa Helkala; Tuomo Hänninen; Hilkka Soininen; Kari Kervinen; Y Antero Kesäniemi; Markku Laakso; Johanna Kuusisto
Association of metabolic syndrome with Alzheimer disease: a population-based study.
Neurology 2006;67(5):843-7.
2006: Miia Kivipelto; Tiia Ngandu; Tiina Laatikainen; Bengt Winblad; Hilkka Soininen; Jaakko Tuomilehto
Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study.
Lancet neurology 2006;5(9):735-41.
2006: Xin-Wen Zhou; Xu Li; Cecilia Bjorkdahl; Magnus J Sjogren; Irina Alafuzoff; Hilkka Soininen; Inge Grundke-Iqbal; Khalid Iqbal; Bengt Winblad; Jin-Jing Pei
Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains.
Neurobiology of disease 2006;22(3):657-68.
2006: Linus Jönsson; Maria Eriksdotter-Jönhagen; Lena Kilander; Hilkka Soininen; Merja Hallikainen; Gunhild Waldemar; Harald Nygaard; Niels Andreasen; Bengt Winblad; Anders Wimo
Determinants of costs of care for patients with Alzheimer's disease.
International journal of geriatric psychiatry 2006;21(5):449-59.
2006: Mikko Hiltunen; Susan Iivonen; Hilkka Soininen
Aromatase enzyme and Alzheimer's disease.
Minerva endocrinologica 2006;31(1):61-73.
2006: Seppo Helisalmi; Saila Vepsäläinen; Anne Maria Koivisto; Arto Mannermaa; Susan Iivonen; Mikko Hiltunen; V Kiviniemi; Hilkka Soininen
Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary.
Journal of neurology, neurosurgery, and psychiatry 2006;77(3):421-2.
2006: Anne Maria Koivisto; Seppo Helisalmi; Jussi Pihlajamaki; Mikko Hiltunen; Keijo Koivisto; Leena Moilanen; Johanna Kuusisto; Eeva-Liisa Helkala; Tuomo Hanninen; Kari Kervinen; Y Antero Kesaniemi; Markku Laakso; Hilkka Soininen
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.
Dementia and geriatric cognitive disorders 2006;22(5-6):449-53.
2006: M H Laitinen; Tiia Ngandu; Suvi Rovio; Eeva-Liisa Helkala; Ulla Uusitalo; Matti Viitanen; Aulikki Nissinen; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study.
Dementia and geriatric cognitive disorders 2006;22(1):99-107.
2006: Corina Pennanen; Cristina Testa; Marina Boccardi; Mikko P Laakso; Merja Hallikainen; Eeva-Liisa Helkala; Tuomo Hänninen; Miia Kivipelto; Mervi Könönen; Aulikki Nissinen; Susanna Tervo; Matti Vanhanen; Ritva Vanninen; Giovanni B Frisoni; Hilkka Soininen
The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.
Dementia and geriatric cognitive disorders 2006;22(1):60-6.
2006: Bengt Winblad; Anders Wimo; Knut Engedal; Hilkka Soininen; Frans Verhey; Gunhild Waldemar; Anna-Lena Wetterholm; Anders Haglund; Richard Zhang; R Schindler
3-year study of donepezil therapy in Alzheimer's disease: effects of early and continuous therapy.
Dementia and geriatric cognitive disorders 2006;21(5-6):353-63.
2006: Linus Jönsson; Niels Andreasen; Lena Kilander; Hilkka Soininen; Gunhild Waldemar; Harald Nygaard; Bengt Winblad; Maria Eriksdotter Jönhagen; Merja Hallikainen; Anders Wimo
Patient- and proxy-reported utility in Alzheimer disease using the EuroQoL.
Alzheimer disease and associated disorders 2006;20(1):49-55.
2006: Susan Iivonen; Taneli Heikkinen; Jukka Puoliväli; Seppo Helisalmi; Mikko Hiltunen; Hilkka Soininen; Heikki Tanila
Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice.
Neuroscience 2006;137(4):1143-52.
2005: Khalid Iqbal; Michael Flory; Sabiha Khatoon; Hilkka Soininen; Tuula Pirttila; Maarit Lehtovirta; Irina Alafuzoff; Kaj Blennow; Niels Andreasen; Eugeen Vanmechelen; Inge Grundke-Iqbal
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.
Annals of neurology 2005;58(5):748-57.
2005: Suvi Rovio; Ingemar Kåreholt; Eeva-Liisa Helkala; Matti Viitanen; Bengt Winblad; Jaakko Tuomilehto; Hilkka Soininen; Aulikki Nissinen; Miia Kivipelto
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.
Lancet neurology 2005;4(11):705-11.
2005: Maija Pihlajamäki; Heikki Tanila; Mervi Könönen; Tuomo Hänninen; Hannu J Aronen; Hilkka Soininen
Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects.
The European journal of neuroscience 2005;22(8):2095-105.
2005: Miia Kivipelto; Tiia Ngandu; Laura Fratiglioni; Matti Viitanen; Ingemar Kåreholt; Bengt Winblad; Eeva-Liisa Helkala; Jaakko Tuomilehto; Hilkka Soininen; Aulikki Nissinen
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.
Archives of neurology 2005;62(10):1556-60.
2005: Riitta Miettinen; Anett Riedel; Giedrius Kalesnykas; Hannu-Pekka Kettunen; Jukka Puoliväli; Hilkka Soininen; Thomas Arendt
Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy.
Journal of chemical neuroanatomy 2005;30(2-3):105-18.
2005: Mia Pirskanen; Mikko Hiltunen; Arto Mannermaa; Seppo Helisalmi; Maarit Lehtovirta; Tuomo Hänninen; Hilkka Soininen
Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women.
European journal of human genetics : EJHG 2005;13(9):1000-6.
2005: Xu Li; Irina Alafuzoff; Hilkka Soininen; Bengt Winblad; Jin-Jing Pei
Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain.
The FEBS journal 2005;272(16):4211-20.
2005: Anne Maria Koivisto; Seppo Helisalmi; Jussi Pihlajamäki; Leena Moilanen; Johanna Kuusisto; Markku Laakso; Mikko Hiltunen; Koivisto Keijo; Tuomo Hänninen; Eeva-Liisa Helkala; Kari Kervinen; Y Antero Kesäniemi; Hilkka Soininen
Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.
Journal of neurogenetics 2005;19(3-4):155-61.
2005: Sanna-Kaisa Herukka; Merja Hallikainen; Hilkka Soininen; Tuula Pirttilä
CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment.
Neurology 2005;64(7):1294-7.
2005: Saila Vepsäläinen; Eero Castren; Seppo Helisalmi; Susan Iivonen; Arto Mannermaa; Maarit Lehtovirta; Tuomo Hänninen; Hilkka Soininen; Mikko Hiltunen
Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease.
Journal of neurology 2005;252(4):423-8.
2005: Lorena Bresciani; Roberta Rossi; Cristina Testa; Cristina Geroldi; Samantha Galluzzi; Mikko P Laakso; Alberto Beltramello; Hilkka Soininen; Giovanni B Frisoni
Visual assessment of medial temporal atrophy on MR films in Alzheimer's disease: comparison with volumetry.
Aging clinical and experimental research 2005;17(1):8-13.
2005: J D Chaudhuri; Mikko Hiltunen; M Nykänen; S Ylä-Herttuala; Hilkka Soininen; Riitta Miettinen
Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods.
Neuroscience 2005;131(2):557-66.
2005: Giovanni B Frisoni; Cristina Testa; Francesca Sabattoli; Alberto Beltramello; Hilkka Soininen; Mikko P Laakso
Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study.
Journal of neurology, neurosurgery, and psychiatry 2005;76(1):112-4.
2005: Corina Pennanen; Cristina Testa; Mikko P Laakso; Merja Hallikainen; Eeva-Liisa Helkala; Tuomo Hänninen; Miia Kivipelto; M Könönen; A Nissinen; Susanna Tervo; Matti Vanhanen; R Vanninen; Giovanni B Frisoni; Hilkka Soininen
A voxel based morphometry study on mild cognitive impairment.
Journal of neurology, neurosurgery, and psychiatry 2005;76(1):11-4.
2005: Marina Boccardi; Francesca Sabattoli; Mikko P Laakso; Cristina Testa; Roberta Rossi; Alberto Beltramello; Hilkka Soininen; Giovanni B Frisoni
Frontotemporal dementia as a neural system disease.
Neurobiology of aging 2005;26(1):37-44.
2004: Seppo Helisalmi; Mikko Hiltunen; Saila Vepsäläinen; Susan Iivonen; Arto Mannermaa; Maarit Lehtovirta; Anne Maria Koivisto; Irina Alafuzoff; Hilkka Soininen
Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients.
Journal of neurology, neurosurgery, and psychiatry 2004;75(12):1746-8.
2004: Xu Li; Wen-Lin An; Irina Alafuzoff; Hilkka Soininen; Bengt Winblad; Jin-Jing Pei
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain.
Neuroreport 2004;15(14):2237-40.
2004: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons.
Neuroscience letters 2004;368(2):181-5.
2004: Tiia Anttila; Eeva-Liisa Helkala; Matti Viitanen; Ingemar Kåreholt; Laura Fratiglioni; Bengt Winblad; Hilkka Soininen; Jaakko Tuomilehto; Aulikki Nissinen; Miia Kivipelto
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study.
BMJ (Clinical research ed.) 2004;329(7465):539.
2004: Seppo Helisalmi; Mikko Hiltunen; Saila Vepsäläinen; Susan Iivonen; Elizabeth H Corder; Maarit Lehtovirta; Arto Mannermaa; Anne Maria Koivisto; Hilkka Soininen
Genetic variation in apolipoprotein D and Alzheimer's disease.
Journal of neurology 2004;251(8):951-7.
2004: Seppo Helisalmi; Bart Dermaut; Mikko Hiltunen; Arto Mannermaa; Marleen Van den Broeck; Maarit Lehtovirta; Anne Maria Koivisto; Susan Iivonen; Marc Cruts; Hilkka Soininen; Christine Van Broeckhoven
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
Neurology 2004;63(1):173-5.
2004: Jaana M Autere; Jukka S Moilanen; Saara Finnilä; Hilkka Soininen; Arto Mannermaa; Päivi Hartikainen; Merja Hallikainen; Kari Majamaa
Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia.
Human genetics 2004;115(1):29-35.
2004: Susan Iivonen; E Corder; Maarit Lehtovirta; Seppo Helisalmi; Arto Mannermaa; Saila Vepsäläinen; Tuomo Hänninen; Hilkka Soininen; Mikko Hiltunen
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease.
Neurology 2004;62(7):1170-6.
2004: Maija Pihlajamäki; Heikki Tanila; Mervi Könönen; Tuomo Hänninen; Anne Hämäläinen; Hilkka Soininen; Hannu J Aronen
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans.
The European journal of neuroscience 2004;19(7):1939-49.
2004: Corina Pennanen; Miia Kivipelto; Susanna Tuomainen; Päivi Hartikainen; Tuomo Hänninen; Mikko P Laakso; Merja Hallikainen; Matti Vanhanen; Aulikki Nissinen; Eeva-Liisa Helkala; Pauli Vainio; Ritva Vanninen; Kaarina Partanen; Hilkka Soininen
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD.
Neurobiology of aging 2004;25(3):303-10.
2004: Cristina Testa; Mikko P Laakso; Francesca Sabattoli; Roberta Rossi; Alberto Beltramello; Hilkka Soininen; Giovanni B Frisoni
A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease.
Journal of magnetic resonance imaging : JMRI 2004;19(3):274-82.
2004: Pirkko Ruoppi; Tiina Koistinen; P Susitaival; J Honkanen; Hilkka Soininen
Frequency of allergic rhinitis to laboratory animals in university employees as confirmed by chamber challenges.
Allergy 2004;59(3):295-301.
2004: Marina Boccardi; Francesca Sabattoli; Cristina Testa; Alberto Beltramello; Hilkka Soininen; Giovanni B Frisoni
APOE and modulation of Alzheimer's and frontotemporal dementia.
Neuroscience letters 2004;356(3):167-70.
2004: Corina Pennanen; Mikko P Laakso; Miia Kivipelto; J Ramberg; Hilkka Soininen
Serum testosterone levels in males with Alzheimer's disease.
Journal of neuroendocrinology 2004;16(2):95-8.
2004: Mikko Hiltunen; Seppo Helisalmi; Miia Kivipelto; Hilkka Soininen
[Genetics of Alzheimer's disease].
Duodecim; lääketieteellinen aikakauskirja 2004;120(20):2425-31.
2004: Susanna Tervo; Miia Kivipelto; Tuomo Hänninen; Matti Vanhanen; Merja Hallikainen; Arto Mannermaa; Hilkka Soininen
Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects.
Dementia and geriatric cognitive disorders 2004;17(3):196-203.
2004: Roy W Jones; Hilkka Soininen; Klaus Hager; Dag Aarsland; Peter Passmore; Anita Murthy; Richard Zhang; Ranbir Bahra
A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease.
International journal of geriatric psychiatry 2004;19(1):58-67.
2003: Susan Iivonen; Seppo Helisalmi; Arto Mannermaa; Irina Alafuzoff; Maarit Lehtovirta; Hilkka Soininen; Mikko Hiltunen
Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology.
Neuroscience letters 2003;352(2):146-50.
2003: Giovanni B Frisoni; Philip scheltens; Samantha Galluzzi; Flavio Nobili; Nick C Fox; P H Robert; Hilkka Soininen; Lars-Olof Wahlund; G Waldemar; E Salmon
Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC.
Journal of neurology, neurosurgery, and psychiatry 2003;74(10):1371-81.
2003: Anett Riedel; Riitta Miettinen; Jens Stieler; Mia Mikkonen; Irina Alafuzoff; Hilkka Soininen; Thomas Arendt
Reelin-immunoreactive Cajal-Retzius cells: the entorhinal cortex in normal aging and Alzheimer's disease.
Acta neuropathologica 2003;106(4):291-302.
2003: Laura Parkkinen; Hilkka Soininen; Irina Alafuzoff
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.
Journal of neuropathology and experimental neurology 2003;62(4):363-7.
2003: Mikko P Laakso; Y Hiltunen; Mervi Könönen; Miia Kivipelto; A Koivisto; Merja Hallikainen; Hilkka Soininen
Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(3):267-75.
2003: Kari M Mattila; Mikko Hiltunen; Juha O Rinne; Arto Mannermaa; Matias Röyttä; Irina Alafuzoff; Pekka Laippala; Hilkka Soininen; Terho Lehtimäki
Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients.
Neuroscience letters 2003;337(1):61-3.
2003: Maija Pihlajamäki; Heikki Tanila; Tuomo Hänninen; Mervi Könönen; Mia Mikkonen; Ville Jalkanen; Kaarina Partanen; Hannu J Aronen; Hilkka Soininen
Encoding of novel picture pairs activates the perirhinal cortex: an fMRI study.
Hippocampus 2003;13(1):67-80.
2003: Marina Boccardi; Mikko P Laakso; Lorena Bresciani; Samantha Galluzzi; Cristina Geroldi; Alberto Beltramello; Hilkka Soininen; Giovanni B Frisoni
The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia.
Neurobiology of aging 2003;24(1):95-103.
2003: Anders Wimo; Bengt Winblad; Knut Engedal; Hilkka Soininen; Frans Verhey; Gunhild Waldemar; Anna-Lena Wetterholm; Vera Mastey; Anders Haglund; Richard Zhang; Robert Miceli; Warren Chin; Ponni Subbiah
An economic evaluation of donepezil in mild to moderate Alzheimer's disease: results of a 1-year, double-blind, randomized trial.
Dementia and geriatric cognitive disorders 2003;15(1):44-54.
2002: Marina Boccardi; Corina Pennanen; Mikko P Laakso; Cristina Testa; Cristina Geroldi; Hilkka Soininen; Giovanni B Frisoni
Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease.
Neuroscience letters 2002;335(2):139-43.
2002: Eeva-Liisa Helkala; Miia Kivipelto; Merja Hallikainen; Kari Alhainen; H Heinonen; Jaakko Tuomilehto; Hilkka Soininen; Aulikki Nissinen
Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure--a population-based study.
Acta neurologica Scandinavica 2002;106(6):341-6.
2002: Giovanni B Frisoni; Cristina Testa; A Zorzan; Francesca Sabattoli; Alberto Beltramello; Hilkka Soininen; Mikko P Laakso
Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry.
Journal of neurology, neurosurgery, and psychiatry 2002;73(6):657-64.
2002: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Biochemical and biophysical research communications 2002;298(5):693-8.
2002: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.
Brain research. Molecular brain research 2002;106(1-2):50-6.
2002: T Anttila; Eeva-Liisa Helkala; Miia Kivipelto; Merja Hallikainen; Kari Alhainen; H Heinonen; Arto Mannermaa; Jaakko Tuomilehto; Hilkka Soininen; Aulikki Nissinen
Midlife income, occupation, APOE status, and dementia: a population-based study.
Neurology 2002;59(6):887-93.
2002: Jaana M Autere; Mikko J Hiltunen; Arto Mannermaa; Pekka Jäkälä; Päivi Hartikainen; Kari Majamaa; Irina Alafuzoff; Hilkka Soininen
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson's disease in Finland.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2002;9(5):479-83.
2002: Tuomo Hänninen; Merja Hallikainen; Susanna Tuomainen; Matti Vanhanen; Hilkka Soininen
Prevalence of mild cognitive impairment: a population-based study in elderly subjects.
Acta neurologica Scandinavica 2002;106(3):148-54.
2002: Miia Kivipelto; Eeva-Liisa Helkala; Mikko P Laakso; Tuomo Hänninen; Merja Hallikainen; Kari Alhainen; Susan Iivonen; Arto Mannermaa; Jaakko Tuomilehto; Aulikki Nissinen; Hilkka Soininen
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.
Annals of internal medicine 2002;137(3):149-55.
2002: Mikko P Laakso; Faith Gunning-Dixon; Olli Vaurio; Eila Repo-Tiihonen; Hilkka Soininen; Jari Tiihonen
Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism.
Psychiatry research 2002;114(2):95-102.
2002: Miia Kivipelto; Hilkka Soininen; Jaakko Tuomilehto
Hypertension and white matter lesions of the brain.
Journal of hypertension 2002;20(3):387-9.
2002: Ina Tarkka; M Lehtovirta; Hilkka Soininen; Ari Pääkkönen; Jari Karhu; J Partanen
Auditory adaptation is differentially impaired in familial and sporadic Alzheimer's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(1):45-9.
2002: Mia Pirskanen; Mikko Hiltunen; Arto Mannermaa; Susan Iivonen; Seppo Helisalmi; Maarit Lehtovirta; Anne Maria Koivisto; Markku Laakso; Hilkka Soininen; Irina Alafuzoff
Interleukin 1 alpha gene polymorphism as a susceptibility factor in Alzheimer's disease and its influence on the extent of histopathological hallmark lesions of Alzheimer's disease.
Dementia and geriatric cognitive disorders 2002;14(3):123-7.
2002: Susan Iivonen; Mikko Hiltunen; Irina Alafuzoff; Arto Mannermaa; Petri Kerokoski; Jukka Puoliväli; Antero Salminen; Seppo Helisalmi; Hilkka Soininen
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease.
Neuroscience 2002;113(2):301-10.
2002: Miia Kivipelto; Mikko P Laakso; Jaakko Tuomilehto; Aulikki Nissinen; Hilkka Soininen
Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention.
CNS drugs 2002;16(7):435-44.
2002: Giovanni B Frisoni; Cristina Geroldi; Alberto Beltramello; Angelo Bianchetti; Giuliano Binetti; Giovanni Bordiga; Charles DeCarli; Mikko P Laakso; Hilkka Soininen; Cristina Testa; Orazio Zanetti; Marco Trabucchi
Radial width of the temporal horn: a sensitive measure in Alzheimer disease.
AJNR. American journal of neuroradiology 2002;23(1):35-47.
2001: Mikko Hiltunen; Arto Mannermaa; D Thompson; D Easton; Mia Pirskanen; Seppo Helisalmi; Anne Maria Koivisto; Maarit Lehtovirta; Markku Ryynänen; Hilkka Soininen
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland.
Neurology 2001;57(9):1663-8.
2001: N A Clarke; Hilkka Soininen; L Gustafson; L Minthon; K Alhainen; Paul T Francis
Tacrine may alter APP-like protein levels in the lumbar CSF of Alzheimer patients.
International journal of geriatric psychiatry 2001;16(11):1104-6.
2001: Mikko Hiltunen; Hilkka Soininen
Genes, proteins and brain disease.
Trends in molecular medicine 2001;7(9):382-3.
2001: Bengt Winblad; Knut Engedal; Hilkka Soininen; Frans Verhey; Gunhild Waldemar; Anders Wimo; Anna-Lena Wetterholm; Richard Zhang; Anders Haglund; Ponni Subbiah
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD.
Neurology 2001;57(3):489-95.
2001: Laura Parkkinen; Hilkka Soininen; M Laakso; Irina Alafuzoff
Alpha-synuclein pathology is highly dependent on the case selection.
Neuropathology and applied neurobiology 2001;27(4):314-25.
2001: Mia Pirskanen; Irina Alafuzoff; Mikko Hiltunen; Arto Mannermaa; Seppo Helisalmi; Maarit Lehtovirta; Anne Maria Koivisto; M Laakso; Hilkka Soininen
An association between a subset of Finnish late-onset Alzheimer's disease and alpha2-macroglobulin.
Neurogenetics 2001;3(3):171-2.
2001: Miia Kivipelto; Eeva-Liisa Helkala; Tuomo Hänninen; Mikko P Laakso; Merja Hallikainen; Kari Alhainen; Hilkka Soininen; Jaakko Tuomilehto; Aulikki Nissinen
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study.
Neurology 2001;56(12):1683-9.
2001: Miia Kivipelto; Eeva-Liisa Helkala; Mikko P Laakso; Tuomo Hänninen; Merja Hallikainen; Kari Alhainen; Hilkka Soininen; Jaakko Tuomilehto; Aulikki Nissinen
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
BMJ (Clinical research ed.) 2001;322(7300):1447-51.
2001: Saara Finnilä; Jaana M Autere; M Lehtovirta; Päivi Hartikainen; Arto Mannermaa; Hilkka Soininen; Kari Majamaa
Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNAGln.
Journal of medical genetics 2001;38(6):400-5.
2001: Tero Tapiola; Hilkka Soininen; Tuula Pirttilä
CSF tau and Abeta42 levels in patients with Down's syndrome.
Neurology 2001;56(7):979-80.
2001: Matti Vanhanen; Miia Kivipelto; Keijo Koivisto; Johanna Kuusisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; Kari Kervinen; Y Antero Kesäniemi; Mikko P Laakso; Hilkka Soininen; Markku Laakso
APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.
Neurology 2001;56(5):655-9.
2001: Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.
Biochemical and biophysical research communications 2001;280(4):998-1002.
2001: Michal Kraszpulski; Hilkka Soininen; Seppo Helisalmi; Irina Alafuzoff
The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer's disease.
Acta neurologica Scandinavica 2001;103(2):88-92.
2001: Petri Kerokoski; Hilkka Soininen; Tuula Pirttilä
Beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality.
Neurochemistry international 2001;38(2):127-34.
2001: Mikko P Laakso; Olli Vaurio; E Koivisto; L Savolainen; Markku Eronen; Hannu J Aronen; P Hakola; E Repo; Hilkka Soininen; Jari Tiihonen
Psychopathy and the posterior hippocampus.
Behavioural brain research 2001;118(2):187-93.
2001: Mia Mikkonen; Hilkka Soininen; I Alafuzof; Riitta Miettinen
Hippocampal plasticity in Alzheimer's disease.
Reviews in the neurosciences 2001;12(4):311-25.
2000: M Overmyer; Michal Kraszpulski; Seppo Helisalmi; Hilkka Soininen; Irina Alafuzoff
DNA fragmentation, gliosis and histological hallmarks of Alzheimer's disease.
Acta neuropathologica 2000;100(6):681-7.
2000: W F Reynolds; Mikko Hiltunen; Mia Pirskanen; Arto Mannermaa; Seppo Helisalmi; Maarit Lehtovirta; Irina Alafuzoff; Hilkka Soininen
MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.
Neurology 2000;55(9):1284-90.
2000: Anne Maria Koivisto; P Lempiäinen; Keijo Koivisto; Eeva-Liisa Helkala; Leena Mykkänen; Johanna Kuusisto; Kari Kervinen; Y Antero Kesäniemi; Markku Laakso; Hilkka Soininen
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.
Neuroepidemiology 2000;19(6):327-32.
2000: Tero Tapiola; Tuula Pirttilä; Pankaj D Mehta; I Alafuzofff; Maarit Lehtovirta; Hilkka Soininen
Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease.
Neurobiology of aging 2000;21(5):735-40.
2000: Seppo Helisalmi; RH Valve; Matti K Karvonen; Mikko Hiltunen; Mia Pirskanen; Arto Mannermaa; Markku Koulu; Ullamari Pesonen; Matti Uusitupa; Hilkka Soininen
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
Neuroscience letters 2000;287(1):25-8.
2000: Mikko P Laakso; Giovanni B Frisoni; Mervi Könönen; Mia Mikkonen; Alberto Beltramello; Cristina Geroldi; Angelo Bianchetti; Marco Trabucchi; Hilkka Soininen; Hannu J Aronen
Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study.
Biological psychiatry 2000;47(12):1056-63.
2000: Mikko P Laakso; Olli Vaurio; L Savolainen; E Repo; Hilkka Soininen; Hannu J Aronen; Jari Tiihonen
A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism.
Behavioural brain research 2000;109(2):177-86.
2000: Mikko Hiltunen; Seppo Helisalmi; Arto Mannermaa; Irina Alafuzoff; Anne Maria Koivisto; Maarit Lehtovirta; Mia Pirskanen; Raimo Sulkava; Auli Verkkoniemi; Hilkka Soininen
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?
European journal of human genetics : EJHG 2000;8(4):259-66.
2000: Irina Alafuzoff; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen
Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia.
Annals of the New York Academy of Sciences 2000;903():244-51.
2000: Maija Pihlajamäki; Heikki Tanila; Tuomo Hänninen; Mervi Könönen; M Laakso; Kaarina Partanen; Hilkka Soininen; Hannu J Aronen
Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study.
Annals of neurology 2000;47(4):470-6.
2000: Mikko P Laakso; Maarit Lehtovirta; Kaarina Partanen; PJ Riekkinen; Hilkka Soininen
Hippocampus in Alzheimer's disease: a 3-year follow-up MRI study.
Biological psychiatry 2000;47(6):557-61.
2000: Maarit Lehtovirta; Mikko P Laakso; Giovanni B Frisoni; Hilkka Soininen
How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies.
Neurobiology of aging 2000;21(2):293-300.
2000: Tero Tapiola; Tuula Pirttilä; Mia Mikkonen; Pankaj D Mehta; Irina Alafuzoff; Keijo Koivisto; Hilkka Soininen
Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and 40 concentrations in Alzheimer's disease.
Neuroscience letters 2000;280(2):119-22.
2000: Irina Alafuzoff; Seppo Helisalmi; EH Heinonen; Kari Reinikainen; Merja Hallikainen; Hilkka Soininen; Keijo Koivisto
Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease.
European journal of clinical pharmacology 2000;55(11-12):815-9.
2000: S Savolainen; Mikko P Laakso; Leo Paljärvi; Irina Alafuzoff; Heleena Hurskainen; Kaarina Partanen; Hilkka Soininen; Matti Vapalahti
MR imaging of the hippocampus in normal pressure hydrocephalus: correlations with cortical Alzheimer's disease confirmed by pathologic analysis.
AJNR. American journal of neuroradiology 2000;21(2):409-14.
2000: Seppo Helisalmi; Mikko Hiltunen; Arto Mannermaa; Anne Maria Koivisto; Maarit Lehtovirta; Irina Alafuzoff; Markku Ryynänen; Hilkka Soininen
Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer's disease?
Neuroscience letters 2000;278(1-2):65-8.
2000: K Partanen; M Laakso; Timo Erkinjuntti; Hilkka Soininen
[Imaging diagnostics in early dementia].
Duodecim; lääketieteellinen aikakauskirja 2000;116(10):1049-58.
2000: Hilkka Soininen; R Sulkava
[When should the brain imaging be done in suspected dementia?].
Duodecim; lääketieteellinen aikakauskirja 2000;116(10):1037-8.
2000: Carol Jagger; K Andersen; Monique Breteler; John R M Copeland; Catherine Helmer; M Baldereschi; Laura Fratiglioni; Antonio Lobo; Hilkka Soininen; Albert Hofman; Lenore J Launer
Prognosis with dementia in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Neurology 2000;54(11 Suppl 5):S16-20.
2000: Laura Fratiglioni; Lenore J Launer; K Andersen; Monique Breteler; John R M Copeland; Jean-François Dartigues; Antonio Lobo; JM Martinez-Lage; Hilkka Soininen; Albert Hofman
Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Neurology 2000;54(11 Suppl 5):S10-5.
2000: Antonio Lobo; Lenore J Launer; Laura Fratiglioni; K Andersen; A Di Carlo; Monique Breteler; John R M Copeland; Jean-François Dartigues; Carol Jagger; JM Martinez-Lage; Hilkka Soininen; Albert Hofman
Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Neurology 2000;54(11 Suppl 5):S4-9.
2000: Mia Mikkonen; Asla Pitkänen; Hilkka Soininen; Irina Alafuzoff; Riitta Miettinen
Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow.
Neuroscience 2000;96(3):515-22.
2000: Mikko P Laakso; Merja Hallikainen; Tuomo Hänninen; Kaarina Partanen; Hilkka Soininen
Diagnosis of Alzheimer's disease: MRI of the hippocampus vs delayed recall.
Neuropsychologia 2000;38(5):579-84.
2000: Maarit Lehtovirta; J Partanen; Mervi Könönen; Jukka Hiltunen; Seppo Helisalmi; Päivi Hartikainen; PJ Riekkinen; Hilkka Soininen
A longitudinal quantitative EEG study of Alzheimer's disease: relation to apolipoprotein E polymorphism.
Dementia and geriatric cognitive disorders 2000;11(1):29-35.
2000: Cristina Geroldi; Mikko P Laakso; Charles DeCarli; Alberto Beltramello; Angelo Bianchetti; Hilkka Soininen; Marco Trabucchi; Giovanni B Frisoni
Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study.
Journal of neurology, neurosurgery, and psychiatry 2000;68(1):93-6.
1999: Cristina Geroldi; Maija Pihlajamäki; Mikko P Laakso; Charles DeCarli; Alberto Beltramello; Angelo Bianchetti; Hilkka Soininen; Marco Trabucchi; Giovanni B Frisoni
APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD.
Neurology 1999;53(8):1825-32.
1999: Seppo Helisalmi; Mikko Hiltunen; Piia Valonen; Arto Mannermaa; Anne Maria Koivisto; Maarit Lehtovirta; Markku Ryynänen; Hilkka Soininen
Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.
Journal of neurology 1999;246(9):821-4.
1999: Mikko Hiltunen; Arto Mannermaa; Anne Maria Koivisto; Maarit Lehtovirta; Seppo Helisalmi; Markku Ryynänen; PJ Riekkinen; Hilkka Soininen
Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients.
European journal of human genetics : EJHG 1999;7(6):652-8.
1999: Matti Vanhanen; J Kuusisto; Keijo Koivisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; PJ Riekkinen; Hilkka Soininen; M Laakso
Type-2 diabetes and cognitive function in a non-demented population.
Acta neurologica Scandinavica 1999;100(2):97-101.
1999: M Overmyer; Seppo Helisalmi; Hilkka Soininen; Markku Laakso; PJ Riekkinen; Irina Alafuzoff
Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue.
Dementia and geriatric cognitive disorders 1999;10(4):252-7.
1999: Irina Alafuzoff; Päivi Hartikainen; T Hanninen; Kaarina Partanen; Jyrki Kuikka; K Syrjänen; Anita Naukkarinen; Hilkka Soininen
Rapidly progressive multifocal leukoencephalopathy with substantial cell-mediated inflammatory response and with cognitive decline of non-Alzheimer type in a 75-year-old female patient.
Clinical neuropathology 1999;18(3):113-23.
1999: Mia Mikkonen; Hilkka Soininen; Tero Tapiola; Irina Alafuzoff; Riitta Miettinen
Hippocampal plasticity in Alzheimer's disease: changes in highly polysialylated NCAM immunoreactivity in the hippocampal formation.
The European journal of neuroscience 1999;11(5):1754-64.
1999: M Overmyer; Seppo Helisalmi; Hilkka Soininen; Markku Laakso; PJ Riekkinen; Irina Alafuzoff
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.
Acta neuropathologica 1999;97(4):383-92.
1999: T Hänninen; Hilkka Soininen
[Mild cognitive impairment as an early sign of dementia].
Duodecim; lääketieteellinen aikakauskirja 1999;115(4):381-8.
1999: J Turunen; Pekka Loula; Hilkka Soininen
Automatization of physicians' phone-in hours.
Studies in health technology and informatics 1999;68():621-4.
1999: Mia Mikkonen; Irina Alafuzoff; Tero Tapiola; Hilkka Soininen; Riitta Miettinen
Subfield- and layer-specific changes in parvalbumin, calretinin and calbindin-D28K immunoreactivity in the entorhinal cortex in Alzheimer's disease.
Neuroscience 1999;92(2):515-32.
1999: K Juottonen; Mikko P Laakso; Kaarina Partanen; Hilkka Soininen
Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease.
AJNR. American journal of neuroradiology 1999;20(1):139-44.
1999: Giovanni B Frisoni; Mikko P Laakso; Alberto Beltramello; Cristina Geroldi; Angelo Bianchetti; Hilkka Soininen; Marco Trabucchi
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease.
Neurology 1999;52(1):91-100.
1998: Hilkka Soininen; Philip scheltens
Early diagnostic indices for the prevention of Alzheimer's disease.
Annals of medicine 1998;30(6):553-9.
1998: M Vanhanen; Hilkka Soininen
Glucose intolerance, cognitive impairment and Alzheimer's disease.
Current opinion in neurology 1998;11(6):673-7.
1998: Mia Mikkonen; Hilkka Soininen; R Kälviänen; Tero Tapiola; Aarne Ylinen; Matti Vapalahti; Leo Paljärvi; Asla Pitkänen
Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex.
Annals of neurology 1998;44(6):923-34.
1998: Michal Kraszpulski; Hilkka Soininen; PJ Riekkinen; Irina Alafuzoff
Pitfalls in the quantitative estimation of beta-amyloid immunoreactivity in human brain tissue.
Histochemistry and cell biology 1998;110(4):439-45.
1998: K Juottonen; Maarit Lehtovirta; Seppo Helisalmi; PJ Riekkinen; Hilkka Soininen
Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.
Journal of neurology, neurosurgery, and psychiatry 1998;65(3):322-7.
1998: Tero Tapiola; M Lehtovirta; T Pirttilä; Irina Alafuzoff; PJ Riekkinen; Hilkka Soininen
Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer's disease.
Lancet 1998;352(9124):287.
1998: Mikko Hiltunen; Arto Mannermaa; Seppo Helisalmi; Anne Maria Koivisto; Maarit Lehtovirta; Markku Ryynänen; PJ Riekkinen; Hilkka Soininen
Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients.
Neuroscience letters 1998;250(1):69-71.
1998: Tuula Pirttilä; Keijo Koivisto; Pankaj D Mehta; Kari Reinikainen; K S Kim; O Kilkku; EH Heinonen; Hilkka Soininen; PJ Riekkinen; Henryk M Wisniewski
Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease.
Neuroscience letters 1998;249(1):21-4.
1998: Maarit Lehtovirta; Jyrki Kuikka; Seppo Helisalmi; Päivi Hartikainen; Arto Mannermaa; Markku Ryynänen; Hilkka Soininen
Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism.
Journal of neurology, neurosurgery, and psychiatry 1998;64(6):742-6.
1998: PJ Riekkinen; K Kejonen; Mikko P Laakso; Hilkka Soininen; Kaarina Partanen; Mervi S Riekkinen
Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson's disease patients.
Neuroreport 1998;9(7):1507-11.
1998: Mervi S Riekkinen; K Kejonen; Pekka Jäkälä; Hilkka Soininen; PJ Riekkinen
Reduction of noradrenaline impairs attention and dopamine depletion slows responses in Parkinson's disease.
The European journal of neuroscience 1998;10(4):1429-35.
1998: Ricardo Insausti; K Juottonen; Hilkka Soininen; AM Insausti; Kaarina Partanen; Pauli Vainio; Mikko P Laakso; Asla Pitkänen
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices.
AJNR. American journal of neuroradiology 1998;19(4):659-71.
1998: Matti Vanhanen; Keijo Koivisto; Johanna Kuusisto; Leena Mykkänen; Eeva-Liisa Helkala; Tuomo Hänninen; PJ Riekkinen; Hilkka Soininen; Markku Laakso
Cognitive function in an elderly population with persistent impaired glucose tolerance.
Diabetes care 1998;21(3):398-402.
1998: Mervi S Riekkinen; Hilkka Soininen; PJ Riekkinen; J Kuikka; Markku Laakso; Eeva-Liisa Helkala; J Partanen; P Riekkinen
Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease.
Neuroscience 1998;83(2):471-9.
1998: H Sorvari; Riitta Miettinen; Hilkka Soininen; Leo Paljärvi; Kari Karkola; Asla Pitkänen
Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala.
Brain research 1998;783(2):355-8.
1998: Mikko P Laakso; Hilkka Soininen; Kaarina Partanen; Maarit Lehtovirta; Merja Hallikainen; Tuomo Hänninen; Eeva-Liisa Helkala; Pauli Vainio; PJ Riekkinen
MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity, and analysis of the incorrectly classified subjects.
Neurobiology of aging 1998;19(1):23-31.
1998: K Juottonen; Mikko P Laakso; Ricardo Insausti; Maarit Lehtovirta; Asla Pitkänen; Kaarina Partanen; Hilkka Soininen
Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease.
Neurobiology of aging 1998;19(1):15-22.
1998: Tero Tapiola; Maarit Lehtovirta; J Ramberg; Seppo Helisalmi; K Linnaranta; PJ Riekkinen; Hilkka Soininen
CSF tau is related to apolipoprotein E genotype in early Alzheimer's disease.
Neurology 1998;50(1):169-74.
1997: Tero Tapiola; M Overmyer; Maarit Lehtovirta; Seppo Helisalmi; J Ramberg; Irina Alafuzoff; PJ Riekkinen; Hilkka Soininen
The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease.
Neuroreport 1997;8(18):3961-3.
1997: Pauliina Korhonen; V Huotari; Hilkka Soininen; Antero Salminen
Glutamate-induced changes in the DNA-binding complexes of transcription factor YY1 in cultured hippocampal and cerebellar granule cells.
Brain research. Molecular brain research 1997;52(2):330-3.
1997: Tuomo Hänninen; Hilkka Soininen
Age-associated memory impairment. Normal aging or warning of dementia?
Drugs & aging 1997;11(6):480-9.
1997: Mia Mikkonen; Hilkka Soininen; Asla Pitkänen
Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex.
The Journal of comparative neurology 1997;388(1):64-88.
1997: Antero Salminen; Markku Helenius; Tapani Lahtinen; Pauliina Korhonen; Tero Tapiola; Hilkka Soininen; Victor T Solovyan
Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence.
Biochemical and biophysical research communications 1997;238(3):712-6.
1997: PJ Riekkinen; Ari Pääkkönen; Jari Karhu; J Partanen; Hilkka Soininen; Markku Laakso; P Riekkine
THA disrupts mismatch negativity in Alzheimer disease.
Psychopharmacology 1997;133(2):203-6.
1997: Seppo Helisalmi; Arto Mannermaa; Maarit Lehtovirta; Markku Ryynänen; PJ Riekkinen; Hilkka Soininen
No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease.
Neuroscience letters 1997;231(1):56-8.
1997: Pekka Jäkälä; Tuomo Hänninen; Markku Ryynänen; Markku Laakso; Kaarina Partanen; Arto Mannermaa; Hilkka Soininen
Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.
The Journal of clinical investigation 1997;100(2):331-8.
1997: PJ Riekkinen; Mervi S Riekkinen; Hilkka Soininen; J Kuikka; Markku Laakso; P Riekkinen
Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease.
Neuroreport 1997;8(8):1845-9.
1997: Matti Vanhanen; Keijo Koivisto; L Karjalainen; Eeva-Liisa Helkala; Markku Laakso; Hilkka Soininen; PJ Riekkinen
Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function.
Neuroreport 1997;8(6):1527-30.
1997: PJ Riekkinen; Hilkka Soininen; J Partanen; Ari Pääkkönen; S Helisalmi; P Riekkinen
The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients.
Psychopharmacology 1997;129(3):285-8.
1997: Hilkka Soininen
[Treatment of Alzheimer's disease].
Duodecim; lääketieteellinen aikakauskirja 1997;113(18):1739-46.
1997: Juhani Partanen; Hilkka Soininen; Eeva-Liisa Helkala; Mervi Könönen; R Kilpeläinen; PJ Riekkinen
Relationship between EEG reactivity and neuropsychological tests in vascular dementia.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(8-9):905-12.
1997: M P Laakso; K Juottonen; K Partanen; Pauli Vainio; Hilkka Soininen
MRI volumetry of the hippocampus: the effect of slice thickness on volume formation.
Magnetic resonance imaging 1997;15(2):263-5.
1997: Tuomo Hänninen; Merja Hallikainen; Keijo Koivisto; Kaarina Partanen; Mikko P Laakso; PJ Riekkinen; Hilkka Soininen
Decline of frontal lobe functions in subjects with age-associated memory impairment.
Neurology 1997;48(1):148-53.
1997: Tuula Pirttilä; Hilkka Soininen; Pankaj D Mehta; Outi Kopra; T Lehtimäki; Nenad Bogdanovic; L Paljärvi; K S Kim; O Kosunen; Bengt Winblad; PJ Riekkinen; Henryk M Wisniewski
Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains.
Neurobiology of aging 1997;18(1):121-7.
1996: Eeva-Liisa Helkala; Tuomo Hänninen; Merja Hallikainen; M Könönen; Mikko P Laakso; Päivi Hartikainen; Hilkka Soininen; Juhani Partanen; K Partanen; P Vainio; PJ Riekkinen
Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer's disease patients.
Behavioral neuroscience 1996;110(6):1235-43.
1996: H Sorvari; Hilkka Soininen; Asla Pitkänen
Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex.
Neuroscience 1996;75(2):421-43.
1996: H Sorvari; Riitta Miettinen; Hilkka Soininen; Asla Pitkänen
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study.
Neuroscience letters 1996;217(2-3):93-6.
1996: Juhani Partanen; Hilkka Soininen; M Könönen; R Kilpeläinen; E L Helkala; PJ Riekkinen
EEG reactivity correlates with neuropsychological test scores in Down's syndrome.
Acta neurologica Scandinavica 1996;94(4):242-6.
1996: Mikko P Laakso; Kaarina Partanen; Hilkka Soininen; Maarit Lehtovirta; Merja Hallikainen; Tuomo Hänninen; Eeva-Liisa Helkala; Pauli Vainio; PJ Riekkinen
MR T2 relaxometry in Alzheimer's disease and age-associated memory impairment.
Neurobiology of aging 1996;17(4):535-40.
1996: Maarit Lehtovirta; J Partanen; M Könönen; Hilkka Soininen; Seppo Helisalmi; Arto Mannermaa; Markku Ryynänen; Päivi Hartikainen; PJ Riekkinen
Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism.
Neurobiology of aging 1996;17(4):523-6.
1996: Hilkka Soininen; PJ Riekkinen
Apolipoprotein E, memory and Alzheimer's disease.
Trends in neurosciences 1996;19(6):224-8.
1996: A Pitkänen; M Laakso; Reetta Kälviäinen; K Partanen; P Vainio; M Lehtovirta; PJ Riekkinen; Hilkka Soininen
Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease.
Neurology 1996;46(6):1724-30.
1996: Maarit Lehtovirta; Hilkka Soininen; Mikko P Laakso; Kaarina Partanen; Seppo Helisalmi; Arto Mannermaa; Markku Ryynänen; Jyrki Kuikka; Päivi Hartikainen; PJ Riekkinen
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele.
Journal of neurology, neurosurgery, and psychiatry 1996;60(6):644-9.
1996: H Sorvari; Hilkka Soininen; Asla Pitkänen
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex.
The Journal of comparative neurology 1996;369(2):188-208.
1996: Tuula Pirttilä; Hilkka Soininen; Outi Kopra; T Lehtimäki; Nenad Bogdanovic; Leo Paljärvi; O Kosunen; Bengt Winblad; PJ Riekkinen; Henryk M Wisniewski; Pankaj D Mehta
Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls.
Brain research 1996;722(1-2):71-7.
1996: T Hanninen; Keijo Koivisto; K J Reinikainen; Eeva-Liisa Helkala; Hilkka Soininen; L Mykkänen; Markku Laakso; PJ Riekkinen
Prevalence of ageing-associated cognitive decline in an elderly population.
Age and ageing 1996;25(3):201-5.
1996: Mikko P Laakso; Kaarina Partanen; PJ Riekkinen; Maarit Lehtovirta; Eeva-Liisa Helkala; Merja Hallikainen; T Hanninen; Pauli Vainio; Hilkka Soininen
Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study.
Neurology 1996;46(3):678-81.
1996: Seppo Helisalmi; Arto Mannermaa; Maarit Lehtovirta; Markku Ryynänen; PJ Riekkinen; Hilkka Soininen
Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease.
Neuroscience letters 1996;205(1):68-70.
1996: Seppo Helisalmi; K Linnaranta; Maarit Lehtovirta; Arto Mannermaa; Outi Kopra; Markku Ryynänen; PJ Riekkinen; Hilkka Soininen
Apolipoprotein E polymorphism in patients with different neurodegenerative disorders.
Neuroscience letters 1996;205(1):61-4.
1996: Tuula Pirttilä; Pankaj D Mehta; Hilkka Soininen; K S Kim; Outi Kopra; Leo Paljärvi; O Kosunen; PJ Riekkinen; Henryk M Wisniewski
Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: correlations with amyloid load in the brain.
Archives of neurology 1996;53(2):189-93.
1996: Maarit Lehtovirta; Hilkka Soininen; Seppo Helisalmi; Arto Mannermaa; Eeva-Liisa Helkala; Päivi Hartikainen; Tuomo Hänninen; Markku Ryynänen; PJ Riekkinen
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.
Neurology 1996;46(2):413-9.
1996: O Kosunen; Hilkka Soininen; Leo Paljärvi; Outi Kopra; S Talasniemi; PJ Riekkinen
Diagnostic accuracy of Alzheimer's disease: a neuropathological study.
Acta neuropathologica 1996;91(2):185-93.
1995: Hilkka Soininen; Maarit Lehtovirta; Seppo Helisalmi; K Linnaranta; Outi Kopra; PJ Riekkinen
Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele.
Neuroreport 1995;6(18):2518-20.
1995: Mikko P Laakso; Kaarina Partanen; Maarit Lehtovirta; Merja Hallikainen; Tuomo Hänninen; Pauli Vainio; PJ Riekkinen; Hilkka Soininen
MRI of amygdala fails to diagnose early Alzheimer's disease.
Neuroreport 1995;6(17):2414-8.
1995: H Sorvari; Hilkka Soininen; Leo Paljärvi; Kari Karkola; Asla Pitkänen
Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex.
The Journal of comparative neurology 1995;360(2):185-212.
1995: Tuomo Hänninen; Merja Hallikainen; Keijo Koivisto; Eeva-Liisa Helkala; K J Reinikainen; Hilkka Soininen; L Mykkänen; Markku Laakso; Kalevi Pyörälä; PJ Riekkinen
A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia.
Journal of the American Geriatrics Society 1995;43(9):1007-15.
1995: PJ Riekkinen; Jyrki Kuikka; Hilkka Soininen; Eeva-Liisa Helkala; Merja Hallikainen; P Riekkinen
Tetrahydroaminoacridine modulates technetium-99m labelled ethylene dicysteinate retention in Alzheimer's disease measured with single photon emission computed tomography imaging.
Neuroscience letters 1995;195(1):53-6.
1995: Outi Kopra; Maarit Lehtovirta; Hilkka Soininen; Seppo Helisalmi; Arto Mannermaa; H Sorvari; O Kosunen; Leo Paljärvi; Markku Ryynänen; PJ Riekkinen
Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.
Neurobiology of aging 1995;16(4):505-13.
1995: Maarit Lehtovirta; Mikko P Laakso; Hilkka Soininen; Seppo Helisalmi; Arto Mannermaa; Eeva-Liisa Helkala; Kaarina Partanen; Markku Ryynänen; Pauli Vainio; Päivi Hartikainen
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes.
Neuroscience 1995;67(1):65-72.
1995: PJ Riekkinen; Hilkka Soininen; Eeva-Liisa Helkala; Kaarina Partanen; Markku Laakso; Matti Vanhanen; P Riekkinen
Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease.
Neuroreport 1995;6(9):1297-300.
1995: O Kosunen; S Talasniemi; Maarit Lehtovirta; Outi Kopra; Seppo Helisalmi; Arto Mannermaa; Leo Paljärvi; Markku Ryynänen; PJ Riekkinen; Hilkka Soininen
Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients.
Stroke; a journal of cerebral circulation 1995;26(5):743-8.
1995: Hilkka Soininen; Jari Karhu; Juhani Partanen; Ari Pääkkönen; V Jousmäki; Tuomo Hänninen; Merja Hallikainen; Kaarina Partanen; Mikko P Laakso; Keijo Koivisto
Habituation of auditory N100 correlates with amygdaloid volumes and frontal functions in age-associated memory impairment.
Physiology & behavior 1995;57(5):927-35.
1995: Markku Laakso; Hilkka Soininen; Kaarina Partanen; Merja Hallikainen; Maarit Lehtovirta; Tuomo Hänninen; Pauli Vainio; PJ Riekkinen
The interuncal distance in Alzheimer disease and age-associated memory impairment.
AJNR. American journal of neuroradiology 1995;16(4):727-34.
1995: Hilkka Soininen; O Kosunen; Seppo Helisalmi; Arto Mannermaa; Leo Paljärvi; S Talasniemi; Markku Ryynänen; PJ Riekkinen
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele.
Neuroscience letters 1995;187(2):79-82.
1995: Maarit Lehtovirta; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen; Keijo Koivisto; Markku Ryynänen; PJ Riekkinen
Apolipoprotein E polymorphism and Alzheimer's disease in eastern Finland.
Neuroscience letters 1995;185(1):13-5.
1995: Hilkka Soininen; Kaarina Partanen; Asla Pitkänen; Merja Hallikainen; Tuomo Hänninen; Seppo Helisalmi; Arto Mannermaa; Markku Ryynänen; Keijo Koivisto; PJ Riekkinen
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele.
Neurology 1995;45(2):391-2.
1995: Hilkka Soininen; Eeva-Liisa Helkala; Jyrki Kuikka; Päivi Hartikainen; Maarit Lehtovirta; PJ Riekkinen
Regional cerebral blood flow measured by 99mTc-HMPAO SPECT differs in subgroups of Alzheimer's disease.
Journal of neural transmission. Parkinson's disease and dementia section 1995;9(2-3):95-109.
1995: Outi Kopra; Hilkka Soininen; H Sorvari; O Kosunen; Leo Paljärvi; Esa H Koivisto; PJ Riekkinen
Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease.
Neuroscience 1995;64(2):375-84.
1995: Mikko P Laakso; Hilkka Soininen; Kaarina Partanen; Eeva-Liisa Helkala; Päivi Hartikainen; Pauli Vainio; Merja Hallikainen; Tuomo Hänninen; PJ Riekkinen
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions.
Journal of neural transmission. Parkinson's disease and dementia section 1995;9(1):73-86.
1994: Hilkka Soininen; Kaarina Partanen; Asla Pitkänen; Pauli Vainio; Tuomo Hänninen; Merja Hallikainen; Keijo Koivisto; PJ Riekkinen
Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory.
Neurology 1994;44(9):1660-8.
1994: Outi Kopra; Hilkka Soininen; Stina Syrjänen; H Neittaanmäki; Leo Paljärvi; O Kosunen; Kari Syrjänen; PJ Riekkinen
beta-Amyloid protein immunoreactivity in skin is not a reliable marker of Alzheimer's disease. An autopsy-controlled study.
Archives of neurology 1994;51(8):799-804.
1994: Juhani Partanen; Päivi Hartikainen; M Könönen; V Jousmäki; Hilkka Soininen; PJ Riekkinen
Prolonged latencies of pattern reversal visual evoked early potentials in Alzheimer disease.
Alzheimer disease and associated disorders 1994;8(4):250-8.
1994: Outi Kopra; K Kurvinen; Hilkka Soininen; H Koponen; Stina Syrjänen; PJ Riekkinen
Testing for mutations in exon 17 of the beta-amyloid precursor protein gene in Finnish Alzheimer patients and normal subjects.
Journal of neural transmission. Parkinson's disease and dementia section 1994;7(3):211-5.
1993: V Laulumaa; Jyrki T Kuikka; Hilkka Soininen; Kim A Bergström; E Länsimies; PJ Riekkinen
Imaging of D2 dopamine receptors of patients with Parkinson's disease using single photon emission computed tomography and iodobenzamide I 123.
Archives of neurology 1993;50(5):509-12.
1993: Hilkka Soininen; Juhani Partanen; V Jousmäki; Eeva-Liisa Helkala; Matti Vanhanen; S Majuri; M Kaski; Päivi Hartikainen; PJ Riekkinen
Age-related cognitive decline and electroencephalogram slowing in Down's syndrome as a model of Alzheimer's disease.
Neuroscience 1993;53(1):57-63.
1993: Outi Kopra; Stina Syrjänen; Hilkka Soininen; S Talasniemi; M Kaski; R Mäntyjärvi; Kari Syrjänen; PJ Riekkinen
Circulating immune complexes in sera from patients with Alzheimer's disease, multi-infarct dementia and Down's syndrome.
Neuroscience letters 1993;149(1):67-70.
1993: Hilkka Soininen; K J Reinikainen; Matti Puranen; Eeva-Liisa Helkala; Leo Paljärvi; PJ Riekkinen
Wide third ventricle correlates with low choline acetyltransferase activity of the neocortex in Alzheimer patients.
Alzheimer disease and associated disorders 1993;7(1):39-47.
1993: Hilkka Soininen; Outi Kopra; Merja Hallikainen; Tuomo Hänninen; Keijo Koivisto; Stina Syrjänen; S Talasniemi; PJ Riekkinen
Circulating immune complexes in sera from patients with Alzheimer's disease and subjects with age-associated memory impairment.
Journal of neural transmission. Parkinson's disease and dementia section 1993;6(3):179-88.
1993: Päivi Hartikainen; Eeva-Liisa Helkala; Hilkka Soininen; PJ Riekkinen
Cognitive and memory deficits in untreated Parkinson's disease and amyotrophic lateral sclerosis patients: a comparative study.
Journal of neural transmission. Parkinson's disease and dementia section 1993;6(2):127-37.
1993: Hilkka Soininen; PJ Riekkinen
[Regulation of attention].
Duodecim; lääketieteellinen aikakauskirja 1993;109(21):2001-6.
1992: Hilkka Soininen; Matti Puranen; Eeva-Liisa Helkala; M Laakso; PJ Riekkinen
Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population.
Neurobiology of aging 1992;13(6):717-21.
1992: Hilkka Soininen; K J Reinikainen; Juhani Partanen; Eeva-Liisa Helkala; Leo Paljärvi; PJ Riekkinen
Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer's disease.
Neuroscience 1992;49(3):529-35.
1992: Päivi Hartikainen; Hilkka Soininen; Juhani Partanen; Eeva-Liisa Helkala; PJ Riekkinen
Aging and spectral analysis of EEG in normal subjects: a link to memory and CSF AChE.
Acta neurologica Scandinavica 1992;86(2):148-55.
1992: Hilkka Soininen; K Reinikainen; Juhani Partanen; E Mervaala; Leo Paljärvi; Eeva-Liisa Helkala; PJ Riekkinen
Slowing of the dominant occipital rhythm in electroencephalogram is associated with low concentration of noradrenaline in the thalamus in patients with Alzheimer's disease.
Neuroscience letters 1992;137(1):5-8.
1992: Hilkka Soininen; Stina Syrjänen; Outi Kopra; H Neittaanmäki; Riitta Miettinen; Leo Paljärvi; Kari Syrjänen; Konrad Beyreuther; PJ Riekkinen
Amyloid beta-protein deposition in skin of patients with dementia.
Lancet 1992;339(8787):245.
1992: Hilkka Soininen; Eeva-Liisa Helkala; V Laulumaa; R Soikkeli; Päivi Hartikainen; PJ Riekkinen
Cognitive profile of Alzheimer patients with extrapyramidal signs: a longitudinal study.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(3):241-54.
1992: Hilkka Soininen; PJ Riekkinen
EEG in diagnostics and follow-up of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1992;139():36-9.
1992: Hilkka Soininen; V Laulumaa; Eeva-Liisa Helkala; Päivi Hartikainen; PJ Riekkinen
Extrapyramidal signs in Alzheimer's disease: a 3-year follow-up study.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(2):107-19.
1992: Päivi Hartikainen; K J Reinikainen; Hilkka Soininen; Jouni Sirviö; R Soikkeli; PJ Riekkinen
Neurochemical markers in the cerebrospinal fluid of patients with Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and normal controls.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(1):53-68.
1991: Hilkka Soininen; Juhani Partanen; V Laulumaa; Ari Pääkkönen; Eeva-Liisa Helkala; PJ Riekkinen
Serial EEG in Alzheimer's disease: 3 year follow-up and clinical outcome.
Electroencephalography and clinical neurophysiology 1991;79(5):342-8.
1991: R Soikkeli; J Partanen; Hilkka Soininen; A Pääkkönen; PJ Riekkinen
Slowing of EEG in Parkinson's disease.
Electroencephalography and clinical neurophysiology 1991;79(3):159-65.
1991: K Alhainen; Juhani Partanen; K Reinikainen; V Laulumaa; Hilkka Soininen; M Airaksinen; PJ Riekkinen
Discrimination of tetrahydroaminoacridine responders by a single dose pharmaco-EEG in patients with Alzheimer's disease.
Neuroscience letters 1991;127(1):113-6.
1991: Eeva-Liisa Helkala; V Laulumaa; R Soikkeli; Juhani Partanen; Hilkka Soininen; PJ Riekkinen
Slow-wave activity in the spectral analysis of the electroencephalogram is associated with cortical dysfunctions in patients with Alzheimer's disease.
Behavioral neuroscience 1991;105(3):409-15.
1991: Eeva-Liisa Helkala; V Laulumaa; Hilkka Soininen; Juhani Partanen; PJ Riekkinen
Different patterns of cognitive decline related to normal or deteriorating EEG in a 3-year follow-up study of patients with Alzheimer's disease.
Neurology 1991;41(4):528-32.
1991: U Nousiainen; Juhani Partanen; K Koivisto; Hilkka Soininen; PJ Riekkinen
Electroneuromyographic findings in patients with Alzheimer's disease.
Electromyography and clinical neurophysiology 1991;31(2):119-22.
1991: Hilkka Soininen; Juhani Partanen; Ari Pääkkönen; Esa H Koivisto; PJ Riekkinen
Changes in absolute power values of EEG spectra in the follow-up of Alzheimer's disease.
Acta neurologica Scandinavica 1991;83(2):133-6.
1991: PJ Riekkinen; Gyorgy Buzsaki; P Riekkinen; Hilkka Soininen; Juhani Partanen
The cholinergic system and EEG slow waves.
Electroencephalography and clinical neurophysiology 1991;78(2):89-96.
1991: C.M. Duijn; D Clayton; V Chandra; Laura Fratiglioni; Amy Borenstein Graves; A Heyman; Anthony Jorm; Emre Kokmen; K Kondo; J A Mortimer; W A Rocca; S L Shalat; Hilkka Soininen; Albert Hofman
Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies.
International journal of epidemiology 1991;20 Suppl 2():S13-20.
1991: Päivi Hartikainen; Hilkka Soininen; K J Reinikainen; Jouni Sirviö; R Soikkeli; PJ Riekkinen
Neurotransmitter markers in the cerebrospinal fluid of normal subjects. Effects of aging and other confounding factors.
Journal of neural transmission. General section 1991;84(1-2):103-17.
1990: K J Reinikainen; Hilkka Soininen; PJ Riekkinen
Neurotransmitter changes in Alzheimer's disease: implications to diagnostics and therapy.
Journal of neuroscience research 1990;27(4):576-86.
1990: Hilkka Soininen; L Unni; Sam Shillcutt
Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain.
Neurochemical research 1990;15(12):1185-90.
1990: Hilkka Soininen
[Examination of a patient with dementia].
Duodecim; lääketieteellinen aikakauskirja 1990;106(12):947-54.
1989: Hannu Koponen; U Stenbäck; E Mattila; K Reinikainen; Hilkka Soininen; PJ Riekkinen
Cerebrospinal fluid somatostatin in delirium.
Psychological medicine 1989;19(3):605-9.
1989: Hannu Koponen; U Stenbäck; E Mattila; Hilkka Soininen; K Reinikainen; PJ Riekkinen
Delirium among elderly persons admitted to a psychiatric hospital: clinical course during the acute stage and one-year follow-up.
Acta psychiatrica Scandinavica 1989;79(6):579-85.
1989: Hannu Koponen; L Hurri; U Stenbäck; E Mattila; Hilkka Soininen; PJ Riekkinen
Computed tomography findings in delirium.
The Journal of nervous and mental disease 1989;177(4):226-31.
1989: Hannu Koponen; U Stenbäck; E Mattila; K Reinikainen; Hilkka Soininen; PJ Riekkinen
CSF beta-endorphin-like immunoreactivity in delirium.
Biological psychiatry 1989;25(7):938-44.
1989: Hilkka Soininen; Juhani Partanen; V Laulumaa; Eeva-Liisa Helkala; M Laakso; PJ Riekkinen
Longitudinal EEG spectral analysis in early stage of Alzheimer's disease.
Electroencephalography and clinical neurophysiology 1989;72(4):290-7.
1989: Jouni Sirviö; R Kutvonen; Hilkka Soininen; Päivi Hartikainen; PJ Riekkinen
Cholinesterases in the cerebrospinal fluid, plasma, and erythrocytes of patients with Alzheimer's disease.
Journal of neural transmission 1989;75(2):119-27.
1989: Eeva-Liisa Helkala; V Laulumaa; Hilkka Soininen; PJ Riekkinen
Different error pattern of episodic and semantic memory in Alzheimer's disease and Parkinson's disease with dementia.
Neuropsychologia 1989;27(10):1241-8.
1988: Eeva-Liisa Helkala; V Laulumaa; Hilkka Soininen; PJ Riekkinen
Recall and recognition memory in patients with Alzheimer's and Parkinson's diseases.
Annals of neurology 1988;24(2):214-7.
1988: K J Reinikainen; Leo Paljärvi; M Huuskonen; Hilkka Soininen; Markku Laakso; PJ Riekkinen
A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease.
Journal of the neurological sciences 1988;84(1):101-16.
1988: Hilkka Soininen; PJ Riekkinen; Juhani Partanen; Eeva-Liisa Helkala; V Laulumaa; Jukka Jolkkonen; K Reinikainen
Cerebrospinal fluid somatostatin correlates with spectral EEG variables and with parietotemporal cognitive dysfunction in Alzheimer patients.
Neuroscience letters 1988;85(1):131-6.
1988: K J Reinikainen; PJ Riekkinen; Leo Paljärvi; Hilkka Soininen; Eeva-Liisa Helkala; Jukka Jolkkonen; Markku Laakso
Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data.
Neurochemical research 1988;13(2):135-46.
1987: Jouni Sirviö; Hilkka Soininen; R Kutvonen; Juha Hyttinen; Eeva-Liisa Helkala; PJ Riekkinen
Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease.
Journal of the neurological sciences 1987;81(2-3):273-9.
1987: J Jolkkonen; M Lehtinen; Hilkka Soininen; C Sennef; PJ Riekkinen
Enhanced monoaminergic neurotransmission by desglycinamide-arginine-vasopressin in human subjects.
Neuroscience letters 1987;76(3):312-5.
1987: PJ Riekkinen; J J Legros; C Sennef; J Jolkkonen; S Smitz; Hilkka Soininen
Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects.
Peptides 1987;8(2):261-5.
1987: Jukka Jolkkonen; Hilkka Soininen; PJ Riekkinen
beta-Endorphin-like immunoreactivity in cerebrospinal fluid of patients with Alzheimer's disease and Parkinson's disease.
Journal of the neurological sciences 1987;77(2-3):153-9.
1987: K J Reinikainen; PJ Riekkinen; Jukka Jolkkonen; V M Kosma; Hilkka Soininen
Decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in Alzheimer's disease.
Brain research 1987;402(1):103-8.
1987: PJ Riekkinen; Hilkka Soininen; Jouni Sirviö; K Reinikainen; Eeva-Liisa Helkala; Leo Paljärvi
Dementia without cholinergic deficit.
Gerontology 1987;33(3-4):268-72.
1987: PJ Riekkinen; V Laulumaa; J Sirviö; Hilkka Soininen; Eeva-Liisa Helkala
Recent progress in the research of Alzheimer's disease.
Medical biology 1987;65(2-3):83-8.
1986: Jukka Jolkkonen; Hilkka Soininen; Toivo Halonen; Aarne Ylinen; V Laulumaa; M Laakso; PJ Riekkinen
Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia.
Journal of neurology, neurosurgery, and psychiatry 1986;49(12):1374-7.
1986: J V Partanen; Hilkka Soininen; PJ Riekkinen
Does an ACTH derivative (Org 2766) prevent deterioration of EEG in Alzheimer's disease?
Electroencephalography and clinical neurophysiology 1986;63(6):547-51.
1985: Hilkka Soininen; T Koskinen; E L Helkala; R Pigache; PJ Riekkinen
Treatment of Alzheimer's disease with a synthetic ACTH 4-9 analog.
Neurology 1985;35(9):1348-51.
1985: Jukka Jolkkonen; Hilkka Soininen; PJ Riekkinen
The effect of ACTH4-9 analog (Org2766) on some cerebrospinal fluid parameters in patients with Alzheimer's disease.
Life sciences 1985;37(7):585-90.
1985: M Penttilä; J V Partanen; Hilkka Soininen; PJ Riekkinen
Quantitative analysis of occipital EEG in different stages of Alzheimer's disease.
Electroencephalography and clinical neurophysiology 1985;60(1):1-6.
1984: Hilkka Soininen; A Pitkänen; T Halonen; PJ Riekkinen
Dopamine-beta-hydroxylase and acetylcholinesterase activities of cerebrospinal fluid in Alzheimer's disease.
Acta neurologica Scandinavica 1984;70(1):29-34.
1984: Hilkka Soininen; Jukka Jolkkonen; K J Reinikainen; T O Halonen; PJ Riekkinen
Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type.
Journal of the neurological sciences 1984;63(2):167-72.
1984: M Penttilä; J Partanen; Hilkka Soininen; PJ Riekkinen
[Quantitative EEG in various forms of Alzheimer's disease].
Duodecim; lääketieteellinen aikakauskirja 1984;100(18):1174-9.
1983: Hilkka Soininen; J Partanen; M Puranen; PJ Riekkinen
[EEG and computer tomographic findings in senile dementia].
Duodecim; lääketieteellinen aikakauskirja 1983;99(5):342-6.
1982: Hilkka Soininen; J V Partanen; M Puranen; PJ Riekkinen
EEG and computed tomography in the investigation of patients with senile dementia.
Journal of neurology, neurosurgery, and psychiatry 1982;45(8):711-4.
1982: Hilkka Soininen; O P Heinonen
Clinical and etiological aspects of senile dementia.
European neurology 1982;21(6):401-10.
1982: Hilkka Soininen; V J Partanen; E L Helkala; PJ Riekkinen
EEG findings in senile dementia and normal aging.
Acta neurologica Scandinavica 1982;65(1):59-70.
1982: Hilkka Soininen; M Puranen; PJ Riekkinen
Computed tomography findings in senile dementia and normal aging.
Journal of neurology, neurosurgery, and psychiatry 1982;45(1):50-4.
1981: Hilkka Soininen; T Halonen; PJ Riekkinen
Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type.
Acta neurologica Scandinavica 1981;64(3):217-24.
1981: Hilkka Soininen; E MacDonald; M Rekonen; PJ Riekkinen
Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type.
Acta neurologica Scandinavica 1981;64(2):101-7.
1980: V S Partanen; Hilkka Soininen; M Saksa; PJ Riekkinen
Electromyographic and nerve conduction findings in a patient with neuromyotonia, normocalcemic tetany and small-cell lung cancer.
Acta neurologica Scandinavica 1980;61(4):216-26.