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Hilkka Soininen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Vepsäläinen S; Helisalmi S; Mannermaa A; Pirttilä T; Soininen H; Hiltunen M
Combined risk effects of IDE and NEP gene variants on Alzheimer disease.
Simmons Andrew; Westman Eric; Muehlboeck Sebastian; Mecocci Patrizia; Vellas Bruno; Tsolaki Magda; Kloszewska Iwona; Wahlund Lars-Olof; Soininen Hilkka; Lovestone Simon; Evans Alan; Spenger Christian;
MRI measures of Alzheimer's disease and the AddNeuroMed study.
Lovestone Simon; Francis Paul; Kloszewska Iwona; Mecocci Patrizia; Simmons Andrew; Soininen Hilkka; Spenger Christian; Tsolaki Magda; Vellas Bruno; Wahlund Lars-Olof; Ward Malcolm;
AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.

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All Publications

2009: Vepsäläinen S; Helisalmi S; Mannermaa A; Pirttilä T; Soininen H; Hiltunen M
Combined risk effects of IDE and NEP gene variants on Alzheimer disease.
Journal of neurology, neurosurgery, and psychiatry 2009;80(11):1268-70.
2009: Simmons Andrew; Westman Eric; Muehlboeck Sebastian; Mecocci Patrizia; Vellas Bruno; Tsolaki Magda; Kloszewska Iwona; Wahlund Lars-Olof; Soininen Hilkka; Lovestone Simon; Evans Alan; Spenger Christian;
MRI measures of Alzheimer's disease and the AddNeuroMed study.
Annals of the New York Academy of Sciences 2009;1180():47-55.
2009: Lovestone Simon; Francis Paul; Kloszewska Iwona; Mecocci Patrizia; Simmons Andrew; Soininen Hilkka; Spenger Christian; Tsolaki Magda; Vellas Bruno; Wahlund Lars-Olof; Ward Malcolm;
AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.
Annals of the New York Academy of Sciences 2009;1180():36-46.
2009: Solomon Alina; Leoni Valerio; Kivipelto Miia; Besga Ariadna; Oksengård Anne Rita; Julin Per; Svensson Leif; Wahlund Lars-Olof; Andreasen Niels; Winblad Bengt; Soininen Hilkka; Björkhem Ingemar
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.
Neuroscience letters 2009;462(1):89-93.
2009: Ferris Steven; Nordberg Agneta; Soininen Hilkka; Darreh-Shori Taher; Lane Roger
Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment.
Pharmacogenetics and genomics 2009;19(8):635-46.
2009: Laakso Mikko P; Tervo Susanna; Hänninen Tuomo; Vanhanen Matti; Hallikainen Merja; Soininen Hilkka
Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(7):891-5.
2009: Visser Pieter Jelle; Verhey Frans; Knol Dirk L; Scheltens Philip; Wahlund Lars-Olof; Freund-Levi Yvonne; Tsolaki Magda; Minthon Lennart; Wallin Asa K; Hampel Harald; Bürger Katharina; Pirttila Tuula; Soininen Hilkka; Rikkert Marcel Olde; Verbeek Marcel M; Spiru Luiza; Blennow Kaj
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.
Lancet neurology 2009;8(7):619-27.
2009: Hiltunen Mikko; Mäkinen Petra; Peräniemi Sirpa; Sivenius Juhani; van Groen Thomas; Soininen Hilkka; Jolkkonen Jukka
Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.
Neurobiology of disease 2009;35(1):103-13.
2009: Viswanathan Jayashree; Mäkinen Petra; Helisalmi Seppo; Haapasalo Annakaisa; Soininen Hilkka; Hiltunen Mikko
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(5):747-50.
2009: Peskind E; Nordberg A; Darreh-Shori T; Soininen H
Safety of lumbar puncture procedures in patients with Alzheimer's disease.
Current Alzheimer research 2009;6(3):290-2.
2009: Solomon A; Kåreholt I; Ngandu T; Wolozin B; Macdonald S W S; Winblad B; Nissinen A; Tuomilehto J; Soininen H; Kivipelto M
Serum total cholesterol, statins and cognition in non-demented elderly.
Neurobiology of aging 2009;30(6):1006-9.
2009: Lu Alice; Hiltunen Mikko; Romano Donna M; Soininen Hilkka; Hyman Bradley T; Bertram Lars; Tanzi Rudolph E
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Pihlajamäki Maija; Jauhiainen Anne M; Soininen Hilkka
Structural and functional MRI in mild cognitive impairment.
Current Alzheimer research 2009;6(2):179-85.
2009: Tapiola Tero; Alafuzoff Irina; Herukka Sanna-Kaisa; Parkkinen Laura; Hartikainen Päivi; Soininen Hilkka; Pirttilä Tuula
Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.
Archives of neurology 2009;66(3):382-9.
2009: Nordberg Agneta; Darreh-Shori Taher; Peskind Elaine; Soininen Hilkka; Mousavi Malahat; Eagle Gina; Lane Roger
Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.
Current Alzheimer research 2009;6(1):4-14.
2009: Jauhiainen Anne M; Pihlajamäki Maija; Tervo Susanna; Niskanen Eini; Tanila Heikki; Hänninen Tuomo; Vanninen Ritva L; Soininen Hilkka
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment.
Hippocampus 2009;19(2):166-75.
2009: Alafuzoff I; Aho L; Helisalmi S; Mannermaa A; Soininen H
Beta-amyloid deposition in brains of subjects with diabetes.
Neuropathology and applied neurobiology 2009;35(1):60-8.
2009: Eskelinen Marjo H; Ngandu Tiia; Tuomilehto Jaakko; Soininen Hilkka; Kivipelto Miia
Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.
Journal of Alzheimer's disease : JAD 2009;16(1):85-91.
2009: Håkansson Krister; Rovio Suvi; Helkala Eeva-Liisa; Vilska Anna-Riitta; Winblad Bengt; Soininen Hilkka; Nissinen Aulikki; Mohammed Abdul H; Kivipelto Miia
Association between mid-life marital status and cognitive function in later life: population based cohort study.
BMJ (Clinical research ed.) 2009;339():b2462.
2009: Helisalmi Seppo; Väkevä Antti; Hiltunen Mikko; Soininen Hilkka
Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease.
Dementia and geriatric cognitive disorders 2009;27(4):318-21.
2008: Bertram Lars; Schjeide Brit-Maren M; Hooli Basavaraj; Mullin Kristina; Hiltunen Mikko; Soininen Hilkka; Ingelsson Martin; Lannfelt Lars; Blacker Deborah; Tanzi Rudolph E
No association between CALHM1 and Alzheimer's disease risk.
Cell 2008;135(6):993-4; author reply 994-6.
2008: Kivipelto Miia; Rovio Suvi; Ngandu Tiia; Kåreholt Ingemar; Eskelinen Marjo; Winblad Bengt; Hachinski Vladimir; Cedazo-Minguez Angel; Soininen Hilkka; Tuomilehto Jaakko; Nissinen Aulikki
Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study.
Journal of cellular and molecular medicine 2008;12(6B):2762-71.
2008: Tukiainen Taru; Tynkkynen Tuulia; Mäkinen Ville-Petteri; Jylänki Pasi; Kangas Antti; Hokkanen Johanna; Vehtari Aki; Gröhn Olli; Hallikainen Merja; Soininen Hilkka; Kivipelto Miia; Groop Per-Henrik; Kaski Kimmo; Laatikainen Reino; Soininen Pasi; Pirttilä Tuula; Ala-Korpela Mika
A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.
Biochemical and biophysical research communications 2008;375(3):356-61.
2008: Leinonen Ville; Alafuzoff Irina; Aalto Sargo; Suotunen Timo; Savolainen Sakari; Någren Kjell; Tapiola Tero; Pirttilä Tuula; Rinne Jaakko; Jääskeläinen Juha E; Soininen Hilkka; Rinne Juha O
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.
Archives of neurology 2008;65(10):1304-9.
2008: Tiihonen Jari; Rossi Roberta; Laakso Mikko P; Hodgins Sheilagh; Testa Cristina; Perez Jorge; Repo-Tiihonen Eila; Vaurio Olli; Soininen Hilkka; Aronen Hannu J; Könönen Mervi; Thompson Paul M; Frisoni Giovanni B
Brain anatomy of persistent violent offenders: more rather than less.
Psychiatry research 2008;163(3):201-12.
2008: Helisalmi Seppo; Tarvainen Timo; Vepsäläinen Saila; Koivisto Anne Mari; Hiltunen Mikko; Soininen Hilkka
Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease.
Neuroscience letters 2008;441(2):233-6.
2008: Julkunen Petro; Jauhiainen Anne M; Westerén-Punnonen Susanna; Pirinen Eriikka; Soininen Hilkka; Könönen Mervi; Pääkkönen Ari; Määttä Sara; Karhu Jari
Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: a pilot study.
Journal of neuroscience methods 2008;172(2):270-6.
2008: Eskelinen Marjo H; Ngandu Tiia; Helkala Eeva-Liisa; Tuomilehto Jaakko; Nissinen Aulikki; Soininen Hilkka; Kivipelto Miia
Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study.
International journal of geriatric psychiatry 2008;23(7):741-7.
2008: Vepsäläinen Saila; Hiltunen Mikko; Helisalmi Seppo; Wang Jun; van Groen Thomas; Tanila Heikki; Soininen Hilkka
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.
Neuroscience letters 2008;438(2):216-20.
2008: Lämsä R; Helisalmi S; Herukka S-K; Tapiola T; Pirttilä T; Vepsäläinen S; Hiltunen M; Soininen H
Genetic study evaluating LDLR polymorphisms and Alzheimer's disease.
Neurobiology of aging 2008;29(6):848-55.
2008: Herukka Sanna-Kaisa; Pennanen Corina; Soininen Hilkka; Pirttilä Tuula
CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy.
Journal of Alzheimer's disease : JAD 2008;14(1):51-7.
2008: Helisalmi S; Vepsäläinen S; Hiltunen M; Koivisto A M; Salminen A; Laakso M; Soininen H
Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.
Journal of neurology 2008;255(5):668-73.
2008: Lane Roger; Feldman Howard H; Meyer Joanne; He Yunsheng; Ferris Steven H; Nordberg Agneta; Darreh-Shori Taher; Soininen Hilkka; Pirttilä Tuula; Farlow Martin R; Sfikas Nikolaos; Ballard Clive; Greig Nigel H
Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.
Pharmacogenetics and genomics 2008;18(4):289-98.
2008: Blom Elin S; Viswanathan Jayashree; Kilander Lena; Helisalmi Seppo; Soininen Hilkka; Lannfelt Lars; Ingelsson Martin; Glaser Anna; Hiltunen Mikko
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease.
European journal of human genetics : EJHG 2008;16(2):171-5.
2008: Mäkinen Susanna; van Groen Thomas; Clarke Jared; Thornell Anders; Corbett Dale; Hiltunen Mikko; Soininen Hilkka; Jolkkonen Jukka
Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):263-8.
2008: Tapiola Tero; Pennanen Corina; Tapiola Mia; Tervo Susanna; Kivipelto Miia; Hänninen Tuomo; Pihlajamäki Maija; Laakso Mikko P; Hallikainen Merja; Hämäläinen Anne; Vanhanen Matti; Helkala Eeva-Liisa; Vanninen Ritva; Nissinen Aulikki; Rossi Roberta; Frisoni Giovanni B; Soininen Hilkka
MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study.
Neurobiology of aging 2008;29(1):31-8.
2008: Jauhiainen Anne M; Kangasmaa Tuija; Rusanen Minna; Niskanen Eini; Tervo Susanna; Kivipelto Miia; Vanninen Ritva L; Kuikka Jyrki T; Soininen Hilkka
Differential hypometabolism patterns according to mild cognitive impairment subtypes.
Dementia and geriatric cognitive disorders 2008;26(6):490-8.
2008: Koivunen J; Pirttilä T; Kemppainen N; Aalto S; Herukka S-K; Jauhianen A M; Hänninen T; Hallikainen M; Någren K; Rinne J O; Soininen H
PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment.
Dementia and geriatric cognitive disorders 2008;26(4):378-83.
2008: Kovacs Gabor G; Alafuzoff Irina; Al-Sarraj Safa; Arzberger Thomas; Bogdanovic Nenad; Capellari Sabina; Ferrer Isidro; Gelpi Ellen; Kövari Viktor; Kretzschmar Hans; Nagy Zoltan; Parchi Piero; Seilhean Danielle; Soininen Hilkka; Troakes Claire; Budka Herbert
Mixed brain pathologies in dementia: the BrainNet Europe consortium experience.
Dementia and geriatric cognitive disorders 2008;26(4):343-50.
2008: Visser P J; Verhey F R J; Boada M; Bullock R; De Deyn P P; Frisoni G B; Frolich L; Hampel H; Jolles J; Jones R; Minthon L; Nobili F; Olde Rikkert M; Ousset P-J; Rigaud A-S; Scheltens P; Soininen H; Spiru L; Touchon J; Tsolaki M; Vellas B; Wahlund L-O; Wilcock G; Winblad B
Development of screening guidelines and clinical criteria for predementia Alzheimer's disease. The DESCRIPA Study.
Neuroepidemiology 2008;30(4):254-65.
2008: Hämäläinen A; Grau-Olivares M; Tervo S; Niskanen E; Pennanen C; Huuskonen J; Kivipelto M; Hänninen T; Tapiola M; Vanhanen M; Hallikainen M; Helkala E-L; Nissinen A; Vanninen R L; Soininen H
Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.
Neuro-degenerative diseases 2008;5(3-4):186-9.
2007: Sakka Paraskevi; Tsolaki Magda; Hort Jakub; Hager Klaus; Soininen Hilkka; López Pousa Secundino; Li Chunming; Schwam Elias
Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy.
Current medical research and opinion 2007;23(12):3153-65.
2007: Hämäläinen Anne; Pihlajamäki Maija; Tanila Heikki; Hänninen Tuomo; Niskanen Eini; Tervo Susanna; Karjalainen Pasi A; Vanninen Ritva L; Soininen Hilkka
Increased fMRI responses during encoding in mild cognitive impairment.
Neurobiology of aging 2007;28(12):1889-903.
2007: Vepsäläinen Saila; Helisalmi Seppo; Koivisto Anne M; Tapaninen Toni; Hiltunen Mikko; Soininen Hilkka
Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients.
Journal of neurology 2007;254(11):1504-8.
2007: Ngandu T; von Strauss E; Helkala E-L; Winblad B; Nissinen A; Tuomilehto J; Soininen H; Kivipelto M
Education and dementia: what lies behind the association?
Neurology 2007;69(14):1442-50.
2007: Clarke Jared; Thornell Anders; Corbett Dale; Soininen Hilkka; Hiltunen Mikko; Jolkkonen Jukka
Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats.
The European journal of neuroscience 2007;26(7):1845-52.
2007: Hämäläinen Anne; Tervo Susanna; Grau-Olivares Marta; Niskanen Eini; Pennanen Corina; Huuskonen Jari; Kivipelto Miia; Hänninen Tuomo; Tapiola Mia; Vanhanen Matti; Hallikainen Merja; Helkala Eeva-Liisa; Nissinen Aulikki; Vanninen Ritva; Soininen Hilkka
Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment.
NeuroImage 2007;37(4):1122-31.
2007: Lämsä R; Helisalmi S; Hiltunen M; Herukka S-K; Tapiola T; Pirttilä T; Vepsäläinen S; Soininen H
The association study between DHCR24 polymorphisms and Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):906-10.
2007: Rovio Suvi; Kåreholt Ingemar; Viitanen Matti; Winblad Bengt; Tuomilehto Jaakko; Soininen Hilkka; Nissinen Aulikki; Kivipelto Miia
Work-related physical activity and the risk of dementia and Alzheimer's disease.
International journal of geriatric psychiatry 2007;22(9):874-82.
2007: Vepsäläinen Saila; Parkinson Michele; Helisalmi Seppo; Mannermaa Arto; Soininen Hilkka; Tanzi Rudolph E; Bertram Lars; Hiltunen Mikko
Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
Journal of medical genetics 2007;44(9):606-8.
2007: Herukka Sanna-Kaisa; Helisalmi Seppo; Hallikainen Merja; Tervo Susanna; Soininen Hilkka; Pirttilä Tuula
CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI.
Neurobiology of aging 2007;28(4):507-14.
2007: Solomon A; Kåreholt I; Ngandu T; Winblad B; Nissinen A; Tuomilehto J; Soininen H; Kivipelto M
Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study.
Neurology 2007;68(10):751-6.
2007: Joyal C C; Putkonen A; Mancini-Marïe A; Hodgins S; Kononen M; Boulay L; Pihlajamaki M; Soininen H; Stip E; Tiihonen J; Aronen H J
Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study.
Schizophrenia research 2007;91(1-3):97-102.
2007: Niskanen Eini I; Tarvainen Mika P; Kononen Mervi; Soininen Hilkka; Karjalainen Pasi A
Subspace approaches for FMRI time series estimation.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2007;2007():5485-8.
2007: Lamsa R; Helisalmi S; Herukka S-K; Tapiola T; Pirttila T; Vepsalainen S; Hiltunen M; Soininen H
Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers.
Dementia and geriatric cognitive disorders 2007;24(2):146-50.
2007: Ngandu Tiia; Helkala Eeva-Liisa; Soininen Hilkka; Winblad Bengt; Tuomilehto Jaakko; Nissinen Aulikki; Kivipelto Miia
Alcohol drinking and cognitive functions: findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study.
Dementia and geriatric cognitive disorders 2007;23(3):140-9.
2007: Soininen Hilkka; West Christine; Robbins Jeffery; Niculescu Liviu
Long-term efficacy and safety of celecoxib in Alzheimer's disease.
Dementia and geriatric cognitive disorders 2007;23(1):8-21.
2006: Buerger Katharina; Ewers Michael; Pirttilä Tuula; Zinkowski Raymond; Alafuzoff Irina; Teipel Stefan J; DeBernardis John; Kerkman Daniel; McCulloch Cheryl; Soininen Hilkka; Hampel Harald
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):3035-41.
2006: Vanhanen M; Koivisto K; Moilanen L; Helkala E L; Hänninen T; Soininen H; Kervinen K; Kesäniemi Y A; Laakso M; Kuusisto J
Association of metabolic syndrome with Alzheimer disease: a population-based study.
Neurology 2006;67(5):843-7.
2006: Kivipelto Miia; Ngandu Tiia; Laatikainen Tiina; Winblad Bengt; Soininen Hilkka; Tuomilehto Jaakko
Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study.
Lancet neurology 2006;5(9):735-41.
2006: Zhou Xin-Wen; Li Xu; Bjorkdahl Cecilia; Sjogren Magnus J; Alafuzoff Irina; Soininen Hilkka; Grundke-Iqbal Inge; Iqbal Khalid; Winblad Bengt; Pei Jin-Jing
Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains.
Neurobiology of disease 2006;22(3):657-68.
2006: Jönsson Linus; Eriksdotter Jönhagen Maria; Kilander Lena; Soininen Hilkka; Hallikainen Merja; Waldemar Gunhild; Nygaard Harald; Andreasen Niels; Winblad Bengt; Wimo Anders
Determinants of costs of care for patients with Alzheimer's disease.
International journal of geriatric psychiatry 2006;21(5):449-59.
2006: Hiltunen M; Iivonen S; Soininen H
Aromatase enzyme and Alzheimer's disease.
Minerva endocrinologica 2006;31(1):61-73.
2006: Helisalmi S; Vepsäläinen S; Koivisto A M; Mannermaa A; Iivonen S; Hiltunen M; Kiviniemi V; Soininen H
Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary.
Journal of neurology, neurosurgery, and psychiatry 2006;77(3):421-2.
2006: Jönsson Linus; Andreasen Niels; Kilander Lena; Soininen Hilkka; Waldemar Gunhild; Nygaard Harald; Winblad Bengt; Jönhagen Maria Eriksdotter; Hallikainen Merja; Wimo Anders
Patient- and proxy-reported utility in Alzheimer disease using the EuroQoL.
Alzheimer disease and associated disorders 2006;20(1):49-55.
2006: Koivisto Anne M; Helisalmi Seppo; Pihlajamaki Jussi; Hiltunen Mikko; Koivisto Keijo; Moilanen Leena; Kuusisto Johanna; Helkala Eeva-Liisa; Hanninen Tuomo; Kervinen Kari; Kesaniemi Y Antero; Laakso Markku; Soininen Hilkka
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.
Dementia and geriatric cognitive disorders 2006;22(5-6):449-53.
2006: Laitinen M H; Ngandu T; Rovio S; Helkala E-L; Uusitalo U; Viitanen M; Nissinen A; Tuomilehto J; Soininen H; Kivipelto M
Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study.
Dementia and geriatric cognitive disorders 2006;22(1):99-107.
2006: Pennanen Corina; Testa Cristina; Boccardi Marina; Laakso Mikko P; Hallikainen Merja; Helkala Eeva-Liisa; Hänninen Tuomo; Kivipelto Miia; Könönen Mervi; Nissinen Aulikki; Tervo Susanna; Vanhanen Matti; Vanninen Ritva; Frisoni Giovani B; Soininen Hilkka
The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.
Dementia and geriatric cognitive disorders 2006;22(1):60-6.
2006: Winblad B; Wimo A; Engedal K; Soininen H; Verhey F; Waldemar G; Wetterholm A-L; Haglund A; Zhang R; Schindler R
3-year study of donepezil therapy in Alzheimer's disease: effects of early and continuous therapy.
Dementia and geriatric cognitive disorders 2006;21(5-6):353-63.
2006: Iivonen S; Heikkinen T; Puoliväli J; Helisalmi S; Hiltunen M; Soininen H; Tanila H
Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice.
Neuroscience 2006;137(4):1143-52.
2005: Iqbal Khalid; Flory Michael; Khatoon Sabiha; Soininen Hilkka; Pirttila Tuula; Lehtovirta Maarit; Alafuzoff Irina; Blennow Kaj; Andreasen Niels; Vanmechelen Eugeen; Grundke-Iqbal Inge
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.
Annals of neurology 2005;58(5):748-57.
2005: Rovio Suvi; Kåreholt Ingemar; Helkala Eeva-Liisa; Viitanen Matti; Winblad Bengt; Tuomilehto Jaakko; Soininen Hilkka; Nissinen Aulikki; Kivipelto Miia
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.
Lancet neurology 2005;4(11):705-11.
2005: Pihlajamäki Maija; Tanila Heikki; Könönen Mervi; Hänninen Tuomo; Aronen Hannu J; Soininen Hilkka
Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects.
The European journal of neuroscience 2005;22(8):2095-105.
2005: Kivipelto Miia; Ngandu Tiia; Fratiglioni Laura; Viitanen Matti; Kåreholt Ingemar; Winblad Bengt; Helkala Eeva-Liisa; Tuomilehto Jaakko; Soininen Hilkka; Nissinen Aulikki
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.
Archives of neurology 2005;62(10):1556-60.
2005: Miettinen Riitta; Riedel Anett; Kalesnykas Giedrius; Kettunen Hannu-Pekka; Puoliväli Jukka; Soininen Hilkka; Arendt Thomas
Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy.
Journal of chemical neuroanatomy 2005;30(2-3):105-18.
2005: Pirskanen Mia; Hiltunen Mikko; Mannermaa Arto; Helisalmi Seppo; Lehtovirta Maarit; Hänninen Tuomo; Soininen Hilkka
Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women.
European journal of human genetics : EJHG 2005;13(9):1000-6.
2005: Li Xu; Alafuzoff Irina; Soininen Hilkka; Winblad Bengt; Pei Jin-Jing
Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain.
The FEBS journal 2005;272(16):4211-20.
2005: Koivisto Anne M; Helisalmi Seppo; Pihlajamäki Jussi; Moilanen Leena; Kuusisto Johanna; Laakso Markku; Hiltunen Mikko; Keijo Koivisto; Hänninen Tuomo; Helkala Eeva-Liisa; Kervinen Kari; Kesäniemi Y Antero; Soininen Hilkka
Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.
Journal of neurogenetics 2005;19(3-4):155-61.
2005: Herukka Sanna-Kaisa; Hallikainen Merja; Soininen Hilkka; Pirttilä Tuula
CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment.
Neurology 2005;64(7):1294-7.
2005: Vepsäläinen Saila; Castren Eero; Helisalmi Seppo; Iivonen Susan; Mannermaa Arto; Lehtovirta Maarit; Hänninen Tuomo; Soininen Hilkka; Hiltunen Mikko
Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease.
Journal of neurology 2005;252(4):423-8.
2005: Bresciani Lorena; Rossi Roberta; Testa Cristina; Geroldi Cristina; Galluzzi Samantha; Laakso Mikko P; Beltramello Alberto; Soininen Hilkka; Frisoni Giovanni B
Visual assessment of medial temporal atrophy on MR films in Alzheimer's disease: comparison with volumetry.
Aging clinical and experimental research 2005;17(1):8-13.
2005: Frisoni G B; Testa C; Sabattoli F; Beltramello A; Soininen H; Laakso M P
Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study.
Journal of neurology, neurosurgery, and psychiatry 2005;76(1):112-4.
2005: Pennanen C; Testa C; Laakso M P; Hallikainen M; Helkala E-L; Hänninen T; Kivipelto M; Könönen M; Nissinen A; Tervo S; Vanhanen M; Vanninen R; Frisoni G B; Soininen H
A voxel based morphometry study on mild cognitive impairment.
Journal of neurology, neurosurgery, and psychiatry 2005;76(1):11-4.
2005: Boccardi Marina; Sabattoli Francesca; Laakso Mikko P; Testa Cristina; Rossi Roberta; Beltramello Alberto; Soininen Hilkka; Frisoni Giovanni B
Frontotemporal dementia as a neural system disease.
Neurobiology of aging 2005;26(1):37-44.
2005: Chaudhuri J D; Hiltunen M; Nykänen M; Ylä-Herttuala S; Soininen H; Miettinen R
Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods.
Neuroscience 2005;131(2):557-66.
2004: Helisalmi S; Hiltunen M; Vepsäläinen S; Iivonen S; Mannermaa A; Lehtovirta M; Koivisto A M; Alafuzoff I; Soininen H
Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients.
Journal of neurology, neurosurgery, and psychiatry 2004;75(12):1746-8.
2004: Li Xu; An Wen-Lin; Alafuzoff Irina; Soininen Hilkka; Winblad Bengt; Pei Jin-Jing
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain.
Neuroreport 2004;15(14):2237-40.
2004: Kerokoski Petri; Suuronen Tiina; Salminen Antero; Soininen Hilkka; Pirttilä Tuula
Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons.
Neuroscience letters 2004;368(2):181-5.
2004: Anttila Tiia; Helkala Eeva-Liisa; Viitanen Matti; Kåreholt Ingemar; Fratiglioni Laura; Winblad Bengt; Soininen Hilkka; Tuomilehto Jaakko; Nissinen Aulikki; Kivipelto Miia
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study.
BMJ (Clinical research ed.) 2004;329(7465):539.
2004: Helisalmi Seppo; Hiltunen Mikko; Vepsäläinen Saila; Iivonen Susan; Corder Elizabeth H; Lehtovirta Maarit; Mannermaa Arto; Koivisto Anne Maria; Soininen Hilkka
Genetic variation in apolipoprotein D and Alzheimer's disease.
Journal of neurology 2004;251(8):951-7.
2004: Helisalmi S; Dermaut B; Hiltunen M; Mannermaa A; Van den Broeck M; Lehtovirta M; Koivisto A M; Iivonen S; Cruts M; Soininen H; Van Broeckhoven C
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
Neurology 2004;63(1):173-5.
2004: Autere Jaana; Moilanen Jukka S; Finnilä Saara; Soininen Hilkka; Mannermaa Arto; Hartikainen Päivi; Hallikainen Merja; Majamaa Kari
Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia.
Human genetics 2004;115(1):29-35.
2004: Iivonen S; Corder E; Lehtovirta M; Helisalmi S; Mannermaa A; Vepsäläinen S; Hänninen T; Soininen H; Hiltunen M
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease.
Neurology 2004;62(7):1170-6.
2004: Pihlajamäki Maija; Tanila Heikki; Könönen Mervi; Hänninen Tuomo; Hämäläinen Anne; Soininen Hilkka; Aronen Hannu J
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans.
The European journal of neuroscience 2004;19(7):1939-49.
2004: Pennanen Corina; Kivipelto Miia; Tuomainen Susanna; Hartikainen Päivi; Hänninen Tuomo; Laakso Mikko P; Hallikainen Merja; Vanhanen Matti; Nissinen Aulikki; Helkala Eeva-Liisa; Vainio Pauli; Vanninen Ritva; Partanen Kaarina; Soininen Hilkka
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD.
Neurobiology of aging 2004;25(3):303-10.
2004: Testa Cristina; Laakso Mikko P; Sabattoli Francesca; Rossi Roberta; Beltramello Alberto; Soininen Hilkka; Frisoni Giovanni B
A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease.
Journal of magnetic resonance imaging : JMRI 2004;19(3):274-82.
2004: Ruoppi P; Koistinen T; Susitaival P; Honkanen J; Soininen H
Frequency of allergic rhinitis to laboratory animals in university employees as confirmed by chamber challenges.
Allergy 2004;59(3):295-301.
2004: Boccardi M; Sabattoli F; Testa C; Beltramello A; Soininen H; Frisoni G B
APOE and modulation of Alzheimer's and frontotemporal dementia.
Neuroscience letters 2004;356(3):167-70.
2004: Pennanen C; Laakso M P; Kivipelto M; Ramberg J; Soininen H
Serum testosterone levels in males with Alzheimer's disease.
Journal of neuroendocrinology 2004;16(2):95-8.
2004: Jones Roy W; Soininen Hilkka; Hager Klaus; Aarsland Dag; Passmore Peter; Murthy Anita; Zhang Richard; Bahra Ranbir
A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease.
International journal of geriatric psychiatry 2004;19(1):58-67.
2004: Hiltunen Mikko; Helisalmi Seppo; Kivipelto Miia; Soininen Hilkka
[Genetics of Alzheimer's disease]
Duodecim; lääketieteellinen aikakauskirja 2004;120(20):2425-31.
2004: Tervo Susanna; Kivipelto Miia; Hänninen Tuomo; Vanhanen Matti; Hallikainen Merja; Mannermaa Arto; Soininen Hilkka
Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects.
Dementia and geriatric cognitive disorders 2004;17(3):196-203.
2003: Iivonen Susan; Helisalmi Seppo; Mannermaa Arto; Alafuzoff Irina; Lehtovirta Maarit; Soininen Hilkka; Hiltunen Mikko
Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology.
Neuroscience letters 2003;352(2):146-50.
2003: Frisoni G B; Scheltens P h; Galluzzi S; Nobili F M; Fox N C; Robert P H; Soininen H; Wahlund L-O; Waldemar G; Salmon E
Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC.
Journal of neurology, neurosurgery, and psychiatry 2003;74(10):1371-81.
2003: Riedel Anett; Miettinen Riitta; Stieler Jens; Mikkonen Mia; Alafuzoff Irina; Soininen Hilkka; Arendt Thomas
Reelin-immunoreactive Cajal-Retzius cells: the entorhinal cortex in normal aging and Alzheimer's disease.
Acta neuropathologica 2003;106(4):291-302.
2003: Parkkinen Laura; Soininen Hilkka; Alafuzoff Irina
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.
Journal of neuropathology and experimental neurology 2003;62(4):363-7.
2003: Laakso M P; Hiltunen Y; Könönen M; Kivipelto M; Koivisto A; Hallikainen M; Soininen H
Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(3):267-75.
2003: Mattila Kari M; Hiltunen Mikko; Rinne Juha O; Mannermaa Arto; Röyttä Matias; Alafuzoff Irina; Laippala Pekka; Soininen Hilkka; Lehtimäki Terho
Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients.
Neuroscience letters 2003;337(1):61-3.
2003: Boccardi Marina; Laakso Mikko P; Bresciani Lorena; Galluzzi Samantha; Geroldi Cristina; Beltramello Alberto; Soininen Hilkka; Frisoni Giovanni B
The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia.
Neurobiology of aging 2003;24(1):95-103.
2003: Pihlajamäki Maija; Tanila Heikki; Hänninen Tuomo; Könönen Mervi; Mikkonen Mia; Jalkanen Ville; Partanen Kaarina; Aronen Hannu J; Soininen Hilkka
Encoding of novel picture pairs activates the perirhinal cortex: an fMRI study.
Hippocampus 2003;13(1):67-80.
2003: Wimo Anders; Winblad Bengt; Engedal Knut; Soininen Hilkka; Verhey Frans; Waldemar Gunhild; Wetterholm Anna-Lena; Mastey Vera; Haglund Anders; Zhang Richard; Miceli Robert; Chin Warren; Subbiah Ponni;
An economic evaluation of donepezil in mild to moderate Alzheimer's disease: results of a 1-year, double-blind, randomized trial.
Dementia and geriatric cognitive disorders 2003;15(1):44-54.
2002: Helkala E-L; Kivipelto M; Hallikainen M; Alhainen K; Heinonen H; Tuomilehto J; Soininen H; Nissinen A
Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure--a population-based study.
Acta neurologica Scandinavica 2002;106(6):341-6.
2002: Boccardi M; Pennanen C; Laakso M P; Testa C; Geroldi C; Soininen H; Frisoni G B
Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease.
Neuroscience letters 2002;335(2):139-43.
2002: Frisoni G B; Testa C; Zorzan A; Sabattoli F; Beltramello A; Soininen H; Laakso M P
Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry.
Journal of neurology, neurosurgery, and psychiatry 2002;73(6):657-64.
2002: Kerokoski Petri; Suuronen Tiina; Salminen Antero; Soininen Hilkka; Pirttilä Tuula
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Biochemical and biophysical research communications 2002;298(5):693-8.
2002: Kerokoski Petri; Suuronen Tiina; Salminen Antero; Soininen Hilkka; Pirttilä Tuula
Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.
Brain research. Molecular brain research 2002;106(1-2):50-6.
2002: Anttila T; Helkala E-L; Kivipelto M; Hallikainen M; Alhainen K; Heinonen H; Mannermaa A; Tuomilehto J; Soininen H; Nissinen A
Midlife income, occupation, APOE status, and dementia: a population-based study.
Neurology 2002;59(6):887-93.
2002: Autere J M; Hiltunen M J; Mannermaa A J; Jäkälä P A; Hartikainen P H; Majamaa K; Alafuzoff I; Soininen H S
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson's disease in Finland.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2002;9(5):479-83.
2002: Hänninen T; Hallikainen M; Tuomainen S; Vanhanen M; Soininen H
Prevalence of mild cognitive impairment: a population-based study in elderly subjects.
Acta neurologica Scandinavica 2002;106(3):148-54.
2002: Kivipelto Miia; Helkala Eeva-Liisa; Laakso Mikko P; Hänninen Tuomo; Hallikainen Merja; Alhainen Kari; Iivonen Susan; Mannermaa Arto; Tuomilehto Jaakko; Nissinen Aulikki; Soininen Hilkka
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.
Annals of internal medicine 2002;137(3):149-55.
2002: Laakso Mikko P; Gunning-Dixon Faith; Vaurio Olli; Repo-Tiihonen Eila; Soininen Hilkka; Tiihonen Jari
Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism.
Psychiatry research 2002;114(2):95-102.
2002: Kivipelto Miia; Soininen Hilkka; Tuomilehto Jaakko
Hypertension and white matter lesions of the brain.
Journal of hypertension 2002;20(3):387-9.
2002: Tarkka I M; Lehtovirta M; Soininen H; Pääkkönen A; Karhu J; Partanen J
Auditory adaptation is differentially impaired in familial and sporadic Alzheimer's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(1):45-9.
2002: Frisoni Giovanni B; Geroldi Cristina; Beltramello Alberto; Bianchetti Angelo; Binetti Giuliano; Bordiga Giovanni; DeCarli Charles; Laakso Mikko P; Soininen Hilkka; Testa Cristina; Zanetti Orazio; Trabucchi Marco
Radial width of the temporal horn: a sensitive measure in Alzheimer disease.
AJNR. American journal of neuroradiology 2002;23(1):35-47.
2002: Pirskanen Mia; Hiltunen Mikko; Mannermaa Arto; Iivonen Susan; Helisalmi Seppo; Lehtovirta Maarit; Koivisto Anne Maria; Laakso Markku; Soininen Hilkka; Alafuzoff Irina
Interleukin 1 alpha gene polymorphism as a susceptibility factor in Alzheimer's disease and its influence on the extent of histopathological hallmark lesions of Alzheimer's disease.
Dementia and geriatric cognitive disorders 2002;14(3):123-7.
2002: Iivonen S; Hiltunen M; Alafuzoff I; Mannermaa A; Kerokoski P; Puoliväli J; Salminen A; Helisalmi S; Soininen H
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease.
Neuroscience 2002;113(2):301-10.
2002: Kivipelto Miia; Laakso Mikko P; Tuomilehto Jaakko; Nissinen Aulikki; Soininen Hilkka
Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention.
CNS drugs 2002;16(7):435-44.
2001: Clarke N A; Soininen H; Gustafson L; Minthon L; Alhainen K; Francis P T
Tacrine may alter APP-like protein levels in the lumbar CSF of Alzheimer patients.
International journal of geriatric psychiatry 2001;16(11):1104-6.
2001: Hiltunen M; Mannermaa A; Thompson D; Easton D; Pirskanen M; Helisalmi S; Koivisto A M; Lehtovirta M; Ryynänen M; Soininen H
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland.
Neurology 2001;57(9):1663-8.
2001: Hiltunen M; Soininen H
Genes, proteins and brain disease.
Trends in molecular medicine 2001;7(9):382-3.
2001: Parkkinen L; Soininen H; Laakso M; Alafuzoff I
Alpha-synuclein pathology is highly dependent on the case selection.
Neuropathology and applied neurobiology 2001;27(4):314-25.
2001: Winblad B; Engedal K; Soininen H; Verhey F; Waldemar G; Wimo A; Wetterholm A L; Zhang R; Haglund A; Subbiah P;
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD.
Neurology 2001;57(3):489-95.
2001: Pirskanen M; Alafuzoff I; Hiltunen M; Mannermaa A; Helisalmi S; Lehtovirta M; Koivisto A M; Laakso M; Soininen H
An association between a subset of Finnish late-onset Alzheimer's disease and alpha2-macroglobulin.
Neurogenetics 2001;3(3):171-2.
2001: Kivipelto M; Helkala E L; Hänninen T; Laakso M P; Hallikainen M; Alhainen K; Soininen H; Tuomilehto J; Nissinen A
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study.
Neurology 2001;56(12):1683-9.
2001: Finnilä S; Autere J; Lehtovirta M; Hartikainen P; Mannermaa A; Soininen H; Majamaa K
Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNAGln.
Journal of medical genetics 2001;38(6):400-5.
2001: Kivipelto M; Helkala E L; Laakso M P; Hänninen T; Hallikainen M; Alhainen K; Soininen H; Tuomilehto J; Nissinen A
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
BMJ (Clinical research ed.) 2001;322(7300):1447-51.
2001: Tapiola T; Soininen H; Pirttilä T
CSF tau and Abeta42 levels in patients with Down's syndrome.
Neurology 2001;56(7):979-80.
2001: Vanhanen M; Kivipelto M; Koivisto K; Kuusisto J; Mykkänen L; Helkala E L; Hänninen T; Kervinen K; Kesäniemi Y A; Laakso M P; Soininen H; Laakso M
APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.
Neurology 2001;56(5):655-9.
2001: Kraszpulski M; Soininen H; Helisalmi S; Alafuzoff I
The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer's disease.
Acta neurologica Scandinavica 2001;103(2):88-92.
2001: Kerokoski P; Suuronen T; Salminen A; Soininen H; Pirttilä T
The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.
Biochemical and biophysical research communications 2001;280(4):998-1002.
2001: Kerokoski P; Soininen H; Pirttilä T
Beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality.
Neurochemistry international 2001;38(2):127-34.
2001: Laakso M P; Vaurio O; Koivisto E; Savolainen L; Eronen M; Aronen H J; Hakola P; Repo E; Soininen H; Tiihonen J
Psychopathy and the posterior hippocampus.
Behavioural brain research 2001;118(2):187-93.
2001: Mikkonen M; Soininen H; Alafuzof I; Miettinen R
Hippocampal plasticity in Alzheimer's disease.
Reviews in the neurosciences 2001;12(4):311-25.
2000: Overmyer M; Kraszpulski M; Helisalmi S; Soininen H; Alafuzoff I
DNA fragmentation, gliosis and histological hallmarks of Alzheimer's disease.
Acta neuropathologica 2000;100(6):681-7.
2000: Reynolds W F; Hiltunen M; Pirskanen M; Mannermaa A; Helisalmi S; Lehtovirta M; Alafuzoff I; Soininen H
MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.
Neurology 2000;55(9):1284-90.
2000: Koivisto A M; Lempiäinen P; Koivisto K; Helkala E L; Mykkänen L; Kuusisto J; Kervinen K; Kesäniemi Y A; Laakso M; Soininen H
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.
Neuroepidemiology 2000;19(6):327-32.
2000: Tapiola T; Pirttilä T; Mehta P D; Alafuzofff I; Lehtovirta M; Soininen H
Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease.
Neurobiology of aging 2000;21(5):735-40.
2000: Laakso M P; Frisoni G B; Könönen M; Mikkonen M; Beltramello A; Geroldi C; Bianchetti A; Trabucchi M; Soininen H; Aronen H J
Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study.
Biological psychiatry 2000;47(12):1056-63.
2000: Helisalmi S; Valve R; Karvonen M K; Hiltunen M; Pirskanen M; Mannermaa A; Koulu M; Pesonen U; Uusitupa M; Soininen H
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
Neuroscience letters 2000;287(1):25-8.
2000: Laakso M P; Vaurio O; Savolainen L; Repo E; Soininen H; Aronen H J; Tiihonen J
A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism.
Behavioural brain research 2000;109(2):177-86.
2000: Hiltunen M; Helisalmi S; Mannermaa A; Alafuzoff I; Koivisto A M; Lehtovirta M; Pirskanen M; Sulkava R; Verkkoniemi A; Soininen H
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?
European journal of human genetics : EJHG 2000;8(4):259-66.
2000: Alafuzoff I; Helisalmi S; Mannermaa A; Soininen H
Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia.
Annals of the New York Academy of Sciences 2000;903():244-51.
2000: Pihlajamäki M; Tanila H; Hänninen T; Könönen M; Laakso M; Partanen K; Soininen H; Aronen H J
Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study.
Annals of neurology 2000;47(4):470-6.
2000: Lehtovirta M; Laakso M P; Frisoni G B; Soininen H
How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies.
Neurobiology of aging 2000;21(2):293-300.
2000: Laakso M P; Lehtovirta M; Partanen K; Riekkinen P J; Soininen H
Hippocampus in Alzheimer's disease: a 3-year follow-up MRI study.
Biological psychiatry 2000;47(6):557-61.
2000: Alafuzoff I; Helisalmi S; Heinonen E H; Reinikainen K; Hallikainen M; Soininen H; Koivisto K
Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease.
European journal of clinical pharmacology 2000;55(11-12):815-9.
2000: Savolainen S; Laakso M P; Paljärvi L; Alafuzoff I; Hurskainen H; Partanen K; Soininen H; Vapalahti M
MR imaging of the hippocampus in normal pressure hydrocephalus: correlations with cortical Alzheimer's disease confirmed by pathologic analysis.
AJNR. American journal of neuroradiology 2000;21(2):409-14.
2000: Tapiola T; Pirttilä T; Mikkonen M; Mehta P D; Alafuzoff I; Koivisto K; Soininen H
Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and 40 concentrations in Alzheimer's disease.
Neuroscience letters 2000;280(2):119-22.
2000: Helisalmi S; Hiltunen M; Mannermaa A; Koivisto A M; Lehtovirta M; Alafuzoff I; Ryynänen M; Soininen H
Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer's disease?
Neuroscience letters 2000;278(1-2):65-8.
2000: Lehtovirta M; Partanen J; Könönen M; Hiltunen J; Helisalmi S; Hartikainen P; Riekkinen P; Soininen H
A longitudinal quantitative EEG study of Alzheimer's disease: relation to apolipoprotein E polymorphism.
Dementia and geriatric cognitive disorders 2000;11(1):29-35.
2000: Geroldi C; Laakso M P; DeCarli C; Beltramello A; Bianchetti A; Soininen H; Trabucchi M; Frisoni G B
Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study.
Journal of neurology, neurosurgery, and psychiatry 2000;68(1):93-6.
2000: Partanen K; Laakso M; Erkinjuntti T; Soininen H
[Imaging diagnostics in early dementia]
Duodecim; lääketieteellinen aikakauskirja 2000;116(10):1049-58.
2000: Soininen H; Sulkava R
[When should the brain imaging be done in suspected dementia?]
Duodecim; lääketieteellinen aikakauskirja 2000;116(10):1037-8.
2000: Jagger C; Andersen K; Breteler M M; Copeland J R; Helmer C; Baldereschi M; Fratiglioni L; Lobo A; Soininen H; Hofman A; Launer L J
Prognosis with dementia in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Neurology 2000;54(11 Suppl 5):S16-20.
2000: Fratiglioni L; Launer L J; Andersen K; Breteler M M; Copeland J R; Dartigues J F; Lobo A; Martinez-Lage J; Soininen H; Hofman A
Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Neurology 2000;54(11 Suppl 5):S10-5.
2000: Lobo A; Launer L J; Fratiglioni L; Andersen K; Di Carlo A; Breteler M M; Copeland J R; Dartigues J F; Jagger C; Martinez-Lage J; Soininen H; Hofman A
Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Neurology 2000;54(11 Suppl 5):S4-9.
2000: Mikkonen M; Pitkänen A; Soininen H; Alafuzoff I; Miettinen R
Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow.
Neuroscience 2000;96(3):515-22.
2000: Laakso M P; Hallikainen M; Hänninen T; Partanen K; Soininen H
Diagnosis of Alzheimer's disease: MRI of the hippocampus vs delayed recall.
Neuropsychologia 2000;38(5):579-84.
1999: Geroldi C; Pihlajamäki M; Laakso M P; DeCarli C; Beltramello A; Bianchetti A; Soininen H; Trabucchi M; Frisoni G B
APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD.
Neurology 1999;53(8):1825-32.
1999: Helisalmi S; Hiltunen M; Valonen P; Mannermaa A; Koivisto A M; Lehtovirta M; Ryynänen M; Soininen H
Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.
Journal of neurology 1999;246(9):821-4.
1999: Hiltunen M; Mannermaa A; Koivisto A M; Lehtovirta M; Helisalmi S; Ryynänen M; Riekkinen P; Soininen H
Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients.
European journal of human genetics : EJHG 1999;7(6):652-8.
1999: Vanhanen M; Kuusisto J; Koivisto K; Mykkänen L; Helkala E L; Hänninen T; Riekkinen P; Soininen H; Laakso M
Type-2 diabetes and cognitive function in a non-demented population.
Acta neurologica Scandinavica 1999;100(2):97-101.
1999: Overmyer M; Helisalmi S; Soininen H; Laakso M; Riekkinen P; Alafuzoff I
Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue.
Dementia and geriatric cognitive disorders 1999;10(4):252-7.
1999: Alafuzoff I; Hartikainen P; Hanninen T; Partanen K; Kuikka J; Syrjänen K; Naukkarinen A; Soininen H
Rapidly progressive multifocal leukoencephalopathy with substantial cell-mediated inflammatory response and with cognitive decline of non-Alzheimer type in a 75-year-old female patient.
Clinical neuropathology 1999;18(3):113-23.
1999: Mikkonen M; Soininen H; Tapiola T; Alafuzoff I; Miettinen R
Hippocampal plasticity in Alzheimer's disease: changes in highly polysialylated NCAM immunoreactivity in the hippocampal formation.
The European journal of neuroscience 1999;11(5):1754-64.
1999: Overmyer M; Helisalmi S; Soininen H; Laakso M; Riekkinen P; Alafuzoff I
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.
Acta neuropathologica 1999;97(4):383-92.
1999: Juottonen K; Laakso M P; Partanen K; Soininen H
Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease.
AJNR. American journal of neuroradiology 1999;20(1):139-44.
1999: Frisoni G B; Laakso M P; Beltramello A; Geroldi C; Bianchetti A; Soininen H; Trabucchi M
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease.
Neurology 1999;52(1):91-100.
1999: Hänninen T; Soininen H
[Mild cognitive impairment as an early sign of dementia]
Duodecim; lääketieteellinen aikakauskirja 1999;115(4):381-8.
1999: Turunen J; Loula P; Soininen H
Automatization of physicians' phone-in hours.
Studies in health technology and informatics 1999;68():621-4.
1999: Mikkonen M; Alafuzoff I; Tapiola T; Soininen H; Miettinen R
Subfield- and layer-specific changes in parvalbumin, calretinin and calbindin-D28K immunoreactivity in the entorhinal cortex in Alzheimer's disease.
Neuroscience 1999;92(2):515-32.
1998: Soininen H S; Scheltens P
Early diagnostic indices for the prevention of Alzheimer's disease.
Annals of medicine 1998;30(6):553-9.
1998: Vanhanen M; Soininen H
Glucose intolerance, cognitive impairment and Alzheimer's disease.
Current opinion in neurology 1998;11(6):673-7.
1998: Mikkonen M; Soininen H; Kälviänen R; Tapiola T; Ylinen A; Vapalahti M; Paljärvi L; Pitkänen A
Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex.
Annals of neurology 1998;44(6):923-34.
1998: Kraszpulski M; Soininen H; Riekkinen P; Alafuzoff I
Pitfalls in the quantitative estimation of beta-amyloid immunoreactivity in human brain tissue.
Histochemistry and cell biology 1998;110(4):439-45.
1998: Juottonen K; Lehtovirta M; Helisalmi S; Riekkinen P J; Soininen H
Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.
Journal of neurology, neurosurgery, and psychiatry 1998;65(3):322-7.
1998: Tapiola T; Lehtovirta M; Pirttilä T; Alafuzoff I; Riekkinen P; Soininen H
Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer's disease.
Lancet 1998;352(9124):287.
1998: Hiltunen M; Mannermaa A; Helisalmi S; Koivisto A; Lehtovirta M; Ryynänen M; Riekkinen P; Soininen H
Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients.
Neuroscience letters 1998;250(1):69-71.
1998: Pirttilä T; Koivisto K; Mehta P D; Reinikainen K; Kim K S; Kilkku O; Heinonen E; Soininen H; Riekkinen P; Wisniewski H M
Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease.
Neuroscience letters 1998;249(1):21-4.
1998: Lehtovirta M; Kuikka J; Helisalmi S; Hartikainen P; Mannermaa A; Ryynänen M; Riekkinen PSr; Soininen H
Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism.
Journal of neurology, neurosurgery, and psychiatry 1998;64(6):742-6.
1998: Riekkinen P; Kejonen K; Laakso M P; Soininen H; Partanen K; Riekkinen M
Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson's disease patients.
Neuroreport 1998;9(7):1507-11.
1998: Riekkinen M; Kejonen K; Jäkälä P; Soininen H; Riekkinen P
Reduction of noradrenaline impairs attention and dopamine depletion slows responses in Parkinson's disease.
The European journal of neuroscience 1998;10(4):1429-35.
1998: Insausti R; Juottonen K; Soininen H; Insausti A M; Partanen K; Vainio P; Laakso M P; Pitkänen A
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices.
AJNR. American journal of neuroradiology 1998;19(4):659-71.
1998: Vanhanen M; Koivisto K; Kuusisto J; Mykkänen L; Helkala E L; Hänninen T; Riekkinen P; Soininen H; Laakso M
Cognitive function in an elderly population with persistent impaired glucose tolerance.
Diabetes care 1998;21(3):398-402.
1998: Riekkinen M; Soininen H; Riekkinen P; Kuikka J; Laakso M; Helkala E L; Partanen J; Riekkinen P
Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease.
Neuroscience 1998;83(2):471-9.
1998: Sorvari H; Miettinen R; Soininen H; Paljärvi L; Karkola K; Pitkänen A
Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala.
Brain research 1998;783(2):355-8.
1998: Laakso M P; Soininen H; Partanen K; Lehtovirta M; Hallikainen M; Hänninen T; Helkala E L; Vainio P; Riekkinen P J
MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity, and analysis of the incorrectly classified subjects.
Neurobiology of aging 1998;19(1):23-31.
1998: Juottonen K; Laakso M P; Insausti R; Lehtovirta M; Pitkänen A; Partanen K; Soininen H
Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease.
Neurobiology of aging 1998;19(1):15-22.
1998: Tapiola T; Lehtovirta M; Ramberg J; Helisalmi S; Linnaranta K; Riekkinen P; Soininen H
CSF tau is related to apolipoprotein E genotype in early Alzheimer's disease.
Neurology 1998;50(1):169-74.
1997: Korhonen P; Huotari V; Soininen H; Salminen A
Glutamate-induced changes in the DNA-binding complexes of transcription factor YY1 in cultured hippocampal and cerebellar granule cells.
Brain research. Molecular brain research 1997;52(2):330-3.
1997: Tapiola T; Overmyer M; Lehtovirta M; Helisalmi S; Ramberg J; Alafuzoff I; Riekkinen P; Soininen H
The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease.
Neuroreport 1997;8(18):3961-3.
1997: Hänninen T; Soininen H
Age-associated memory impairment. Normal aging or warning of dementia?
Drugs & aging 1997;11(6):480-9.
1997: Mikkonen M; Soininen H; Pitkänen A
Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex.
The Journal of comparative neurology 1997;388(1):64-88.
1997: Riekkinen P; Pääkkönen A; Karhu J; Partanen J; Soininen H; Laakso M; Riekkine P
THA disrupts mismatch negativity in Alzheimer disease.
Psychopharmacology 1997;133(2):203-6.
1997: Salminen A; Helenius M; Lahtinen T; Korhonen P; Tapiola T; Soininen H; Solovyan V
Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence.
Biochemical and biophysical research communications 1997;238(3):712-6.
1997: Helisalmi S; Mannermaa A; Lehtovirta M; Ryynänen M; Riekkinen P; Soininen H
No association between alpha1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease.
Neuroscience letters 1997;231(1):56-8.
1997: Jäkälä P; Hänninen T; Ryynänen M; Laakso M; Partanen K; Mannermaa A; Soininen H
Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes.
The Journal of clinical investigation 1997;100(2):331-8.
1997: Riekkinen P; Riekkinen M; Soininen H; Kuikka J; Laakso M; Riekkinen P
Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease.
Neuroreport 1997;8(8):1845-9.
1997: Vanhanen M; Koivisto K; Karjalainen L; Helkala E L; Laakso M; Soininen H; Riekkinen P
Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function.
Neuroreport 1997;8(6):1527-30.
1997: Riekkinen P; Soininen H; Partanen J; Pääkkönen A; Helisalmi S; Riekkinen P
The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients.
Psychopharmacology 1997;129(3):285-8.
1997: Hänninen T; Hallikainen M; Koivisto K; Partanen K; Laakso M P; Riekkinen P J; Soininen H
Decline of frontal lobe functions in subjects with age-associated memory impairment.
Neurology 1997;48(1):148-53.
1997: Pirttilä T; Soininen H; Mehta P D; Heinonen O; Lehtimäki T; Bogdanovic N; Paljärvi L; Kim K S; Kosunen O; Winblad B; Riekkinen P; Wisniewski H M
Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains.
Neurobiology of aging 1997;18(1):121-7.
1997: Soininen H
[Treatment of Alzheimer's disease]
Duodecim; lääketieteellinen aikakauskirja 1997;113(18):1739-46.
1997: Partanen J; Soininen H; Helkala E L; Könönen M; Kilpeläinen R; Riekkinen P
Relationship between EEG reactivity and neuropsychological tests in vascular dementia.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(8-9):905-12.
1997: Laakso M P; Juottonen K; Partanen K; Vainio P; Soininen H
MRI volumetry of the hippocampus: the effect of slice thickness on volume formation.
Magnetic resonance imaging 1997;15(2):263-5.
1996: Helkala E L; Hänninen T; Hallikainen M; Könönen M; Laakso M P; Hartikainen P; Soininen H; Partanen J; Partanen K; Vainio P; Riekkinen P
Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer's disease patients.
Behavioral neuroscience 1996;110(6):1235-43.
1996: Sorvari H; Soininen H; Pitkänen A
Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex.
Neuroscience 1996;75(2):421-43.
1996: Partanen J; Soininen H; Könönen M; Kilpeläinen R; Helkala E L; Riekkinen P
EEG reactivity correlates with neuropsychological test scores in Down's syndrome.
Acta neurologica Scandinavica 1996;94(4):242-6.
1996: Sorvari H; Miettinen R; Soininen H; Pitkänen A
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study.
Neuroscience letters 1996;217(2-3):93-6.
1996: Laakso M P; Partanen K; Soininen H; Lehtovirta M; Hallikainen M; Hänninen T; Helkala E L; Vainio P; Riekkinen P J
MR T2 relaxometry in Alzheimer's disease and age-associated memory impairment.
Neurobiology of aging 1996;17(4):535-40.
1996: Lehtovirta M; Partanen J; Könönen M; Soininen H; Helisalmi S; Mannermaa A; Ryynänen M; Hartikainen P; Riekkinen P
Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism.
Neurobiology of aging 1996;17(4):523-6.
1996: Soininen H S; Riekkinen P J
Apolipoprotein E, memory and Alzheimer's disease.
Trends in neurosciences 1996;19(6):224-8.
1996: Pitkänen A; Laakso M; Kälviäinen R; Partanen K; Vainio P; Lehtovirta M; Riekkinen P; Soininen H
Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease.
Neurology 1996;46(6):1724-30.
1996: Lehtovirta M; Soininen H; Laakso M P; Partanen K; Helisalmi S; Mannermaa A; Ryynänen M; Kuikka J; Hartikainen P; Riekkinen P J
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele.
Journal of neurology, neurosurgery, and psychiatry 1996;60(6):644-9.
1996: Pirttilä T; Soininen H; Heinonen O; Lehtimäki T; Bogdanovic N; Paljärvi L; Kosunen O; Winblad B; Riekkinen P; Wisniewski H M; Mehta P D
Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls.
Brain research 1996;722(1-2):71-7.
1996: Sorvari H; Soininen H; Pitkänen A
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex.
The Journal of comparative neurology 1996;369(2):188-208.
1996: Hanninen T; Koivisto K; Reinikainen K J; Helkala E L; Soininen H; Mykkänen L; Laakso M; Riekkinen P J
Prevalence of ageing-associated cognitive decline in an elderly population.
Age and ageing 1996;25(3):201-5.
1996: Laakso M P; Partanen K; Riekkinen P; Lehtovirta M; Helkala E L; Hallikainen M; Hanninen T; Vainio P; Soininen H
Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study.
Neurology 1996;46(3):678-81.
1996: Helisalmi S; Mannermaa A; Lehtovirta M; Ryynänen M; Riekkinen P; Soininen H
Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease.
Neuroscience letters 1996;205(1):68-70.
1996: Helisalmi S; Linnaranta K; Lehtovirta M; Mannermaa A; Heinonen O; Ryynänen M; Riekkinen P; Soininen H
Apolipoprotein E polymorphism in patients with different neurodegenerative disorders.
Neuroscience letters 1996;205(1):61-4.
1996: Pirttilä T; Mehta P D; Soininen H; Kim K S; Heinonen O; Paljärvi L; Kosunen O; Riekkinen P; Wisniewski H M
Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: correlations with amyloid load in the brain.
Archives of neurology 1996;53(2):189-93.
1996: Lehtovirta M; Soininen H; Helisalmi S; Mannermaa A; Helkala E L; Hartikainen P; Hänninen T; Ryynänen M; Riekkinen P J
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.
Neurology 1996;46(2):413-9.
1996: Kosunen O; Soininen H; Paljärvi L; Heinonen O; Talasniemi S; Riekkinen P J
Diagnostic accuracy of Alzheimer's disease: a neuropathological study.
Acta neuropathologica 1996;91(2):185-93.
1995: Soininen H; Lehtovirta M; Helisalmi S; Linnaranta K; Heinonen O; Riekkinen P
Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele.
Neuroreport 1995;6(18):2518-20.
1995: Laakso M P; Partanen K; Lehtovirta M; Hallikainen M; Hänninen T; Vainio P; Riekkinen P; Soininen H
MRI of amygdala fails to diagnose early Alzheimer's disease.
Neuroreport 1995;6(17):2414-8.
1995: Sorvari H; Soininen H; Paljärvi L; Karkola K; Pitkänen A
Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex.
The Journal of comparative neurology 1995;360(2):185-212.
1995: Hänninen T; Hallikainen M; Koivisto K; Helkala E L; Reinikainen K J; Soininen H; Mykkänen L; Laakso M; Pyörälä K; Riekkinen P J
A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia.
Journal of the American Geriatrics Society 1995;43(9):1007-15.
1995: Heinonen O; Lehtovirta M; Soininen H; Helisalmi S; Mannermaa A; Sorvari H; Kosunen O; Paljärvi L; Ryynänen M; Riekkinen P J
Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.
Neurobiology of aging 1995;16(4):505-13.
1995: Riekkinen P; Kuikka J; Soininen H; Helkala E L; Hallikainen M; Riekkinen P
Tetrahydroaminoacridine modulates technetium-99m labelled ethylene dicysteinate retention in Alzheimer's disease measured with single photon emission computed tomography imaging.
Neuroscience letters 1995;195(1):53-6.
1995: Lehtovirta M; Laakso M P; Soininen H; Helisalmi S; Mannermaa A; Helkala E L; Partanen K; Ryynänen M; Vainio P; Hartikainen P
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes.
Neuroscience 1995;67(1):65-72.
1995: Riekkinen P; Soininen H; Helkala E L; Partanen K; Laakso M; Vanhanen M; Riekkinen P
Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease.
Neuroreport 1995;6(9):1297-300.
1995: Kosunen O; Talasniemi S; Lehtovirta M; Heinonen O; Helisalmi S; Mannermaa A; Paljärvi L; Ryynänen M; Riekkinen P J; Soininen H
Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients.
Stroke; a journal of cerebral circulation 1995;26(5):743-8.
1995: Soininen H S; Karhu J; Partanen J; Pääkkönen A; Jousmäki V; Hänninen T; Hallikainen M; Partanen K; Laakso M P; Koivisto K
Habituation of auditory N100 correlates with amygdaloid volumes and frontal functions in age-associated memory impairment.
Physiology & behavior 1995;57(5):927-35.
1995: Laakso M; Soininen H; Partanen K; Hallikainen M; Lehtovirta M; Hänninen T; Vainio P; Riekkinen P J
The interuncal distance in Alzheimer disease and age-associated memory impairment.
AJNR. American journal of neuroradiology 1995;16(4):727-34.
1995: Soininen H; Kosunen O; Helisalmi S; Mannermaa A; Paljärvi L; Talasniemi S; Ryynänen M; Riekkinen P
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele.
Neuroscience letters 1995;187(2):79-82.
1995: Soininen H; Partanen K; Pitkänen A; Hallikainen M; Hänninen T; Helisalmi S; Mannermaa A; Ryynänen M; Koivisto K; Riekkinen P
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele.
Neurology 1995;45(2):391-2.
1995: Lehtovirta M; Helisalmi S; Mannermaa A; Soininen H; Koivisto K; Ryynänen M; Riekkinen P
Apolipoprotein E polymorphism and Alzheimer's disease in eastern Finland.
Neuroscience letters 1995;185(1):13-5.
1995: Heinonen O; Soininen H; Sorvari H; Kosunen O; Paljärvi L; Koivisto E; Riekkinen P J
Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease.
Neuroscience 1995;64(2):375-84.
1995: Soininen H; Helkala E L; Kuikka J; Hartikainen P; Lehtovirta M; Riekkinen P J
Regional cerebral blood flow measured by 99mTc-HMPAO SPECT differs in subgroups of Alzheimer's disease.
Journal of neural transmission. Parkinson's disease and dementia section 1995;9(2-3):95-109.
1995: Laakso M P; Soininen H; Partanen K; Helkala E L; Hartikainen P; Vainio P; Hallikainen M; Hänninen T; Riekkinen P J
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions.
Journal of neural transmission. Parkinson's disease and dementia section 1995;9(1):73-86.
1994: Soininen H S; Partanen K; Pitkänen A; Vainio P; Hänninen T; Hallikainen M; Koivisto K; Riekkinen P J
Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory.
Neurology 1994;44(9):1660-8.
1994: Heinonen O; Soininen H; Syrjänen S; Neittaanmäki H; Paljärvi L; Kosunen O; Syrjänen K; Riekkinen P
beta-Amyloid protein immunoreactivity in skin is not a reliable marker of Alzheimer's disease. An autopsy-controlled study.
Archives of neurology 1994;51(8):799-804.
1994: Partanen J; Hartikainen P; Könönen M; Jousmäki V; Soininen H; Riekkinen P
Prolonged latencies of pattern reversal visual evoked early potentials in Alzheimer disease.
Alzheimer disease and associated disorders 1994;8(4):250-8.
1994: Heinonen O; Kurvinen K; Soininen H; Koponen H; Syrjänen S; Riekkinen P J
Testing for mutations in exon 17 of the beta-amyloid precursor protein gene in Finnish Alzheimer patients and normal subjects.
Journal of neural transmission. Parkinson's disease and dementia section 1994;7(3):211-5.
1993: Laulumaa V; Kuikka J T; Soininen H; Bergström K; Länsimies E; Riekkinen P
Imaging of D2 dopamine receptors of patients with Parkinson's disease using single photon emission computed tomography and iodobenzamide I 123.
Archives of neurology 1993;50(5):509-12.
1993: Soininen H; Partanen J; Jousmäki V; Helkala E L; Vanhanen M; Majuri S; Kaski M; Hartikainen P; Riekkinen P
Age-related cognitive decline and electroencephalogram slowing in Down's syndrome as a model of Alzheimer's disease.
Neuroscience 1993;53(1):57-63.
1993: Heinonen O; Syrjänen S; Soininen H; Talasniemi S; Kaski M; Mäntyjärvi R; Syrjänen K; Riekkinen P
Circulating immune complexes in sera from patients with Alzheimer's disease, multi-infarct dementia and Down's syndrome.
Neuroscience letters 1993;149(1):67-70.
1993: Soininen H; Reinikainen K J; Puranen M; Helkala E L; Paljärvi L; Riekkinen P J
Wide third ventricle correlates with low choline acetyltransferase activity of the neocortex in Alzheimer patients.
Alzheimer disease and associated disorders 1993;7(1):39-47.
1993: Soininen H; Heinonen O; Hallikainen M; Hänninen T; Koivisto K; Syrjänen S; Talasniemi S; Riekkinen P J
Circulating immune complexes in sera from patients with Alzheimer's disease and subjects with age-associated memory impairment.
Journal of neural transmission. Parkinson's disease and dementia section 1993;6(3):179-88.
1993: Hartikainen P; Helkala E L; Soininen H; Riekkinen P
Cognitive and memory deficits in untreated Parkinson's disease and amyotrophic lateral sclerosis patients: a comparative study.
Journal of neural transmission. Parkinson's disease and dementia section 1993;6(2):127-37.
1993: Soininen H; Riekkinen P
[Regulation of attention]
Duodecim; lääketieteellinen aikakauskirja 1993;109(21):2001-6.
1992: Soininen H; Puranen M; Helkala E L; Laakso M; Riekkinen P J
Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population.
Neurobiology of aging 1992;13(6):717-21.
1992: Soininen H; Reinikainen K J; Partanen J; Helkala E L; Paljärvi L; Riekkinen P J
Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer's disease.
Neuroscience 1992;49(3):529-35.
1992: Hartikainen P; Soininen H; Partanen J; Helkala E L; Riekkinen P
Aging and spectral analysis of EEG in normal subjects: a link to memory and CSF AChE.
Acta neurologica Scandinavica 1992;86(2):148-55.
1992: Soininen H; Reinikainen K; Partanen J; Mervaala E; Paljärvi L; Helkala E L; Riekkinen P
Slowing of the dominant occipital rhythm in electroencephalogram is associated with low concentration of noradrenaline in the thalamus in patients with Alzheimer's disease.
Neuroscience letters 1992;137(1):5-8.
1992: Soininen H; Syrjänen S; Heinonen O; Neittaanmäki H; Miettinen R; Paljärvi L; Syrjänen K; Beyreuther K; Riekkinen P
Amyloid beta-protein deposition in skin of patients with dementia.
Lancet 1992;339(8787):245.
1992: Soininen H; Helkala E L; Laulumaa V; Soikkeli R; Hartikainen P; Riekkinen P J
Cognitive profile of Alzheimer patients with extrapyramidal signs: a longitudinal study.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(3):241-54.
1992: Soininen H; Riekkinen P J
EEG in diagnostics and follow-up of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1992;139():36-9.
1992: Soininen H; Laulumaa V; Helkala E L; Hartikainen P; Riekkinen P J
Extrapyramidal signs in Alzheimer's disease: a 3-year follow-up study.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(2):107-19.
1992: Hartikainen P; Reinikainen K J; Soininen H; Sirviö J; Soikkeli R; Riekkinen P J
Neurochemical markers in the cerebrospinal fluid of patients with Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and normal controls.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(1):53-68.
1991: Soininen H; Partanen J; Laulumaa V; Pääkkönen A; Helkala E L; Riekkinen P J
Serial EEG in Alzheimer's disease: 3 year follow-up and clinical outcome.
Electroencephalography and clinical neurophysiology 1991;79(5):342-8.
1991: Soikkeli R; Partanen J; Soininen H; Pääkkönen A; Riekkinen P
Slowing of EEG in Parkinson's disease.
Electroencephalography and clinical neurophysiology 1991;79(3):159-65.
1991: Alhainen K; Partanen J; Reinikainen K; Laulumaa V; Soininen H; Airaksinen M; Riekkinen P
Discrimination of tetrahydroaminoacridine responders by a single dose pharmaco-EEG in patients with Alzheimer's disease.
Neuroscience letters 1991;127(1):113-6.
1991: Helkala E L; Laulumaa V; Soikkeli R; Partanen J; Soininen H; Riekkinen P J
Slow-wave activity in the spectral analysis of the electroencephalogram is associated with cortical dysfunctions in patients with Alzheimer's disease.
Behavioral neuroscience 1991;105(3):409-15.
1991: Helkala E L; Laulumaa V; Soininen H; Partanen J; Riekkinen P J
Different patterns of cognitive decline related to normal or deteriorating EEG in a 3-year follow-up study of patients with Alzheimer's disease.
Neurology 1991;41(4):528-32.
1991: Nousiainen U; Partanen J; Koivisto K; Soininen H; Riekkinen P J
Electroneuromyographic findings in patients with Alzheimer's disease.
Electromyography and clinical neurophysiology 1991;31(2):119-22.
1991: Soininen H; Partanen J; Pääkkönen A; Koivisto E; Riekkinen P J
Changes in absolute power values of EEG spectra in the follow-up of Alzheimer's disease.
Acta neurologica Scandinavica 1991;83(2):133-6.
1991: Riekkinen P; Buzsaki G; Riekkinen P; Soininen H; Partanen J
The cholinergic system and EEG slow waves.
Electroencephalography and clinical neurophysiology 1991;78(2):89-96.
1991: Hartikainen P; Soininen H; Reinikainen K J; Sirviö J; Soikkeli R; Riekkinen P J
Neurotransmitter markers in the cerebrospinal fluid of normal subjects. Effects of aging and other confounding factors.
Journal of neural transmission. General section 1991;84(1-2):103-17.
1990: Reinikainen K J; Soininen H; Riekkinen P J
Neurotransmitter changes in Alzheimer's disease: implications to diagnostics and therapy.
Journal of neuroscience research 1990;27(4):576-86.
1990: Soininen H; Unni L; Shillcutt S
Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain.
Neurochemical research 1990;15(12):1185-90.
1990: Soininen H
[Examination of a patient with dementia]
Duodecim; lääketieteellinen aikakauskirja 1990;106(12):947-54.
1989: Koponen H; Stenbäck U; Mattila E; Reinikainen K; Soininen H; Riekkinen P J
Cerebrospinal fluid somatostatin in delirium.
Psychological medicine 1989;19(3):605-9.
1989: Koponen H; Stenbäck U; Mattila E; Soininen H; Reinikainen K; Riekkinen P J
Delirium among elderly persons admitted to a psychiatric hospital: clinical course during the acute stage and one-year follow-up.
Acta psychiatrica Scandinavica 1989;79(6):579-85.
1989: Koponen H; Hurri L; Stenbäck U; Mattila E; Soininen H; Riekkinen P J
Computed tomography findings in delirium.
The Journal of nervous and mental disease 1989;177(4):226-31.
1989: Koponen H; Stenbäck U; Mattila E; Reinikainen K; Soininen H; Riekkinen P J
CSF beta-endorphin-like immunoreactivity in delirium.
Biological psychiatry 1989;25(7):938-44.
1989: Soininen H; Partanen J; Laulumaa V; Helkala E L; Laakso M; Riekkinen P J
Longitudinal EEG spectral analysis in early stage of Alzheimer's disease.
Electroencephalography and clinical neurophysiology 1989;72(4):290-7.
1989: Sirviö J; Kutvonen R; Soininen H; Hartikainen P; Riekkinen P J
Cholinesterases in the cerebrospinal fluid, plasma, and erythrocytes of patients with Alzheimer's disease.
Journal of neural transmission 1989;75(2):119-27.
1989: Helkala E L; Laulumaa V; Soininen H; Riekkinen P J
Different error pattern of episodic and semantic memory in Alzheimer's disease and Parkinson's disease with dementia.
Neuropsychologia 1989;27(10):1241-8.
1988: Helkala E L; Laulumaa V; Soininen H; Riekkinen P J
Recall and recognition memory in patients with Alzheimer's and Parkinson's diseases.
Annals of neurology 1988;24(2):214-7.
1988: Reinikainen K J; Paljärvi L; Huuskonen M; Soininen H; Laakso M; Riekkinen P J
A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease.
Journal of the neurological sciences 1988;84(1):101-16.
1988: Reinikainen K J; Riekkinen P J; Paljärvi L; Soininen H; Helkala E L; Jolkkonen J; Laakso M
Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data.
Neurochemical research 1988;13(2):135-46.
1988: Soininen H; Riekkinen P J; Partanen J; Helkala E L; Laulumaa V; Jolkkonen J; Reinikainen K
Cerebrospinal fluid somatostatin correlates with spectral EEG variables and with parietotemporal cognitive dysfunction in Alzheimer patients.
Neuroscience letters 1988;85(1):131-6.
1987: Sirviö J; Soininen H S; Kutvonen R; Hyttinen J M; Helkala E L; Riekkinen P J
Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease.
Journal of the neurological sciences 1987;81(2-3):273-9.
1987: Jolkkonen J; Lehtinen M; Soininen H; Sennef C; Riekkinen P
Enhanced monoaminergic neurotransmission by desglycinamide-arginine-vasopressin in human subjects.
Neuroscience letters 1987;76(3):312-5.
1987: Riekkinen P; Legros J J; Sennef C; Jolkkonen J; Smitz S; Soininen H
Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects.
Peptides 1987;8(2):261-5.
1987: Jolkkonen J T; Soininen H S; Riekkinen P J
beta-Endorphin-like immunoreactivity in cerebrospinal fluid of patients with Alzheimer's disease and Parkinson's disease.
Journal of the neurological sciences 1987;77(2-3):153-9.
1987: Reinikainen K J; Riekkinen P J; Jolkkonen J; Kosma V M; Soininen H
Decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in Alzheimer's disease.
Brain research 1987;402(1):103-8.
1987: Riekkinen P J; Soininen H; Sirviö J; Reinikainen K; Helkala E L; Paljärvi L
Dementia without cholinergic deficit.
Gerontology 1987;33(3-4):268-72.
1987: Riekkinen P J; Laulumaa V; Sirviö J; Soininen H; Helkala E L
Recent progress in the research of Alzheimer's disease.
Medical biology 1987;65(2-3):83-8.
1986: Jolkkonen J; Soininen H; Halonen T; Ylinen A; Laulumaa V; Laakso M; Riekkinen P
Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia.
Journal of neurology, neurosurgery, and psychiatry 1986;49(12):1374-7.
1986: Partanen J V; Soininen H; Riekkinen P J
Does an ACTH derivative (Org 2766) prevent deterioration of EEG in Alzheimer's disease?
Electroencephalography and clinical neurophysiology 1986;63(6):547-51.
1985: Soininen H; Koskinen T; Helkala E L; Pigache R; Riekkinen P J
Treatment of Alzheimer's disease with a synthetic ACTH 4-9 analog.
Neurology 1985;35(9):1348-51.
1985: Jolkkonen J T; Soininen H S; Riekkinen P J
The effect of ACTH4-9 analog (Org2766) on some cerebrospinal fluid parameters in patients with Alzheimer's disease.
Life sciences 1985;37(7):585-90.
1985: Penttilä M; Partanen J V; Soininen H; Riekkinen P J
Quantitative analysis of occipital EEG in different stages of Alzheimer's disease.
Electroencephalography and clinical neurophysiology 1985;60(1):1-6.
1984: Soininen H; Pitkänen A; Halonen T; Riekkinen P J
Dopamine-beta-hydroxylase and acetylcholinesterase activities of cerebrospinal fluid in Alzheimer's disease.
Acta neurologica Scandinavica 1984;70(1):29-34.
1984: Soininen H S; Jolkkonen J T; Reinikainen K J; Halonen T O; Riekkinen P J
Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type.
Journal of the neurological sciences 1984;63(2):167-72.
1984: Penttilä M; Partanen J; Soininen H; Riekkinen P
[Quantitative EEG in various forms of Alzheimer's disease]
Duodecim; lääketieteellinen aikakauskirja 1984;100(18):1174-9.
1983: Soininen H; Partanen J; Puranen M; Riekkinen P
[EEG and computer tomographic findings in senile dementia]
Duodecim; lääketieteellinen aikakauskirja 1983;99(5):342-6.
1982: Soininen H; Partanen J V; Puranen M; Riekkinen P J
EEG and computed tomography in the investigation of patients with senile dementia.
Journal of neurology, neurosurgery, and psychiatry 1982;45(8):711-4.
1982: Soininen H; Partanen V J; Helkala E L; Riekkinen P J
EEG findings in senile dementia and normal aging.
Acta neurologica Scandinavica 1982;65(1):59-70.
1982: Soininen H; Puranen M; Riekkinen P J
Computed tomography findings in senile dementia and normal aging.
Journal of neurology, neurosurgery, and psychiatry 1982;45(1):50-4.
1982: Soininen H; Heinonen O P
Clinical and etiological aspects of senile dementia.
European neurology 1982;21(6):401-10.
1981: Soininen H; Halonen T; Riekkinen P J
Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type.
Acta neurologica Scandinavica 1981;64(3):217-24.
1981: Soininen H; MacDonald E; Rekonen M; Riekkinen P J
Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type.
Acta neurologica Scandinavica 1981;64(2):101-7.
1980: Partanen V S; Soininen H; Saksa M; Riekkinen P
Electromyographic and nerve conduction findings in a patient with neuromyotonia, normocalcemic tetany and small-cell lung cancer.
Acta neurologica Scandinavica 1980;61(4):216-26.

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