Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

John Solaro

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Chemicals & Drugs

Disorders

Myocardial Contraction

Living Beings

Phenomena

Phosphorylation

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
22
de Tombe, Pieter
20
Wolska, Beata
16
Kobayashi, Tomoyoshi
13
Arteaga, Grace
13
Wieczorek, David
11
Martin, Anne
10
Sumandea, Marius
8
Buttrick, Peter
8
Kranias, Evangelia
7
Ke, Yunbo
7
Rosevear, Paul
7
Pyle, Glen
6
Rajan, Sudarsan
6
Urboniene, Dalia
6
Geenen, David

Sign-in to see all Coauthors

Publications

TOP 3
Engel Patti L; Hinken Aaron; Solaro R John
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments.
Jagatheesan Ganapathy; Rajan Sudarsan; Schulz Emily M; Ahmed Rafeeq P H; Petrashevskaya Natalia; Schwartz Arnold; Boivin Greg P; Arteaga Grace M; Wang Tao; Wang Yi-Gang; Ashraf Muhammad; Liggett Stephen B; Lorenz John; Solaro R John; Wieczorek David F
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
Warren Chad M; Kobayashi Tomoyoshi; Solaro R John
Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of John Solaro (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Engel Patti L; Hinken Aaron; Solaro R John
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments.
Journal of molecular and cellular cardiology 2009;47(3):359-64.
2009: Jagatheesan Ganapathy; Rajan Sudarsan; Schulz Emily M; Ahmed Rafeeq P H; Petrashevskaya Natalia; Schwartz Arnold; Boivin Greg P; Arteaga Grace M; Wang Tao; Wang Yi-Gang; Ashraf Muhammad; Liggett Stephen B; Lorenz John; Solaro R John; Wieczorek David F
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H181-90.
2009: Warren Chad M; Kobayashi Tomoyoshi; Solaro R John
Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex.
The Journal of biological chemistry 2009;284(21):14258-66.
2009: Hartman Thomas J; Martin Jody L; Solaro R John; Samarel Allen M; Russell Brenda
CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms.
American journal of physiology. Cell physiology 2009;296(5):C1034-9.
2009: Solaro R John
CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease.
IDrugs : the investigational drugs journal 2009;12(4):243-51.
2009: Abraham Sherwin J; Kobayashi Tomoyoshi; Solaro R John; Gaponenko Vadim
Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins.
Journal of biomolecular NMR 2009;43(4):239-46.
2009: Scruggs Sarah B; Hinken Aaron C; Thawornkaiwong Ariyaporn; Robbins Jeffrey; Walker Lori A; de Tombe Pieter P; Geenen David L; Buttrick Peter M; Solaro R John
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.
The Journal of biological chemistry 2009;284(8):5097-106.
2009: Solaro R John
Maintaining cooperation among cardiac myofilament proteins through thick and thin.
The Journal of physiology 2009;587(Pt 1):3.
2009: Sheehan Katherine A; Ke Yunbo; Wolska Beata M; Solaro R John
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes.
American journal of physiology. Cell physiology 2009;296(1):C47-58.
2008: Ke Yunbo; Solaro R John
Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation.
Biologics : targets & therapy 2008;2(4):903-9.
2008: Baudenbacher Franz; Schober Tilmann; Pinto Jose Renato; Sidorov Veniamin Y; Hilliard Fredrick; Solaro R John; Potter James D; Knollmann Björn C
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.
The Journal of clinical investigation 2008;118(12):3893-903.
2008: Ke Yunbo; Lei Ming; Solaro R John
Regulation of cardiac excitation and contraction by p21 activated kinase-1.
Progress in biophysics and molecular biology 2008;98(2-3):238-50.
2008: Solaro R John
Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins.
The Journal of biological chemistry 2008;283(40):26829-33.
2008: Rudy Yoram; Ackerman Michael J; Bers Donald M; Clancy Colleen E; Houser Steven R; London Barry; McCulloch Andrew D; Przywara Dennis A; Rasmusson Randall L; Solaro R John; Trayanova Natalia A; Van Wagoner David R; Varró András; Weiss James N; Lathrop David A
Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.
Circulation 2008;118(11):1202-11.
2008: Yuan Chao; Sheng Quanhu; Tang Haixu; Li Yixue; Zeng Rong; Solaro R John
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.
American journal of physiology. Heart and circulatory physiology 2008;295(2):H647-56.
2008: Sumandea Marius P; Rybin Vitalyi O; Hinken Aaron C; Wang Chaojian; Kobayashi Tomoyoshi; Harleton Erin; Sievert Gail; Balke C William; Feinmark Steven J; Solaro R John; Steinberg Susan F
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
The Journal of biological chemistry 2008;283(33):22680-9.
2008: Tachampa Kittipong; Kobayashi Tomoyoshi; Wang Helen; Martin Anne F; Biesiadecki Brandon J; Solaro R John; de Tombe Pieter P
Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle.
The Journal of biological chemistry 2008;283(22):15114-21.
2008: Solaro R John; Rosevear Paul; Kobayashi Tomoyoshi
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation.
Biochemical and biophysical research communications 2008;369(1):82-7.
2008: Solaro R John; de Tombe Pieter P
Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function.
Cardiovascular research 2008;77(4):616-8.
2008: Warren Chad M; Arteaga Grace M; Rajan Sudarsan; Ahmed Rafeeq P H; Wieczorek David F; Solaro R John
Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.
Proteomics 2008;8(1):100-5.
2008: Minami Hiroaki; Wolska Beata M; Stojanovic Miroslav O; Solaro R John
Reversal of effects of acidosis on contraction of rat heart myocytes by CGP-48506.
Frontiers in bioscience : a journal and virtual library 2008;13():5638-45.
2007: Solaro R John
Mechanisms of the Frank-Starling law of the heart: the beat goes on.
Biophysical journal 2007;93(12):4095-6.
2007: Howarth Jack W; Meller Jarek; Solaro R John; Trewhella Jill; Rosevear Paul R
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin.
Journal of molecular biology 2007;373(3):706-22.
2007: Wu Steven C; Solaro R John
Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins.
The Journal of biological chemistry 2007;282(42):30691-8.
2007: Lei Ming; Ke Yunbo; Solaro R John
Pak1: steps towards understanding the regulatory mechanisms of pacemaker function of the heart.
Future cardiology 2007;3(5):473-6.
2007: Sheehan Katherine A; Ke Yunbo; Solaro R John
p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R963-73.
2007: Jagatheesan Ganapathy; Rajan Sudarsan; Petrashevskaya Natalia; Schwartz Arnold; Boivin Greg; Arteaga Grace M; Solaro R John; Liggett Stephen B; Wieczorek David F
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H949-58.
2007: Solaro R John
Translational medicine with a capital T, troponin T, that is.
Circulation research 2007;101(2):114-5.
2007: Belin Rashad J; Sumandea Marius P; Allen Edward J; Schoenfelt Kelly; Wang Helen; Solaro R John; de Tombe Pieter P
Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure.
Circulation research 2007;101(2):195-204.
2007: Rajan Sudarsan; Ahmed Rafeeq P H; Jagatheesan Ganapathy; Petrashevskaya Natalia; Boivin Greg P; Urboniene Dalia; Arteaga Grace M; Wolska Beata M; Solaro R John; Liggett Stephen B; Wieczorek David F
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Circulation research 2007;101(2):205-14.
2007: Xiao Lei; Zhao Qiong; Du Yanmei; Yuan Chao; Solaro R John; Buttrick Peter M
PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.
Biochemistry 2007;46(23):7054-61.
2007: Ke Yunbo; Lei Ming; Collins Thomas P; Rakovic Stevan; Mattick Paul A D; Yamasaki Michiko; Brodie Mark S; Terrar Derek A; Solaro R John
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells.
Circulation research 2007;100(9):1317-27.
2007: Solaro R John
Nitroxyl effects on myocardium provide new insights into the significance of altered myofilament response to calcium in the regulation of contractility.
The Journal of physiology 2007;580(Pt.3):697.
2007: Davis Jonathan P; Norman Catalina; Kobayashi Tomoyoshi; Solaro R John; Swartz Darl R; Tikunova Svetlana B
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C.
Biophysical journal 2007;92(9):3195-206.
2007: Hinken Aaron C; Solaro R John
A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation.
Physiology (Bethesda, Md.) 2007;22():73-80.
2007: Ke Yunbo; Lum Hazel; Solaro R John
Inhibition of endothelial barrier dysfunction by P21-activated kinase-1.
Canadian journal of physiology and pharmacology 2007;85(3-4):281-8.
2007: Vahebi Susan; Ota Asuka; Li Manxiang; Warren Chad M; de Tombe Pieter P; Wang Yibin; Solaro R John
p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
Circulation research 2007;100(3):408-15.
2007: Bupha-Intr Tepmanas; Wattanapermpool Jonggonnee; Peña James R; Wolska Beata M; Solaro R J
Myofilament response to Ca2+ and Na+/H+ exchanger activity in sex hormone-related protection of cardiac myocytes from deactivation in hypercapnic acidosis.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(2):R837-43.
2007: Engel Patti L; Kobayashi Tomoyoshi; Biesiadecki Brandon; Davis Jonathan; Tikunova Svetlana; Wu Steven; Solaro R John
Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.
The Journal of biological chemistry 2007;282(1):183-93.
2007: Nowak Grzegorz; Peña James R; Urboniene Dalia; Geenen David L; Solaro R John; Wolska Beata M
Correlations between alterations in length-dependent Ca2+ activation of cardiac myofilaments and the end-systolic pressure-volume relation.
Journal of muscle research and cell motility 2007;28(7-8):415-9.
2007: Solaro R John; Arteaga Grace M
Heart failure, ischemia/reperfusion injury and cardiac troponin.
Advances in experimental medicine and biology 2007;592():191-200.
2006: Belin Rashad J; Sumandea Marius P; Kobayashi Tomoyoshi; Walker Lori A; Rundell Veronica L; Urboniene Dalia; Yuzhakova Milana; Ruch Stuart H; Geenen David L; Solaro R John; de Tombe Pieter P
Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2344-53.
2006: Pyle W Glen; La Rotta Gustavo; de Tombe Pieter P; Sumandea Marius P; Solaro R John
Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ.
Journal of molecular and cellular cardiology 2006;41(3):537-43.
2006: McCall Shannon J; Nassar Rashid; Malouf Nadia N; Saunders Aleister J; Oakeley Annette E; Henderson Paul M; Solaro R John; Pielak Gary J; Alexander Kenneth A; Anderson Page A W
Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit.
Pediatric research 2006;60(3):276-81.
2006: Biesiadecki Brandon J; Solaro R John
When hearts fail so does skeletal muscle: breaking a vicious cycle.
Circulation research 2006;98(12):1456-8.
2006: Kobayashi Tomoyoshi; Solaro R John
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I.
The Journal of biological chemistry 2006;281(19):13471-7.
2006: Scruggs Sarah B; Walker Lori A; Lyu Theodore; Geenen David L; Solaro R John; Buttrick Peter M; Goldspink Paul H
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation.
Journal of molecular and cellular cardiology 2006;40(4):465-73.
2006: Kass David A; Solaro R John
Mechanisms and use of calcium-sensitizing agents in the failing heart.
Circulation 2006;113(2):305-15.
2005: Arteaga Grace M; Warren Chad M; Milutinovic Sanja; Martin Anne F; Solaro R John
Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction.
American journal of physiology. Heart and circulatory physiology 2005;289(5):H2183-92.
2005: Vahebi S; Solaro R J
Cardiac sarcomeric function, small G-protein signaling, and heart failure.
Panminerva medica 2005;47(3):133-42.
2005: Urboniene Dalia; Dias Fernando A L; Peña James R; Walker Lori A; Solaro R John; Wolska Beata M
Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia.
Circulation research 2005;97(1):70-7.
2005: Layland Joanne; Cave Alison C; Warren Chad; Grieve David J; Sparks Emma; Kentish Jonathan C; Solaro R John; Shah Ajay M
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1137-9.
2005: Solaro R John
Remote control of A-band cardiac thin filaments by the I-Z-I protein network of cardiac sarcomeres.
Trends in cardiovascular medicine 2005;15(4):148-52.
2005: Vahebi Susan; Kobayashi Tomoyoshi; Warren Chad M; de Tombe Pieter P; Solaro R John
Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin.
Circulation research 2005;96(7):740-7.
2005: Layland Joanne; Solaro R John; Shah Ajay M
Regulation of cardiac contractile function by troponin I phosphorylation.
Cardiovascular research 2005;66(1):12-21.
2005: Kobayashi Tomoyoshi; Yang Xiaofeng; Walker Lori A; Van Breemen Richard B; Solaro R John
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C.
Journal of molecular and cellular cardiology 2005;38(1):213-8.
2005: Kobayashi Tomoyoshi; Solaro R John
Calcium, thin filaments, and the integrative biology of cardiac contractility.
Annual review of physiology 2005;67():39-67.
2004: Parmacek Michael S; Solaro R John
Biology of the troponin complex in cardiac myocytes.
Progress in cardiovascular diseases 2004;47(3):159-76.
2004: Sorsa Tia; Pollesello Piero; Solaro R John
The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.
Molecular and cellular biochemistry 2004;266(1-2):87-107.
2004: Towbin Jeffrey A; Solaro R John
Genetics of dilated cardiomyopathy: more genes that kill.
Journal of the American College of Cardiology 2004;44(10):2041-3.
2004: Gomes Aldrin V; Venkatraman Gayathri; Davis Jonathan P; Tikunova Svetlana B; Engel Patti; Solaro R John; Potter James D
Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart.
The Journal of biological chemistry 2004;279(48):49579-87.
2004: Jagatheesan Ganapathy; Rajan Sudarsan; Petrashevskaya Natalia; Schwartz Arnold; Boivin Greg; Arteaga Grace; de Tombe Pieter P; Solaro R John; Wieczorek David F
Physiological significance of troponin T binding domains in striated muscle tropomyosin.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1484-94.
2004: Goldspink Paul H; Montgomery David E; Walker Lori A; Urboniene Dalia; McKinney Ronald D; Geenen David L; Solaro R John; Buttrick Peter M
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.
Circulation research 2004;95(4):424-32.
2004: Roman Brian B; Goldspink Paul H; Spaite Elyse; Urboniene Dalia; McKinney Ron; Geenen David L; Solaro R John; Buttrick Peter M
Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo.
American journal of physiology. Heart and circulatory physiology 2004;286(6):H2089-95.
2004: Sumandea Marius P; Burkart Eileen M; Kobayashi Tomoyoshi; De Tombe Pieter P; Solaro R John
Molecular and integrated biology of thin filament protein phosphorylation in heart muscle.
Annals of the New York Academy of Sciences 2004;1015():39-52.
2004: Kobayashi Tomoyoshi; Dong Wen-Ji; Burkart Eileen M; Cheung Herbert C; Solaro R John
Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation.
Biochemistry 2004;43(20):5996-6004.
2004: Layland Joanne; Grieve David J; Cave Alison C; Sparks Emma; Solaro R John; Shah Ajay M
Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically.
The Journal of physiology 2004;556(Pt 3):835-47.
2004: Yang Xiaofeng; Wu Huaping; Kobayashi Tomoyoshi; Solaro R John; van Breemen Richard B
Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry.
Analytical chemistry 2004;76(5):1532-6.
2004: Pyle W Glen; Solaro R John
At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function.
Circulation research 2004;94(3):296-305.
2004: Ke Yunbo; Wang Lynn; Pyle W Glen; de Tombe Pieter P; Solaro R John
Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes.
Circulation research 2004;94(2):194-200.
2004: Maughan David; Warshaw David; Alpert Norman; Lewinter Martin; Solaro R John; Holubarsch Christian; Yamada Kazuhiro
Conference report: fifth international conference on muscle energetics, July 2001.
Journal of muscle research and cell motility 2004;25(8):667-70.
2003: Burkart Eileen M; Arteaga Grace M; Sumandea Marius P; Prabhakar Rethinasamy; Wieczorek David F; Solaro R John
Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2003;35(10):1285-93.
2003: Sumandea Marius P; Pyle W Glen; Kobayashi Tomoyoshi; de Tombe Pieter P; Solaro R John
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T.
The Journal of biological chemistry 2003;278(37):35135-44.
2003: Jagatheesan Ganapathy; Rajan Sudarsan; Petrashevskaya Natalia; Schwartz Arnold; Boivin Greg; Vahebi Susan; DeTombe Pieter; Solaro R John; Labitzke Erin; Hilliard George; Wieczorek David F
Functional importance of the carboxyl-terminal region of striated muscle tropomyosin.
The Journal of biological chemistry 2003;278(25):23204-11.
2003: Konhilas John P; Irving Thomas C; Wolska Beata M; Jweied Eias E; Martin Anne F; Solaro R John; de Tombe Pieter P
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.
The Journal of physiology 2003;547(Pt 3):951-61.
2003: Burkart Eileen M; Sumandea Marius P; Kobayashi Tomoyoshi; Nili Mahta; Martin Anne F; Homsher Earl; Solaro R John
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity.
The Journal of biological chemistry 2003;278(13):11265-72.
2003: Solaro R John
The special structure and function of troponin I in regulation of cardiac contraction and relaxation.
Advances in experimental medicine and biology 2003;538():389-401; discussion 401-2.
2002: Pieples Kathy; Arteaga Grace; Solaro R John; Grupp Ingrid; Lorenz John N; Boivin Greg P; Jagatheesan Ganapathy; Labitzke Erin; DeTombe Pieter P; Konhilas John P; Irving Thomas C; Wieczorek David F
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1344-53.
2002: Solaro R John; Montgomery David M; Wang Lynn; Burkart Eileen M; Ke Yunbo; Vahebi Susan; Buttrick Peter
Integration of pathways that signal cardiac growth with modulation of myofilament activity.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2002;9(5):523-33.
2002: Pyle W Glen; Sumandea Marius P; Solaro R John; De Tombe Pieter P
Troponin I serines 43/45 and regulation of cardiac myofilament function.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H1215-24.
2002: Martin Anne F; Phillips Ronald M; Kumar Ajit; Crawford Kelly; Abbas Zainab; Lessard James L; de Tombe Pieter; Solaro R John
Ca(2+) activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric gamma-actin.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H642-9.
2002: Li Xiuju; Misik Angelika J; Rieder Carmen V; Solaro R John; Lowen Anice; Fliegel Larry
Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1).
The Journal of biological chemistry 2002;277(32):28656-62.
2002: Pyle W Glen; Hart Marilyn C; Cooper John A; Sumandea Marius P; de Tombe Pieter P; Solaro R John
Actin capping protein: an essential element in protein kinase signaling to the myofilaments.
Circulation research 2002;90(12):1299-306.
2002: Montgomery David E; Wolska Beata M; Pyle W Glen; Roman Brian B; Dowell Jasmine C; Buttrick Peter M; Koretsky Alan P; Del Nido Pedro; Solaro R John
alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2397-405.
2002: Wolska Beata M; Arteaga Grace M; Peña James R; Nowak Grzegorz; Phillips Ronald M; Sahai Shalini; de Tombe Pieter P; Martin Anne F; Kranias Evangelia G; Solaro R John
Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation.
Circulation research 2002;90(8):882-8.
2002: Communal Catherine; Sumandea Marius; de Tombe Pieter; Narula Jagat; Solaro R John; Hajjar Roger J
Functional consequences of caspase activation in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6252-6.
2002: Solaro R John; Varghese Jamie; Marian A J; Chandra Murali
Molecular mechanisms of cardiac myofilament activation: modulation by pH and a troponin T mutant R92Q.
Basic research in cardiology 2002;97 Suppl 1():I102-10.
2002: Arteaga Grace M; Kobayashi Tomoyoshi; Solaro R John
Molecular actions of drugs that sensitize cardiac myofilaments to Ca2+.
Annals of medicine 2002;34(4):248-58.
2001: Wolska B M; Vijayan K; Arteaga G M; Konhilas J P; Phillips R M; Kim R; Naya T; Leiden J M; Martin A F; de Tombe P P; Solaro R J
Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions.
The Journal of physiology 2001;536(Pt 3):863-70.
2001: Wang X; Li M X; Spyracopoulos L; Beier N; Chandra M; Solaro R J; Sykes B D
Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.
The Journal of biological chemistry 2001;276(27):25456-66.
2001: Kentish J C; McCloskey D T; Layland J; Palmer S; Leiden J M; Martin A F; Solaro R J
Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle.
Circulation research 2001;88(10):1059-65.
2001: Huang L; Wolska B M; Montgomery D E; Burkart E M; Buttrick P M; Solaro R J
Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta.
American journal of physiology. Cell physiology 2001;280(5):C1114-20.
2001: Montgomery D E; Chandra M; Huang Q; Jin J; Solaro R J
Transgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of force.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1011-8.
2001: Chandra M; Rundell V L; Tardiff J C; Leinwand L A; De Tombe P P; Solaro R J
Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H705-13.
2000: Evans C C; Pena J R; Phillips R M; Muthuchamy M; Wieczorek D F; Solaro R J; Wolska B M
Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2000;279(5):H2414-23.
2000: de Tombe P P; Solaro R J
Integration of cardiac myofilament activity and regulation with pathways signaling hypertrophy and failure.
Annals of biomedical engineering 2000;28(8):991-1001.
2000: Arteaga G M; Palmiter K A; Leiden J M; Solaro R J
Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I.
The Journal of physiology 2000;526 Pt 3():541-9.
2000: Abbott M B; Gaponenko V; Abusamhadneh E; Finley N; Li G; Dvoretsky A; Rance M; Solaro R J; Rosevear P R
Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I.
The Journal of biological chemistry 2000;275(27):20610-7.
1999: Meehan J; Piano M R; Solaro R J; Kennedy J M
Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat.
Basic research in cardiology 1999;94(6):481-8.
1999: Solaro R J
Integration of myofilament response to Ca2+ with cardiac pump regulation and pump dynamics.
The American journal of physiology 1999;277(6 Pt 2):S155-63.
1999: Schwertz D W; Vizgirda V; Solaro R J; Piano M R; Ryjewski C
Sexual dimorphism in rat left atrial function and response to adrenergic stimulation.
Molecular and cellular biochemistry 1999;200(1-2):143-53.
1999: Chandra M; Kim J J; Solaro R J
An improved method for exchanging troponin subunits in detergent skinned rat cardiac fiber bundles.
Biochemical and biophysical research communications 1999;263(1):219-23.
1999: Muthuchamy M; Pieples K; Rethinasamy P; Hoit B; Grupp I L; Boivin G P; Wolska B; Evans C; Solaro R J; Wieczorek D F
Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.
Circulation research 1999;85(1):47-56.
1999: Finley N; Abbott M B; Abusamhadneh E; Gaponenko V; Dong W; Gasmi-Seabrook G; Howarth J W; Rance M; Solaro R J; Cheung H C; Rosevear P R
NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation.
FEBS letters 1999;453(1-2):107-12.
1999: Gasmi-Seabrook G M; Howarth J W; Finley N; Abusamhadneh E; Gaponenko V; Brito R M; Solaro R J; Rosevear P R
Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I.
Biochemistry 1999;38(26):8313-22.
1999: Gaponenko V; Abusamhadneh E; Abbott M B; Finley N; Gasmi-Seabrook G; Solaro R J; Rance M; Rosevear P R
Effects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C.
The Journal of biological chemistry 1999;274(24):16681-4.
1999: Fentzke R C; Buck S H; Patel J R; Lin H; Wolska B M; Stojanovic M O; Martin A F; Solaro R J; Moss R L; Leiden J M
Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart.
The Journal of physiology 1999;517 ( Pt 1)():143-57.
1999: Chandra M; Montgomery D E; Kim J J; Solaro R J
The N-terminal region of troponin T is essential for the maximal activation of rat cardiac myofilaments.
Journal of molecular and cellular cardiology 1999;31(4):867-80.
1999: Wolska B M; Keller R S; Evans C C; Palmiter K A; Phillips R M; Muthuchamy M; Oehlenschlager J; Wieczorek D F; de Tombe P P; Solaro R J
Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin.
Circulation research 1999;84(7):745-51.
1999: Rarick H M; Tang H P; Guo X D; Martin A F; Solaro R J
Interactions at the NH2-terminal interface of cardiac troponin I modulate myofilament activation.
Journal of molecular and cellular cardiology 1999;31(2):363-75.
1999: Piano M R; Rosenblum C; Solaro R J; Schwertz D
Calcium sensitivity and the effect of the calcium sensitizing drug pimobendan in the alcoholic isolated rat atrium.
Journal of cardiovascular pharmacology 1999;33(2):237-42.
1998: Powers F M; Fogelson B; Sturgeon C; Solaro R J; Law W R
Depressed myofilament co-operativity associated with post-cardioplegic myocardial depression.
Journal of molecular and cellular cardiology 1998;30(9):1779-87.
1998: Solaro R J; Rarick H M
Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments.
Circulation research 1998;83(5):471-80.
1998: Powers F M; Farias S; Minami H; Martin A F; Solaro R J; Law W R
Cardiac myofilament protein function is altered during sepsis.
Journal of molecular and cellular cardiology 1998;30(5):967-78.
1998: Van Eyk J E; Powers F; Law W; Larue C; Hodges R S; Solaro R J
Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation.
Circulation research 1998;82(2):261-71.
1998: Rethinasamy P; Muthuchamy M; Hewett T; Boivin G; Wolska B M; Evans C; Solaro R J; Wieczorek D F
Molecular and physiological effects of alpha-tropomyosin ablation in the mouse.
Circulation research 1998;82(1):116-23.
1997: Fraker L D; Van Eyk J; Solaro R J
Reversal of phosphate induced decreases in force by the benzimidazole pyridazinone, UD-CG 212 CL, in myofilaments from human ventricle.
Molecular and cellular biochemistry 1997;176(1-2):83-8.
1997: Li M X; Gagné S M; Spyracopoulos L; Kloks C P; Audette G; Chandra M; Solaro R J; Smillie L B; Sykes B D
NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changes.
Biochemistry 1997;36(41):12519-25.
1997: Wolska B M; Averyhart-Fullard V; Omachi A; Stojanovic M O; Kallen R G; Solaro R J
Changes in thyroid state affect pHi and Nai+ homeostasis in rat ventricular myocytes.
Journal of molecular and cellular cardiology 1997;29(10):2653-63.
1997: Chandra M; Dong W J; Pan B S; Cheung H C; Solaro R J
Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C.
Biochemistry 1997;36(43):13305-11.
1997: Rarick H M; Tu X H; Solaro R J; Martin A F
The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils.
The Journal of biological chemistry 1997;272(43):26887-92.
1997: Spyracopoulos L; Li M X; Sia S K; Gagné S M; Chandra M; Solaro R J; Sykes B D
Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.
Biochemistry 1997;36(40):12138-46.
1997: Palmiter K A; Solaro R J
Molecular mechanisms regulating the myofilament response to Ca2+: implications of mutations causal for familial hypertrophic cardiomyopathy.
Basic research in cardiology 1997;92 Suppl 1():63-74.
1996: Noland T A; Raynor R L; Jideama N M; Guo X; Kazanietz M G; Blumberg P M; Solaro R J; Kuo J F
Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants.
Biochemistry 1996;35(47):14923-31.
1996: Rarick H M; Opgenorth T J; von Geldern T W; Wu-Wong J R; Solaro R J
An essential myosin light chain peptide induces supramaximal stimulation of cardiac myofibrillar ATPase activity.
The Journal of biological chemistry 1996;271(43):27039-43.
1996: Wolska B M; Solaro R J
Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry.
The American journal of physiology 1996;271(3 Pt 2):H1250-5.
1996: Powers F M; Palmiter K A; Solaro R J
E-1020, a water soluble imidazopyridine, has direct effects on Ca(2+)-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments.
Molecular and cellular biochemistry 1996;160-161():33-9.
1996: Wolska B M; Stojanovic M O; Luo W; Kranias E G; Solaro R J
Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca2+.
The American journal of physiology 1996;271(1 Pt 1):C391-7.
1996: Wernberg G; Gentry J M; Solaro R J
Association of Chairmen of Departments of Physiology 1995 survey results.
The Physiologist 1996;39(3):83-9.
1996: Palmiter K A; Kitada Y; Muthuchamy M; Wieczorek D F; Solaro R J
Exchange of beta- for alpha-tropomyosin in hearts of transgenic mice induces changes in thin filament response to Ca2+, strong cross-bridge binding, and protein phosphorylation.
The Journal of biological chemistry 1996;271(20):11611-4.
1996: Luo W; Wolska B M; Grupp I L; Harrer J M; Haghighi K; Ferguson D G; Slack J P; Grupp G; Doetschman T; Solaro R J; Kranias E G
Phospholamban gene dosage effects in the mammalian heart.
Circulation research 1996;78(5):839-47.
1996: Solaro R J; Van Eyk J
Altered interactions among thin filament proteins modulate cardiac function.
Journal of molecular and cellular cardiology 1996;28(2):217-30.
1996: Wolska B M; Kitada Y; Palmiter K A; Westfall M V; Johnson M D; Solaro R J
CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction.
The American journal of physiology 1996;270(1 Pt 2):H24-32.
1995: Noland T A; Guo X; Raynor R L; Jideama N M; Averyhart-Fullard V; Solaro R J; Kuo J F
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1.
The Journal of biological chemistry 1995;270(43):25445-54.
1995: Kleerekoper Q; Howarth J W; Guo X; Solaro R J; Rosevear P R
Cardiac troponin I induced conformational changes in cardiac troponin C as monitored by NMR using site-directed spin and isotope labeling.
Biochemistry 1995;34(41):13343-52.
1995: Wattanapermpool J; Guo X; Solaro R J
The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar activity only when it is phosphorylated.
Journal of molecular and cellular cardiology 1995;27(7):1383-91.
1995: Powers F M; Solaro R J
Caffeine alters cardiac myofilament activity and regulation independently of Ca2+ binding to troponin C.
The American journal of physiology 1995;268(6 Pt 1):C1348-53.
1995: Wattanapermpool J; Reiser P J; Solaro R J
Troponin I isoforms and differential effects of acidic pH on soleus and cardiac myofilaments.
The American journal of physiology 1995;268(2 Pt 1):C323-30.
1995: Gao L; Kennedy J M; Solaro R J
Differential expression of TnI and TnT isoforms in rabbit heart during the perinatal period and during cardiovascular stress.
Journal of molecular and cellular cardiology 1995;27(1):541-50.
1995: Solaro R J
Troponin C - troponin I interactions and molecular signalling in cardiac myofilaments.
Advances in experimental medicine and biology 1995;382():109-15.
1994: Reiser P J; Westfall M V; Schiaffino S; Solaro R J
Tension production and thin-filament protein isoforms in developing rat myocardium.
The American journal of physiology 1994;267(4 Pt 2):H1589-96.
1994: Krudy G A; Kleerekoper Q; Guo X; Howarth J W; Solaro R J; Rosevear P R
NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex.
The Journal of biological chemistry 1994;269(38):23731-5.
1994: Ball K L; Johnson M D; Solaro R J
Isoform specific interactions of troponin I and troponin C determine pH sensitivity of myofibrillar Ca2+ activation.
Biochemistry 1994;33(28):8464-71.
1994: Guo X; Wattanapermpool J; Palmiter K A; Murphy A M; Solaro R J
Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation.
The Journal of biological chemistry 1994;269(21):15210-6.
1994: Averyhart-Fullard V; Fraker L D; Murphy A M; Solaro R J
Differential regulation of slow-skeletal and cardiac troponin I mRNA during development and by thyroid hormone in rat heart.
Journal of molecular and cellular cardiology 1994;26(5):609-16.
1994: Ball K L; Solaro R J
Discoordinate regulation of contractile protein gene expression in the senescent rat myocardium.
Journal of molecular and cellular cardiology 1994;26(4):519-25.
1993: Solaro R J; Gambassi G; Warshaw D M; Keller M R; Spurgeon H A; Beier N; Lakatta E G
Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments.
Circulation research 1993;73(6):981-90.
1993: Westfall M V; Wahler G M; Solaro R J
A highly specific benzimidazole pyridazinone reverses phosphate-induced changes in cardiac myofilament activation.
Biochemistry 1993;32(39):10464-70.
1993: Kawamura A; Wahler G M; Solaro R J
RWJ-24517, a positive inotropic agent, has novel effects on action potentials in guinea pig myocardium.
Journal of cardiovascular pharmacology 1993;22(4):519-25.
1992: Westfall M V; Solaro R J
Alterations in myofibrillar function and protein profiles after complete global ischemia in rat hearts.
Circulation research 1992;70(2):302-13.
1992: Westfall M V; Wahler G M; Fujino K; Solaro R J
Electrophysiological actions of the pimobendan metabolite, UD-CG 212 Cl, in guinea pig myocardium.
The Journal of pharmacology and experimental therapeutics 1992;260(1):58-63.
1991: Martin A F; Ball K; Gao L Z; Kumar P; Solaro R J
Identification and functional significance of troponin I isoforms in neonatal rat heart myofibrils.
Circulation research 1991;69(5):1244-52.
1991: Solaro R J
Regulation of Ca(2+)-signaling in cardiac myofilaments.
Medicine and science in sports and exercise 1991;23(10):1145-8.
1990: Pan B S; Palmiter K A; Plonczynski M; Solaro R J
Slowly exchanging calcium binding sites unique to cardiac/slow muscle troponin C.
Journal of molecular and cellular cardiology 1990;22(10):1117-24.
1990: Dieckman L J; Solaro R J
Effect of thyroid status on thin-filament Ca2+ regulation and expression of troponin I in perinatal and adult rat hearts.
Circulation research 1990;67(2):344-51.
1990: Murphy A M; Solaro R J
Developmental difference in the stimulation of cardiac myofibrillar Mg2(+)-ATPase activity by calmidazolium.
Pediatric research 1990;28(1):46-9.
1990: McAuliffe J J; Gao L Z; Solaro R J
Changes in myofibrillar activation and troponin C Ca2+ binding associated with troponin T isoform switching in developing rabbit heart.
Circulation research 1990;66(5):1204-16.
1989: Edes I; Solaro R J; Kranias E G
Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol.
Circulation research 1989;65(4):989-96.
1989: Solaro R J; el-Saleh S C; Kentish J C
Ca2+, pH and the regulation of cardiac myofilament force and ATPase activity.
Molecular and cellular biochemistry 1989;89(2):163-7.
1989: Rapundalo S T; Solaro R J; Kranias E G
Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins.
Circulation research 1989;64(1):104-11.
1989: Solaro R J; el-Saleh S C; Kentish J; Meyer A; Martin A
Transitions in isoform populations of thick and thin filament proteins and calcium activation of force and ATP hydrolysis by cardiac myofilaments.
Progress in clinical and biological research 1989;315():487-502.
1989: Solaro R J; Fujino K; Sperelakis N
The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments.
Journal of cardiovascular pharmacology 1989;14 Suppl 2():S7-12.
1988: Fujino K; Sperelakis N; Solaro R J
Differential effects of d- and l-pimobendan on cardiac myofilament calcium sensitivity.
The Journal of pharmacology and experimental therapeutics 1988;247(2):519-23.
1988: Fujino K; Sperelakis N; Solaro R J
Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone.
Circulation research 1988;63(5):911-22.
1988: Jakab G; Rapundalo S T; Solaro R J; Kranias E G
Phosphorylation of phospholipids in isolated guinea pig hearts stimulated with isoprenaline.
The Biochemical journal 1988;251(1):189-94.
1988: el-Saleh S C; Solaro R J
Troponin I enhances acidic pH-induced depression of Ca2+ binding to the regulatory sites in skeletal troponin C.
The Journal of biological chemistry 1988;263(7):3274-8.
1988: Garvey J L; Kranias E G; Solaro R J
Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts.
The Biochemical journal 1988;249(3):709-14.
1987: el-Saleh S C; Solaro R J
Calmidazolium, a calmodulin antagonist, stimulates calcium-troponin C and calcium-calmodulin-dependent activation of striated muscle myofilaments.
The Journal of biological chemistry 1987;262(35):17240-6.
1985: Kranias E G; Garvey J L; Srivastava R D; Solaro R J
Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline.
The Biochemical journal 1985;226(1):113-21.

Sign-in to see more