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John Solaro

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Anatomy

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Myocardial Contraction

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Benjamin R Nixon; Ozgur Ogut; Nicoletta Piroddi; Corrado Poggesi; Beatrice Scellini; R John Solaro; Chiara Tesi; Mark T Ziolo; Jonathan P Davis; Paul M L Janssen; Bin Liu; Brandon J Biesiadecki
Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.
Michelle M Monasky; R John Solaro; Domenico M Taglieri; Kaylan M Haizlip; Alice K Jacobson; Paul M L Janssen
Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium.
Raghu S Nagalingam; R John Solaro; Nagalingam R Sundaresan; David L Geenen; Mahesh P Gupta; Madhu Gupta
A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.

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2013: Benjamin R Nixon; Ozgur Ogut; Nicoletta Piroddi; Corrado Poggesi; Beatrice Scellini; R John Solaro; Chiara Tesi; Mark T Ziolo; Jonathan P Davis; Paul M L Janssen; Bin Liu; Brandon J Biesiadecki
Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.
Archives of biochemistry and biophysics 2013;535(1):30-8.
2013: Michelle M Monasky; R John Solaro; Domenico M Taglieri; Kaylan M Haizlip; Alice K Jacobson; Paul M L Janssen
Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium.
Archives of biochemistry and biophysics 2013;535(1):22-9.
2013: Raghu S Nagalingam; R John Solaro; Nagalingam R Sundaresan; David L Geenen; Mahesh P Gupta; Madhu Gupta
A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.
The Journal of biological chemistry 2013;288(16):11216-32.
2013: Marcus Henze; Aaron Hinken; Minae Kobayashi; Tomoyoshi Kobayashi; Stacey E Patrick; Peipei Ping; Sarah B Scruggs; Pieter P de Tombe; Paul H Goldspink; R John Solaro
New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I.
Biochimica et biophysica acta 2013;1833(4):823-32.
2013: Euy-Myoung Jeong; Hong Liu; Michelle M Monasky; Bindiya G Patel; Samuel C Dudley; Ian Greener; Lianzhi Gu; Domenico M Taglieri; Qiongying Wang; R John Solaro
Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties.
Journal of molecular and cellular cardiology 2013;56():44-54.
2013: R John Solaro; Marcus Henze; Tomoyoshi Kobayashi
Integration of troponin I phosphorylation with cardiac regulatory networks.
Circulation research 2013;112(2):355-66.
2012: Emily M Schulz; Hajer N Sheikh; R John Solaro; Richard N Correll; Patti L Engel; Marco S Lofrano-Alves; Jeffery D Molkentin; Gilbert Newman; Jo El J Schultz; Beata M Wolska; David F Wieczorek
Tropomyosin dephosphorylation results in compensated cardiac hypertrophy.
The Journal of biological chemistry 2012;287(53):44478-89.
2012: R John Solaro; Mrinalini C Rao
Kate Bárány: a life of science, teaching, and service.
Journal of muscle research and cell motility 2012;33(6):369-71.
2012: Aaron C Hinken; Laurin M Hanft; Jeffery Robbins; Sakthivel Sadayappan; Sarah B Scruggs; R John Solaro; Kerry S McDonald
Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.
Journal of muscle research and cell motility 2012;33(6):439-48.
2012: Hsiao-Lei Lai; Andrea L McGinley; R John Solaro; Shamim A K Chowdhury; David L Geenen; Milana Grachoff; Farida F Khan; Chad M Warren; Beata M Wolska; Qun-Tian T Wang
Maintenance of adult cardiac function requires the chromatin factor Asxl2.
Journal of molecular and cellular cardiology 2012;53(5):734-41.
2012: Benjamin R Nixon; R John Solaro; Ariyoporn Thawornkaiwong; Elizabeth A Brundage; Jonathan P Davis; Janel Jin; Sean C Little; Brandon J Biesiadecki
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
The Journal of biological chemistry 2012;287(23):19136-47.
2012: Ivana Knezevic; Raghu Sundaresan Nagalingam; Aalok Patel; R John Solaro; Nagalingam R Sundaresan; Mahesh P Gupta; Madhu Gupta
A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival.
The Journal of biological chemistry 2012;287(16):12913-26.
2012: Joshua D Lovelock; Michelle M Monasky; Bindiya G Patel; Narayan Pokhrel; R John Solaro; Dan Sorescu; Domenico M Taglieri; Dewan Zeng; Lianzhi Gu; Euy-Myoung Jeong; Praveen Kumar; Harvey A Lardin; Hong Liu; Luiz Belardinelli; Samuel C Dudley
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity.
Circulation research 2012;110(6):841-50.
2012: Michelle M Monasky; Beata M Wolska; Domenico M Taglieri; Bindiya G Patel; Yunbo Ke; Jonathan Chernoff; R John Solaro
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation.
American journal of physiology. Heart and circulatory physiology 2012;302(1):H224-30.
2011: Wei Liu; Susanne Ulm; Sukhpal Prehar; Ronald Naumann; Yunbo Ke; Rui-Ping Xiao; Jiawei Jin; Ludwig Neyses; Junhong Gui; Min Zi; Elizabeth J Cartwright; Hoyee Tsui; Domenico M Taglieri; R John Solaro; Ming Lei; Xin Wang
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Circulation 2011;124(24):2702-15.
2011: Domenico M Taglieri; Xin Wang; Beata M Wolska; Jonathan Chernoff; Yunbo Ke; Ivana Knezevic; Ming Lei; Michelle M Monasky; Katherine Sheehan; R John Solaro
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.
Journal of molecular and cellular cardiology 2011;51(6):988-96.
2011: Rashad J Belin; David L Geenen; Laura A Harvey; Gail A Sievert; R John Solaro; Marius P Sumandea; Pieter P de Tombe
Interventricular differences in myofilament function in experimental congestive heart failure.
Pflügers Archiv : European journal of physiology 2011;462(6):795-809.
2011: Xun Ai; Aiyang Jiang; Yunbo Ke; R John Solaro; Steven M Pogwizd
Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43.
Cardiovascular research 2011;92(1):106-14.
2011: Emmanuel Eroume A Egom; Farzin Fath-Ordoubadi; Yunbo Ke; Elizabeth J Cartwright; Sanoj Chacko; Debora Chirico; Wei Liu; Mamas A Mamas; Tamer M A Mohamed; Mohamed Shaheen; Ying Shi; R John Solaro; Sally E Stringer; Tao Wang; Xin Wang; Ming Lei
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1487-95.
2011: Kayla M Pound; R John Solaro; Chad M Warren; Adam R Wende; Tanganyika Wilder; E Dale Abel; Grace M Arteaga; Mariam Farjah; Mathew Fasano; Susan K Fischer; E Douglas Lewandowski
Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia.
Journal of molecular and cellular cardiology 2011;51(2):236-43.
2011: Sarah B Scruggs; R John Solaro
The significance of regulatory light chain phosphorylation in cardiac physiology.
Archives of biochemistry and biophysics 2011;510(2):129-34.
2011: R John Solaro; Tomoyoshi Kobayashi
Protein phosphorylation and signal transduction in cardiac thin filaments.
The Journal of biological chemistry 2011;286(12):9935-40.
2011: R John Solaro; James T Stull
Thematic minireview series on signaling in cardiac sarcomeres in health and disease.
The Journal of biological chemistry 2011;286(12):9895.
2011: Chehade N Karam; Chad M Warren; Sudarsan Rajan; Pieter P de Tombe; David F Wieczorek; R John Solaro
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
Journal of muscle research and cell motility 2011;31(5-6):315-22.
2011: Katherine Sheehan; Grace M Arteaga; Aaron C Hinken; Fernando A Dias; Cibele Ribeiro; David F Wieczorek; R John Solaro; Beata M Wolska
Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis.
Journal of molecular and cellular cardiology 2011;50(3):442-50.
2011: Krystyna Malinowska Shioura; Mariam Farjah; David L Geenen; R John Solaro; Paul H Goldspink
Myofilament calcium sensitization delays decompensated hypertrophy differently between the sexes following myocardial infarction.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(2):R361-8.
2010: James R Peña; Ariani C Szkudlarek; Chad M Warren; Lynley S Heinrich; Robert Gaffin; Ganapathy Jagatheesan; Federica del Monte; Roger J Hajjar; Paul H Goldspink; R John Solaro; David F Wieczorek; Beata M Wolska
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2010;49(6):993-1002.
2010: Thomas Force; Robert O Bonow; Steven R Houser; R John Solaro; Ray E Hershberger; Bishow Adhikari; Mark E Anderson; Robin Boineau; Barry J Byrne; Thomas P Cappola; Raghu Kalluri; Martin M LeWinter; Martin S Maron; Jeffery D Molkentin; Steve R Ommen; Michael Regnier; W H Wilson Tang; Rong Tian; Marvin A Konstam; Barry J Maron; Christine E Seidman
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.
Circulation 2010;122(11):1130-3.
2010: Ganapathy Jagatheesan; Sudarsan Rajan; Rafeeq P H Ahmed; Natalia N Petrashevskaya; Greg Boivin; Grace M Arteaga; Hyun-Jin Tae; Stephen B Liggett; R John Solaro; David F Wieczorek
Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.
Journal of muscle research and cell motility 2010;31(3):227-39.
2010: Benjamin S Avner; Aaron C Hinken; Chao Yuan; R John Solaro
H2O2 alters rat cardiac sarcomere function and protein phosphorylation through redox signaling.
American journal of physiology. Heart and circulatory physiology 2010;299(3):H723-30.
2010: Sarah B Scruggs; Rick Reisdorph; Mike L Armstrong; Chad M Warren; Nichole Reisdorph; R John Solaro; Peter M Buttrick
A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain.
Molecular & cellular proteomics : MCP 2010;9(9):1804-18.
2010: Emmanuel Eroume A Egom; Yunbo Ke; R John Solaro; Ming Lei
Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.
Progress in biophysics and molecular biology 2010;103(1):142-7.
2010: R John Solaro; Katherine Sheehan; Ming Lei; Yunbo Ke
The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes.
The Journal of general physiology 2010;136(1):13-9.
2010: Brandon J Biesiadecki; Kittipong Tachampa; Chao Yuan; J-P Jin; Pieter P de Tombe; R John Solaro
Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice.
The Journal of biological chemistry 2010;285(25):19688-98.
2010: Chad M Warren; David L Geenen; Donald L Helseth; Hua Xu; R John Solaro
Sub-proteomic fractionation, iTRAQ, and OFFGEL-LC-MS/MS approaches to cardiac proteomics.
Journal of proteomics 2010;73(8):1551-61.
2010: R John Solaro; Chad M Warren; Sarah B Scruggs
Why is it important to analyze the cardiac sarcomere subproteome?
Expert review of proteomics 2010;7(3):311-4.
2010: R John Solaro; Jolanda van der Velden
Why does troponin I have so many phosphorylation sites? Fact and fancy.
Journal of molecular and cellular cardiology 2010;48(5):810-6.
2010: R John Solaro
The activity of cardiac myocytes reflects a confluence of a multitude of electrical and chemical signals that promote and control the ability of the myocytes to shorten and develop force.
Journal of molecular and cellular cardiology 2010;48(5):809.
2010: Dong I Lee; Susan Vahebi; Carlo Gabriele Tocchetti; Lili A Barouch; R John Solaro; Eiki Takimoto; David A Kass
PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation.
Basic research in cardiology 2010;105(3):337-47.
2010: Qun-Wei Lu; Aaron C Hinken; Stacey E Patrick; R John Solaro; Tomoyoshi Kobayashi
Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.
The Journal of biological chemistry 2010;285(16):11810-7.
2010: Yunbo Ke; Katherine Sheehan; E Eroume A Egom; Ming Lei; R John Solaro
Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase.
American journal of physiology. Heart and circulatory physiology 2010;298(4):H1283-9.
2010: E Eroume A Egom; Yunbo Ke; Hassan Musa; Tamer M A Mohamed; Tao Wang; Elizabeth J Cartwright; R John Solaro; Ming Lei
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
Journal of molecular and cellular cardiology 2010;48(2):406-14.
2010: Sudarsan Rajan; Ganapathy Jagatheesan; Chehade N Karam; Marco L Alves; Ilona Bodi; Arnold Schwartz; Christian F Bulcao; Karen M D'Souza; Shahab A Akhter; Gregory P Boivin; Dipak K Dube; Natalia N Petrashevskaya; Andrew B Herr; Roger Hullin; Stephen B Liggett; Beata M Wolska; R John Solaro; David F Wieczorek
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
Circulation 2010;121(3):410-8.
2010: R John Solaro
Sarcomere control mechanisms and the dynamics of the cardiac cycle.
Journal of biomedicine & biotechnology 2010;2010():105648.
2009: Jonathan A Kirk; Guy A MacGowan; Caroline Evans; Stephen H Smith; Chad M Warren; Ranganath Mamidi; Murali Chandra; Alexandre Stewart; R John Solaro; Sanjeev G Shroff
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.
Circulation research 2009;105(12):1232-9.
2009: Patti L. Engel; Aaron Hinken; R John Solaro
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments.
Journal of molecular and cellular cardiology 2009;47(3):359-64.
2009: Ganapathy Jagatheesan; Sudarsan Rajan; Emily M Schulz; Rafeeq P H Ahmed; Natalia N Petrashevskaya; Arnold Schwartz; Gregory P Boivin; Grace M Arteaga; Tao Wang; Yi-Gang Wang; Muhammad Ashraf; Stephen B Liggett; John Lorenz; R John Solaro; David F Wieczorek
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H181-90.
2009: Chad M Warren; Tomoyoshi Kobayashi; R John Solaro
Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex.
The Journal of biological chemistry 2009;284(21):14258-66.
2009: Thomas J Hartman; Jody L Martin; R John Solaro; Allen M Samarel; Brenda Russell
CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms.
American journal of physiology. Cell physiology 2009;296(5):C1034-9.
2009: R John Solaro
CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease.
IDrugs : the investigational drugs journal 2009;12(4):243-51.
2009: Sherwin J Abraham; Tomoyoshi Kobayashi; R John Solaro; Vadim Gaponenko
Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins.
Journal of biomolecular NMR 2009;43(4):239-46.
2009: Sarah B Scruggs; Aaron C Hinken; Ariyaporn Thawornkaiwong; Jeffrey Robbins; Lori A Walker; Pieter P de Tombe; David L Geenen; Peter M Buttrick; R John Solaro
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.
The Journal of biological chemistry 2009;284(8):5097-106.
2009: R John Solaro
Maintaining cooperation among cardiac myofilament proteins through thick and thin.
The Journal of physiology 2009;587(Pt 1):3.
2009: Katherine Sheehan; Yunbo Ke; Beata M Wolska; R John Solaro
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes.
American journal of physiology. Cell physiology 2009;296(1):C47-58.
2008: Yunbo Ke; R John Solaro
Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation.
Biologics : targets & therapy 2008;2(4):903-9.
2008: Franz Baudenbacher; Tilmann Schober; Jose Renato Pinto; Veniamin Y Sidorov; Fredrick Hilliard; R John Solaro; James D Potter; Björn C Knollmann
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.
The Journal of clinical investigation 2008;118(12):3893-903.
2008: R John Solaro
Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins.
The Journal of biological chemistry 2008;283(40):26829-33.
2008: Yunbo Ke; Ming Lei; R John Solaro
Regulation of cardiac excitation and contraction by p21 activated kinase-1.
Progress in biophysics and molecular biology 2008;98(2-3):238-50.
2008: Yoram Rudy; Michael J Ackerman; Donald M Bers; colleen clancy; Steven R Houser; Barry London; Andrew D McCulloch; DA Przywara; Randall L Rasmusson; R John Solaro; Natalia A Trayanova; David Van Wagoner; András Varró; James N Weiss; David Austin Lathrop
Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.
Circulation 2008;118(11):1202-11.
2008: Marius P Sumandea; Vitalyi O Rybin; Aaron C Hinken; Chaojian Wang; Tomoyoshi Kobayashi; Erin Harleton; Gail A Sievert; C William Balke; Steven J Feinmark; R John Solaro; Susan F Steinberg
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
The Journal of biological chemistry 2008;283(33):22680-9.
2008: Chao Yuan; Quanhu SHENG; Haixu Tang; Yixue Li; Rong Zeng; R John Solaro
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.
American journal of physiology. Heart and circulatory physiology 2008;295(2):H647-56.
2008: Chao Yuan; R John Solaro
Myofilament proteins: From cardiac disorders to proteomic changes.
Proteomics. Clinical applications 2008;2(6):788-99.
2008: Kittipong Tachampa; Tomoyoshi Kobayashi; Helen Wang; Anne F Martin; Brandon J Biesiadecki; R John Solaro; Pieter P de Tombe
Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle.
The Journal of biological chemistry 2008;283(22):15114-21.
2008: R John Solaro; Paul Rosevear; Tomoyoshi Kobayashi
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation.
Biochemical and biophysical research communications 2008;369(1):82-7.
2008: R John Solaro; Pieter P de Tombe
Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function.
Cardiovascular research 2008;77(4):616-8.
2008: Hiroaki Minami; Beata M Wolska; Miroslav O Stojanovic; R John Solaro
Reversal of effects of acidosis on contraction of rat heart myocytes by CGP-48506.
Frontiers in bioscience : a journal and virtual library 2008;13():5638-45.
2008: Chad M Warren; Grace M Arteaga; Sudarsan Rajan; Rafeeq Ahmed; David F Wieczorek; R John Solaro
Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.
Proteomics 2008;8(1):100-5.
2007: R John Solaro
Mechanisms of the Frank-Starling law of the heart: the beat goes on.
Biophysical journal 2007;93(12):4095-6.
2007: Jack W Howarth; Jaroslaw Meller; R John Solaro; Jill Trewhella; Paul R Rosevear
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin.
Journal of molecular biology 2007;373(3):706-22.
2007: Steven C Wu; R John Solaro
Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins.
The Journal of biological chemistry 2007;282(42):30691-8.
2007: Ming Lei; Yunbo Ke; R John Solaro
Pak1: steps towards understanding the regulatory mechanisms of pacemaker function of the heart.
Future cardiology 2007;3(5):473-6.
2007: Katherine Sheehan; Yunbo Ke; R John Solaro
p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R963-73.
2007: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Grace M Arteaga; R John Solaro; Stephen B Liggett; David F Wieczorek
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H949-58.
2007: R John Solaro
Translational medicine with a capital T, troponin T, that is.
Circulation research 2007;101(2):114-5.
2007: Rashad J Belin; Marius P Sumandea; Edward J Allen; Kelly Schoenfelt; Helen Wang; R John Solaro; Pieter P de Tombe
Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure.
Circulation research 2007;101(2):195-204.
2007: Sudarsan Rajan; Rafeeq Ahmed; Ganapathy Jagatheesan; Natalia N Petrashevskaya; Gregory P Boivin; Dalia Urboniene; Grace M Arteaga; Beata M Wolska; R John Solaro; Stephen B Liggett; David F Wieczorek
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Circulation research 2007;101(2):205-14.
2007: Lei Xiao; Qiong Zhao; Yanmei Du; Chao Yuan; R John Solaro; Peter M Buttrick
PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.
Biochemistry 2007;46(23):7054-61.
2007: Yunbo Ke; Ming Lei; Thomas P Collins; Stevan Rakovic; Paul A D Mattick; Michiko Yamasaki; Mark S Brodie; Derek A Terrar; R John Solaro
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells.
Circulation research 2007;100(9):1317-27.
2007: R John Solaro
Nitroxyl effects on myocardium provide new insights into the significance of altered myofilament response to calcium in the regulation of contractility.
The Journal of physiology 2007;580(Pt.3):697.
2007: Jonathan P Davis; Catalina Norman; Tomoyoshi Kobayashi; R John Solaro; Darl R Swartz; Svetlana B Tikunova
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C.
Biophysical journal 2007;92(9):3195-206.
2007: Aaron C Hinken; R John Solaro
A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation.
Physiology (Bethesda, Md.) 2007;22():73-80.
2007: Yunbo Ke; Hazel Lum; R John Solaro
Inhibition of endothelial barrier dysfunction by P21-activated kinase-1.
Canadian journal of physiology and pharmacology 2007;85(3-4):281-8.
2007: Susan Vahebi; Asuka Ota; Manxiang Li; Chad M Warren; Pieter P de Tombe; Yibin Wang; R John Solaro
p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
Circulation research 2007;100(3):408-15.
2007: Tepmanas Bupha-Intr; Jonggonnee Wattanapermpool; James R Peña; Beata M Wolska; R John Solaro
Myofilament response to Ca2+ and Na+/H+ exchanger activity in sex hormone-related protection of cardiac myocytes from deactivation in hypercapnic acidosis.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(2):R837-43.
2007: Patti L. Engel; Tomoyoshi Kobayashi; Brandon Biesiadecki; Jonathan Davis; Svetlana B Tikunova; Steven Wu; R John Solaro
Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.
The Journal of biological chemistry 2007;282(1):183-93.
2007: Grzegorz Nowak; James R Peña; Dalia Urboniene; David L Geenen; R John Solaro; Beata M Wolska
Correlations between alterations in length-dependent Ca2+ activation of cardiac myofilaments and the end-systolic pressure-volume relation.
Journal of muscle research and cell motility 2007;28(7-8):415-9.
2007: R John Solaro; Grace M Arteaga
Heart failure, ischemia/reperfusion injury and cardiac troponin.
Advances in experimental medicine and biology 2007;592():191-200.
2006: Rashad J Belin; Marius P Sumandea; Tomoyoshi Kobayashi; Lori A Walker; Veronica L M Rundell; Dalia Urboniene; Milana Yuzhakova; Stuart H Ruch; David L Geenen; R John Solaro; Pieter P de Tombe
Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2344-53.
2006: W Glen Pyle; Gustavo La Rotta; Pieter P de Tombe; Marius P Sumandea; R John Solaro
Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ.
Journal of molecular and cellular cardiology 2006;41(3):537-43.
2006: Shannon J McCall; Rashid Nassar; Nadia Anderson; Aleister J Saunders; Annette E Oakeley; Paul M Henderson; R John Solaro; Gary J Pielak; Kenneth A Alexander; Page A W Anderson
Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit.
Pediatric research 2006;60(3):276-81.
2006: Brandon J Biesiadecki; R John Solaro
When hearts fail so does skeletal muscle: breaking a vicious cycle.
Circulation research 2006;98(12):1456-8.
2006: Tomoyoshi Kobayashi; R John Solaro
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I.
The Journal of biological chemistry 2006;281(19):13471-7.
2006: Sarah B Scruggs; Lori A Walker; Theodore Lyu; David L Geenen; R John Solaro; Peter M Buttrick; Paul H Goldspink
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation.
Journal of molecular and cellular cardiology 2006;40(4):465-73.
2006: David A Kass; R John Solaro
Mechanisms and use of calcium-sensitizing agents in the failing heart.
Circulation 2006;113(2):305-15.
2005: Grace M Arteaga; Chad M Warren; Sanja Milutinovic; Anne F Martin; R John Solaro
Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction.
American journal of physiology. Heart and circulatory physiology 2005;289(5):H2183-92.
2005: Susan Vahebi; R John Solaro
Cardiac sarcomeric function, small G-protein signaling, and heart failure.
Panminerva medica 2005;47(3):133-42.
2005: Dalia Urboniene; Fernando A L Dias; James R Peña; Lori A Walker; R John Solaro; Beata M Wolska
Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia.
Circulation research 2005;97(1):70-7.
2005: Joanne Layland; Alison C Cave; Chad Warren; David J Grieve; Emma Sparks; Jonathan C Kentish; R John Solaro; Ajay M Shah
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1137-9.
2005: R John Solaro
Remote control of A-band cardiac thin filaments by the I-Z-I protein network of cardiac sarcomeres.
Trends in cardiovascular medicine 2005;15(4):148-52.
2005: Susan Vahebi; Tomoyoshi Kobayashi; Chad M Warren; Pieter P de Tombe; R John Solaro
Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin.
Circulation research 2005;96(7):740-7.
2005: Joanne Layland; R John Solaro; Ajay M Shah
Regulation of cardiac contractile function by troponin I phosphorylation.
Cardiovascular research 2005;66(1):12-21.
2005: Tomoyoshi Kobayashi; R John Solaro
Calcium, thin filaments, and the integrative biology of cardiac contractility.
Annual review of physiology 2005;67():39-67.
2005: Tomoyoshi Kobayashi; Xiaofeng Yang; Lori A Walker; Richard B Van Breemen; R John Solaro
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C.
Journal of molecular and cellular cardiology 2005;38(1):213-8.
2004: Aldrin Gomes; Gayathri Venkatraman; Jonathan P Davis; Svetlana B Tikunova; Patti L. Engel; R John Solaro; James D Potter
Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart.
The Journal of biological chemistry 2004;279(48):49579-87.
2004: Jeffrey A Towbin; R John Solaro
Genetics of dilated cardiomyopathy: more genes that kill.
Journal of the American College of Cardiology 2004;44(10):2041-3.
2004: Michael S Parmacek; R John Solaro
Biology of the troponin complex in cardiac myocytes.
Progress in cardiovascular diseases 2004;47(3):159-76.
2004: Tia Sorsa; Piero Pollesello; R John Solaro
The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.
Molecular and cellular biochemistry 2004;266(1-2):87-107.
2004: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Grace M Arteaga; Pieter P de Tombe; R John Solaro; David F Wieczorek
Physiological significance of troponin T binding domains in striated muscle tropomyosin.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1484-94.
2004: Paul H Goldspink; David E Montgomery; Lori A Walker; Dalia Urboniene; Ronald D McKinney; David L Geenen; R John Solaro; Peter M Buttrick
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.
Circulation research 2004;95(4):424-32.
2004: Brian B Roman; Paul H Goldspink; Elyse Spaite; Dalia Urboniene; Ronald D McKinney; David L Geenen; R John Solaro; Peter M Buttrick
Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo.
American journal of physiology. Heart and circulatory physiology 2004;286(6):H2089-95.
2004: Tomoyoshi Kobayashi; Wen-Ji Dong; Eileen M Burkart; Herbert C Cheung; R John Solaro
Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation.
Biochemistry 2004;43(20):5996-6004.
2004: Marius P Sumandea; Eileen M Burkart; Tomoyoshi Kobayashi; Pieter P de Tombe; R John Solaro
Molecular and integrated biology of thin filament protein phosphorylation in heart muscle.
Annals of the New York Academy of Sciences 2004;1015():39-52.
2004: Joanne Layland; David J Grieve; Alison C Cave; Emma Sparks; R John Solaro; Ajay M Shah
Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically.
The Journal of physiology 2004;556(Pt 3):835-47.
2004: Xiaofeng Yang; Huaping Wu; Tomoyoshi Kobayashi; R John Solaro; Richard B Van Breemen
Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry.
Analytical chemistry 2004;76(5):1532-6.
2004: W Glen Pyle; R John Solaro
At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function.
Circulation research 2004;94(3):296-305.
2004: Yunbo Ke; Lynn Wang; W Glen Pyle; Pieter P de Tombe; R John Solaro
Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes.
Circulation research 2004;94(2):194-200.
2004: David Wayne Maughan; David M Warshaw; Norman Alpert; Martin M LeWinter; R John Solaro; Christian Holubarsch; Kazuhiro Yamada
Conference report: fifth international conference on muscle energetics, July 2001.
Journal of muscle research and cell motility 2004;25(8):667-70.
2003: Eileen M Burkart; Grace M Arteaga; Marius P Sumandea; Rethinasamy Prabhakar; David F Wieczorek; R John Solaro
Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 2003;35(10):1285-93.
2003: Marius P Sumandea; W Glen Pyle; Tomoyoshi Kobayashi; Pieter P de Tombe; R John Solaro
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T.
The Journal of biological chemistry 2003;278(37):35135-44.
2003: Ganapathy Jagatheesan; Sudarsan Rajan; Natalia N Petrashevskaya; Arnold Schwartz; Greg Boivin; Susan Vahebi; Pieter DeTombe; R John Solaro; Erin Hall (Maiden: Labitzke); George M Hilliard; David F Wieczorek
Functional importance of the carboxyl-terminal region of striated muscle tropomyosin.
The Journal of biological chemistry 2003;278(25):23204-11.
2003: Eileen M Burkart; Marius P Sumandea; Tomoyoshi Kobayashi; Mahta Nili; Anne F Martin; Earl Homsher; R John Solaro
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity.
The Journal of biological chemistry 2003;278(13):11265-72.
2003: John P Konhilas; Thomas C Irving; Beata M Wolska; Eias Jweied; Anne F Martin; R John Solaro; Pieter P de Tombe
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.
The Journal of physiology 2003;547(Pt 3):951-61.
2003: R John Solaro
The special structure and function of troponin I in regulation of cardiac contraction and relaxation.
Advances in experimental medicine and biology 2003;538():389-401; discussion 401-2.
2002: Kathy Pieples; Grace M Arteaga; R John Solaro; Ingrid L Grupp; John N Lorenz; Gregory P Boivin; Ganapathy Jagatheesan; Erin Hall (Maiden: Labitzke); Pieter DeTombe; John P Konhilas; Thomas C Irving; David F Wieczorek
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1344-53.
2002: R John Solaro; David M Montgomery; Lynn Wang; Eileen M Burkart; Yunbo Ke; Susan Vahebi; Peter M Buttrick
Integration of pathways that signal cardiac growth with modulation of myofilament activity.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2002;9(5):523-33.
2002: W Glen Pyle; Marius P Sumandea; R John Solaro; Pieter P de Tombe
Troponin I serines 43/45 and regulation of cardiac myofilament function.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H1215-24.
2002: Xiuju Li; Angelika J Misik; Carmen V Rieder; R John Solaro; Anice Lowen; Larry Fliegel
Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1).
The Journal of biological chemistry 2002;277(32):28656-62.
2002: Anne F Martin; Ronald M Phillips; Ajit Kumar; Kelly Crawford; Zainab Abbas; James L Lessard; Pieter P de Tombe; R John Solaro
Ca(2+) activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric gamma-actin.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H642-9.
2002: W Glen Pyle; Marilyn C Hart; John A Cooper; Marius P Sumandea; Pieter P de Tombe; R John Solaro
Actin capping protein: an essential element in protein kinase signaling to the myofilaments.
Circulation research 2002;90(12):1299-306.
2002: David E Montgomery; Beata M Wolska; W Glen Pyle; Brian B Roman; Jasmine C Dowell; Peter M Buttrick; Alan Koretsky; Pedro J del Nido; R John Solaro
alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2397-405.
2002: Beata M Wolska; Grace M Arteaga; James R Peña; Grzegorz Nowak; Ronald M Phillips; Shalini Sahai; Pieter P de Tombe; Anne F Martin; Evangelia G Kranias; R John Solaro
Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation.
Circulation research 2002;90(8):882-8.
2002: Catherine Communal; Marius Sumandea; Pieter P de Tombe; Jagat Narula; R John Solaro; Roger J Hajjar
Functional consequences of caspase activation in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6252-6.
2002: R John Solaro; Jamie Varghese; A J Marian; Murali Chandra
Molecular mechanisms of cardiac myofilament activation: modulation by pH and a troponin T mutant R92Q.
Basic research in cardiology 2002;97 Suppl 1():I102-10.
2002: Grace M Arteaga; Tomoyoshi Kobayashi; R John Solaro
Molecular actions of drugs that sensitize cardiac myofilaments to Ca2+.
Annals of medicine 2002;34(4):248-58.
2001: Beata M Wolska; K Vijayan; Grace M Arteaga; John P Konhilas; Ronald M Phillips; R Kim; T Naya; Jeffrey M Leiden; Anne F Martin; Pieter P de Tombe; R John Solaro
Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions.
The Journal of physiology 2001;536(Pt 3):863-70.
2001: Rethinasamy Prabhakar; Gregory P Boivin; Ingrid L Grupp; Brian D Hoit; Grace M Arteaga; R John Solaro; David F Wieczorek
A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice.
Journal of molecular and cellular cardiology 2001;33(10):1815-28.
2001: Xu Wang; Monica X Li; Leo Spyracopoulos; N Beier; Murali Chandra; R John Solaro; Brian D Sykes
Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.
The Journal of biological chemistry 2001;276(27):25456-66.
2001: G Li; Anne F Martin; R John Solaro
Localization of regions of troponin I important in deactivation of cardiac myofilaments by acidic pH.
Journal of molecular and cellular cardiology 2001;33(7):1309-20.
2001: Jonathan C Kentish; D T McCloskey; Joanne Layland; S Palmer; Jeffrey M Leiden; Anne F Martin; R John Solaro
Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle.
Circulation research 2001;88(10):1059-65.
2001: L Huang; Beata M Wolska; David E Montgomery; Eileen M Burkart; Peter M Buttrick; R John Solaro
Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta.
American journal of physiology. Cell physiology 2001;280(5):C1114-20.
2001: Rebecca S Keller; Shaw-Yung Shai; Christopher J Babbitt; Can G. Pham; R John Solaro; Maria L Valencik; Joseph C Loftus; Robert S Ross
Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance.
The American journal of pathology 2001;158(3):1079-90.
2001: David E Montgomery; Murali Chandra; Q Huang; J-P Jin; R John Solaro
Transgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of force.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1011-8.
2001: Guy A MacGowan; C Du; Douglas B Cowan; Christof Stamm; Francis X McGowan; R John Solaro; Alan Koretsky; P J Del Nido
Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H835-43.
2001: Murali Chandra; Veronica L M Rundell; Jil C Tardiff; Leslie A Leinwand; Pieter P de Tombe; R John Solaro
Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H705-13.
2000: Wen-Ji Dong; Jun Xing; M Chandra; R John Solaro; Herbert C Cheung
Structural mapping of single cysteine mutants of cardiac troponin I.
Proteins 2000;41(4):438-47.
2000: C C Evans; J R Pena; Ronald M Phillips; Mariappan Muthuchamy; David F Wieczorek; R John Solaro; Beata M Wolska
Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2000;279(5):H2414-23.
2000: R John Solaro
Myosin light chain phosphatase: a Cinderella of cellular signaling.
Circulation research 2000;87(3):173-5.
2000: Pieter P de Tombe; R John Solaro
Integration of cardiac myofilament activity and regulation with pathways signaling hypertrophy and failure.
Annals of biomedical engineering 2000;28(8):991-1001.
2000: Grace M Arteaga; KA Palmiter; Jeffrey M Leiden; R John Solaro
Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I.
The Journal of physiology 2000;526 Pt 3():541-9.
2000: MB Abbott; Vadim Gaponenko; Ekram M Abusamhadneh; Natosha L Finley; G Li; Alex Dvoretsky; Mark Rance; R John Solaro; Paul R Rosevear
Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I.
The Journal of biological chemistry 2000;275(27):20610-7.
1999: J Meehan; Mariann R Piano; R John Solaro; John M Kennedy
Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat.
Basic research in cardiology 1999;94(6):481-8.
1999: R John Solaro
Integration of myofilament response to Ca2+ with cardiac pump regulation and pump dynamics.
The American journal of physiology 1999;277(6 Pt 2):S155-63.
1999: R John Solaro
Is calcium the 'cure' for dilated cardiomyopathy?
Nature medicine 1999;5(12):1353-4.
1999: Wen-Ji Dong; Jun Xing; Matteo Villain; M Hellinger; John M Robinson; M Chandra; R John Solaro; Patrick K Umeda; Herbert C Cheung
Conformation of the regulatory domain of cardiac muscle troponin C in its complex with cardiac troponin I.
The Journal of biological chemistry 1999;274(44):31382-90.
1999: Dorie W Schwertz; Vida M Vizgirda; R John Solaro; Mariann R Piano; C Ryjewski
Sexual dimorphism in rat left atrial function and response to adrenergic stimulation.
Molecular and cellular biochemistry 1999;200(1-2):143-53.
1999: Murali Chandra; J J Kim; R John Solaro
An improved method for exchanging troponin subunits in detergent skinned rat cardiac fiber bundles.
Biochemical and biophysical research communications 1999;263(1):219-23.
1999: Mariappan Muthuchamy; Kathy Pieples; P Rethinasamy; Brian D Hoit; Ingrid L Grupp; Gregory P Boivin; Beata M Wolska; C Evans; R John Solaro; David F Wieczorek
Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.
Circulation research 1999;85(1):47-56.
1999: GM Gasmi-Seabrook; Jack W Howarth; Natosha L Finley; Ekram M Abusamhadneh; Vadim Gaponenko; Rui Brito; R John Solaro; Paul R Rosevear
Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I.
Biochemistry 1999;38(26):8313-22.
1999: Natosha L Finley; MB Abbott; Ekram M Abusamhadneh; Vadim Gaponenko; W Dong; GM Gasmi-Seabrook; Jack W Howarth; Mark Rance; R John Solaro; Herbert C Cheung; Paul R Rosevear
NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation.
FEBS letters 1999;453(1-2):107-12.
1999: Vadim Gaponenko; Ekram M Abusamhadneh; MB Abbott; Natosha L Finley; GM Gasmi-Seabrook; R John Solaro; Mark Rance; Paul R Rosevear
Effects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C.
The Journal of biological chemistry 1999;274(24):16681-4.
1999: Richard C Fentzke; Scott H Buck; Jitandrakumar R Patel; H Lin; Beata M Wolska; MO Stojanovic; Anne F Martin; R John Solaro; Richard L Moss; Jeffrey M Leiden
Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart.
The Journal of physiology 1999;517 ( Pt 1)():143-57.
1999: Beata M Wolska; Rebecca S Keller; C C Evans; KA Palmiter; Ronald M Phillips; Mariappan Muthuchamy; J Oehlenschlager; David F Wieczorek; Pieter P de Tombe; R John Solaro
Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin.
Circulation research 1999;84(7):745-51.
1999: Murali Chandra; David E Montgomery; J J Kim; R John Solaro
The N-terminal region of troponin T is essential for the maximal activation of rat cardiac myofilaments.
Journal of molecular and cellular cardiology 1999;31(4):867-80.
1999: HM Rarick; H P Tang; X D Guo; Anne F Martin; R John Solaro
Interactions at the NH2-terminal interface of cardiac troponin I modulate myofilament activation.
Journal of molecular and cellular cardiology 1999;31(2):363-75.
1999: Mariann R Piano; C Rosenblum; R John Solaro; Dorie W Schwertz
Calcium sensitivity and the effect of the calcium sensitizing drug pimobendan in the alcoholic isolated rat atrium.
Journal of cardiovascular pharmacology 1999;33(2):237-42.
1999: R John Solaro
Troponin I, stunning, hypertrophy, and failure of the heart.
Circulation research 1999;84(1):122-4.
1998: R John Solaro; HM Rarick
Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments.
Circulation research 1998;83(5):471-80.
1998: FM Powers; Bernard Fogelson; C Sturgeon; R John Solaro; William R Law
Depressed myofilament co-operativity associated with post-cardioplegic myocardial depression.
Journal of molecular and cellular cardiology 1998;30(9):1779-87.
1998: FM Powers; S Farias; H Minami; Anne F Martin; R John Solaro; William R Law
Cardiac myofilament protein function is altered during sepsis.
Journal of molecular and cellular cardiology 1998;30(5):967-78.
1998: Jennifer E Van Eyk; FM Powers; W Law; Catherine Larue; R S Hodges; R John Solaro
Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation.
Circulation research 1998;82(2):261-71.
1998: P Rethinasamy; Mariappan Muthuchamy; Timothy E Hewett; Greg Boivin; Beata M Wolska; C Evans; R John Solaro; David F Wieczorek
Molecular and physiological effects of alpha-tropomyosin ablation in the mouse.
Circulation research 1998;82(1):116-23.
1997: L D Fraker; Jennifer E Van Eyk; R John Solaro
Reversal of phosphate induced decreases in force by the benzimidazole pyridazinone, UD-CG 212 CL, in myofilaments from human ventricle.
Molecular and cellular biochemistry 1997;176(1-2):83-8.
1997: Murali Chandra; Wen-Ji Dong; B S Pan; Herbert C Cheung; R John Solaro
Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C.
Biochemistry 1997;36(43):13305-11.
1997: HM Rarick; X H Tu; R John Solaro; Anne F Martin
The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils.
The Journal of biological chemistry 1997;272(43):26887-92.
1997: Monica X Li; Stéphane M Gagné; Leo Spyracopoulos; C P Kloks; Gerald F Audette; Murali Chandra; R John Solaro; Lawrence B Smillie; Brian D Sykes
NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changes.
Biochemistry 1997;36(41):12519-25.
1997: Leo Spyracopoulos; Monica X Li; SK Sia; Stéphane M Gagné; Murali Chandra; R John Solaro; Brian D Sykes
Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.
Biochemistry 1997;36(40):12138-46.
1997: Beata M Wolska; V Averyhart-Fullard; A Omachi; M O Stojanović; R G Kallen; R John Solaro
Changes in thyroid state affect pHi and Nai+ homeostasis in rat ventricular myocytes.
Journal of molecular and cellular cardiology 1997;29(10):2653-63.
1997: Wen-Ji Dong; M Chandra; Jun Xing; M She; R John Solaro; Herbert C Cheung
Phosphorylation-induced distance change in a cardiac muscle troponin I mutant.
Biochemistry 1997;36(22):6754-61.
1997: Wen-Ji Dong; M Chandra; Jun Xing; R John Solaro; Herbert C Cheung
Conformation of the N-terminal segment of a monocysteine mutant of troponin I from cardiac muscle.
Biochemistry 1997;36(22):6745-53.
1997: KA Palmiter; R John Solaro
Molecular mechanisms regulating the myofilament response to Ca2+: implications of mutations causal for familial hypertrophic cardiomyopathy.
Basic research in cardiology 1997;92 Suppl 1():63-74.
1996: T A Noland; R L Raynor; N M Jideama; X Guo; Marcelo G Kazanietz; P M Blumberg; R John Solaro; J F Kuo
Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants.
Biochemistry 1996;35(47):14923-31.
1996: H M Rarick; T J Opgenorth; Thomas W von Geldern; J Ruth Wu-Wong; R John Solaro
An essential myosin light chain peptide induces supramaximal stimulation of cardiac myofibrillar ATPase activity.
The Journal of biological chemistry 1996;271(43):27039-43.
1996: Beata M Wolska; R John Solaro
Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry.
The American journal of physiology 1996;271(3 Pt 2):H1250-5.
1996: F M Powers; K A Palmiter; R John Solaro
E-1020, a water soluble imidazopyridine, has direct effects on Ca(2+)-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments.
Molecular and cellular biochemistry 1996;160-161():33-9.
1996: Beata M Wolska; M O Stojanovic; W Luo; Evangelia G Kranias; R John Solaro
Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca2+.
The American journal of physiology 1996;271(1 Pt 1):C391-7.
1996: G Wernberg; J M Gentry; R John Solaro
Association of Chairmen of Departments of Physiology 1995 survey results.
The Physiologist 1996;39(3):83-9.
1996: K A Palmiter; Y Kitada; Mariappan Muthuchamy; David F Wieczorek; R John Solaro
Exchange of beta- for alpha-tropomyosin in hearts of transgenic mice induces changes in thin filament response to Ca2+, strong cross-bridge binding, and protein phosphorylation.
The Journal of biological chemistry 1996;271(20):11611-4.
1996: W Luo; Beata M Wolska; Ingrid L Grupp; Judy M Harrer; Kobra Haghighi; DG Ferguson; Jay Slack; G Grupp; Thomas Doetschman; R John Solaro; Evangelia G Kranias
Phospholamban gene dosage effects in the mammalian heart.
Circulation research 1996;78(5):839-47.
1996: R John Solaro; Jennifer E Van Eyk
Altered interactions among thin filament proteins modulate cardiac function.
Journal of molecular and cellular cardiology 1996;28(2):217-30.
1996: Beata M Wolska; Y Kitada; K A Palmiter; Margaret V Westfall; M D Johnson; R John Solaro
CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction.
The American journal of physiology 1996;270(1 Pt 2):H24-32.
1995: T A Noland; X Guo; R L Raynor; N M Jideama; V Averyhart-Fullard; R John Solaro; J F Kuo
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1.
The Journal of biological chemistry 1995;270(43):25445-54.
1995: Quinn Kleerekoper; Jack W Howarth; X Guo; R John Solaro; Paul R Rosevear
Cardiac troponin I induced conformational changes in cardiac troponin C as monitored by NMR using site-directed spin and isotope labeling.
Biochemistry 1995;34(41):13343-52.
1995: István Ferenc Édes; E Kiss; Y Kitada; F M Powers; Julius Gy Papp; Evangelia G Kranias; R John Solaro
Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart.
Circulation research 1995;77(1):107-13.
1995: Jonggonnee Wattanapermpool; X Guo; R John Solaro
The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar activity only when it is phosphorylated.
Journal of molecular and cellular cardiology 1995;27(7):1383-91.
1995: F M Powers; R John Solaro
Caffeine alters cardiac myofilament activity and regulation independently of Ca2+ binding to troponin C.
The American journal of physiology 1995;268(6 Pt 1):C1348-53.
1995: Jonggonnee Wattanapermpool; P J Reiser; R John Solaro
Troponin I isoforms and differential effects of acidic pH on soleus and cardiac myofilaments.
The American journal of physiology 1995;268(2 Pt 1):C323-30.
1995: R John Solaro
Troponin C - troponin I interactions and molecular signalling in cardiac myofilaments.
Advances in experimental medicine and biology 1995;382():109-15.
1995: L Gao; John M Kennedy; R John Solaro
Differential expression of TnI and TnT isoforms in rabbit heart during the perinatal period and during cardiovascular stress.
Journal of molecular and cellular cardiology 1995;27(1):541-50.
1994: P J Reiser; Margaret V Westfall; S Schiaffino; R John Solaro
Tension production and thin-filament protein isoforms in developing rat myocardium.
The American journal of physiology 1994;267(4 Pt 2):H1589-96.
1994: G A Krudy; Quinn Kleerekoper; X Guo; Jack W Howarth; R John Solaro; Paul R Rosevear
NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex.
The Journal of biological chemistry 1994;269(38):23731-5.
1994: K L Ball; M D Johnson; R John Solaro
Isoform specific interactions of troponin I and troponin C determine pH sensitivity of myofibrillar Ca2+ activation.
Biochemistry 1994;33(28):8464-71.
1994: X Guo; Jonggonnee Wattanapermpool; K A Palmiter; Anne M Murphy; R John Solaro
Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation.
The Journal of biological chemistry 1994;269(21):15210-6.
1994: V Averyhart-Fullard; L D Fraker; Anne M Murphy; R John Solaro
Differential regulation of slow-skeletal and cardiac troponin I mRNA during development and by thyroid hormone in rat heart.
Journal of molecular and cellular cardiology 1994;26(5):609-16.
1994: K L Ball; R John Solaro
Discoordinate regulation of contractile protein gene expression in the senescent rat myocardium.
Journal of molecular and cellular cardiology 1994;26(4):519-25.
1993: R John Solaro; G Gambassi; D M Warshaw; M R Keller; Harold A Spurgeon; N Beier; Edward G Lakatta
Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments.
Circulation research 1993;73(6):981-90.
1993: Margaret V Westfall; G M Wahler; R John Solaro
A highly specific benzimidazole pyridazinone reverses phosphate-induced changes in cardiac myofilament activation.
Biochemistry 1993;32(39):10464-70.
1993: A Kawamura; G M Wahler; R John Solaro
RWJ-24517, a positive inotropic agent, has novel effects on action potentials in guinea pig myocardium.
Journal of cardiovascular pharmacology 1993;22(4):519-25.
1992: R John Solaro
Myosin and why hearts fail.
Circulation 1992;85(5):1945-7.
1992: Margaret V Westfall; R John Solaro
Alterations in myofibrillar function and protein profiles after complete global ischemia in rat hearts.
Circulation research 1992;70(2):302-13.
1992: Margaret V Westfall; G M Wahler; K Fujino; R John Solaro
Electrophysiological actions of the pimobendan metabolite, UD-CG 212 Cl, in guinea pig myocardium.
The Journal of pharmacology and experimental therapeutics 1992;260(1):58-63.
1991: Judith K Gwathmey; R J Hajjar; R John Solaro
Contractile deactivation and uncoupling of crossbridges. Effects of 2,3-butanedione monoxime on mammalian myocardium.
Circulation research 1991;69(5):1280-92.
1991: Anne F Martin; K Ball; L Z Gao; P Kumar; R John Solaro
Identification and functional significance of troponin I isoforms in neonatal rat heart myofibrils.
Circulation research 1991;69(5):1244-52.
1991: R John Solaro
Regulation of Ca(2+)-signaling in cardiac myofilaments.
Medicine and science in sports and exercise 1991;23(10):1145-8.
1990: B S Pan; K A Palmiter; M Plonczynski; R John Solaro
Slowly exchanging calcium binding sites unique to cardiac/slow muscle troponin C.
Journal of molecular and cellular cardiology 1990;22(10):1117-24.
1990: L J Dieckman; R John Solaro
Effect of thyroid status on thin-filament Ca2+ regulation and expression of troponin I in perinatal and adult rat hearts.
Circulation research 1990;67(2):344-51.
1990: Anne M Murphy; R John Solaro
Developmental difference in the stimulation of cardiac myofibrillar Mg2(+)-ATPase activity by calmidazolium.
Pediatric research 1990;28(1):46-9.
1990: J J McAuliffe; L Z Gao; R John Solaro
Changes in myofibrillar activation and troponin C Ca2+ binding associated with troponin T isoform switching in developing rabbit heart.
Circulation research 1990;66(5):1204-16.
1989: István Ferenc Édes; R John Solaro; Evangelia G Kranias
Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol.
Circulation research 1989;65(4):989-96.
1989: R John Solaro; S C el-Saleh; J C Kentish
Ca2+, pH and the regulation of cardiac myofilament force and ATPase activity.
Molecular and cellular biochemistry 1989;89(2):163-7.
1989: J W Herzig; L H Botelho; R John Solaro
Myofibrillar Ca++ activation and heart failure--Ca++ sensitization by the cardiotonic agent APP 201-533.
Basic research in cardiology 1989;84 Suppl 1():117-24.
1989: K Fujino; N Sperelakis; R John Solaro
Direct effects of pimobendan on cardiac myofilaments.
Progress in clinical and biological research 1989;315():602-3.
1989: S T Rapundalo; R John Solaro; Evangelia G Kranias
Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins.
Circulation research 1989;64(1):104-11.
1989: R John Solaro; S C el-Saleh; J Kentish; A Meyer; Anne F Martin
Transitions in isoform populations of thick and thin filament proteins and calcium activation of force and ATP hydrolysis by cardiac myofilaments.
Progress in clinical and biological research 1989;315():487-502.
1989: R John Solaro; K Fujino; Nicholas Sperelakis
The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments.
Journal of cardiovascular pharmacology 1989;14 Suppl 2():S7-12.
1988: K Fujino; Nicholas Sperelakis; R John Solaro
Differential effects of d- and l-pimobendan on cardiac myofilament calcium sensitivity.
The Journal of pharmacology and experimental therapeutics 1988;247(2):519-23.
1988: K Fujino; Nicholas Sperelakis; R John Solaro
Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone.
Circulation research 1988;63(5):911-22.
1988: R John Solaro; J A Lee; J C Kentish; D G Allen
Effects of acidosis on ventricular muscle from adult and neonatal rats.
Circulation research 1988;63(4):779-87.
1988: G Jakab; S T Rapundalo; R John Solaro; Evangelia G Kranias
Phosphorylation of phospholipids in isolated guinea pig hearts stimulated with isoprenaline.
The Biochemical journal 1988;251(1):189-94.
1988: S C el-Saleh; R John Solaro
Troponin I enhances acidic pH-induced depression of Ca2+ binding to the regulatory sites in skeletal troponin C.
The Journal of biological chemistry 1988;263(7):3274-8.
1988: J L Garvey; Evangelia G Kranias; R John Solaro
Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts.
The Biochemical journal 1988;249(3):709-14.
1988: J T Whitmer; P Kumar; R John Solaro
Calcium transport properties of cardiac sarcoplasmic reticulum from cardiomyopathic Syrian hamsters (BIO 53.58 and 14.6): evidence for a quantitative defect in dilated myopathic hearts not evident in hypertrophic hearts.
Circulation research 1988;62(1):81-5.
1987: S C el-Saleh; R John Solaro
Calmidazolium, a calmodulin antagonist, stimulates calcium-troponin C and calcium-calmodulin-dependent activation of striated muscle myofilaments.
The Journal of biological chemistry 1987;262(35):17240-6.
1987: B S Pan; R John Solaro
Calcium-binding properties of troponin C in detergent-skinned heart muscle fibers.
The Journal of biological chemistry 1987;262(16):7839-49.
1986: S C el-Saleh; James D Potter; R John Solaro
Alteration of actin-tropomyosin interaction in 2,4-pentanedione-treated rabbit skeletal myofibrils.
The Journal of biological chemistry 1986;261(31):14646-50.
1986: R John Solaro; P Bousquet; J D Johnson
Stimulation of cardiac myofilament force, ATPase activity and troponin C Ca++ binding by bepridil.
The Journal of pharmacology and experimental therapeutics 1986;238(2):502-7.
1986: R John Solaro; P Kumar; E M Blanchard; Anne F Martin
Differential effects of pH on calcium activation of myofilaments of adult and perinatal dog hearts. Evidence for developmental differences in thin filament regulation.
Circulation research 1986;58(5):721-9.
1986: W Rouslin; J L Erickson; R John Solaro
Effects of oligomycin and acidosis on rates of ATP depletion in ischemic heart muscle.
The American journal of physiology 1986;250(3 Pt 2):H503-8.
1986: S T Rapundalo; Ingrid L Grupp; G Grupp; M Abdul Matlib; R John Solaro; A Schwartz
Myocardial actions of milrinone: characterization of its mechanism of action.
Circulation 1986;73(3 Pt 2):III134-44.
1985: T Li; N Sperelakis; R E Teneick; R John Solaro
Effects of diacetyl monoxime on cardiac excitation-contraction coupling.
The Journal of pharmacology and experimental therapeutics 1985;232(3):688-95.
1985: Evangelia G Kranias; J L Garvey; R D Srivastava; R John Solaro
Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline.
The Biochemical journal 1985;226(1):113-21.
1984: E D Pagani; R John Solaro
Coordination of cardiac myofibrillar and sarcotubular activities in rats exercised by swimming.
The American journal of physiology 1984;247(6 Pt 2):H909-15.
1984: J S Shiner; R John Solaro
The hill coefficient for the Ca2+-activation of striated muscle contraction.
Biophysical journal 1984;46(4):541-3.
1984: E M Blanchard; R John Solaro
Inhibition of the activation and troponin calcium binding of dog cardiac myofibrils by acidic pH.
Circulation research 1984;55(3):382-91.
1984: E M Blanchard; B S Pan; R John Solaro
The effect of acidic pH on the ATPase activity and troponin Ca2+ binding of rabbit skeletal myofilaments.
The Journal of biological chemistry 1984;259(5):3181-6.
1983: K Imai; T Wang; R W Millard; M Ashraf; E G Kranias; G Asano; A O Grassi de Gende; T Nagao; R John Solaro; A Schwartz
Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum.
Cardiovascular research 1983;17(11):696-709.
1983: E D Pagani; R John Solaro
Swimming exercise, thyroid state, and the distribution of myosin isoenzymes in rat heart.
The American journal of physiology 1983;245(5 Pt 1):H713-20.
1983: R John Solaro; J DiSalvo; R J Paul
Coordination of metabolism and contractility by phosphorylation in cardiac, skeletal, and smooth muscle. Introduction.
Federation proceedings 1983;42(1):7-8.
1983: E G Kranias; R John Solaro
Coordination of cardiac sarcoplasmic reticulum and myofibrillar function by protein phosphorylation.
Federation proceedings 1983;42(1):33-8.
1982: R John Solaro; J C Rüegg
Stimulation of Ca++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent.
Circulation research 1982;51(3):290-4.
1982: J S Shiner; R John Solaro
Activation of thin-filament-regulated muscle by calcium ion: considerations based on nearest-neighbor lattice statistics.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4637-41.
1982: E G Kranias; R John Solaro
Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart.
Nature 1982;298(5870):182-4.
1982: S P Robertson; J D Johnson; M J Holroyde; E G Kranias; James D Potter; R John Solaro
The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin.
The Journal of biological chemistry 1982;257(1):260-3.
1982: Anne F Martin; E D Pagani; R John Solaro
Thyroxine-induced redistribution of isoenzymes of rabbit ventricular myosin.
Circulation research 1982;50(1):117-24.
1982: J W Herzig; J W Peterson; R John Solaro; J C Rüegg
Phosphate and vanadate reduce the efficiency of the chemo-mechanical energy transformation in cardiac muscle.
Advances in experimental medicine and biology 1982;151():267-81.
1981: J D Johnson; M J Holroyde; T H Crouch; R John Solaro; James D Potter
Fluorescence studies of the interaction of calmodulin with myosin light chain kinase.
The Journal of biological chemistry 1981;256(23):12194-8.
1981: T H Crouch; M J Holroyde; J H Collins; R John Solaro; James D Potter
Interaction of calmodulin with skeletal muscle myosin light chain kinase.
Biochemistry 1981;20(22):6318-25.
1981: J S Shiner; R John Solaro
The effects of modifiers on enzyme catalysis: a non-classical nearest neighbor approach.
Biophysical chemistry 1981;13(4):291-306.
1981: P J Silver; M J Holroyde; R John Solaro; J Disalvo
Ca2+, calmodulin and cyclic AMP-dependent modulation of actin-myosin interactions in aorta.
Biochimica et biophysica acta 1981;674(1):65-70.
1981: R Z Litten; B J Martin; E R Howe; Norman R Alpert; R John Solaro
Phosphorylation and adenosine triphosphatase activity of myofibrils from thyrotoxic rabbit hearts.
Circulation research 1981;48(4):498-501.
1981: J W Herzig; J W Peterson; J C Rüegg; R John Solaro
Vanadate and phosphate ions reduce tension and increase cross-bridge kinetics in chemically skinned heart muscle.
Biochimica et biophysica acta 1981;672(2):191-6.
1980: M J Holroyde; S P Robertson; J D Johnson; R John Solaro; James D Potter
The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase.
The Journal of biological chemistry 1980;255(24):11688-93.
1980: R John Solaro; M J Holroyde; T Wang; Mohammed A Matlib; Ingrid L Grupp; G Grupp; A Schwartz
Effects of vanadate on biochemical and contractile properties of rabbit hearts.
Journal of cardiovascular pharmacology 1980;2(4):445-52.
1980: A Schwartz; R J Adams; Ingrid L Grupp; G Grupp; M J Holroyde; R W Millard; R John Solaro; E T Wallick
Effects of vanadate on myocardial function.
Basic research in cardiology 1980;75(3):444-51.
1980: Arthur J G Moir; R John Solaro; S Victor Perry
The site of phosphorylation of troponin I in the perfused rabbit heart. The effect of adrenaline.
The Biochemical journal 1980;185(2):505-13.
1980: R John Solaro; M J Holroyde; J W Herzig; J Peterson
Cardiac relaxation and myofibrillar interactions with phosphate and vanadate.
European heart journal 1980;Suppl A():21-7.
1979: T Wang; L I Tsai; R John Solaro; A O Grassi de Gende; A Schwartz
Effects of potassium on vanadate inhibition of sarcoplasmic reticulum Ca2+-ATPase from dog cardiac and rabbit skeletal muscle.
Biochemical and biophysical research communications 1979;91(1):356-61.
1979: M J Holroyde; D A Small; E Howe; R John Solaro
Isolation of cardiac myofibrils and myosin light chains with in vivo levels of light chain phosphorylation.
Biochimica et biophysica acta 1979;587(4):628-37.
1979: M J Holroyde; James D Potter; R John Solaro
The calcium binding properties of phosphorylated and unphosphorylated cardiac and skeletal myosins.
The Journal of biological chemistry 1979;254(14):6478-82.
1979: R Z Litten; R John Solaro; G D Ford
Nature of the calcium regulatory system of bovine arterial actomyosin.
Blood vessels 1979;16(1):26-34.
1977: R Z Litten; R John Solaro; G D Ford
Properties of the calcium-sensitive components of bovine arterial actomyosin.
Archives of biochemistry and biophysics 1977;182(1):24-32.
1977: F N Briggs; J L Poland; R John Solaro
Relative capabilities of sarcoplasmic reticulum in fast and slow mammalian skeletal muscles.
The Journal of physiology 1977;266(3):587-94.
1976: N Frearson; R John Solaro; S V Perry
Changes in phosphorylation of P light chain of myosin in perfused rabbit heart.
Nature 1976;264(5588):801-2.
1976: R John Solaro; F D Bruni; E N Gleason
Effects of ionic strength on calcium binding to rabbit skeletal myofibrils, thin filaments and myosin.
Biochimica et biophysica acta 1976;449(2):304-9.
1976: R John Solaro; A J Moir; S V Perry
Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart.
Nature 1976;262(5569):615-7.
1976: R John Solaro; J S Shiner
Modulation of Ca2+ control of dog and rabbit cardiac myofibrils by Mg2+. Comparison with rabbit skeletal myofibrils.
Circulation research 1976;39(1):8-14.
1976: H A Cole; N Frearson; A J Moir; S V Perry; R John Solaro
Phosphorylation of cardiac myofibrillar proteins.
Recent advances in studies on cardiac structure and metabolism 1976;11():111-20.
1975: R John Solaro
Calcium regulation of cardiac myofibrillar activation: effects of MgATP.
Journal of supramolecular structure 1975;3(4):368-75.
1974: R John Solaro; F N Briggs
Estimating the functional capabilities of sarcoplasmic reticulum in cardiac muscle. Calcium binding.
Circulation research 1974;34(4):531-40.
1974: R John Solaro; R M Wise; J S Shiner; F N Briggs
Calcium requirements for cardiac myofibrillar activation.
Circulation research 1974;34(4):525-30.
1974: M L Hess; R John Solaro; F N Briggs
Polyhydroxyl and temperature antagonism of the inhibitory effects of gram-negative endotoxin on the calcium-uptake activity of cardiac sarcoplasmic reticulum.
Recent advances in studies on cardiac structure and metabolism 1974;4():451-60.
1974: R John Solaro; F N Briggs
Calcium conservation and the regulation of myocardial contraction.
Recent advances in studies on cardiac structure and metabolism 1974;4():359-74.
1972: R John Solaro; E W Gertz; F N Briggs
Sucrose antagonism of drug and temperature effects on cardiac sarcoplasmic reticulum.
Biochimica et biophysica acta 1972;255(3):751-6.
1971: R John Solaro; D C Pang; F N Briggs
The purification of cardiac myofibrils with Triton X-100.
Biochimica et biophysica acta 1971;245(1):259-62.
1969: J P Buckley; R John Solaro; H Barry
Effects of phenformin HC1 on rats subjected to simulated high altitude.
Journal of pharmaceutical sciences 1969;58(3):348-51.