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Connie Sommers

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Robert L Kortum; Wenmei Li; Evan Markegard; Robert K Merrill; Michihiko Miyaji; Nandan N Nath; John M Pinski; Jeroen P Roose; Alexandre K Rouquette-Jazdanian; Lawrence E Samelson; Clayton P Alexander; Peter M Blumberg; Noemi Kedei; Amelia Wesselink; Connie L Sommers
A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
Alexandre K Rouquette-Jazdanian; Robert L Kortum; Deborah K Morrison; Connie L Sommers; Lawrence E Samelson
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.
Robert L Kortum; Wenmei Li; Paul E Love; Robert K Merrill; John M Pinski; Clayton P Alexander; Connie L Sommers; Lawrence E Samelson
Deconstructing Ras signaling in the thymus.

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All Publications

2013: Robert L Kortum; Wenmei Li; Evan Markegard; Robert K Merrill; Michihiko Miyaji; Nandan N Nath; John M Pinski; Jeroen P Roose; Alexandre K Rouquette-Jazdanian; Lawrence E Samelson; Clayton P Alexander; Peter M Blumberg; Noemi Kedei; Amelia Wesselink; Connie L Sommers
A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):147-58.
2012: Alexandre K Rouquette-Jazdanian; Robert L Kortum; Deborah K Morrison; Connie L Sommers; Lawrence E Samelson
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.
Molecular cell 2012;48(2):298-312.
2012: Robert L Kortum; Wenmei Li; Paul E Love; Robert K Merrill; John M Pinski; Clayton P Alexander; Connie L Sommers; Lawrence E Samelson
Deconstructing Ras signaling in the thymus.
Molecular and cellular biology 2012;32(14):2748-59.
2011: Eilon Sherman; Connie L Sommers; Itoro Akpan; Lakshmi Balagopalan; Valarie A Barr; Jennifer Lippincott-Schwartz; Suliana Manley; Robert K Merrill; George Patterson; Carole K Regan; Lawrence E Samelson
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.
Immunity 2011;35(5):705-20.
2011: Robert L Kortum; Jan Lee; Wenmei Li; Paul E Love; John M Pinski; Clayton P Alexander; Alex Grinberg; Connie L Sommers; Lawrence E Samelson
Targeted Sos1 deletion reveals its critical role in early T-cell development.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12407-12.
2010: Lakshmi Balagopalan; Nathan P Coussens; Eilon Sherman; Lawrence E Samelson; Connie L Sommers
The LAT story: a tale of cooperativity, coordination, and choreography.
Cold Spring Harbor perspectives in biology 2010;2(8):a005512.
2009: Michihiko Miyaji; Robert L Kortum; Rishi Surana; Wenmei Li; Kevin D Woolard; R Mark Simpson; Lawrence E Samelson; Connie L Sommers
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14502-7.
2008: Valarie A Barr; Kelsie M Bernot; Sonal Srikanth; Yousang Gwack; Lakshmi Balagopalan; Carole K Regan; Daniel J Helman; Connie L Sommers; Masatsugu Oh-hora; Anjana Rao; Lawrence E Samelson
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.
Molecular biology of the cell 2008;19(7):2802-17.
2008: Connie L Sommers; Jordan M Gurson; Rishi Surana; Mira Barda-Saad; Jan Lee; Aparna Kishor; Wenmei Li; Adam J Gasser; Valarie A Barr; Michihiko Miyaji; Paul E Love; Lawrence E Samelson
Bam32: a novel mediator of Erk activation in T cells.
International immunology 2008;20(7):811-8.
2007: Lakshmi Balagopalan; Valarie A Barr; Connie L Sommers; Mira Barda-Saad; Amrita Goyal; Matthew S Isakowitz; Lawrence E Samelson
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Molecular and cellular biology 2007;27(24):8622-36.
2006: Alex Braiman; Mira Barda-Saad; Connie L Sommers; Lawrence E Samelson
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.
The EMBO journal 2006;25(4):774-84.
2005: Connie L Sommers; Jan Lee; Kevin L Steiner; Jordan M Gurson; Corinne L Depersis; Dalal El-Khoury; Claudette L Fuller; Elizabeth W Shores; Paul E Love; Lawrence E Samelson
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
The Journal of experimental medicine 2005;201(7):1125-34.
2004: Y Jeffrey Chiang; Connie L Sommers; Martha S Jordan; Hua Gu; Lawrence E Samelson; Gary A Koretzky; Richard J Hodes
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.
The Journal of experimental medicine 2004;200(1):25-34.
2004: Kenneth Jeffrey Woodside; Howard Shen; Christiana Muntzel; John A Daller; Connie L Sommers; Paul E Love
Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.
Gene expression patterns : GEP 2004;4(3):315-20.
2004: Connie L Sommers; Lawrence E Samelson; Paul E Love
LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(1):61-7.
2003: Shin-ichiroh Saitoh; Sandra Odom; Gregorio Gomez; Connie L Sommers; Howard A Young; Juan Rivera; Lawrence E Samelson
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.
The Journal of experimental medicine 2003;198(5):831-43.
2002: Connie L Sommers; Cheung-Seog Park; Jan Lee; Chiguang Feng; Claudette L Fuller; Alexander Grinberg; Jay A Hildebrand; Emanuela Lacaná; Rashmi K Menon; Elizabeth W Shores; Lawrence E Samelson; Paul E Love
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
Science (New York, N.Y.) 2002;296(5575):2040-3.
2001: Connie L Sommers; R K Menon; Alexander Grinberg; W Zhang; Lawrence E Samelson; Paul E Love
Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.
The Journal of experimental medicine 2001;194(2):135-42.
2001: Hala S Azzam; JB DeJarnette; K Huang; R Emmons; C S Park; Connie L Sommers; Dalal El-Khoury; Elizabeth W Shores; Paul E Love
Fine tuning of TCR signaling by CD5.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5464-72.
2000: Connie L Sommers; JB DeJarnette; K Huang; Jan Lee; Dalal El-Khoury; Elizabeth W Shores; Paul E Love
Function of CD3 epsilon-mediated signals in T cell development.
The Journal of experimental medicine 2000;192(6):913-19.
2000: Shin-ichiroh Saitoh; Ramachandran Arudchandran; Timothy Scott Manetz; W Zhang; Connie L Sommers; Paul E Love; Juan Rivera; Lawrence E Samelson
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
Immunity 2000;12(5):525-35.
1999: K Rajagopal; Connie L Sommers; Donna C Decker; E O Mitchell; U Korthauer; Anne I Sperling; C A Kozak; Paul E Love; Jeffrey A Bluestone
RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
The Journal of experimental medicine 1999;190(11):1657-68.
1999: JM Pasquet; B Gross; LS Quek; Naoki Asazuma; W Zhang; Connie L Sommers; Edina Schweighoffer; Victor L J Tybulewicz; B Judd; J R Lee; Gary A Koretzky; Paul E Love; Lawrence E Samelson; Steve P Watson
LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
Molecular and cellular biology 1999;19(12):8326-34.
1999: Connie L Sommers; R L Rabin; Alexander Grinberg; H C Tsay; J Farber; Paul E Love
A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection.
The Journal of experimental medicine 1999;190(10):1427-38.
1999: W Zhang; Connie L Sommers; Deborah N Burshtyn; C C Stebbins; JB DeJarnette; RP Trible; Alexander Grinberg; H C Tsay; Helena M Jacobs; Craig M Kessler; Eric Long; Paul E Love; Lawrence E Samelson
Essential role of LAT in T cell development.
Immunity 1999;10(3):323-32.
1998: JB DeJarnette; Connie L Sommers; K Huang; Kenneth Jeffrey Woodside; R Emmons; K Katz; Elizabeth W Shores; Paul E Love
Specific requirement for CD3epsilon in T cell development.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14909-14.
1998: Elizabeth W Shores; M Ono; T Kawabe; Connie L Sommers; T Tran; K Lui; M C Udey; J Ravetch; Paul E Love
T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).
The Journal of experimental medicine 1998;187(7):1093-101.
1997: Elizabeth W Shores; T Tran; Alexander Grinberg; Connie L Sommers; H Shen; Paul E Love
Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.
The Journal of experimental medicine 1997;185(5):893-900.
1996: K Huang; Connie L Sommers; Alexander Grinberg; C A Kozak; Paul E Love
Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.
Oncogene 1996;13(7):1567-73.
1995: Connie L Sommers; K Huang; Elizabeth W Shores; Alexander Grinberg; D A Charlick; C A Kozak; Paul E Love
Murine txk: a protein tyrosine kinase gene regulated by T cell activation.
Oncogene 1995;11(2):245-51.