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Andrew Somogyi

Research Profile

Chemicals & Drugs

Procedures

High Pressure Liquid Chromatography

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Microsomes, Liver

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Publications

TOP 3
Yibai Li; Nathan J Stanley; Ulrich M Zanger; Andrew D Abell; Janet K Coller; Mark R Hutchinson; Kathrin Klein; Andrew A Somogyi
The CYP2B6*6 Allele Significantly Alters the N-Demethylation of Ketamine Enantiomers In Vitro.
John Maddison; Melanie Gentgall; Heather M James; Berit P Jensen; Andrew A Somogyi; Paul Rolan
The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype.
Janet K Coller; Joel Colvill; Aaron L Farquharson; Heather M James; Jennifer R Michalakas; Jason M White; Andrew A Somogyi
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients.

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2013: Yibai Li; Nathan J Stanley; Ulrich M Zanger; Andrew D Abell; Janet K Coller; Mark R Hutchinson; Kathrin Klein; Andrew A Somogyi
The CYP2B6*6 Allele Significantly Alters the N-Demethylation of Ketamine Enantiomers In Vitro.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(6):1264-72.
2013: John Maddison; Melanie Gentgall; Heather M James; Berit P Jensen; Andrew A Somogyi; Paul Rolan
The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype.
British journal of clinical pharmacology 2013;75(1):208-16.
2012: Janet K Coller; Joel Colvill; Aaron L Farquharson; Heather M James; Jennifer R Michalakas; Jason M White; Andrew A Somogyi
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients.
British journal of clinical pharmacology 2012;74(5):835-41.
2012: Mark Hutchinson; J L Katz; Theresa A Kopajtic; S S Lewis; L C Loram; Steven F Maier; T Maslanik; N E Miles; A L Northcutt; Kenner C Rice; R R Rozeske; C Sfregola; Andrew A Somogyi; K A Strand; J Thomas; K van Steeg; X Wang; Jose Amat; Ryan K Bachtell; Sondra T Bland; T R Chapman; Monika Fleshner; E Galer; Takato Hiranita; H Yin; Linda R Watkins
Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(33):11187-200.
2012: Eloise A Gelston; Heather M James; Olga V Lopatko; Helmut Schmidt; Janet K Coller; Jason M White; Andrew A Somogyi
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.
British journal of clinical pharmacology 2012;73(5):786-94.
2012: Xiaohui Wang; Linda R Watkins; Kui Cheng; Armando J de Jesus; Mark Hutchinson; Lisa C Loram; Khara Ramos; Anireddy Reddy; Andrew A Somogyi; Jacob Thomas; Hang Yin
Morphine activates neuroinflammation in a manner parallel to endotoxin.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6325-30.
2012: Yue Wu; Janet K Coller; John D Hayball; Erin L Lousberg; Lachlan M Moldenhauer; Kenner C Rice; Andrew A Somogyi; Linda R Watkins; Mark Hutchinson
Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.
British journal of pharmacology 2012;165(5):1319-29.
2012: Daniel T Barratt; Andrew Byrne; Janet K Coller; David J R Foster; Richard Hallinan; Jason M White; Andrew A Somogyi
ABCB1 haplotype and OPRM1 118A > G genotype interaction in methadone maintenance treatment pharmacogenetics.
Pharmacogenomics and personalized medicine 2012;5():53-62.
2011: Janet K Coller; Carolyn Edmonds; Aaron L Farquharson; Marie Longo; Rinaldo Minniti; Andrew A Somogyi; Thomas Sullivan; Sharon Cahill; Jason M White
OPRM1 A118G genotype fails to predict the effectiveness of naltrexone treatment for alcohol dependence.
Pharmacogenetics and genomics 2011;21(12):902-5.
2011: Liang Liu; Andrew A Somogyi; Linda R Watkins; Janet K Coller; Mark Hutchinson
Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains.
Brain, behavior, and immunity 2011;25(6):1223-32.
2011: Yue Wu; Erin L Lousberg; Lachlan M Moldenhauer; John D Hayball; Sarah A Robertson; Janet K Coller; Linda R Watkins; Andrew A Somogyi; Mark Hutchinson
Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
Brain, behavior, and immunity 2011;25 Suppl 1():S155-64.
2011: Peter Grace; Mark Hutchinson; Alan Bishop; Andrew A Somogyi; Graham Mayrhofer; Paul Rolan
Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain.
Brain, behavior, and immunity 2011;25(3):503-13.
2011: J L Hay; Sophie F La Vincente; Andrew A Somogyi; C B Chapleo; Jason M White
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects.
European journal of pain (London, England) 2011;15(3):293-8.
2010: Andrea L Gordon; Olga V Lopatko; Andrew A Somogyi; David J R Foster; Jason M White
(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy.
British journal of clinical pharmacology 2010;70(6):895-902.
2010: Richard N Upton; Andrew A Somogyi; A M Martinez; J Colvill; Cliff Grant
Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep.
British journal of anaesthesia 2010;105(6):798-809.
2010: Peter Grace; Mark R Hutchinson; Jim Manavis; Andrew A Somogyi; Paul E Rolan
A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity.
Journal of neuroscience methods 2010;193(1):47-53.
2010: Pritsana Raungrut; Verawan Uchaipichat; David J Elliot; Benjamas Janchawee; Andrew A Somogyi; John O Miners
In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans.
The Journal of pharmacology and experimental therapeutics 2010;334(2):609-18.
2009: Liang Liu; Mark Hutchinson; Jason M White; Andrew A Somogyi; Janet K Coller
Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence.
Pharmacogenetics and genomics 2009;19(11):869-76.
2009: Justin L Hay; Jason M White; Felix Bochner; Andrew A Somogyi; Tim J Semple; Bruce Rounsefell
Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients.
The journal of pain : official journal of the American Pain Society 2009;10(3):316-22.
2009: Janet K Coller; Lona L Christrup; Andrew A Somogyi
Role of active metabolites in the use of opioids.
European journal of clinical pharmacology 2009;65(2):121-39.
2009: Janet K Coller; Timothy C Cox; Yibai Li; Florence Merg; Julia Beardsley; James Bignold; Thomas Sullivan; Andrew A Somogyi
Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis.
Pharmacogenomics and personalized medicine 2009;2():9-19.
2008: Andrew A Somogyi; Mie Larsen; Reza M Abadi; Jaroon Jittiwutikarn; Robert Ali; Jason M White
Flexible dosing of tincture of opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics.
British journal of clinical pharmacology 2008;66(5):640-7.
2008: Mark Hutchinson; Benjamen D Coats; Susannah S Lewis; Yingning Zhang; David B Sprunger; Niloofar Rezvani; Eric M Baker; Brian M Jekich; Julie L Wieseler; Andrew A Somogyi; David Martin; Stephen Poole; Charles M Judd; Steven F Maier; Linda R Watkins
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Brain, behavior, and immunity 2008;22(8):1178-89.
2008: Justin L Hay; Jason M White; Felix Bochner; Andrew A Somogyi
Antinociceptive effects of high-dose remifentanil in male methadone-maintained patients.
European journal of pain (London, England) 2008;12(7):926-33.
2008: Benjamin J Davies; Megan K Herbert; Janet K Coller; Andrew A Somogyi; Robert W Milne; Benedetta C Sallustio
Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline.
British journal of clinical pharmacology 2008;65(3):347-54.
2008: Sophie F La Vincente; Jason M White; Andrew A Somogyi; Felix Bochner; C B Chapleo
Enhanced buprenorphine analgesia with the addition of ultra-low-dose naloxone in healthy subjects.
Clinical pharmacology and therapeutics 2008;83(1):144-52.
2007: Janet K Coller; C Joergensen; David J R Foster; Heather M James; David Gillis; Lona L Christrup; Andrew A Somogyi
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
International journal of clinical pharmacology and therapeutics 2007;45(7):410-7.
2007: Sally C Inglis; Megan K Herbert; Benjamin J Davies; Janet K Coller; Heather M James; John D Horowitz; Raymond G Morris; Robert W Milne; Andrew A Somogyi; Benedetta C Sallustio
Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.
Pharmacogenetics and genomics 2007;17(5):305-12.
2007: Andrew A Somogyi; Daniel T Barratt; Janet K Coller
Pharmacogenetics of opioids.
Clinical pharmacology and therapeutics 2007;81(3):429-44.
2007: Svitlana Igel; Siegfried Drescher; Thomas E Mürdter; ute hofmann; Georg Heinkele; Heike Tegude; Hartmut Glaeser; Stefanie S Brenner; Andrew A Somogyi; Taher Omari; Christian Schäfer; Michel Eichelbaum; Martin F Fromm
Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux.
Clinical pharmacokinetics 2007;46(9):777-85.
2007: Benjamin J Davies; Janet K Coller; Andrew A Somogyi; Robert W Milne; Benedetta C Sallustio
CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(1):128-38.
2006: Janet K Coller; Daniel T Barratt; Karianne Dahlen; Morten H Loennechen; Andrew A Somogyi
ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals.
Clinical pharmacology and therapeutics 2006;80(6):682-90.
2006: Benjamin J Davies; Megan K Herbert; Janet K Coller; Andrew A Somogyi; Robert W Milne; Benedetta C Sallustio
Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;843(2):302-9.
2006: Hanne H Villesen; David J R Foster; Richard N Upton; Lona L Christrup; Andrew A Somogyi; A Martinez; Cliff Grant
Blood-brain distribution of morphine-6-glucuronide in sheep.
British journal of pharmacology 2006;149(6):754-60.
2006: David J R Foster; Erin B Morton; Georg Heinkele; Thomas E Mürdter; Andrew A Somogyi
Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subject.
Therapeutic drug monitoring 2006;28(4):559-67.
2006: Hanne H Villesen; David J R Foster; Richard N Upton; Andrew A Somogyi; Allison Martinez; Cliff Grant
Cerebral kinetics of oxycodone in conscious sheep.
Journal of pharmaceutical sciences 2006;95(8):1666-76.
2006: Timothy Mitchell; Jason M White; Andrew A Somogyi; Felix Bochner
Switching between methadone and morphine for maintenance treatment of opioid dependence: impact on pain sensitivity and mood status.
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions 2006;15(4):311-5.
2006: Daniel T Barratt; Janet K Coller; Andrew A Somogyi
Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(4):323-31.
2006: Timothy Mitchell; Kyle R Dyer; David A L Newcombe; Andrew A Somogyi; Jason M White
Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients.
Addiction biology 2006;11(2):170-4.
2006: Thomas M Polasek; David J Elliot; Andrew A Somogyi; Elizabeth M J Gillam; Benjamin C Lewis; John O Miners
An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid.
British journal of clinical pharmacology 2006;61(5):570-84.
2006: Glynn A Morrish; David J R Foster; Andrew A Somogyi
Differential in vitro inhibition of M3G and M6G formation from morphine by (R)- and (S)-methadone and structurally related opioids.
British journal of clinical pharmacology 2006;61(3):326-35.
2006: Benjamin J Davies; Janet K Coller; Heather M James; Andrew A Somogyi; John D Horowitz; Benedetta C Sallustio
The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia.
British journal of clinical pharmacology 2006;61(3):321-5.
2006: Benjamin J Davies; Megan K Herbert; Julie A Culbert; Simon Pyke; Janet K Coller; Andrew A Somogyi; Robert W Milne; Benedetta C Sallustio
Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;832(1):114-20.
2006: Peter Athanasos; Charlotte S Smith; Jason M White; Andrew A Somogyi; Felix Bochner; Walter Ling
Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations.
Pain 2006;120(3):267-75.
2006: David J R Foster; Mette L Jensen; Richard N Upton; Andrew A Somogyi; Cliff Grant; Allison Martinez
Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation.
British journal of pharmacology 2006;147(2):209-17.
2005: Mark Hutchinson; Andrew A Somogyi
Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids.
International immunopharmacology 2005;5(12):1713-22.
2005: Julia Hanna; David J R Foster; Amy Salter; Andrew A Somogyi; Jason M White; Felix Bochner
Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects.
British journal of clinical pharmacology 2005;60(4):404-13.
2005: David J R Foster; Richard N Upton; Andrew A Somogyi; Cliff Grant; Allison Martinez
The acute disposition of (R)- and (s)-methadone in brain and lung of sheep.
Journal of pharmacokinetics and pharmacodynamics 2005;32(3-4):547-70.
2004: Heather M James; Janet K Coller; David Gillis; J Bahnisch; Benedetta C Sallustio; Andrew A Somogyi
A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis.
International journal of clinical pharmacology and therapeutics 2004;42(12):719-23.
2004: Timothy Mitchell; Kyle R Dyer; David A L Newcombe; Amy Salter; Andrew A Somogyi; Felix Bochner; Jason M White
Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure.
British journal of clinical pharmacology 2004;58(6):609-17.
2004: Jaroon Jittiwutikarn; Robert Ali; Jason M White; Felix Bochner; Andrew A Somogyi; David J R Foster
Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre.
British journal of clinical pharmacology 2004;58(5):536-41.
2004: Mark Hutchinson; Andrew A Somogyi
(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone.
International immunopharmacology 2004;4(12):1525-30.
2004: David A L Newcombe; Felix Bochner; Jason M White; Andrew A Somogyi
Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis.
Drug and alcohol dependence 2004;76(1):63-72.
2004: Andrew A Somogyi; Andrew Menelaou; S V Fullston
CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(10):875-87.
2004: Hartmut Glaeser; Siegfried Drescher; ute hofmann; Georg Heinkele; Andrew A Somogyi; Michel Eichelbaum; Martin F Fromm
Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans.
Clinical pharmacology and therapeutics 2004;76(3):230-8.
2004: Mark Hutchinson; Sophie F La Vincente; Andrew A Somogyi
In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance.
Pain 2004;110(3):751-5.
2004: Timothy Mitchell; Jason M White; Andrew A Somogyi; Felix Bochner
Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence.
Addiction (Abingdon, England) 2004;99(8):940-5.
2004: Mark Hutchinson; Andrew A Somogyi
Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation.
European journal of pharmacology 2004;494(2-3):251-62.
2004: David J R Foster; Andrew A Somogyi; Jason M White; Felix Bochner
Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients.
British journal of clinical pharmacology 2004;57(6):742-55.
2004: Benjamin J Davies; Janet K Coller; Heather M James; David Gillis; Andrew A Somogyi; John D Horowitz; Raymond G Morris; Benedetta C Sallustio
Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline.
British journal of clinical pharmacology 2004;57(4):456-63.
2004: Mark Hutchinson; Andrew Menelaou; David J R Foster; Janet K Coller; Andrew A Somogyi
CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.
British journal of clinical pharmacology 2004;57(3):287-97.
2003: Timothy Mitchell; Jason M White; Andrew A Somogyi; Felix Bochner
Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence.
Drug and alcohol dependence 2003;72(1):85-94.
2003: L B Sørensen; R N Sørensen; John O Miners; Andrew A Somogyi; Nick Grgurinovich; Donald J Birkett
Polymorphic hydroxylation of perhexiline in vitro.
British journal of clinical pharmacology 2003;55(6):635-8.
2003: Andrew Menelaou; Mark Hutchinson; Ingvild Quinn; Anders Christensen; Andrew A Somogyi
Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;785(1):81-8.
2002: Mark Hutchinson; Andrew A Somogyi
Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies.
European journal of pharmacology 2002;453(1):27-32.
2002: Ian N Olver; Tim Hercus; Angel Lopez; Matthew Vadas; Andrew A Somogyi; Ian Doyle; David J R Foster; dorothy Keefe; Anne Taylor; Michael Brown; L Bik To; Julie Cole; Trevor Rawling; Bronwyn Cambareri; Melinda Myers; Nancy Olszewski; Stan Bastiras; Carol Senn; Allan Hey; Meera Verma; Peter Wigley
A phase I study of the GM-CSF antagonist E21R.
Cancer chemotherapy and pharmacology 2002;50(3):171-8.
2002: Susan J Porter; Andrew A Somogyi; Jason M White
In vivo and in vitro potency studies of 6beta-naltrexol, the major human metabolite of naltrexone.
Addiction biology 2002;7(2):219-25.
2001: Oliver Von Richter; B Greiner; Martin F Fromm; R Fraser; T Omari; M L Barclay; J Dent; Andrew A Somogyi; Michel Eichelbaum
Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.
Clinical pharmacology and therapeutics 2001;70(3):217-27.
2001: M Chew; Jason M White; Andrew A Somogyi; Felix Bochner; Rodney J Irvine
Precipitated withdrawal following codeine administration is dependent on CYP genotype.
European journal of pharmacology 2001;425(3):159-64.
2001: M Doverty; Andrew A Somogyi; Jason M White; Felix Bochner; C H Beare; Andrew Menelaou; Walter Ling
Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine.
Pain 2001;93(2):155-63.
2001: Kyle R Dyer; Jason M White; David J R Foster; Felix Bochner; Andrew Menelaou; Andrew A Somogyi
The relationship between mood state and plasma methadone concentration in maintenance patients.
Journal of clinical psychopharmacology 2001;21(1):78-84.
2001: M Doverty; Jason M White; Andrew A Somogyi; Felix Bochner; R Ali; Walter Ling
Hyperalgesic responses in methadone maintenance patients.
Pain 2001;90(1-2):91-6.
2000: S J Porter; Andrew A Somogyi; Jason M White
Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol.
British journal of clinical pharmacology 2000;50(5):465-71.
2000: David J R Foster; Andrew A Somogyi; Kyle R Dyer; Jason M White; Felix Bochner
Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.
British journal of clinical pharmacology 2000;50(5):427-40.
2000: David J R Foster; Andrew A Somogyi; Felix Bochner
Stereoselective quantification of methadone and its major oxidative metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, in human urine using high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;744(1):165-76.
2000: JT van Crugten; Andrew A Somogyi; RL Nation
Effect of uranyl nitrate-induced renal failure on morphine disposition and antinociceptive response in rats.
Clinical and experimental pharmacology & physiology 2000;27(1-2):74-9.
1999: Janet K Coller; Andrew A Somogyi; Felix Bochner
Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(10):973-86.
1999: A Malpass; Jason M White; Rodney J Irvine; Andrew A Somogyi; Felix Bochner
Acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA) in Sprague-Dawley and Dark Agouti rats.
Pharmacology, biochemistry, and behavior 1999;64(1):29-34.
1999: Andrew Menelaou; Andrew A Somogyi; M L Barclay; Felix Bochner
Simultaneous quantification of amoxycillin and metronidazole in plasma using high-performance liquid chromatography with photodiode array detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;731(2):261-6.
1999: Janet K Coller; Andrew A Somogyi; Felix Bochner
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.
British journal of clinical pharmacology 1999;48(2):158-67.
1999: Kyle R Dyer; David J R Foster; Jason M White; Andrew A Somogyi; Andrew Menelaou; Felix Bochner
Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: comparison of those who do and do not experience withdrawal and concentration-effect relationships.
Clinical pharmacology and therapeutics 1999;65(6):685-94.
1999: David J R Foster; Andrew A Somogyi; Felix Bochner
Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4.
British journal of clinical pharmacology 1999;47(4):403-12.
1998: Janet K Coller; Andrew A Somogyi; Felix Bochner
Quantification of flunitrazepam's oxidative metabolites, 3-hydroxyflunitrazepam and desmethylflunitrazepam, in hepatic microsomal incubations by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1998;719(1-2):87-92.
1998: LC Kirkwood; Roger L Nation; Andrew A Somogyi
Glucuronidation of dihydrocodeine by human liver microsomes and the effect of inhibitors.
Clinical and experimental pharmacology & physiology 1998;25(3-4):266-70.
1997: LC Kirkwood; Roger L Nation; Andrew A Somogyi
Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine.
British journal of clinical pharmacology 1997;44(6):549-55.
1997: LC Kirkwood; Roger L Nation; Andrew A Somogyi
Determination of the dihydrocodeine metabolites, dihydromorphine and nordihydrocodeine, in hepatic microsomal incubations by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;701(1):129-34.
1997: Robert W Milne; C F McLean; LE Mather; Roger L Nation; William B Runciman; Albert J Rutten; Andrew A Somogyi
Influence of renal failure on the disposition of morphine, morphine-3-glucuronide and morphine-6-glucuronide in sheep during intravenous infusion with morphine.
The Journal of pharmacology and experimental therapeutics 1997;282(2):779-86.
1997: JT van Crugten; Andrew A Somogyi; RL Nation; G Reynolds
The effect of old age on the disposition and antinociceptive response of morphine and morphine-6 beta-glucuronide in the rat.
Pain 1997;71(2):199-205.
1997: Janet K Coller; Andrew A Somogyi; Felix Bochner
Association between CYP2C19 genotype and proguanil oxidative polymorphism.
British journal of clinical pharmacology 1997;43(6):659-60.
1997: JT van Crugten; Andrew A Somogyi; RL Nation; G Reynolds
Concentration-effect relationships of morphine and morphine-6 beta-glucuronide in the rat.
Clinical and experimental pharmacology & physiology 1997;24(5):359-64.
1996: D A Capon; Felix Bochner; N Kerry; Gerd Mikus; C Danz; Andrew A Somogyi
The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.
Clinical pharmacology and therapeutics 1996;60(3):295-307.
1996: Robert W Milne; Roger L Nation; Andrew A Somogyi
The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.
Drug metabolism reviews 1996;28(3):345-472.
1996: Andrew A Somogyi; G Rumrich; G Fritzsch; KJ Ullrich
Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubule.
The Journal of pharmacology and experimental therapeutics 1996;278(1):31-6.
1996: Andrew A Somogyi; H A Reinhard; Felix Bochner
Pharmacokinetic evaluation of proguanil: a probe phenotyping drug for the mephenytoin hydroxylase polymorphism.
British journal of clinical pharmacology 1996;41(3):175-9.
1996: Andrew A Somogyi; H A Reinhard; Felix Bochner
Effects of omeprazole and cimetidine on the urinary metabolic ratio of proguanil in healthy volunteers.
European journal of clinical pharmacology 1996;50(5):417-9.
1995: Robert W Milne; C F McLean; L E Mather; Roger L Nation; William B Runciman; A J Rutten; Andrew A Somogyi
Comparative disposition of morphine-3-glucuronide during separate intravenous infusions of morphine and morphine-3-glucuronide in sheep. Importance of the kidney.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(3):334-42.
1994: N L Kerry; Andrew A Somogyi; Felix Bochner; Gerd Mikus
The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
British journal of clinical pharmacology 1994;38(3):243-8.
1994: Felix Bochner; Andrew A Somogyi; Z R Chen
Dextromethorphan metabolism in rat: interstrain differences and the fate of individually administered oxidative metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(6):543-52.
1994: Andrew A Somogyi; N Simmons; Annette Gross
In-vitro potencies of histamine H2-receptor antagonists on tetraethylammonium uptake in rat renal brush-border membrane vesicles.
The Journal of pharmacy and pharmacology 1994;46(5):375-7.
1994: Annette Gross; Andrew A Somogyi
Interaction of the stereoisomers of basic drugs with the uptake of tetraethylammonium by rat renal brush-border membrane vesicles.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1073-80.
1994: Gerd Mikus; F Bochner; Michel Eichelbaum; P Horak; Andrew A Somogyi; S Spector
Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.
The Journal of pharmacology and experimental therapeutics 1994;268(2):546-51.
1993: Robert W Milne; P A Sloan; C F McLean; L E Mather; Roger L Nation; William B Runciman; A J Rutten; Andrew A Somogyi
Disposition of morphine and its 3- and 6-glucuronide metabolites during morphine infusion in the sheep.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1151-6.
1993: Andrew A Somogyi; Roger L Nation; C Olweny; P Tsirgiotis; J van Crugten; R W Milne; J F Cleary; C Danz; Felix Bochner
Plasma concentrations and renal clearance of morphine, morphine-3-glucuronide and morphine-6-glucuronide in cancer patients receiving morphine.
Clinical pharmacokinetics 1993;24(5):413-20.
1993: N L Kerry; Andrew A Somogyi; Gerd Mikus; Felix Bochner
Primary and secondary oxidative metabolism of dextromethorphan. In vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes.
Biochemical pharmacology 1993;45(4):833-9.
1992: Robert W Milne; Roger L Nation; Andrew A Somogyi; F Bochner; W M Griggs
The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive-care patients.
British journal of clinical pharmacology 1992;34(1):53-9.
1992: Andrew A Somogyi; Felix Bochner; Benedetta C Sallustio
Stereoselective inhibition of pindolol renal clearance by cimetidine in humans.
Clinical pharmacology and therapeutics 1992;51(4):379-87.
1991: Felix Bochner; Andrew A Somogyi; K M Wilson
Bioinequivalence of four 100 mg oral aspirin formulations in healthy volunteers.
Clinical pharmacokinetics 1991;21(5):394-9.
1991: Gerd Mikus; Andrew A Somogyi; Felix Bochner; M Eichelbaum
Thebaine O-demethylation to oripavine: genetic differences between two rat strains.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(11):1501-9.
1991: J T Van Crugten; Benedetta C Sallustio; Roger L Nation; Andrew A Somogyi
Renal tubular transport of morphine, morphine-6-glucuronide, and morphine-3-glucuronide in the isolated perfused rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(6):1087-92.
1991: P A Sloan; L E Mather; C F McLean; A J Rutten; Roger L Nation; Robert W Milne; William B Runciman; Andrew A Somogyi
Physiological disposition of i.v. morphine in sheep.
British journal of anaesthesia 1991;67(4):378-86.
1991: R W Milne; Roger L Nation; G D Reynolds; Andrew A Somogyi; J T Van Crugten
High-performance liquid chromatographic determination of morphine and its 3- and 6-glucuronide metabolites: improvements to the method and application to stability studies.
Journal of chromatography 1991;565(1-2):457-64.
1991: Z R Chen; Andrew A Somogyi; G Reynolds; Felix Bochner
Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.
British journal of clinical pharmacology 1991;31(4):381-90.
1991: Gerd Mikus; Andrew A Somogyi; Felix Bochner; M Eichelbaum
Codeine O-demethylation: rat strain differences and the effects of inhibitors.
Biochemical pharmacology 1991;41(5):757-62.
1991: M R Muirhead; Andrew A Somogyi
Effect of H2 antagonists on the differential secretion of triamterene and its sulfate conjugate metabolite by the isolated perfused rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):312-6.
1991: Allan M Evans; Roger L Nation; Lloyd Sansom; F Bochner; Andrew A Somogyi
Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen.
British journal of clinical pharmacology 1991;31(2):131-8.
1991: Gerd Mikus; Andrew A Somogyi; Felix Bochner; Z R Chen
Polymorphic metabolism of opioid narcotic drugs: possible clinical implications.
Annals of the Academy of Medicine, Singapore 1991;20(1):9-12.
1991: Z R Chen; Rodney J Irvine; Andrew A Somogyi; Felix Bochner
Mu receptor binding of some commonly used opioids and their metabolites.
Life sciences 1991;48(22):2165-71.
1990: Allan M Evans; Roger L Nation; Lloyd Sansom; F Bochner; Andrew A Somogyi
The relationship between the pharmacokinetics of ibuprofen enantiomers and the dose of racemic ibuprofen in humans.
Biopharmaceutics & drug disposition 1990;11(6):507-18.
1990: K M Wilson; D M Siebert; Elizabeth M Duncan; Andrew A Somogyi; John V Lloyd; Felix Bochner
Effect of aspirin infusions on platelet function in humans.
Clinical science (London, England : 1979) 1990;79(1):37-42.
1990: Z R Chen; Rodney J Irvine; Felix Bochner; Andrew A Somogyi
Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia.
Life sciences 1990;46(15):1067-74.
1990: Z R Chen; Andrew A Somogyi; Felix Bochner
Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man.
Therapeutic drug monitoring 1990;12(1):97-104.
1989: M R Muirhead; Andrew A Somogyi; C Lloyd; Felix Bochner
Deconjugation of p-hydroxytriamterene sulphate in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1989;19(6):655-60.
1989: Andrew A Somogyi; C M Hovens; M R Muirhead; Felix Bochner
Renal tubular secretion of amiloride and its inhibition by cimetidine in humans and in an animal model.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(2):190-6.
1989: Allan M Evans; Roger L Nation; Lloyd Sansom; F Bochner; Andrew A Somogyi
Stereoselective plasma protein binding of ibuprofen enantiomers.
European journal of clinical pharmacology 1989;36(3):283-90.
1988: Allan M Evans; Roger L Nation; Lloyd Sansom; F Bochner; Andrew A Somogyi
Stereoselective drug disposition: potential for misinterpretation of drug disposition data.
British journal of clinical pharmacology 1988;26(6):771-80.
1988: Z R Chen; Andrew A Somogyi; Felix Bochner
Polymorphic O-demethylation of codeine.
Lancet 1988;2(8616):914-5.
1988: Z R Chen; D M Siebert; Andrew A Somogyi; Felix Bochner
Determination of pholcodine in biological fluids by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1988;424(1):170-6.
1986: M R Muirhead; Andrew A Somogyi; P E Rolan; Felix Bochner
Effect of cimetidine on renal and hepatic drug elimination: studies with triamterene.
Clinical pharmacology and therapeutics 1986;40(4):400-7.