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John Sondek

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Friedman Erin J; Temple Brenda R S; Hicks Stephanie N; Sondek John; Jones Corbin D; Jones Alan M
Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain.
Harden T Kendall; Hicks Stephanie N; Sondek John
Phospholipase C isozymes as effectors of Ras superfamily GTPases.
Evelyn Chris R; Ferng Timothy; Rojas Rafael J; Larsen Martha J; Sondek John; Neubig Richard R
High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.

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All Publications

2009: Friedman Erin J; Temple Brenda R S; Hicks Stephanie N; Sondek John; Jones Corbin D; Jones Alan M
Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain.
Journal of molecular biology 2009;392(4):1044-54.
2009: Harden T Kendall; Hicks Stephanie N; Sondek John
Phospholipase C isozymes as effectors of Ras superfamily GTPases.
Journal of lipid research 2009;50 Suppl():S243-8.
2009: Evelyn Chris R; Ferng Timothy; Rojas Rafael J; Larsen Martha J; Sondek John; Neubig Richard R
High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2009;14(2):161-72.
2008: Seifert Jason P; Zhou Yixing; Hicks Stephanie N; Sondek John; Harden T Kendall
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases.
The Journal of biological chemistry 2008;283(44):29690-8.
2008: Hicks Stephanie N; Jezyk Mark R; Gershburg Svetlana; Seifert Jason P; Harden T Kendall; Sondek John
General and versatile autoinhibition of PLC isozymes.
Molecular cell 2008;31(3):383-94.
2008: Yohe Marielle E; Rossman Kent; Sondek John
Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.
Biochemistry 2008;47(26):6827-39.
2008: Zhou Yixing; Sondek John; Harden T Kendall
Activation of human phospholipase C-eta2 by Gbetagamma.
Biochemistry 2008;47(15):4410-7.
2008: Cheever Matthew L; Snyder Jason T; Gershburg Svetlana; Siderovski David P; Harden T Kendall; Sondek John
Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nature structural & molecular biology 2008;15(2):155-62.
2008: Valeyev Najl V; Downing A Kristina; Sondek John; Deane Charlotte
Electrostatic and Functional Analysis of the Seven-Bladed WD beta-Propellers.
Evolutionary bioinformatics online 2008;4():203-16.
2007: Rojas Rafael J; Yohe Marielle E; Gershburg Svetlana; Kawano Takeharu; Kozasa Tohru; Sondek John
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.
The Journal of biological chemistry 2007;282(40):29201-10.
2007: Mitin Natalia; Betts Laurie; Yohe Marielle E; Der Channing J; Sondek John; Rossman Kent L
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nature structural & molecular biology 2007;14(9):814-23.
2007: Chhatriwala Mariya K; Betts Laurie; Worthylake David K; Sondek John
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.
Journal of molecular biology 2007;368(5):1307-20.
2007: Yohe Marielle E; Rossman Kent L; Gardner Olivia S; Karnoub Antoine E; Snyder Jason T; Gershburg Svetlana; Graves Lee M; Der Channing J; Sondek John
Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.
The Journal of biological chemistry 2007;282(18):13813-23.
2007: Desveaux Darrell; Singer Alex U; Wu Ai-Jiuan; McNulty Brian C; Musselwhite Laura; Nimchuk Zachary; Sondek John; Dangl Jeffery L
Type III effector activation via nucleotide binding, phosphorylation, and host target interaction.
PLoS pathogens 2007;3(3):e48.
2007: Bencharit Sompop; Cui Cai Bin; Siddiqui Adnan; Howard-Williams Escher L; Sondek John; Zuobi-Hasona Kheir; Aukhil Ikramuddin
Structural insights into fibronectin type III domain-mediated signaling.
Journal of molecular biology 2007;367(2):303-9.
2006: Jezyk Mark R; Snyder Jason T; Gershberg Svetlana; Worthylake David K; Harden T Kendall; Sondek John
Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nature structural & molecular biology 2006;13(12):1135-40.
2006: Baumeister Mark A; Rossman Kent L; Sondek John; Lemmon Mark A
The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.
The Biochemical journal 2006;400(3):563-72.
2006: Bourdon David M; Wing Michele R; Edwards Earl B; Sondek John; Harden T Kendall
Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system.
Methods in enzymology 2006;406():489-99.
2006: Snyder Jason T; Jezyk Mark R; Gershburg Svetlana; Harden T Kendall; Sondek John
Regulation of PLCbeta isoforms by Rac.
Methods in enzymology 2006;406():272-80.
2006: Seifert Jason P; Snyder Jason T; Sondek John; Harden T Kendall
Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles.
Methods in enzymology 2006;406():260-71.
2006: Harden T Kendall; Sondek John
Regulation of phospholipase C isozymes by ras superfamily GTPases.
Annual review of pharmacology and toxicology 2006;46():355-79.
2005: Zhou Yixing; Wing Michele R; Sondek John; Harden T Kendall
Molecular cloning and characterization of PLC-eta2.
The Biochemical journal 2005;391(Pt 3):667-76.
2005: Smith William J; Hamel Brant; Yohe Marielle E; Sondek John; Cerione Richard A; Snyder Jason T
A Cdc42 mutant specifically activated by intersectin.
Biochemistry 2005;44(40):13282-90.
2005: Johnston Christopher A; Willard Francis S; Jezyk Mark R; Fredericks Zoey; Bodor Erik T; Jones Miller B; Blaesius Rainer; Watts Val J; Harden T Kendall; Sondek John; Ramer J Kevin; Siderovski David P
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.
Structure (London, England : 1993) 2005;13(7):1069-80.
2005: Kim Han-Suk; Desveaux Darrell; Singer Alex U; Patel Priyesh; Sondek John; Dangl Jeffery L
The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6496-501.
2005: Rossman Kent L; Sondek John
Larger than Dbl: new structural insights into RhoA activation.
Trends in biochemical sciences 2005;30(4):163-5.
2005: Gentry Holly R; Singer Alex U; Betts Laurie; Yang Cheng; Ferrara Joseph D; Sondek John; Parise Leslie V
Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.
The Journal of biological chemistry 2005;280(9):8407-15.
2005: Lu Mingjian; Kinchen Jason M; Rossman Kent L; Grimsley Cynthia; Hall Matthew; Sondek John; Hengartner Michael O; Yajnik Vijay; Ravichandran Kodi S
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Current biology : CB 2005;15(4):371-7.
2005: Rossman Kent L; Der Channing J; Sondek John
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
Nature reviews. Molecular cell biology 2005;6(2):167-80.
2004: deBakker Colin D; Haney Lisa B; Kinchen Jason M; Grimsley Cynthia; Lu Mingjian; Klingele Doris; Hsu Pei-Ken; Chou Bin-Kuan; Cheng Li-Chun; Blangy Anne; Sondek John; Hengartner Michael O; Wu Yi-Chun; Ravichandran Kodi S
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.
Current biology : CB 2004;14(24):2208-16.
2004: Singh Anurag; Karnoub Antoine E; Palmby Todd R; Lengyel Ernst; Sondek John; Der Channing J
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
Oncogene 2004;23(58):9369-80.
2004: Seifert Jason P; Wing Michele R; Snyder Jason T; Gershburg Svetlana; Sondek John; Harden T Kendall
RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism.
The Journal of biological chemistry 2004;279(46):47992-7.
2004: Kimple Michelle E; Sondek John
Overview of affinity tags for protein purification.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 9():Unit 9.9.
2004: Singer Alex U; Desveaux Darrell; Betts Laurie; Chang Jeff H; Nimchuk Zachary; Grant Sarah R; Dangl Jeffery L; Sondek John
Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis.
Structure (London, England : 1993) 2004;12(9):1669-81.
2004: Lu Mingjian; Kinchen Jason M; Rossman Kent L; Grimsley Cynthia; deBakker Colin; Brugnera Enrico; Tosello-Trampont Annie-Carole; Haney Lisa B; Klingele Doris; Sondek John; Hengartner Michael O; Ravichandran Kodi S
PH domain of ELMO functions in trans to regulate Rac activation via Dock180.
Nature structural & molecular biology 2004;11(8):756-62.
2004: Worthylake David K; Rossman Kent L; Sondek John
Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure (London, England : 1993) 2004;12(6):1078-86.
2004: Solski Patricia A; Wilder Rhonda S; Rossman Kent L; Sondek John; Cox Adrienne D; Campbell Sharon L; Der Channing J
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.
The Journal of biological chemistry 2004;279(24):25226-33.
2004: Chen Yi; Vallee Sebastien; Wu Joann; Vu Don; Sondek John; Ghosh Gourisankar
Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras.
Molecular and cellular biology 2004;24(7):3048-56.
2003: Salazar Marco A; Kwiatkowski Adam V; Pellegrini Lorenzo; Cestra Gianluca; Butler Margaret H; Rossman Kent L; Serna Daniel M; Sondek John; Gertler Frank B; De Camilli Pietro
Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.
The Journal of biological chemistry 2003;278(49):49031-43.
2003: Wing Michele R; Snyder Jason T; Sondek John; Harden T Kendall
Direct activation of phospholipase C-epsilon by Rho.
The Journal of biological chemistry 2003;278(42):41253-8.
2003: Rojas Rafael J; Kimple Randall J; Rossman Kent L; Siderovski David P; Sondek John
Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases.
Combinatorial chemistry & high throughput screening 2003;6(4):409-18.
2003: Snyder Jason T; Singer Alex U; Wing Michele R; Harden T Kendall; Sondek John
The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.
The Journal of biological chemistry 2003;278(23):21099-104.
2003: Rossman Kent L; Cheng Li; Mahon Gwendolyn M; Rojas Rafael J; Snyder Jason T; Whitehead Ian P; Sondek John
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation.
The Journal of biological chemistry 2003;278(20):18393-400.
2003: Pruitt Wendy M; Karnoub Antoine E; Rakauskas A Corinne; Guipponi Michel; Antonarakis Stylianos E; Kurakin Alexei; Kay Brian K; Sondek John; Siderovski David P; Der Channing J
Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling.
Biochimica et biophysica acta 2003;1640(1):61-8.
2003: Baumeister Mark A; Martinu Lenka; Rossman Kent L; Sondek John; Lemmon Mark A; Chou Margaret M
Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting.
The Journal of biological chemistry 2003;278(13):11457-64.
2002: Rossman Kent L; Worthylake David K; Snyder Jason T; Cheng Li; Whitehead Ian P; Sondek John
Functional analysis of cdc42 residues required for Guanine nucleotide exchange.
The Journal of biological chemistry 2002;277(52):50893-8.
2002: Cheng Li; Rossman Kent L; Mahon Gwendolyn M; Worthylake David K; Korus Malgorzata; Sondek John; Whitehead Ian P
RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.
Molecular and cellular biology 2002;22(19):6895-905.
2002: Kimple Michelle E; Sondek John
Affinity tag for protein purification and detection based on the disulfide-linked complex of InaD and NorpA.
BioTechniques 2002;33(3):578, 580, 584-8 passim.
2002: Lambert John M; Lambert Que T; Reuther Gary W; Malliri Angeliki; Siderovski David P; Sondek John; Collard John G; Der Channing J
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
Nature cell biology 2002;4(8):621-5.
2002: Barry William T; Boudignon-Proudhon Christel; Shock David D; McFadden Andrew; Weiss Jonathan M; Sondek John; Parise Leslie V
Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.
The Journal of biological chemistry 2002;277(32):28877-83.
2002: Snyder Jason T; Worthylake David K; Rossman Kent L; Betts Laurie; Pruitt Wendy M; Siderovski David P; Der Channing J; Sondek John
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nature structural biology 2002;9(6):468-75.
2002: Kimple Randall J; Kimple Michelle E; Betts Laurie; Sondek John; Siderovski David P
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature 2002;416(6883):878-81.
2002: Rossman Kent L; Worthylake David K; Snyder Jason T; Siderovski David P; Campbell Sharon L; Sondek John
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
The EMBO journal 2002;21(6):1315-26.
2002: Singer Alex U; Waldo Gary L; Harden T Kendall; Sondek John
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.
Nature structural biology 2002;9(1):32-6.
2002: Siderovski David P; Snow Bryan E; Chung Stephen; Brothers Greg M; Sondek John; Betts Laurie
Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits.
Methods in enzymology 2002;344():702-23.
2001: Karnoub A E; Worthylake D K; Rossman K L; Pruitt W M; Campbell S L; Sondek J; Der C J
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.
Nature structural biology 2001;8(12):1037-41.
2001: Snyder J T; Rossman K L; Baumeister M A; Pruitt W M; Siderovski D P; Der C J; Lemmon M A; Sondek J
Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins.
The Journal of biological chemistry 2001;276(49):45868-75.
2001: Kimple M E; Siderovski D P; Sondek J
Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
The EMBO journal 2001;20(16):4414-22.
2001: Reuther G W; Lambert Q T; Booden M A; Wennerberg K; Becknell B; Marcucci G; Sondek J; Caligiuri M A; Der C J
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.
The Journal of biological chemistry 2001;276(29):27145-51.
2001: Sondek J; Siderovski D P
Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.
Biochemical pharmacology 2001;61(11):1329-37.
2000: Worthylake D K; Rossman K L; Sondek J
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature 2000;408(6813):682-8.
1999: Shock D D; Naik U P; Brittain J E; Alahari S K; Sondek J; Parise L V
Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton.
The Biochemical journal 1999;342 Pt 3():729-35.
1999: Snow B E; Betts L; Mangion J; Sondek J; Siderovski D P
Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6489-94.

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