Nahum Sonenberg

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Physiology

Protein Biosynthesis

Chemicals & Drugs

Anatomy

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Publications

TOP 3
Fabian Marc R; Sundermeier Thomas R; Sonenberg Nahum
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression.
Petroulakis Emmanuel; Parsyan Armen; Dowling Ryan J O; LeBacquer Olivier; Martineau Yvan; Bidinosti Michael; Larsson Ola; Alain Tommy; Rong Liwei; Mamane Yaël; Paquet Marilene; Furic Luc; Topisirovic Ivan; Shahbazian David; Livingstone Mark; Costa-Mattioli Mauro; Teodoro Jose G; Sonenberg Nahum
p53-dependent translational control of senescence and transformation via 4E-BPs.
Panja Debabrata; Dagyte Girstaute; Bidinosti Michael; Wibrand Karin; Kristiansen Ase-Marit; Sonenberg Nahum; Bramham Clive R
Novel translational control in Arc-dependent long term potentiation consolidation in vivo.

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All Publications

2010: Fabian Marc R; Sundermeier Thomas R; Sonenberg Nahum
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression.
Progress in molecular and subcellular biology 2010;50():1-20.
2009: Petroulakis Emmanuel; Parsyan Armen; Dowling Ryan J O; LeBacquer Olivier; Martineau Yvan; Bidinosti Michael; Larsson Ola; Alain Tommy; Rong Liwei; Mamane Yaël; Paquet Marilene; Furic Luc; Topisirovic Ivan; Shahbazian David; Livingstone Mark; Costa-Mattioli Mauro; Teodoro Jose G; Sonenberg Nahum
p53-dependent translational control of senescence and transformation via 4E-BPs.
Cancer cell 2009;16(5):439-46.
2009: Panja Debabrata; Dagyte Girstaute; Bidinosti Michael; Wibrand Karin; Kristiansen Ase-Marit; Sonenberg Nahum; Bramham Clive R
Novel translational control in Arc-dependent long term potentiation consolidation in vivo.
The Journal of biological chemistry 2009;284(46):31498-511.
2009: Kanaan Ahmad Seif; Frank Filipp; Maedler-Kron Chelsea; Verma Karan; Sonenberg Nahum; Nagar Bhushan
Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 10):1060-4.
2009: Fabian Marc R; Mathonnet Géraldine; Sundermeier Thomas; Mathys Hansruedi; Zipprich Jakob T; Svitkin Yuri V; Rivas Fabiola; Jinek Martin; Wohlschlegel James; Doudna Jennifer A; Chen Chyi-Ying A; Shyu Ann-Bin; Yates John R; Hannon Gregory J; Filipowicz Witold; Duchaine Thomas F; Sonenberg Nahum
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
Molecular cell 2009;35(6):868-80.
2009: Olson Katie E; Booth Garrett C; Poulin Francis; Sonenberg Nahum; Beretta Laura
Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2.
Immunology 2009;128(1 Suppl):e376-84.
2009: Ran Israeli; Laplante Isabel; Bourgeois Catherine; Pépin Julie; Lacaille Philippe; Costa-Mattioli Mauro; Pelletier Jerry; Sonenberg Nahum; Lacaille Jean-Claude
Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(17):5605-15.
2009: Yanagiya Akiko; Svitkin Yuri V; Shibata Shoichiro; Mikami Satoshi; Imataka Hiroaki; Sonenberg Nahum
Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.
Molecular and cellular biology 2009;29(6):1661-9.
2009: Sonenberg Nahum; Hinnebusch Alan G
Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
Cell 2009;136(4):731-45.
2009: Marintchev Assen; Edmonds Katherine A; Marintcheva Boriana; Hendrickson Elthea; Oberer Monika; Suzuki Chikako; Herdy Barbara; Sonenberg Nahum; Wagner Gerhard
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.
Cell 2009;136(3):447-60.
2009: Costa-Mattioli Mauro; Sossin Wayne S; Klann Eric; Sonenberg Nahum
Translational control of long-lasting synaptic plasticity and memory.
Neuron 2009;61(1):10-26.
2009: Svitkin Yuri V; Evdokimova Valentina M; Brasey Ann; Pestova Tatyana V; Fantus Daniel; Yanagiya Akiko; Imataka Hiroaki; Skabkin Maxim A; Ovchinnikov Lev P; Merrick William C; Sonenberg Nahum
General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation.
The EMBO journal 2009;28(1):58-68.
2009: Brenet F; Socci N D; Sonenberg N; Holland E C
Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.
Oncogene 2009;28(1):128-39.
2009: Dowling Ryan J O; Pollak Michael; Sonenberg Nahum
Current status and challenges associated with targeting mTOR for cancer therapy.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2009;23(2):77-91.
2009: Santhanam Arti N; Bindewald Eckart; Rajasekhar Vinagolu K; Larsson Ola; Sonenberg Nahum; Colburn Nancy H; Shapiro Bruce A
Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.
PloS one 2009;4(3):e4868.
2008: Martineau Yvan; Derry Mélanie C; Wang Xiaoshan; Yanagiya Akiko; Berlanga Juan José; Shyu Ann-Bin; Imataka Hiroaki; Gehring Kalle; Sonenberg Nahum
Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.
Molecular and cellular biology 2008;28(21):6658-67.
2008: Zakikhani Mahvash; Dowling Ryan J O; Sonenberg Nahum; Pollak Michael N
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.
Cancer prevention research (Philadelphia, Pa.) 2008;1(5):369-75.
2008: Costa-Mattioli Mauro; Sonenberg Nahum
RAPping production of type I interferon in pDCs through mTOR.
Nature immunology 2008;9(10):1097-9.
2008: Aizer Adva; Brody Yehuda; Ler Lian Wee; Sonenberg Nahum; Singer Robert H; Shav-Tal Yaron
The dynamics of mammalian P body transport, assembly, and disassembly in vivo.
Molecular biology of the cell 2008;19(10):4154-66.
2008: Napoli Ilaria; Mercaldo Valentina; Boyl Pietro Pilo; Eleuteri Boris; Zalfa Francesca; De Rubeis Silvia; Di Marino Daniele; Mohr Evita; Massimi Marzia; Falconi Mattia; Witke Walter; Costa-Mattioli Mauro; Sonenberg Nahum; Achsel Tilmann; Bagni Claudia
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.
Cell 2008;134(6):1042-54.
2008: Rong Liwei; Livingstone Mark; Sukarieh Rami; Petroulakis Emmanuel; Gingras Anne-Claude; Crosby Katherine; Smith Bradley; Polakiewicz Roberto D; Pelletier Jerry; Ferraiuolo Maria A; Sonenberg Nahum
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.
RNA (New York, N.Y.) 2008;14(7):1318-27.
2008: Oliere Stephanie; Arguello Meztli; Mesplede Thibault; Tumilasci Vanessa; Nakhaei Peyman; Stojdl David; Sonenberg Nahum; Bell John; Hiscott John
Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.
Journal of virology 2008;82(12):5735-49.
2008: Sonenberg Nahum
eIF4E, the mRNA cap-binding protein: from basic discovery to translational research.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2008;86(2):178-83.
2008: Yamaguchi Suguru; Ishihara Hisamitsu; Yamada Takahiro; Tamura Akira; Usui Masahiro; Tominaga Ryu; Munakata Yuichiro; Satake Chihiro; Katagiri Hideki; Tashiro Fumi; Aburatani Hiroyuki; Tsukiyama-Kohara Kyoko; Miyazaki Jun-ichi; Sonenberg Nahum; Oka Yoshitomo
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.
Cell metabolism 2008;7(3):269-76.
2008: Colina Rodney; Costa-Mattioli Mauro; Dowling Ryan J O; Jaramillo Maritza; Tai Lee-Hwa; Breitbach Caroline J; Martineau Yvan; Larsson Ola; Rong Liwei; Svitkin Yuri V; Makrigiannis Andrew P; Bell John C; Sonenberg Nahum
Translational control of the innate immune response through IRF-7.
Nature 2008;452(7185):323-8.
2008: Filipowicz Witold; Bhattacharyya Suvendra N; Sonenberg Nahum
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Nature reviews. Genetics 2008;9(2):102-14.
2008: Costa-Mattioli Mauro; Sonenberg Nahum
Translational control of gene expression: a molecular switch for memory storage.
Progress in brain research 2008;169():81-95.
2007: Sonenberg Nahum; Hinnebusch Alan G
New modes of translational control in development, behavior, and disease.
Molecular cell 2007;28(5):721-9.
2007: Svitkin Yuri V; Costa-Mattioli Mauro; Herdy Barbara; Perreault Sandra; Sonenberg Nahum
Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP).
RNA (New York, N.Y.) 2007;13(12):2330-40.
2007: Dowling Ryan J O; Zakikhani Mahvash; Fantus I George; Pollak Michael; Sonenberg Nahum
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.
Cancer research 2007;67(22):10804-12.
2007: Lee Chung-Han; Inoki Ken; Karbowniczek Magdalena; Petroulakis Emmanuel; Sonenberg Nahum; Henske Elizabeth Petri; Guan Kun-Liang
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.
The EMBO journal 2007;26(23):4812-23.
2007: Burgui Idoia; Yángüez Emilio; Sonenberg Nahum; Nieto Amelia
Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?
Journal of virology 2007;81(22):12427-38.
2007: Mathonnet Géraldine; Fabian Marc R; Svitkin Yuri V; Parsyan Armen; Huck Laurent; Murata Takayuki; Biffo Stefano; Merrick William C; Darzynkiewicz Edward; Pillai Ramesh S; Filipowicz Witold; Duchaine Thomas F; Sonenberg Nahum
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F.
Science (New York, N.Y.) 2007;317(5845):1764-7.
2007: Gelinas Jennifer N; Banko Jessica L; Hou Lingfei; Sonenberg Nahum; Weeber Edwin J; Klann Eric; Nguyen Peter V
ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation.
The Journal of biological chemistry 2007;282(37):27527-35.
2007: Masutani Mamiko; Sonenberg Nahum; Yokoyama Shigeyuki; Imataka Hiroaki
Reconstitution reveals the functional core of mammalian eIF3.
The EMBO journal 2007;26(14):3373-83.
2007: Zuberek Joanna; Kubacka Dorota; Jablonowska Agnieszka; Jemielity Jacek; Stepinski Janusz; Sonenberg Nahum; Darzynkiewicz Edward
Weak binding affinity of human 4EHP for mRNA cap analogs.
RNA (New York, N.Y.) 2007;13(5):691-7.
2007: Roux Philippe P; Shahbazian David; Vu Hieu; Holz Marina K; Cohen Michael S; Taunton Jack; Sonenberg Nahum; Blenis John
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
The Journal of biological chemistry 2007;282(19):14056-64.
2007: Hu Jing; Straub Jonathan; Xiao Dong; Singh Shivendra V; Yang Hsin-Sheng; Sonenberg Nahum; Vatsyayan Jaya
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
Cancer research 2007;67(8):3569-73.
2007: Costa-Mattioli Mauro; Gobert Delphine; Stern Elad; Gamache Karine; Colina Rodney; Cuello Claudio; Sossin Wayne; Kaufman Randal; Pelletier Jerry; Rosenblum Kobi; Krnjevic Kresimir; Lacaille Jean-Claude; Nader Karim; Sonenberg Nahum
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Cell 2007;129(1):195-206.
2007: Wilker Erik W; van Vugt Marcel A T M; Artim Steven A; Huang Paul H; Petersen Christian P; Reinhardt H Christian; Feng Yun; Sharp Phillip A; Sonenberg Nahum; White Forest M; Yaffe Michael B
14-3-3sigma controls mitotic translation to facilitate cytokinesis.
Nature 2007;446(7133):329-32.
2007: Lasko Paul; Sonenberg Nahum
Coordinated transcriptional and translational control in metabolic homeostasis in flies.
Genes & development 2007;21(3):235-7.
2007: Le Bacquer Olivier; Petroulakis Emmanuel; Paglialunga Sabina; Poulin Francis; Richard Denis; Cianflone Katherine; Sonenberg Nahum
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.
The Journal of clinical investigation 2007;117(2):387-96.
2007: Banko Jessica L; Merhav Maayan; Stern Elad; Sonenberg Nahum; Rosenblum Kobi; Klann Eric
Behavioral alterations in mice lacking the translation repressor 4E-BP2.
Neurobiology of learning and memory 2007;87(2):248-56.
2007: Kaur Surinder; Lal Lakhvir; Sassano Antonella; Majchrzak-Kita Beata; Srikanth Maya; Baker Darren P; Petroulakis Emmanuel; Hay Nissim; Sonenberg Nahum; Fish Eleanor N; Platanias Leonidas C
Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling.
The Journal of biological chemistry 2007;282(3):1757-68.
2007: Svitkin Yuri V; Sonenberg Nahum
A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus RNA genomes.
Methods in enzymology 2007;429():53-82.
2007: Petroulakis E; Mamane Y; Le Bacquer O; Shahbazian D; Sonenberg N
mTOR signaling: implications for cancer and anticancer therapy.
British journal of cancer 2007;96 Suppl():R11-5.
2007: Mamane Yaël; Petroulakis Emmanuel; Martineau Yvan; Sato Taka-Aki; Larsson Ola; Rajasekhar Vinagolu K; Sonenberg Nahum
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation.
PloS one 2007;2(2):e242.
2006: Kanhema Tambudzai; Dagestad Grethe; Panja Debabrata; Tiron Adrian; Messaoudi Elhoucine; Håvik Bjarte; Ying Shui-Wang; Nairn Angus C; Sonenberg Nahum; Bramham Clive R
Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.
Journal of neurochemistry 2006;99(5):1328-37.
2006: Zakikhani Mahvash; Dowling Ryan; Fantus I George; Sonenberg Nahum; Pollak Michael
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells.
Cancer research 2006;66(21):10269-73.
2006: Khanam Tasneem; Muddashetty Ravi Sondekoppa; Kahvejian Avak; Sonenberg Nahum; Brosius Juergen
Poly(A)-binding protein binds to A-rich sequences via RNA-binding domains 1+2 and 3+4.
RNA biology 2006;3(4):170-7.
2006: Cho Park F; Gamberi Chiara; Cho-Park Yoon Andrew; Cho-Park Ian B; Lasko Paul; Sonenberg Nahum
Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos.
Current biology : CB 2006;16(20):2035-41.
2006: Sonenberg Nahum; Pause Arnim
Signal transduction. Protein synthesis and oncogenesis meet again.
Science (New York, N.Y.) 2006;314(5798):428-9.
2006: Mamane Y; Petroulakis E; LeBacquer O; Sonenberg N
mTOR, translation initiation and cancer.
Oncogene 2006;25(48):6416-22.
2006: Miyakawa Shin; Oguro Akihiro; Ohtsu Takashi; Imataka Hiroaki; Sonenberg Nahum; Nakamura Yoshikazu
RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes.
RNA (New York, N.Y.) 2006;12(10):1825-34.
2006: Berlanga Juan José; Baass Alexis; Sonenberg Nahum
Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.
RNA (New York, N.Y.) 2006;12(8):1556-68.
2006: Svitkin Yuri V; Sonenberg Nahum
[Translational control by the poly(A) binding protein: a check for mRNA integrity]
Molekuliarnaia biologiia 2006;40(4):684-93.
2006: Karim Muhammad M; Svitkin Yuri V; Kahvejian Avak; De Crescenzo Gregory; Costa-Mattioli Mauro; Sonenberg Nahum
A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9494-9.
2006: Shahbazian David; Roux Philippe P; Mieulet Virginie; Cohen Michael S; Raught Brian; Taunton Jack; Hershey John W B; Blenis John; Pende Mario; Sonenberg Nahum
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
The EMBO journal 2006;25(12):2781-91.
2006: Broxmeyer Hal E; Ginras Anne-Claude; Sonenberg Nahum; Cooper Scott
Retraction. Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1.
Blood 2006;107(12):4713.
2006: Bellsolell Lluís; Cho-Park Park F; Poulin Francis; Sonenberg Nahum; Burley Stephen K
Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.
Structure (London, England : 1993) 2006;14(5):913-23.
2006: Yoshida Madoka; Yoshida Kaori; Kozlov Guennadi; Lim Nadia S; De Crescenzo Gregory; Pang Zhiyu; Berlanga Juan Jose; Kahvejian Avak; Gehring Kalle; Wing Simon S; Sonenberg Nahum
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2.
The EMBO journal 2006;25(9):1934-44.
2006: Berlanga Juan J; Ventoso Iván; Harding Heather P; Deng Jing; Ron David; Sonenberg Nahum; Carrasco Luis; de Haro César
Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses.
The EMBO journal 2006;25(8):1730-40.
2006: Mikami Satoshi; Masutani Mamiko; Sonenberg Nahum; Yokoyama Shigeyuki; Imataka Hiroaki
An efficient mammalian cell-free translation system supplemented with translation factors.
Protein expression and purification 2006;46(2):348-57.
2006: Koritzinsky Marianne; Magagnin Michaël G; van den Beucken Twan; Seigneuric Renaud; Savelkouls Kim; Dostie Josée; Pyronnet Stéphane; Kaufman Randal J; Weppler Sherry A; Voncken Jan Willem; Lambin Philippe; Koumenis Constantinos; Sonenberg Nahum; Wouters Bradly G
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.
The EMBO journal 2006;25(5):1114-25.
2006: Banko Jessica L; Hou Lingfei; Poulin Francis; Sonenberg Nahum; Klann Eric
Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(8):2167-73.
2006: Petroulakis E; Mamane Y; Le Bacquer O; Shahbazian D; Sonenberg N
mTOR signaling: implications for cancer and anticancer therapy.
British journal of cancer 2006;94(2):195-9.
2006: Evdokimova Valentina; Ruzanov Peter; Anglesio Michael S; Sorokin Alexey V; Ovchinnikov Lev P; Buckley Jonathan; Triche Timothy J; Sonenberg Nahum; Sorensen Poul H B
Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.
Molecular and cellular biology 2006;26(1):277-92.
2006: Costa-Mattioli Mauro; Sonenberg Nahum
Translational control of long-term synaptic plasticity and memory storage by eIF2alpha.
Critical reviews in neurobiology 2006;18(1-2):187-95.
2006: Derry M C; Yanagiya A; Martineau Y; Sonenberg N
Regulation of poly(A)-binding protein through PABP-interacting proteins.
Cold Spring Harbor symposia on quantitative biology 2006;71():537-43.
2005: Svitkin Yuri V; Herdy Barbara; Costa-Mattioli Mauro; Gingras Anne-Claude; Raught Brian; Sonenberg Nahum
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation.
Molecular and cellular biology 2005;25(23):10556-65.
2005: Lasko P; Cho P; Poulin F; Sonenberg N
Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5'-cap structure binding.
Biochemical Society transactions 2005;33(Pt 6):1544-6.
2005: Ruggero Davide; Sonenberg Nahum
The Akt of translational control.
Oncogene 2005;24(50):7426-34.
2005: Gingras Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
Molecular & cellular proteomics : MCP 2005;4(11):1725-40.
2005: Banko Jessica L; Poulin Francis; Hou Lingfei; DeMaria Christine T; Sonenberg Nahum; Klann Eric
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(42):9581-90.
2005: Ferraiuolo Maria A; Basak Sanjukta; Dostie Josee; Murray Elizabeth L; Schoenberg Daniel R; Sonenberg Nahum
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.
The Journal of cell biology 2005;170(6):913-24.
2005: Hahn-Windgassen Annett; Nogueira Veronique; Chen Chia-Chen; Skeen Jennifer E; Sonenberg Nahum; Hay Nissim
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.
The Journal of biological chemistry 2005;280(37):32081-9.
2005: Costa-Mattioli Mauro; Gobert Delphine; Harding Heather; Herdy Barbara; Azzi Mounia; Bruno Martin; Bidinosti Michael; Ben Mamou Cyrinne; Marcinkiewicz Edwige; Yoshida Madoka; Imataka Hiroaki; Cuello A Claudio; Seidah Nabil; Sossin Wayne; Lacaille Jean-Claude; Ron David; Nader Karim; Sonenberg Nahum
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.
Nature 2005;436(7054):1166-73.
2005: Tettweiler Gritta; Miron Mathieu; Jenkins Mark; Sonenberg Nahum; Lasko Paul F
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.
Genes & development 2005;19(16):1840-3.
2005: Bordeleau Marie-Eve; Matthews James; Wojnar Joanna M; Lindqvist Lisa; Novac Olivia; Jankowsky Eckhard; Sonenberg Nahum; Northcote Peter; Teesdale-Spittle Paul; Pelletier Jerry
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10460-5.
2005: Gorrini Chiara; Loreni Fabrizio; Gandin Valentina; Sala Leonardo A; Sonenberg Nahum; Marchisio Pier Carlo; Biffo Stefano
Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9200-5.
2005: Pyronnet S; Pradayrol L; Sonenberg N
Alternative splicing facilitates internal ribosome entry on the ornithine decarboxylase mRNA.
Cellular and molecular life sciences : CMLS 2005;62(11):1267-74.
2005: Svitkin Yuri V; Pause Arnim; Lopez-Lastra Marcelo; Perreault Sandra; Sonenberg Nahum
Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3.
Journal of virology 2005;79(11):6868-81.
2005: Cho Park F; Poulin Francis; Cho-Park Yoon Andrew; Cho-Park Ian B; Chicoine Jarred D; Lasko Paul; Sonenberg Nahum
A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.
Cell 2005;121(3):411-23.
2005: Holcik Martin; Sonenberg Nahum
Translational control in stress and apoptosis.
Nature reviews. Molecular cell biology 2005;6(4):318-27.
2005: Salaün Patrick; Boulben Sandrine; Mulner-Lorillon Odile; Bellé Robert; Sonenberg Nahum; Morales Julia; Cormier Patrick
Embryonic-stage-dependent changes in the level of eIF4E-binding proteins during early development of sea urchin embryos.
Journal of cell science 2005;118(Pt 7):1385-94.
2005: Ohanna Mickaël; Sobering Andrew K; Lapointe Thomas; Lorenzo Lazaro; Praud Christophe; Petroulakis Emmanuel; Sonenberg Nahum; Kelly Paul A; Sotiropoulos Athanassia; Pende Mario
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.
Nature cell biology 2005;7(3):286-94.
2005: Richter Joel D; Sonenberg Nahum
Regulation of cap-dependent translation by eIF4E inhibitory proteins.
Nature 2005;433(7025):477-80.
2005: Kahvejian Avak; Svitkin Yuri V; Sukarieh Rami; M'Boutchou Marie-Noël; Sonenberg Nahum
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.
Genes & development 2005;19(1):104-13.
2005: Malina Abba; Khan Shakila; Carlson Coby B; Svitkin Yuri; Harvey Isabelle; Sonenberg Nahum; Beal Peter A; Pelletier Jerry
Inhibitory properties of nucleic acid-binding ligands on protein synthesis.
FEBS letters 2005;579(1):79-89.
2005: Mochizuki Kiyotaka; Oguro Akihiro; Ohtsu Takashi; Sonenberg Nahum; Nakamura Yoshikazu
High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation.
RNA (New York, N.Y.) 2005;11(1):77-89.
2004: Deng Jing; Lu Phoebe D; Zhang Yuhong; Scheuner Donalyn; Kaufman Randal J; Sonenberg Nahum; Harding Heather P; Ron David
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.
Molecular and cellular biology 2004;24(23):10161-8.
2004: Baltzis Dionissios; Qu Li-Ke; Papadopoulou Stavroula; Blais Jaime D; Bell John C; Sonenberg Nahum; Koromilas Antonis E
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Journal of virology 2004;78(23):12747-61.
2004: Orton Kevin C; Ling Jun; Waskiewicz Andrew J; Cooper Jonathan A; Merrick William C; Korneeva Nadejda L; Rhoads Robert E; Sonenberg Nahum; Traugh Jolinda A
Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
The Journal of biological chemistry 2004;279(37):38649-57.
2004: Chang Tsung-Cheng; Yamashita Akio; Chen Chyi-Ying A; Yamashita Yukiko; Zhu Wenmiao; Durdan Simon; Kahvejian Avak; Sonenberg Nahum; Shyu Ann-Bin
UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.
Genes & development 2004;18(16):2010-23.
2004: Hay Nissim; Sonenberg Nahum
Upstream and downstream of mTOR.
Genes & development 2004;18(16):1926-45.
2004: Costa-Mattioli Mauro; Svitkin Yuri; Sonenberg Nahum
La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro.
Molecular and cellular biology 2004;24(15):6861-70.
2004: van Breukelen Frank; Sonenberg Nahum; Martin Sandra L
Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(2):R349-53.
2004: Shaffer A L; Shapiro-Shelef Miriam; Iwakoshi Neal N; Lee Ann-Hwee; Qian Shu-Bing; Zhao Hong; Yu Xin; Yang Liming; Tan Bruce K; Rosenwald Andreas; Hurt Elaine M; Petroulakis Emmanuel; Sonenberg Nahum; Yewdell Jonathan W; Calame Kathryn; Glimcher Laurie H; Staudt Louis M
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
Immunity 2004;21(1):81-93.
2004: Avdulov Svetlana; Li Shunan; Michalek Van; Burrichter David; Peterson Mark; Perlman David M; Manivel J Carlos; Sonenberg Nahum; Yee Douglas; Bitterman Peter B; Polunovsky Vitaly A
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.
Cancer cell 2004;5(6):553-63.
2004: Caron Sandrine; Charon Martine; Cramer Elisabeth; Sonenberg Nahum; Dusanter-Fourt Isabelle
Selective modification of eukaryotic initiation factor 4F (eIF4F) at the onset of cell differentiation: recruitment of eIF4GII and long-lasting phosphorylation of eIF4E.
Molecular and cellular biology 2004;24(11):4920-8.
2004: Yang Hsin-Sheng; Cho Myung-Haing; Zakowicz Halina; Hegamyer Glenn; Sonenberg Nahum; Colburn Nancy H
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.
Molecular and cellular biology 2004;24(9):3894-906.
2004: Mamane Yaël; Petroulakis Emmanuel; Rong Liwei; Yoshida Kaori; Ler Lian Wee; Sonenberg Nahum
eIF4E--from translation to transformation.
Oncogene 2004;23(18):3172-9.
2004: Holland Eric C; Sonenberg Nahum; Pandolfi Pier Paolo; Thomas George
Signaling control of mRNA translation in cancer pathogenesis.
Oncogene 2004;23(18):3138-44.
2004: Raught Brian; Peiretti Franck; Gingras Anne-Claude; Livingstone Mark; Shahbazian David; Mayeur Greg L; Polakiewicz Roberto D; Sonenberg Nahum; Hershey John W B
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.
The EMBO journal 2004;23(8):1761-9.
2004: Shibuya Toshiharu; Tange Thomas Ø; Sonenberg Nahum; Moore Melissa J
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay.
Nature structural & molecular biology 2004;11(4):346-51.
2004: Gradi Alessandra; Foeger Nicole; Strong Rebecca; Svitkin Yuri V; Sonenberg Nahum; Skern Tim; Belsham Graham J
Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.
Journal of virology 2004;78(7):3271-8.
2004: Ferraiuolo Maria A; Lee Chung-Sheng; Ler Lian Wee; Hsu Jeanne L; Costa-Mattioli Mauro; Luo Ming-Juan; Reed Robin; Sonenberg Nahum
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4118-23.
2004: Donzé Olivier; Deng Jing; Curran Joseph; Sladek Robert; Picard Didier; Sonenberg Nahum
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs.
The EMBO journal 2004;23(3):564-71.
2004: Roy Guylaine; Miron Mathieu; Khaleghpour Kianoush; Lasko Paul; Sonenberg Nahum
The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth.
Molecular and cellular biology 2004;24(3):1143-54.
2004: Kozlov Guennadi; De Crescenzo Gregory; Lim Nadia S; Siddiqui Nadeem; Fantus Daniel; Kahvejian Avak; Trempe Jean-François; Elias Demetra; Ekiel Irena; Sonenberg Nahum; O'Connor-McCourt Maureen; Gehring Kalle
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase.
The EMBO journal 2004;23(2):272-81.
2004: Svitkin Yuri V; Sonenberg Nahum
An efficient system for cap- and poly(A)-dependent translation in vitro.
Methods in molecular biology (Clifton, N.J.) 2004;257():155-70.
2004: Gingras A C; Raught B; Sonenberg N
mTOR signaling to translation.
Current topics in microbiology and immunology 2004;279():169-97.
2003: Miron Mathieu; Lasko Paul; Sonenberg Nahum
Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.
Molecular and cellular biology 2003;23(24):9117-26.
2003: Poulin Francis; Brueschke Andrea; Sonenberg Nahum
Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.
The Journal of biological chemistry 2003;278(52):52290-7.
2003: Qin Hui; Raught Brian; Sonenberg Nahum; Goldstein Elaine G; Edelman Arthur M
Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.
The Journal of biological chemistry 2003;278(49):48570-9.
2003: Lekmine Fatima; Uddin Shahab; Sassano Antonella; Parmar Simrit; Brachmann Saskia M; Majchrzak Beata; Sonenberg Nahum; Hay Nissim; Fish Eleanor N; Platanias Leonidas C
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.
The Journal of biological chemistry 2003;278(30):27772-80.
2003: Svitkin Yuri V; Sonenberg Nahum
Cell-free synthesis of encephalomyocarditis virus.
Journal of virology 2003;77(11):6551-5.
2003: Gradi Alessandra; Svitkin Yuri V; Sommergruber Wolfgang; Imataka Hiroaki; Morino Shigenobu; Skern Tim; Sonenberg Nahum
Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.
Journal of virology 2003;77(8):5026-9.
2003: Oguro Akihiro; Ohtsu Takashi; Svitkin Yuri V; Sonenberg Nahum; Nakamura Yoshikazu
RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis.
RNA (New York, N.Y.) 2003;9(4):394-407.
2003: Brasey Ann; Lopez-Lastra Marcelo; Ohlmann Theophile; Beerens Nancy; Berkhout Ben; Darlix Jean-Luc; Sonenberg Nahum
The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle.
Journal of virology 2003;77(7):3939-49.
2003: Salaün Patrick; Pyronnet Stéphane; Morales Julia; Mulner-Lorillon Odile; Bellé Robert; Sonenberg Nahum; Cormier Patrick
eIF4E/4E-BP dissociation and 4E-BP degradation in the first mitotic division of the sea urchin embryo.
Developmental biology 2003;255(2):428-39.
2003: Shi Yuguang; Taylor Simeon I; Tan Seng-Lai; Sonenberg Nahum
When translation meets metabolism: multiple links to diabetes.
Endocrine reviews 2003;24(1):91-101.
2003: Sonenberg Nahum; Dever Thomas E
Eukaryotic translation initiation factors and regulators.
Current opinion in structural biology 2003;13(1):56-63.
2003: Zuberek Joanna; Wyslouch-Cieszynska Aleksandra; Niedzwiecka Anna; Dadlez Michal; Stepinski Janusz; Augustyniak Wojciech; Gingras Anne-Claude; Zhang Zhibo; Burley Stephen K; Sonenberg Nahum; Stolarski Ryszard; Darzynkiewicz Edward
Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein.
RNA (New York, N.Y.) 2003;9(1):52-61.
2003: Yang Hsin-Sheng; Jansen Aaron P; Komar Anton A; Zheng Xiaojing; Merrick William C; Costes Sylvain; Lockett Stephen J; Sonenberg Nahum; Colburn Nancy H
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.
Molecular and cellular biology 2003;23(1):26-37.
2003: Cormier Patrick; Pyronnet Stéphane; Salaün Patrick; Mulner-Lorillon Odile; Sonenberg Nahum
Cap-dependent translation and control of the cell cycle.
Progress in cell cycle research 2003;5():469-75.
2002: Wang Huidong; Iacoangeli Anna; Popp Susanna; Muslimov Ilham A; Imataka Hiroaki; Sonenberg Nahum; Lomakin Ivan B; Tiedge Henri
Dendritic BC1 RNA: functional role in regulation of translation initiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(23):10232-41.
2002: Senthil Duraisamy; Choudhury Goutam Ghosh; Abboud Hanna E; Sonenberg Nahum; Kasinath Balakuntalam S
Regulation of protein synthesis by IGF-I in proximal tubular epithelial cells.
American journal of physiology. Renal physiology 2002;283(6):F1226-36.
2002: Uchida Naoyuki; Hoshino Shin-Ichi; Imataka Hiroaki; Sonenberg Nahum; Katada Toshiaki
A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation.
The Journal of biological chemistry 2002;277(52):50286-92.
2002: Tan Seng-Lai; Pause Arnim; Shi Yuguang; Sonenberg Nahum
Hepatitis C therapeutics: current status and emerging strategies.
Nature reviews. Drug discovery 2002;1(11):867-81.
2002: Koumenis Constantinos; Naczki Christine; Koritzinsky Marianne; Rastani Sally; Diehl Alan; Sonenberg Nahum; Koromilas Antonis; Wouters Bradly G
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.
Molecular and cellular biology 2002;22(21):7405-16.
2002: Niedzwiecka Anna; Stepinski Janusz; Darzynkiewicz Edward; Sonenberg Nahum; Stolarski Ryszard
Positive heat capacity change upon specific binding of translation initiation factor eIF4E to mRNA 5' cap.
Biochemistry 2002;41(40):12140-8.
2002: Deng Jing; Harding Heather P; Raught Brian; Gingras Anne-Claude; Berlanga Juan Jose; Scheuner Donalyn; Kaufman Randal J; Ron David; Sonenberg Nahum
Activation of GCN2 in UV-irradiated cells inhibits translation.
Current biology : CB 2002;12(15):1279-86.
2002: West Neva; Roy-Engel Astrid M; Imataka Hiroaki; Sonenberg Nahum; Deininger Prescott
Shared protein components of SINE RNPs.
Journal of molecular biology 2002;321(3):423-32.
2002: Nikolcheva Tania; Pyronnet Stephane; Chou Szu-yi; Sonenberg Nahum; Song An; Clayberger Carol; Krensky Alan M
A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.
The Journal of clinical investigation 2002;110(1):119-26.
2002: Niedzwiecka Anna; Marcotrigiano Joseph; Stepinski Janusz; Jankowska-Anyszka Marzena; Wyslouch-Cieszynska Aleksandra; Dadlez Michal; Gingras Anne-Claude; Mak Pawel; Darzynkiewicz Edward; Sonenberg Nahum; Burley Stephen K; Stolarski Ryszard
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
Journal of molecular biology 2002;319(3):615-35.
2002: Roy Guylaine; De Crescenzo Gregory; Khaleghpour Kianoush; Kahvejian Avak; O'Connor-McCourt Maureen; Sonenberg Nahum
Paip1 interacts with poly(A) binding protein through two independent binding motifs.
Molecular and cellular biology 2002;22(11):3769-82.
2002: Li Shunan; Sonenberg Nahum; Gingras Anne-Claude; Peterson Mark; Avdulov Svetlana; Polunovsky Vitaly A; Bitterman Peter B
Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.
Molecular and cellular biology 2002;22(8):2853-61.
2002: Lachance Pascal E D; Miron Mathieu; Raught Brian; Sonenberg Nahum; Lasko Paul
Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth.
Molecular and cellular biology 2002;22(6):1656-63.
2002: Maeshima Yohei; Sudhakar Akulapalli; Lively Julie C; Ueki Kohjiro; Kharbanda Surender; Kahn C Ronald; Sonenberg Nahum; Hynes Richard O; Kalluri Raghu
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.
Science (New York, N.Y.) 2002;295(5552):140-3.
2002: Tang Shao Jun; Reis Gerald; Kang Hyejin; Gingras Anne-Claude; Sonenberg Nahum; Schuman Erin M
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):467-72.
2001: Svitkin Y V; Imataka H; Khaleghpour K; Kahvejian A; Liebig H D; Sonenberg N
Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.
RNA (New York, N.Y.) 2001;7(12):1743-52.
2001: Miron M; Sonenberg N
Regulation of translation via TOR signaling: insights from Drosophila melanogaster.
The Journal of nutrition 2001;131(11):2988S-93S.
2001: Gingras A C; Raught B; Gygi S P; Niedzwiecka A; Miron M; Burley S K; Polakiewicz R D; Wyslouch-Cieszynska A; Aebersold R; Sonenberg N
Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
Genes & development 2001;15(21):2852-64.
2001: Tsukiyama-Kohara K; Poulin F; Kohara M; DeMaria C T; Cheng A; Wu Z; Gingras A C; Katsume A; Elchebly M; Spiegelman B M; Harper M E; Tremblay M L; Sonenberg N
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Nature medicine 2001;7(10):1128-32.
2001: Evdokimova V; Ruzanov P; Imataka H; Raught B; Svitkin Y; Ovchinnikov L P; Sonenberg N
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer.
The EMBO journal 2001;20(19):5491-502.
2001: Pyronnet S; Dostie J; Sonenberg N
Suppression of cap-dependent translation in mitosis.
Genes & development 2001;15(16):2083-93.
2001: Khaleghpour K; Kahvejian A; De Crescenzo G; Roy G; Svitkin Y V; Imataka H; O'Connor-McCourt M; Sonenberg N
Dual interactions of the translational repressor Paip2 with poly(A) binding protein.
Molecular and cellular biology 2001;21(15):5200-13.
2001: Raught B; Gingras A C; Sonenberg N
The target of rapamycin (TOR) proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7037-44.
2001: Miron M; Verdú J; Lachance P E; Birnbaum M J; Lasko P F; Sonenberg N
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila.
Nature cell biology 2001;3(6):596-601.
2001: Cormier P; Pyronnet S; Morales J; Mulner-Lorillon O; Sonenberg N; Bellé R
eIF4E association with 4E-BP decreases rapidly following fertilization in sea urchin.
Developmental biology 2001;232(2):275-83.
2001: Gingras A C; Raught B; Sonenberg N
Regulation of translation initiation by FRAP/mTOR.
Genes & development 2001;15(7):807-26.
2001: Deo R C; Sonenberg N; Burley S K
X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4414-9.
2001: Svitkin Y V; Pause A; Haghighat A; Pyronnet S; Witherell G; Belsham G J; Sonenberg N
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.
RNA (New York, N.Y.) 2001;7(3):382-94.
2001: Bhandari B K; Feliers D; Duraisamy S; Stewart J L; Gingras A C; Abboud H E; Choudhury G G; Sonenberg N; Kasinath B S
Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells.
Kidney international 2001;59(3):866-75.
2001: Pyronnet S; Sonenberg N
Cell-cycle-dependent translational control.
Current opinion in genetics & development 2001;11(1):13-8.
2001: Khaleghpour K; Svitkin Y V; Craig A W; DeMaria C T; Deo R C; Burley S K; Sonenberg N
Translational repression by a novel partner of human poly(A) binding protein, Paip2.
Molecular cell 2001;7(1):205-16.
2001: Marcotrigiano J; Lomakin I B; Sonenberg N; Pestova T V; Hellen C U; Burley S K
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery.
Molecular cell 2001;7(1):193-203.
2001: Kahvejian A; Roy G; Sonenberg N
The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation.
Cold Spring Harbor symposia on quantitative biology 2001;66():293-300.
2001: Gingras A C; Raught B; Sonenberg N
Control of translation by the target of rapamycin proteins.
Progress in molecular and subcellular biology 2001;27():143-74.
2000: Grosset C; Chen C Y; Xu N; Sonenberg N; Jacquemin-Sablon H; Shyu A B
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.
Cell 2000;103(1):29-40.
2000: Wakiyama M; Imataka H; Sonenberg N
Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation.
Current biology : CB 2000;10(18):1147-50.
2000: Polunovsky V A; Gingras A C; Sonenberg N; Peterson M; Tan A; Rubins J B; Manivel J C; Bitterman P B
Translational control of the antiapoptotic function of Ras.
The Journal of biological chemistry 2000;275(32):24776-80.
2000: Cosentino G P; Schmelzle T; Haghighat A; Helliwell S B; Hall M N; Sonenberg N
Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.
Molecular and cellular biology 2000;20(13):4604-13.
2000: Gregorieff A; Pyronnet S; Sonenberg N; Veillette A
Regulation of SOCS-1 expression by translational repression.
The Journal of biological chemistry 2000;275(28):21596-604.
2000: Dostie J; Ferraiuolo M; Pause A; Adam S A; Sonenberg N
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.
The EMBO journal 2000;19(12):3142-56.
2000: Pyronnet S; Pradayrol L; Sonenberg N
A cell cycle-dependent internal ribosome entry site.
Molecular cell 2000;5(4):607-16.
2000: Tan A; Bitterman P; Sonenberg N; Peterson M; Polunovsky V
Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.
Oncogene 2000;19(11):1437-47.
2000: Raught B; Gingras A C; Gygi S P; Imataka H; Morino S; Gradi A; Aebersold R; Sonenberg N
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.
The EMBO journal 2000;19(3):434-44.
2000: Dostie J; Lejbkowicz F; Sonenberg N
Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles.
The Journal of cell biology 2000;148(2):239-47.
2000: Morino S; Imataka H; Svitkin Y V; Pestova T V; Sonenberg N
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region.
Molecular and cellular biology 2000;20(2):468-77.
1999: Li Q; Imataka H; Morino S; Rogers G W; Richter-Cook N J; Merrick W C; Sonenberg N
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII.
Molecular and cellular biology 1999;19(11):7336-46.
1999: Deo R C; Bonanno J B; Sonenberg N; Burley S K
Recognition of polyadenylate RNA by the poly(A)-binding protein.
Cell 1999;98(6):835-45.
1999: Marcotrigiano J; Gingras A C; Sonenberg N; Burley S K
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Molecular cell 1999;3(6):707-16.
1999: Gingras A C; Gygi S P; Raught B; Polakiewicz R D; Abraham R T; Hoekstra M F; Aebersold R; Sonenberg N
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Genes & development 1999;13(11):1422-37.
1999: Khaleghpour K; Pyronnet S; Gingras A C; Sonenberg N
Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.
Molecular and cellular biology 1999;19(6):4302-10.
1999: Donzé O; Dostie J; Sonenberg N
Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression.
Virology 1999;256(2):322-9.
1999: Svitkin Y V; Gradi A; Imataka H; Morino S; Sonenberg N
Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection.
Journal of virology 1999;73(4):3467-72.
1999: Pyronnet S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
The EMBO journal 1999;18(1):270-9.
1999: Gingras A C; Raught B; Sonenberg N
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Annual review of biochemistry 1999;68():913-63.
1998: Imataka H; Gradi A; Sonenberg N
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.
The EMBO journal 1998;17(24):7480-9.
1998: Gradi A; Svitkin Y V; Imataka H; Sonenberg N
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11089-94.
1998: Svitkin Y V; Hahn H; Gingras A C; Palmenberg A C; Sonenberg N
Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus.
Journal of virology 1998;72(7):5811-9.
1998: Poulin F; Gingras A C; Olsen H; Chevalier S; Sonenberg N
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family.
The Journal of biological chemistry 1998;273(22):14002-7.
1998: Rom E; Kim H C; Gingras A C; Marcotrigiano J; Favre D; Olsen H; Burley S K; Sonenberg N
Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein.
The Journal of biological chemistry 1998;273(21):13104-9.
1998: Pyronnet S; Gingras A C; Bouisson M; Kowalski-Chauvel A; Seva C; Vaysse N; Sonenberg N; Pradayrol L
Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA.
Oncogene 1998;16(17):2219-27.
1998: Sonenberg N; Gingras A C
The mRNA 5' cap-binding protein eIF4E and control of cell growth.
Current opinion in cell biology 1998;10(2):268-75.
1998: Craig A W; Haghighat A; Yu A T; Sonenberg N
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
Nature 1998;392(6675):520-3.
1998: Gingras A C; Kennedy S G; O'Leary M A; Sonenberg N; Hay N
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.
Genes & development 1998;12(4):502-13.
1998: Gradi A; Imataka H; Svitkin Y V; Rom E; Raught B; Morino S; Sonenberg N
A novel functional human eukaryotic translation initiation factor 4G.
Molecular and cellular biology 1998;18(1):334-42.
1997: Imataka H; Sonenberg N
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.
Molecular and cellular biology 1997;17(12):6940-7.
1997: Gingras A C; Sonenberg N
Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2.
Virology 1997;237(1):182-6.
1997: Haghighat A; Sonenberg N
eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure.
The Journal of biological chemistry 1997;272(35):21677-80.
1997: Marcotrigiano J; Gingras A C; Sonenberg N; Burley S K
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.
Cell 1997;89(6):951-61.
1997: Imataka H; Olsen H S; Sonenberg N
A new translational regulator with homology to eukaryotic translation initiation factor 4G.
The EMBO journal 1997;16(4):817-25.
1997: Fleurent M; Gingras A C; Sonenberg N; Meloche S
Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism.
The Journal of biological chemistry 1997;272(7):4006-12.
1997: Nagai K; Wong A H; Li S; Tam W N; Cuddihy A R; Sonenberg N; Mathews M B; Hiscott J; Wainberg M A; Koromilas A E
Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR.
Journal of virology 1997;71(2):1718-25.
1997: Méthot N; Rom E; Olsen H; Sonenberg N
The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.
The Journal of biological chemistry 1997;272(2):1110-6.
1997: Craig A W; Svitkin Y V; Lee H S; Belsham G J; Sonenberg N
The La autoantigen contains a dimerization domain that is essential for enhancing translation.
Molecular and cellular biology 1997;17(1):163-9.
1997: Marcotrigiano J; Gingras A C; Sonenberg N; Burley S K
X-ray studies of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.
Nucleic acids symposium series 1997;(36):8-11.
1996: Svitkin Y V; Ovchinnikov L P; Dreyfuss G; Sonenberg N
General RNA binding proteins render translation cap dependent.
The EMBO journal 1996;15(24):7147-55.
1996: Tsukiyama-Kohara K; Vidal S M; Gingras A C; Glover T W; Hanash S M; Heng H; Sonenberg N
Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2.
Genomics 1996;38(3):353-63.
1996: Beretta L; Svitkin Y V; Sonenberg N
Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection.
Journal of virology 1996;70(12):8993-6.
1996: Haghighat A; Svitkin Y; Novoa I; Kuechler E; Skern T; Sonenberg N
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase.
Journal of virology 1996;70(12):8444-50.
1996: Rousseau D; Gingras A C; Pause A; Sonenberg N
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.
Oncogene 1996;13(11):2415-20.
1996: Méthot N; Song M S; Sonenberg N
A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.
Molecular and cellular biology 1996;16(10):5328-34.
1996: Raught B; Gingras A C; James A; Medina D; Sonenberg N; Rosen J M
Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells.
Cancer research 1996;56(19):4382-6.
1996: Craig A W; Cosentino G P; Donzé O; Sonenberg N
The kinase insert domain of interferon-induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L.
The Journal of biological chemistry 1996;271(40):24526-33.
1996: Beauparlant P; Kwon H; Clarke M; Lin R; Sonenberg N; Wainberg M; Hiscott J
Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication.
Journal of virology 1996;70(9):5777-85.
1996: Lavoie C A; Lachance P E; Sonenberg N; Lasko P
Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins.
The Journal of biological chemistry 1996;271(27):16393-8.
1996: Whalen S G; Gingras A C; Amankwa L; Mader S; Branton P E; Aebersold R; Sonenberg N
Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.
The Journal of biological chemistry 1996;271(20):11831-7.
1996: Gingras A C; Svitkin Y; Belsham G J; Pause A; Sonenberg N
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5578-83.
1996: Beretta L; Gabbay M; Berger R; Hanash S M; Sonenberg N
Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias.
Oncogene 1996;12(7):1593-6.
1996: Beretta L; Gingras A C; Svitkin Y V; Hall M N; Sonenberg N
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
The EMBO journal 1996;15(3):658-64.
1996: Rousseau D; Kaspar R; Rosenwald I; Gehrke L; Sonenberg N
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1065-70.
1996: Methot N; Pickett G; Keene J D; Sonenberg N
In vitro RNA selection identifies RNA ligands that specifically bind to eukaryotic translation initiation factor 4B: the role of the RNA remotif.
RNA (New York, N.Y.) 1996;2(1):38-50.
1995: Haghighat A; Mader S; Pause A; Sonenberg N
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
The EMBO journal 1995;14(22):5701-9.
1995: Koromilas A E; Cantin C; Craig A W; Jagus R; Hiscott J; Sonenberg N
The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.
The Journal of biological chemistry 1995;270(43):25426-34.
1995: Cosentino G P; Venkatesan S; Serluca F C; Green S R; Mathews M B; Sonenberg N
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9445-9.
1995: Rosenwald I B; Kaspar R; Rousseau D; Gehrke L; Leboulch P; Chen J J; Schmidt E V; Sonenberg N; London I M
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels.
The Journal of biological chemistry 1995;270(36):21176-80.
1995: Mader S; Lee H; Pause A; Sonenberg N
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.
Molecular and cellular biology 1995;15(9):4990-7.
1995: Donzé O; Jagus R; Koromilas A E; Hershey J W; Sonenberg N
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.
The EMBO journal 1995;14(15):3828-34.
1995: Altmann M; Wittmer B; Méthot N; Sonenberg N; Trachsel H
The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity.
The EMBO journal 1995;14(15):3820-7.
1995: Kirchhoff S; Koromilas A E; Schaper F; Grashoff M; Sonenberg N; Hauser H
IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.
Oncogene 1995;11(3):439-45.
1995: Masison D C; Blanc A; Ribas J C; Carroll K; Sonenberg N; Wickner R B
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system.
Molecular and cellular biology 1995;15(5):2763-71.
1995: Mader S; Sonenberg N
Cap binding complexes and cellular growth control.
Biochimie 1995;77(1-2):40-4.
1995: Belsham G J; Sonenberg N; Svitkin Y V
The role of the La autoantigen in internal initiation.
Current topics in microbiology and immunology 1995;203():85-98.
1994: Beauparlant P; Kwan I; Bitar R; Chou P; Koromilas A E; Sonenberg N; Hiscott J
Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation.
Oncogene 1994;9(11):3189-97.
1994: Svitkin Y V; Pause A; Sonenberg N
La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.
Journal of virology 1994;68(11):7001-7.
1994: Lin T A; Kong X; Haystead T A; Pause A; Belsham G; Sonenberg N; Lawrence J C
PHAS-I as a link between mitogen-activated protein kinase and translation initiation.
Science (New York, N.Y.) 1994;266(5185):653-6.
1994: Pause A; Belsham G J; Gingras A C; Donzé O; Lin T A; Lawrence J C; Sonenberg N
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
Nature 1994;371(6500):762-7.
1994: Lavoie C; Tam R; Clark M; Lee H; Sonenberg N; Lasko P
Suppression of a temperature-sensitive cdc33 mutation of yeast by a multicopy plasmid expressing a Drosophila ribosomal protein.
The Journal of biological chemistry 1994;269(20):14625-30.
1994: Blanc A; Ribas J C; Wickner R B; Sonenberg N
His-154 is involved in the linkage of the Saccharomyces cerevisiae L-A double-stranded RNA virus Gag protein to the cap structure of mRNAs and is essential for M1 satellite virus expression.
Molecular and cellular biology 1994;14(4):2664-74.
1994: Méthot N; Pause A; Hershey J W; Sonenberg N
The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.
Molecular and cellular biology 1994;14(4):2307-16.
1994: Pause A; Méthot N; Svitkin Y; Merrick W C; Sonenberg N
Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.
The EMBO journal 1994;13(5):1205-15.
1994: Svitkin Y V; Meerovitch K; Lee H S; Dholakia J N; Kenan D J; Agol V I; Sonenberg N
Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro.
Journal of virology 1994;68(3):1544-50.
1994: Sonenberg N
Regulation of translation and cell growth by eIF-4E.
Biochimie 1994;76(9):839-46.
1993: Rosenwald I B; Lazaris-Karatzas A; Sonenberg N; Schmidt E V
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.
Molecular and cellular biology 1993;13(12):7358-63.
1993: Sonenberg N
Translation factors as effectors of cell growth and tumorigenesis.
Current opinion in cell biology 1993;5(6):955-60.
1993: Pause A; Méthot N; Sonenberg N
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.
Molecular and cellular biology 1993;13(11):6789-98.
1993: Goyer C; Altmann M; Lee H S; Blanc A; Deshmukh M; Woolford J L; Trachsel H; Sonenberg N
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.
Molecular and cellular biology 1993;13(8):4860-74.
1993: Meerovitch K; Svitkin Y V; Lee H S; Lejbkowicz F; Kenan D J; Chan E K; Agol V I; Keene J D; Sonenberg N
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Journal of virology 1993;67(7):3798-807.
1993: Yoder-Hill J; Pause A; Sonenberg N; Merrick W C
The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.
The Journal of biological chemistry 1993;268(8):5566-73.
1993: Barnett R W; Delling U; Kuperman R; Sonenberg N; Sumner-Smith M
Rotational symmetry in ribonucleotide strand requirements for binding of HIV-1 Tat protein to TAR RNA.
Nucleic acids research 1993;21(1):151-4.
1993: Svitkin Y V; Alpatova G A; Lipskaya G A; Maslova S V; Agol V I; Kew O; Meerovitch K; Sonenberg N
Towards development of an in vitro translation test for poliovirus neurovirulence.
Developments in biological standardization 1993;78():27-32.
1993: Sonenberg N
Remarks on the mechanism of ribosome binding to eukaryotic mRNAs.
Gene expression 1993;3(3):317-23.
1992: Koromilas A E; Lazaris-Karatzas A; Sonenberg N
mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.
The EMBO journal 1992;11(11):4153-8.
1992: Lanker S; Müller P P; Altmann M; Goyer C; Sonenberg N; Trachsel H
Interactions of the eIF-4F subunits in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1992;267(29):21167-71.
1992: Goyer C; Lee H S; Malo D; Sonenberg N
Isolation of a yeast gene encoding a protein homologous to the human Tat-binding protein TBP-1.
DNA and cell biology 1992;11(8):579-85.
1992: Lejbkowicz F; Goyer C; Darveau A; Neron S; Lemieux R; Sonenberg N
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9612-6.
1992: Lazaris-Karatzas A; Smith M R; Frederickson R M; Jaramillo M L; Liu Y L; Kung H F; Sonenberg N
Ras mediates translation initiation factor 4E-induced malignant transformation.
Genes & development 1992;6(9):1631-42.
1992: Koromilas A E; Roy S; Barber G N; Katze M G; Sonenberg N
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.
Science (New York, N.Y.) 1992;257(5077):1685-9.
1992: Blanc A; Goyer C; Sonenberg N
The coat protein of the yeast double-stranded RNA virus L-A attaches covalently to the cap structure of eukaryotic mRNA.
Molecular and cellular biology 1992;12(8):3390-8.
1992: Blum S; Schmid S R; Pause A; Buser P; Linder P; Sonenberg N; Trachsel H
ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7664-8.
1992: Pause A; Sonenberg N
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.
The EMBO journal 1992;11(7):2643-54.
1992: Delling U; Reid L S; Barnett R W; Ma M Y; Climie S; Sumner-Smith M; Sonenberg N
Conserved nucleotides in the TAR RNA stem of human immunodeficiency virus type 1 are critical for Tat binding and trans activation: model for TAR RNA tertiary structure.
Journal of virology 1992;66(5):3018-25.
1992: Frederickson R M; Sonenberg N
Signal transduction and regulation of translation initiation.
Seminars in cell biology 1992;3(2):107-15.
1992: Frederickson R M; Mushynski W E; Sonenberg N
Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.
Molecular and cellular biology 1992;12(3):1239-47.
1992: Lazaris-Karatzas A; Sonenberg N
The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.
Molecular and cellular biology 1992;12(3):1234-8.
1991: Jaramillo M; Dever T E; Merrick W C; Sonenberg N
RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B.
Molecular and cellular biology 1991;11(12):5992-7.
1991: Meerovitch K; Nicholson R; Sonenberg N
In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region.
Journal of virology 1991;65(11):5895-901.
1991: Nicholson R; Pelletier J; Le S Y; Sonenberg N
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies.
Journal of virology 1991;65(11):5886-94.
1991: Sumner-Smith M; Roy S; Barnett R; Reid L S; Kuperman R; Delling U; Sonenberg N
Critical chemical features in trans-acting-responsive RNA are required for interaction with human immunodeficiency virus type 1 Tat protein.
Journal of virology 1991;65(10):5196-202.
1991: Fagan R J; Lazaris-Karatzas A; Sonenberg N; Rozen R
Translational control of ornithine aminotransferase. Modulation by initiation factor eIF-4E.
The Journal of biological chemistry 1991;266(25):16518-23.
1991: Delling U; Roy S; Sumner-Smith M; Barnett R; Reid L; Rosen C A; Sonenberg N
The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6234-8.
1991: Jaramillo M; Pelletier J; Edery I; Nielsen P J; Sonenberg N
Multiple mRNAs encode the murine translation initiation factor eIF-4E.
The Journal of biological chemistry 1991;266(16):10446-51.
1991: Smith M R; Jaramillo M; Tuazon P T; Traugh J A; Liu Y L; Sonenberg N; Kung H F
Modulation of the mitogenic activity of eukaryotic translation initiation factor-4E by protein kinase C.
The New biologist 1991;3(6):601-7.
1991: Frederickson R M; Montine K S; Sonenberg N
Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines.
Molecular and cellular biology 1991;11(5):2896-900.
1991: Sonenberg N
Picornavirus RNA translation continues to surprise.
Trends in genetics : TIG 1991;7(4):105-6.
1991: Dorfman J; Lazaris-Karatzas A; Malo D; Sonenberg N; Gros P
Chromosomal assignment of one of the mammalian translation initiation factor eIF-4E genes.
Genomics 1991;9(4):785-8.
1991: Roy S; Agy M; Hovanessian A G; Sonenberg N; Katze M G
The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase.
Journal of virology 1991;65(2):632-40.
1990: Roy S; Delling U; Chen C H; Rosen C A; Sonenberg N
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.
Genes & development 1990;4(8):1365-73.
1990: Altmann M; Blum S; Pelletier J; Sonenberg N; Wilson T M; Trachsel H
Translation initiation factor-dependent extracts from Saccharomyces cerevisiae.
Biochimica et biophysica acta 1990;1050(1-3):155-9.
1990: Jaramillo M; Browning K; Dever T E; Blum S; Trachsel H; Merrick W C; Ravel J M; Sonenberg N
Translation initiation factors that function as RNA helicases from mammals, plants and yeast.
Biochimica et biophysica acta 1990;1050(1-3):134-9.
1990: Smith M R; Jaramillo M; Liu Y L; Dever T E; Merrick W C; Kung H F; Sonenberg N
Translation initiation factors induce DNA synthesis and transform NIH 3T3 cells.
The New biologist 1990;2(7):648-54.
1990: Lazaris-Karatzas A; Montine K S; Sonenberg N
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap.
Nature 1990;345(6275):544-7.
1990: Sonenberg N
Measures and countermeasures in the modulation of initiation factor activities by viruses.
The New biologist 1990;2(5):402-9.
1990: Roy S; Parkin N T; Rosen C; Itovitch J; Sonenberg N
Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.
Journal of virology 1990;64(3):1402-6.
1990: Rozen F; Edery I; Meerovitch K; Dever T E; Merrick W C; Sonenberg N
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
Molecular and cellular biology 1990;10(3):1134-44.
1990: Roy S; Katze M G; Parkin N T; Edery I; Hovanessian A G; Sonenberg N
Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product.
Science (New York, N.Y.) 1990;247(4947):1216-9.
1990: Sonenberg N
Poliovirus translation.
Current topics in microbiology and immunology 1990;161():23-47.
1990: Sonenberg N; Meerovitch K
Translation of poliovirus mRNA.
Enzyme 1990;44(1-4):278-91.
1989: Altmann M; Sonenberg N; Trachsel H
Translation in Saccharomyces cerevisiae: initiation factor 4E-dependent cell-free system.
Molecular and cellular biology 1989;9(10):4467-72.
1989: Rozen F; Pelletier J; Trachsel H; Sonenberg N
A lysine substitution in the ATP-binding site of eucaryotic initiation factor 4A abrogates nucleotide-binding activity.
Molecular and cellular biology 1989;9(9):4061-3.
1989: Altmann M; Müller P P; Pelletier J; Sonenberg N; Trachsel H
A mammalian translation initiation factor can substitute for its yeast homologue in vivo.
The Journal of biological chemistry 1989;264(21):12145-7.
1989: Meerovitch K; Pelletier J; Sonenberg N
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation.
Genes & development 1989;3(7):1026-34.
1989: Parkin N T; Sonenberg N
Identification of a protein that binds specifically to RNA from the first exon of c-myc.
Oncogene 1989;4(7):815-22.
1989: Goyer C; Altmann M; Trachsel H; Sonenberg N
Identification and characterization of cap-binding proteins from yeast.
The Journal of biological chemistry 1989;264(13):7603-10.
1989: McCubbin W D; Edery I; Altmann M; Sonenberg N; Kay C M
Circular dichroism and fluorescence studies on five mutant forms of protein synthesis initiation factor eIF-4E, from the yeast Saccharomyces cerevisiae.
FEBS letters 1989;245(1-2):261-6.
1989: Edery I; Petryshyn R; Sonenberg N
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism.
Cell 1989;56(2):303-12.
1989: Pelletier J; Sonenberg N
Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts.
Journal of virology 1989;63(1):441-4.
1988: Edery I; Altmann M; Sonenberg N
High-level synthesis in Escherichia coli of functional cap-binding eukaryotic initiation factor eIF-4E and affinity purification using a simplified cap-analog resin.
Gene 1988;74(2):517-25.
1988: Pelletier J; Flynn M E; Kaplan G; Racaniello V; Sonenberg N
Mutational analysis of upstream AUG codons of poliovirus RNA.
Journal of virology 1988;62(12):4486-92.
1988: Lazarus P; Parkin N; Sonenberg N
Developmental regulation of translation by the 5' noncoding region of murine c-myc mRNA in Xenopus laevis.
Oncogene 1988;3(5):517-21.
1988: McCubbin W D; Edery I; Altmann M; Sonenberg N; Kay C M
Circular dichroism and fluorescence studies on protein synthesis initiation factor eIF-4E and two mutant forms from the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1988;263(33):17663-71.
1988: Altmann M; Edery I; Trachsel H; Sonenberg N
Site-directed mutagenesis of the tryptophan residues in yeast eukaryotic initiation factor 4E. Effects on cap binding activity.
The Journal of biological chemistry 1988;263(33):17229-32.
1988: Parkin N T; Cohen E A; Darveau A; Rosen C; Haseltine W; Sonenberg N
Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation.
The EMBO journal 1988;7(9):2831-7.
1988: Parkin N; Darveau A; Nicholson R; Sonenberg N
cis-acting translational effects of the 5' noncoding region of c-myc mRNA.
Molecular and cellular biology 1988;8(7):2875-83.
1988: Pelletier J; Sonenberg N
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA.
Nature 1988;334(6180):320-5.
1988: Pelletier J; Kaplan G; Racaniello V R; Sonenberg N
Translational efficiency of poliovirus mRNA: mapping inhibitory cis-acting elements within the 5' noncoding region.
Journal of virology 1988;62(7):2219-27.
1988: Pelletier J; Kaplan G; Racaniello V R; Sonenberg N
Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region.
Molecular and cellular biology 1988;8(3):1103-12.
1987: Pelletier J; Sonenberg N
The involvement of mRNA secondary structure in protein synthesis.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1987;65(6):576-81.
1985: Altmann M; Edery I; Sonenberg N; Trachsel H
Purification and characterization of protein synthesis initiation factor eIF-4E from the yeast Saccharomyces cerevisiae.
Biochemistry 1985;24(22):6085-9.
1984: Etchison D; Hansen J; Ehrenfeld E; Edery I; Sonenberg N; Milburn S; Hershey J W
Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells.
Journal of virology 1984;51(3):832-7.
1983: Edery I; Hümbelin M; Darveau A; Lee K A; Milburn S; Hershey J W; Trachsel H; Sonenberg N
Involvement of eukaryotic initiation factor 4A in the cap recognition process.
The Journal of biological chemistry 1983;258(18):11398-403.
1983: Lee K A; Guertin D; Sonenberg N
mRNA secondary structure as a determinant in cap recognition and initiation complex formation. ATP-Mg2+ independent cross-linking of cap binding proteins to m7I-capped inosine-substituted reovirus mRNA.
The Journal of biological chemistry 1983;258(2):707-10.
1982: Sonenberg N; Guertin D; Lee K A
Capped mRNAs with reduced secondary structure can function in extracts from poliovirus-infected cells.
Molecular and cellular biology 1982;2(12):1633-8.
1982: Etchison D; Milburn S C; Edery I; Sonenberg N; Hershey J W
Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.
The Journal of biological chemistry 1982;257(24):14806-10.
1981: Sonenberg N; Guertin D; Cleveland D; Trachsel H
Probing the function of the eucaryotic 5' cap structure by using a monoclonal antibody directed against cap-binding proteins.
Cell 1981;27(3 Pt 2):563-72.

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