Dale Boger

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MacMillan Karen S; Lajiness James P; Cara Carlota Lopez; Romagnoli Romeo; Robertson William M; Hwang Inkyu; Baraldi Pier Giovanni; Boger Dale L
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Garfunkle Joie; Kimball F Scott; Trzupek John D; Takizawa Shinobu; Shimamura Hiroyuki; Tomishima Masaki; Boger Dale L
Total synthesis of chloropeptin II (complestatin) and chloropeptin I.
Shi Jin; Stover James S; Whitby Landon R; Vogt Peter K; Boger Dale L
Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.

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All Publications

2009: MacMillan Karen S; Lajiness James P; Cara Carlota Lopez; Romagnoli Romeo; Robertson William M; Hwang Inkyu; Baraldi Pier Giovanni; Boger Dale L
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Bioorganic & medicinal chemistry letters 2009;19(24):6962-5.
2009: Garfunkle Joie; Kimball F Scott; Trzupek John D; Takizawa Shinobu; Shimamura Hiroyuki; Tomishima Masaki; Boger Dale L
Total synthesis of chloropeptin II (complestatin) and chloropeptin I.
Journal of the American Chemical Society 2009;131(44):16036-8.
2009: Shi Jin; Stover James S; Whitby Landon R; Vogt Peter K; Boger Dale L
Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.
Bioorganic & medicinal chemistry letters 2009;19(21):6038-41.
2009: Fang Xiao; Nam Joonwoo; Shin Dongwoo; Rew Yosup; Boger Dale L; Walker Suzanne
Functional and biochemical analysis of a key series of ramoplanin analogues.
Bioorganic & medicinal chemistry letters 2009;19(21):6189-91.
2009: MacMillan Karen S; Boger Dale L
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
Journal of medicinal chemistry 2009;52(19):5771-80.
2009: Swingle Mark R; Amable Lauren; Lawhorn Brian G; Buck Suzanne B; Burke Christopher P; Ratti Pukar; Fischer Kimberly L; Boger Dale L; Honkanen Richard E
Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.
The Journal of pharmacology and experimental therapeutics 2009;331(1):45-53.
2009: Kinsey S G; Long J Z; O'Neal S T; Abdullah R A; Poklis J L; Boger D L; Cravatt B F; Lichtman A H
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
The Journal of pharmacology and experimental therapeutics 2009;330(3):902-10.
2009: Mileni Mauro; Garfunkle Joie; DeMartino Jessica K; Cravatt Benjamin F; Boger Dale L; Stevens Raymond C
Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.
Journal of the American Chemical Society 2009;131(30):10497-506.
2009: Whitby Landon R; Lee Andrew M; Kunz Stefan; Oldstone Michael B A; Boger Dale L
Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis.
Bioorganic & medicinal chemistry letters 2009;19(14):3771-4.
2009: Clark Ryan C; Lee Sang Yeul; Searcey Mark; Boger Dale L
The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction.
Natural product reports 2009;26(4):465-77.
2009: Shaginian Alex; Whitby Landon R; Hong Sukwon; Hwang Inkyu; Farooqi Bilal; Searcey Mark; Chen Jiandong; Vogt Peter K; Boger Dale L
Design, Synthesis, and Evaluation of an alpha-Helix Mimetic Library Targeting Protein-Protein Interactions.
Journal of the American Chemical Society 2009;131(15):5564-72.
2009: Ishikawa Hayato; Colby David A; Seto Shigeki; Va Porino; Tam Annie; Kakei Hiroyuki; Rayl Thomas J; Hwang Inkyu; Boger Dale L
Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues.
Journal of the American Chemical Society 2009;131(13):4904-16.
2009: Schlosburg Joel E; Boger Dale L; Cravatt Benjamin F; Lichtman Aron H
Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.
The Journal of pharmacology and experimental therapeutics 2009;329(1):314-23.
2009: Crane Christine M; Boger Dale L
Synthesis and Evaluation of Vancomycin Aglycon Analogues That Bear Modifications in the N-Terminal d-Leucyl Amino Acid.
Journal of medicinal chemistry 2009;52(5):1471-6.
2009: MacMillan Karen S; Nguyen Trihn; Hwang Inkyu; Boger Dale L
Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.
Journal of the American Chemical Society 2009;131(3):1187-94.
2008: MacMillan Karen S; Boger Dale L
An additional spirocyclization for duocarmycin SA.
Journal of the American Chemical Society 2008;130(49):16521-3.
2008: Slaymaker Ian M; Bracey Michael; Mileni Mauro; Garfunkle Joie; Cravatt Benjamin F; Boger Dale L; Stevens Raymond C
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2008;18(22):5847-50.
2008: DeMartino Jessica K; Garfunkle Joie; Hochstatter Dustin G; Cravatt Benjamin F; Boger Dale L
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2008;18(22):5842-6.
2008: Clark Ryan C; Lee Sang Yeul; Boger Dale L
Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures.
Journal of the American Chemical Society 2008;130(37):12355-69.
2008: DeMartino Jessica K; Hwang Inkyu; Connelly Stephen; Wilson Ian A; Boger Dale L
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
Journal of medicinal chemistry 2008;51(17):5441-8.
2008: Garfunkle Joie; Ezzili Cyrine; Rayl Thomas J; Hochstatter Dustin G; Hwang Inkyu; Boger Dale L
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Journal of medicinal chemistry 2008;51(15):4392-403.
2008: Lee Andrew M; Rojek Jillian M; Spiropoulou Christina F; Gundersen Anette T; Jin Wei; Shaginian Alex; York Joanne; Nunberg Jack H; Boger Dale L; Oldstone Michael B A; Kunz Stefan
Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses.
The Journal of biological chemistry 2008;283(27):18734-42.
2008: Tichenor Mark S; Boger Dale L
Yatakemycin: total synthesis, DNA alkylation, and biological properties.
Natural product reports 2008;25(2):220-6.
2008: Lu Xiaohong; Vogt Peter K; Boger Dale L; Lunec John
Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization.
Oncology reports 2008;19(3):825-30.
2008: Kimball F Scott; Romero F Anthony; Ezzili Cyrine; Garfunkle Joie; Rayl Thomas J; Hochstatter Dustin G; Hwang Inkyu; Boger Dale L
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Journal of medicinal chemistry 2008;51(4):937-47.
2008: Ishikawa Hayato; Colby David A; Boger Dale L
Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine.
Journal of the American Chemical Society 2008;130(2):420-1.
2007: Jin Wei; Trzupek John D; Rayl Thomas J; Broward Melinda A; Vielhauer George A; Weir Scott J; Hwang Inkyu; Boger Dale L
A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.
Journal of the American Chemical Society 2007;129(49):15391-7.
2007: Tichenor Mark S; MacMillan Karen S; Stover James S; Wolkenberg Scott E; Pavani Maria G; Zanella Lorenzo; Zaid Abdel N; Spalluto Gianpiero; Rayl Thomas J; Hwang Inkyu; Baraldi Pier Giovanni; Boger Dale L
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Journal of the American Chemical Society 2007;129(45):14092-9.
2007: Tichenor Mark S; MacMillan Karen S; Trzupek John D; Rayl Thomas J; Hwang Inkyu; Boger Dale L
Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.
Journal of the American Chemical Society 2007;129(35):10858-69.
2007: Lee Sang Yeul; Clark Ryan C; Boger Dale L
Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.
Journal of the American Chemical Society 2007;129(32):9860-1.
2007: Nam Joonwoo; Shin Dongwoo; Rew Yosup; Boger Dale L
Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.
Journal of the American Chemical Society 2007;129(28):8747-55.
2007: Hardouin Christophe; Kelso Michael J; Romero F Anthony; Rayl Thomas J; Leung Donmienne; Hwang Inkyu; Cravatt Benjamin F; Boger Dale L
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Journal of medicinal chemistry 2007;50(14):3359-68.
2007: Xu Lan; Chong Youhoon; Hwang Inkyu; D'Onofrio Anthony; Amore Kristen; Beardsley G Peter; Li Chenglong; Olson Arthur J; Boger Dale L; Wilson Ian A
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
The Journal of biological chemistry 2007;282(17):13033-46.
2007: Romero F Anthony; Du Wu; Hwang Inkyu; Rayl Thomas J; Kimball F Scott; Leung Donmienne; Hoover Heather S; Apodaca Richard L; Breitenbucher J Guy; Cravatt Benjamin F; Boger Dale L
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.
Journal of medicinal chemistry 2007;50(5):1058-68.
2007: Eubanks Lisa M; Hixon Mark S; Jin Wei; Hong Sukwon; Clancy Colin M; Tepp William H; Baldwin Michael R; Malizio Carl J; Goodnough Michael C; Barbieri Joseph T; Johnson Eric A; Boger Dale L; Dickerson Tobin J; Janda Kim D
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2602-7.
2006: Lawhorn Brian G; Boga Sobhana B; Wolkenberg Scott E; Colby David A; Gauss Carla-Maria; Swingle Mark R; Amable Lauren; Honkanen Richard E; Boger Dale L
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
Journal of the American Chemical Society 2006;128(51):16720-32.
2006: Tichenor Mark S; Trzupek John D; Kastrinsky David B; Shiga Futoshi; Hwang Inkyu; Boger Dale L
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
Journal of the American Chemical Society 2006;128(49):15683-96.
2006: Romero F Anthony; Hwang Inkyu; Boger Dale L
Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors.
Journal of the American Chemical Society 2006;128(43):14004-5.
2006: Schnermann Martin J; Romero F Anthony; Hwang Inkyu; Nakamaru-Ogiso Eiko; Yagi Takao; Boger Dale L
Total synthesis of piericidin A1 and B1 and key analogues.
Journal of the American Chemical Society 2006;128(36):11799-807.
2006: Ishikawa Hayato; Elliott Gregory I; Velcicky Juraj; Choi Younggi; Boger Dale L
Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids.
Journal of the American Chemical Society 2006;128(32):10596-612.
2006: Elliott Gregory I; Fuchs James R; Blagg Brian S J; Ishikawa Hayato; Tao Houchao; Yuan Z-Q; Boger Dale L
Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles.
Journal of the American Chemical Society 2006;128(32):10589-95.
2006: DeMartino Jessica K; Hwang Inkyu; Xu Lan; Wilson Ian A; Boger Dale L
Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.
Journal of medicinal chemistry 2006;49(10):2998-3002.
2006: Crowley Brendan M; Boger Dale L
Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.
Journal of the American Chemical Society 2006;128(9):2885-92.
2006: Clark Ryan C; Pfeiffer Steven S; Boger Dale L
Diastereoselective Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: an asymmetric variant of the 1-azadiene Diels-Alder reaction.
Journal of the American Chemical Society 2006;128(8):2587-93.
2006: Trzupek John D; Gottesfeld Joel M; Boger Dale L
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
Nature chemical biology 2006;2(2):79-82.
2006: Hamasaki Akiyuki; Ducray Richard; Boger Dale L
Two novel 1,2,4,5-tetrazines that participate in inverse electron demand Diels-Alder reactions with an unexpected regioselectivity.
The Journal of organic chemistry 2006;71(1):185-93.
2006: Elliott Gregory I; Velcicky Juraj; Ishikawa Hayato; Li Yongkai; Boger Dale L
Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles.
Angewandte Chemie (International ed. in English) 2006;45(4):620-2.
2005: Guimarães Cristiano Ruch Werneck; Boger Dale L; Jorgensen William L
Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations.
Journal of the American Chemical Society 2005;127(49):17377-84.
2005: Schnermann Martin J; Boger Dale L
Total synthesis of piericidin A1 and B1.
Journal of the American Chemical Society 2005;127(45):15704-5.
2005: Chou Ting-Chao; Guan Yongbiao; Soenen Danielle R; Danishefsky Samuel J; Boger Dale L
Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice.
Cancer chemotherapy and pharmacology 2005;56(4):379-90.
2005: Choi Younggi; Ishikawa Hayato; Velcicky Juraj; Elliott Gregory I; Miller Michael M; Boger Dale L
Total synthesis of (-)- and ent-(+)-vindoline.
Organic letters 2005;7(20):4539-42.
2005: Hamasaki Akiyuki; Zimpleman Jeffrey M; Hwang Inkyu; Boger Dale L
Total synthesis of ningalin D.
Journal of the American Chemical Society 2005;127(30):10767-70.
2005: Capps Kevin J; Humiston Jon; Dominique Romyr; Hwang Inkyu; Boger Dale L
Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization.
Bioorganic & medicinal chemistry letters 2005;15(11):2840-4.
2005: Cheng Heng; Hwang Inkyu; Chong Youhoon; Tavassoli Ali; Webb Michael E; Zhang Yan; Wilson Ian A; Benkovic Stephen J; Boger Dale L
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2005;13(10):3593-9.
2005: Chong Youhoon; Hwang Inkyu; Tavassoli Ali; Zhang Yan; Wilson Ian A; Benkovic Stephen J; Boger Dale L
Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.
Bioorganic & medicinal chemistry 2005;13(10):3587-92.
2005: Cheng Heng; Chong Youhoon; Hwang Inkyu; Tavassoli Ali; Zhang Yan; Wilson Ian A; Benkovic Stephen J; Boger Dale L
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2005;13(10):3577-85.
2005: Tse Winston C; Boger Dale L
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2005;Chapter 8():Unit 8.5.
2005: Boger Dale L; Miyauchi Hiroshi; Du Wu; Hardouin Christophe; Fecik Robert A; Cheng Heng; Hwang Inkyu; Hedrick Michael P; Leung Donmienne; Acevedo Orlando; Guimarães Cristiano R W; Jorgensen William L; Cravatt Benjamin F
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
Journal of medicinal chemistry 2005;48(6):1849-56.
2005: Leung Donmienne; Du Wu; Hardouin Christophe; Cheng Heng; Hwang Inkyu; Cravatt Benjamin F; Boger Dale L
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.
Bioorganic & medicinal chemistry letters 2005;15(5):1423-8.
2005: Yuan Zhong Qing; Ishikawa Hayato; Boger Dale L
Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction.
Organic letters 2005;7(4):741-4.
2005: Walker Suzanne; Chen Lan; Hu Yanan; Rew Yosup; Shin Dongwoo; Boger Dale L
Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity.
Chemical reviews 2005;105(2):449-76.
2005: Du Wu; Hardouin Christophe; Cheng Heng; Hwang Inkyu; Boger Dale L
Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2005;15(1):103-6.
2004: Tse Winston C; Boger Dale L
Sequence-selective DNA recognition: natural products and nature's lessons.
Chemistry & biology 2004;11(12):1607-17.
2004: Tao Houchao; Hwang Inkyu; Boger Dale L
Multidrug resistance reversal activity of permethyl ningalin B amide derivatives.
Bioorganic & medicinal chemistry letters 2004;14(24):5979-81.
2004: Parrish Jay P; Trzupek John D; Hughes Terry V; Hwang Inkyu; Boger Dale L
Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.
Bioorganic & medicinal chemistry 2004;12(22):5845-56.
2004: Lichtman Aron H; Leung Donmienne; Shelton Christopher C; Saghatelian Alan; Hardouin Christophe; Boger Dale L; Cravatt Benjamin F
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity.
The Journal of pharmacology and experimental therapeutics 2004;311(2):441-8.
2004: Lee Patrick S; Du Wu; Boger Dale L; Jorgensen William L
Energetic preferences for alpha,beta versus beta,gamma unsaturation.
The Journal of organic chemistry 2004;69(16):5448-53.
2004: Ham Young-Wan; Boger Dale L
A powerful selection assay for mixture libraries of DNA alkylating agents.
Journal of the American Chemical Society 2004;126(30):9194-5.
2004: Shin Dongwoo; Rew Yosup; Boger Dale L
Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):11977-9.
2004: Lillo Antonietta M; Sun Chengzao; Gao Changshou; Ditzel Henrik; Parrish Jay; Gauss Carla-Marie; Moss Jason; Felding-Habermann Brunhilde; Wirsching Peter; Boger Dale L; Janda Kim D
A human single-chain antibody specific for integrin alpha3beta1 capable of cell internalization and delivery of antitumor agents.
Chemistry & biology 2004;11(7):897-906.
2004: Tichenor Mark S; Kastrinsky David B; Boger Dale L
Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin.
Journal of the American Chemical Society 2004;126(27):8396-8.
2004: Chen Lan; Yuan Yanqiu; Helm Jeremiah S; Hu Yanan; Rew Yosup; Shin Dongwoo; Boger Dale L; Walker Suzanne
Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics.
Journal of the American Chemical Society 2004;126(24):7462-3.
2004: Crowley Brendan M; Mori Yoshiki; McComas Casey C; Tang Datong; Boger Dale L
Total synthesis of the ristocetin aglycon.
Journal of the American Chemical Society 2004;126(13):4310-7.
2004: Kastrinsky David B; Boger Dale L
Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI).
The Journal of organic chemistry 2004;69(7):2284-9.
2004: Rew Yosup; Shin Dongwoo; Hwang Inkyu; Boger Dale L
Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity.
Journal of the American Chemical Society 2004;126(4):1041-3.
2004: Tse Winston C; Boger Dale L
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity.
Accounts of chemical research 2004;37(1):61-9.
2004: Parrish Jay P; Hughes Terry V; Hwang Inkyu; Boger Dale L
Establishing the parabolic relationship between reactivity and activity for derivatives and analogues of the duocarmycin and CC-1065 alkylation subunits.
Journal of the American Chemical Society 2004;126(1):80-1.
2003: Desai Pankaj; Pfeiffer Steven S; Boger Dale L
Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry.
Organic letters 2003;5(26):5047-50.
2003: Buck Suzanne B; Hardouin Christophe; Ichikawa Satoshi; Soenen Danielle R; Gauss C-M; Hwang Inkyu; Swingle Mark R; Bonness Kathy M; Honkanen Richard E; Boger Dale L
Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.
Journal of the American Chemical Society 2003;125(51):15694-5.
2003: Bassarello Carla; Cimino Paola; Bifulco Giuseppe; Boger Dale L; Smith Jarrod A; Chazin Walter J; Gomez-Paloma Luigi
NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex.
Chembiochem : a European journal of chemical biology 2003;4(11):1188-93.
2003: Parrish Jay P; Kastrinsky David B; Hwang Inkyu; Boger Dale L
Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) alkylation subunit.
The Journal of organic chemistry 2003;68(23):8984-90.
2003: Ham Young-Wan; Tse Winston C; Boger Dale L
High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay.
Bioorganic & medicinal chemistry letters 2003;13(21):3805-7.
2003: Yeung Bryan K S; Tse Winston C; Boger Dale L
Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay.
Bioorganic & medicinal chemistry letters 2003;13(21):3801-4.
2003: Desharnais Joel; Hwang Inkyu; Zhang Yan; Tavassoli Ali; Baboval Justin; Benkovic Stephen J; Wilson Ian A; Boger Dale L
Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2003;11(20):4511-21.
2003: Marsilje Thomas H; Hedrick Michael P; Desharnais Joel; Capps Kevin; Tavassoli Ali; Zhang Yan; Wilson Ian A; Benkovic Stephen J; Boger Dale L
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
Bioorganic & medicinal chemistry 2003;11(20):4503-9.
2003: Marsilje Thomas H; Hedrick Michael P; Desharnais Joel; Tavassoli Ali; Zhang Yan; Wilson Ian A; Benkovic Stephen J; Boger Dale L
Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Bioorganic & medicinal chemistry 2003;11(20):4487-501.
2003: Tse Winston C; Ishii Takahiro; Boger Dale L
Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay.
Bioorganic & medicinal chemistry 2003;11(20):4479-86.
2003: McComas Casey C; Crowley Brendan M; Hwang Inkyu; Boger Dale L
Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.
Bioorganic & medicinal chemistry letters 2003;13(17):2933-6.
2003: Boger Dale L; Desharnais Joel; Capps Kevin
Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions.
Angewandte Chemie (International ed. in English) 2003;42(35):4138-76.
2003: Parrish Jay P; Kastrinsky David B; Wolkenberg Scott E; Igarashi Yasuhiro; Boger Dale L
DNA alkylation properties of yatakemycin.
Journal of the American Chemical Society 2003;125(36):10971-6.
2003: Parrish Jay P; Kastrinsky David B; Stauffer Frederic; Hedrick Michael P; Hwang Inkyu; Boger Dale L
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Bioorganic & medicinal chemistry 2003;11(17):3815-38.
2003: McComas Casey C; Crowley Brendan M; Boger Dale L
Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions.
Journal of the American Chemical Society 2003;125(31):9314-5.
2003: Parrish Jay P; Kastrinsky David B; Boger Dale L
Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone.
Organic letters 2003;5(14):2577-9.
2003: Yeung Bryan K S; Boger Dale L
Synthesis of isochrysohermidin-distamycin hybrids.
The Journal of organic chemistry 2003;68(13):5249-53.
2003: Leung Donmienne; Hardouin Christophe; Boger Dale L; Cravatt Benjamin F
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.
Nature biotechnology 2003;21(6):687-91.
2003: Zhang Yan; Desharnais Joel; Marsilje Thomas H; Li Chenglong; Hedrick Michael P; Gooljarsingh Lata T; Tavassoli Ali; Benkovic Stephen J; Olson Arthur J; Boger Dale L; Wilson Ian A
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
Biochemistry 2003;42(20):6043-56.
2003: Soenen Danielle R; Hwang Inkyu; Hedrick Michael P; Boger Dale L
Multidrug resistance reversal activity of key ningalin analogues.
Bioorganic & medicinal chemistry letters 2003;13(10):1777-81.
2003: Soenen Danielle R; Zimpleman Jeffrey M; Boger Dale L
Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine.
The Journal of organic chemistry 2003;68(9):3593-8.
2003: Boger Dale L
Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions.
Bioorganic & medicinal chemistry 2003;11(8):1607-13.
2003: Wanner Jutta; Tang Datong; McComas Casey C; Crowley Brendan M; Jiang Wanlong; Moss Jason; Boger Dale L
A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin.
Bioorganic & medicinal chemistry letters 2003;13(6):1169-73.
2003: Jiang Wanlong; Wanner Jutta; Lee Richard J; Bounaud Pierre-Yves; Boger Dale L
Total synthesis of the ramoplanin A2 and ramoplanose aglycon.
Journal of the American Chemical Society 2003;125(7):1877-87.
2002: Zhang Yan; Desharnais Joel; Greasley Samantha E; Beardsley G Peter; Boger Dale L; Wilson Ian A
Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
Biochemistry 2002;41(48):14206-15.
2002: Ambroise Yves; Yaspan Brian; Ginsberg Mark H; Boger Dale L
Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries.
Chemistry & biology 2002;9(11):1219-26.
2002: Lewy D S; Gauss C-M; Soenen D R; Boger D L
Fostriecin: chemistry and biology.
Current medicinal chemistry 2002;9(22):2005-32.
2002: Wolkenberg Scott E; Boger Dale L
Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole.
The Journal of organic chemistry 2002;67(21):7361-4.
2002: Wilkie Gordon D; Elliott Gregory I; Blagg Brian S J; Wolkenberg Scott E; Soenen Danielle R; Miller Michael M; Pollack Scott; Boger Dale L
Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles.
Journal of the American Chemical Society 2002;124(38):11292-4.
2002: Woods Craig R; Ishii Takahiro; Boger Dale L
Synthesis and DNA binding properties of iminodiacetic acid-linked polyamides: characterization of cooperative extended 2:1 side-by-side parallel binding.
Journal of the American Chemical Society 2002;124(36):10676-82.
2002: Woods Craig R; Faucher Nicolas; Eschgfaller Bernd; Bair Kenneth W; Boger Dale L
Synthesis and DNA binding properties of saturated distamycin analogues.
Bioorganic & medicinal chemistry letters 2002;12(18):2647-50.
2002: Marsilje Thomas H; Labroli Marc A; Hedrick Michael P; Jin Qing; Desharnais Joel; Baker Stephen J; Gooljarsingh Lata T; Ramcharan Joseph; Tavassoli Ali; Zhang Yan; Wilson Ian A; Beardsley G Peter; Benkovic Stephen J; Boger Dale L
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2002;10(8):2739-49.
2002: Wolkenberg Scott E; Boger Dale L
Mechanisms of in situ activation for DNA-targeting antitumor agents.
Chemical reviews 2002;102(7):2477-95.
2002: Chen Yan; Bilban Melitta; Foster Carolyn A; Boger Dale L
Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides.
Journal of the American Chemical Society 2002;124(19):5431-40.
2002: Jiang Wanlong; Wanner Jutta; Lee Richard J; Bounaud Pierre-Yves; Boger Dale L
Total synthesis of the ramoplanin A2 and ramoplanose aglycon.
Journal of the American Chemical Society 2002;124(19):5288-90.
2002: McAtee J Jeffrey; Castle Steven L; Jin Qing; Boger Dale L
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
Bioorganic & medicinal chemistry letters 2002;12(9):1319-22.
2002: Berg Thorsten; Cohen Steven B; Desharnais Joel; Sonderegger Corinna; Maslyar Daniel J; Goldberg Joel; Boger Dale L; Vogt Peter K
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3830-5.
2002: Woods Craig R; Ishii Takahiro; Wu Bing; Bair Kenneth W; Boger Dale L
Hairpin versus extended DNA binding of a substituted beta-alanine linked polyamide.
Journal of the American Chemical Society 2002;124(10):2148-52.
2002: Ambroise Yves; Boger Dale L
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.
Bioorganic & medicinal chemistry letters 2002;12(3):303-6.
2002: Goldberg Joel; Jin Qing; Ambroise Yves; Satoh Shigeki; Desharnais Joel; Capps Kevin; Boger Dale L
Erythropoietin mimetics derived from solution phase combinatorial libraries.
Journal of the American Chemical Society 2002;124(4):544-55.
2001: Greasley S E; Marsilje T H; Cai H; Baker S; Benkovic S J; Boger D L; Wilson I A
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
Biochemistry 2001;40(45):13538-47.
2001: Boger D L; Schmitt H W; Fink B E; Hedrick M P
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
The Journal of organic chemistry 2001;66(20):6654-61.
2001: Fedorova I; Hashimoto A; Fecik R A; Hedrick M P; Hanus L O; Boger D L; Rice K C; Basile A S
Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems.
The Journal of pharmacology and experimental therapeutics 2001;299(1):332-42.
2001: Boger D L
Vancomycin, teicoplanin, and ramoplanin: synthetic and mechanistic studies.
Medicinal research reviews 2001;21(5):356-81.
2001: Ellis D A; Wolkenberg S E; Boger D L
Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis.
Journal of the American Chemical Society 2001;123(38):9299-306.
2001: Boger D L; Tse W C
Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules.
Bioorganic & medicinal chemistry 2001;9(9):2511-8.
2001: Boger D L; Hong J
Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration.
Journal of the American Chemical Society 2001;123(35):8515-9.
2001: Boger D L; Stauffer F; Hedrick M P
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Bioorganic & medicinal chemistry letters 2001;11(15):2021-4.
2001: Boger D L; Brunette S R; Garbaccio R M
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
The Journal of organic chemistry 2001;66(15):5163-73.
2001: Boger D L; Fink B E; Brunette S R; Tse W C; Hedrick M P
A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.
Journal of the American Chemical Society 2001;123(25):5878-91.
2001: Boger D L; Miyauchi H; Hedrick M P
alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.
Bioorganic & medicinal chemistry letters 2001;11(12):1517-20.
2001: Boger D L; Ichikawa S; Zhong W
Total synthesis of fostriecin (CI-920).
Journal of the American Chemical Society 2001;123(18):4161-7.
2001: Boger D L; Hughes T V; Hedrick M P
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
The Journal of organic chemistry 2001;66(7):2207-16.
2001: Boger D L; Kim S H; Mori Y; Weng J H; Rogel O; Castle S L; McAtee J J
First and second generation total synthesis of the teicoplanin aglycon.
Journal of the American Chemical Society 2001;123(9):1862-71.
2001: Boger D L; Goldberg J
Cytokine receptor dimerization and activation: prospects for small molecule agonists.
Bioorganic & medicinal chemistry 2001;9(3):557-62.
2001: Boger D L; Goldberg J; Silletti S; Kessler T; Cheresh D A
Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3).
Journal of the American Chemical Society 2001;123(7):1280-8.
2001: Boger D L; Ichikawa S; Tse W C; Hedrick M P; Jin Q
Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties.
Journal of the American Chemical Society 2001;123(4):561-8.
2001: Silletti S; Kessler T; Goldberg J; Boger D L; Cheresh D A
Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):119-24.
2000: Boger D L; Wolkenberg S E
Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine.
The Journal of organic chemistry 2000;65(26):9120-4.
2000: Boger D L; Fecik R A; Patterson J E; Miyauchi H; Patricelli M P; Cravatt B F
Fatty acid amide hydrolase substrate specificity.
Bioorganic & medicinal chemistry letters 2000;10(23):2613-6.
2000: Boger D L; Lee R J; Bounaud P Y; Meier P
Asymmetric synthesis of orthogonally protected L-threo-beta-hydroxyasparagine.
The Journal of organic chemistry 2000;65(20):6770-2.
2000: Boger D L; Lee J K
Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis.
The Journal of organic chemistry 2000;65(19):5996-6000.
2000: Boger D L; Dechantsreiter M A; Ishii T; Fink B E; Hedrick M P
Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents.
Bioorganic & medicinal chemistry 2000;8(8):2049-57.
2000: Boger D L; Chen Y; Foster C A
Synthesis and evaluation of aza HUN-7293.
Bioorganic & medicinal chemistry letters 2000;10(15):1741-4.
2000: Smith J A; Bifulco G; Case D A; Boger D L; Gomez-Paloma L; Chazin W J
The structural basis for in situ activation of DNA alkylation by duocarmycin SA.
Journal of molecular biology 2000;300(5):1195-204.
2000: Boger D L; Marsilje T H; Castro R A; Hedrick M P; Jin Q; Baker S J; Shim J H; Benkovic S J
Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Bioorganic & medicinal chemistry letters 2000;10(13):1471-5.
2000: Boger D L; Santillán A; Searcey M; Brunette S R; Wolkenberg S E; Hedrick M P; Jin Q
Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
The Journal of organic chemistry 2000;65(13):4101-11.
2000: Boger D L; Boyce C W
Selective metal cation activation of a DNA alkylating agent: synthesis and evaluation of methyl 1,2,9, 9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI).
The Journal of organic chemistry 2000;65(13):4088-100.
2000: Boger D L; Labroli M A; Marsilje T H; Jin Q; Hedrick M P; Baker S J; Shim J H; Benkovic S J
Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.
Bioorganic & medicinal chemistry 2000;8(5):1075-86.
2000: Boger D L; Fink B E; Hedrick M P
A new class of highly cytotoxic diketopiperazines.
Bioorganic & medicinal chemistry letters 2000;10(10):1019-20.
2000: Boger D L; Sato H; Lerner A E; Hedrick M P; Fecik R A; Miyauchi H; Wilkie G D; Austin B J; Patricelli M P; Cravatt B F
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5044-9.
2000: Boger D L; Soenen D R; Boyce C W; Hedrick M P; Jin Q
Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents.
The Journal of organic chemistry 2000;65(8):2479-83.
2000: Boger D L; Lee J K; Goldberg J; Jin Q
Two comparisons of the performance of positional scanning and deletion synthesis for the identification of active constituents in mixture combinatorial libraries.
The Journal of organic chemistry 2000;65(5):1467-74.
2000: Boger D L; Searcey M; Tse W C; Jin Q
Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
Bioorganic & medicinal chemistry letters 2000;10(5):495-8.
1999: Greasley S E; Yamashita M M; Cai H; Benkovic S J; Boger D L; Wilson I A
New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
Biochemistry 1999;38(51):16783-93.
1999: Baraldi P G; Cacciari B; Romagnoli R; Spalluto G; Boyce C W; Boger D L
Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity.
Bioorganic & medicinal chemistry letters 1999;9(21):3087-92.
1999: Boger D L; Sato H; Lerner A E; Guan X; Gilula N B
Arachidonic acid amide inhibitors of gap junction cell-cell communication.
Bioorganic & medicinal chemistry letters 1999;9(8):1151-4.
1999: Boger D L; Saionz K W
DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore.
Bioorganic & medicinal chemistry 1999;7(2):315-21.
1999: Boger D L; Sato H; Lerner A E; Austin B J; Patterson J E; Patricelli M P; Cravatt B F
Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition.
Bioorganic & medicinal chemistry letters 1999;9(2):265-70.
1998: Boger D L; Ducray P; Chai W; Jiang W; Goldberg J
Higher order iminodiacetic acid libraries for probing protein-protein interactions.
Bioorganic & medicinal chemistry letters 1998;8(17):2339-44.
1998: Boger D L; Henriksen S J; Cravatt B F
Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules.
Current pharmaceutical design 1998;4(4):303-14.
1998: Boger D L; Goldberg J; Jiang W; Chai W; Ducray P; Lee J K; Ozer R S; Andersson C M
Higher order iminodiacetic acid libraries for probing protein-protein interactions.
Bioorganic & medicinal chemistry 1998;6(8):1347-78.
1998: Boger D L; Kochanny M J; Cai H; Wyatt D; Kitos P A; Warren M S; Ramcharan J; Gooljarsingh L T; Benkovic S J
Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.
Bioorganic & medicinal chemistry 1998;6(6):643-59.
1998: Boger D L; Beresis R T; Loiseleur O; Wu J H; Castle S L
Synthesis of the vancomycin CDE ring system.
Bioorganic & medicinal chemistry letters 1998;8(7):721-4.
1998: Boger D L; Patterson J E; Guan X; Cravatt B F; Lerner R A; Gilula N B
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4810-5.
1998: Boger D L; Patterson J E; Jin Q
Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4102-7.
1998: Patricelli M P; Patterson J E; Boger D L; Cravatt B F
An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 1998;8(6):613-8.
1998: Boger D L; Chen J H; Saionz K W; Jin Q
Synthesis of key sandramycin analogs: systematic examination of the intercalation chromophore.
Bioorganic & medicinal chemistry 1998;6(1):85-102.
1997: Guan X; Cravatt B F; Ehring G R; Hall J E; Boger D L; Lerner R A; Gilula N B
The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells.
The Journal of cell biology 1997;139(7):1785-92.
1997: Boger D L; Haynes N E; Warren M S; Ramcharan J; Kitos P A; Benkovic S J
Multisubstrate analogue based on 5,8,10-trideazafolate.
Bioorganic & medicinal chemistry 1997;5(9):1853-7.
1997: Boger D L; Haynes N E; Warren M S; Ramcharan J; Marolewski A E; Kitos P A; Benkovic S J
Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.
Bioorganic & medicinal chemistry 1997;5(9):1847-52.
1997: Boger D L; Haynes N E; Warren M S; Ramcharan J; Kitos P A; Benkovic S J
Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase.
Bioorganic & medicinal chemistry 1997;5(9):1839-46.
1997: Boger D L; Haynes N E; Warren M S; Gooljarsingh L T; Ramcharan J; Kitos P A; Benkovic S J
Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase.
Bioorganic & medicinal chemistry 1997;5(9):1831-8.
1997: Boger D L; Haynes N E; Kitos P A; Warren M S; Ramcharan J; Marolewski A E; Benkovic S J
10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase.
Bioorganic & medicinal chemistry 1997;5(9):1817-30.
1997: Eis P S; Smith J A; Rydzewski J M; Case D A; Boger D L; Chazin W J
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA.
Journal of molecular biology 1997;272(2):237-52.
1997: Boger D L; Teramoto S; Cai H
N-methyl threonine analogues of deglycobleomycin A2: synthesis and evaluation.
Bioorganic & medicinal chemistry 1997;5(8):1577-89.
1997: Boger D L; Garbaccio R M
Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation.
Bioorganic & medicinal chemistry 1997;5(2):263-76.
1997: Boger D L; Han N
CC-1065/duocarmycin and bleomycin A2 hybrid agents: lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits.
Bioorganic & medicinal chemistry 1997;5(2):233-43.
1996: Cravatt B F; Giang D K; Mayfield S P; Boger D L; Lerner R A; Gilula N B
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides.
Nature 1996;384(6604):83-7.
1996: Boger D L; Zhou J
Key analogues of the tetrapeptide subunit of RA-VII and deoxybouvardin.
Bioorganic & medicinal chemistry 1996;4(10):1597-603.
1996: Boger D L; Zhou J; Cai H
Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: noncovalent binding coincidental with alkylation.
Bioorganic & medicinal chemistry 1996;4(6):859-67.
1996: Cheng S; Tarby C M; Comer D D; Williams J P; Caporale L H; Myers P L; Boger D L
A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template.
Bioorganic & medicinal chemistry 1996;4(5):727-37.
1996: Boger D L; Ramsey T M; Cai H
Synthesis and evaluation of potential N pi and N sigma metal chelation sites within the beta-hydroxy-L-histidine subunit of bleomycin A2: functional characterization of imidazole N pi metal complexation.
Bioorganic & medicinal chemistry 1996;4(2):195-207.
1996: Boger D L; Teramoto S; Cai H
Synthesis and evaluation of deglycobleomycin A2 analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: direct functional characterization of the requirement for secondary amide metal complexation.
Bioorganic & medicinal chemistry 1996;4(2):179-93.
1995: Boger D L; Zhou J; Winter B; Kitos P A
Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin.
Bioorganic & medicinal chemistry 1995;3(12):1579-93.
1995: Boger D L; Yun W; Han N
1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation.
Bioorganic & medicinal chemistry 1995;3(11):1429-53.
1995: Boger D L; Colletti S L; Teramoto S; Ramsey T M; Zhou J
Synthesis of key analogs of bleomycin A2 that permit a systematic evaluation of the linker region: identification of an exceptionally prominent role for the L-threonine substituent.
Bioorganic & medicinal chemistry 1995;3(9):1281-95.
1995: Cravatt B F; Prospero-Garcia O; Siuzdak G; Gilula N B; Henriksen S J; Boger D L; Lerner R A
Chemical characterization of a family of brain lipids that induce sleep.
Science (New York, N.Y.) 1995;268(5216):1506-9.
1995: Boger D L; Yun W; Cai H; Han N
CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit.
Bioorganic & medicinal chemistry 1995;3(6):761-7.
1995: Boger D L; Yun W; Han N; Johnson D S
CC-1065 CBI analogs: an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions.
Bioorganic & medicinal chemistry 1995;3(6):611-21.
1995: Boger D L; Johnson D S
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3642-9.
1995: Boger D L; Nishi T
Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: development of a divergent strategy for the total synthesis of duocarmycins A and SA.
Bioorganic & medicinal chemistry 1995;3(1):67-77.
1994: Lerner R A; Siuzdak G; Prospero-Garcia O; Henriksen S J; Boger D L; Cravatt B F
Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9505-8.
1994: Boger D L; Patane M A; Jin Q; Kitos P A
Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs.
Bioorganic & medicinal chemistry 1994;2(2):85-100.
1994: Boger D L; Johnson D S; Yun W; Tarby C M
Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity.
Bioorganic & medicinal chemistry 1994;2(2):115-35.
1994: Mohamadi F; Spees M M; Staten G S; Marder P; Kipka J K; Johnson D A; Boger D L; Zarrinmayeh H
Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits.
Journal of medicinal chemistry 1994;37(2):232-9.
1993: Boger D L; Johnson D S; Palanki M S; Kitos P A; Chang J; Dowell P
Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit.
Bioorganic & medicinal chemistry 1993;1(1):27-38.
1991: Boger D L; Zarrinmayeh H; Munk S A; Kitos P A; Suntornwat O
Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1431-5.
1990: Boger D L; Invergo B J; Coleman R S; Zarrinmayeh H; Kitos P A; Thompson S C; Leong T; McLaughlin L W
A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding.
Chemico-biological interactions 1990;73(1):29-52.
1987: Boger D L; Yasuda M; Mitscher L A; Drake S D; Kitos P A; Thompson S C
Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones.
Journal of medicinal chemistry 1987;30(10):1918-28.
1985: Boger D L; Mitscher L A; Mullican M D; Drake S D; Kitos P
Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol.
Journal of medicinal chemistry 1985;28(10):1543-7.

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