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Fritz Sörgel

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Fabian Higel; Andreas Seidl; Uwe Demelbauer; Wolfgang Friess; Fritz Sörgel
Reversed-phase liquid-chromatographic mass spectrometric N-glycan analysis of biopharmaceuticals.
W H F Goessens; Martina Kinzig; Johan W Mouton; Fritz Sörgel; Marian T ten Kate; Irma A J M Bakker-Woudenberg
The therapeutic effect of tigecycline, unlike that of Ceftazidime, is not influenced by whether the Klebsiella pneumoniae strain produces extended-spectrum β-lactamases in experimental pneumonia in rats.
Cornelia Landersdorfer; Ulrich Stephan; Jürgen Bulitta; George L Drusano; Ulrike Holzgrabe; Martina Kinzig; Carl M J Kirkpatrick; Fritz Sörgel
Population pharmacokinetics of piperacillin at two dose levels: influence of nonlinear pharmacokinetics on the pharmacodynamic profile.

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2013: Fabian Higel; Andreas Seidl; Uwe Demelbauer; Wolfgang Friess; Fritz Sörgel
Reversed-phase liquid-chromatographic mass spectrometric N-glycan analysis of biopharmaceuticals.
Analytical and bioanalytical chemistry 2013;405(8):2481-93.
2013: W H F Goessens; Martina Kinzig; Johan W Mouton; Fritz Sörgel; Marian T ten Kate; Irma A J M Bakker-Woudenberg
The therapeutic effect of tigecycline, unlike that of Ceftazidime, is not influenced by whether the Klebsiella pneumoniae strain produces extended-spectrum β-lactamases in experimental pneumonia in rats.
Antimicrobial agents and chemotherapy 2013;57(1):643-6.
2012: Cornelia Landersdorfer; Ulrich Stephan; Jürgen Bulitta; George L Drusano; Ulrike Holzgrabe; Martina Kinzig; Carl M J Kirkpatrick; Fritz Sörgel
Population pharmacokinetics of piperacillin at two dose levels: influence of nonlinear pharmacokinetics on the pharmacodynamic profile.
Antimicrobial agents and chemotherapy 2012;56(11):5715-23.
2012: Marija Djukic; Helmut Eiffert; Ulrike Holzgrabe; Martin Munz; Fritz Sörgel; Roland Nau
Overton's rule helps to estimate the penetration of anti-infectives into patients' cerebrospinal fluid.
Antimicrobial agents and chemotherapy 2012;56(2):979-88.
2011: Paul W Elsinghorst; Martina Kinzig; Michael Rodamer; Ulrike Holzgrabe; Fritz Sörgel
An LC-MS/MS procedure for the quantification of naproxen in human plasma: development, validation, comparison with other methods, and application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(19):1686-96.
2011: Jürgen Bulitta; Martina Kinzig; Cornelia Landersdorfer; Ulrike Holzgrabe; U Stephan; Fritz Sörgel
Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers.
Antimicrobial agents and chemotherapy 2011;55(6):2927-36.
2011: Michael Rodamer; Paul W Elsinghorst; Martina Kinzig; Michael Gütschow; Fritz Sörgel
Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of sunitinib (SU11248) and its active metabolite, N-desethyl sunitinib (SU12662), in human plasma: application to an explorative study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(11-12):695-706.
2011: Jürgen Bulitta; Martina Kinzig; Cornelia Landersdorfer; Christoph K Naber; Christian Sauber; Fritz Sörgel; F M E Wagenlehner; Kurt G Naber
Population pharmacokinetics and penetration into prostatic, seminal, and vaginal fluid for ciprofloxacin, levofloxacin, and their combination.
Chemotherapy 2011;57(5):402-16.
2011: F Kanefendt; A Lindauer; Martina Kinzig; D Strumberg; Max E Scheulen; K Mross; R Fischer; B Moritz; Fritz Sörgel; Ulrich Jaehde
Biomarker response on exposure to sunitinib and its primary metabolite (SU12662) in metastatic colorectal cancer patients.
International journal of clinical pharmacology and therapeutics 2011;49(1):88-90.
2011: Claudia Lengerke; Michael Haap; Frank Mayer; Lothar Kanz; Martina Kinzig; Ulrike Schumacher; Fritz Sörgel; Reimer Riessen
Low tigecycline concentrations in the cerebrospinal fluid of a neutropenic patient with inflamed meninges.
Antimicrobial agents and chemotherapy 2011;55(1):449-50.
2010: Fritz Sörgel; Helmut Lerch; Thomas Lauber
Physicochemical and biologic comparability of a biosimilar granulocyte colony-stimulating factor with its reference product.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2010;24(6):347-57.
2010: Nadine Nagy; Till Freudenberger; Ariane Melchior-Becker; Katharina Röck; Michael Ter Braak; Holger Jastrow; Martina Kinzig; Susann Lucke; Tatsiana Suvorava; Georg Kojda; Artur A Weber; Fritz Sörgel; Bodo Levkau; Süleyman Ergün; Jens W Fischer
Inhibition of hyaluronan synthesis accelerates murine atherosclerosis: novel insights into the role of hyaluronan synthesis.
Circulation 2010;122(22):2313-22.
2010: Jürgen Bulitta; Martina Kinzig; Verena Jakob; Ulrike Holzgrabe; Fritz Sörgel; Nicholas H G Holford
Nonlinear pharmacokinetics of piperacillin in healthy volunteers--implications for optimal dosage regimens.
British journal of clinical pharmacology 2010;70(5):682-93.
2010: Lois S Lee; Martina Kinzig; Anne N Nafziger; Lei Ma; Fritz Sörgel; Ronald N Jones; George L Drusano; Joseph S Bertino
Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.
Diagnostic microbiology and infectious disease 2010;68(3):251-8.
2010: Richard Stanhope; Fritz Sörgel; Patricia Gravel; Yannic B Pannatier Schuetz; Markus Zabransky; Michael Muenzberg
Bioequivalence studies of omnitrope, the first biosimilar/rhGH follow-on protein: two comparative phase 1 randomized studies and population pharmacokinetic analysis.
Journal of clinical pharmacology 2010;50(11):1339-48.
2010: Roland Nau; Fritz Sörgel; Helmut Eiffert
Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections.
Clinical microbiology reviews 2010;23(4):858-83.
2010: J B Bulitta; Cornelia Landersdorfer; S J Hüttner; G L Drusano; Martina Kinzig; U Holzgrabe; U Stephan; Fritz Sörgel
Population pharmacokinetic comparison and pharmacodynamic breakpoints of ceftazidime in cystic fibrosis patients and healthy volunteers.
Antimicrobial agents and chemotherapy 2010;54(3):1275-82.
2010: Cornelia Landersdorfer; Carl M J Kirkpatrick; Martina Kinzig; Jürgen Bulitta; Ulrike Holzgrabe; Ulrich Jaehde; Andreas Reiter; Kurt G Naber; Michael Rodamer; Fritz Sörgel
Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid.
British journal of clinical pharmacology 2010;69(2):167-78.
2009: Jürgen B Bulitta; Stephen B Duffull; Cornelia Landersdorfer; Martina Kinzig; Ulrike Holzgrabe; Ulrich Stephan; George L Drusano; Fritz Sörgel
Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers.
Diagnostic microbiology and infectious disease 2009;65(2):130-41.
2009: Cornelia Landersdorfer; Carl M J Kirkpatrick; Martina Kinzig; Jürgen Bulitta; Ulrike Holzgrabe; George L Drusano; Fritz Sörgel
Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.
Antimicrobial agents and chemotherapy 2009;53(9):3902-7.
2009: Shekman L Wong; Fritz Sörgel; Martina Kinzig; Michael R Goldberg; Michael M Kitt; Steven L Barriere
Lack of pharmacokinetic drug interactions following concomitant administration of telavancin with aztreonam or piperacillin/tazobactam in healthy participants.
Journal of clinical pharmacology 2009;49(7):816-23.
2009: Khaled Abduljalil; Martina Kinzig; Jürgen Bulitta; Stefan Horkovics-Kovats; Fritz Sörgel; Michael Rodamer; Uwe Fuhr
Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration.
Antimicrobial agents and chemotherapy 2009;53(7):2892-901.
2009: Cornelia Landersdorfer; Martina Kinzig; Jürgen Bulitta; Friedrich F Hennig; Ulrike Holzgrabe; Fritz Sörgel; Johannes Gusinde
Bone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation.
Antimicrobial agents and chemotherapy 2009;53(6):2569-78.
2009: Cornelia Landersdorfer; Martina Kinzig; Friedrich F Hennig; Jürgen Bulitta; Ulrike Holzgrabe; George L Drusano; Fritz Sörgel; Johannes Gusinde
Penetration of moxifloxacin into bone evaluated by Monte Carlo simulation.
Antimicrobial agents and chemotherapy 2009;53(5):2074-81.
2009: Alexander Jetter; Martina Kinzig; Michael Rodamer; Dorota Tomalik-Scharte; Fritz Sörgel; Uwe Fuhr
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?
European journal of clinical pharmacology 2009;65(4):411-7.
2009: Oxana Doroshyenko; Uwe Fuhr; Daria Kunz; Dorothee Frank; Martina Kinzig; Alexander Jetter; Yvonne Reith; Andreas Lazar; Dirk Taubert; Julia Kirchheiner; Matthias Baum; Gerhard Eisenbrand; Franz-Ingo Berger; Daniel Bertow; Albrecht Berkessel; Fritz Sörgel; Edgar Schömig; Dorota Tomalik-Scharte
In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(2):433-43.
2009: Fritz Sörgel; Ursula Thyroff-Friesinger; Andrea Vetter; Bernhard Vens-Cappell; Martina Kinzig
Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial.
BMC clinical pharmacology 2009;9():10.
2009: Cornelia Landersdorfer; Jürgen Bulitta; Martina Kinzig; Ulrike Holzgrabe; Fritz Sörgel
Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations.
Clinical pharmacokinetics 2009;48(2):89-124.
2009: Fritz Sörgel; Ursula Thyroff-Friesinger; Andrea Vetter; Bernhard Vens-Cappell; Martina Kinzig
Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple subcutaneous administrations.
Pharmacology 2009;83(2):122-30.
2008: Cornelia Landersdorfer; Carl M J Kirkpatrick; Martina Kinzig; Jürgen Bulitta; Ulrike Holzgrabe; Fritz Sörgel
Inhibition of flucloxacillin tubular renal secretion by piperacillin.
British journal of clinical pharmacology 2008;66(5):648-59.
2008: George L Drusano; Olanrewaju O Okusanya; Adedoyin Okusanya; Brian Van Scoy; D L Brown; Robert Kulawy; Fritz Sörgel; Henry S Heine; Arnold Louie
Is 60 days of ciprofloxacin administration necessary for postexposure prophylaxis for Bacillus anthracis?
Antimicrobial agents and chemotherapy 2008;52(11):3973-9.
2008: Fritz Sörgel
[The usefulness of hair analysis?].
Medizinische Monatsschrift für Pharmazeuten 2008;31(10):393.
2008: Thomas P Lodise; Martina Kinzig; George L Drusano; Ulrich Loos; Friedrich Vogel; Jürgen Bulitta; Markus Hinder; Fritz Sörgel
Use of population pharmacokinetic modeling and Monte Carlo simulation to describe the pharmacodynamic profile of cefditoren in plasma and epithelial lining fluid.
Antimicrobial agents and chemotherapy 2008;52(6):1945-51.
2007: Thomas P Lodise; R Nau; Martina Kinzig; George L Drusano; Ronald Jones; Fritz Sörgel
Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation.
The Journal of antimicrobial chemotherapy 2007;60(5):1038-44.
2007: Samir G Sakka; Anna K Glauner; Jürgen Bulitta; Martina Kinzig; Wolfgang Pfister; George L Drusano; Fritz Sörgel
Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial.
Antimicrobial agents and chemotherapy 2007;51(9):3304-10.
2007: Cornelia Landersdorfer; Carl M J Kirkpatrick; Martina Kinzig; Jürgen Bulitta; Ulrike Holzgrabe; George L Drusano; Fritz Sörgel
Population pharmacokinetics at two dose levels and pharmacodynamic profiling of flucloxacillin.
Antimicrobial agents and chemotherapy 2007;51(9):3290-7.
2007: Thomas P Lodise; Roland Nau; Martina Kinzig; Ronald Jones; George L Drusano; Fritz Sörgel
Comparison of the probability of target attainment between ceftriaxone and cefepime in the cerebrospinal fluid and serum against Streptococcus pneumoniae.
Diagnostic microbiology and infectious disease 2007;58(4):445-52.
2007: Jürgen Bulitta; S B Duffull; Martina Kinzig; Ulrike Holzgrabe; U Stephan; George L Drusano; Fritz Sörgel
Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers.
Antimicrobial agents and chemotherapy 2007;51(7):2497-507.
2006: F M E Wagenlehner; Martina Kinzig; Fritz Sörgel; W Weidner; Kurt G Naber
Concentrations in plasma, urinary excretion and bactericidal activity of levofloxacin (500 mg) versus ciprofloxacin (500 mg) in healthy volunteers receiving a single oral dose.
International journal of antimicrobial agents 2006;28(6):551-9.
2006: F M E Wagenlehner; Martina Kinzig; Uwe Tischmeyer; Christine Wagenlehner; Fritz Sörgel; Kurt G Naber
Urinary bactericidal activity of extended-release ciprofloxacin (1,000 milligrams) versus levofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.
Antimicrobial agents and chemotherapy 2006;50(11):3947-9.
2006: Uwe Fuhr; Melanie I Boettcher; Martina Kinzig; Alexandra Weyer; Alexander Jetter; Andreas Lazar; Dirk Taubert; Dorota Tomalik-Scharte; Panagiota Pournara; Verena Jakob; Steffi Harlfinger; Tobias Klaassen; Albrecht Berkessel; Jürgen Angerer; Fritz Sörgel; Edgar Schömig
Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(2):266-71.
2006: Fritz Sörgel; Jürgen Bulitta; Cornelia Landersdorfer
[What we know and what we want to know about beta-lactams. Pharmacokinetics and pharmacodynamics of beta lactams].
Pharmazie in unserer Zeit 2006;35(5):438-51.
2006: F M E Wagenlehner; Martina Kinzig; Uwe Tischmeyer; Christine Wagenlehner; Fritz Sörgel; Axel Dalhoff; Kurt G Naber
Pharmacokinetics of ciprofloxacin XR (1000 mg) versus levofloxacin (500 mg) in plasma and urine of male and female healthy volunteers receiving a single oral dose.
International journal of antimicrobial agents 2006;27(1):7-14.
2005: Dorota Tomalik-Scharte; Alexander Jetter; Martina Kinzig; Andreas Skott; Fritz Sörgel; Tobias Klaassen; Dirk Kasel; Steffi Harlfinger; Oxana Doroshyenko; D Frank; Julia Kirchheiner; M Bräter; K Richter; T Gramatté; Uwe Fuhr
Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1859-66.
2005: Alexander Jetter; Andreas Lazar; Edgar Schömig; Uwe Fuhr; Martina Kinzig; Fritz Sörgel
The CYP2C9 genotype does not influence sildenafil pharmacokinetics in healthy volunteers.
Clinical pharmacology and therapeutics 2005;78(4):441-3.
2005: F M E Wagenlehner; W Weidner; Fritz Sörgel; K G Naber
The role of antibiotics in chronic bacterial prostatitis.
International journal of antimicrobial agents 2005;26(1):1-7.
2005: Wolfgang A Krueger; Jürgen Bulitta; Martina Kinzig; Cornelia Landersdorfer; Ulrike Holzgrabe; Kurt G Naber; George L Drusano; Fritz Sörgel
Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.
Antimicrobial agents and chemotherapy 2005;49(5):1881-9.
2005: Martina Kinzig; Dorota Tomalik-Scharte; Alexander Jetter; Bernhard Scheidel; Verena Jakob; Michael Rodamer; Ingolf Cascorbi; Oxana Doroshyenko; Fritz Sörgel; Uwe Fuhr
Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses?
Antimicrobial agents and chemotherapy 2005;49(5):1733-8.
2005: Fritz Sörgel; Uwe Fuhr; M Minic; M Siegmund; J Maares; Alexander Jetter; Martina Kinzig; Dorota Tomalik-Scharte; J Szymanski; T Goeser; U Toex; B Scheidel; W Lehmacher
Pharmacokinetics of ibuprofen sodium dihydrate and gastrointestinal tolerability of short-term treatment with a novel, rapidly absorbed formulation.
International journal of clinical pharmacology and therapeutics 2005;43(3):140-9.
2004: Susanne Krege; Martina Kinzig; Fritz Sörgel; R Baschek; M C Michel; Herbert Rübben
Absorption of intravesically applied drugs: comparison of normal and ileal augmented rabbit bladder.
The Journal of urology 2004;172(5 Pt 1):2045-50.
2004: Alexander Jetter; Martina Kinzig; Andreas Skott; Andreas Lazar; Dorota Tomalik-Scharte; Julia Kirchheiner; Monika Walchner-Bonjean; Ursula Hering; Verena Jakob; Michael Rodamer; Wafaâ Jabrane; Dirk Kasel; Jürgen Brockmöller; Uwe Fuhr; Fritz Sörgel
Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.
European journal of clinical pharmacology 2004;60(3):165-71.
2004: Fritz Sörgel
The return of Ehrlich's 'Therapia magna sterilisans' and other Ehrlich concepts?. Series of papers honoring Paul Ehrlich on the occasion of his 150th birthday.
Chemotherapy 2004;50(1):6-10.
2004: Dieter Boy; Michaela Well; Martina Kinzig; Fritz Sörgel; Dorothe Ankel-Fuchs; Kurt G Naber
Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral dose.
International journal of antimicrobial agents 2004;23 Suppl 1():S6-16.
2004: Alexander Jetter; Martina Kinzig; Michael Illauer; Robert Hermann; Katharina Erb; Jürgen Borlak; Helga Wolf; Gillian Smith; Ingolf Cascorbi; Fritz Sörgel; Uwe Fuhr
Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.
European journal of clinical pharmacology 2004;60(1):17-21.
2004: Claudius Malerczyk; M Kolbert; Martina Kinzig; Fritz Sörgel; K Machka; P M Shah
Serum bactericidal activity of gemifloxacin versus clarithromycin against Streptococcus pneumoniae with different susceptibility to quinolones.
Journal of chemotherapy (Florence, Italy) 2004;16(1):56-61.
2004: Fritz Sörgel; Cornelia Landersdorfer; Jürgen Bulitta
[Two new antibiotics with special qualities: the pharmacokinetics of linezolid and telithromycin].
Pharmazie in unserer Zeit 2004;33(1):28-36.
2003: F M E Wagenlehner; Stephan Wydra; Hajime Onda; Martina Kinzig; Fritz Sörgel; Kurt G Naber
Concentrations in plasma, urinary excretion, and bactericidal activity of linezolid (600 milligrams) versus those of ciprofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.
Antimicrobial agents and chemotherapy 2003;47(12):3789-94.
2003: Kurt G Naber; Fritz Sörgel
Antibiotic therapy--rationale and evidence for optimal drug concentrations in prostatic and seminal fluid and in prostatic tissue.
Andrologia 2003;35(5):331-5.
2002: Friedrich Vogel; Horst Scholz; B al-Nawas; W Elies; M Kresken; Hartmut Lode; O Müller; K G Naber; E Petersen; P Shah; Fritz Sörgel; W Stille; C Tauchnitz; M Trautmann; U Ullmann; H Wacha; B Wiedemann
[Rational use of oral antibiotics. Findings of an expert commission of the Paul Ehrlich Society for Chemotherapy].
Medizinische Monatsschrift für Pharmazeuten 2002;25(6):193-204.
2002: Fritz Sörgel; Rainer Weissenbacher; Martina Kinzig; Annette Hofmann; Michael Illauer; Andreas Skott; Cornelia Landersdorfer
Acrylamide: increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans.
Chemotherapy 2002;48(6):267-74.
2002: Alexander Jetter; Martina Kinzig; Monika Walchner-Bonjean; Ursula Hering; Jürgen Bulitta; Philipp Schreiner; Fritz Sörgel; Uwe Fuhr
Effects of grapefruit juice on the pharmacokinetics of sildenafil.
Clinical pharmacology and therapeutics 2002;71(1):21-9.
2001: C K Naber; M Hammer; Martina Kinzig; C Sauber; Fritz Sörgel; E A Bygate; A J Fairless; K Machka; K G Naber
Urinary excretion and bactericidal activities of gemifloxacin and ofloxacin after a single oral dose in healthy volunteers.
Antimicrobial agents and chemotherapy 2001;45(12):3524-30.
2001: Irmgard Tegeder; Jörn Lötsch; Martina Kinzig; Fritz Sörgel; Gary R Kelm; S T Meller; Gerd Geisslinger
Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen.
Pharmaceutical research 2001;18(7):980-6.
2001: Fritz Sörgel; Jürgen Bulitta; Martina Kinzig
[How well do gyrase inhibitors work? The pharmacokinetics of quinolones].
Pharmazie in unserer Zeit 2001;30(5):418-27.
2001: C K Naber; M Steghafner; Martina Kinzig; C Sauber; Fritz Sörgel; H J Stahlberg; K G Naber
Concentrations of gatifloxacin in plasma and urine and penetration into prostatic and seminal fluid, ejaculate, and sperm cells after single oral administrations of 400 milligrams to volunteers.
Antimicrobial agents and chemotherapy 2001;45(1):293-7.
1999: Irmgard Tegeder; Uta Muth-Selbach; Jörn Lötsch; G Rüsing; R Oelkers; Kay Brune; S Meller; Gary R Kelm; Fritz Sörgel; Gerd Geisslinger
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration.
Clinical pharmacology and therapeutics 1999;65(4):357-68.
1999: Martina Kinzig; Uwe Fuhr; M Zaigler; J Dammeyer; G Rüsing; A Labedzki; Jürgen Bulitta; Fritz Sörgel
Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2.
Clinical pharmacology and therapeutics 1999;65(3):262-74.
1998: E Weidekamm; G Rüsing; H Caplain; Fritz Sörgel; C Crevoisier
Lack of bioequivalence of a generic mefloquine tablet with the standard product.
European journal of clinical pharmacology 1998;54(8):615-9.
1998: Roland Nau; Fritz Sörgel; Hilmar Prange
Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections.
Clinical pharmacokinetics 1998;35(3):223-46.
1998: Martina Kinzig; Uwe Fuhr; M Cesana; C Müller; A Horst Staib; Stephan Rietbrock; Fritz Sörgel
Absence of effect of rufloxacin on theophylline pharmacokinetics in steady state.
Antimicrobial agents and chemotherapy 1998;42(9):2359-64.
1998: Roland Nau; C Lassek; Martina Kinzig; A Thiel; Hilmar Prange; Fritz Sörgel
Disposition and elimination of meropenem in cerebrospinal fluid of hydrocephalic patients with external ventriculostomy.
Antimicrobial agents and chemotherapy 1998;42(8):2012-6.
1998: Kurt G Naber; U Theuretzbacher; Martina Kinzig; Orlin Savov; Fritz Sörgel
Urinary excretion and bactericidal activities of a single oral dose of 400 milligrams of fleroxacin versus a single oral dose of 800 milligrams of pefloxacin in healthy volunteers.
Antimicrobial agents and chemotherapy 1998;42(7):1659-65.
1998: M Engler; G Rüsing; Fritz Sörgel; Ulrike Holzgrabe
Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry.
Antimicrobial agents and chemotherapy 1998;42(5):1151-9.
1998: Michaela Well; Kurt G Naber; Martina Kinzig; Fritz Sörgel
Urinary bactericidal activity and pharmacokinetics of enoxacin versus norfloxacin and ciprofloxacin in healthy volunteers after a single oral dose.
International journal of antimicrobial agents 1998;10(1):31-8.
1997: Roland Nau; Martina Kinzig; Fritz Sörgel; S Schinschke; R Rössing; C Müller; Herbert Kolenda; Hilmar Prange
Kinetics of piperacillin and tazobactam in ventricular cerebrospinal fluid of hydrocephalic patients.
Antimicrobial agents and chemotherapy 1997;41(5):987-91.
1997: Thomas Foitzik; Hubert G Hotz; Martina Kinzig; Fritz Sörgel; Heinz J Buhr
Influence of changes in pancreatic tissue morphology and capillary blood flow on antibiotic tissue concentrations in the pancreas during the progression of acute pancreatitis.
Gut 1997;40(4):526-30.
1997: H Hofbauer; Kurt Naber; Martina Kinzig; Fritz Sörgel; C Rustige-Wiedemann; B Wiedemann; A Reiz; M Kresken
Urine bactericidal activity of pefloxacin versus norfloxacin in healthy female volunteers after a single 800-mg oral dose.
Infection 1997;25(2):121-6.
1996: Roland Nau; Hilmar Prange; Martina Kinzig; A Frank; A Dressel; P Scholz; Herbert Kolenda; Fritz Sörgel
Cerebrospinal fluid ceftazidime kinetics in patients with external ventriculostomies.
Antimicrobial agents and chemotherapy 1996;40(3):763-6.
1995: U Jaehde; Fritz Sörgel; A Reiter; G Sigl; K G Naber; W Schunack
Effect of probenecid on the distribution and elimination of ciprofloxacin in humans.
Clinical pharmacology and therapeutics 1995;58(5):532-41.
1995: U Jaehde; Fritz Sörgel; K G Naber; J Zürcher; W Schunack
Distribution kinetics of enoxacin and its metabolite oxoenoxacin in excretory fluids of healthy volunteers.
Antimicrobial agents and chemotherapy 1995;39(9):2092-7.
1994: Roland Nau; Martina Kinzig; T Dreyhaupt; Herbert Kolenda; Fritz Sörgel; Hilmar Prange
Kinetics of ofloxacin and its metabolites in cerebrospinal fluid after a single intravenous infusion of 400 milligrams of ofloxacin.
Antimicrobial agents and chemotherapy 1994;38(8):1849-53.
1994: U Jaehde; Fritz Sörgel; U Stephan; W Schunack
Effect of an antacid containing magnesium and aluminum on absorption, metabolism, and mechanism of renal elimination of pefloxacin in humans.
Antimicrobial agents and chemotherapy 1994;38(5):1129-33.
1994: Roland Nau; Fritz Sörgel; Hilmar Prange
Lipophilicity at pH 7.4 and molecular size govern the entry of the free serum fraction of drugs into the cerebrospinal fluid in humans with uninflamed meninges.
Journal of the neurological sciences 1994;122(1):61-5.
1994: Fritz Sörgel; Martina Kinzig
Pharmacokinetics and tissue penetration of piperacillin/tazobactam with particular reference to its potential in abdominal and soft tissue infections.
The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 1994;(573):39-44.
1993: K G Naber; Fritz Sörgel; Martina Kinzig; D M Weigel
Penetration of ciprofloxacin into prostatic fluid, ejaculate and seminal fluid in volunteers after an oral dose of 750 mg.
The Journal of urology 1993;150(5 Pt 2):1718-21.
1993: Roland Nau; Hilmar Prange; P Muth; Gerhard Mahr; S Menck; Herbert Kolenda; Fritz Sörgel
Passage of cefotaxime and ceftriaxone into cerebrospinal fluid of patients with uninflamed meninges.
Antimicrobial agents and chemotherapy 1993;37(7):1518-24.
1993: Fritz Sörgel; Martina Kinzig
Pharmacokinetics of gyrase inhibitors, Part 2: Renal and hepatic elimination pathways and drug interactions.
The American journal of medicine 1993;94(3A):56S-69S.
1993: Fritz Sörgel; Martina Kinzig
Pharmacokinetics of gyrase inhibitors, Part 1: Basic chemistry and gastrointestinal disposition.
The American journal of medicine 1993;94(3A):44S-55S.
1993: K G Naber; Martina Kinzig; Fritz Sörgel; D Weigel
Penetration of ofloxacin into prostatic fluid, ejaculate and seminal fluid.
Infection 1993;21(2):98-100.
1993: Uwe Fuhr; G Strobl; F Manaut; E M Anders; Fritz Sörgel; E Lopez-de-Brinas; Daniel T Chu; A G Pernet; Gerhard Mahr; F Sanz
Quinolone antibacterial agents: relationship between structure and in vitro inhibition of the human cytochrome P450 isoform CYP1A2.
Molecular pharmacology 1993;43(2):191-9.
1993: Fritz Sörgel; Martina Kinzig
The chemistry, pharmacokinetics and tissue distribution of piperacillin/tazobactam.
The Journal of antimicrobial chemotherapy 1993;31 Suppl A():39-60.
1992: Martina Kinzig; Fritz Sörgel; B Brismar; C E Nord
Pharmacokinetics and tissue penetration of tazobactam and piperacillin in patients undergoing colorectal surgery.
Antimicrobial agents and chemotherapy 1992;36(9):1997-2004.
1992: Uwe Fuhr; E M Anders; Gerhard Mahr; Fritz Sörgel; A Horst Staib
Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.
Antimicrobial agents and chemotherapy 1992;36(5):942-8.
1992: Gerhard Mahr; Fritz Sörgel; G Richard Granneman; Martina Kinzig; P Muth; K Patterson; Uwe Fuhr; P Nickel; U Stephan
Effects of temafloxacin and ciprofloxacin on the pharmacokinetics of caffeine.
Clinical pharmacokinetics 1992;22 Suppl 1():90-7.
1992: G Richard Granneman; U Stephan; B Birner; Fritz Sörgel; D Mukherjee
Effect of antacid medication on the pharmacokinetics of temafloxacin.
Clinical pharmacokinetics 1992;22 Suppl 1():83-9.
1992: Fritz Sörgel; G Richard Granneman; U Stephan; C Locke
Effect of cimetidine on the pharmacokinetics of temafloxacin.
Clinical pharmacokinetics 1992;22 Suppl 1():75-82.
1992: Fritz Sörgel; Gerhard Mahr; G Richard Granneman; U Stephan; P Nickel; P Muth
Effects of 2 quinolone antibacterials, temafloxacin and enoxacin, on theophylline pharmacokinetics.
Clinical pharmacokinetics 1992;22 Suppl 1():65-74.
1992: Fritz Sörgel
Penetration of temafloxacin into body tissues and fluids.
Clinical pharmacokinetics 1992;22 Suppl 1():57-63.
1992: Fritz Sörgel; G Richard Granneman; Gerhard Mahr; P Kujath; W Fabian; P Nickel
Hepatobiliary elimination of temafloxacin.
Clinical pharmacokinetics 1992;22 Suppl 1():33-42.
1992: G Richard Granneman; Gerhard Mahr; C Locke; P Nickel; W Kirch; W Fabian; Martina Kinzig; K G Naber; Fritz Sörgel
Pharmacokinetics of temafloxacin in patients with liver impairment.
Clinical pharmacokinetics 1992;22 Suppl 1():24-32.
1991: W P Gluth; Fritz Sörgel
Determination of oxprenolol and its glucuronide metabolite in plasma and urine using high-performance liquid chromatography.
Die Pharmazie 1991;46(5):336-9.
1991: K G Naber; Martina Kinzig; D Adam; Fritz Sörgel; A H Bajorski; R Kiehn
Concentrations of cefpodoxime in plasma, ejaculate and in prostatic fluid and adenoma tissue.
Infection 1991;19(1):30-5.
1990: J Mimeault; F Vallée; R Seelmann; Fritz Sörgel; M Ruel; M LeBel
Altered disposition of fleroxacin in patients with cystic fibrosis.
Clinical pharmacology and therapeutics 1990;47(5):618-28.
1989: Fritz Sörgel; K G Naber; U Jaehde; A Reiter; R Seelmann; G Sigl
Gastrointestinal secretion of ciprofloxacin. Evaluation of the charcoal model for investigations in healthy volunteers.
The American journal of medicine 1989;87(5A):62S-65S.
1989: K G Naber; Fritz Sörgel; Frieder Kees; U Jaehde; H Schumacher
Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration.
The American journal of medicine 1989;87(5A):57S-59S.
1989: Fritz Sörgel
Metabolism of gyrase inhibitors.
Reviews of infectious diseases 1989;11 Suppl 5():S1119-29.
1989: M Wenzel; Fritz Sörgel; P Muth; H Kraeft
[Enoxacin concentrations in serum and in the wall of the colon during colorectal surgery].
Infection 1989;17 Suppl 1():S27-9.
1989: D Adam; K Weismeier; Fritz Sörgel; J Zürcher
[Enoxacin concentration in bone tissue].
Infection 1989;17 Suppl 1():S25-6.
1989: D Adam; H Präuer; Fritz Sörgel; J Zürcher
[Enoxacin concentrations in lung tissue].
Infection 1989;17 Suppl 1():S21-2.
1989: Fritz Sörgel; U Jaehde; K Naber; U Stephan
Pharmacokinetic disposition of quinolones in human body fluids and tissues.
Clinical pharmacokinetics 1989;16 Suppl 1():5-24.
1989: K G Naber; Fritz Sörgel; Frieder Kees; H Schumacher; G Sigl; J Zürcher; S Berger
[Enoxacin concentration in seminal fluid, in prostate secretions and in prostatic adenoma tissue following oral administration or intravenous infusion].
Infection 1989;17 Suppl 1():S30-6.
1988: Fritz Sörgel; R Seelmann; K Naber; R Metz; P Muth
Metabolism of fleroxacin in man.
The Journal of antimicrobial chemotherapy 1988;22 Suppl D():169-78.
1988: K G Naber; Fritz Sörgel; Frieder Kees; H Schumacher; R Metz; H Grobecker
In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue.
The Journal of antimicrobial chemotherapy 1988;22 Suppl D():199-207.
1988: B Gottschalk; Fritz Sörgel; HG Wiesemann; U Stephan; M Rey; H B Böwing; C Stehr; H C Dominick; D Kiosz; M Geldmacher-von Mallinckrodt
[Antibiotic pharmacokinetics in patients with mucoviscidosis].
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde 1988;136(8):475-8.
1988: W P Gluth; Fritz Sörgel; B Gluth; J Braun; M Geldmacher-von Mallinckrodt
Determination of sotalol in human body fluids for pharmacokinetic and toxicokinetic studies using high-performance liquid chromatography.
Arzneimittel-Forschung 1988;38(3):408-11.
1988: J Braun; Fritz Sörgel; W P Gluth; S Oie
Does alpha 1-acid glycoprotein reduce the unbound metabolic clearance of disopyramide in patients with renal impairment?
European journal of clinical pharmacology 1988;35(3):313-7.
1987: J Braun; Fritz Sörgel; W P Gluth; S Oie
Bioavailability of disopyramide in normal volunteers using unbound concentration.
European journal of clinical pharmacology 1987;32(6):625-9.
1987: Fritz Sörgel; U Stephan; HG Wiesemann; B Gottschalk; C Stehr; M Rey; H B Böwing; H C Dominick; M Geldmacher von Mallinckrodt
High dose treatment with antibiotics in cystic fibrosis--a reappraisal with special reference to the pharmacokinetics of beta-lactams and new fluoroquinolones in adult CF-patients.
Infection 1987;15(5):385-96.
1985: J Braun; Fritz Sörgel; F Engelmaier; W P Gluth; U Gessler
Pharmacokinetics of tocainide in patients with severe renal failure.
European journal of clinical pharmacology 1985;28(6):665-70.