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Alexander Sorkin

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Tatiana Sorkina; John Caltagarone; Alexander Sorkin
Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis.
Sarah M Rogstad; Alexander Sorkin; Tatiana Sorkina; Christine C Wu
Improved precision of proteomic measurements in immunoprecipitation based purifications using relative quantitation.
Anjali Rao; Diana Simmons; Alexander Sorkin
Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.

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All Publications

2013: Tatiana Sorkina; John Caltagarone; Alexander Sorkin
Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis.
Traffic (Copenhagen, Denmark) 2013;14(6):709-24.
2013: Sarah M Rogstad; Alexander Sorkin; Tatiana Sorkina; Christine C Wu
Improved precision of proteomic measurements in immunoprecipitation based purifications using relative quantitation.
Analytical chemistry 2013;85(9):4301-6.
2011: Anjali Rao; Diana Simmons; Alexander Sorkin
Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.
Molecular and cellular neurosciences 2011;46(1):148-58.
2010: Jason E Duex; Michael R Mullins; Alexander Sorkin
Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking.
Experimental cell research 2010;316(13):2136-51.
2010: Lai Kuan Goh; Fangtian Huang; Woong Kim; Steven Gygi; Alexander Sorkin
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor.
The Journal of cell biology 2010;189(5):871-83.
2010: Arnau Vina-Vilaseca; Alexander Sorkin
Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.
The Journal of biological chemistry 2010;285(10):7645-56.
2010: Alexander Sorkin; Jason E Duex
Quantitative analysis of endocytosis and turnover of epidermal growth factor (EGF) and EGF receptor.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2010;Chapter 15():Unit 15.14.
2009: David A Price; Alexander Sorkin; Nancy R Zahniser
Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.
Molecular pharmacology 2009;76(4):812-23.
2009: Alexander Sorkin; Mark von Zastrow
Endocytosis and signalling: intertwining molecular networks.
Nature reviews. Molecular cell biology 2009;10(9):609-22.
2009: Nancy R Zahniser; Alexander Sorkin
Trafficking of dopamine transporters in psychostimulant actions.
Seminars in cell & developmental biology 2009;20(4):411-7.
2009: Jason E Duex; Alexander Sorkin
RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis.
Molecular biology of the cell 2009;20(6):1833-44.
2009: Alexander Sorkin; Lai Kuan Goh
Endocytosis and intracellular trafficking of ErbBs.
Experimental cell research 2009;315(4):683-96.
2009: Tatiana Sorkina; Toni L Richards; Anjali Rao; Nancy R Zahniser; Alexander Sorkin
Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(5):1361-74.
2008: Alexander Sorkin; Lai Kuan Goh
Endocytosis and intracellular trafficking of ErbBs.
Experimental cell research 2008;314(17):3093-106.
2008: Emilia Galperin; Alexander Sorkin
Endosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin-dependent endocytosis.
Traffic (Copenhagen, Denmark) 2008;9(10):1776-90.
2007: Fangtian Huang; Lai Kuan Goh; Alexander Sorkin
EGF receptor ubiquitination is not necessary for its internalization.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16904-9.
2007: Mark von Zastrow; Alexander Sorkin
Signaling on the endocytic pathway.
Current opinion in cell biology 2007;19(4):436-45.
2007: Alexander Sorkin
Ubiquitination without E3.
Molecular cell 2007;26(6):771-3.
2007: Manuel Miranda; Alexander Sorkin
Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms.
Molecular interventions 2007;7(3):157-67.
2007: Brian R Hoover; C V Everett; Alexander Sorkin; Nancy R Zahniser
Rapid regulation of dopamine transporters by tyrosine kinases in rat neuronal preparations.
Journal of neurochemistry 2007;101(5):1258-71.
2007: Manuel Miranda; Kalen R Dionne; Tatiana Sorkina; Alexander Sorkin
Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter.
Molecular biology of the cell 2007;18(1):313-23.
2006: Tatiana Sorkina; Manuel Miranda; Kalen R Dionne; Brian R Hoover; Nancy R Zahniser; Alexander Sorkin
RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(31):8195-205.
2006: Fangtian Huang; Donald Kirkpatrick; Xuejun Jiang; Steven Gygi; Alexander Sorkin
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
Molecular cell 2006;21(6):737-48.
2005: Manuel Miranda; Christine C Wu; Tatiana Sorkina; Davin R Korstjens; Alexander Sorkin
Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C.
The Journal of biological chemistry 2005;280(42):35617-24.
2005: Vladislav Verkhusha; Alexander Sorkin
Conversion of the monomeric red fluorescent protein into a photoactivatable probe.
Chemistry & biology 2005;12(3):279-85.
2005: Fangtian Huang; Alexander Sorkin
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.
Molecular biology of the cell 2005;16(3):1268-81.
2005: Tatiana Sorkina; Brian R Hoover; Nancy R Zahniser; Alexander Sorkin
Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism.
Traffic (Copenhagen, Denmark) 2005;6(2):157-70.
2005: Alexander Sorkin
TRKing signals through the Golgi.
Science's STKE : signal transduction knowledge environment 2005;2005(267):pe1.
2005: Emilia Galperin; Alexander Sorkin
Visualization of Rab5 activity in living cells using FRET microscopy.
Methods in enzymology 2005;403():119-34.
2004: Emilia Galperin; Vladislav Verkhusha; Alexander Sorkin
Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells.
Nature methods 2004;1(3):209-17.
2004: Lene Melsaether Grøvdal; espen stang; Alexander Sorkin; Inger Helene Madshus
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.
Experimental cell research 2004;300(2):388-95.
2004: Anna Lladó; Francesc Tebar; María Calvo; Jemina Moretó; Alexander Sorkin; Carlos Enrich
Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes.
Molecular biology of the cell 2004;15(11):4877-91.
2004: Alexander Sorkin
Cargo recognition during clathrin-mediated endocytosis: a team effort.
Current opinion in cell biology 2004;16(4):392-9.
2004: Manuel Miranda; Tatiana Sorkina; Tom N Grammatopoulos; W Michael Zawada; Alexander Sorkin
Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum.
The Journal of biological chemistry 2004;279(29):30760-70.
2004: Fangtian Huang; Anastasia Khvorova; William Marshall; Alexander Sorkin
Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.
The Journal of biological chemistry 2004;279(16):16657-61.
2004: Nancy R Zahniser; Alexander Sorkin
Rapid regulation of the dopamine transporter: role in stimulant addiction?
Neuropharmacology 2004;47 Suppl 1():80-91.
2003: Emilia Galperin; Alexander Sorkin
Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis.
Journal of cell science 2003;116(Pt 23):4799-810.
2003: Fangtian Huang; Xuejun Jiang; Alexander Sorkin
Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking.
The Journal of biological chemistry 2003;278(44):43411-7.
2003: Xuejun Jiang; Alexander Sorkin
Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation.
Traffic (Copenhagen, Denmark) 2003;4(8):529-43.
2003: Tatiana Sorkina; Suzanne Doolen; Emilia Galperin; Nancy R Zahniser; Alexander Sorkin
Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy.
The Journal of biological chemistry 2003;278(30):28274-83.
2003: Xuejun Jiang; Fangtian Huang; Andriy Marusyk; Alexander Sorkin
Grb2 regulates internalization of EGF receptors through clathrin-coated pits.
Molecular biology of the cell 2003;14(3):858-70.
2002: Alexander Sorkin; Mark von Zastrow
Signal transduction and endocytosis: close encounters of many kinds.
Nature reviews. Molecular cell biology 2002;3(8):600-14.
2002: Tatiana Sorkina; Fangtian Huang; Laura Beguinot; Alexander Sorkin
Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor.
The Journal of biological chemistry 2002;277(30):27433-41.
2002: Francesc Tebar; villalonga priam; Tatiana Sorkina; Neus Agell; Alexander Sorkin; Carlos Enrich
Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway.
Molecular biology of the cell 2002;13(6):2057-68.
2002: Xuejun Jiang; Alexander Sorkin
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells.
Molecular biology of the cell 2002;13(5):1522-35.
2002: Sandra L Schmid; Alexander Sorkin
Days and knights discussing membrane dynamics in endocytosis: meeting report from the Euresco/EMBL Membrane Dynamics in Endocytosis, 6--11 October in Tomar, Portugal.
Traffic (Copenhagen, Denmark) 2002;3(1):77-85.
2001: Alexander Sorkin
Internalization of the epidermal growth factor receptor: role in signalling.
Biochemical Society transactions 2001;29(Pt 4):480-4.
2001: F Huang; A Nesterov; RE Carter; Alexander Sorkin
Trafficking of yellow-fluorescent-protein-tagged mu1 subunit of clathrin adaptor AP-1 complex in living cells.
Traffic (Copenhagen, Denmark) 2001;2(5):345-57.
2001: C Gu; Alexander Sorkin; D M Cooper
Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase.
Current biology : CB 2001;11(3):185-90.
2000: Alexander Sorkin
The endocytosis machinery.
Journal of cell science 2000;113 Pt 24():4375-6.
2000: Alexander Sorkin; M McClure; Fangtian Huang; R Carter
Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy.
Current biology : CB 2000;10(21):1395-8.
2000: V Jullien-Flores; Y Mahé; Gladys Mirey; corinne leprince; B Meunier-Bisceuil; Alexander Sorkin; Jacques Camonis
RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.
Journal of cell science 2000;113 ( Pt 16)():2837-44.
1999: Francesc Tebar; S K Bohlander; Alexander Sorkin
Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.
Molecular biology of the cell 1999;10(8):2687-702.
1999: A Nesterov; RE Carter; Tatiana Sorkina; Gordon N Gill; Alexander Sorkin
Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.
The EMBO journal 1999;18(9):2489-99.
1999: Tatiana Sorkina; Andrea Bild; Francesc Tebar; Alexander Sorkin
Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors.
Journal of cell science 1999;112 ( Pt 3)():317-27.
1998: RE Carter; Alexander Sorkin
Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera.
The Journal of biological chemistry 1998;273(52):35000-7.
1998: Tonny de Beer; RE Carter; K E Lobel-Rice; Alexander Sorkin; Michael Overduin
Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
Science (New York, N.Y.) 1998;281(5381):1357-60.
1998: Laura Coda; Anna Elisabetta Salcini; Stefano Confalonieri; Giuliana Pelicci; Tatiana Sorkina; Alexander Sorkin; Pier Giuseppe Pelicci; Pier Paolo Di Fiore
Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization.
The Journal of biological chemistry 1998;273(5):3003-12.
1997: Pier Paolo Di Fiore; P G Pelicci; Alexander Sorkin
EH: a novel protein-protein interaction domain potentially involved in intracellular sorting.
Trends in biochemical sciences 1997;22(11):411-3.
1997: Francesc Tebar; Stefano Confalonieri; RE Carter; Pier Paolo Di Fiore; Alexander Sorkin
Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region.
The Journal of biological chemistry 1997;272(24):15413-8.
1996: E Kornilova; Tatiana Sorkina; L Beguinot; Alexander Sorkin
Lysosomal targeting of epidermal growth factor receptors via a kinase-dependent pathway is mediated by the receptor carboxyl-terminal residues 1022-1123.
The Journal of biological chemistry 1996;271(48):30340-6.
1996: Francesc Tebar; Tatiana Sorkina; Alexander Sorkin; M Ericsson; Tomas Kirchhausen
Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits.
The Journal of biological chemistry 1996;271(46):28727-30.
1996: Alexander Sorkin; M Mazzotti; Tatiana Sorkina; L Scotto; L Beguinot
Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif.
The Journal of biological chemistry 1996;271(23):13377-84.
1995: Graham Carpenter; C Soler; J Baulida; L Beguinot; Alexander Sorkin
Interaction of signaling and trafficking proteins with the carboxyterminus of the epidermal growth factor receptor.
Annals of the New York Academy of Sciences 1995;766():44-51.
1995: Alexander Sorkin; TA McKinsey; W Shih; Tomas Kirchhausen; Graham Carpenter
Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2.
The Journal of biological chemistry 1995;270(2):619-25.
1993: Alexander Sorkin; Pier Paolo Di Fiore; Graham Carpenter
The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired.
Oncogene 1993;8(11):3021-8.
1993: C Soler; L Beguinot; Alexander Sorkin; Graham Carpenter
Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal growth factor receptor.
The Journal of biological chemistry 1993;268(29):22010-9.
1993: Alexander Sorkin; A Eriksson; C H Heldin; B Westermark; L Claesson-Welsh
Pool of ligand-bound platelet-derived growth factor beta-receptors remain activated and tyrosine phosphorylated after internalization.
Journal of cellular physiology 1993;156(2):373-82.
1993: Alexander Sorkin; Graham Carpenter
Interaction of activated EGF receptors with coated pit adaptins.
Science (New York, N.Y.) 1993;261(5121):612-5.
1993: Alexander Sorkin; C M Waters
Endocytosis of growth factor receptors.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(6):375-82.
1992: C M Waters; K A Overholser; Alexander Sorkin; Graham Carpenter
Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism.
Journal of cellular physiology 1992;152(2):253-63.
1992: Alexander Sorkin; K Helin; C M Waters; Graham Carpenter; L Beguinot
Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.
The Journal of biological chemistry 1992;267(12):8672-8.
1992: M Iu D'iakonova; Alexander Sorkin; N N Nikol'skiĭ
[The effect of the lysosomotropic agent primaquine on the endocytosis of the epidermal growth factor receptors in A431 cells].
Tsitologiia 1992;34(7):63-9.
1992: M Iu D'iakonova; Alexander Sorkin; N N Nikol'skiĭ
[The characteristics of the internalization of normal and mutant receptors for the growth factor released by thrombocytes].
Tsitologiia 1992;34(8):74-81.
1991: Alexander Sorkin; Graham Carpenter
Dimerization of internalized epidermal growth factor receptors.
The Journal of biological chemistry 1991;266(34):23453-60.
1991: Alexander Sorkin; C Waters; K A Overholser; Graham Carpenter
Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis.
The Journal of biological chemistry 1991;266(13):8355-62.
1991: Alexander Sorkin; Bengt Westermark; Carl-Henrik Heldin; Lena Claesson-Welsh
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.
The Journal of cell biology 1991;112(3):469-78.
1991: Alexander Sorkin; S Krolenko; N Kudrjavtceva; J Lazebnik; LV Teslenko; A M Soderquist; N Nikolsky
Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways.
The Journal of cell biology 1991;112(1):55-63.
1990: N A Vinogradova; A M Nesterov; G F Reshetnikova; Alexander Sorkin; N N Nikol'skiĭ
[The immunofluorescent detection of phosphorylated receptors of the epidermal growth factor during their internalization in A-431 cells].
Tsitologiia 1990;32(4):384-7.
1989: I A Khrebtukova; A N Nikol'skaia; Alexander Sorkin; A B Sorokin; G P Pinaev
[The capping of receptors for the epidermal growth factor and the participation of the cytoskeleton in this process in A-431 cells].
Tsitologiia 1989;31(10):1211-20.
1989: A B Sorokin; A M Nesterov; Alexander Sorkin; T N Ignatova; K I Galaktionov
[Isolation and characteristics of monoclonal antibodies to the external domain of the EGF receptor in human A431 epidermoid carcinoma].
Tsitologiia 1989;31(5):549-55.
1989: Alexander Sorkin; E Kornilova; LV Teslenko; A Sorokin; N Nikolsky
Recycling of epidermal growth factor-receptor complexes in A431 cells.
Biochimica et biophysica acta 1989;1011(1):88-96.
1989: Alexander Sorkin; N P Bogdanova; A B Sorokin; LV Teslenko; N N Nikol'skiĭ
[The recycling of EGF-receptor complexes in A431 cells].
Tsitologiia 1989;31(3):300-11.
1988: R S Barkan; Alexander Sorkin; N N Nikol'skiĭ
[Endocytosis and intracellular transport of epidermal growth factor after destruction of the actin cytoskeleton by cytochalasin B].
Tsitologiia 1988;30(11):1311-7.
1988: Alexander Sorkin; LV Teslenko; N N Nikolsky
The endocytosis of epidermal growth factor in A431 cells: a pH of microenvironment and the dynamics of receptor complex dissociation.
Experimental cell research 1988;175(1):192-205.
1987: A M Nesterov; N A Vinogradova; N V Kudriavtseva; Alexander Sorkin; A B Sorokin
[Effect of dansylcadaverine on the epidermal growth factor-stimulated phosphorylation of uridine].
Tsitologiia 1987;29(9):1020-6.
1987: LV Teslenko; Elena S Kornilova; Alexander Sorkin; N N Nikolsky
Recycling of epidermal growth factor in A431 cells.
FEBS letters 1987;221(1):105-9.
1987: Elena S Kornilova; Alexander Sorkin; N N Nikol'skiĭ
[Compartmentalization dynamics of the epidermal growth factor in A431 cells].
Tsitologiia 1987;29(8):904-10.
1986: E V Leonova; Alexander Sorkin; LV Teslenko; VI Rodionov; E S Nadezhdina
[A cytoskeletal protein with a molecular weight of 100 kD is a component of the endosomes participating in receptor-mediated endocytosis].
Tsitologiia 1986;28(11):1222-6.
1986: LV Teslenko; O F Zvonarev; S A Plakhov; Alexander Sorkin; N N Nikol'skiĭ
[Receptor-mediated endocytosis of alpha 2-macroglobulin in living intact 3T3 cells].
Tsitologiia 1986;28(10):1097-102.
1986: Alexander Sorkin; LV Teslenko; N N Nikol'skiĭ; A S Troshin
[Common endocytosis pathway of the epidermal growth factor and transferrin associated with the Golgi apparatus acidic (ph 6.1) compartment of A431 cells].
Doklady Akademii nauk SSSR 1986;289(1):212-5.
1985: N N Nikol'skiĭ; N P Bogdanova; N A Vinogradova; A M Nesterov; Alexander Sorkin
[Stimulating action of epidermal growth factor and insulin on uridine phosphorylation in 3T3 and 3T6 cells].
Tsitologiia 1985;27(12):1367-73.
1985: Alexander Sorkin; N P Bogdanova; N N Nikol'skiĭ; A B Sorokin
[Effect of amines on the pH in the lysosomes of 3T3 cells].
Tsitologiia 1985;27(2):203-8.
1984: K V Sal'nikov; Alexander Sorkin
[Decreased rate of uridine and glycerin uptake in L cells resistant to ethidium bromide].
Tsitologiia 1984;26(6):699-705.
1983: Alexander Sorkin; A B Sorokin
[Mathematical analysis and experimental study of uridine transport and phosphorylation in 3T6 cells].
Tsitologiia 1983;25(7):784-92.
1981: A B Sorokin; Alexander Sorkin; N N Nikol'skiĭ
[Uridine transport and phosphorylation in 3T3 and CHO cells with induced cell proliferation].
Tsitologiia 1981;23(5):523-30.
1981: A B Sorokin; Alexander Sorkin; N N Nikol'skiĭ
[Uridine transport and phosphorylation in 3T3 and CHO cells depending on the culture growth conditions].
Tsitologiia 1981;23(4):419-26.