Timo Sorsa

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Rahkonen Leena; Rutanen Eeva-Marja; Unkila-Kallio Leila; Nuutila Mika; Nieminen Pekka; Sorsa Timo; Paavonen Jorma
Factors affecting matrix metalloproteinase-8 levels in the vaginal and cervical fluids in the first and second trimester of pregnancy.
Biyikoglu Basak; Buduneli Nurcan; Kardesler Levent; Aksu Kenan; Pitkala Marjut; Sorsa Timo
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Gürsoy M; Haraldsson G; Hyvönen M; Sorsa T; Pajukanta R; Könönen E
Does the frequency of Prevotella intermedia increase during pregnancy?

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2009: Rahkonen Leena; Rutanen Eeva-Marja; Unkila-Kallio Leila; Nuutila Mika; Nieminen Pekka; Sorsa Timo; Paavonen Jorma
Factors affecting matrix metalloproteinase-8 levels in the vaginal and cervical fluids in the first and second trimester of pregnancy.
Human reproduction (Oxford, England) 2009;24(11):2693-702.
2009: Biyikoglu Basak; Buduneli Nurcan; Kardesler Levent; Aksu Kenan; Pitkala Marjut; Sorsa Timo
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Journal of periodontology 2009;80(8):1307-14.
2009: Gürsoy M; Haraldsson G; Hyvönen M; Sorsa T; Pajukanta R; Könönen E
Does the frequency of Prevotella intermedia increase during pregnancy?
Oral microbiology and immunology 2009;24(4):299-303.
2009: Korpi Jarkko T; Aström Pirjo; Lehtonen Niko; Tjäderhane Leo; Kallio-Pulkkinen Soili; Siponen Maria; Sorsa Timo; Pirilä Emma; Salo Tuula
Healing of extraction sockets in collagenase-2 (matrix metalloproteinase-8)-deficient mice.
European journal of oral sciences 2009;117(3):248-54.
2009: Pirhan Demet; Atilla Gül; Emingil Gülnur; Tervahartiala Taina; Sorsa Timo; Berdeli Afig
MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy.
Journal of clinical periodontology 2009;36(6):474-81.
2009: Suojanen J; Sorsa T; Salo T
Tranexamic acid can inhibit tongue squamous cell carcinoma invasion in vitro.
Oral diseases 2009;15(2):170-5.
2009: Beklen A; Sorsa T; Konttinen Y T
Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17.
Oral microbiology and immunology 2009;24(1):38-42.
2009: Kuula Heidi; Salo Tuula; Pirilä Emma; Tuomainen Anita M; Jauhiainen Matti; Uitto Veli-Jukka; Tjäderhane Leo; Pussinen Pirkko J; Sorsa Timo
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.
Infection and immunity 2009;77(2):850-9.
2008: Emingil Gülnur; Afacan Beral; Tervahartiala Taina; Töz Hüseyin; Atilla Gül; Sorsa Timo
By mistakes we learn: determination of matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 in serum yields doubtful results.
Journal of clinical periodontology 2008;35(12):1087-8.
2008: Heikkinen Anna Maria; Pajukanta Riitta; Pitkäniemi Janne; Broms Ulla; Sorsa Timo; Koskenvuo Markku; Meurman Jukka H
The effect of smoking on periodontal health of 15- to 16-year-old adolescents.
Journal of periodontology 2008;79(11):2042-7.
2008: Vardar-Sengul Saynur; Buduneli Eralp; Turkoglu Oya; Buduneli Nurcan; Atilla Gül; Wahlgren Jaana; Sorsa Timo; Baylas Haluk
The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis.
Journal of periodontology 2008;79(10):1934-41.
2008: Pirhan Demet; Atilla Gül; Emingil Gülnur; Sorsa Timo; Tervahartiala Taina; Berdeli Afig
Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis.
Journal of clinical periodontology 2008;35(10):862-70.
2008: Golub Lorne M; Lee Hsi Ming; Stoner Julie A; Sorsa Timo; Reinhardt Richard A; Wolff Mark S; Ryan Maria E; Nummikoski Pirkka V; Payne Jeffrey B
Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.
Journal of periodontology 2008;79(8):1409-18.
2008: Vihinen Pia; Koskivuo Ilkka; Syrjänen Kari; Tervahartiala Taina; Sorsa Timo; Pyrhönen Seppo
Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.
Melanoma research 2008;18(4):268-73.
2008: Xu Ling; Yu Zhao; Lee Hsi-Ming; Wolff Mark S; Golub Lorne M; Sorsa Timo; Kuula Heidi
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Acta odontologica Scandinavica 2008;66(4):219-24.
2008: Laaksonen Matti; Suojanen Juho; Nurmenniemi Sini; Läärä Esa; Sorsa Timo; Salo Tuula
The enamel matrix derivative (Emdogain) enhances human tongue carcinoma cells gelatinase production, migration and metastasis formation.
Oral oncology 2008;44(8):733-42.
2008: Gürsoy Mervi; Pajukanta Riitta; Sorsa Timo; Könönen Eija
Clinical changes in periodontium during pregnancy and post-partum.
Journal of clinical periodontology 2008;35(7):576-83.
2008: Pärnänen P; Kari K; Virtanen I; Sorsa T; Meurman J H
Human laminin-332 degradation by Candida proteinases.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2008;37(6):329-35.
2008: Määttä Marko; Kari Osmo; Tervahartiala Taina; Wahlgren Jaana; Peltonen Sirje; Kari Marjatta; Rytilä Paula; Saari Matti; Sorsa Timo
Elevated expression and activation of matrix metalloproteinase 8 in tear fluid in atopic blepharoconjunctivitis.
Cornea 2008;27(3):297-301.
2008: Emingil Gülnur; Atilla Gül; Sorsa Timo; Tervahartiala Taina
The effect of adjunctive subantimicrobial dose doxycycline therapy on GCF EMMPRIN levels in chronic periodontitis.
Journal of periodontology 2008;79(3):469-76.
2008: Emingil Gülnur; Afacan Beral; Tervahartiala Taina; Töz Hüseyin; Atilla Gül; Sorsa Timo
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy.
Journal of clinical periodontology 2008;35(3):221-9.
2008: Avellán Nina-Li; Sorsa Timo; Tervahartiala Taina; Forster Clemens; Kemppainen Pentti
Experimental tooth pain elevates substance P and matrix metalloproteinase-8 levels in human gingival crevice fluid.
Acta odontologica Scandinavica 2008;66(1):18-22.
2008: Korpi J T; Kervinen V; Mäklin H; Väänänen A; Lahtinen M; Läärä E; Ristimäki A; Thomas G; Ylipalosaari M; Aström P; Lopez-Otin C; Sorsa T; Kantola S; Pirilä E; Salo T
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
British journal of cancer 2008;98(4):766-75.
2008: Kostamo Katriina; Toskala Elina; Tervahartiala Taina; Sorsa Timo
Role of matrix metalloproteinases in chronic rhinosinusitis.
Current opinion in allergy and clinical immunology 2008;8(1):21-7.
2008: Vilen Suvi-Tuuli; Nyberg Pia; Hukkanen Mika; Sutinen Meeri; Ylipalosaari Merja; Bjartell Anders; Paju Annukka; Haaparanta Virpi; Stenman Ulf-Håkan; Sorsa Timo; Salo Tuula
Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma.
Experimental cell research 2008;314(4):914-26.
2008: Kuula Heidi; Salo Tuula; Pirilä Emma; Hagström Jaana; Luomanen Marita; Gutierrez-Fernandez Ana; Romanos Georgios E; Sorsa Timo
Human beta-defensin-1 and -2 and matrix metalloproteinase-25 and -26 expression in chronic and aggressive periodontitis and in peri-implantitis.
Archives of oral biology 2008;53(2):175-86.
2008: Lauhio Anneli; Sorsa Timo; Srinivas Ravi; Stenman Mathias; Tervahartiala Taina; Stenman Ulf-Håkan; Grönhagen-Riska Carola; Honkanen Eero
Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy.
Annals of medicine 2008;40(4):312-20.
2007: Leskinen Markus J; Eklund Kari K; Sorsa Timo; Golub Lorne M; Kovanen Petri T; Lindstedt Ken A
Inhibition of smooth muscle cell proliferation by a chemically modified tetracycline.
Coronary artery disease 2007;18(8):663-7.
2007: Tuomainen Anita M; Nyyssönen Kristiina; Laukkanen Jari A; Tervahartiala Taina; Tuomainen Tomi-Pekka; Salonen Jukka T; Sorsa Timo; Pussinen Pirkko J
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(12):2722-8.
2007: Suojanen Juho; Salo Tuula; Sorsa Timo; Koivunen Erkki
AlphaMbeta2 integrin modulator exerts antitumor activity in vivo.
Anticancer research 2007;27(6B):3775-81.
2007: Asikainen A J; Hagström J; Sorsa T; Noponen J; Kellomäki M; Juuti H; Lindqvist C; Hietanen J; Suuronen R
Soft tissue reactions to bioactive glass 13-93 combined with chitosan.
Journal of biomedical materials research. Part A 2007;83(2):530-7.
2007: Stamatova Iva; Meurman Jukka H; Kari Kirsti; Tervahartiala Taina; Sorsa Timo; Baltadjieva Maria
Safety issues of Lactobacillus bulgaricus with respect to human gelatinases in vitro.
FEMS immunology and medical microbiology 2007;51(1):194-200.
2007: Reinhardt Richard A; Stoner Julie A; Golub Lorne M; Wolff Mark S; Lee Hsi-Ming; Meinberg Trudy A; Lynch James C; Ryan Maria E; Sorsa Timo; Payne Jeffrey B
Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women: clinical outcomes.
Journal of clinical periodontology 2007;34(9):768-75.
2007: Kostamo Katriina; Tervahartiala Taina; Sorsa Timo; Richardson Malcolm; Toskala Elina
Metalloproteinase function in chronic rhinosinusitis with nasal polyposis.
The Laryngoscope 2007;117(4):638-43.
2007: Beklen A; Ainola M; Hukkanen M; Gürgan C; Sorsa T; Konttinen Y T
MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis.
Journal of dental research 2007;86(4):347-51.
2007: Hästbacka Johanna; Hynninen Marja; Kolho Elina; Pettilä Ville; Tervahartiala Taina; Sorsa Timo; Lauhio Anneli
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis.
Shock (Augusta, Ga.) 2007;27(2):145-50.
2007: Sulkala Merja; Tervahartiala Taina; Sorsa Timo; Larmas Markku; Salo Tuula; Tjäderhane Leo
Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin.
Archives of oral biology 2007;52(2):121-7.
2007: Pirilä Emma; Korpi Jarkko T; Korkiamäki Timo; Jahkola Tiina; Gutierrez-Fernandez Ana; Lopez-Otin Carlos; Saarialho-Kere Ulpu; Salo Tuula; Sorsa Timo
Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007;15(1):47-57.
2007: Buduneli Eralp; Vardar-Sengül Saynur; Buduneli Nurcan; Atilla Gül; Wahlgren Jaana; Sorsa Timo
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate.
Journal of periodontology 2007;78(1):127-34.
2007: Ilumets Helen; Rytilä Paula; Demedts Ingel; Brusselle Guy G; Sovijärvi Anssi; Myllärniemi Marjukka; Sorsa Timo; Kinnula Vuokko L
Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD.
International journal of chronic obstructive pulmonary disease 2007;2(3):369-79.
2007: Pussinen Pirkko J; Paju Susanna; Mäntylä Päivi; Sorsa Timo
Serum microbial- and host-derived markers of periodontal diseases: a review.
Current medicinal chemistry 2007;14(22):2402-12.
2007: Sorsa Timo; Meurman Jukka H
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(1):7-9.
2006: Emingil Gülnur; Tervahartiala Taina; Mãntylã Pãivi; Määttä Marko; Sorsa Timo; Atilla Gül
Gingival crevicular fluid matrix metalloproteinase (MMP)-7, extracellular MMP inducer, and tissue inhibitor of MMP-1 levels in periodontal disease.
Journal of periodontology 2006;77(12):2040-50.
2006: Mäntylä P; Stenman M; Kinane D; Salo T; Suomalainen K; Tikanoja S; Sorsa T
Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test.
Journal of periodontal research 2006;41(6):503-12.
2006: Määttä Marko; Tervahartiala Taina; Kaarniranta Kai; Tang Yi; Yan Li; Tuukkanen Juha; Sorsa Timo
Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids.
Current eye research 2006;31(11):917-24.
2006: Ilgenli T; Vardar-Sengul S; Gürkan A; Sorsa T; Stackelberg S; Köse T; Atilla G
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases.
Oral diseases 2006;12(6):573-9.
2006: Salo Tuula; Sorsa Timo; Lindqvist Christian
Inhibition of gelatinase activity by cyclic peptides--A support for oral cancer treatment?
Oral oncology 2006;42(10):955-6.
2006: Rajamäki Minna M; Sorsa Timo
Osteoarthritis: linking nitric oxide and metalloproteinases in canine articular ligament pathology.
Veterinary journal (London, England : 1997) 2006;172(3):400-1.
2006: Mellanen Liisa; Lähdevirta Juhani; Tervahartiala Taina; Meurman Jukka H; Sorsa Timo
Matrix metalloproteinase-7, -8, -9, -25, and -26 and CD43, -45, and -68 cell-markers in HIV-infected patients' saliva and gingival tissue.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2006;35(9):530-9.
2006: Furuholm J; Sorsa T; Qvarnström M; Janket S-J; Tervahartiala T; Nuutinen P; Meurman J H
Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease.
Journal of periodontal research 2006;41(5):486-9.
2006: Cederqvist Katariina; Janer Joakim; Tervahartiala Taina; Sorsa Timo; Haglund Caj; Salmenkivi Kaisa; Stenman Ulf-Håkan; Andersson Sture
Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat.
Pediatric research 2006;60(4):395-400.
2006: Määttä Marko; Kari Osmo; Tervahartiala Taina; Peltonen Sirje; Kari Marjatta; Saari Matti; Sorsa Timo
Tear fluid levels of MMP-8 are elevated in ocular rosacea--treatment effect of oral doxycycline.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2006;244(8):957-62.
2006: Merrell Melinda A; Ilvesaro Joanna M; Lehtonen Niko; Sorsa Timo; Gehrs Bradley; Rosenthal Eben; Chen Dongquan; Shackley Brit; Harris Kevin W; Selander Katri S
Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity.
Molecular cancer research : MCR 2006;4(7):437-47.
2006: Emingil Gülnur; Kuula Heidi; Pirilä Emma; Atilla Gül; Sorsa Timo
Gingival crevicular fluid laminin-5 gamma2-chain levels in periodontal disease.
Journal of clinical periodontology 2006;33(7):462-8.
2006: Raulo Saara M; Sorsa Timo; Maisi Päivi
In vitro inhibition of matrix metalloproteinase activity in tracheal epithelial lining fluid from horses with recurrent airway obstruction.
American journal of veterinary research 2006;67(7):1252-7.
2006: Järvensivu A; Rautemaa R; Sorsa T; Richardson M
Specificity of the monoclonal antibody 3H8 in the immunohistochemical identification of Candida species.
Oral diseases 2006;12(4):428-33.
2006: Määttä Marko; Tervahartiala Taina; Vesti Eija; Airaksinen Juhani; Sorsa Timo
Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma.
Journal of glaucoma 2006;15(3):229-37.
2006: Lindberg R L P; Sorsa T; Tervahartiala T; Hoffmann F; Mellanen L; Kappos L; Schaad U B; Leib S L; Leppert D
Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children.
Neuropathology and applied neurobiology 2006;32(3):304-17.
2006: Swartz Michael F; Halter Jeffrey M; Fink Gregory W; Pavone Lucio; Zaitsev Alexey; Lee Hsi-Ming; Steinberg Jay M; Lutz Charles J; Sorsa Timo; Gatto Louis A; Landas Steve; Hare Christopher; Nieman Gary F
Chemically modified tetracycline improves contractility in porcine coronary ischemia/reperfusion injury.
Journal of cardiac surgery 2006;21(3):254-60.
2006: Rajamäki Minna M; Järvinen Anna-Kaisa; Sorsa Timo A; Tervahartiala Taina I; Maisi Päivi S
Elevated levels of fragmented laminin-5 gamma2-chain in bronchoalveolar lavage fluid from dogs with pulmonary eosinophilia.
Veterinary journal (London, England : 1997) 2006;171(3):562-5.
2006: Nyberg Pia; Ylipalosaari Merja; Sorsa Timo; Salo Tuula
Trypsins and their role in carcinoma growth.
Experimental cell research 2006;312(8):1219-28.
2006: Heikkilä Pia; Suojanen Juho; Pirilä Emma; Väänänen Anu; Koivunen Erkki; Sorsa Timo; Salo Tuula
Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides.
International journal of cancer. Journal international du cancer 2006;118(9):2202-9.
2006: Emingil Gülnur; Kuula Heidi; Sorsa Timo; Atilla Gül
Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease.
Journal of periodontology 2006;77(4):664-71.
2006: Björklund Mikael; Aitio Olli; Stefanidakis Michael; Suojanen Juho; Salo Tuula; Sorsa Timo; Koivunen Erkki
Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment.
Biochemistry 2006;45(9):2862-71.
2006: Eviö S; Tarkkila L; Sorsa T; Furuholm J; Välimäki M J; Ylikorkala O; Tiitinen A; Meurman J H
Effects of alendronate and hormone replacement therapy, alone and in combination, on saliva, periodontal conditions and gingival crevicular fluid matrix metalloproteinase-8 levels in women with osteoporosis.
Oral diseases 2006;12(2):187-93.
2006: Safkan-Seppälä Bedia; Sorsa Timo; Tervahartiala Taina; Beklen Arzu; Konttinen Yrjö T
Collagenases in gingival crevicular fluid in type 1 diabetes mellitus.
Journal of periodontology 2006;77(2):189-94.
2006: Avellan N-L; Kemppainen P; Tervahartiala T; Vilppola P; Forster C; Sorsa T
Capsaicin-induced local elevations in collagenase-2 (matrix metalloproteinase-8) levels in human gingival crevice fluid.
Journal of periodontal research 2006;41(1):33-8.
2006: Simonen-Jokinen Terhi; Maisi Päivi; Tervahartiala Taina; McGorum Bruce; Pirie Scott; Sorsa Timo
Direct activation of gelatinase B (MMP-9) by hay dust suspension and different components of organic dust.
Veterinary immunology and immunopathology 2006;109(3-4):289-95.
2006: Cox S W; Eley B M; Kiili M; Asikainen A; Tervahartiala T; Sorsa T
Collagen degradation by interleukin-1beta-stimulated gingival fibroblasts is accompanied by release and activation of multiple matrix metalloproteinases and cysteine proteinases.
Oral diseases 2006;12(1):34-40.
2006: Beklen A; Tüter G; Sorsa T; Hanemaaijer R; Virtanen I; Tervahartiala T; Konttinen Y T
Gingival tissue and crevicular fluid co-operation in adult periodontitis.
Journal of dental research 2006;85(1):59-63.
2006: Sorsa Timo; Tjäderhane Leo; Konttinen Yrjö T; Lauhio Anneli; Salo Tuula; Lee Hsi-Ming; Golub Lorne M; Brown David L; Mäntylä Päivi
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Annals of medicine 2006;38(5):306-21.
2006: Sirén Vappu; Salmenperä Pertteli; Kankuri Esko; Bizik Jozef; Sorsa Timo; Tervahartiala Taina; Vaheri Antti
Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases.
Annals of medicine 2006;38(3):212-20.
2005: Raitio Anina; Tuomas Hans; Kokkonen Nina; Salo Tuula; Sorsa Timo; Hanemaaijer Roeland; Oikarinen Aarne
Levels of matrix metalloproteinase-2, -9 and -8 in the skin, serum and saliva of smokers and non-smokers.
Archives of dermatological research 2005;297(6):242-8.
2005: Stenman Mathias; Ainola Mari; Valmu Leena; Bjartell Anders; Ma Guofeng; Stenman Ulf-Håkan; Sorsa Timo; Luukkainen Reijo; Konttinen Yrjö T
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue.
The American journal of pathology 2005;167(4):1119-24.
2005: Kostamo K; Sorsa T; Leino M; Tervahartiala T; Alenius H; Richardson M; Toskala E
In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis.
Allergy 2005;60(10):1275-9.
2005: Sandler Charlotta; Nurmi Katariina; Lindstedt Ken A; Sorsa Timo; Golub Lorne M; Kovanen Petri T; Eklund Kari K
Chemically modified tetracyclines induce apoptosis in cultured mast cells.
International immunopharmacology 2005;5(11):1611-21.
2005: Ylipalosaari M; Thomas G J; Nystrom M; Salhimi S; Marshall J F; Huotari V; Tervahartiala T; Sorsa T; Salo T
Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells.
Experimental cell research 2005;309(2):273-83.
2005: Parikka Vilhelmiina; Väänänen Anu; Risteli Juha; Salo Tuula; Sorsa Timo; Väänänen H Kalervo; Lehenkari Petri
Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(6):438-47.
2005: Sandler C; Ekokoski E; Lindstedt K A; Vainio P J; Finel M; Sorsa T; Kovanen P T; Golub L M; Eklund K K
Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54(7):304-12.
2005: Heljasvaara Ritva; Nyberg Pia; Luostarinen Jani; Parikka Mataleena; Heikkilä Pia; Rehn Marko; Sorsa Timo; Salo Tuula; Pihlajaniemi Taina
Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases.
Experimental cell research 2005;307(2):292-304.
2005: Ingman Tuula; Apajalahti Satu; Mäntylä Päivi; Savolainen Pirjo; Sorsa Timo
Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation.
European journal of orthodontics 2005;27(2):202-7.
2005: Avellan N-L; Sorsa T; Tervahartiala T; Mäntylä P; Forster C; Kemppainen P
Painful tooth stimulation elevates matrix metalloproteinase-8 levels locally in human gingival crevicular fluid.
Journal of dental research 2005;84(4):335-9.
2005: Määttä Marko; Tervahartiala Taina; Harju Mika; Airaksinen Juhani; Autio-Harmainen Helena; Sorsa Timo
Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma.
Journal of glaucoma 2005;14(1):64-9.
2005: Gu Ying; Lee Hsi-Ming; Golub Lorne M; Sorsa Timo; Konttinen Yrjö T; Simon Sanford R
Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines.
Annals of medicine 2005;37(6):450-60.
2004: Sorsa T; Tjäderhane L; Salo T
Matrix metalloproteinases (MMPs) in oral diseases.
Oral diseases 2004;10(6):311-8.
2004: Emingil Gülnur; Atilla Gül; Sorsa Timo; Savolainen Pirjo; Baylas Haluk
Effectiveness of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid laminin-5 gamma2 chain levels in chronic periodontitis.
Journal of periodontology 2004;75(10):1387-96.
2004: Rautemaa R; Järvensivu A; Kari K; Wahlgren J; DeCarlo A; Richardson M; Sorsa T
Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients.
Oral diseases 2004;10(5):298-305.
2004: Hakulinen Juha; Junnikkala Sami; Sorsa Timo; Meri Seppo
Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form.
European journal of immunology 2004;34(9):2620-9.
2004: Järvensivu A; Hietanen J; Rautemaa R; Sorsa T; Richardson M
Candida yeasts in chronic periodontitis tissues and subgingival microbial biofilms in vivo.
Oral diseases 2004;10(2):106-12.
2004: Pirttiniemi Pertti; Kantomaa Tuomo; Sorsa Timo
Effect of decreased loading on the metabolic activity of the mandibular condylar cartilage in the rat.
European journal of orthodontics 2004;26(1):1-5.
2004: Emingil Gülnur; Atilla Gül; Sorsa Timo; Luoto Hanne; Kirilmaz Levent; Baylas Haluk
The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.
Journal of periodontology 2004;75(1):106-15.
2004: Mäntylä P; Stenman M; Paldanius M; Saikku P; Sorsa T; Meurman J H
Chlamydia pneumoniae together with collagenase-2 (MMP-8) in periodontal lesions.
Oral diseases 2004;10(1):32-5.
2003: Ma Jian; Kitti Uula; Hanemaaijer Roeland; Teronen Olli P; Sorsa Timo A; Natah Sirajedin; Tensing Eve-Kai; Konttinen Yrjö T
Gelatinase B is associated with peri-implant bone loss.
Clinical oral implants research 2003;14(6):709-13.
2003: Kivelä-Rajamäki Marjo; Maisi Päivi; Srinivas Ravi; Tervahartiala Taina; Teronen Olli; Husa Ville; Salo Tuula; Sorsa Timo
Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.
Journal of periodontal research 2003;38(6):583-90.
2003: Ma Jian; Sorsa Timo; Billinghurst Clark R; Poole Robin A; Kitti Uula; Santavirta Seppo; Konttinen Yrjö T
Direct evidence of collagenolysis in chronic periodontitis.
Journal of periodontal research 2003;38(6):564-7.
2003: Apajalahti S; Sorsa T; Railavo S; Ingman T
The in vivo levels of matrix metalloproteinase-1 and -8 in gingival crevicular fluid during initial orthodontic tooth movement.
Journal of dental research 2003;82(12):1018-22.
2003: Cederqvist Katariina; Haglund Caj; Heikkilä Päivi; Sorsa Timo; Tervahartiala Taina; Stenman Ulf-Håkan; Andersson Sture
Pulmonary trypsin-2 in the development of bronchopulmonary dysplasia in preterm infants.
Pediatrics 2003;112(3 Pt 1):570-7.
2003: Maitra Subir R; Bhaduri Sikha; Valane Patrick D; Tervahartiala Taina; Sorsa Timo; Ramamurthy Nungavarm
Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis.
Shock (Augusta, Ga.) 2003;20(3):280-5.
2003: Apajalahti Satu; Sorsa Timo; Ingman Tuula
Matrix metalloproteinase -2, -8, -9, and -13 in gingival crevicular fluid of short root anomaly patients.
European journal of orthodontics 2003;25(4):365-9.
2003: Mäntylä Päivi; Stenman Mathias; Kinane Denis F; Tikanoja Sari; Luoto Hanne; Salo Tuula; Sorsa Timo
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis.
Journal of periodontal research 2003;38(4):436-9.
2003: Kinane D F; Darby I B; Said S; Luoto H; Sorsa T; Tikanoja S; Mäntylä P
Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance.
Journal of periodontal research 2003;38(4):400-4.
2003: Holopainen Juha M; Moilanen Jukka A O; Sorsa Timo; Kivelä-Rajamäki Marjo; Tervahartiala Taina; Vesaluoma Minna H; Tervo Timo M T
Activation of matrix metalloproteinase-8 by membrane type 1-MMP and their expression in human tears after photorefractive keratectomy.
Investigative ophthalmology & visual science 2003;44(6):2550-6.
2003: Nyberg Pia; Heikkilä Pia; Sorsa Timo; Luostarinen Jani; Heljasvaara Ritva; Stenman Ulf-Håkan; Pihlajaniemi Taina; Salo Tuula
Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13.
The Journal of biological chemistry 2003;278(25):22404-11.
2003: Steinberg Jay; Halter Jeffrey; Schiller Henry J; Dasilva Monica; Landas Steve; Gatto Louis A; Maisi Paivi; Sorsa Timo; Rajamaki Minna; Lee Hsi-Ming; Nieman Gary F
Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats.
The Journal of surgical research 2003;111(2):185-95.
2003: Heikkilä Pia; Teronen Olli; Hirn Martti Y; Sorsa Timo; Tervahartiala Taina; Salo Tuula; Konttinen Yrjö T; Halttunen Tuula; Moilanen Merja; Hanemaaijer Roeland; Laitinen Minna
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
The Journal of surgical research 2003;111(1):45-52.
2003: Moilanen Merja; Sorsa Timo; Stenman Mathias; Nyberg Pia; Lindy Otso; Vesterinen Jaana; Paju Annukka; Konttinen Yrjö T; Stenman Ulf-Håkan; Salo Tuula
Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen.
Biochemistry 2003;42(18):5414-20.
2003: Pirilä Emma; Sharabi Andrew; Salo Tuula; Quaranta Vito; Tu Hongmin; Heljasvaara Ritva; Koshikawa Naohiko; Sorsa Timo; Maisi Päivi
Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration.
Biochemical and biophysical research communications 2003;303(4):1012-7.
2003: Kivelä-Rajamäki Marjo J; Teronen Olli P; Maisi Päivi; Husa Ville; Tervahartiala Taina I; Pirilä Emma M; Salo Tuula A; Mellanen Liisa; Sorsa Timo A
Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid.
Clinical oral implants research 2003;14(2):158-65.
2003: Wahlgren Jaana; Väänänen Anu; Teronen Olli; Sorsa Timo; Pirilä Emma; Hietanen Jarkko; Maisi Päivi; Tjäderhane Leo; Salo Tuula
Laminin-5 gamma 2 chain is colocalized with gelatinase-A (MMP-2) and collagenase-3 (MMP-13) in odontogenic keratocysts.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2003;32(2):100-7.
2003: Pirilä Emma; Ramamurthy Nungavarm S; Sorsa Timo; Salo Tuula; Hietanen Jarkko; Maisi Päivi
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).
Digestive diseases and sciences 2003;48(1):93-8.
2002: Nyberg P; Moilanen M; Paju A; Sarin A; Stenman U-H; Sorsa T; Salo T
MMP-9 activation by tumor trypsin-2 enhances in vivo invasion of human tongue carcinoma cells.
Journal of dental research 2002;81(12):831-5.
2002: Maisi Päivi; Prikk Kaiu; Sepper Ruth; Pirilä Emma; Salo Tuula; Hietanen Jarkko; Sorsa Timo
Soluble membrane-type 1 matrix metalloproteinase (MT1-MMP) and gelatinase A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(11):771-82.
2002: Rajamäki Minna M; Järvinen Anna-Kaisa; Sorsa Timo; Maisi Päivi
Collagenolytic activity in bronchoalveolar lavage fluid in canine pulmonary eosinophilia.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2002;16(6):658-64.
2002: Wahlgren J; Salo T; Teronen O; Luoto H; Sorsa T; Tjäderhane L
Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates.
International endodontic journal 2002;35(11):897-904.
2002: Henry M T; McMahon K; Mackarel A J; Prikk K; Sorsa T; Maisi P; Sepper R; Fitzgerald M X; O'Connor C M
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;20(5):1220-7.
2002: Prikk Kaiu; Maisi Päivi; Pirilä Emma; Reintam Mari-Ann; Salo Tuula; Sorsa Timo; Sepper Ruth
Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1535-45.
2002: Sulkala M; Larmas M; Sorsa T; Salo T; Tjäderhane L
The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth.
Journal of dental research 2002;81(9):603-7.
2002: Vuotila T; Ylikontiola L; Sorsa T; Luoto H; Hanemaaijer R; Salo T; Tjäderhane L
The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2002;31(6):329-38.
2002: Azmak Nezih; Atilla Gül; Luoto Hanne; Sorsa Timo
The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid.
Journal of periodontology 2002;73(6):608-15.
2002: Palosaari H; Ding Y; Larmas M; Sorsa T; Bartlett J D; Salo T; Tjäderhane L
Regulation and interactions of MT1-MMP and MMP-20 in human odontoblasts and pulp tissue in vitro.
Journal of dental research 2002;81(5):354-9.
2002: Moilanen M; Pirilä E; Grénman R; Sorsa T; Salo T
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
The Journal of pathology 2002;197(1):72-81.
2002: Ma Jian; Sorsa Timo; Könönen Mauno; Santavirta Seppo; Virtanen Ismo; Konttinen Yrjö
Cellular fibronectin in failing dental implants.
The International journal of oral & maxillofacial implants 2002;17(3):363-8.
2002: Knuutinen A; Kokkonen N; Risteli J; Vähäkangas K; Kallioinen M; Salo T; Sorsa T; Oikarinen A
Smoking affects collagen synthesis and extracellular matrix turnover in human skin.
The British journal of dermatology 2002;146(4):588-94.
2002: Rajamäki Minna M; Järvinen Anna-Kaisa; Sorsa Timo; Maisi Päivi
Clinical findings, bronchoalveolar lavage fluid cytology and matrix metalloproteinase-2 and -9 in canine pulmonary eosinophilia.
Veterinary journal (London, England : 1997) 2002;163(2):168-81.
2002: Heikkilä Pia; Teronen Olli; Moilanen Merja; Konttinen Yrjö T; Hanemaaijer Roeland; Laitinen Minna; Maisi Päivi; van der Pluijm Gabri; Bartlett John D; Salo Tuula; Sorsa Timo
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines.
Anti-cancer drugs 2002;13(3):245-54.
2002: Raulo S M; Sorsa T; Tervahartiala T; Latvanen T; Pirilä E; Hirvonen J; Maisi P
Increase in milk metalloproteinase activity and vascular permeability in bovine endotoxin-induced and naturally occurring Escherichia coli mastitis.
Veterinary immunology and immunopathology 2002;85(3-4):137-45.
2002: Kiili M; Cox S W; Chen H Y; Wahlgren J; Maisi P; Eley B M; Salo T; Sorsa T;
Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue.
Journal of clinical periodontology 2002;29(3):224-32.
2002: Nevalainen M; Raulo S M; Brazil T J; Pirie R S; Sorsa T; McGorum B C; Maisi P
Inhalation of organic dusts and lipopolysaccharide increases gelatinolytic matrix metalloproteinases (MMPs) in the lungs of heaves horses.
Equine veterinary journal 2002;34(2):150-5.
2002: Pirilä Emma; Parikka Mataleens; Ramamurthy Nungavarm S; Maisi Päivi; McClain Steve; Kucine Allan; Tervahartiala Taina; Prikk Kaiu; Golub Lorne M; Salo Tuula; Sorsa Timo
Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(1):38-51.
2002: Buduneli Nurcan; Vardar Saynur; Atilla Gül; Sorsa Timo; Luoto Hanne; Baylas Haluk
Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase of periodontal therapy.
Journal of periodontology 2002;73(1):103-9.
2001: Väänänen A; Srinivas R; Parikka M; Palosaari H; Bartlett J D; Iwata K; Grenman R; Stenman U H; Sorsa T; Salo T
Expression and regulation of MMP-20 in human tongue carcinoma cells.
Journal of dental research 2001;80(10):1884-9.
2001: Konttinen Y T; Takagi M; Mandelin J; Lassus J; Salo J; Ainola M; Li T F; Virtanen I; Liljestrom M; Sakai H; Kobayashi Y; Sorsa T; Lappalainen R; Demulder A; Santavirta S
Acid attack and cathepsin K in bone resorption around total hip replacement prosthesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1780-6.
2001: Mellanen L; Sorsa T; Lähdevirta J; Helenius M; Kari K; Meurman J H
Salivary albumin, total protein, IgA, IgG and IgM concentrations and occurrence of some periodontopathogens in HIV-infected patients: a 2-year follow-up study.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2001;30(9):553-9.
2001: Prikk K; Maisi P; Sepper R; Stenman U H; Salo T; Sorsa T
Association of trypsin-2 with activation of gelatinase B and collagenase-2 in human bronchoalveolar lavage fluid in vivo.
Annals of medicine 2001;33(6):437-44.
2001: Pirilä E; Maisi P; Salo T; Koivunen E; Sorsa T
In vivo localization of gelatinases (MMP-2 and -9) by in situ zymography with a selective gelatinase inhibitor.
Biochemical and biophysical research communications 2001;287(3):766-74.
2001: Cederqvist K; Sorsa T; Tervahartiala T; Maisi P; Reunanen K; Lassus P; Andersson S
Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress.
Pediatrics 2001;108(3):686-92.
2001: Tjäderhane L; Palosaari H; Wahlgren J; Larmas M; Sorsa T; Salo T
Human odontoblast culture method: the expression of collagen and matrix metalloproteinases (MMPs).
Advances in dental research 2001;15():55-8.
2001: Llavaneras A; Ramamurthy N S; Heikkilä P; Teronen O; Salo T; Rifkin B R; Ryan M E; Golub L M; Sorsa T
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
Journal of periodontology 2001;72(8):1069-77.
2001: Raulo S M; Sorsa T A; Kiili M T; Maisi P S
Evaluation of collagenase activity, matrix metalloproteinase-8, and matrix metalloproteinase-13 in horses with chronic obstructive pulmonary disease.
American journal of veterinary research 2001;62(7):1142-8.
2001: Sulkala M; Wahlgren J; Larmas M; Sorsa T; Teronen O; Salo T; Tjäderhane L
The effects of MMP inhibitors on human salivary MMP activity and caries progression in rats.
Journal of dental research 2001;80(6):1545-9.
2001: Tervahartiala T; Koski H; Xu J W; Häyrinen-Immonen R; Hietanen J; Sorsa T; Konttinen Y T
Tumor necrosis factor-alpha and its receptors, p55 and p75, in gingiva of adult periodontitis.
Journal of dental research 2001;80(6):1535-9.
2001: Prikk K; Maisi P; Pirilä E; Sepper R; Salo T; Wahlgren J; Sorsa T
In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis.
The Journal of pathology 2001;194(2):232-8.
2001: Wahlgren J; Maisi P; Sorsa T; Sutinen M; Tervahartiala T; Pirilä E; Teronen O; Hietanen J; Tjäderhane L; Salo T
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
The Journal of pathology 2001;194(2):217-24.
2001: Paju A; Sorsa T; Tervahartiala T; Koivunen E; Haglund C; Leminen A; Wahlström T; Salo T; Stenman U H
The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation.
British journal of cancer 2001;84(10):1363-71.
2001: Srinivas R; Sorsa T; Tjäderhane L; Niemi E; Raustia A; Pernu H; Teronen O; Salo T
Matrix metalloproteinases in mild and severe temporomandibular joint internal derangement synovial fluid.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2001;91(5):517-25.
2001: Atilla G; Sorsa T; Rönka H; Emingil G
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients.
Journal of periodontology 2001;72(3):354-60.
2001: Koski H; Janin A; Humphreys-Beher M G; Sorsa T; Malmström M; Konttinen Y T
Tumor necrosis factor-alpha and receptors for it in labial salivary glands in Sjögren's syndrome.
Clinical and experimental rheumatology 2001;19(2):131-7.
2001: Raulo S M; Sorsa T; Tervahartiala T; Pirilä E; Maisi P
MMP-9 as a marker of inflammation in tracheal epithelial lining fluid (TELF) and in bronchoalveolar fluid (BALF) of COPD horses.
Equine veterinary journal 2001;33(2):128-36.
2001: Sorsa T; Heikkinen S; Abbott M B; Abusamhadneh E; Laakso T; Tilgmann C; Serimaa R; Annila A; Rosevear P R; Drakenberg T; Pollesello P; Kilpelainen I
Binding of levosimendan, a calcium sensitizer, to cardiac troponin C.
The Journal of biological chemistry 2001;276(12):9337-43.
2001: Pirilä E; Ramamurthy N; Maisi P; McClain S; Kucine A; Wahlgren J; Golub L; Salo T; Sorsa T
Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression.
Current medicinal chemistry 2001;8(3):281-94.
2001: Lee H M; Golub L M; Cao J; Teronen O; Laitinen M; Salo T; Zucker S; Sorsa T
CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMP activity: relevance to cancer.
Current medicinal chemistry 2001;8(3):257-60.
2000: Tervahartiala T; Pirilä E; Ceponis A; Maisi P; Salo T; Tuter G; Kallio P; Törnwall J; Srinivas R; Konttinen Y T; Sorsa T
The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis.
Journal of dental research 2000;79(12):1969-77.
2000: Ma J; Kitti U; Teronen O; Sorsa T; Husa V; Laine P; Rönkä H; Salo T; Lindqvist C; Konttinen Y T
Collagenases in different categories of peri-implant vertical bone loss.
Journal of dental research 2000;79(11):1870-3.
2000: Konttinen Y T; Ramsay H; Hietanen J; Sorsa T; Nordstrom D
Otitis externa sicca/fibrotising external otitis (FEO) as a complication of Sjögren's syndrome.
Clinical and experimental rheumatology 2000;18(6):746-8.
2000: Pääkkönen K; Sorsa T; Drakenberg T; Pollesello P; Tilgmann C; Permi P; Heikkinen S; Kilpeläinen I; Annila A
Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings.
European journal of biochemistry / FEBS 2000;267(22):6665-72.
2000: Collin H L; Sorsa T; Meurman J H; Niskanen L; Salo T; Rönkä H; Konttinen Y T; Koivisto A M; Uusitupa M
Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus.
Journal of periodontal research 2000;35(5):259-65.
2000: Raulo S M; Sorsa T A; Maisi P S
Concentrations of elastinolytic metalloproteinases in respiratory tract secretions of healthy horses and horses with chronic obstructive pulmonary disease.
American journal of veterinary research 2000;61(9):1067-73.
2000: Valleala H; Teronen O; Friman C; Sorsa T; Solovieva S; Konttinen Y T
Inhibition of collagenase by a bisphosphonate-group drug in patients with rheumatoid arthritis.
The Journal of rheumatology 2000;27(6):1570-2.
2000: Chen H Y; Cox S W; Eley B M; Mäntylä P; Rönkä H; Sorsa T
Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients.
Journal of clinical periodontology 2000;27(5):366-9.
2000: Lukkonen A; Sorsa T; Salo T; Tervahartiala T; Koivunen E; Golub L; Simon S; Stenman U H
Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration.
International journal of cancer. Journal international du cancer 2000;86(4):577-81.
2000: Levijoki J; Pollesello P; Kaivola J; Tilgmann C; Sorsa T; Annila A; Kilpeläinen I; Haikala H
Further evidence for the cardiac troponin C mediated calcium sensitization by levosimendan: structure-response and binding analysis with analogs of levosimendan.
Journal of molecular and cellular cardiology 2000;32(3):479-91.
2000: Konttinen Y T; Li T F; Mandelin J; Liljeström M; Sorsa T; Santavirta S; Virtanen I
Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium.
Arthritis and rheumatism 2000;43(2):275-80.
2000: Palosaari H; Wahlgren J; Larmas M; Rönkä H; Sorsa T; Salo T; Tjäderhane L
The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1.
Journal of dental research 2000;79(1):77-84.
2000: Konttinen Y T; Hietanen J; Virtanen I; Ma J; Sorsa T; Xu J W; Williams N P; Manthorpe R; Janin A
Mast cell derangement in salivary glands in patients with Sjögren's syndrome.
Rheumatology international 2000;19(4):141-7.
1999: Konttinen Y T; Kemppinen P; Li T F; Waris E; Pihlajamäki H; Sorsa T; Takagi M; Santavirta S; Schultz G S; Humphreys-Beher M G
Transforming and epidermal growth factors in degenerated intervertebral discs.
The Journal of bone and joint surgery. British volume 1999;81(6):1058-63.
1999: Said S; Mohd H; Sander L; Rönkä H; Sorsa T; Kinane D F
GCF levels of MMP-3 and MMP-8 following placement of bioresorbable membranes.
Journal of clinical periodontology 1999;26(11):757-63.
1999: Liede K E; Haukka J K; Hietanen J H; Mattila M H; Rönkä H; Sorsa T
The association between smoking cessation and periodontal status and salivary proteinase levels.
Journal of periodontology 1999;70(11):1361-8.
1999: Konttinen Y T; Ainola M; Valleala H; Ma J; Ida H; Mandelin J; Kinne R W; Santavirta S; Sorsa T; López-Otín C; Takagi M
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58(11):691-7.
1999: Konttinen Y T; Salo T; Hanemaaijer R; Valleala H; Sorsa T; Sutinen M; Ceponis A; Xu J W; Santavirta S; Teronen O; López-Otín C
Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(4):401-12.
1999: Mäkelä M; Larjava H; Pirilä E; Maisi P; Salo T; Sorsa T; Uitto V J
Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes.
Experimental cell research 1999;251(1):67-78.
1999: Koivunen E; Arap W; Valtanen H; Rainisalo A; Medina O P; Heikkilä P; Kantor C; Gahmberg C G; Salo T; Konttinen Y T; Sorsa T; Ruoslahti E; Pasqualini R
Tumor targeting with a selective gelatinase inhibitor.
Nature biotechnology 1999;17(8):768-74.
1999: Ramamurthy N S; McClain S A; Pirila E; Maisi P; Salo T; Kucine A; Sorsa T; Vishram F; Golub L M
Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis.
Annals of the New York Academy of Sciences 1999;878():720-3.
1999: Tjäderhane L; Sulkala M; Sorsa T; Teronen O; Larmas M; Salo T
The effect of MMP inhibitor metastat on fissure caries progression in rats.
Annals of the New York Academy of Sciences 1999;878():686-8.
1999: Sepper R; Prikk K; Tervahartiala T; Konttinen Y T; Maisi P; Lópes-Otín C; Sorsa T
Collagenase-2 and -3 are inhibited by doxycycline in the chronically inflamed lung in bronchiectasis.
Annals of the New York Academy of Sciences 1999;878():683-5.
1999: Maisi P; Kiili M; Raulo S M; Pirilä E; Sorsa T
MMP inhibition by chemically modified tetracycline-3 (CMT-3) in equine pulmonary epithelial lining fluid.
Annals of the New York Academy of Sciences 1999;878():675-7.
1999: Llavaneras A; Golub L M; Rifkin B R; Heikkilä P; Sorsa T; Teronen O; Salo T; Liu Y; Ryan M E; Ramamurthy N S
CMT-8/clodronate combination therapy synergistically inhibits alveolar bone loss in LPS-induced periodontitis.
Annals of the New York Academy of Sciences 1999;878():671-4.
1999: Teronen O; Heikkilä P; Konttinen Y T; Laitinen M; Salo T; Hanemaaijer R; Teronen A; Maisi P; Sorsa T
MMP inhibition and downregulation by bisphosphonates.
Annals of the New York Academy of Sciences 1999;878():453-65.
1999: Golub L M; Ramamurthy N S; Llavaneras A; Ryan M E; Lee H M; Liu Y; Bain S; Sorsa T
A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.
Annals of the New York Academy of Sciences 1999;878():290-310.
1999: Sorsa T; Mäntylä P; Rönkä H; Kallio P; Kallis G B; Lundqvist C; Kinane D F; Salo T; Golub L M; Teronen O; Tikanoja S
Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease.
Annals of the New York Academy of Sciences 1999;878():130-40.
1999: Konttinen Y T; Valleala H; Honkanen V; Törnwall J; Tensing E K; Sorsa T; Nordström D
[Tumor necrosis factor modulators in the treatment of rheumatoid arthritis]
Duodecim; lääketieteellinen aikakauskirja 1999;115(18):1969-76.
1999: Konttinen Y T; Kemppinen P; Koski H; Li T F; Jumppanen M; Hietanen J; Santavirta S; Salo T; Larsson A; Hakala M; Sorsa T
T(H)1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals.
Scandinavian journal of rheumatology 1999;28(2):106-12.
1999: Laitinen M; Halttunen T; Jortikka L; Teronen O; Sorsa T; Lindholm T S
The role of transforming growth factor-beta on retarded osteoblastic differentiation in vitro.
Life sciences 1999;64(10):847-58.
1998: Konttinen Y T; Ceponis A; Takagi M; Ainola M; Sorsa T; Sutinen M; Salo T; Ma J; Santavirta S; Seiki M
New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(8-9):585-601.
1998: Ceponis A; Konttinen Y T; Takagi M; Xu J W; Sorsa T; Matucci-Cerinic M; Santavirta S; Bankl H C; Valent P
Expression of stem cell factor (SCF) and SCF receptor (c-kit) in synovial membrane in arthritis: correlation with synovial mast cell hyperplasia and inflammation.
The Journal of rheumatology 1998;25(12):2304-14.
1998: Mäkelä M; Sorsa T; Uitto V J; Salo T; Teronen O; Larjava H
The effects of chemically modified tetracyclines (CMTs) on human keratinocyte proliferation and migration.
Advances in dental research 1998;12(2):131-5.
1998: Golub L M; Lee H M; Ryan M E; Giannobile W V; Payne J; Sorsa T
Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.
Advances in dental research 1998;12(2):12-26.
1998: Konttinen Y T; Li T F; Michelsson O; Xu J W; Sorsa T; Santavirta S; Imai S; Virtanen I
Expression of tenascin-C in aseptic loosening of total hip replacement.
Annals of the rheumatic diseases 1998;57(10):619-23.
1998: Konttinen Y T; Halinen S; Hanemaaijer R; Sorsa T; Hietanen J; Ceponis A; Xu J W; Manthorpe R; Whittington J; Larsson A; Salo T; Kjeldsen L; Stenman U H; Eisen A Z
Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren's syndrome.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(5):335-47.
1998: Kotiranta A; Haapasalo M; Kari K; Kerosuo E; Olsen I; Sorsa T; Meurman J H; Lounatmaa K
Surface structure, hydrophobicity, phagocytosis, and adherence to matrix proteins of Bacillus cereus cells with and without the crystalline surface protein layer.
Infection and immunity 1998;66(10):4895-902.
1998: Imai S; Konttinen Y T; Jumppanen M; Lindy O; Ceponis A; Kemppinen P; Sorsa T; Santavirta S; Xu J W; Lopéz-Otín C
High levels of expression of collagenase-3 (MMP-13) in pathological conditions associated with a foreign-body reaction.
The Journal of bone and joint surgery. British volume 1998;80(4):701-10.
1998: Santavirta S; Xu J W; Hietanen J; Ceponis A; Sorsa T; Kontio R; Konttinen Y T
Activation of periprosthetic connective tissue in aseptic loosening of total hip replacements.
Clinical orthopaedics and related research 1998;(352):16-24.
1998: Mellanen L; Salo T; Ingman T; Konttinen Y T; Lähdevirta J; Sorsa T
72-kDa and 92-kDa gelatinases in saliva of patients with human immunodeficiency virus infection.
Acta odontologica Scandinavica 1998;56(3):135-42.
1998: Sepper R; Konttinen Y T; Kemppinen P; Sorsa T; Eklund K K
Mast cells in bronchiectasis.
Annals of medicine 1998;30(3):307-15.
1998: Sutinen M; Kainulainen T; Hurskainen T; Vesterlund E; Alexander J P; Overall C M; Sorsa T; Salo T
Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis.
British journal of cancer 1998;77(12):2239-45.
1998: Pääkkönen K; Annila A; Sorsa T; Pollesello P; Tilgmann C; Kilpeläinen I; Karisola P; Ulmanen I; Drakenberg T
Solution structure and main chain dynamics of the regulatory domain (Residues 1-91) of human cardiac troponin C.
The Journal of biological chemistry 1998;273(25):15633-8.
1998: Sorsa T; Ramamurthy N S; Vernillo A T; Zhang X; Konttinen Y T; Rifkin B R; Golub L M
Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases.
The Journal of rheumatology 1998;25(5):975-82.
1998: Joukov V; Kumar V; Sorsa T; Arighi E; Weich H; Saksela O; Alitalo K
A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities.
The Journal of biological chemistry 1998;273(12):6599-602.
1998: Hurskainen T; Seiki M; Apte S S; Syrjäkallio-Ylitalo M; Sorsa T; Oikarinen A; Autio-Harmainen H
Production of membrane-type matrix metalloproteinase-1 (MT-MMP-1) in early human placenta. A possible role in placental implantation?
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(2):221-9.
1998: Greenwald R A; Golub L M; Ramamurthy N S; Chowdhury M; Moak S A; Sorsa T
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Bone 1998;22(1):33-8.
1998: Xu J W; Konttinen Y T; Li T F; Waris V; Lassus J; Matucci-Cerinic M; Sorsa T; Santavirta T S
Production of platelet-derived growth factor in aseptic loosening of total hip replacement.
Rheumatology international 1998;17(6):215-21.
1998: Nordström D; Lindy O; Lauhio A; Sorsa T; Santavirta S; Konttinen Y T
Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis.
Rheumatology international 1998;17(5):175-80.
1997: Sepper R; Konttinen Y T; Buø L; Eklund K K; Lauhio A; Sorsa T; Tschesche H; Aasen A O; Sillastu H
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(12):2788-93.
1997: Seppälä B; Sorsa T; Ainamo J
Morphometric analysis of cellular and vascular changes in gingival connective tissue in long-term insulin-dependent diabetes.
Journal of periodontology 1997;68(12):1237-45.
1997: Hanemaaijer R; Sorsa T; Konttinen Y T; Ding Y; Sutinen M; Visser H; van Hinsbergh V W; Helaakoski T; Kainulainen T; Rönkä H; Tschesche H; Salo T
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline.
The Journal of biological chemistry 1997;272(50):31504-9.
1997: Teronen O; Konttinen Y T; Lindqvist C; Salo T; Ingman T; Lauhio A; Ding Y; Santavirta S; Sorsa T
Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate.
Journal of dental research 1997;76(9):1529-37.
1997: Golub L M; Lee H M; Greenwald R A; Ryan M E; Sorsa T; Salo T; Giannobile W V
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(8):310-9.
1997: Sorsa T; Salo T; Koivunen E; Tyynelä J; Konttinen Y T; Bergmann U; Tuuttila A; Niemi E; Teronen O; Heikkilä P; Tschesche H; Leinonen J; Osman S; Stenman U H
Activation of type IV procollagenases by human tumor-associated trypsin-2.
The Journal of biological chemistry 1997;272(34):21067-74.
1997: Lindy O; Konttinen Y T; Sorsa T; Ding Y; Santavirta S; Ceponis A; López-Otín C
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.
Arthritis and rheumatism 1997;40(8):1391-9.
1997: Joukov V; Sorsa T; Kumar V; Jeltsch M; Claesson-Welsh L; Cao Y; Saksela O; Kalkkinen N; Alitalo K
Proteolytic processing regulates receptor specificity and activity of VEGF-C.
The EMBO journal 1997;16(13):3898-911.
1997: Teronen O; Konttinen Y T; Lindqvist C; Salo T; Ingman T; Lauhio A; Ding Y; Santavirta S; Valleala H; Sorsa T
Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).
Calcified tissue international 1997;61(1):59-61.
1997: Xu J W; Konttinen Y T; Waris V; Pätiälä H; Sorsa T; Santavirta S
Macrophage-colony stimulating factor (M-CSF) is increased in the synovial-like membrane of the periprosthetic tissues in the aseptic loosening of total hip replacement (THR).
Clinical rheumatology 1997;16(3):243-8.
1997: Konttinen Y T; Platts L A; Tuominen S; Eklund K K; Santavirta N; Törnwall J; Sorsa T; Hukkanen M; Polak J M
Role of nitric oxide in Sjögren's syndrome.
Arthritis and rheumatism 1997;40(5):875-83.
1997: Ding Y; Haapasalo M; Kerosuo E; Lounatmaa K; Kotiranta A; Sorsa T
Release and activation of human neutrophil matrix metallo- and serine proteinases during phagocytosis of Fusobacterium nucleatum, Porphyromonas gingivalis and Treponema denticola.
Journal of clinical periodontology 1997;24(4):237-48.
1997: Konttinen Y T; Waris V; Xu J W; Jiranek W A; Sorsa T; Virtanen I; Santavirta S
Transforming growth factor-beta 1 and 2 in the synovial-like interface membrane between implant and bone in loosening of total hip arthroplasty.
The Journal of rheumatology 1997;24(4):694-701.
1997: Saari H; Halinen S; Ganlöv K; Sorsa T; Konttinen Y T
Salivary mucous glycoprotein MG1 in Sjögren's syndrome.
Clinica chimica acta; international journal of clinical chemistry 1997;259(1-2):83-96.
1997: Ylikontiola L; Sorsa T; Häyrinen-Immonen R; Salo T
Doxymycine-cyanoacrylate treatment of recurrent aphthous ulcers.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 1997;83(3):329-33.
1996: Mellanen L; Ingman T; Lähdevirta J; Lauhio A; Ainamo A; Konttinen Y T; Sukura A; Salo T; Sorsa T
Matrix metalloproteinases-1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection.
Oral diseases 1996;2(4):263-71.
1996: Ding Y; Uitto V J; Haapasalo M; Lounatmaa K; Konttinen Y T; Salo T; Grenier D; Sorsa T
Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes.
Journal of dental research 1996;75(12):1986-93.
1996: Konttinen Y T; Ceponis A; Meri S; Vuorikoski A; Kortekangas P; Sorsa T; Sukura A; Santavirta S
Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane.
Annals of the rheumatic diseases 1996;55(12):888-94.
1996: Ingman T; Tervahartiala T; Ding Y; Tschesche H; Haerian A; Kinane D F; Konttinen Y T; Sorsa T
Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients.
Journal of clinical periodontology 1996;23(12):1127-32.
1996: Westerlund U; Ingman T; Lukinmaa P L; Salo T; Kjeldsen L; Borregaard N; Tjäderhane L; Konttinen Y T; Sorsa T
Human neutrophil gelatinase and associated lipocalin in adult and localized juvenile periodontitis.
Journal of dental research 1996;75(8):1553-63.
1996: Teronen O; Hietanen J; Lindqvist C; Salo T; Sorsa T; Eklund K K; Sommerhoff C P; Ylipaavalniemi P; Konttinen Y T
Mast cell-derived tryptase in odontogenic cysts.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1996;25(7):376-81.
1996: Halinen S; Sorsa T; Ding Y; Ingman T; Salo T; Konttinen Y T; Saari H
Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down's syndrome.
Journal of periodontology 1996;67(8):748-54.
1996: Konttinen Y T; Törnwall J; Kemppinen P; Uusitalo H; Sorsa T; Hukkanen M; Polak J M
Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjögren's syndrome.
Annals of the rheumatic diseases 1996;55(8):513-9.
1996: Weckroth M; Vaheri A; Lauharanta J; Sorsa T; Konttinen Y T
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
The Journal of investigative dermatology 1996;106(5):1119-24.
1996: Tervahartiala T; Konttinen Y T; INgman T; Häyrinen-Immonen R; Ding Y; Sorsa T
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Journal of clinical periodontology 1996;23(2):68-75.
1996: Nordstrom D; Lindy O; Konttinen Y T; Lauhio A; Sorsa T; Friman C; Pettersson T; Santavirta S
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Clinical rheumatology 1996;15(1):35-41.
1996: Solovieva S A; Ceponis A; Konttinen Y T; Takagi M; Suda A; Eklund K K; Sorsa T; Santavirta S
Mast cells in loosening of totally replaced hips.
Clinical orthopaedics and related research 1996;(322):158-65.
1996: Waris V; Xu J W; Nordsletten L; Sorsa T; Santavirta S; Konttinen Y T
Basic fibroblast growth factor (bFGF) in the synovial-like membrane around loose total hip prostheses.
Scandinavian journal of rheumatology 1996;25(4):257-62.
1995: Takagi M; Konttinen Y T; Kemppinen P; Sorsa T; Tschesche H; Bläser J; Suda A; Santavirta S
Tissue inhibitor of metalloproteinase 1, collagenolytic and gelatinolytic activity in loose hip endoprostheses.
The Journal of rheumatology 1995;22(12):2285-90.
1995: Ding Y; Uitto V J; Firth J; Salo T; Haapasalo M; Konttinen Y T; Sorsa T
Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.
Oral diseases 1995;1(4):279-86.
1995: Lauhio A; Salo T; Tjäderhane L; Lähdevirta J; Golub L M; Sorsa T
Tetracyclines in treatment of rheumatoid arthritis.
Lancet 1995;346(8975):645-6.
1995: Sorsa T; Ding Y L; Ingman T; Salo T; Westerlund U; Haapasalo M; Tschesche H; Konttinen Y T
Cellular source, activation and inhibition of dental plaque collagenase.
Journal of clinical periodontology 1995;22(9):709-17.
1995: Törnwall J; Konttinen Y T; Hietanen J; Sorsa T; Hukkanen M; Uusitalo H
VIP in salivary glands in Sjögren's syndrome.
British journal of rheumatology 1995;34(9):891-3.
1995: Sepper R; Konttinen Y T; Ding Y; Takagi M; Sorsa T
Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease.
Chest 1995;107(6):1641-7.
1995: Teronen O; Salo T; Laitinen J; Törnwall J; Ylipaavalniemi P; Konttinen Y T; Hietanen J; Sorsa T
Characterization of interstitial collagenases in jaw cyst wall.
European journal of oral sciences 1995;103(3):141-7.
1995: Sukura A; Konttinen Y T; Sepper R; Kaartinen L; Sorsa T; Lindberg L A
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Journal of clinical microbiology 1995;33(4):829-34.
1995: Takagi M; Konttinen Y T; Santavirta S; Kangaspunta P; Sorsa T; Yamakawa M; Suda A
Elastase activity, uninhibited by alpha 1-antitrypsin, in the periprosthetic connective matrix around loose total hip prostheses.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(2):296-304.
1995: Teronen O; Salo T; Konttinen Y T; Rifkin B; Vernillo A; Ramamurthy N S; Kjeldsen L; Borregaard N; Hietanen J; Sorsa T
Identification and characterization of gelatinases/type IV collagenases in jaw cysts.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1995;24(2):78-84.
1995: Tervahartiala T; Ingman T; Sorsa T; Ding Y; Kangaspunta P; Konttinen Y T
Proteolytic enzymes as indicators of periodontal health in gingival crevicular fluid of patients with Sjögren's syndrome.
European journal of oral sciences 1995;103(1):11-6.
1995: Sepper R; Konttinen Y T; Ingman T; Sorsa T
Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis.
Journal of clinical immunology 1995;15(1):27-34.
1994: Ingman T; Sorsa T; Michaelis J; Konttinen Y T
Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis.
Scandinavian journal of dental research 1994;102(6):342-9.
1994: Konttinen Y T; Kangaspunta P; Lindy O; Takagi M; Sorsa T; Segerberg M; Tschesche H; Eisen A Z
Collagenase in Sjögren's syndrome.
Annals of the rheumatic diseases 1994;53(12):836-9.
1994: Sepper R; Konttinen Y T; Sorsa T; Koski H
Gelatinolytic and type IV collagenolytic activity in bronchiectasis.
Chest 1994;106(4):1129-33.
1994: Lauhio A; Salo T; Ding Y; Konttinen Y T; Nordström D; Tschesche H; Lähdevirta J; Golub L M; Sorsa T
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis.
Clinical and experimental immunology 1994;98(1):21-8.
1994: Takagi M; Konttinen Y T; Lindy O; Sorsa T; Kurvinen H; Suda A; Santavirta S
Gelatinase/type IV collagenases in the loosening of total hip replacement endoprostheses.
Clinical orthopaedics and related research 1994;(306):136-44.
1994: Teronen O; Salo T; Konttinen Y T; Rifkin B; Vernillo A; Ramamurthy N S; Kjeldsen L; Borregaard N; Sommerhoff C P; Sorsa T
Gelatinases/type IV collagenases in jaw cyst expansion.
Annals of the New York Academy of Sciences 1994;732():486-8.
1994: Salo T; Sorsa T; Lauhio A; Konttinen Y T; Ainamo A; Kjeldsen L; Borregaard N; Ranta H; Lähdevirta J
Matrix metalloproteinases, their endogenous inhibitors, and microbial activators in gingival crevicular fluid and saliva of HIV(+)-subjects.
Annals of the New York Academy of Sciences 1994;732():476-8.
1994: Ingman T; Sorsa T; Michaelis J; Konttinen Y T
Matrix metalloproteinases-1, -3, and -8 in adult periodontitis in situ. An immunohistochemical study.
Annals of the New York Academy of Sciences 1994;732():459-61.
1994: Ding Y; Liede K; Leppä S; Ingman T; Sepper R; Konttinen Y T; Sorsa T
Gingival crevicular fluid and salivary matrix metalloproteinases of heavy smokers as indicators of periodontal health.
Annals of the New York Academy of Sciences 1994;732():453-5.
1994: Lauhio A; Konttinen Y T; Salo T; Tschesche H; Nordström D; Lähdevirta J; Golub L M; Sorsa T
The in vivo effect of doxycycline treatment on matrix metalloproteinases in reactive arthritis.
Annals of the New York Academy of Sciences 1994;732():431-2.
1994: Lauhio A; Konttinen Y T; Salo T; Tschesche H; Lähdevirta J; Woessner F; Golub L M; Sorsa T
Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis.
Annals of the New York Academy of Sciences 1994;732():424-6.
1994: Sorsa T; Ding Y; Salo T; Lauhio A; Teronen O; Ingman T; Ohtani H; Andoh N; Takeha S; Konttinen Y T
Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases.
Annals of the New York Academy of Sciences 1994;732():112-31.
1994: Konttinen Y T; Kemppinen P; Segerberg M; Hukkanen M; Rees R; Santavirta S; Sorsa T; Pertovaara A; Polak J M
Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain.
Arthritis and rheumatism 1994;37(7):965-82.
1994: Häyrinen-Immonen R; Sorsa T; Pettilä J; Konttinen Y T; Teronen O; Malmström M
Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1994;23(6):269-72.
1994: Ingman T; Sorsa T; Kangaspunta P; Konttinen Y T
Elastase and alpha-1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis.
Journal of periodontology 1994;65(7):702-9.
1994: Takagi M; Konttinen Y T; Santavirta S; Sorsa T; Eisen A Z; Nordsletten L; Suda A
Extracellular matrix metalloproteinases around loose total hip prostheses.
Acta orthopaedica Scandinavica 1994;65(3):281-6.
1994: Törnwall J; Uusitalo H; Hukkanen M; Sorsa T; Konttinen Y T
Distribution of vasoactive intestinal peptide (VIP) and its binding sites in labial salivary glands in Sjögren's syndrome and in normal controls.
Clinical and experimental rheumatology 1994;12(3):287-92.
1994: Ingman T; Könönen M; Konttinen Y T; Siirilä H S; Suomalainen K; Sorsa T
Collagenase, gelatinase and elastase activities in sulcular fluid of osseointegrated implants and natural teeth.
Journal of clinical periodontology 1994;21(4):301-7.
1994: Konttinen Y T; Hayrinen-Immonen R H; Nordstrom D; Malmstrom M J; Hukkanen M; Sorsa T; Polak J
Innervation of recurrent aphthous ulcers.
Oral microbiology and immunology 1994;9(1):60-4.
1994: Ingman T; Sorsa T; Lindy O; Koski H; Konttinen Y T
Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients.
Journal of clinical periodontology 1994;21(1):26-31.
1993: Ingman T; Sorsa T; Konttinen Y T; Liede K; Saari H; Lindy O; Suomalainen K
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Oral microbiology and immunology 1993;8(5):298-305.
1993: Ramamurthy N S; Vernillo A T; Greenwald R A; Lee H M; Sorsa T; Golub L M; Rifkin B R
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(10):1247-53.
1993: Lauhio A; Sorsa T; Lindy O; Suomalainen K; Saari H; Golub L M; Konttinen Y T
The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases: comment on the article by Yu et al.
Arthritis and rheumatism 1993;36(9):1335-6.
1993: Saari H; Konttinen Y T; Friman C; Sorsa T
Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate.
Inflammation 1993;17(4):403-15.
1993: Sorsa T; Lindy O; Konttinen Y T; Suomalainen K; Ingman T; Saari H; Halinen S; Lee H M; Golub L M; Hall J
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase.
Antimicrobial agents and chemotherapy 1993;37(3):592-4.
1993: Häyrinen-Immonen R; Sorsa T; Nordström D; Malmström M; Konttinen Y T
Collagenase and stromelysin in recurrent aphthous ulcers (RAU).
International journal of oral and maxillofacial surgery 1993;22(1):46-9.
1993: Ingman T; Sorsa T; Suomalainen K; Halinen S; Lindy O; Lauhio A; Saari H; Konttinen Y T; Golub L M
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Journal of periodontology 1993;64(2):82-8.
1993: Sorsa T; Konttinen Y T; Lindy O; Suomalainen K; Ingman T; Saari H; Halinen S; Lee H M; Golub L M; Hall J
Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase.
Agents and actions. Supplements 1993;39():225-9.
1992: Nordström D C; Konttinen Y T; Sorsa T; Nykanen P; Pettersson T; Santavirta S; Tschopp J
Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis.
Clinical rheumatology 1992;11(4):529-32.
1992: Sorsa T; Ingman T; Suomalainen K; Haapasalo M; Konttinen Y T; Lindy O; Saari H; Uitto V J
Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases.
Infection and immunity 1992;60(11):4491-5.
1992: Sorsa T; Konttinen Y T; Lindy O; Ritchlin C; Saari H; Suomalainen K; Eklund K K; Santavirta S
Collagenase in synovitis of rheumatoid arthritis.
Seminars in arthritis and rheumatism 1992;22(1):44-53.
1992: Konttinen Y T; Hukkanen M; Kemppinen P; Segerberg M; Sorsa T; Malmström M; Rose S; Itescu S; Polak J M
Peptide-containing nerves in labial salivary glands in Sjögren's syndrome.
Arthritis and rheumatism 1992;35(7):815-20.
1992: Häyrinen-Immonen R; Malmström M; Nordström D; Sorsa T; Konttinen Y T
Distribution of adhesion receptors in recurrent oral ulcers.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1992;21(5):199-202.
1992: Suomalainen K; Sorsa T; Ingman T; Lindy O; Golub L M
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
Oral microbiology and immunology 1992;7(2):121-3.
1992: Saari H; Tulamo R M; Konttinen Y T; Sorsa T
Methylprednisolone acetate induced release of cartilage proteoglycans: determination by high performance liquid chromatography.
Annals of the rheumatic diseases 1992;51(2):214-9.
1992: Sorsa T; Ingman T; Suomalainen K; Halinen S; Saari H; Konttinen Y T; Uitto V J; Golub L M
Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus.
Journal of clinical periodontology 1992;19(2):146-9.
1992: Lauhio A; Sorsa T; Lindy O; Suomalainen K; Saari H; Golub L M; Konttinen Y T
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis.
Arthritis and rheumatism 1992;35(2):195-8.
1992: Konttinen Y T; Sorsa T; Hukkanen M; Segerberg M; Kuhlefelt-Sundström M; Malmström M; Polak J M
Topology of innervation of labial salivary glands by protein gene product 9.5 and synaptophysin immunoreactive nerves in patients with Sjögren's syndrome.
The Journal of rheumatology 1992;19(1):30-7.
1992: Suomalainen K; Sorsa T; Golub L M; Ramamurthy N; Lee H M; Uitto V J; Saari H; Konttinen Y T
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Antimicrobial agents and chemotherapy 1992;36(1):227-9.
1992: Sorsa T; Uitto V J; Suomalainen K
Characteristics of human salivary collagenase and its relationship to periodontal diseases.
Matrix (Stuttgart, Germany). Supplement 1992;1():406-7.
1992: Saari H; Sorsa T; Lindy O; Suomalainen K; Halinen S; Konttinen Y T
Reactive oxygen species as regulators of human neutrophil and fibroblast interstitial collagenases.
International journal of tissue reactions 1992;14(3):113-20.
1992: Suomalainen K; Halinen S; Ingman T; Lindy O; Saari H; Konttinen Y T; Golub L M; Sorsa T
Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases.
Drugs under experimental and clinical research 1992;18(3):99-104.
1992: Konttinen Y T; Hukkanen M; Segerberg M; Rees R; Kemppinen P; Sorsa T; Saari H; Polak J M; Santavirta S
Relationship between neuropeptide immunoreactive nerves and inflammatory cells in adjuvant arthritic rats.
Scandinavian journal of rheumatology 1992;21(2):55-9.
1991: Honkanen V; Konttinen Y T; Sorsa T; Hukkanen M; Kemppinen P; Santavirta S; Saari H; Westermarck T
Serum zinc, copper and selenium in rheumatoid arthritis.
Journal of trace elements and electrolytes in health and disease 1991;5(4):261-3.
1991: Konttinen Y T; Lindy O; Suomalainen K; Ritchlin C; Saari H; Vauhkonen M; Lauhio A; Santavirta S; Sorsa T
Substrate specificity and activation mechanisms of collagenase from human rheumatoid synovium.
Matrix (Stuttgart, Germany) 1991;11(6):395-403.
1991: Suomalainen K; Sorsa T; Lindy O; Saari H; Konttinen Y T; Uitto V J
Hypochlorous acid induced activation of human neutrophil and gingival crevicular fluid collagenase can be inhibited by ascorbate.
Scandinavian journal of dental research 1991;99(5):397-405.
1991: Konttinen Y T; Lindy O; Kemppinen P; Saari H; Suomalainen K; Vauhkonen M; Lindy S; Sorsa T
Collagenase reserves in polymorphonuclear neutrophil leukocytes from synovial fluid and peripheral blood of patients with rheumatoid arthritis.
Matrix (Stuttgart, Germany) 1991;11(4):296-301.
1991: Suomalainen K; Sorsa T; Saxén L; Vauhkonen M; Uitto V J
Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis.
Oral microbiology and immunology 1991;6(1):24-9.
1990: Saari H; Suomalainen K; Lindy O; Konttinen Y T; Sorsa T
Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases.
Biochemical and biophysical research communications 1990;171(3):979-87.
1990: Uitto V J; Suomalainen K; Sorsa T
Salivary collagenase. Origin, characteristics and relationship to periodontal health.
Journal of periodontal research 1990;25(3):135-42.
1990: Aaku E; Sorsa T; Wilkström M
Human immunoglobulin G potentiates superoxide production induced by chemotactic peptides and causes degranulation in isolated human neutrophils.
Biochimica et biophysica acta 1990;1052(2):243-7.
1990: Saari H; Sorsa T; Konttinen Y T
Reactive oxygen species and hyaluronate in serum and synovial fluid in arthritis.
International journal of tissue reactions 1990;12(2):81-9.
1990: Sorsa T; Suomalainen K; Uitto V J
The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal diseases.
Archives of oral biology 1990;35 Suppl():193S-196S.
1989: Suomalainen K; Sorsa T; Uitto V J; Vauhkonen M; Lindy S
Characteristics of neutral proteases present in inflamed human gingiva.
Scandinavian journal of dental research 1989;97(4):346-54.
1989: Sorsa T; Konttinen Y T; Lauhio A; Saari H; Suomalainen K; Lindy S
Gold(I) compounds and human neutrophil collagenase.
The Journal of rheumatology 1989;16(7):1009-10.
1989: Uitto V J; Larjava H; Heino J; Sorsa T
A protease of Bacteroides gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator.
Infection and immunity 1989;57(1):213-8.
1989: Sorsa T; Saari H; Konttinen Y T; Suomalainen K; Lindy S; Uitto V J
Non-proteolytic activation of latent human neutrophil collagenase and its role in matrix destruction in periodontal diseases.
International journal of tissue reactions 1989;11(4):153-9.
1989: Sorsa T; Suomalainen K; Konttinen Y T; Saari H T; Lindy S; Uitto V J
Identification of protease(s) capable of further degrading native 3/4- and 1/4-collagen fragments generated by collagenase from native type I collagen in human neutrophils.
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1989;85(1):3-11.
1988: Sorsa T; Uitto V J; Suomalainen K; Vauhkonen M; Lindy S
Comparison of interstitial collagenases from human gingiva, sulcular fluid and polymorphonuclear leukocytes.
Journal of periodontal research 1988;23(6):386-93.
1988: Konttinen Y T; Saari H; Santavirta S; Antti-Poika I; Sorsa T; Nykänen P; Kemppinen P
Synovial fibroblasts.
Scandinavian journal of rheumatology. Supplement 1988;76():95-103.
1987: Sorsa T; Suomalainen K; Turto H; Lindy S
Latent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate, but not by auranofin.
Bioscience reports 1987;7(12):965-8.
1987: Sorsa T; Uitto V J; Suomalainen K; Turto H; Lindy S
A trypsin-like protease from Bacteroides gingivalis: partial purification and characterization.
Journal of periodontal research 1987;22(5):375-80.
1987: Sorsa T; Uitto V J; Suomalainen K; Turto H; Lindy S
Human leukocyte collagenase: recent biochemical findings.
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1987;83(3):111-7.
1987: Lindy S; Sorsa T; Suomalainen K; Turto H
Effects of gold(I) compounds on latent human leucocyte collagenase and gelatinase.
Scandinavian journal of rheumatology. Supplement 1987;67():5-9.
1986: Lindy S; Sorsa T; Suomalainen K; Turto H
Gold sodium thiomalate activates latent human leukocyte collagenase.
FEBS letters 1986;208(1):23-5.
1986: Lindy S; Sorsa T; Suomalainen K; Lauhio A; Turto H
Hyperchromic effect of collagen induced by human collagenase.
European journal of biochemistry / FEBS 1986;156(1):1-4.
1986: Lindy S; Turto H; Sorsa T; Halme J; Lauhio A; Suomalainen K; Uitto V J; Wegelius O
Increased collagenase activity in human rheumatoid meniscus.
Scandinavian journal of rheumatology 1986;15(3):237-42.
1985: Sorsa T; Suomalainen K; Turto H; Lindy S
Partial purification and characterization of latent human leukocyte collagenase.
Medical biology 1985;63(2):66-72.

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