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Eric Sorscher

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Eric J Sorscher; William R Waud; Paula W Allan; Jeong S Hong; William B Parker
In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase.
Nathan S Alexander; Angela Blount; Michael Chestnut; Stephen B Hicks; Frederick A Kebbel; Daniel Skinner; Eric J Sorscher; Shaoyan Zhang; Bradford A Woodworth
Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein.
Bonnie W Ramsey; Ronald C Rubenstein; Pradeep K Singh; Eric J Sorscher; Frank J Accurso; Susan Banks-Schlegel; Richard C Boucher; Garry R Cutting; John F Engelhardt; William B Guggino; Christopher L Karp; Michael R Knowles; Jay K Kolls; John J LiPuma; Susan Lynch; Paul B McCray; Michael Welsh
Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report.

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2012: Eric J Sorscher; William R Waud; Paula W Allan; Jeong S Hong; William B Parker
In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase.
Cancer chemotherapy and pharmacology 2012;70(2):321-9.
2012: Nathan S Alexander; Angela Blount; Michael Chestnut; Stephen B Hicks; Frederick A Kebbel; Daniel Skinner; Eric J Sorscher; Shaoyan Zhang; Bradford A Woodworth
Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein.
The Laryngoscope 2012;122(6):1193-7.
2012: Bonnie W Ramsey; Ronald C Rubenstein; Pradeep K Singh; Eric J Sorscher; Frank J Accurso; Susan Banks-Schlegel; Richard C Boucher; Garry R Cutting; John F Engelhardt; William B Guggino; Christopher L Karp; Michael R Knowles; Jay K Kolls; John J LiPuma; Susan Lynch; Paul B McCray; Michael Welsh
Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report.
American journal of respiratory and critical care medicine 2012;185(8):887-92.
2012: Peter A Sloane; Eric J Sorscher; Li Ping Tang; Andrew Wilhelm; Suresh Shastry; Kyle Backer; Suzanne Byan-Parker; Clifford Courville; Mark T Dransfield; William Grizzle; Elina Levin; Yao Li; Marina Mazur; S Vamsee Raju; Steven M Rowe
A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease.
PloS one 2012;7(6):e39809.
2012: Michelle McClure; John C Kappes; Qun Dai; Marjorie Ray; Xiaoyun Wu; Landon Wilson; Eric J Sorscher; Steven M Rowe; Jeong S Hong; Lawrence J DeLucas; Stephen Barnes
Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications.
Protein engineering, design & selection : PEDS 2012;25(1):7-14.
2011: Louise C Pyle; Aixia Ren; Eric J Sorscher; Graeme B Bolger; John P Clancy; Annette Ehrhardt; Lijuan Fan; Yao Li; Lisa High Mitchell; Anjaparavanda P Naren; Steven M Rowe
Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.
American journal of physiology. Lung cellular and molecular physiology 2011;301(4):L587-97.
2011: Shaoyan Zhang; Christopher Azbell; Nicholas Smith; Eric J Sorscher; Daniel Schuster; Steven M Rowe; Bradford A Woodworth
Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis.
American journal of rhinology & allergy 2011;25(5):307-12.
2011: Angela Blount; Michael Chestnut; Brian Hixon; Daniel Skinner; Eric J Sorscher; Shaoyan Zhang; Bradford A Woodworth
Transepithelial ion transport is suppressed in hypoxic sinonasal epithelium.
The Laryngoscope 2011;121(9):1929-34.
2011: Steven M Rowe; J P Clancy; Eric J Sorscher
A breath of fresh air.
Scientific American 2011;305(2):68-73.
2011: Nathan S Alexander; Neal Hatch; Shaoyan Zhang; Daniel Skinner; James Fortenberry; Eric J Sorscher; Bradford A Woodworth
Resveratrol has salutary effects on mucociliary transport and inflammation in sinonasal epithelium.
The Laryngoscope 2011;121(6):1313-9.
2011: William B Parker; Paula W Allan; William R Waud; J S Hong; Eric J Sorscher
Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase.
Cancer gene therapy 2011;18(6):390-8.
2011: Steven M Sorscher; Aubrey E Hill; Roger Belizaire; Eric J Sorscher
Spontaneous inactivating p53 mutations and the "selfish cell".
Aging 2011;3(3):181.
2011: Kathryn W Peters; Tsukasa Okiyoneda; William E Balch; Ineke Braakman; Jeffrey L Brodsky; William B Guggino; Christopher M Penland; Harvey B Pollard; Eric J Sorscher; William R Skach; Philip J Thomas; Gergely L Lukacs; Raymond A Frizzell
CFTR Folding Consortium: methods available for studies of CFTR folding and correction.
Methods in molecular biology (Clifton, N.J.) 2011;742():335-53.
2010: Viktoria Havasi; Steven M Rowe; Peter N Kolettis; Didem Dayangac; Ahmet Sahin; Ana Grangeia; Filipa Carvalho; Alberto Barros; Mário Sousa; Lluis Bassas; Teresa Casals; Eric J Sorscher
Association of cystic fibrosis genetic modifiers with congenital bilateral absence of the vas deferens.
Fertility and sterility 2010;94(6):2122-7.
2010: Christopher Azbell; Shaoyan Zhang; Daniel Skinner; James Fortenberry; Eric J Sorscher; Bradford A Woodworth
Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2010;143(3):397-404.
2010: Chien-Kuo Tai; Weijun Wang; Y-H Lai; Christopher R Logg; W B Parker; Y-F Li; J S Hong; Eric J Sorscher; Thomas C Chen; Noriyuki Kasahara
Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene.
Cancer gene therapy 2010;17(9):614-23.
2010: S M Rowe; L C Pyle; A Jurkevante; K Varga; J Collawn; P A Sloane; B Woodworth; M Mazur; J Fulton; L Fan; Y Li; J Fortenberry; Eric J Sorscher; J P Clancy
DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers.
Pulmonary pharmacology & therapeutics 2010;23(4):268-78.
2010: Frank W Virgin; Christopher Azbell; Daniel Schuster; Jumin Sunde; Shaoyan Zhang; Eric J Sorscher; Bradford A Woodworth
Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial cultures.
The Laryngoscope 2010;120(7):1465-9.
2010: Frank Virgin; Shaoyan Zhang; Daniel Schuster; Christopher Azbell; James Fortenberry; Eric J Sorscher; Bradford A Woodworth
The bioflavonoid compound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo.
The Laryngoscope 2010;120(5):1051-6.
2010: Darren M Hutt; David Herman; Ana Rodrigues; Sabrina Noel; Joseph M Pilewski; Jeanne Matteson; Ben Hoch; Wendy Kellner; Jeffery W Kelly; Andre Schmidt; Philip J Thomas; Yoshihiro Matsumura; William R Skach; Martina Gentzsch; John R Riordan; Eric J Sorscher; Tsukasa Okiyoneda; John R Yates; Gergely L Lukacs; Raymond A Frizzell; Gerard Manning; Joel M Gottesfeld; William E Balch
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Nature chemical biology 2010;6(1):25-33.
2009: Estelle Cormet-Boyaka; Jeong S Hong; Bakhram K Berdiev; James A Fortenberry; Jessica Rennolds; John P Clancy; Dale J Benos; Prosper N Boyaka; Eric J Sorscher
A truncated CFTR protein rescues endogenous DeltaF508-CFTR and corrects chloride transport in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(11):3743-51.
2009: Noam A Cohen; Shaoyan Zhang; Dawn B Sharp; Edwin Tamashiro; Bei Chen; Eric J Sorscher; Bradford A Woodworth
Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency.
The Laryngoscope 2009;119(11):2269-74.
2009: Shaoyan Zhang; James A Fortenberry; Noam A Cohen; Eric J Sorscher; Bradford A Woodworth
Comparison of vectorial ion transport in primary murine airway and human sinonasal air-liquid interface cultures, models for studies of cystic fibrosis, and other airway diseases.
American journal of rhinology & allergy 2009;23(2):149-52.
2009: Jennifer S Guimbellot; Stephen W Erickson; Tapan Mehta; Hui Wen; Grier P Page; Eric J Sorscher; Jeong S Hong
Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis.
BMC medical genomics 2009;2():15.
2009: Steven M Sorscher; Aubrey Hill; Eric J Sorscher
Evolutionary maintenance of oncogenesis.
Journal of cancer research and clinical oncology 2009;135(1):159-62.
2008: Viktoria Havasi; Steven Keiles; Tina Hambuch; Eric J Sorscher; Anja Kammesheidt
The role of the F508C mutation in congenital bilateral absence of the vas deferens.
Genetics in medicine : official journal of the American College of Medical Genetics 2008;10(12):910-4.
2008: April F White; Marina Mazur; Eric J Sorscher; Kurt R Zinn; Selvarangan Ponnazhagan
Genetic modification of adeno-associated viral vector type 2 capsid enhances gene transfer efficiency in polarized human airway epithelial cells.
Human gene therapy 2008;19(12):1407-14.
2008: Jennifer S Guimbellot; James A Fortenberry; Gene P Siegal; Bryan Moore; Hui Wen; Charles Venglarik; Yiu-Fai Chen; Suzanne Oparil; Eric J Sorscher; Jeong S Hong
Role of oxygen availability in CFTR expression and function.
American journal of respiratory cell and molecular biology 2008;39(5):514-21.
2008: Steven Sorscher; Aubrey E Hill; Eric J Sorscher
Is oncogenesis a normal cellular defense mechanism?
Cancer chemotherapy and pharmacology 2008;62(6):1113.
2008: Steven M Rowe; Patricia L Jackson; Gang Liu; Mathew Hardison; Alessandra Livraghi; G Martin Solomon; D Brent McQuaid; Brett D Noerager; Amit Gaggar; John P Clancy; Wanda O Neal; Eric J Sorscher; Edward Abraham; J Edwin Blalock
Potential role of high-mobility group box 1 in cystic fibrosis airway disease.
American journal of respiratory and critical care medicine 2008;178(8):822-31.
2008: Viktoria Havasi; Casey O Hurst; Travis C Briles; Fan Yang; David G Bains; Daniel J Hassett; Eric J Sorscher
Inhibitory effects of hypertonic saline on P. aeruginosa motility.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2008;7(4):267-9.
2008: György Horváth; Eric J Sorscher
Luminal fluid tonicity regulates airway ciliary beating by altering membrane stretch and intracellular calcium.
Cell motility and the cytoskeleton 2008;65(6):469-75.
2008: Karoly Varga; Rebecca F Goldstein; Asta Jurkuvenaite; Lan Chen; Sadis Matalon; Eric J Sorscher; Zsuzsa Bebok; James F Collawn
Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones.
The Biochemical journal 2008;410(3):555-64.
2007: Bakhrom K Berdiev; Estelle Cormet-Boyaka; Albert Tousson; Yawar J Qadri; Henderika M J Oosterveld-Hut; Jeong S Hong; Patricia A Gonzales; Catherine M Fuller; Eric J Sorscher; Gergely L Lukacs; Dale J Benos
Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer.
The Journal of biological chemistry 2007;282(50):36481-8.
2007: Guy Ungerechts; Christoph Springfeld; Marie Frenzke; Johanna Lampe; Patrick B Johnston; William B Parker; Eric J Sorscher; Roberto Cattaneo
Lymphoma chemovirotherapy: CD20-targeted and convertase-armed measles virus can synergize with fludarabine.
Cancer research 2007;67(22):10939-47.
2007: Guy Ungerechts; Christoph Springfeld; Marie Frenzke; Johanna Lampe; William B Parker; Eric J Sorscher; Roberto Cattaneo
An immunocompetent murine model for oncolysis with an armed and targeted measles virus.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):1991-7.
2007: Steven M Rowe; Karoly Varga; Andras Rab; Zsuzsa Bebok; Kevin Byram; Yao Li; Eric J Sorscher; John P Clancy
Restoration of W1282X CFTR activity by enhanced expression.
American journal of respiratory cell and molecular biology 2007;37(3):347-56.
2007: Eleanor Bates; Stacey Miller; Mariah Alexander; Marina Mazur; James A Fortenberry; Zsuzsa Bebok; Eric J Sorscher; Steven M Rowe
Bioelectric effects of quinine on polarized airway epithelial cells.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2007;6(5):351-9.
2006: Xuefeng Su; Qingnan Li; Kedar Shrestha; Estelle Cormet-Boyaka; Lan Chen; Peter R Smith; Eric J Sorscher; Dale J Benos; Sadis Matalon; Hong-Long Ji
Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry 2006;281(48):36960-8.
2006: Aubrey E Hill; Eric J Sorscher
The non-random distribution of intronless human genes across molecular function categories.
FEBS letters 2006;580(18):4303-5.
2006: Ming Du; Kim M Keeling; Liming Fan; Xiaoli Liu; Timea Kovaçs; Eric J Sorscher; David M Bedwell
Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model.
Journal of molecular medicine (Berlin, Germany) 2006;84(7):573-82.
2006: Eric J Sorscher; J Harris; M Alexander; A Rottgers; K Hardy; Selvarangan Ponnazhagan; James F Collawn; James B McClintock; Charles D Amsler; A Webster; Joseph A Maddry; Bill J Baker; Jeong S Hong
Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening.
Gene therapy 2006;13(9):781-8.
2006: Ian C Davis; Eduardo R Lazarowski; Judy M Hickman-Davis; James A Fortenberry; Fu-Ping Chen; Xiaodong Zhao; Eric J Sorscher; Lee M Graves; Wayne M Sullender; Sadis Matalon
Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus.
American journal of respiratory and critical care medicine 2006;173(6):673-82.
2006: Asta Jurkuvenaite; Karoly Varga; Krzysztof Nowotarski; Kevin L Kirk; Eric J Sorscher; Yao Li; John P Clancy; Zsuzsa Bebok; James F Collawn
Mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis.
The Journal of biological chemistry 2006;281(6):3329-34.
2006: Aubrey E Hill; Jeong S Hong; Hui Wen; LiHong Teng; David T McPherson; Sylvia A McPherson; Dana Levasseur; Eric J Sorscher
Micro-RNA-like effects of complete intronic sequences.
Frontiers in bioscience : a journal and virtual library 2006;11():1998-2006.
2005: Zsuzsa Bebok; James F Collawn; John Wakefield; William Parker; Yao Li; Karoly Varga; Eric J Sorscher; John P Clancy
Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers.
The Journal of physiology 2005;569(Pt 2):601-15.
2005: Steven M Rowe; Stacey Miller; Eric J Sorscher
Cystic fibrosis.
The New England journal of medicine 2005;352(19):1992-2001.
2005: Suman Bharara; Eric J Sorscher; G Yancey Gillespie; J Russell Lindsey; Jeong S Hong; Kimberly V Curlee; Paula W Allan; Vijayakrishna K Gadi; Sherrie A Alexander; John A Secrist; William B Parker; William R Waud
Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.
Human gene therapy 2005;16(3):339-47.
2005: Yang Zhang; William B Parker; Eric J Sorscher; Steven E Ealick
PNP anticancer gene therapy.
Current topics in medicinal chemistry 2005;5(13):1259-74.
2005: A V Silamkoti; Paula W Allan; Abdalla E A Hassan; Anita T Fowler; Eric J Sorscher; William B Parker; John A Secrist
Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):881-5.
2005: William B Parker; Paula W Allan; Steven E Ealick; Eric J Sorscher; Abdalla E A Hassan; A V Silamkoti; Anita T Fowler; William R Waud; John A Secrist
Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):387-92.
2005: Meena Kishore Sakharkar; Pandjassarame Kangueane; Bagavathi S Perumal; Vincent T K Chow; Eric J Sorscher; Kishore Sakharkar; Aubrey Hill
Human genome -- from pieces to patterns.
Frontiers in bioscience : a journal and virtual library 2005;10():2576-84.
2004: Jeong S Hong; William R Waud; Dana Levasseur; Tim M Townes; Hui Wen; Sylvia A McPherson; Bryan A Moore; Zsuzsa Bebok; Paula W Allan; John A Secrist; William B Parker; Eric J Sorscher
Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene.
Cancer research 2004;64(18):6610-5.
2004: Ceinwen M Harris; Filipa Mendes; Anca Dragomir; I J M Doull; Isabel Carvalho-Oliveira; Zsuzsa Bebok; John P Clancy; Valerie Eubanks; Eric J Sorscher; Godfried M Roomans; Margarida D Amaral; Margaret A McPherson; Deborah Penque; Robert L Dormer
Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():43-8.
2004: Karen Hentchel-Franks; David Lozano; Valerie Eubanks-Tarn; Bryan Cobb; Lijuan Fan; Robert A Oster; Eric J Sorscher; John P Clancy
Activation of airway cl- secretion in human subjects by adenosine.
American journal of respiratory cell and molecular biology 2004;31(2):140-6.
2004: Aubrey Hill; Eric J Sorscher
Common structural patterns in human genes.
Bioinformatics (Oxford, England) 2004;20(10):1632-5.
2004: Jason K Burrus; William D Matheson; Jeong S Hong; Eric J Sorscher; Daniel F Balkovetz
Hepatocyte growth factor stimulates adenoviral-mediated gene transfer across the apical membrane of epithelial cells.
The journal of gene medicine 2004;6(6):624-30.
2004: Karoly Varga; Asta Jurkuvenaite; John Wakefield; Jeong S Hong; Jennifer S Guimbellot; Charles J Venglarik; Ashutosh Niraj; Marina Mazur; Eric J Sorscher; James F Collawn; Zsuzsa Bebök
Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines.
The Journal of biological chemistry 2004;279(21):22578-84.
2004: Ákos Zsembery; James A Fortenberry; Lihua Liang; Zsuzsa Bebok; Torry A Tucker; Amanda T Boyce; Gavin M Braunstein; Elisabeth Welty; Phillip Darwin Bell; Eric J Sorscher; John P Clancy; Erik M Schwiebert
Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry.
The Journal of biological chemistry 2004;279(11):10720-9.
2004: Kimberly V Curlee; William B Parker; Eric J Sorscher
Tumor sensitization to purine analogs by E. coli PNP.
Methods in molecular medicine 2004;90():223-45.
2003: Eric M Bennett; Ruchi Anand; Paula W Allan; Abdalla E A Hassan; Jeong S Hong; Dana Levasseur; David T McPherson; William B Parker; John A Secrist; Eric J Sorscher; Tim M Townes; William R Waud; Steven E Ealick
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chemistry & biology 2003;10(12):1173-81.
2003: Julie R Jones; Erik M Schwiebert; Michael D DuVall; Charles J Venglarik; Hui Wen; Timea Kovacs; Marina Mazur; John P Clancy; Gavin M Braunstein; Eleanor Bates; Heather Greer; Joseph A Maddry; Eric J Sorscher
Activation of chloride secretion in cystic fibrosis cells and tissues by the substituted imidazole SRI 2931.
Biochemistry 2003;42(45):13241-9.
2003: Bryan Cobb; Lijuan Fan; Timea Kovacs; Eric J Sorscher; John P Clancy
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.
American journal of respiratory cell and molecular biology 2003;29(3 Pt 1):410-8.
2003: Kimberly V Curlee; Jeong S Hong; John P Clancy; Scott A King; Eric Hunter; Bakhrom K Berdiev; Dale J Benos; Maja A Sommerfelt; Eric J Sorscher; Michael Sakalian
Membrane transplantation to correct integral membrane protein defects.
Journal of molecular medicine (Berlin, Germany) 2003;81(8):511-20.
2003: Vijayakrishna K Gadi; Sherrie D Alexander; William R Waud; Paula W Allan; William B Parker; Eric J Sorscher
A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1280-4.
2003: Anjaparavanda P Naren; Bryan Cobb; Chunying Li; Koushik Roy; David Nelson; Ghanshyam D Heda; Jie Liao; Kevin L Kirk; Eric J Sorscher; John Hanrahan; John P Clancy
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):342-6.
2003: William B Parker; Paula W Allan; Abdalla E A Hassan; John A Secrist; Eric J Sorscher; William R Waud
Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase.
Cancer gene therapy 2003;10(1):23-9.
2002: Krisztina Peter; Karoly Varga; Zsuzsa Bebok; Carmel M McNicholas-Bevensee; Lisa M Schwiebert; Eric J Sorscher; Erik M Schwiebert; James F Collawn
Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression.
The Journal of biological chemistry 2002;277(51):49952-7.
2002: Zsuzsa Bebok; Karoly Varga; James K Hicks; Charles J Venglarik; Timea Kovacs; Lan Chen; Karin M Hardiman; James F Collawn; Eric J Sorscher; Sadis Matalon
Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia.
The Journal of biological chemistry 2002;277(45):43041-9.
2002: Ofer Eidelman; Shoshana BarNoy; Michal Razin; Jiang Zhang; Peter McPhie; George Lee; Zhen Huang; Eric J Sorscher; Harvey B Pollard
Role for phospholipid interactions in the trafficking defect of Delta F508-CFTR.
Biochemistry 2002;41(37):11161-70.
2002: Ming Du; Julie R Jones; Jessica Lanier; Kim M Keeling; J Russell Lindsey; Albert Tousson; Zsuzsa Bebök; Jeffrey A Whitsett; Chitta R Dey; William H Colledge; Martin J Evans; Eric J Sorscher; David M Bedwell
Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.
Journal of molecular medicine (Berlin, Germany) 2002;80(9):595-604.
2002: Josie L Falany; Heather Greer; Timea Kovacs; Eric J Sorscher; Charles N Falany
Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis.
The Biochemical journal 2002;364(Pt 1):115-20.
2002: Valerie Eubanks; Nicki Koppersmith; Nancy Wooldridge; John P Clancy; Raymond Lyrene; Ramin B Arani; Jeanette Lee; Lyle Moldawer; Joy Atchison; Eric J Sorscher; Christopher M Makris
Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis.
The Journal of pediatrics 2002;140(4):439-44.
2002: Carpantato Myles; Eric J Sorscher; Sadis Matalon
Enhancement of adenovirus-mediated gene transfer in lungs and epithelial cells by EGTA.
Chest 2002;121(3 Suppl):35S.
2002: Kimberly V Curlee; Eric J Sorscher
Design of gene therapy clinical trials in CF patients.
Methods in molecular medicine 2002;70():575-84.
2002: Bryan Cobb; F Ruiz; C M King; James D Fortenberry; Heather Greer; Timea Kovacs; Eric J Sorscher; John P Clancy
A(2) adenosine receptors regulate CFTR through PKA and PLA(2).
American journal of physiology. Lung cellular and molecular physiology 2002;282(1):L12-25.
2001: L Gao; James R Yankaskas; Catherine M Fuller; Eric J Sorscher; Sadis Matalon; Henry Jay Forman; Charles J Venglarik
Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2001;281(5):L1123-9.
2001: John P Clancy; Zsuzsa Bebök; F Ruiz; C King; J Jones; L Walker; Heather Greer; J Hong; L Wing; M Macaluso; Raymond Lyrene; Eric J Sorscher; David M Bedwell
Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis.
American journal of respiratory and critical care medicine 2001;163(7):1683-92.
2001: F E Ruiz; John P Clancy; Michael A Perricone; Zsuzsa Bebok; Jeong S Hong; Seng Cheng; DP Meeker; K Randall Young; R A Schoumacher; Mark R Weatherly; L Wing; James E Morris; L Sindel; M Rosenberg; Frederik W van Ginkel; Jerry R McGhee; D Kelly; Raymond Lyrene; Eric J Sorscher
A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis.
Human gene therapy 2001;12(7):751-61.
2000: Vijayakrishna K Gadi; S D Alexander; Jeffrey E Kudlow; Paula W Allan; William B Parker; Eric J Sorscher
In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells.
Gene therapy 2000;7(20):1738-43.
2000: Scott A King; Eric J Sorscher
R-domain interactions with distal regions of CFTR lead to phosphorylation and activation.
Biochemistry 2000;39(32):9868-75.
1999: Stephen T Ballard; Laura Trout; Zsuzsa Bebök; Eric J Sorscher; AD Crews
CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands.
The American journal of physiology 1999;277(4 Pt 1):L694-9.
1999: Amanda L Taylor; Lisa M Schwiebert; J J Smith; C King; J R Jones; Eric J Sorscher; Erik M Schwiebert
Epithelial P2X purinergic receptor channel expression and function.
The Journal of clinical investigation 1999;104(7):875-84.
1999: Rafael Garcia-Mata; Zsuzsa Bebök; Eric J Sorscher; Elizabeth Sztul
Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera.
The Journal of cell biology 1999;146(6):1239-54.
1999: Vijayakrishna K Gadi; Nianxiang Zou; JS Liu; Seng Cheng; Thomas R Broker; Eric J Sorscher; Louise T Chow
Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells.
American journal of respiratory cell and molecular biology 1999;20(5):1001-6.
1999: John A Secrist; William B Parker; Paula W Allan; LL Bennett; William R Waud; J W Truss; Anita T Fowler; John A Montgomery; Steven E Ealick; A H Wells; G Yancey Gillespie; Vijayakrishna K Gadi; Eric J Sorscher
Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.
Nucleosides & nucleotides 1999;18(4-5):745-57.
1999: Geoffrey C Meacham; Z Lu; S King; Eric J Sorscher; A Tousson; Doug Cyr
The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis.
The EMBO journal 1999;18(6):1492-505.
1999: John P Clancy; F E Ruiz; Eric J Sorscher
Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway.
The American journal of physiology 1999;276(2 Pt 1):C361-9.
1998: Zsuzsa Bebök; Christopher Mazzochi; Scott A King; Jeong S Hong; Eric J Sorscher
The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary.
The Journal of biological chemistry 1998;273(45):29873-8.
1998: John P Clancy; Jeong S Hong; Zsuzsa Bebök; Scott A King; S Demolombe; David M Bedwell; Eric J Sorscher
Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain 1 (NBD-1) and CFTR truncated within NBD-1 target to the epithelial plasma membrane and increase anion permeability.
Biochemistry 1998;37(43):15222-30.
1998: Zsuzsa Bebök; Charles J Venglarik; Z Pánczél; T Jilling; Kevin L Kirk; Eric J Sorscher
Activation of DeltaF508 CFTR in an epithelial monolayer.
The American journal of physiology 1998;275(2 Pt 1):C599-607.
1998: B W Hughes; Scott A King; Paula W Allan; William B Parker; Eric J Sorscher
Cell to cell contact is not required for bystander cell killing by Escherichia coli purine nucleoside phosphorylase.
The Journal of biological chemistry 1998;273(4):2322-8.
1998: Scott A King; Eric J Sorscher
Recombinant synthesis of cystic fibrosis transmembrane conductance regulator and functional nucleotide-binding domains.
Methods in enzymology 1998;292():686-97.
1997: David M Bedwell; A Kaenjak; Dale J Benos; Zsuzsa Bebok; James K Bubien; J Hong; Albert Tousson; John P Clancy; Eric J Sorscher
Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line.
Nature medicine 1997;3(11):1280-4.
1997: John P Clancy; Zsuzsa Bebök; Eric J Sorscher
Purification, characterization, and expression of CFTR nucleotide-binding domains.
Journal of bioenergetics and biomembranes 1997;29(5):475-82.
1997: William B Parker; Scott A King; Paula W Allan; LL Bennett; John A Secrist; John A Montgomery; K S Gilbert; William R Waud; A H Wells; G Yancey Gillespie; Eric J Sorscher
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
Human gene therapy 1997;8(14):1637-44.
1997: Frederik W van Ginkel; Jerry R McGhee; Cunren Liu; Jerry Simecka; Masato Yamamoto; R A Frizzell; Eric J Sorscher; Hiroshi Kiyono; David W Pascual
Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):685-93.
1997: B E Cohen; G Lee; Kenneth Alan Jacobson; YC Kim; Z Huang; Eric J Sorscher; Harvey B Pollard
8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator.
Biochemistry 1997;36(21):6455-61.
1997: I Y Haddad; Eric J Sorscher; Robert I Garver; J Hong; E Tzeng; Sadis Matalon
Modulation of adenovirus-mediated gene transfer by nitric oxide.
American journal of respiratory cell and molecular biology 1997;16(5):501-9.
1997: L C Walker; Charles J Venglarik; G Aubin; Mark R Weatherly; Nael A McCarty; B Lesnick; F Ruiz; John P Clancy; Eric J Sorscher
Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR.
American journal of respiratory and critical care medicine 1997;155(5):1684-9.
1996: Zsuzsa Bebök; A M Abai; Jian-Yun Dong; Scott A King; Kevin L Kirk; G Berta; B W Hughes; Andrew Kraft; S W Burgess; W Shaw; P L Felgner; Eric J Sorscher
Efficiency of plasmid delivery and expression after lipid-mediated gene transfer to human cells in vitro.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1462-9.
1996: Sophie Demolombe; Isabelle Baro; Z Bebok; John P Clancy; Eric J Sorscher; A Thomas-Soumarmon; A Pavirani; D Escande
A method for the rapid detection of recombinant CFTR during gene therapy in cystic fibrosis.
Gene therapy 1996;3(8):685-94.
1996: L Walker; Markku Kulomaa; Z Bebok; William B Parker; P Allan; J Logan; Z Huang; R C Reynolds; S King; Eric J Sorscher
Development of drug targeting based on recombinant expression of the chicken avidin gene.
Journal of drug targeting 1996;4(1):41-9.
1995: Biljana Jovov; Iskander I Ismailov; Bakhrom K Berdiev; Catherine M Fuller; Eric J Sorscher; John R Dedman; Marcia A Kaetzel; Dale J Benos
Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels.
The Journal of biological chemistry 1995;270(49):29194-200.
1995: B W Hughes; A H Wells; Z Bebok; Vijayakrishna K Gadi; Robert I Garver; William B Parker; Eric J Sorscher
Bystander killing of melanoma cells using the human tyrosinase promoter to express the Escherichia coli purine nucleoside phosphorylase gene.
Cancer research 1995;55(15):3339-45.
1995: Edward Hasty; Wanda O Neal; K Q Liu; Andrew P Morris; Z Bebok; G B Shumyatsky; T Jilling; Eric J Sorscher; Allan Bradley; Arthur L Beaudet
Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene.
Somatic cell and molecular genetics 1995;21(3):177-87.
1995: Eric J Sorscher; Maja A Sommerfelt
Purification of recombinant protein derived from the baculovirus expression system using glutathione affinity agarose.
Methods in molecular biology (Clifton, N.J.) 1995;39():337-48.
1994: Eric J Sorscher; James J Logan; Raymond A Frizzell; Raymond K Lyrene; Zsuzsa Bebok; Jian-Yun Dong; MD DuVall; P L Felgner; Sadis Matalon; Lynn Walker; Brian J Wiatrak
Informed consent to participate in a research study -- gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway.
Human gene therapy 1994;5(10):1271-7.
1994: Eric J Sorscher; J J Logan; R A Frizzell; R K Lyrene; Z Bebok; Jian-Yun Dong; MD DuVall; P L Felgner; S Matalon; L Walker
Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway.
Human gene therapy 1994;5(10):1259-77.
1994: Eric J Sorscher; S Peng; Z Bebok; Paula W Allan; LL Bennett; William B Parker
Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.
Gene therapy 1994;1(4):233-8.
1994: J Logan; D Hiestand; P Daram; Z Huang; D D Muccio; J Hartman; BE Haley; W J Cook; Eric J Sorscher
Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding.
The Journal of clinical investigation 1994;94(1):228-36.
1994: E Weber; G Berta; Albert Tousson; Patricia L St John; M W Green; U Gopalokrishnan; T Jilling; Eric J Sorscher; T S Elton; Dale R Abrahamson
Expression and polarized targeting of a rab3 isoform in epithelial cells.
The Journal of cell biology 1994;125(3):583-94.
1994: Maja A Sommerfelt; Eric J Sorscher
Use of fluorescence-activated cell sorting for rapid isolation of insect cells harboring recombinant baculovirus.
Methods in cell biology 1994;42 Pt B():563-74.
1994: Robert I Garver; K T Goldsmith; B Rodu; P C Hu; Eric J Sorscher; David T Curiel
Strategy for achieving selective killing of carcinomas.
Gene therapy 1994;1(1):46-50.
1993: S Peng; Maja A Sommerfelt; J Logan; Z Huang; T Jilling; K Kirk; Eric Hunter; Eric J Sorscher
One-step affinity isolation of recombinant protein using the baculovirus/insect cell expression system.
Protein expression and purification 1993;4(2):95-100.
1993: S Peng; Maja A Sommerfelt; G Berta; A K Berry; Kevin L Kirk; Eric Hunter; Eric J Sorscher
Rapid purification of recombinant baculovirus using fluorescence-activated cell sorting.
BioTechniques 1993;14(2):274-7.
1992: Neil A Bradbury; T Jilling; G Berta; Eric J Sorscher; Robert J Bridges; Kevin L Kirk
Regulation of plasma membrane recycling by CFTR.
Science (New York, N.Y.) 1992;256(5056):530-2.
1992: J Hartman; P Daram; R A Frizzell; T Rado; Dale J Benos; Eric J Sorscher
Affinity purification of insoluble recombinant fusion proteins containing glutathione-S-transferase.
Biotechnology and bioengineering 1992;39(8):828-32.
1992: J Hartman; Z Huang; T A Rado; S Peng; T Jilling; D D Muccio; Eric J Sorscher
Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene product.
The Journal of biological chemistry 1992;267(10):6455-8.
1992: Nelson Arispe; Eduardo Rojas; J Hartman; Eric J Sorscher; Harvey B Pollard
Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1539-43.
1992: Eric J Sorscher; Catherine M Fuller; Robert J Bridges; Albert Tousson; Richard B Marchase; B R Brinkley; R A Frizzell; Dale J Benos
Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptide.
The American journal of physiology 1992;262(1 Pt 1):C136-47.
1991: Eric J Sorscher; Kevin L Kirk; M L Weaver; T Jilling; J Edwin Blalock; R D LeBoeuf
Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7759-62.
1991: Eric J Sorscher; Z Huang
Diagnosis of genetic disease by primer-specified restriction map modification, with application to cystic fibrosis and retinitis pigmentosa.
Lancet 1991;337(8750):1115-8.
1989: Albert Tousson; C D Alley; Eric J Sorscher; Bill R Brinkley; Dale J Benos
Immunochemical localization of amiloride-sensitive sodium channels in sodium-transporting epithelia.
Journal of cell science 1989;93 ( Pt 2)():349-62.
1989: Dennis Brown; Eric J Sorscher; Dennis A Ausiello; Dale J Benos
Immunocytochemical localization of Na+ channels in rat kidney medulla.
The American journal of physiology 1989;256(2 Pt 2):F366-9.
1988: Eric J Sorscher; M A Accavitti; DA Keeton; E Steadman; R A Frizzell; Dale J Benos
Antibodies against purified epithelial sodium channel protein from bovine renal papilla.
The American journal of physiology 1988;255(6 Pt 1):C835-43.
1988: S Sariban-Sohraby; Eric J Sorscher; Barry M Brenner; Dale J Benos
Phosphorylation of a single subunit of the epithelial Na+ channel protein following vasopressin treatment of A6 cells.
The Journal of biological chemistry 1988;263(27):13875-9.
1982: Eric J Sorscher; J L Breslow
Cystic fibrosis: a disorder of calcium-stimulated secretion and transepithelial sodium transport?
Lancet 1982;1(8268):368-70.