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Eddy Sotelo

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Jhonny Azuaje; Alberto Coelho; Abdelaziz El Maatougui; Franco Fernández; José M Pérez-Rubio; Eddy Sotelo
Multicomponent Assembly of Diverse Pyrazin-2(1H)-one Chemotypes.
Vicente Yaziji; José Brea; María Isabel Cadavid; Alberto Coelho; Abdelaziz El Maatougui; Xerardo García-Mera; Hugo Gutierrez de teran; M Isabel Loza; David Rodríguez; Eddy Sotelo
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.
Abdelaziz El Maatougui; Vicente Yaziji; Carmen López; Matilde Yañez; Jhonny Azuaje; Ernesto Cano; Carlos Carbajales; Alberto Coelho; Eddy Sotelo
Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors.

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All Publications

2013: Jhonny Azuaje; Alberto Coelho; Abdelaziz El Maatougui; Franco Fernández; José M Pérez-Rubio; Eddy Sotelo
Multicomponent Assembly of Diverse Pyrazin-2(1H)-one Chemotypes.
The Journal of organic chemistry 2013;78(9):4402-9.
2013: Vicente Yaziji; José Brea; María Isabel Cadavid; Alberto Coelho; Abdelaziz El Maatougui; Xerardo García-Mera; Hugo Gutierrez de teran; M Isabel Loza; David Rodríguez; Eddy Sotelo
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.
European journal of medicinal chemistry 2013;59():235-42.
2012: Abdelaziz El Maatougui; Vicente Yaziji; Carmen López; Matilde Yañez; Jhonny Azuaje; Ernesto Cano; Carlos Carbajales; Alberto Coelho; Eddy Sotelo
Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors.
Combinatorial chemistry & high throughput screening 2012;15(7):551-4.
2011: Vicente Yaziji; David Rodríguez; Hugo Gutierrez de teran; Alberto Coelho; Olga Caamaño; Xerardo García-Mera; José Brea; M Isabel Loza; María Isabel Cadavid; Eddy Sotelo
Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2011;54(2):457-71.
2011: Abel Crespo; Alberto Coelho; Paula M Diz; Franco Fernández; Hector Novoa de Armas; Eddy Sotelo
Convergent assembly of structurally diverse quinazolines.
Organic & biomolecular chemistry 2011;9(2):351-7.
2011: Jhonny Azuaje; Alberto Coelho; Abdelaziz El Maatougui; José Manuel Blanco; Eddy Sotelo
Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger.
ACS combinatorial science 2011;13(1):89-95.
2011: Abdelaziz El Maatougui; Jhonny Azuaje; Eddy Sotelo; Olga Caamaño; Alberto Coelho
Silica-supported aluminum chloride-assisted solution phase synthesis of pyridazinone-based antiplatelet agents.
ACS combinatorial science 2011;13(1):7-12.
2009: Vicente Yaziji; Alberto Coelho; Abdelaziz El Maatougui; José Brea; M Isabel Loza; Xerardo Garcia-Mera; Eddy Sotelo
Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists.
Journal of combinatorial chemistry 2009;11(4):519-22.
2008: Angela Stefanachi; Jose Manuel Brea; María Isabel Cadavid; Nuria B Centeno; Cristina Esteve; M Isabel Loza; Ana Martinez; Rosa Nieto; Enrique Raviña; Ferran Sanz; Victor Segarra; Eddy Sotelo; Bernat Vidal; Angelo Carotti
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.
Bioorganic & medicinal chemistry 2008;16(6):2852-69.
2008: Ana Martínez; Hugo Gutierrez de teran; José Brea; Enrique Raviña; M Isabel Loza; María Isabel Cadavid; Ferran Sanz; Bernat Vidal; Victor Segarra; Eddy Sotelo
Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.
Bioorganic & medicinal chemistry 2008;16(4):2103-13.
2008: Caroline Meyers; Matilde Yáñez; Abdelaziz Elmaatougi; Tom Verhelst; Alberto Coelho; Matilde Yañez; Guy Lemière; Xerardo García-Mera; Reyes Laguna; Ernesto Cano; Bert U W Maes; Eddy Sotelo
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.
Bioorganic & medicinal chemistry letters 2008;18(2):793-7.
2007: Alberto Coelho; Enrique Raviña; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Eddy Sotelo
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity.
Journal of medicinal chemistry 2007;50(26):6476-84.
2006: J Fernando Padín; Miguel A Rodríguez; Eduardo Domínguez; Iria G. Dopeso Reyes; Montserrat Buceta; Ernesto Cano; Eddy Sotelo; José Brea; Hector Caruncho; M Isabel Cadavid; Marian Castro; M Isabel Loza
Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells.
Neuropharmacology 2006;51(4):923-32.
2006: Alberto Coelho; Eddy Sotelo
Straightforward entry to libraries of diversely substituted azinones by a consecutive aza-Michael/palladium-catalyzed functionalization strategy.
Journal of combinatorial chemistry 2006;8(3):388-400.
2006: Abel Crespo; Caroline Meyers; Alberto Coelho; Matilde Yáñez; Matilde Yañez; Eddy Sotelo; Bert U W Maes; Reyes Laguna; Ernesto Cano; Guy Lemière; Enrique Raviña
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.
Bioorganic & medicinal chemistry letters 2006;16(4):1080-3.
2006: Angelo Carotti; María Isabel Cadavid; Nuria B Centeno; Cristina Esteve; M Isabel Loza; Ana Martinez; Rosa Nieto; Enrique Raviña; Ferran Sanz; Victor Segarra; Eddy Sotelo; Angela Stefanachi; Bernat Vidal
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.
Journal of medicinal chemistry 2006;49(1):282-99.
2006: Alberto Coelho; Eddy Sotelo
Straightforward three-component palladium-catalysed synthesis of pyridazin-3(2H)-one libraries.
Combinatorial chemistry & high throughput screening 2006;9(1):15-9.
2005: Alberto Coelho; Eddy Sotelo
Expanding the chemical diversity of azinone libraries by a consecutive alkylation/palladium-catalyzed functionalization strategy.
Journal of combinatorial chemistry 2005;7(4):526-9.
2004: Angelo Carotti; Angela Stefanachi; Enrique Raviña; Eddy Sotelo; M Isabel Loza; María Isabel Cadavid; Nuria B Centeno; Orazio Nicolotti
8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.
European journal of medicinal chemistry 2004;39(10):879-87.
2004: Alberto Coelho; Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Enrique Raviña
Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.
Bioorganic & medicinal chemistry letters 2004;14(2):321-4.
2004: Eddy Sotelo
Pyridazines. Part 37: Facile solution phase combinatorial synthesis of highly substituted pyridazin-3-ones.
Molecular diversity 2004;8(2):159-63.
2003: Rosa Maria Nieto; Alberto Coelho; Ana Martínez; Angela Stefanachi; Eddy Sotelo; Enrique Raviña
Synthesis of 1-substituted-6-methyluracils.
Chemical & pharmaceutical bulletin 2003;51(9):1025-8.
2003: Eddy Sotelo; Alberto Coelho; Enrique Raviña
Pyridazine derivatives 32: Stille-based approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones.
Chemical & pharmaceutical bulletin 2003;51(4):427-30.
2002: Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Enrique Raviña
Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.
Chemical & pharmaceutical bulletin 2002;50(12):1574-7.
2002: Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Vicente Terrades; Reyes Laguna; Ernesto Cano; Enrique Raviña
Pyridazines. Part XXIX: synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions.
Bioorganic & medicinal chemistry 2002;10(9):2873-82.
2002: Eddy Sotelo; Matilde Yañez; Matilde Yáñez; Reyes Laguna; Ernesto Cano; José Brea; Enrique Raviña
Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(12):1575-7.
1997: Reyes Laguna; B Rodriguez-Liñares; Ernesto Cano; I Estevez; Enrique Raviña; Eddy Sotelo
Pyridazines. XIII. Synthesis of 6-aryl-5-oxygenated substituted-3(2H)-pyridazinones and evaluation as platelet aggregation inhibitors.
Chemical & pharmaceutical bulletin 1997;45(7):1151-5.