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Georgia Sotiropoulou

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Maria Chimonidou; Vasilis Georgoulias; Nikolaos Malamos; Costas Sfikas; Georgia Sotiropoulou; Areti Strati; Alexandra Tzitzira; Evi S Lianidou
CST6 promoter methylation in circulating cell-free DNA of breast cancer patients.
Georgia Sotiropoulou; Georgios Pampalakis
Targeting the kallikrein-related peptidases for drug development.
Maria Kapasa; Myrto Kostadima; Georgia Sotiropoulou; Dimitrios Vlachakis; Sophia Kossida
Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation.

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All Publications

2013: Maria Chimonidou; Vasilis Georgoulias; Nikolaos Malamos; Costas Sfikas; Georgia Sotiropoulou; Areti Strati; Alexandra Tzitzira; Evi S Lianidou
CST6 promoter methylation in circulating cell-free DNA of breast cancer patients.
Clinical biochemistry 2013;46(3):235-40.
2012: Georgia Sotiropoulou; Georgios Pampalakis
Targeting the kallikrein-related peptidases for drug development.
Trends in pharmacological sciences 2012;33(12):623-34.
2012: Maria Kapasa; Myrto Kostadima; Georgia Sotiropoulou; Dimitrios Vlachakis; Sophia Kossida
Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation.
Genomics 2012;100(4):212-21.
2012: Steve Arnold; Celia Cortez; Kalliopi Kantiotou; Sotiris Missailidis; Georgios Pampalakis; Dilson Silva; Georgia Sotiropoulou
One round of SELEX for the generation of DNA aptamers directed against KLK6.
Biological chemistry 2012;393(5):343-53.
2012: Georgia Sotiropoulou; Gregory P Evangelatos; Georgios Pampalakis; Evangelia Prosnikli; Evangelia Livaniou
Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6.
Chemistry Central journal 2012;6(1):148.
2011: Anastasios D Papanastasiou; Dionyssios Katsaros; Georgios Pampalakis; Georgia Sotiropoulou
Netrin-1 overexpression is predictive of ovarian malignancies.
Oncotarget 2011;2(5):363-7.
2010: Georgia Sotiropoulou; Georgios Pampalakis
Kallikrein-related peptidases: bridges between immune functions and extracellular matrix degradation.
Biological chemistry 2010;391(4):321-31.
2010: Georgios Pampalakis; Eleftherios P Diamandis; Dionyssios Katsaros; Georgia Sotiropoulou
Down-regulation of dicer expression in ovarian cancer tissues.
Clinical biochemistry 2010;43(3):324-7.
2010: Athanasia Pavlopoulou; Georgios Pampalakis; Ioannis Michalopoulos; Georgia Sotiropoulou
Evolutionary history of tissue kallikreins.
PloS one 2010;5(11):e13781.
2009: Georgia Sotiropoulou; Georgios Pampalakis; Eleftherios P Diamandis
Functional roles of human kallikrein-related peptidases.
The Journal of biological chemistry 2009;284(48):32989-94.
2009: Georgia Sotiropoulou; Georgios Pampalakis; Evi Lianidou; Zissimos Mourelatos
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell.
RNA (New York, N.Y.) 2009;15(8):1443-61.
2009: Georgios Pampalakis; Evangelia Prosnikli; Theodora Agalioti; Antonia Vlahou; Vassilis Zoumpourlis; Georgia Sotiropoulou
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition.
Cancer research 2009;69(9):3779-87.
2008: Georgios Pampalakis; Andreas Scorilas; Georgia Sotiropoulou
Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer.
Clinical biochemistry 2008;41(7-8):591-7.
2008: Georgios Pampalakis; Maria Arampatzidou; Grigoris Amoutzias; Sofia Kossida; Georgia Sotiropoulou
Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates.
Computational biology and chemistry 2008;32(2):111-21.
2007: Carla A Borgoño; Julie-Ann Gavigan; Juliano Alves; Ben Bowles; Jennifer L Harris; Georgia Sotiropoulou; Eleftherios P Diamandis
Defining the extended substrate specificity of kallikrein 1-related peptidases.
Biological chemistry 2007;388(11):1215-25.
2007: Georgios Pampalakis; Georgia Sotiropoulou
Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer.
Biochimica et biophysica acta 2007;1776(1):22-31.
2007: Carla A Borgoño; Iacovos Michael; Nahoko Komatsu; Arumugam Jayakumar; Ravi Kapadia; Gary L Clayman; Georgia Sotiropoulou; Eleftherios P Diamandis
A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.
The Journal of biological chemistry 2007;282(6):3640-52.
2007: Julie L V Shaw; Linda Grass; Georgia Sotiropoulou; Eleftherios P Diamandis
Development of an immunofluorometric assay for human kallikrein 15 (KLK15) and identification of KLK15 in tissues and biological fluids.
Clinical biochemistry 2007;40(1-2):104-10.
2006: Georgios Pampalakis; Eleftherios P Diamandis; Georgia Sotiropoulou
The epigenetic basis for the aberrant expression of kallikreins in human cancers.
Biological chemistry 2006;387(6):795-9.
2006: Georgios Pampalakis; Georgia Sotiropoulou
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.
Biological chemistry 2006;387(6):773-82.
2006: Iacovos Michael; Georgios Pampalakis; Stephen D Mikolajczyk; Johan Malm; Georgia Sotiropoulou; Eleftherios P Diamandis
Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression.
The Journal of biological chemistry 2006;281(18):12743-50.
2005: Michael Sidiropoulos; Georgios Pampalakis; Georgia Sotiropoulou; Dionyssios Katsaros; Eleftherios P Diamandis
Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005;26(6):324-36.
2005: Christina V Obiezu; Shannon J C Shan; Antoninus Soosaipillai; Liu-Ying Luo; Linda Grass; Georgia Sotiropoulou; Constantina D Petraki; Panagiotis A Papanastasiou; Michael A Levesque; Eleftherios P Diamandis
Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids.
Clinical chemistry 2005;51(8):1432-42.
2005: Iacovos Michael; Georgia Sotiropoulou; Georgios Pampalakis; Angeliki Magklara; Manik Ghosh; Gregory A Wasney; Eleftherios P Diamandis
Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression.
The Journal of biological chemistry 2005;280(15):14628-35.
2004: Georgios Pampalakis; Lisa Kurlender; Eleftherios P Diamandis; Georgia Sotiropoulou
Cloning and characterization of novel isoforms of the human kallikrein 6 gene.
Biochemical and biophysical research communications 2004;320(1):54-61.
2004: Manik C Ghosh; Linda Grass; Antoninus Soosaipillai; Georgia Sotiropoulou; Eleftherios P Diamandis
Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2004;25(4):193-9.
2004: Alex Bayés; Theodoros Tsetsenis; Salvador Ventura; Josep Vendrell; Francesc Aviles; Georgia Sotiropoulou
Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation.
Biological chemistry 2004;385(6):517-24.
2003: Angeliki Magklara; Ali A Mellati; Gregory A Wasney; Sheila P Little; Georgia Sotiropoulou; Gerald Becker; Eleftherios P Diamandis
Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.
Biochemical and biophysical research communications 2003;307(4):948-55.
2003: Georgia Sotiropoulou; Vassilios Rogakos; Theodoros Tsetsenis; Georgios Pampalakis; Nikolaos Zafiropoulos; George Simillides; Athanassios Yiotakis; Eleftherios P Diamandis
Emerging interest in the kallikrein gene family for understanding and diagnosing cancer.
Oncology research 2003;13(6-10):381-91.
2003: Carl Kapadia; Albert Chang; Georgia Sotiropoulou; George M Yousef; Linda Grass; Antoninus Soosaipillai; Xuekun Xing; David H C Howarth; Eleftherios P Diamandis
Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay.
Clinical chemistry 2003;49(1):77-86.
2002: F Xavier Gomis-Rüth; Alex Bayés; Georgia Sotiropoulou; Georgios Pampalakis; Theodoros Tsetsenis; Virtudes Villegas; Francesc X Avilés; Miquel Coll
The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
The Journal of biological chemistry 2002;277(30):27273-81.
2002: Georgia Sotiropoulou; Mari Kono; Anthony Anisowicz; Göran Stenman; Shuichi Tsuji; Ruth Sager
Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer.
Molecular medicine (Cambridge, Mass.) 2002;8(1):42-55.
2000: H Dionyssopoulou; Athanasia Mouzaki; Jerry W Slootstra; Wouter C Puijk; Rob H Meloen; Paul Cordopatis; Georgia Sotiropoulou
Synthetic peptides as putative therapeutic agents in transplantation medicine: application of PEPSCAN to the identification of functional sequences in the extracellular domain of the interleukin-2 receptor beta chain (IL-2Rbeta).
Journal of immunological methods 2000;241(1-2):83-95.
2000: Eleftherios P Diamandis; George M Yousef; Antoninus Soosaipillai; Linda Grass; A Porter; S Little; Georgia Sotiropoulou
Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications.
Clinical biochemistry 2000;33(5):369-75.
2000: Christina Aletra; Panagiota Ravazoula; Chrisoula D Scopa; S Kounelis; Georgia Sotiropoulou; George Kourounis; I Ladopoulos; Dionysis S Bonikos
Expression of bcl-2 and bax in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix.
European journal of gynaecological oncology 2000;21(5):494-8.
1999: George M Yousef; Liu-Ying Luo; Stephen W Scherer; Georgia Sotiropoulou; Eleftherios P Diamandis
Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease.
Genomics 1999;62(2):251-9.
1999: Anthony Anisowicz; Georgia Sotiropoulou; Ruth Sager
Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.
Molecular medicine (Cambridge, Mass.) 1999;5(8):526-41.
1997: Georgia Sotiropoulou; Anthony Anisowicz; Ruth Sager
Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer.
The Journal of biological chemistry 1997;272(2):903-10.
1997: Göran Stenman; AK Aström; Eva Röijer; Georgia Sotiropoulou; M Zhang; Ruth Sager
Assignment of a novel cysteine proteinase inhibitor (CST6) to 11q13 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1997;76(1-2):45-6.
1996: Anthony Anisowicz; Georgia Sotiropoulou; Göran Stenman; S C Mok; Ruth Sager
A novel protease homolog differentially expressed in breast and ovarian cancer.
Molecular medicine (Cambridge, Mass.) 1996;2(5):624-36.
1994: Ruth Sager; Shijie Sheng; Anthony Anisowicz; Georgia Sotiropoulou; Z Zou; Göran Stenman; K Swisshelm; Z Chen; Mary J C Hendrix; P Pemberton
RNA genetics of breast cancer: maspin as paradigm.
Cold Spring Harbor symposia on quantitative biology 1994;59():537-46.
1993: Ruth Sager; Anthony Anisowicz; M Neveu; P Liang; Georgia Sotiropoulou
Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(10):964-70.