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Karel Soucek

Research Profile

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

myb Genes

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Publications

TOP 3
Petr Benes; Lucia Knopfova; Filip Trcka; Alice Nemajerova; Diana Pinheiro; Karel Soucek; Miroslav Fojta; Jan Smarda
Inhibition of topoisomerase IIα: novel function of wedelolactone.
Olga Vondálová Blanárová; Iva Jelínková; Arpád Szöor; Belma Skender; Karel Soucek; Viktor Horváth; Alena Vaculová; Ladislav Andera; Petr Sova; János Szöllosi; Jirina Hofmanová; György Vereb; Alois Kozubík
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Karel Soucek; Eva Slabáková; Petra Ovesná; Alice Malenovská; Alois Kozubík; Ales Hampl
Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma.

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All Publications

2011: Petr Benes; Lucia Knopfova; Filip Trcka; Alice Nemajerova; Diana Pinheiro; Karel Soucek; Miroslav Fojta; Jan Smarda
Inhibition of topoisomerase IIα: novel function of wedelolactone.
Cancer letters 2011;303(1):29-38.
2011: Olga Vondálová Blanárová; Iva Jelínková; Arpád Szöor; Belma Skender; Karel Soucek; Viktor Horváth; Alena Vaculová; Ladislav Andera; Petr Sova; János Szöllosi; Jirina Hofmanová; György Vereb; Alois Kozubík
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Carcinogenesis 2011;32(1):42-51.
2010: Karel Soucek; Eva Slabáková; Petra Ovesná; Alice Malenovská; Alois Kozubík; Ales Hampl
Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma.
Human reproduction (Oxford, England) 2010;25(12):2962-71.
2010: Andrea Starsíchová; Eva Lincová; Zuzana Pernicová; Alois Kozubík; Karel Soucek
TGF-beta1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells.
Cellular signalling 2010;22(11):1734-44.
2010: Lenka Švihálková-Šindlerová; Vendula Foltinová; Alena Vaculová; Viktor Horváth; Karel Soucek; Petr Sova; Jirina Hofmanová; Alois Kozubík
LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds.
Anticancer research 2010;30(4):1183-8.
2010: Karel Soucek; Pavla Gajdusková; Marie Brázdová; Martina Hýzd'alová; Lenka Kocí; David Vydra; Radek Trojanec; Zuzana Pernicová; Lenka Lentvorská; Marián Hajdúch; Jirina Hofmanová; Alois Kozubík
Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation.
Cancer genetics and cytogenetics 2010;197(2):107-16.
2009: Rastislav Jendzelovský; Jaromir Mikes; Ján Koval'; Karel Soucek; Jirina Procházková; Martin Kello; Veronika Sacková; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2009;8(12):1716-23.
2009: Petr Vanhara; Eva Lincová; Alois Kozubík; Pierre Jurdic; Karel Soucek; Jan Smarda
Growth/differentiation factor-15 inhibits differentiation into osteoclasts--a novel factor involved in control of osteoclast differentiation.
Differentiation; research in biological diversity 2009;78(4):213-22.
2009: Lenka Stixová; Jirina Procházková; Karel Soucek; Jirina Hofmanová; Alois Kozubík
5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway.
Molecular and cellular biochemistry 2009;330(1-2):229-38.
2009: Eva Lincová; Ales Hampl; Zuzana Pernicová; Andrea Starsíchová; Pavel Krcmár; Miroslav Machala; Alois Kozubík; Karel Soucek
Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs.
Biochemical pharmacology 2009;78(6):561-72.
2009: Jirina Procházková; Lenka Stixová; Karel Soucek; Jirina Hofmanová; Alois Kozubík
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery.
European journal of haematology 2009;83(1):35-47.
2009: Emanuela Maioli; Lucedio Greci; Karel Soucek; Martina Hyzdalova; Alessandra Pecorelli; Vittoria Fortino; Giuseppe Valacchi
Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells.
Journal of biomedicine & biotechnology 2009;2009():742936.
2008: V Bryja; Jirí Pacherník; Jan Vondrácek; Karel Soucek; L Cajánek; V Horvath; Z Holubcová; P Dvorák; A Hampl
Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin.
Cell proliferation 2008;41(6):875-93.
2008: Eva Ondrousková; Karel Soucek; Viktor Horváth; Jan Smarda
Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis.
Leukemia research 2008;32(4):599-609.
2008: Claudia Torricelli; Vittoria Fortino; Elisa Capurro; Giuseppe Valacchi; Adriana Pacini; Michela Muscettola; Karel Soucek; Emanuela Maioli
Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells.
Life sciences 2008;82(11-12):638-43.
2008: Alois Kozubík; Alena Vaculová; Karel Soucek; Jan Vondrácek; Jaroslav Turánek; Jirina Hofmanová
Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism.
Metal-based drugs 2008;2008():417897.
2007: Viktor Horváth; Karel Soucek; Lenka Švihálková-Šindlerová; Jan Vondrácek; Olga Blanárová; Jirina Hofmanová; Petr Sova; Alois Kozubík
Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin.
Investigational new drugs 2007;25(5):435-43.
2006: Alena Vaculová; Jirina Hofmanová; Karel Soucek; Alois Kozubík
Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
FEBS letters 2006;580(28-29):6565-9.
2006: Anh Phung; Karel Soucek; Lukas Kubala; Richart W Harper; J Chloë Bulinski; Jason P Eiserich
Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells.
European journal of cell biology 2006;85(12):1241-52.
2006: Viktor Horváth; Olga Blanárová; Lenka Švihálková-Šindlerová; Karel Soucek; Jirina Hofmanová; Petr Sova; Ales Kroutil; Peter Fedorocko; Alois Kozubík
Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells.
Gynecologic oncology 2006;102(1):32-40.
2006: Karel Soucek; Andrés Kamaid; Anh Phung; Lukas Kubala; J Chloë Bulinski; Richart W Harper; Jason P Eiserich
Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications.
The Prostate 2006;66(9):954-65.
2006: Paul Davis; John A Polagruto; Giuseppe Valacchi; Anh Phung; Karel Soucek; Carl L Keen; M Eric Gershwin
Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells.
Experimental biology and medicine (Maywood, N.J.) 2006;231(5):594-8.
2006: Karel Soucek; Jirí Pacherník; Lukas Kubala; Jan Vondrácek; Jirina Hofmanová; Alois Kozubík
Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis.
Leukemia research 2006;30(5):607-23.
2006: Jan Vondrácek; Karel Soucek; Michael A Sheard; Katerina Chramostová; Zdenek Andrysík; Jirina Hofmanová; Alois Kozubík
Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization.
Leukemia research 2006;30(1):81-9.
2005: Richart W Harper; Changhong Xu; Karel Soucek; Henny Setiadi; Jason P Eiserich
A reappraisal of the genomic organization of human Nox1 and its splice variants.
Archives of biochemistry and biophysics 2005;435(2):323-30.
2005: Alois Kozubík; Viktor Horváth; Lenka Švihálková-Šindlerová; Karel Soucek; Jirina Hofmanová; Petr Sova; Ales Kroutil; Frantisek Zák; Adolf Mistr; Jaroslav Turánek
High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro.
Biochemical pharmacology 2005;69(3):373-83.
2004: Alena Vaculová; Jirina Hofmanová; Karel Soucek; Ladislav Andera; Alois Kozubík
Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis.
FEBS letters 2004;577(1-2):309-13.
2004: Vítezslav Bryja; Jirí Pacherník; Karel Soucek; V Horvath; Petr Dvorák; Ales Hampl
Increased apoptosis in differentiating p27-deficient mouse embryonic stem cells.
Cellular and molecular life sciences : CMLS 2004;61(11):1384-400.
2004: Martina Kovaríková; Jirina Hofmanová; Karel Soucek; Alois Kozubík
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.
Differentiation; research in biological diversity 2004;72(1):23-31.
2004: Zuzana Hoferová; Karel Soucek; Jirina Hofmanová; Michal Hofer; Katerina Chramostová; Peter Fedorocko; Alois Kozubik
In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase.
Cancer investigation 2004;22(2):234-47.
2003: Eva Zahradnícková; Karel Soucek; Sabina Sevcíková; Jana Smardová; Jan Smarda
c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts.
Cellular and molecular life sciences : CMLS 2003;60(12):2736-48.
2003: Vítezslav Bryja; Jirí Sedlácek; Eva Zahradnícková; Sabina Sevcíková; Jirí Pacherník; Karel Soucek; Jirina Hofmanová; Alois Kozubík; Jan Smarda
Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.
Prostaglandins & other lipid mediators 2003;72(3-4):131-45.
2003: Eva Bártová; Pavla Jirsová; Miloslava Fojtová; Karel Soucek; Stanislav Kozubek
Chromosomal territory segmentation in apoptotic cells.
Cellular and molecular life sciences : CMLS 2003;60(5):979-90.
2003: Alice Nemajerová; Jan Smarda; Pierre Jurdic; Lukas Kubala; Karel Soucek; Jana Smardová
Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells.
Journal of hematotherapy & stem cell research 2003;12(2):225-35.
2003: Zuzana Hoferová; Antonín Vacek; Michal Hofer; Nadezda O Macková; Karel Soucek; Alena Egyed; Peter Fedorocko
Tumor-host interactions accompanying the growth of the G:5:113 fibrosarcoma in the mouse: possibilities for a new therapeutic approach?
Cancer investigation 2003;21(2):227-36.
2002: Sabina Sevcíková; Karel Soucek; Lukas Kubala; Vítezslav Bryja; Jan Smarda
Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts.
Cellular and molecular life sciences : CMLS 2002;59(10):1690-705.
2002: Alena Vaculová; Jirina Hofmanova; Karel Soucek; Martina Kovariková; Alois Kozubík
Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells.
Anticancer research 2002;22(3):1635-9.
2002: Jirí Pacherník; Ales Hampl; Karel Soucek; Martina Kovaríková; Zdenek Andrysík; Jirina Hofmanová; Alois Kozubík
Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.
Archives of dermatological research 2002;293(12):626-33.
2002: Jirina Hofmanová; Karel Soucek; Jirí Pacherník; Martina Kovaríková; Zuzana Hoferová; Katerina Minksová; J Netíková; Alois Kozubík
Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.
Neoplasma 2002;49(6):362-7.
2002: Zuzana Hoferová; Peter Fedorocko; Jirina Hofmanová; Michal Hofer; Vladimír Znojil; Katerina Minksová; Karel Soucek; Alena Egyed; Alois Kozubík
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
Cancer investigation 2002;20(4):490-8.
2001: Jan Vondrácek; J Stika; Karel Soucek; Katerina Minksová; Ludek Bláha; Jirina Hofmanová; Alois Kozubík
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
European journal of pharmacology 2001;424(1):1-11.
2001: Jirí Pacherník; Karel Soucek; Ales Hampl; Jirina Hofmanová; Alois Kozubík
Transforming growth factor-beta1 induces junB mRNA accumulation, G1-phase arrest, and pRb dephosphorylation in human leukemia HL-60 cells.
Folia biologica 2001;47(1):32-5.
2000: Petr Vodicka; Sabina Sevcíková; Jana Smardová; Karel Soucek; Jan Smarda
The effects of RARalpha and RXRalpha proteins on growth, viability, and differentiation of v-myb-transformed monoblasts.
Blood cells, molecules & diseases 2000;26(4):395-406.
2000: Jirina Hofmanová; Karel Soucek; L Dusek; J Netíková; Alois Kozubík
Inhibition of the cytochrome P-450 modulates all-trans-retinoic acid-induced differentiation and apoptosis of HL-60 cells.
Cancer detection and prevention 2000;24(4):325-42.