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Frederick Southwick

Research Profile

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TOP 3
Ellen A Bishai; Aparna B Bohil; Richard E Cheney; Jess Dhillon; John H Hartwig; Wei Li; Gurjit S Sidhu; Frederick S Southwick
Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
J Glenn Morris; Frederick S Southwick
Brucella, voles, and emerging pathogens.
Sarah E Szarowicz; Russell L During; Wei Li; Conrad P Quinn; Wei-Jen Tang; Frederick S Southwick
Bacillus anthracis edema toxin impairs neutrophil actin-based motility.

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All Publications

2013: Ellen A Bishai; Aparna B Bohil; Richard E Cheney; Jess Dhillon; John H Hartwig; Wei Li; Gurjit S Sidhu; Frederick S Southwick
Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
Cellular microbiology 2013;15(3):353-67.
2010: J Glenn Morris; Frederick S Southwick
Brucella, voles, and emerging pathogens.
The Journal of infectious diseases 2010;202(1):1-2.
2009: Sarah E Szarowicz; Russell L During; Wei Li; Conrad P Quinn; Wei-Jen Tang; Frederick S Southwick
Bacillus anthracis edema toxin impairs neutrophil actin-based motility.
Infection and immunity 2009;77(6):2455-64.
2007: Russell L During; bruce gibson; Wei Li; Ellen A Bishai; Gurjit S Sidhu; Jacques Landry; Frederick S Southwick
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.
The EMBO journal 2007;26(9):2240-50.
2007: Frederick S Southwick
Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook.
Transactions of the American Clinical and Climatological Association 2007;118():115-22.
2006: Y Zhang; Sergey M Vorobiev; bruce gibson; Binghua Hao; Gurjit S Sidhu; Vishnu S Mishra; Elena G Yarmola; michael bubb; Steven C Almo; Frederick S Southwick
A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
The EMBO journal 2006;25(19):4458-67.
2005: Russell L During; Wei Li; Binghua Hao; Joyce M Koenig; David S Stephens; Conrad P Quinn; Frederick S Southwick
Anthrax lethal toxin paralyzes neutrophil actin-based motility.
The Journal of infectious diseases 2005;192(5):837-45.
2005: Gurjit S Sidhu; Wei Li; Nicholas Laryngakis; Ellen Bishai; Tamas Balla; Frederick S Southwick
Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation.
The Journal of biological chemistry 2005;280(12):11379-86.
2005: Laura Larson; Serge Arnaudeau; Bruce Gibson; Wei Li; Ryoko Krause; Binghua Hao; James R Bamburg; Daniel Lew; Nicolas Demaurex; Frederick S Southwick
Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1921-6.
2003: Shefal S Parikh; Sally A Litherland; Michael J Clare-Salzler; Wei Li; Paul A Gulig; Frederick S Southwick
CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity 2003;71(11):6582-90.
2003: michael bubb; Elena G Yarmola; bruce gibson; Frederick S Southwick
Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
The Journal of biological chemistry 2003;278(27):24629-35.
2003: Frederick S Southwick; Wei Li; Fangliang Zhang; William L Zeile; Daniel L Purich
Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
Cell motility and the cytoskeleton 2003;54(1):41-55.
2002: Richard B Dickinson; Frederick S Southwick; Daniel L Purich
A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
Archives of biochemistry and biophysics 2002;406(2):296-301.
2002: Fangliang Zhang; Frederick S Southwick; Daniel L Purich
Actin-based phagosome motility.
Cell motility and the cytoskeleton 2002;53(2):81-8.
2002: Velizar T Tchernev; Traci A Mansfield; Loic Giot; A Madan Kumar; Krishnan Nandabalan; Ying Li; Vishnu S Mishra; John C Detter; Jonathan M Rothberg; Margaret R Wallace; Frederick S Southwick; Stephen Kingsmore
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Molecular medicine (Cambridge, Mass.) 2002;8(1):56-64.
2001: Frederick S Southwick
Who was caring for Mary? 1993.
Obstetrics and gynecology 2001;98(6):1140-2.
2000: Frederick S Southwick
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):6936-8.
2000: Frederick S Southwick; E D Adamson; Daniel L Purich
Shigella actin-based motility in the presence of truncated vinculin.
Cell motility and the cytoskeleton 2000;45(4):272-8.
1999: F Kang; Daniel L Purich; Frederick S Southwick
Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
The Journal of biological chemistry 1999;274(52):36963-72.
1999: Daniel L Purich; Frederick S Southwick
Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular cell biology research communications : MCBRC 1999;1(3):176-81.
1999: Daniel L Purich; Frederick S Southwick
Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
Methods in enzymology 1999;308():93-111.
1998: William L Zeile; Richard C Condit; JI Lewis; Daniel L Purich; Frederick S Southwick
Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13917-22.
1998: Roney O Laine; K L Phaneuf; C C Cunningham; D Kwiatkowski; T Azuma; Frederick S Southwick
Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells.
Infection and immunity 1998;66(8):3775-82.
1998: Frederick S Southwick; Daniel L Purich
Listeria and Shigella actin-based motility in host cells.
Transactions of the American Clinical and Climatological Association 1998;109():160-72; discussion 172-3.
1997: Roney O Laine; William L Zeile; F Kang; Daniel L Purich; Frederick S Southwick
Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.
The Journal of cell biology 1997;138(6):1255-64.
1997: F Kang; Roney O Laine; michael bubb; Frederick S Southwick; Daniel L Purich
Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility.
Biochemistry 1997;36(27):8384-92.
1997: Daniel L Purich; Frederick S Southwick
ABM-1 and ABM-2 homology sequences: consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP.
Biochemical and biophysical research communications 1997;231(3):686-91.
1996: W L Zeile; Daniel L Purich; Frederick S Southwick
Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.
The Journal of cell biology 1996;133(1):49-59.
1996: Frederick S Southwick; Daniel L Purich
Intracellular pathogenesis of listeriosis.
The New England journal of medicine 1996;334(12):770-6.
1996: N A Maun; D W Speicher; M J DiNubile; Frederick S Southwick
Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.
Biochemistry 1996;35(11):3518-24.
1995: Frederick S Southwick
Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
The Journal of biological chemistry 1995;270(1):45-8.
1995: Frederick S Southwick; Daniel L Purich
Inhibition of Listeria locomotion by mosquito oostatic factor, a natural oligoproline peptide uncoupler of profilin action.
Infection and immunity 1995;63(1):182-90.
1995: Jean M Sanger; BALRAJ MITTAL; Frederick S Southwick; Joseph W Sanger
Listeria monocytogenes intracellular migration: inhibition by profilin, vitamin D-binding protein and DNase I.
Cell motility and the cytoskeleton 1995;30(1):38-49.
1994: Frederick S Southwick; Daniel L Purich
Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5168-72.
1994: C L Young; A Feierstein; Frederick S Southwick
Calcium regulation of actin filament capping and monomer binding by macrophage capping protein.
The Journal of biological chemistry 1994;269(19):13997-4002.
1992: Jean M Sanger; Joseph W Sanger; Frederick S Southwick
Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
Infection and immunity 1992;60(9):3609-19.
1992: Guissou A Dabiri; C L Young; Joel Rosenbloom; Frederick S Southwick
Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
The Journal of biological chemistry 1992;267(23):16545-52.
1991: P J Brennan; Sally H Zigmond; Alan D Schreiber; E R Smith; Frederick S Southwick
Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4282-8.
1990: Guissou A Dabiri; Jean M Sanger; Daniel A Portnoy; Frederick S Southwick
Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6068-72.
1990: Frederick S Southwick; C L Young
The actin released from profilin--actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.
The Journal of cell biology 1990;110(6):1965-73.
1990: C L Young; Frederick S Southwick; A Weber
Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period.
Biochemistry 1990;29(9):2232-40.
1989: Frederick S Southwick; Guissou A Dabiri; M Paschetto; Sally H Zigmond
Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
The Journal of cell biology 1989;109(4 Pt 1):1561-9.
1989: Frederick S Southwick; T H Howard; T Holbrook; D C Anderson; Thomas P Stossel; M A Arnaout
The relationship between CR3 deficiency and neutrophil actin assembly.
Blood 1989;73(7):1973-9.
1988: Frederick S Southwick; Guissou A Dabiri; Thomas P Stossel
Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members.
The Journal of clinical investigation 1988;82(5):1525-31.
1988: M J DiNubile; Frederick S Southwick
Contractile proteins in leukocytes.
Methods in enzymology 1988;162():246-71.
1987: M Shalit; Guissou A Dabiri; Frederick S Southwick
Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly.
Blood 1987;70(6):1921-7.
1986: Frederick S Southwick; M J DiNubile
Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the "barbed" ends of actin filaments but does not sever them.
The Journal of biological chemistry 1986;261(30):14191-5.
1985: M J DiNubile; Frederick S Southwick
Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin.
The Journal of biological chemistry 1985;260(12):7402-9.