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Matthew Bogyo

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Aurélien Godinat; Douglas Hanahan; Stephen C Miller; Gennady F Nikitin; Hyo Min Park; Laura E Sanman; Andreas Stahl; Allen Yu; Matthew Bogyo; Ke Cheng; Elena A Dubikovskaya
A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.
Haibin Lu; Julian Oeljeklaus; Mohammed Shabab; Matthew Bogyo; Markus Kaiser; Farnusch Kaschani; Steven H L Verhelst; Zheming Wang; Renier A L Van der Hoorn
A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB.
Matthew Bogyo; Pauline M Rudd
New technologies and their impact on 'omics' research.

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2013: Aurélien Godinat; Douglas Hanahan; Stephen C Miller; Gennady F Nikitin; Hyo Min Park; Laura E Sanman; Andreas Stahl; Allen Yu; Matthew Bogyo; Ke Cheng; Elena A Dubikovskaya
A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.
ACS chemical biology 2013;8(5):987-99.
2013: Haibin Lu; Julian Oeljeklaus; Mohammed Shabab; Matthew Bogyo; Markus Kaiser; Farnusch Kaschani; Steven H L Verhelst; Zheming Wang; Renier A L Van der Hoorn
A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB.
Chemistry & biology 2013;20(2):168-76.
2013: Matthew Bogyo; Pauline M Rudd
New technologies and their impact on 'omics' research.
Current opinion in chemical biology 2013;17(1):1-3.
2013: Jiyoun Lee; Matthew Bogyo
Target deconvolution techniques in modern phenotypic profiling.
Current opinion in chemical biology 2013;17(1):118-26.
2013: Johana C Misas-Villamil; Amir M Sadaghiani; Gerrit Toenges; Matthew Bogyo; Thomas Colby; Farnusch Kaschani; Izabella Kolodziejek; Renier A L Van der Hoorn
Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection.
The Plant journal : for cell and molecular biology 2013;73(4):689-700.
2013: Laura E Edgington; Jiyoun Lee; Alberto Ortega; Salahuddin Syed; Martijn Verdoes; Nimali P Withana; Michael H Bachmann; Galia Blum; Matthew Bogyo
Functional imaging of legumain in cancer using a new quenched activity-based probe.
Journal of the American Chemical Society 2013;135(1):174-82.
2012: Sara Christina Stolze; Renier A L Van der Hoorn; Matthew Bogyo; Tom Colby; Edgar Deu; Bogdan I Florea; Farnusch Kaschani; Nan Li; Hermen S Overkleeft; Kerstin H Richau; Markus Kaiser
The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.
Chemistry & biology 2012;19(12):1546-55.
2012: Hao Li; Elizabeth L Ponder; Martijn Verdoes; Kim C Williamson; Susan D Demo; Edgar Deu; Laura E Edgington; Christopher J Kirk; Jeong Tae Lee; Kristijana H Asbjornsdottir; Matthew Bogyo
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity.
Chemistry & biology 2012;19(12):1535-45.
2012: Stefanie R Mullins; Mansoureh Sameni; Bonnie F Sloane; Galia Blum; Matthew Bogyo; Kamiar Moin
Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.
Biological chemistry 2012;393(12):1405-16.
2012: Dennis J Goussetis; Jessica K Altman; Matthew Bogyo; Elias Gounaris; Bhumika Sharma; Eliza Vakana; Edward J Wu; Leonidas C Platanias
Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide.
Blood 2012;120(17):3555-62.
2012: Victoria Lyo; James Ostroff; Margot Paulick; Austin W Walker; Matthew Bogyo; Nigel W Bunnett; James Buxbaum; fiore cattaruzza; Jordan Cloyd; Daniel Cox; Eileen F Grady; Tyson N Kim; Kimberly S Kirkwood
Active cathepsins B, L, and S in murine and human pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(8):G894-903.
2012: Maryta Sztukowska; Ida B Thogersen; Florian Veillard; Matthew Bogyo; Jan J Enghild; Ky-Anh Nguyen; Barbara Potempa; Jan Potempa
Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.
Biological chemistry 2012;393(9):971-7.
2012: Guy S Salvesen; Matthew Bogyo
Highlight: the universe of proteolytic networks and mechanisms.
Biological chemistry 2012;393(9):841.
2012: Aaron W Puri; Aimee Shen; Petr Broz; Denise M Monack; Matthew Bogyo
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.
Nature chemical biology 2012;8(9):745-7.
2012: Martijn Verdoes; Kipp Weiskopf; Michael H Bachmann; Galia Blum; Laura E Edgington; Jonathan A Ellman; Melissa Leyva; Ferenc A Scheeren; Matthew Bogyo
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.
Chemistry & biology 2012;19(5):619-28.
2012: Karine Sá Ferreira; Angelika Haber; Clemens Kreutz; Sabine Macnelly; Karin Neubert; Jens Timmer; Matthew Bogyo; Christoph Borner
Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes.
Apoptosis : an international journal on programmed cell death 2012;17(5):503-15.
2012: Kerstin H Richau; Kurt Stüber; Martijn Verdoes; Matthew Bogyo; Tom Colby; Farnusch Kaschani; Sherry Niessen; Herman S Overkleeft; Twinkal C Pansuriya; Renier A L Van der Hoorn
Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.
Plant physiology 2012;158(4):1583-99.
2012: Jun Li; Qi Wu; Pingar Yang; Matthew Bogyo; Laura E Edgington; Hui-Chen Hsu; Robert P Kimberly; Hao Li; John D Mountz
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.
Arthritis and rheumatism 2012;64(4):1098-109.
2012: Laura E Edgington; Guy S Salvesen; Bram J van Raam; Martijn Verdoes; Christoph Wierschem; Matthew Bogyo
An optimized activity-based probe for the study of caspase-6 activation.
Chemistry & biology 2012;19(3):340-52.
2012: Jiyoun Lee; Matthew Bogyo
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Bioorganic & medicinal chemistry letters 2012;22(3):1340-3.
2012: Magdalena Kalińska; Tomasz Kantyka; Katrine S Larsen; Adam Lesner; Jan Potempa; Krzysztof Rolka; Norbert Schaschke; Henning Stennicke; Benedykt Władyka; Magdalena Wysocka; Matthew Bogyo; Patrick S Daugherty; Adam Dubin; Doron C Greenbaum; Abeer Jabaiah; Marcelina Jaros; Grzegorz Dubin
Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.
Biochimie 2012;94(2):318-27.
2012: Jennifer L Cutter; Ashok Panneerselvam; Mark Schluchter; Andrew E Sloan; Jing Wang; Galia Blum; Matthew Bogyo; Alan R Cohen; Nathan T Cohen; James P Basilion
Topical application of activity-based probes for visualization of brain tumor tissue.
PloS one 2012;7(3):e33060.
2012: Heather M Fritz; Matthew Bogyo; Paul W Bowyer; Patricia A Conrad; John C Boothroyd
Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance.
PloS one 2012;7(1):e29955.
2012: Hao Li; Matthew A Child; Matthew Bogyo
Proteases as regulators of pathogenesis: examples from the Apicomplexa.
Biochimica et biophysica acta 2012;1824(1):177-85.
2011: fiore cattaruzza; James Hawkins; Charles Ibeakanma; Ella Jones; Kimberley Kirkwood; Victoria Lyo; David Pham; Eduardo Valdez-Morales; Stephen Vanner; Matthew Bogyo; Nigel W Bunnett
Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice.
Gastroenterology 2011;141(5):1864-74.e1-3.
2011: Georgy Mikhaylov; Evgeniy P Naiden; Christoph Peters; Ivan Psakhye; Sergey G Psakhye; Thomas Reinheckel; Boris Turk; Vito Turk; Liane Babes; Matthew Bogyo; Volya I Itin; Anna A Magaeva; Ursa Mikac; Robert Zeiser; Olga Vasiljeva
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment.
Nature nanotechnology 2011;6(9):594-602.
2011: Carolyn I Hall; Jeralyn D Haraldsen; MacDonald R Phillips; Michael L Reese; Edgar Deu Sandoval; Gary E Ward; Eranthie Weerapana; John C Boothroyd; Paul W Bowyer; Matthew A Child; Benjamin F Cravatt; Victoria E Albrow; Matthew Bogyo
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10568-73.
2011: Victoria E Albrow; Miklós Békés; Edgar Deu; Domenico Fasci; Elizabeth L Ponder; Guy S Salvesen; Matthew Bogyo
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
Chemistry & biology 2011;18(6):722-32.
2011: Elizabeth L Ponder; James C Powers; Guy S Salvesen; Aimee Shen; Junpeng Xiao; Amy J Campbell; Edgar Deu; Marcin Drag; Urša Pečar Fonović; Brittany A Leader; Jowita Mikolajczyk; Victoria E Albrow; Miklós Békés; Matthew Bogyo
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
Chemistry & biology 2011;18(6):711-21.
2011: Margot G Paulick; Matthew Bogyo
Development of activity-based probes for cathepsin X.
ACS chemical biology 2011;6(6):563-72.
2011: Paul W Bowyer; Gabriel M Simon; Benjamin F Cravatt; Matthew Bogyo
Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte.
Molecular & cellular proteomics : MCP 2011;10(5):M110.001636.
2011: Sarah E Ewald; Alex Engel; Jiyoun Lee; Miqi Wang; Matthew Bogyo; Gregory M Barton
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.
The Journal of experimental medicine 2011;208(4):643-51.
2011: Sumit S Mahajan; Edgar Deu; Erica M W Lauterwasser; Melissa J Leyva; Jonathan A Ellman; Matthew Bogyo; Adam R Renslo
A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite.
ChemMedChem 2011;6(3):415-9.
2011: Aimee Shen; Patrick J Lupardus; Malte M Gersch; Aaron W Puri; Victoria E Albrow; K Christopher Garcia; Matthew Bogyo
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
Nature structural & molecular biology 2011;18(3):364-71.
2011: Gang Ren; Salahuddin Syed; Martijn Verdoes; Galia Blum; Matthew Bogyo; Laura E Edgington; Sanjiv Sam Gambhir; Olivier Gheysens; Han Jiang; Hongguang Liu; Zheng Miao; Zhen Cheng
Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.
PloS one 2011;6(11):e28029.
2011: Sofia Tedelind; Galia Blum; Matthew Bogyo; Dagmar Führer; Silvia Jordans; Henrike Resemann; Klaudia Brix
Cathepsin B trafficking in thyroid carcinoma cells.
Thyroid research 2011;4 Suppl 1():S2.
2011: Flora Wang; Priscilla Krai; Edgar Deu; Brittney Bibb; Conni Lauritzen; John Pedersen; Matthew Bogyo; Michael Klemba
Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1.
Molecular and biochemical parasitology 2011;175(1):10-20.
2010: Aaron W Puri; Patrick J Lupardus; Edgar Deu; Victoria E Albrow; K Christopher Garcia; Matthew Bogyo; Aimee Shen
Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.
Chemistry & biology 2010;17(11):1201-11.
2010: Nicole D Staudt; Wilhelm K Aicher; Hubert Kalbacher; Stefan Stevanovic; Adriana K Carmona; Matthew Bogyo; Gerd Klein
Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts.
Haematologica 2010;95(9):1452-60.
2010: Edgar Deu; Melissa J Leyva; Victoria E Albrow; Mark J Rice; Jonathan A Ellman; Matthew Bogyo
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.
Chemistry & biology 2010;17(8):808-19.
2010: Sofia Tedelind; Kseniia Poliakova; Amanda Valeta; Ruth Hunegnaw; Eyoel Lemma Yemanaberhan; Nils-Erik Heldin; Junichi Kurebayashi; Ekkehard Weber; Natasa Kopitar-Jerala; Boris Turk; Matthew Bogyo; Klaudia Brix
Nuclear cysteine cathepsin variants in thyroid carcinoma cells.
Biological chemistry 2010;391(8):923-35.
2010: Spela Konjar; Fangfang Yin; Matthew Bogyo; Boris Turk; Natasa Kopitar-Jerala
Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.
FEBS letters 2010;584(11):2201-6.
2010: Jiyoun Lee; Matthew Bogyo
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
ACS chemical biology 2010;5(2):233-43.
2010: Matthew Bogyo
Finding enzymes that are actively involved in cancer.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2379-80.
2010: Marcin Drag; Matthew Bogyo; Jonathan A Ellman; Guy S Salvesen
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
The Journal of biological chemistry 2010;285(5):3310-8.
2010: Edgar Deu; Zhimou Yang; Flora Wang; Michael Klemba; Matthew Bogyo
Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.
PloS one 2010;5(8):e11985.
2009: Martin Horn; Martina Nussbaumerová; Miloslav Sanda; Zuzana Kovárová; Jindrich Srba; Zdenek Franta; Daniel Sojka; Matthew Bogyo; Conor R Caffrey; Petr Kopácek; Michael Mares
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics.
Chemistry & biology 2009;16(10):1053-63.
2009: Eric T Larson; Fabiola Parussini; My-Hang Huynh; Jonathan D Giebel; Angela M Kelley; Li Zhang; Matthew Bogyo; Ethan A Merritt; Vernon Bruce Carruthers
Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
The Journal of biological chemistry 2009;284(39):26839-50.
2009: Jun Zhang; Marko Fonovic; Kaye Suyama; Matthew Bogyo; Matthew P Scott
Rab35 controls actin bundling by recruiting fascin as an effector protein.
Science (New York, N.Y.) 2009;325(5945):1250-4.
2009: Jeong Tae Lee; David Y Chen; Zhimou Yang; Alexander D Ramos; James Hsieh; Matthew Bogyo
Design, syntheses, and evaluation of Taspase1 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(17):5086-90.
2009: Aaron W Puri; Matthew Bogyo
Using small molecules to dissect mechanisms of microbial pathogenesis.
ACS chemical biology 2009;4(8):603-16.
2009: Laura E Edgington; Alicia B Berger; Galia Blum; Victoria E Albrow; Margot G Paulick; Neil Lineberry; Matthew Bogyo
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes.
Nature medicine 2009;15(8):967-73.
2009: Aimee Shen; Patrick J Lupardus; Victoria E Albrow; Andrew Guzzetta; James C Powers; K Christopher Garcia; Matthew Bogyo
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nature chemical biology 2009;5(7):469-78.
2009: Simone A Beckham; David Piedrafita; Carolyn I Phillips; Nirma Samarawickrema; Ruby H P Law; Peter M Smooker; Noelene S Quinsey; James Irving; Deanne Greenwood; Steven H L Verhelst; Matthew Bogyo; Boris Turk; Theresa H T Coetzer; Lakshmi C Wijeyewickrema; Terry W Spithill; Robert N Pike
A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites.
The international journal of biochemistry & cell biology 2009;41(7):1601-12.
2009: Sung-Hee Chang; Keizo Kanasaki; Vasilena Gocheva; Galia Blum; Jay Harper; Marsha A Moses; Shou-Ching Shih; Janice A Nagy; Johanna A Joyce; Matthew Bogyo; Raghu Kalluri; Harold F Dvorak
VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.
Cancer research 2009;69(10):4537-44.
2009: Simone Barbero; Ainhoa Mielgo; Vicente Torres; Tal Teitz; David J Shields; David Mikolon; Matthew Bogyo; Daniela Barilà; Jill Lahti; David D Schlaepfer; Stupack Dwayne
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.
Cancer research 2009;69(9):3755-63.
2009: Márcia A Liz; Carolina E Fleming; Ana F Nunes; Maria R Almeida; Fernando M Mar; Youngchool Choe; Charles S Craik; James C Powers; Matthew Bogyo; Mónica Mendes Sousa
Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
The Biochemical journal 2009;419(2):467-74.
2009: Natasa Obermajer; Z Jevnikar; Bojan Doljak; A M Sadaghiani; Matthew Bogyo; Janko Kos
Cathepsin X-mediated beta2 integrin activation results in nanotube outgrowth.
Cellular and molecular life sciences : CMLS 2009;66(6):1126-34.
2009: Joze Pungercar; Dejan Caglic; Mohammed Sajid; Marko Dolinar; Olga Vasiljeva; Urska Pozgan; Dusan Turk; Matthew Bogyo; Vito Turk; Boris Turk
Autocatalytic processing of procathepsin B is triggered by proenzyme activity.
The FEBS journal 2009;276(3):660-8.
2009: Zhimou Yang; Marko Fonović; Steven H L Verhelst; Galia Blum; Matthew Bogyo
Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases.
Bioorganic & medicinal chemistry 2009;17(3):1071-8.
2009: Sandeep Ravindran; Melissa B Lodoen; Steven H L Verhelst; Matthew Bogyo; John C Boothroyd
4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion.
PloS one 2009;4(12):e8143.
2009: Aimee Shen; Patrick J Lupardus; Montse Morell; Elizabeth L Ponder; A Masoud Sadaghiani; K Christopher Garcia; Matthew Bogyo
Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag.
PloS one 2009;4(12):e8119.
2009: Galia Blum; Robby M Weimer; Laura E Edgington; Walter Adams; Matthew Bogyo
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity.
PloS one 2009;4(7):e6374.
2009: Farnusch Kaschani; Steven H L Verhelst; Paul F van Swieten; Martijn Verdoes; Chung-Sing Wong; Zheming Wang; Markus Kaiser; Herman S Overkleeft; Matthew Bogyo; Renier A L Van der Hoorn
Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.
The Plant journal : for cell and molecular biology 2009;57(2):373-85.
2008: Natasa Obermajer; Urban Svajger; Matthew Bogyo; Matjaz Jeras; Janko Kos
Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X.
Journal of leukocyte biology 2008;84(5):1306-15.
2008: Patrick J Lupardus; Aimee Shen; Matthew Bogyo; K Christopher Garcia
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.
Science (New York, N.Y.) 2008;322(5899):265-8.
2008: Marko Fonović; Matthew Bogyo
Activity-based probes as a tool for functional proteomic analysis of proteases.
Expert review of proteomics 2008;5(5):721-30.
2008: Aimee Shen; Matthew Bogyo
Friend or foe? Turning a host defense protein into a pathogen's accomplice.
Chemistry & biology 2008;15(9):879-80.
2008: Zala Jevnikar; Natasa Obermajer; Matthew Bogyo; Janko Kos
The role of cathepsin X in the migration and invasiveness of T lymphocytes.
Journal of cell science 2008;121(Pt 16):2652-61.
2008: Uta Schurigt; Lisa Sevenich; Corinne Vannier; Mieczyslaw Gajda; Anne Schwinde; Fee Werner; Andreas Stahl; Dominik von Elverfeldt; Anne-Katrin Becker; Matthew Bogyo; Christoph Peters; Thomas Reinheckel
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.
Biological chemistry 2008;389(8):1067-74.
2008: Shirin Arastu-Kapur; Elizabeth L Ponder; Ursa Pecar Fonović; Sharon Yeoh; Fang Yuan; Marko Fonović; Munira Grainger; Carolyn I Phillips; James C Powers; Matthew Bogyo
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.
Nature chemical biology 2008;4(3):203-13.
2008: Margot G Paulick; Matthew Bogyo
Application of activity-based probes to the study of enzymes involved in cancer progression.
Current opinion in genetics & development 2008;18(1):97-106.
2007: Elizabeth L Ponder; Matthew Bogyo
Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa.
Eukaryotic cell 2007;6(11):1943-52.
2007: Galia Blum; Georges von Degenfeld; Milton J Merchant; Helen M Blau; Matthew Bogyo
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.
Nature chemical biology 2007;3(10):668-77.
2007: Matthew Bogyo
Finding the needles in the haystack: mapping constitutive proteolytic events in vivo.
The Biochemical journal 2007;407(1):e1-2.
2007: Marko Fonović; Steven H L Verhelst; Mark T Sorum; Matthew Bogyo
Proteomics evaluation of chemically cleavable activity-based probes.
Molecular & cellular proteomics : MCP 2007;6(10):1761-70.
2007: Brigitte Goulet; Laurent Sansregret; Lam Leduy; Matthew Bogyo; Ekkehard Weber; Shyam S Chauhan; Alain Nepveu
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.
Molecular cancer research : MCR 2007;5(9):899-907.
2007: Katherine Marie Bell-McGuinn; Alfred L Garfall; Matthew Bogyo; Douglas Hanahan; Johanna A Joyce
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer.
Cancer research 2007;67(15):7378-85.
2007: Patrick P Rose; Matthew Bogyo; Ashlee V Moses; Klaus J Frueh
Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2007;81(15):8050-62.
2007: Daniel Sojka; Ondrej Hajdusek; Josef Dvorák; Mohammed Sajid; Zdenek Franta; Eric L Schneider; Charles S Craik; Marie Vancová; Veronika Buresová; Matthew Bogyo; Kelly B Sexton; James H McKerrow; Conor R Caffrey; Petr Kopácek
IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
International journal for parasitology 2007;37(7):713-24.
2007: Amir Masoud Sadaghiani; Steven H L Verhelst; Vasilena Gocheva; Kimberly Hill; Eva Majerova; Sherman Stinson; Johanna A Joyce; Matthew Bogyo
Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases.
Chemistry & biology 2007;14(5):499-511.
2007: Timo Burster; Thierry Giffon; Martin E Dahl; Pia Björck; Matthew Bogyo; Ekkehard Weber; Kutubuddin Mahmood; David B Lewis; Elizabeth D Mellins
Influenza A virus elevates active cathepsin B in primary murine DC.
International immunology 2007;19(5):645-55.
2007: Kelly B Sexton; Daisuke Kato; Alicia B Berger; Marko Fonovic; Steven H L Verhelst; Matthew Bogyo
Specificity of aza-peptide electrophile activity-based probes of caspases.
Cell death and differentiation 2007;14(4):727-32.
2007: Dominic Cuerrier; Tudor Moldoveanu; Robert L Campbell; Jacqueline Kelly; Bilge Yoruk; Steven H L Verhelst; Doron Greenbaum; Matthew Bogyo; Peter L Davies
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries.
The Journal of biological chemistry 2007;282(13):9600-11.
2007: Kelly B Sexton; Martin D Witte; Galia Blum; Matthew Bogyo
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain.
Bioorganic & medicinal chemistry letters 2007;17(3):649-53.
2007: Amir Masoud Sadaghiani; Steven H L Verhelst; Matthew Bogyo
Tagging and detection strategies for activity-based proteomics.
Current opinion in chemical biology 2007;11(1):20-8.
2007: Chin Fen Teo; Xing W Zhou; Matthew Bogyo; Vernon Bruce Carruthers
Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion.
Antimicrobial agents and chemotherapy 2007;51(2):679-88.
2007: Marko Fonović; Matthew Bogyo
Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening.
Current pharmaceutical design 2007;13(3):253-61.
2007: Steven H L Verhelst; Marko Fonović; Matthew Bogyo
A mild chemically cleavable linker system for functional proteomic applications.
Angewandte Chemie (International ed. in English) 2007;46(8):1284-6.
2006: Alicia B Berger; Kelly B Sexton; Matthew Bogyo
Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity.
Cell research 2006;16(12):961-3.
2006: Amir Masoud Sadaghiani; Steven H L Verhelst; Matthew Bogyo
Solid-phase methods for the preparation of epoxysuccinate-based inhibitors of cysteine proteases.
Journal of combinatorial chemistry 2006;8(6):802-4.
2006: Kailash C Pandey; Naresh Singh; Shirin Arastu-Kapur; Matthew Bogyo; Philip J Rosenthal
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion.
PLoS pathogens 2006;2(11):e117.
2006: Jean-Bernard Denault; Miklós Békés; Fiona L Scott; Kelly M B Sexton; Matthew Bogyo; Guy S Salvesen
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Molecular cell 2006;23(4):523-33.
2006: Alicia B Berger; Martin D Witte; Jean-Bernard Denault; Amir Masoud Sadaghiani; Kelly M B Sexton; Guy S Salvesen; Matthew Bogyo
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
Molecular cell 2006;23(4):509-21.
2006: Steven H L Verhelst; Martin D Witte; Shirin Arastu-Kapur; Marko Fonovic; Matthew Bogyo
Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases.
Chembiochem : a European journal of chemical biology 2006;7(6):943-50.
2006: Zhengying Pan; Douglas A Jeffery; Kareem A H Chehade; Jerlyn Beltman; James M Clark; Paul Grothaus; Matthew Bogyo; Amos Baruch
Development of activity-based probes for trypsin-family serine proteases.
Bioorganic & medicinal chemistry letters 2006;16(11):2882-5.
2006: Olga Vasiljeva; Anna Papazoglou; Achim Krüger; Harald Brodoefel; Matvey Korovin; Jan M Deussing; Nicole Augustin; Boye Nielsen; Kasper Almholt; Matthew Bogyo; Christoph Peters; Thomas Reinheckel
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Cancer research 2006;66(10):5242-50.
2006: Youngchool Choe; Francesco Leonetti; Doron C Greenbaum; Fabien Lecaille; Matthew Bogyo; Dieter Brömme; Jonathan A Ellman; Charles S Craik
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.
The Journal of biological chemistry 2006;281(18):12824-32.
2006: Fang Yuan; Steven H L Verhelst; Galia Blum; Lisa M Coussens; Matthew Bogyo
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.
Journal of the American Chemical Society 2006;128(17):5616-7.
2006: Matthew Bogyo
Metalloproteases see the light.
Nature chemical biology 2006;2(5):229-30.
2005: Daisuke Kato; Steven H L Verhelst; Kelly B Sexton; Matthew Bogyo
A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases.
Organic letters 2005;7(25):5649-52.
2005: Galia Blum; Stefanie R Mullins; Kinneret Keren; Marko Fonovic; Christopher Jedeszko; Mark J Rice; Bonnie F Sloane; Matthew Bogyo
Dynamic imaging of protease activity with fluorescently quenched activity-based probes.
Nature chemical biology 2005;1(4):203-9.
2005: Vivian Y H Hook; Thomas Toneff; Matthew Bogyo; Doron C Greenbaum; Katalin F Medzihradszky; John Neveu; William Stratton Lane; Gregory Hook; Terry Reisine
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.
Biological chemistry 2005;386(9):931-40.
2005: Carolyn I Phillips; Matthew Bogyo
Proteomics meets microbiology: technical advances in the global mapping of protein expression and function.
Cellular microbiology 2005;7(8):1061-76.
2005: Daisuke Kato; Kelly M Boatright; Alicia B Berger; Tamim Nazif; Galia Blum; Ciara Ryan; Kareem A H Chehade; Guy S Salvesen; Matthew Bogyo
Activity-based probes that target diverse cysteine protease families.
Nature chemical biology 2005;1(1):33-8.
2005: Steven H L Verhelst; Matthew Bogyo
Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases.
Chembiochem : a European journal of chemical biology 2005;6(5):824-7.
2005: Steven H L Verhelst; Matthew Bogyo
Chemical proteomics applied to target identification and drug discovery.
BioTechniques 2005;38(2):175-7.
2005: Anna Borodovsky; Huib Ovaa; Wim J N Meester; Emily Venanzi; Matthew Bogyo; Brian G Hekking; Hidde L Ploegh; Benedikt M Kessler; Herman S Overkleeft
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.
Chembiochem : a European journal of chemical biology 2005;6(2):287-91.
2005: Matthew Bogyo
Screening for selective small molecule inhibitors of the proteasome using activity-based probes.
Methods in enzymology 2005;399():609-22.
2004: Scott J Snipas; Eric Wildfang; Tamim Nazif; Leif Christensen; Kelly M Boatright; Matthew Bogyo; Henning Stennicke; Guy S Salvesen
Characteristics of the caspase-like catalytic domain of human paracaspase.
Biological chemistry 2004;385(11):1093-8.
2004: Matthew Bogyo; Amos Baruch; Douglas A Jeffery; Doron Greenbaum; Anna Borodovsky; Huib Ovaa; Benedikt Kessler
Applications for chemical probes of proteolytic activity.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 21():Unit 21.17.
2004: Yoshiyuki Yasuda; Zhenqiang Li; Doron Greenbaum; Matthew Bogyo; Ekkehard Weber; Dieter Brömme
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.
The Journal of biological chemistry 2004;279(35):36761-70.
2004: Renier A L Van der Hoorn; Michiel A Leeuwenburgh; Matthew Bogyo; Matthieu H A J Joosten; Scott C Peck
Activity profiling of papain-like cysteine proteases in plants.
Plant physiology 2004;135(3):1170-8.
2004: Saliha Eksi; Beata Czesny; Doron C Greenbaum; Matthew Bogyo; Kim C Williamson
Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth.
Molecular microbiology 2004;53(1):243-50.
2004: Aneta Oleksy; Ewa Golonka; Agnieszka Bańbuła; Grzegorz Szmyd; Jonathan Moon; Malgorzata Kubica; Doron Greenbaum; Matthew Bogyo; Timothy J Foster; James Travis; Jan Potempa
Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis.
Biological chemistry 2004;385(6):525-35.
2004: Vivian Y H Hook; Sukkid Yasothornsrikul; Doron C Greenbaum; Katalin F Medzihradszky; Katie Troutner; Thomas Toneff; Richard Bundey; Anna Logrinova; Thomas Reinheckel; Christoph Peters; Matthew Bogyo
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones.
Biological chemistry 2004;385(6):473-80.
2004: Johanna A Joyce; Amos Baruch; Kareem A H Chehade; Nicole Meyer-Morse; Enrico Giraudo; Fong-Ying Tsai; Doron C Greenbaum; Jeffrey H Hager; Matthew Bogyo; Douglas Hanahan
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
Cancer cell 2004;5(5):443-53.
2004: Katalin F Medzihradszky; Zsuzsanna Darula; Eran Perlson; Mike Fainzilber; Robert J Chalkley; Haydn Ball; Doron C Greenbaum; Matthew Bogyo; Darren R Tyson; Ralph A Bradshaw; Al L Burlingame
O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes.
Molecular & cellular proteomics : MCP 2004;3(5):429-40.
2004: Brigitte Goulet; Amos Baruch; Nam-Sung Moon; Madeleine Poirier; Laurent Sansregret; Ann H Erickson; Matthew Bogyo; Alain Nepveu
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.
Molecular cell 2004;14(2):207-19.
2004: Zhenqiang Li; Yoshiyuki Yasuda; Weijie Li; Matthew Bogyo; Norman Katz; Ronald E Gordon; Gregg Fields; Dieter Brömme
Regulation of collagenase activities of human cathepsins by glycosaminoglycans.
The Journal of biological chemistry 2004;279(7):5470-9.
2004: Douglas A Jeffery; Matthew Bogyo
Chemical proteomics and its application to drug discovery.
Drug discovery today 2004;9(2 Suppl):S19-26.
2004: Alicia B Berger; Phillip M Vitorino; Matthew Bogyo
Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2004;4(6):371-81.
2004: Amos Baruch; Douglas A Jeffery; Matthew Bogyo
Enzyme activity--it's all about image.
Trends in cell biology 2004;14(1):29-35.
2003: Mohammed Sajid; James H McKerrow; Elizabeth Hansell; Mary A Mathieu; Kimberley D Lucas; Ivy Hsieh; Doron C Greenbaum; Matthew Bogyo; Jason P Salter; Kee-Chong Lim; Christopher Franklin; Jea-Hyoun Kim; Conor R Caffrey
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.
Molecular and biochemical parasitology 2003;131(1):65-75.
2003: Sukkid Yasothornsrikul; Doron C Greenbaum; Katalin F Medzihradszky; Thomas Toneff; Richard Bundey; Ruthellen Miller; Birgit Schilling; Ivonne Petermann; Jessica Dehnert; Anna Logvinova; Paul Goldsmith; John Neveu; William Stratton Lane; Bradford Gibson; Thomas Reinheckel; Christoph Peters; Matthew Bogyo; Vivian Y H Hook
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9590-5.
2003: J Rozman-Pungercar; Natasa Kopitar-Jerala; Matthew Bogyo; Dusan Turk; Olga Vasiljeva; Ivica Stefe; P Vandenabeele; Dieter Brömme; Vida Puizdar; M Fonović; M Trstenjak-Prebanda; Iztok Dolenc; Vito Turk; Boris Turk
Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.
Cell death and differentiation 2003;10(8):881-8.
2003: Ching C Wang; Zbynek Bozdech; Chao-Lin LIU; Aaron Shipway; Bradley J Backes; Jennifer L Harris; Matthew Bogyo
Biochemical analysis of the 20 S proteasome of Trypanosoma brucei.
The Journal of biological chemistry 2003;278(18):15800-8.
2003: Jowita Mikolajczyk; Kelly M Boatright; Henning Stennicke; Tamim Nazif; Jan Potempa; Matthew Bogyo; Guy S Salvesen
Sequential autolytic processing activates the zymogen of Arg-gingipain.
The Journal of biological chemistry 2003;278(12):10458-64.
2003: Benedikt Kessler; Xu Hong; Jelena Petrovic; Anna Borodovsky; Nico P Dantuma; Matthew Bogyo; Herman S Overkleeft; Hidde L Ploegh; Rickard Glas
Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.
The Journal of biological chemistry 2003;278(12):10013-21.
2003: Douglas A Jeffery; Matthew Bogyo
Chemical proteomics and its application to drug discovery.
Current opinion in biotechnology 2003;14(1):87-95.
2002: Doron C Greenbaum; Amos Baruch; Munira Grainger; Zbynek Bozdech; Katalin F Medzihradszky; Juan Engel; Joe L DeRisi; Anthony A Holder; Matthew Bogyo
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite.
Science (New York, N.Y.) 2002;298(5600):2002-6.
2002: Doron C Greenbaum; William D Arnold; Felice Lu; Linda Hayrapetian; Amos Baruch; Jennifer R. Krumrine; Samuel Toba; Kareem A H Chehade; Dieter Brömme; Irwin D Kuntz; Matthew Bogyo
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.
Chemistry & biology 2002;9(10):1085-94.
2002: Michael Groll; Tamim Nazif; Robert Huber; Matthew Bogyo
Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.
Chemistry & biology 2002;9(5):655-62.
2002: Mary A Mathieu; Matthew Bogyo; Conor R Caffrey; Youngchool Choe; Jewok Lee; Harold Chapman; Mohammed Sajid; Charles S Craik; James H McKerrow
Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
Molecular and biochemical parasitology 2002;121(1):99-105.
2002: Doron C Greenbaum; Amos Baruch; Linda Hayrapetian; Zsuzsanna Darula; Al L Burlingame; Katalin F Medzihradszky; Matthew Bogyo
Chemical approaches for functionally probing the proteome.
Molecular & cellular proteomics : MCP 2002;1(1):60-8.
2002: Matthew Bogyo; Evelyn W Wang
Proteasome inhibitors: complex tools for a complex enzyme.
Current topics in microbiology and immunology 2002;268():185-208.
2001: Conor R Caffrey; Elizabeth Hansell; Kimberley D Lucas; Linda S Brinen; Alejandro Alvarez-Hernandez; J Cheng; S L Gwaltney; William R Roush; Y D Stierhof; Matthew Bogyo; Dietmar Steverding; James H McKerrow
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
Molecular and biochemical parasitology 2001;118(1):61-73.
2001: Amos Baruch; Doron C Greenbaum; E T Levy; Peter A Nielsen; Norton B Gilula; Nalin M Kumar; Matthew Bogyo
Defining a link between gap junction communication, proteolysis, and cataract formation.
The Journal of biological chemistry 2001;276(31):28999-9006.
2001: Tamim Nazif; Matthew Bogyo
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):2967-72.
2000: Evelyn W Wang; Benedikt M Kessler; Anna Borodovsky; Benjamin F Cravatt; Matthew Bogyo; Hidde L Ploegh; Rickard Glas
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9990-5.
2000: Doron C Greenbaum; Katalin F Medzihradszky; Al L Burlingame; Matthew Bogyo
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.
Chemistry & biology 2000;7(8):569-81.
2000: Conor R Caffrey; Mary A Mathieu; A M Gaffney; Jason P Salter; Mohammed Sajid; Kimberley D Lucas; Christopher Franklin; Matthew Bogyo; James H McKerrow
Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris.
FEBS letters 2000;466(2-3):244-8.
2000: Matthew Bogyo; Steven H L Verhelst; V Bellingard-Dubouchaud; Samuel Toba; Doron C Greenbaum
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs.
Chemistry & biology 2000;7(1):27-38.
1999: PM Selzer; Sabine Pingel; Ivy Hsieh; B Ugele; VJ Chan; Juan C Engel; Matthew Bogyo; D G Russell; Judy A Sakanari; James H McKerrow
Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11015-22.
1998: Matthew Bogyo; S Shin; JS McMaster; Hidde L Ploegh
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes.
Chemistry & biology 1998;5(6):307-20.
1998: Rickard Glas; Matthew Bogyo; JS McMaster; Maria Gaczynska; Hidde L Ploegh
A proteolytic system that compensates for loss of proteasome function.
Nature 1998;392(6676):618-22.
1998: Andreas Ruepp; Christoph Eckerskorn; Matthew Bogyo; Wolfgang Baumeister
Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum.
FEBS letters 1998;425(1):87-90.
1997: Matthew Bogyo; JS McMaster; Maria Gaczynska; Domenico Tortorella; Alfred L Goldberg; Hidde L Ploegh
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6629-34.
1997: Matthew Bogyo; Maria Gaczynska; Hidde L Ploegh
Proteasome inhibitors and antigen presentation.
Biopolymers 1997;43(4):269-80.
1996: E J Wiertz; Domenico Tortorella; Matthew Bogyo; J Yu; Walther Mothes; T R Jones; Tom A Rapoport; Hidde L Ploegh
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
Nature 1996;384(6608):432-8.
1996: E J Wiertz; T R Jones; L Sun; Matthew Bogyo; H J Geuze; Hidde L Ploegh
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.
Cell 1996;84(5):769-79.