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Christian Spahn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Ribosomes

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Chemicals & Drugs

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Publications

TOP 3
Spahn Christian M T; Penczek Pawel A
Exploring conformational modes of macromolecular assemblies by multiparticle cryo-EM.
Munro James B; Sanbonmatsu Kevin Y; Spahn Christian M T; Blanchard Scott C
Navigating the ribosome's metastable energy landscape.
Schuette Jan-Christian; Murphy Frank V; Kelley Ann C; Weir John R; Giesebrecht Jan; Connell Sean R; Loerke Justus; Mielke Thorsten; Zhang Wei; Penczek Pawel A; Ramakrishnan V; Spahn Christian M T
GTPase activation of elongation factor EF-Tu by the ribosome during decoding.

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All Publications

2009: Spahn Christian M T; Penczek Pawel A
Exploring conformational modes of macromolecular assemblies by multiparticle cryo-EM.
Current opinion in structural biology 2009;19(5):623-31.
2009: Munro James B; Sanbonmatsu Kevin Y; Spahn Christian M T; Blanchard Scott C
Navigating the ribosome's metastable energy landscape.
Trends in biochemical sciences 2009;34(8):390-400.
2009: Schuette Jan-Christian; Murphy Frank V; Kelley Ann C; Weir John R; Giesebrecht Jan; Connell Sean R; Loerke Justus; Mielke Thorsten; Zhang Wei; Penczek Pawel A; Ramakrishnan V; Spahn Christian M T
GTPase activation of elongation factor EF-Tu by the ribosome during decoding.
The EMBO journal 2009;28(6):755-65.
2008: Connell Sean R; Topf Maya; Qin Yan; Wilson Daniel N; Mielke Thorsten; Fucini Paola; Nierhaus Knud H; Spahn Christian M T
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.
Nature structural & molecular biology 2008;15(9):910-5.
2008: Harms Joerg M; Wilson Daniel N; Schluenzen Frank; Connell Sean R; Stachelhaus Torsten; Zaborowska Zaneta; Spahn Christian M T; Fucini Paola
Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.
Molecular cell 2008;30(1):26-38.
2008: Chen James Z; Sachse Carsten; Xu Chen; Mielke Thorsten; Spahn Christian M T; Grigorieff Nikolaus
A dose-rate effect in single-particle electron microscopy.
Journal of structural biology 2008;161(1):92-100.
2007: Connell Sean R; Takemoto Chie; Wilson Daniel N; Wang Hongfei; Murayama Kazutaka; Terada Takaho; Shirouzu Mikako; Rost Maximilian; Schüler Martin; Giesebrecht Jan; Dabrowski Marylena; Mielke Thorsten; Fucini Paola; Yokoyama Shigeyuki; Spahn Christian M T
Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.
Molecular cell 2007;25(5):751-64.
2006: Schüler Martin; Connell Sean R; Lescoute Aurelie; Giesebrecht Jan; Dabrowski Marylena; Schroeer Birgit; Mielke Thorsten; Penczek Pawel A; Westhof Eric; Spahn Christian M T
Structure of the ribosome-bound cricket paralysis virus IRES RNA.
Nature structural & molecular biology 2006;13(12):1092-6.
2006: Andersen Christian B F; Becker Thomas; Blau Michael; Anand Monika; Halic Mario; Balar Bharvi; Mielke Thorsten; Boesen Thomas; Pedersen Jan Skov; Spahn Christian M T; Kinzy Terri Goss; Andersen Gregers R; Beckmann Roland
Structure of eEF3 and the mechanism of transfer RNA release from the E-site.
Nature 2006;443(7112):663-8.
2006: Hofmann Klaus Peter; Spahn Christian M T; Heinrich Reinhart; Heinemann Udo
Building functional modules from molecular interactions.
Trends in biochemical sciences 2006;31(9):497-508.
2006: Penczek Pawel A; Frank Joachim; Spahn Christian M T
A method of focused classification, based on the bootstrap 3D variance analysis, and its application to EF-G-dependent translocation.
Journal of structural biology 2006;154(2):184-94.
2006: Penczek Pawel A; Yang Chao; Frank Joachim; Spahn Christian M T
Estimation of variance in single-particle reconstruction using the bootstrap technique.
Journal of structural biology 2006;154(2):168-83.
2005: Halic Mario; Becker Thomas; Frank Joachim; Spahn Christian M T; Beckmann Roland
Localization and dynamic behavior of ribosomal protein L30e.
Nature structural & molecular biology 2005;12(5):467-8.
2004: Sengupta Jayati; Nilsson Jakob; Gursky Richard; Spahn Christian M T; Nissen Poul; Frank Joachim
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.
Nature structural & molecular biology 2004;11(10):957-62.
2004: Spahn Christian M T; Jan Eric; Mulder Anke; Grassucci Robert A; Sarnow Peter; Frank Joachim
Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor.
Cell 2004;118(4):465-75.
2004: Agrawal Rajendra K; Sharma Manjuli R; Kiel Michael C; Hirokawa Go; Booth Timothy M; Spahn Christian M T; Grassucci Robert A; Kaji Akira; Frank Joachim
Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):8900-5.
2004: Spahn Christian M T; Gomez-Lorenzo Maria G; Grassucci Robert A; Jørgensen Rene; Andersen Gregers R; Beckmann Roland; Penczek Pawel A; Ballesta Juan P G; Frank Joachim
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
The EMBO journal 2004;23(5):1008-19.
2004: Halic Mario; Becker Thomas; Pool Martin R; Spahn Christian M T; Grassucci Robert A; Frank Joachim; Beckmann Roland
Structure of the signal recognition particle interacting with the elongation-arrested ribosome.
Nature 2004;427(6977):808-14.
2004: Spahn Christian M T; Lehrach Hans; Jungblut Peter R
A European focus on proteomics.
Genome biology 2004;5(5):322.
2003: Moccia Robert; Chen Dillon; Lyles Vlasta; Kapuya Estreya; E Yaping; Kalachikov Sergey; Spahn Christian M T; Frank Joachim; Kandel Eric R; Barad Mark; Martin Kelsey C
An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(28):9409-17.
2002: Gao Haixiao; Spahn Christian M T; Grassucci Robert A; Frank Joachim
An assay for local quality in cryo-electron micrographs of single particles.
Ultramicroscopy 2002;93(2):169-78.
2002: Schäfer Markus A; Tastan A Ozlem; Patzke Sebastian; Blaha Gregor; Spahn Christian M T; Wilson Daniel N; Nierhaus Knud H
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit.
The Journal of biological chemistry 2002;277(21):19095-105.
2001: Spahn C M; Beckmann R; Eswar N; Penczek P A; Sali A; Blobel G; Frank J
Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions.
Cell 2001;107(3):373-86.
2001: Beckmann R; Spahn C M; Eswar N; Helmers J; Penczek P A; Sali A; Frank J; Blobel G
Architecture of the protein-conducting channel associated with the translating 80S ribosome.
Cell 2001;107(3):361-72.
2001: Spahn C M; Blaha G; Agrawal R K; Penczek P; Grassucci R A; Trieber C A; Connell S R; Taylor D E; Nierhaus K H; Frank J
Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance.
Molecular cell 2001;7(5):1037-45.
2001: Spahn C M; Kieft J S; Grassucci R A; Penczek P A; Zhou K; Doudna J A; Frank J
Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit.
Science (New York, N.Y.) 2001;291(5510):1959-62.
2001: Beckmann R; Spahn C M; Frank J; Blobel G
The active 80S ribosome-Sec61 complex.
Cold Spring Harbor symposia on quantitative biology 2001;66():543-54.
2000: Diedrich G; Spahn C M; Stelzl U; Schäfer M A; Wooten T; Bochkariov D E; Cooperman B S; Traut R R; Nierhaus K H
Ribosomal protein L2 is involved in the association of the ribosomal subunits, tRNA binding to A and P sites and peptidyl transfer.
The EMBO journal 2000;19(19):5241-50.
2000: Spahn C M; Penczek P A; Leith A; Frank J
A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome.
Structure (London, England : 1993) 2000;8(9):937-48.
2000: Agrawal R K; Spahn C M; Penczek P; Grassucci R A; Nierhaus K H; Frank J
Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle.
The Journal of cell biology 2000;150(3):447-60.
2000: Gomez-Lorenzo M G; Spahn C M; Agrawal R K; Grassucci R A; Penczek P; Chakraburtty K; Ballesta J P; Lavandera J L; Garcia-Bustos J F; Frank J
Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution.
The EMBO journal 2000;19(11):2710-8.
2000: Stelzl U; Spahn C M; Nierhaus K H
Selecting rRNA binding sites for the ribosomal proteins L4 and L6 from randomly fragmented rRNA: application of a method called SERF.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4597-602.
2000: Gabashvili I S; Agrawal R K; Spahn C M; Grassucci R A; Svergun D I; Frank J; Penczek P
Solution structure of the E. coli 70S ribosome at 11.5 A resolution.
Cell 2000;100(5):537-49.
2000: Stelzl U; Spahn C M; Nierhaus K H
RNA-protein interactions in ribosomes: in vitro selection from randomly fragmented rRNA.
Methods in enzymology 2000;318():251-68.
2000: Blaha G; Stelzl U; Spahn C M; Agrawal R K; Frank J; Nierhaus K H
Preparation of functional ribosomal complexes and effect of buffer conditions on tRNA positions observed by cryoelectron microscopy.
Methods in enzymology 2000;317():292-309.
2000: Triana-Alonso F J; Spahn C M; Burkhardt N; Röhrdanz B; Nierhaus K H
Experimental prerequisites for determination of tRNA binding to ribosomes from Escherichia coli.
Methods in enzymology 2000;317():261-76.
1999: Spahn C M; Grassucci R A; Penczek P; Frank J
Direct three-dimensional localization and positive identification of RNA helices within the ribosome by means of genetic tagging and cryo-electron microscopy.
Structure (London, England : 1993) 1999;7(12):1567-73.
1998: Dabrowski M; Spahn C M; Schäfer M A; Patzke S; Nierhaus K H
Protection patterns of tRNAs do not change during ribosomal translocation.
The Journal of biological chemistry 1998;273(49):32793-800.
1998: Spahn C M; Nierhaus K H
Models of the elongation cycle: an evaluation.
Biological chemistry 1998;379(7):753-72.
1998: Burkhardt N; Jünemann R; Spahn C M; Nierhaus K H
Ribosomal tRNA binding sites: three-site models of translation.
Critical reviews in biochemistry and molecular biology 1998;33(2):95-149.
1997: Nierhaus K H; Jünemann R; Spahn C M
Are the current three-site models valid descriptions of the ribosomal elongation cycle?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10499-500.
1996: Spahn C M; Schäfer M A; Krayevsky A A; Nierhaus K H
Conserved nucleotides of 23 S rRNA located at the ribosomal peptidyltransferase center.
The Journal of biological chemistry 1996;271(51):32857-62.
1996: Spahn C M; Remme J; Schäfer M A; Nierhaus K H
Mutational analysis of two highly conserved UGG sequences of 23 S rRNA from Escherichia coli.
The Journal of biological chemistry 1996;271(51):32849-56.
1996: Dabrowski M; Junemann R; Schafer M A; Spahn C M; Nierhaus K H; Alekseeva E V; Dontsova O A; Shpanchenko O V; Bogdanov A A
[Phosphate sites of RNA-ligands interacting with ribosome at different stages of translation. Thiophosphate method of analysis]
Biokhimii?a (Moscow, Russia) 1996;61(11):1971-83.
1996: Meyer H A; Triana-Alonso F; Spahn C M; Twardowski T; Sobkiewicz A; Nierhaus K H
Effects of antisense DNA against the alpha-sarcin stem-loop structure of the ribosomal 23S rRNA.
Nucleic acids research 1996;24(20):3996-4002.
1995: Nierhaus K H; Beyer D; Dabrowski M; Schäfer M A; Spahn C M; Wadzack J; Bittner J U; Burkhardt N; Diedrich G; Jünemann R
The elongating ribosome: structural and functional aspects.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):1011-21.
1995: Dabrowski M; Spahn C M; Nierhaus K H
Interaction of tRNAs with the ribosome at the A and P sites.
The EMBO journal 1995;14(19):4872-82.
1990: Kutay U R; Spahn C M; Nierhaus K H
Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA.
Biochimica et biophysica acta 1990;1050(1-3):193-6.

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Christian Spahn

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Anatomy

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