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Rainer Spanagel

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Hamid R Noori; Rainer Spanagel
Quantum modeling of common sense.
Marcus W Meinhardt; Stephanie Perreau-Lenz; Rainer Spanagel; Oliver Stählin; Christina Bauder-Wenz; Karla U Drescher; Anita C Hansson; Clive Harper; Markus Heilig; Wolfgang H Sommer
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.
Ainhoa Bilbao; Eduardo Blanco; Emilio Fernández-Espejo; María Jesús Luque-Rojas; Ana Palomino; Pedro Araos; Francisco Javier Bermúdez-Silva; Rainer Spanagel; Juan Suárez; Margarita Vida; Fernando Rodríguez de Fonseca
Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism.

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All Publications

2013: Hamid R Noori; Rainer Spanagel
Quantum modeling of common sense.
The Behavioral and brain sciences 2013;36(3):302.
2013: Marcus W Meinhardt; Stephanie Perreau-Lenz; Rainer Spanagel; Oliver Stählin; Christina Bauder-Wenz; Karla U Drescher; Anita C Hansson; Clive Harper; Markus Heilig; Wolfgang H Sommer
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(7):2794-806.
2013: Ainhoa Bilbao; Eduardo Blanco; Emilio Fernández-Espejo; María Jesús Luque-Rojas; Ana Palomino; Pedro Araos; Francisco Javier Bermúdez-Silva; Rainer Spanagel; Juan Suárez; Margarita Vida; Fernando Rodríguez de Fonseca
Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism.
Addiction biology 2013;18(1):78-87.
2013: Wolfgang Sommer; Rainer Spanagel
Behavioral neurobiology of alcohol addiction. Preface.
Current topics in behavioral neurosciences 2013;13():v-vii.
2013: Valentina Vengeliene; Hamid R Noori; Rainer Spanagel
The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats.
Alcoholism, clinical and experimental research 2013;37 Suppl 1():E322-8.
2013: Rainer Spanagel; Valentina Vengeliene
New pharmacological treatment strategies for relapse prevention.
Current topics in behavioral neurosciences 2013;13():583-609.
2012: Hamid R Noori; Ines Brand; Sarah Fliegel; Rainer Spanagel
The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis.
Synapse (New York, N.Y.) 2012;66(10):893-901.
2012: Andrea Schmitt; Rainer Spanagel; Sven P Wichert; Mathias Zink; Thomas Arzberger; Pascal F Durrenberger; Peter Falkai; Mario Herrera-Marschitz; Hans Kretzschmar; Fernando Leonardi-Essmann; Richard Reynolds; Moritz J Rossner; Peter J Gebicke-Haerter
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
European archives of psychiatry and clinical neuroscience 2012;262(7):565-77.
2012: Hamid R Noori; Rainer Spanagel; Anita C Hansson
Neurocircuitry for modeling drug effects.
Addiction biology 2012;17(5):827-64.
2012: Jan Frölich; Tobias Banaschewski; Manfred Döpfner; Rainer Spanagel; Gerd Lehmkuhl
[The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents].
Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 2012;40(5):287-99; quiz 299-300.
2012: Stéphanie Perreau-Lenz; Valentina Vengeliene; Mauro A Corsi; Corrado Corti; Emilio V Merlo-Pich; Hamid R Noori; Rainer Spanagel
Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(9):2121-31.
2012: Stefan M Berger; Sarah E Gartside; Peter Gass; Laurence Lanfumey; Christiane Maser-Gluth; Stephanie Perreau-Lenz; Rainer Spanagel; Miriam A Vogt; Tillmann Weber; Dusan Bartsch
A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(9):1986-98.
2012: Rose-Marie Karlsson; David M Lovinger; Anna Molander; Stephanie Perreau-Lenz; Erick Singley; Matthew Solomon; Rainer Spanagel; Kohichi Tanaka; Louise Adermark; Andrew Holmes; Markus Heilig
Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.
Neuropharmacology 2012;63(2):181-9.
2012: Derik Hermann; Mareen Hoerst; Falk Kiefer; Bertram Krumm; Karl Mann; Stephanie Perreau-Lenz; Alexander Sartorius; Gabriele Ende; Ulrich Frischknecht; Anita C Hansson; Rainer Spanagel; Nuran Tunc-Skarka; Wolfgang Weber-Fahr; Wolfgang Sommer
Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats.
Biological psychiatry 2012;71(11):1015-21.
2012: Dragos Inta; Stephanie Perreau-Lenz; Natascha Pfeiffer; Miriam Schneider; Rainer Spanagel; Miriam A Vogt; Sonja M Wojcik; Peter Gass
Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1.
Behavioural brain research 2012;228(2):328-32.
2012: Frauke Nees; Christopher J Patrick; Tomas Paus; Jean-Baptiste Poline; Luise Poustka; Marcella Rietschel; Trevor W Robbins; Gunter Schumann; Michael N Smolka; Rainer Spanagel; Sabina Steiner; Maren Struve; Jelka Tzschoppe; Sabine Vollstädt-Klein; Eric Artiges; Tobias Banaschewski; Gareth J Barker; Christian Büchel; Patricia J Conrod; Herta Flor; Jürgen Gallinat; Hugh Garavan; Andreas Heinz; Mark Lathrop; Eva Loth; Karl Mann
Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(4):986-95.
2012: Anna Molander; Jan M Deussing; Markus Heilig; Valentina Vengeliene; Wolfgang Wurst; Rainer Spanagel
Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(4):1047-56.
2012: Peggy Schneider; Nina Schweinfurth; Rainer Spanagel; Wolfgang Weber-Fahr; Ying-Jui Ho; Alexander Sartorius; Cornelius R Pawlak
Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge.
Brain, behavior, and immunity 2012;26(2):277-83.
2012: Theresa Brand; Rainer Spanagel; Miriam Schneider
Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling.
PloS one 2012;7(2):e31169.
2011: Rainer Spanagel
Why do we take drugs? From the drug-reinforcement theory to a novel concept of drug instrumentalization.
The Behavioral and brain sciences 2011;34(6):322.
2011: Sandra Helinski; Rainer Spanagel
Publication trends in addiction research.
Addiction biology 2011;16(4):532-9.
2011: Li Dong; Richard Henriksson; Mark Lathrop; Manfred Laucht; Fernando Leonardi-Essmann; Anbarasu Lourdusamy; Stephanie Perreau-Lenz; Monika Ridinger; Marcella Rietschel; Michael N Smolka; Michael Soyka; Rainer Spanagel; Jens Treutlein; Stephanie Witt; Norbert Wodarz; Tatjana Yakovleva; Peter Zill; Urs Albrecht; Georgy Bakalkin; Ainhoa Bilbao; Dorothea Blomeyer; Sven Cichon; Toni-Kim Clarke; Sylvane Desrivieres; Gunter Schumann
Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking.
The American journal of psychiatry 2011;168(10):1090-8.
2011: Falk Kiefer; T Lemenager; A Batra; M Berner; Sven Cichon; J Frank; A Heinz; Markus M Nöthen; A Richter; Marcella Rietschel; M N Smolka; Rainer Spanagel; Jens Treutlein; Klaus Wiedemann; Stephanie Witt; N Wodarz; U S Zimmermann; K Mann
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.
The pharmacogenomics journal 2011;11(5):368-74.
2011: B D Karrenbauer; C P Müller; Ying-Jui Ho; J P Huston; Rainer K W Schwarting; Rainer Spanagel; Cornelius R Pawlak
Time-dependent in-vivo effects of interleukin-2 on neurotransmitters in various cortices: relationships with depressive-related and anxiety-like behaviour.
Journal of neuroimmunology 2011;237(1-2):23-32.
2011: Matthias Klugmann; Viktoria Klippenstein; F Markus Leweke; Rainer Spanagel; Miriam Schneider
Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2011;14(4):505-17.
2011: Andrea Schmitt; Fernando Leonardi-Essmann; Pascal F Durrenberger; Eleni Parlapani; Thomas Schneider-Axmann; Rainer Spanagel; Thomas Arzberger; Hans A Kretzschmar; Mario Herrera-Marschitz; Oliver Gruber; Richard Reynolds; Peter Falkai; Peter J Gebicke-Haerter
Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2011;12(3):201-15.
2011: Peggy Schneider; Rainer Spanagel; Ying-Jui Ho; Cornelius Rainer Pawlak
A novel elevated plus-maze procedure to avoid the one-trial tolerance problem.
Frontiers in behavioral neuroscience 2011;5():43.
2010: Gunter Schumann; E Loth; Tobias Banaschewski; A Barbot; G Barker; C Büchel; Patricia J Conrod; J W Dalley; H Flor; J Gallinat; H Garavan; Andreas Heinz; B Itterman; Mark Lathrop; C Mallik; Karl Mann; J-L Martinot; T Paus; J-B Poline; Trevor W Robbins; Marcella Rietschel; L Reed; M Smolka; Rainer Spanagel; C Speiser; D N Stephens; A Ströhle; M Struve
The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology.
Molecular psychiatry 2010;15(12):1128-39.
2010: Valentina Vengeliene; Fernando Leonardi-Essmann; Wolfgang Sommer; Hugh M Marston; Rainer Spanagel
Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats.
Biological psychiatry 2010;68(8):704-11.
2010: Rainer Spanagel; Dusan Bartsch; Bendikt Brors; Norbert Dahmen; Jan Deussing; Roland Eils; Gabriele Ende; Jürgen Gallinat; Peter J Gebicke-Haerter; Andreas Heinz; Falk Kiefer; Willi Jäger; Karl Mann; Franziska Matthäus; Markus Nöthen; Marcella Rietschel; Alexander Sartorius; Günther Schütz; Wolfgang Sommer; Rolf Sprengel; Henrik Walter; Erich Wichmann; Thomas Wienker; Wolfgang Wurst; Andreas Zimmer
An integrated genome research network for studying the genetics of alcohol addiction.
Addiction biology 2010;15(4):369-79.
2010: John C Umhau; Reza Momenan; Melanie L Schwandt; Erick Singley; Mariel Lifshitz; Linda Doty; Lauren J Adams; Valentina Vengeliene; Rainer Spanagel; Yan Zhang; Jun Shen; David T George; Daniel W Hommer; Markus Heilig
Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study.
Archives of general psychiatry 2010;67(10):1069-77.
2010: Irene Brunk; CARLA SANCHIS-SEGURA; Christian Blex; Stéphanie Perreau-Lenz; Ainhoa Bilbao; Rainer Spanagel; Gudrun Ahnert-Hilger
Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization.
Journal of neurochemistry 2010;115(1):234-46.
2010: Martin Novak; Briac Halbout; Eoin C O'Connor; Jan Rodriguez Parkitna; Tian Su; Minqiang Chai; Hans S Crombag; Ainhoa Bilbao; Rainer Spanagel; David N Stephens; Günther Schütz; David Engblom
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(36):11973-82.
2010: Stéphanie Perreau-Lenz; CARLA SANCHIS-SEGURA; Fernando Leonardi-Essmann; Miriam Schneider; Rainer Spanagel
Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010;20(7):509-17.
2010: Jan Rodriguez Parkitna; Ainhoa Bilbao; Claus Rieker; David Engblom; Marcin Piechota; Alfred Nordheim; Rainer Spanagel; Günther Schütz
Loss of the serum response factor in the dopamine system leads to hyperactivity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2427-35.
2010: Rainer Spanagel
A call for systems approaches in addiction research.
Addiction (Abingdon, England) 2010;105(5):791-2; discussion 795-6.
2010: Rainer Spanagel
Are metabotropic glutamate receptors promising targets for the treatment of alcoholism?
Biological psychiatry 2010;67(9):798-9.
2010: Thomas Enkel; Rainer Spanagel; Barbara Vollmayr; Miriam Schneider
Stress triggers anhedonia in rats bred for learned helplessness.
Behavioural brain research 2010;209(1):183-6.
2010: Miriam Schneider; Verena Heise; Rainer Spanagel
Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward.
Behavioural brain research 2010;208(2):466-72.
2010: Thomas Enkel; Donya Gholizadeh; Oliver von Bohlen und Halbach; CARLA SANCHIS-SEGURA; Rene Hurlemann; Rainer Spanagel; Peter Gass; Barbara Vollmayr
Ambiguous-cue interpretation is biased under stress- and depression-like states in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(4):1008-15.
2010: Derek Zieker; Isabel Jenne; Ingmar Koenigsrainer; Marty Zdichavsky; Kay Nieselt; Katharina Buck; Judith Zieker; Stefan Beckert; Jörg Glatzle; Rainer Spanagel; Alfred Koenigsrainer; Hinnak Northoff; Markus Loeffler
Circadian expression of clock- and tumor suppressor genes in human oral mucosa.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;26(2):155-66.
2010: Chris M Friemel; Rainer Spanagel; Miriam Schneider
Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats.
Frontiers in behavioral neuroscience 2010;4():.
2010: Jochen Mutschler; Ainhoa Bilbao; Christoph von der Goltz; Cueneyt Demiralay; Holger Jahn; Klaus Wiedemann; Rainer Spanagel; Falk Kiefer
Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors.
Alcohol and alcoholism (Oxford, Oxfordshire) 2010;45(1):13-6.
2009: Mathias Zink; Gülsemin Araç; Stefanie Th Frank; Peter Gass; Peter J Gebicke-Härter; Rainer Spanagel
Perinatal exposure to alcohol reduces the expression of complexins I and II.
Neurotoxicology and teratology 2009;31(6):400-5.
2009: Valentina Vengeliene; CELERIER Evelyne; Lea Chaskiel; Franco Penzo; Rainer Spanagel
Compulsive alcohol drinking in rodents.
Addiction biology 2009;14(4):384-96.
2009: Manuel Mameli; Briac Halbout; Cyril Creton; David Engblom; Jan Rodriguez Parkitna; Rainer Spanagel; Christian Lüscher
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.
Nature neuroscience 2009;12(8):1036-41.
2009: Christoph von der Goltz; Valentina Vengeliene; Ainhoa Bilbao; Stephanie Perreau-Lenz; Cornelius R Pawlak; Falk Kiefer; Rainer Spanagel
Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories.
Psychopharmacology 2009;205(3):389-97.
2009: Ulrich S Zimmermann; Patricia R Winkelmann; Max Pilhatsch; Josef A Nees; Rainer Spanagel; Katja Schulz
Withdrawal phenomena and dependence syndrome after the consumption of "spice gold".
Deutsches Ärzteblatt international 2009;106(27):464-7.
2009: Jens Treutlein; Sven Cichon; Monika Ridinger; Norbert Wodarz; Michael Soyka; Peter Zill; Wolfgang Maier; Rainald Moessner; Wolfgang Gaebel; Norbert Dahmen; Christoph Fehr; Norbert Scherbaum; Michael Steffens; Kerstin U Ludwig; Josef Frank; H-Erich Wichmann; Stefan Schreiber; Nico Dragano; Wolfgang Sommer; Fernando Leonardi-Essmann; Anbarasu Lourdusamy; Peter J Gebicke-Haerter; Thomas F Wienker; Patrick F Sullivan; Markus M Nöthen; Falk Kiefer; Rainer Spanagel; Karl Mann; Marcella Rietschel
Genome-wide association study of alcohol dependence.
Archives of general psychiatry 2009;66(7):773-84.
2009: Stéphanie Perreau-Lenz; Tarek Zghoul; Fernando R de Fonseca; Rainer Spanagel; Ainhoa Bilbao
Circadian regulation of central ethanol sensitivity by the mPer2 gene.
Addiction biology 2009;14(3):253-9.
2009: F Matthäus; V A Smith; A Fogtman; Wolfgang Sommer; F Leonardi-Essmann; A Lourdusamy; M A Reimers; Rainer Spanagel; P J Gebicke-Haerter
Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats.
Pharmacopsychiatry 2009;42 Suppl 1():S118-28.
2009: Rainer Spanagel
Alcoholism: a systems approach from molecular physiology to addictive behavior.
Physiological reviews 2009;89(2):649-705.
2009: Britta D Karrenbauer; Ying-Jui Ho; Verena Ludwig; Jeanette Löhn; Rainer Spanagel; Rainer K W Schwarting; Cornelius R Pawlak
Time-dependent effects of striatal interleukin-2 on open field behaviour in rats.
Journal of neuroimmunology 2009;208(1-2):10-8.
2008: Ainhoa Bilbao; Jan Rodriguez Parkitna; David Engblom; Stéphanie Perreau-Lenz; CARLA SANCHIS-SEGURA; Miriam Schneider; Witold Konopka; Magdalena Westphal; Gerome Breen; Sylvane Desrivieres; Matthias Klugmann; Camila Guindalini; Homero Vallada; Ronaldo Laranjeira; Fernando Rodriguez de Fonseca; Gunter Schumann; Günther Schütz; Rainer Spanagel
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17549-54.
2008: Valentina Vengeliene; Falk Kiefer; Rainer Spanagel
D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats.
Alcohol and alcoholism (Oxford, Oxfordshire) 2008;43(6):626-9.
2008: Peter Gass; Fernando Leonardi-Essmann; Maha Zueger; Rainer Spanagel; Peter J Gebicke-Haerter
Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice.
Journal of neuroscience research 2008;86(14):3184-93.
2008: Irene Brunk; Christian Blex; CARLA SANCHIS-SEGURA; Jan Sternberg; Stephanie Perreau-Lenz; Ainhoa Bilbao; Heide Hörtnagl; Jens Baron; Judyta Juranek; Gregor Laube; Lutz Birnbaumer; Rainer Spanagel; Gudrun Ahnert-Hilger
Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3736-46.
2008: David Engblom; Ainhoa Bilbao; CARLA SANCHIS-SEGURA; Lionel Dahan; Stéphanie Perreau-Lenz; Bénédicte Balland; Jan Rodriguez Parkitna; Rafael Luján; Briac Halbout; Manuel Mameli; Rosanna Parlato; Rolf Sprengel; Christian Lüscher; Günther Schütz; Rainer Spanagel
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.
Neuron 2008;59(3):497-508.
2008: Frank Wiens; Annette Zitzmann; Marc-André Lachance; Michel Yegles; Fritz Pragst; Friedrich M Wurst; Dietrich von Holst; Saw Leng Guan; Rainer Spanagel
Chronic intake of fermented floral nectar by wild treeshrews.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10426-31.
2008: Gunter Schumann; Monika Johann; Josef Frank; Ulrich W Preuss; Norbert Dahmen; Manfred Laucht; Marcella Rietschel; Dan Rujescu; Anbarasu Lourdusamy; Toni-Kim Clarke; Kristina Krause; Anne Dyer; Martin Depner; Stefan Wellek; Jens Treutlein; Armin Szegedi; Ina Giegling; Sven Cichon; Dorothea Blomeyer; Andreas Heinz; Simon Heath; Mark Lathrop; Norbert Wodarz; Michael Soyka; Rainer Spanagel; Karl Mann
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
Archives of general psychiatry 2008;65(7):826-38.
2008: Karl Mann; Falk Kiefer; Rainer Spanagel; John Littleton
Acamprosate: recent findings and future research directions.
Alcoholism, clinical and experimental research 2008;32(7):1105-10.
2008: Hanna Raeder; Sabine M Holter; Annette M Hartmann; Rainer Spanagel; Hans-Juergen Moller; Dan Rujescu
Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administration.
Drug and alcohol dependence 2008;96(1-2):16-21.
2008: Miriam Schneider; Rainer Spanagel
Appetitive odor-cue conditioning attenuates the acoustic startle response in rats.
Behavioural brain research 2008;189(1):226-30.
2008: Gabriele Hampp; Jürgen A Ripperger; Thijs Houben; Isabelle Schmutz; Christian Blex; Stéphanie Perreau-Lenz; Irene Brunk; Rainer Spanagel; Gudrun Ahnert-Hilger; Johanna H Meijer; Urs Albrecht
Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood.
Current biology : CB 2008;18(9):678-83.
2008: Stephanie Perreau-Lenz; Rainer Spanagel
The effects of drugs of abuse on clock genes.
Drug news & perspectives 2008;21(4):211-7.
2008: Valentina Vengeliene; Ainhoa Bilbao; A Molander; Rainer Spanagel
Neuropharmacology of alcohol addiction.
British journal of pharmacology 2008;154(2):299-315.
2008: Stefanie Th Frank; Bertram Krumm; Rainer Spanagel
Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis.
Synapse (New York, N.Y.) 2008;62(4):243-52.
2008: Rainer Spanagel; Falk Kiefer
Drugs for relapse prevention of alcoholism: ten years of progress.
Trends in pharmacological sciences 2008;29(3):109-15.
2008: Cornelius R Pawlak; CARLA SANCHIS-SEGURA; Dian Soewarto; Sibylle Wagner; Martin Hrabé De Angelis; Rainer Spanagel
A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(2):77-84.
2007: Valentina Vengeliene; Christian A Heidbreder; Rainer Spanagel
The effects of lamotrigine on alcohol seeking and relapse.
Neuropharmacology 2007;53(8):951-7.
2007: Stéphanie Perreau-Lenz; Tarek Zghoul; Rainer Spanagel
Clock genes running amok. Clock genes and their role in drug addiction and depression.
EMBO reports 2007;8 Spec No():S20-3.
2007: CARLA SANCHIS-SEGURA; Brandon Cline; Rachel Jurd; Uwe Rudolph; Rainer Spanagel
Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal.
Neuroscience letters 2007;416(3):275-8.
2007: J Zieker; Derek Zieker; A Jatzko; Janko Dietzsch; Kay Nieselt; A Schmitt; T Bertsch; K Fassbender; Rainer Spanagel; H Northoff; Peter J Gebicke-Haerter
Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder.
Molecular psychiatry 2007;12(2):116-8.
2007: Marc W Füllgrabe; Valentina Vengeliene; Rainer Spanagel
Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats.
Pharmacology, biochemistry, and behavior 2007;86(2):320-6.
2007: Miriam Schneider; Rainer Spanagel; Sheng-Jia Zhang; Hilmar Bading; Matthias Klugmann
Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice.
BMC neuroscience 2007;8():105.
2007: Miriam Bottlender; Rainer Spanagel; Michael Soyka
[One drink, one drunk--controlled drinking by alcoholics? 3-year-outcome after intensive outpatient treatment].
Psychotherapie, Psychosomatik, medizinische Psychologie 2007;57(1):32-8.
2007: Tarek Zghoul; Carolina Abarca; CARLA SANCHIS-SEGURA; Urs Albrecht; Gunter Schumann; Rainer Spanagel
Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice.
Psychopharmacology 2007;190(1):13-9.
2006: Valentina Vengeliene; Fernando Leonardi-Essmann; Stéphanie Perreau-Lenz; Peter J Gebicke-Haerter; Karla Drescher; Gerhard Gross; Rainer Spanagel
The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2223-33.
2006: Falk Kiefer; Rainer Spanagel
Measuring alcohol consumption in man--it is time for a change.
Addiction (Abingdon, England) 2006;101(8):1215-6; author reply 1216-7.
2006: Jens Treutlein; C Kissling; J Frank; S Wiemann; L Dong; Martin Depner; Christina Saam; Jesús Lascorz; Michael Soyka; Ulrich W Preuss; Dan Rujescu; Markus H Skowronek; Marcella Rietschel; Rainer Spanagel; Andreas Heinz; Manfred Laucht; Karl Mann; Gunter Schumann
Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.
Molecular psychiatry 2006;11(6):594-602.
2006: CARLA SANCHIS-SEGURA; Rainer Spanagel
Behavioural assessment of drug reinforcement and addictive features in rodents: an overview.
Addiction biology 2006;11(1):2-38.
2006: Rainer Spanagel
Science meets public.
Addiction biology 2006;11(1):1.
2006: Maha Zueger; Alexandre Urani; Sabine Chourbaji; Christiane Zacher; Hans-Peter Lipp; U Albrecht; Rainer Spanagel; David P Wolfer; Peter Gass
mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(3):347-56.
2006: CARLA SANCHIS-SEGURA; Thilo Borchardt; Valentina Vengeliene; Tarek Zghoul; Daniel Bachteler; Peter Gass; Rolf Sprengel; Rainer Spanagel
Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(4):1231-8.
2005: Rainer Spanagel; Markus Heilig
Addiction and its brain science.
Addiction (Abingdon, England) 2005;100(12):1813-22.
2005: Derek Zieker; Elvira Fehrenbach; Janko Dietzsch; Judith Fliegner; Marc Waidmann; Kay Nieselt; Peter J Gebicke-Haerter; Rainer Spanagel; Perikles Simon; Andreas Niess; Hinnak Northoff
cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise.
Physiological genomics 2005;23(3):287-94.
2005: Sabine Chourbaji; Christiane Zacher; CARLA SANCHIS-SEGURA; Rainer Spanagel; Peter Gass
Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice.
Behavioural brain research 2005;164(1):100-6.
2005: Joachim Körkel; Michael Soyka; Miriam Bottlender; Rainer Spanagel
[For and against: controlled drinking as useful and necessary treatment alternative].
Psychiatrische Praxis 2005;32(7):324-6.
2005: Rainer Spanagel; Alan M Rosenwasser; Gunter Schumann; Dipak K Sarkar
Alcohol consumption and the body's biological clock.
Alcoholism, clinical and experimental research 2005;29(8):1550-7.
2005: Soeren Siegmund; Valentina Vengeliene; Manfred V Singer; Rainer Spanagel
Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases.
Alcoholism, clinical and experimental research 2005;29(7):1139-45.
2005: CARLA SANCHIS-SEGURA; Rainer Spanagel; Fritz A Henn; Barbara Vollmayr
Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law.
Behavioural pharmacology 2005;16(4):267-70.
2005: Daniel Bachteler; Daina Economidou; Wojciech Danysz; Roberto Ciccocioppo; Rainer Spanagel
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(6):1104-10.
2005: Tatyana Strekalova; Rainer Spanagel; O Dolgov; Dusan Bartsch
Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice.
Behavioural pharmacology 2005;16(3):171-80.
2005: Valentina Vengeliene; Daniel Bachteler; Wojciech Danysz; Rainer Spanagel
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect.
Neuropharmacology 2005;48(6):822-9.
2005: Mathias Zink; Rainer Spanagel
Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex.
Neuroreport 2005;16(4):377-80.
2005: Valentina Vengeliene; Barbara Vollmayr; Fritz A Henn; Rainer Spanagel
Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior.
Psychopharmacology 2005;178(2-3):125-32.
2005: Fernando Leonardi-Essmann; Michael Emig; Yoshihisa Kitamura; Rainer Spanagel; Peter J Gebicke-Haerter
Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia.
Journal of neuroimmunology 2005;160(1-2):92-101.
2005: Rainer Spanagel; Gurudutt Pendyala; Carolina Abarca; Tarek Zghoul; CARLA SANCHIS-SEGURA; Maria Chiara Magnone; Jesús Lascorz; Martin Depner; David Holzberg; Michael Soyka; Stefan Schreiber; Fumihiko MATSUDA; Mark Lathrop; Gunter Schumann; Urs Albrecht
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.
Nature medicine 2005;11(1):35-42.
2004: Claudia Werner; Gennadij Raivich; Michael S Cowen; Tatyana Strekalova; Inge Sillaber; Jeroen Buters; Rainer Spanagel; Franz Hofmann
Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol.
The European journal of neuroscience 2004;20(12):3498-506.
2004: Mathias Zink; Andrea Schmitt; Valentina Vengeliene; Fritz A Henn; Rainer Spanagel
Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures.
Alcoholism, clinical and experimental research 2004;28(11):1752-7.
2004: Tatyana Strekalova; Rainer Spanagel; Dusan Bartsch; Fritz A Henn; Peter Gass
Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(11):2007-17.
2004: CARLA SANCHIS-SEGURA; Brandon H Cline; Giovanni Marsicano; Beat Lutz; Rainer Spanagel
Reduced sensitivity to reward in CB1 knockout mice.
Psychopharmacology 2004;176(2):223-32.
2004: Karl-Christian Schroff; Michael S Cowen; Sabrina Koch; Rainer Spanagel
Strain-specific responses of inbred mice to ethanol following food shortage.
Addiction biology 2004;9(3-4):265-71.
2004: John M Littleton; Philippe De Witte; Raye Litten; Gian Luigi Gessa; Rainer Spanagel; Henry R Kranzler; Philippe Lehert; Bankole Johnson; John Saunders; Mats Berglund; Adron Harris; Raymond F Anton; Karl Mann
Challenges to medications development in treating alcohol dependence: an international perspective.
Alcohol and alcoholism (Oxford, Oxfordshire) 2004;39(4):271-5.
2004: Pia Bäckström; Daniel Bachteler; Sabrina Koch; Petri Hyytiä; Rainer Spanagel
mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(5):921-8.
2004: Barbara Vollmayr; Daniel Bachteler; Valentina Vengeliene; Peter Gass; Rainer Spanagel; Fritz A Henn
Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning.
Behavioural brain research 2004;150(1-2):217-21.
2003: Gunter Schumann; Dan Rujescu; Christian Kissling; Michael Soyka; Norbert Dahmen; Ulrich W Preuss; Stefan Wieman; Martin Depner; Stefan Wellek; Jesús Lascorz; Brigitta Bondy; Ina Giegling; Ion Anghelescu; Michael S Cowen; Annemarie Poustka; Rainer Spanagel; Karl Mann; Fritz A Henn; Armin Szegedi
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts.
Biological psychiatry 2003;54(12):1422-6.
2003: Alexander Fleischmann; Oivind Hvalby; Vidar Jensen; Tatyana Strekalova; Christiane Zacher; Liliana E Layer; Ane Kvello; Markus Reschke; Rainer Spanagel; Rolf Sprengel; Erwin F Wagner; Peter Gass
Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9116-22.
2003: Michael S Cowen; Karl-Christian Schroff; P Gass; R Sprengel; Rainer Spanagel
Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice.
Neuropharmacology 2003;45(3):325-33.
2003: Michael S Cowen; Gunter Schumann; Takeshi Yagi; Rainer Spanagel
Role of Fyn tyrosine kinase in ethanol consumption by mice.
Alcoholism, clinical and experimental research 2003;27(8):1213-9.
2003: Rainer Spanagel
Alcohol addiction research: from animal models to clinics.
Best practice & research. Clinical gastroenterology 2003;17(4):507-18.
2003: Valentina Vengeliene; Soeren Siegmund; Manfred V Singer; John David Sinclair; Ting-Kai Li; Rainer Spanagel
A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake.
Alcoholism, clinical and experimental research 2003;27(7):1048-54.
2003: Ulrich Kratzer; Rainer Spanagel; Werner J Schmidt
The effect of acamprosate on the development of morphine-induced behavioral sensitization in rats.
Behavioural pharmacology 2003;14(4):351-6.
2003: Véronique Deroche-Gamonet; Inge Sillaber; Bruno Aouizerate; Ryozuke Izawa; Ghassan Jaber; Sandy Ghozland; Christoph Kellendonk; Michel Le Moal; Rainer Spanagel; Günther Schütz; François Tronche; Pier Vincenzo Piazza
The glucocorticoid receptor as a potential target to reduce cocaine abuse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4785-90.
2003: Gunter Schumann; Rainer Spanagel; Karl Mann
Candidate genes for alcohol dependence: animal studies.
Alcoholism, clinical and experimental research 2003;27(5):880-8.
2003: Gunter Schumann; Dan Rujescu; Armin Szegedi; P Singer; S Wiemann; Stefan Wellek; Ina Giegling; Christoph Klawe; I Anghelescu; Andreas Heinz; Rainer Spanagel; K Mann; Fritz A Henn; N Dahmen
No association of alcohol dependence with a NMDA-receptor 2B gene variant.
Molecular psychiatry 2003;8(1):11-2.
2002: Rainer Spanagel; Soeren Siegmund; Michael S Cowen; Karl-Christian Schroff; Gunter Schumann; Magdalena Fiserova; Inge Sillaber; Stefan Wellek; Manfred Singer; Jörg Putzke
The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8676-83.
2002: Carolina Abarca; Urs Albrecht; Rainer Spanagel
Cocaine sensitization and reward are under the influence of circadian genes and rhythm.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):9026-30.
2002: Christian Kirschke; Jan Schadrack; Walter Zieglgänsberger; Rainer Spanagel
Effects of morphine withdrawal on micro-opioid receptor-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate autoradiography in rat brain.
European journal of pharmacology 2002;446(1-3):43-51.
2002: Markus S H Henniger; Rainer Spanagel; Alexandra Wigger; Rainer Landgraf; Sabine M Hölter
Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(6):729-36.
2002: Inge Sillaber; Gerhard Rammes; Stephan Zimmermann; Beatrice Mahal; Walter Zieglgänsberger; Wolfgang Wurst; Florian Holsboer; Rainer Spanagel
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
Science (New York, N.Y.) 2002;296(5569):931-3.
2001: Gerhard Rammes; Beatrice Mahal; J Putzke; C Parsons; P Spielmanns; E Pestel; Rainer Spanagel; Walter Zieglgänsberger; Jan Schadrack
The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801.
Neuropharmacology 2001;40(6):749-60.
2001: Shahnaz Christina Azad; Giovanni Marsicano; I Eberlein; J Putzke; Walter Zieglgänsberger; Rainer Spanagel; Beat Lutz
Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse.
The European journal of neuroscience 2001;13(3):561-8.
2000: Sabine M Hölter; Markus S H Henniger; A W Lipkowski; Rainer Spanagel
Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats.
Psychopharmacology 2000;153(1):93-102.
2000: Markus S H Henniger; frauke ohl; Sabine M Hölter; P Weissenbacher; Nicola Toschi; P Lörscher; Alexandra Wigger; Rainer Spanagel; Rainer Landgraf
Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour.
Behavioural brain research 2000;111(1-2):153-63.
2000: Sabine M Hölter; Astrid C E Linthorst; Johannes M H M Reul; Rainer Spanagel
Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats.
Pharmacology, biochemistry, and behavior 2000;66(1):143-51.
2000: Stefan Platzer; A Winkler; Jan Schadrack; D Dworzak; Thomas R Tölle; Walter Zieglgänsberger; Rainer Spanagel
Autoradiographic distribution of mu-, delta- and kappa 1-opioid stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in human frontal cortex and cerebellum.
Neuroscience letters 2000;283(3):213-6.
2000: Sabine M Hölter; W Danysz; Rainer Spanagel
Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure.
The Journal of pharmacology and experimental therapeutics 2000;292(2):545-52.
2000: Rainer Spanagel; Sabine M Hölter
Pharmacological validation of a new animal model of alcoholism.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(6):669-80.
1999: Rainer Spanagel
Is there a pharmacological basis for therapy with rapid opioid detoxification?
Lancet 1999;354(9195):2017-8.
1999: Rainer Spanagel; F Weiss
The dopamine hypothesis of reward: past and current status.
Trends in neurosciences 1999;22(11):521-7.
1999: A Winkler; Beatrice Mahal; K Kiianmaa; Walter Zieglgänsberger; Rainer Spanagel
Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats.
Brain research. Molecular brain research 1999;72(2):166-75.
1999: Thomas Stoehr; Osborne Almeida; Rainer Landgraf; T S Shippenberg; Florian Holsboer; Rainer Spanagel
Stress- and corticosteroid-induced modulation of the locomotor response to morphine in rats.
Behavioural brain research 1999;103(1):85-93.
1999: Sabine M Hölter; Rainer Spanagel
Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats.
Psychopharmacology 1999;145(4):360-9.
1999: Rainer Spanagel; J Kornhuber
[Glutamate receptor agonists and alcohol dependence. Preclinical findings].
Der Nervenarzt 1999;70(5):479-81.
1999: A Winkler; Beatrice Mahal; Walter Zieglgänsberger; Rainer Spanagel
Accurate quantification of the mRNA of NMDAR1 splice variants measured by competitive RT-PCR.
Brain research. Brain research protocols 1999;4(1):69-81.
1999: Rainer Spanagel; Sabine M Hölter
Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism?
Alcohol and alcoholism (Oxford, Oxfordshire) 1999;34(2):231-43.
1999: Rainer Rupprecht; M Koch; Alexandra Montkowski; Marike Lancel; J Faulhaber; J Harting; Rainer Spanagel
Assessment of neuroleptic-like properties of progesterone.
Psychopharmacology 1999;143(1):29-38.
1999: George F Koob; F Weiss; S T Tiffany; W Zieglgansberger; Rainer Spanagel
Animal models of craving: a roundtable discussion.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 1999;23(3):233-6.
1998: J Putzke; R De Beun; R Schreiber; J De Vry; Thomas R Tölle; Walter Zieglgänsberger; Rainer Spanagel
Long-term alcohol self-administration and alcohol withdrawal differentially modulate microtubule-associated protein 2 (MAP2) gene expression in the rat brain.
Brain research. Molecular brain research 1998;62(2):196-205.
1998: Rainer Spanagel; Christian Kirschke; F Tretter; F Holsboer
Forced opiate withdrawal under anaesthesia augments and prolongs the occurrence of withdrawal signs in rats.
Drug and alcohol dependence 1998;52(3):251-6.
1998: Rainer Spanagel; Inge Sillaber; Walter Zieglgänsberger; W A Corrigall; J Stewart; Yavin Shaham
Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress.
Psychopharmacology 1998;139(4):391-401.
1998: Inge Sillaber; Alexandra Montkowski; Rainer Landgraf; Nicholas Barden; Florian Holsboer; Rainer Spanagel
Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide.
Neuroscience 1998;85(2):415-25.
1998: P Timpl; Rainer Spanagel; Inge Sillaber; Adelheid E Kresse; Johannes M H M Reul; Günter K Stalla; V Blanquet; Thomas Steckler; Florian Holsboer; Wolfgang Wurst
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Nature genetics 1998;19(2):162-6.
1998: A Winkler; Rainer Spanagel
Differences in the kappa opioid receptor mRNA content in distinct brain regions of two inbred mice strains.
Neuroreport 1998;9(7):1459-64.
1998: MB Darstein; C Albrecht; L López-Francos; Rainer Knörle; Sabine M Hölter; Rainer Spanagel; Thomas J Feuerstein
Release and accumulation of neurotransmitters in the rat brain: acute effects of ethanol in vitro and effects of long-term voluntary ethanol intake.
Alcoholism, clinical and experimental research 1998;22(3):704-9.
1998: Wolfgang Hundt; Sabine M Hölter; Rainer Spanagel
Discriminative stimulus effects of glutamate release inhibitors in rats trained to discriminate ethanol.
Pharmacology, biochemistry, and behavior 1998;59(3):691-5.
1998: Sabine M Hölter; Mario Engelmann; Christian Kirschke; G Liebsch; Rainer Landgraf; Rainer Spanagel
Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats.
Behavioural pharmacology 1998;9(1):41-8.
1998: Wolfgang Hundt; W Danysz; Sabine M Hölter; Rainer Spanagel
Ethanol and N-methyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat.
Psychopharmacology 1998;135(1):44-51.
1997: Sabine M Hölter; Rainer Landgraf; Walter Zieglgänsberger; Rainer Spanagel
Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation.
Alcoholism, clinical and experimental research 1997;21(5):862-8.
1997: B Schöbitz; G Pezeshki; JC Probst; Johannes M H M Reul; Thomas Skutella; Thomas Stoehr; Florian Holsboer; Rainer Spanagel
Centrally administered oligodeoxynucleotides in rats: occurrence of non-specific effects.
European journal of pharmacology 1997;331(2-3):97-107.
1997: Rainer Spanagel; Walter Zieglgänsberger
Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes.
Trends in pharmacological sciences 1997;18(2):54-9.
1997: Thomas Skutella; R K Schwarting; J P Huston; Inge Sillaber; JC Probst; Florian Holsboer; Rainer Spanagel
Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour.
The European journal of neuroscience 1997;9(2):210-20.
1996: J Putzke; Rainer Spanagel; Thomas R Tölle; Walter Zieglgänsberger
The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal.
European journal of pharmacology 1996;317(1):39-48.
1996: Sabine M Hölter; W Danysz; Rainer Spanagel
Evidence for alcohol anti-craving properties of memantine.
European journal of pharmacology 1996;314(3):R1-2.
1996: Rainer Spanagel
The influence of opioid antagonists on the discriminative stimulus effects of ethanol.
Pharmacology, biochemistry, and behavior 1996;54(4):645-9.
1996: Rainer Spanagel; Walter Zieglgänsberger; Wolfgang Hundt
Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat.
European journal of pharmacology 1996;305(1-3):51-6.
1996: Rainer Spanagel; J Putzke; Andreas Stefferl; B Schöbitz; Walter Zieglgänsberger
Acamprosate and alcohol: II. Effects on alcohol withdrawal in the rat.
European journal of pharmacology 1996;305(1-3):45-50.
1996: Rainer Spanagel; Sabine M Hölter; K Allingham; Rainer Landgraf; Walter Zieglgänsberger
Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat.
European journal of pharmacology 1996;305(1-3):39-44.
1995: Rainer Spanagel; Alexandra Montkowski; K Allingham; Thomas Stoehr; M Shoaib; Florian Holsboer; Rainer Landgraf
Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats.
Psychopharmacology 1995;122(4):369-73.
1995: Rainer Spanagel
Modulation of drug-induced sensitization processes by endogenous opioid systems.
Behavioural brain research 1995;70(1):37-49.
1995: M Shoaib; Rainer Spanagel; Thomas Stoehr; Toni S Shippenberg
Strain differences in the rewarding and dopamine-releasing effects of morphine in rats.
Psychopharmacology 1995;117(2):240-7.
1994: Rainer Spanagel; M Shoaib
Involvement of mesolimbic kappa-opioid systems in the discriminative stimulus effects of morphine.
Neuroscience 1994;63(3):797-804.
1994: Rainer Spanagel; Osborne Almeida; Toni S Shippenberg
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
European journal of pharmacology 1994;264(2):157-62.
1994: Rainer Spanagel; B Eilbacher; R Wilke
Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat--a pharmacokinetic microdialysis study.
European journal of pharmacology 1994;262(1-2):21-6.
1994: Rainer Spanagel; Osborne Almeida; C Bartl; Toni S Shippenberg
Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release.
Psychopharmacology 1994;115(1-2):121-7.
1994: Thomas Skutella; JC Probst; G F Jirikowski; F Holsboer; Rainer Spanagel
Ventral tegmental area (VTA) injections of tyrosine hydroxylase phosphorothioate antisense oligonucleotide suppress operant behavior in rats.
Neuroscience letters 1994;167(1-2):55-8.
1994: M Shoaib; Rainer Spanagel
Mesolimbic sites mediate the discriminative stimulus effects of morphine.
European journal of pharmacology 1994;252(1):69-75.
1993: Rainer Spanagel; Osborne Almeida; Toni S Shippenberg
Long lasting changes in morphine-induced mesolimbic dopamine release after chronic morphine exposure.
Synapse (New York, N.Y.) 1993;14(3):243-5.
1993: Rainer Spanagel; Toni S Shippenberg
Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat.
Neuroscience letters 1993;153(2):232-6.
1992: Toni S Shippenberg; A Herz; Rainer Spanagel; R Bals-Kubik; C Stein
Conditioning of opioid reinforcement: neuroanatomical and neurochemical substrates.
Annals of the New York Academy of Sciences 1992;654():347-56.
1992: Rainer Spanagel; A Herz; Toni S Shippenberg
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2046-50.
1992: A Herz; Toni S Shippenberg; R Bals-Kubik; Rainer Spanagel
[Opiate addiction. Pharmacologic and biochemical aspects].
Arzneimittel-Forschung 1992;42(2A):256-9.
1991: Rainer Spanagel; A Herz; Toni S Shippenberg
Modulation of the mesolimbic dopaminergic system by beta-endorphin-(1-27) as assessed by microdialysis.
European journal of pharmacology 1991;200(2-3):319-24.
1991: Rainer Spanagel; A Herz; R Bals-Kubik; Toni S Shippenberg
Beta-endorphin-induced locomotor stimulation and reinforcement are associated with an increase in dopamine release in the nucleus accumbens.
Psychopharmacology 1991;104(1):51-6.
1990: Rainer Spanagel; A Herz; Toni S Shippenberg
Identification of the opioid receptor types mediating beta-endorphin-induced alterations in dopamine release in the nucleus accumbens.
European journal of pharmacology 1990;190(1-2):177-84.
1990: Rainer Spanagel; A Herz; Toni S Shippenberg
The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study.
Journal of neurochemistry 1990;55(5):1734-40.