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Thomas Spande

Research Profile

Chemicals & Drugs

Living Beings

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Skin

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TOP 3
Paul J Weldon; Robert K Vander Meer; Yasmin J Cardoza; John W Daly; W Clint Hoffmann; Thomas F Spande
Contact toxicities of anuran skin alkaloids against the fire ant (Solenopsis invicta).
Ralph A Saporito; Roy A Norton; Nirina R Andriamaharavo; Hugo Martin Garraffo; Thomas F Spande
Alkaloids in the mite Scheloribates laevigatus: further alkaloids common to oribatid mites and poison frogs.
Richard W Fitch; Thomas F Spande; H Martin Garraffo; Herman J C Yeh; John W Daly
Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi.

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All Publications

2013: Paul J Weldon; Robert K Vander Meer; Yasmin J Cardoza; John W Daly; W Clint Hoffmann; Thomas F Spande
Contact toxicities of anuran skin alkaloids against the fire ant (Solenopsis invicta).
Die Naturwissenschaften 2013;100(2):185-92.
2011: Ralph A Saporito; Roy A Norton; Nirina R Andriamaharavo; Hugo Martin Garraffo; Thomas F Spande
Alkaloids in the mite Scheloribates laevigatus: further alkaloids common to oribatid mites and poison frogs.
Journal of chemical ecology 2011;37(2):213-8.
2010: Richard W Fitch; Thomas F Spande; H Martin Garraffo; Herman J C Yeh; John W Daly
Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi.
Journal of natural products 2010;73(3):331-7.
2010: Nirina R Andriamaharavo; H Martin Garraffo; Ralph A Saporito; John W Daly; Christian R Razafindrabe; Marta Andriantsiferana; Thomas F Spande
Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats.
Journal of natural products 2010;73(3):322-30.
2010: Tappey H Jones; H Martin Garraffo; Thomas F Spande; Nirina R Andriamaharavo; Jeffrey S T Gorman; Alexander J Snyder; Andrew W Jeter; Juan A Torres; Roy R Snelling; John W Daly
Caste-specific tyramides from Myrmicine ants.
Journal of natural products 2010;73(3):313-6.
2010: Ralph A Saporito; Maureen A Donnelly; Anne A Madden; H Martin Garraffo; Thomas F Spande
Sex-related differences in alkaloid chemical defenses of the dendrobatid frog Oophaga pumilio from Cayo Nancy, Bocas del Toro, Panama.
Journal of natural products 2010;73(3):317-21.
2009: Naoki Toyooka; Dejun Zhou; Hideo Nemoto; Yasuhiro Tezuka; Shigetoshi Kadota; Nirina R Andriamaharavo; H Martin Garraffo; Thomas F Spande; John W Daly
Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B.
The Journal of organic chemistry 2009;74(17):6784-91.
2009: John W Daly; Nathaniel Ware; Ralph A Saporito; Thomas F Spande; H Martin Garraffo
N-methyldecahydroquinolines: an unexpected class of alkaloids from Amazonian poison frogs (Dendrobatidae).
Journal of natural products 2009;72(6):1110-4.
2009: Richard W Fitch; Gordon D Sturgeon; Shaun R Patel; Thomas F Spande; H Martin Garraffo; John W Daly; Richard H Blaauw
Epiquinamide: a poison that wasn't from a frog that was.
Journal of natural products 2009;72(2):243-7.
2008: John W Daly; H Martin Garraffo; Thomas F Spande; Herman J C Yeh; Paola M Peltzer; Pedro M Cacivio; J Diego Baldo; Julián Faivovich
Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus).
Toxicon : official journal of the International Society on Toxinology 2008;52(8):858-70.
2008: Marloes A Wijdeven; Roel Wijtmans; Rutger J F van den Berg; Wim Noorduin; Hans E Schoemaker; Theo Sonke; Floris L van Delft; Richard H Blaauw; Richard W Fitch; Thomas F Spande; John W Daly; Floris P J T Rutjes
N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide.
Organic letters 2008;10(18):4001-3.
2008: John W Daly; H Martin Garraffo; Thomas F Spande; Lesley-Ann Giddings; Ralph A Saporito; David R Vieites; Miguel Vences
Individual and geographic variation of skin alkaloids in three species of Madagascan poison frogs (Mantella).
Journal of chemical ecology 2008;34(2):252-79.
2008: Angela Nelson; H Martin Garraffo; Thomas F Spande; John W Daly; Paul J Stevenson
Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus).
Beilstein journal of organic chemistry 2008;4():6.
2007: Naoki Toyooka; Soushi Kobayashi; Dejun Zhou; Hiroshi Tsuneki; Tsutomu Wada; Hideki Sakai; Hideo Nemoto; Toshiyasu Sasaoka; H Martin Garraffo; Thomas F Spande; John W Daly
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry letters 2007;17(21):5872-5.
2007: Ralph A Saporito; Maureen A Donnelly; Poonam Jain; H Martin Garraffo; Thomas F Spande; John W Daly
Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years.
Toxicon : official journal of the International Society on Toxinology 2007;50(6):757-78.
2007: Ralph A Saporito; Maureen A Donnelly; Roy A Norton; H Martin Garraffo; Thomas F Spande; John W Daly
Oribatid mites as a major dietary source for alkaloids in poison frogs.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8885-90.
2007: John W Daly; Jason Wilham; Thomas F Spande; H Martin Garraffo; Roberto R Gil; Gloria L Silva; M Vaira
Alkaloids in bufonid toads (melanophryniscus): temporal and geographic determinants for two argentinian species.
Journal of chemical ecology 2007;33(4):871-87.
2007: Tappey H Jones; Heather L Voegtle; Heather M Miras; Robert G Weatherford; Thomas F Spande; H Martin Garraffo; John W Daly; Diane W Davidson; Roy R Snelling
Venom chemistry of the ant Myrmicaria melanogaster from Brunei.
Journal of natural products 2007;70(2):160-8.
2007: Soushi Kobayashi; Hideo Nemoto; Hideki Sakai; Toshiyasu Sasaoka; Thomas F Spande; Naoki Toyooka; Hiroshi Tsuneki; Tsutomu Wada; Dejun Zhou; H Martin Garraffo; John W Daly
Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.
Beilstein journal of organic chemistry 2007;3():30.
2007: Naoki Toyooka; Dejun Zhou; Hideo Nemoto; H Martin Garraffo; Thomas F Spande; John W Daly
Flexible synthetic routes to poison-frog alkaloids of the 5,8-disubstituted indolizidine-class I: synthesis of common lactam chiral building blocks and application to the synthesis of (-)-203A, (-)-205A, and (-)-219F.
Beilstein journal of organic chemistry 2007;3():29.
2006: Paul J Weldon; Matthew Kramer; Scott Gordon; Thomas F Spande; John W Daly
A common pumiliotoxin from poison frogs exhibits enantioselective toxicity against mosquitoes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17818-21.
2006: Ralph A Saporito; Maureen A Donnelly; H Martin Garraffo; Thomas F Spande; John W Daly
Geographic and seasonal variation in alkaloid-based chemical defenses of Dendrobates pumilio from Bocas del Toro, Panama.
Journal of chemical ecology 2006;32(4):795-814.
2005: N Rabe Andriamaharavo; Marta Andriantsiferana; Paul A Stevenson; Gavin O'mahony; Herman J C Yeh; Tetsuo Kaneko; H Martin Garraffo; Thomas F Spande; John W Daly
A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar.
Journal of natural products 2005;68(12):1743-8.
2005: Cyrus Macfoy; Douglas Danosus; Raj Sandit; Tappey H Jones; H Martin Garraffo; Thomas F Spande; John W Daly
Alkaloids of anuran skin: antimicrobial function?
Zeitschrift für Naturforschung. C, Journal of biosciences 2005;60(11-12):932-7.
2005: John W Daly; Thomas F Spande; H Martin Garraffo
Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.
Journal of natural products 2005;68(10):1556-75.
2004: John W Daly; Naratitt Noimai; Boonsong Kongkathip; Ngampong Kongkathip; Jason Wilham; H Martin Garraffo; Tetsuo Kaneko; Thomas F Spande; Yuth Nimit; Jarujin Nabhitabhata; Tanya Chan-Ard
Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand.
Toxicon : official journal of the International Society on Toxinology 2004;44(8):805-15.
2004: John Philip Dumbacher; Avit Wako; Scott R Derrickson; Allan Samuelson; Thomas F Spande; John W Daly
Melyrid beetles (Choresine): a putative source for the batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):15857-60.
2004: Tappey H Jones; D A Clark; A A Edwards; Diane W Davidson; Thomas F Spande; Roy R Snelling
The chemistry of exploding ants, Camponotus spp. (cylindricus complex).
Journal of chemical ecology 2004;30(8):1479-92.
2003: Arunrat Sunthitikawinsakul; Ngampong Kongkathip; Boonsong Kongkathip; Sida Phonnakhu; John W Daly; Thomas F Spande; Yuth Nimit; Chanita Napaswat; Jittra Kasisit; Chalobon Yoosook
Anti-HIV-1 limonoid: first isolation from Clausena excavata.
Phytotherapy research : PTR 2003;17(9):1101-3.
2003: Richard W Fitch; H Martin Garraffo; Thomas F Spande; Herman J C Yeh; John W Daly
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.
Journal of natural products 2003;66(10):1345-50.
2003: John W Daly; H Martin Garraffo; Thomas F Spande; Valerie C Clark; Jingyuan Ma; Herman Ziffer; John F Cover
Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):11092-7.
2003: Arunrat Sunthitikawinsakul; Ngampong Kongkathip; Boonsong Kongkathip; Sida Phonnakhu; John W Daly; Thomas F Spande; Yuth Nimit; Sasarose Rochanaruangrai
Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.
Planta medica 2003;69(2):155-7.
2003: Hongbing Huang; Thomas F Spande; James S Panek
Highly enantioenriched tetrahydropyridines from chiral organosilanes: application to the synthesis of quinolizidine alkaloid (-)-217A.
Journal of the American Chemical Society 2003;125(3):626-7.
2002: John W Daly; Tetsuo Kaneko; Jason Wilham; H Martin Garraffo; Thomas F Spande; Alex Espinosa; Maureen A Donnelly
Bioactive alkaloids of frog skin: combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):13996-4001.
2002: Naoki Toyooka; Ayako Fukutome; Hideo Nemoto; John W Daly; Thomas F Spande; H Martin Garraffo; Tetsuo Kaneko
Synthesis of alkaloid 223A and a structural revision.
Organic letters 2002;4(10):1715-7.
2002: B P Smith; M J Tyler; T Kaneko; H Martin Garraffo; Thomas F Spande; John W Daly
Evidence for biosynthesis of pseudophrynamine alkaloids by an Australian myobatrachid frog (pseudophryne) and for sequestration of dietary pumiliotoxins.
Journal of natural products 2002;65(4):439-47.
2001: H Martin Garraffo; P Jain; Thomas F Spande; John W Daly; Tappey H Jones; L J Smith; V E Zottig
Structure of alkaloid 275A, a novel 1-azabicyclo[5.3.0]decane from a dendrobatid frog, Dendrobates lehmanni: synthesis of the tetrahydrodiastereomers.
Journal of natural products 2001;64(4):421-7.
2001: H Martin Garraffo; Thomas F Spande; P Jain; T Kaneko; Tappey H Jones; M S Blum; T M Ali; Roy R Snelling; L A Isbell; H G Robertson; John W Daly
Ammonia chemical ionization tandem mass spectrometry in structural determination of alkaloids. II. Tetraponerines from pseudomyrmecine ants.
Rapid communications in mass spectrometry : RCM 2001;15(16):1409-15.
2000: P Michel; A Rassat; John W Daly; Thomas F Spande
A stereospecific synthesis of (+/-)-5,8-disubstituted indolizidines and (+/-)-1,4-disubstituted quinolizidines found in poison frog skins.
The Journal of organic chemistry 2000;65(26):8908-18.
2000: John Philip Dumbacher; Thomas F Spande; John W Daly
Batrachotoxin alkaloids from passerine birds: a second toxic bird genus (Ifrita kowaldi) from New Guinea.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):12970-5.
2000: Chihiro Kibayashi; Sakae Aoyagi; T C Wang; K Saito; John W Daly; Thomas F Spande
Determination of absolute stereochemistry and an alternative synthesis of homopumiliotoxin 223G: identification on chiral GC columns with the natural alkaloid.
Journal of natural products 2000;63(8):1157-9.
2000: Santosh B Noronha; Herman J C Yeh; Thomas F Spande; Joseph Shiloach
Investigation of the TCA cycle and the glyoxylate shunt in Escherichia coli BL21 and JM109 using (13)C-NMR/MS.
Biotechnology and bioengineering 2000;68(3):316-27.
2000: John W Daly; H Martin Garraffo; Thomas F Spande; M W Decker; J P Sullivan; M Williams
Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics.
Natural product reports 2000;17(2):131-5.
1999: Tappey H Jones; R C Flournoy; J A Torres; Roy R Snelling; Thomas F Spande; H Martin Garraffo
3-methyl-4-phenylpyrrole from the ants Anochetus kempfi and Anochetus mayri.
Journal of natural products 1999;62(9):1343-5.
1999: H Martin Garraffo; Thomas F Spande; Tappey H Jones; John W Daly
Ammonia chemical ionization tandem mass spectrometry in structure determination of alkaloids. I. Pyrrolidines, piperidines, decahydroquinolines, pyrrolizidines, indolizidines, quinolizidines and an azabicyclo[5.3.0]decane.
Rapid communications in mass spectrometry : RCM 1999;13(15):1553-63.
1997: H Martin Garraffo; P Jain; Thomas F Spande; John W Daly
Alkaloid 223A: the first trisubstituted indolizidine from dendrobatid frogs.
Journal of natural products 1997;60(1):2-5.
1996: P Jain; H Martin Garraffo; H J Yeh; Thomas F Spande; John W Daly; N R Andriamaharavo; M Andriantsiferana
A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog (Mantella).
Journal of natural products 1996;59(12):1174-8.
1996: A Rabemanantsoa; Y Ranarivelo; M Andriantsiferana; François Tillequin; J V Silverton; H Martin Garraffo; Thomas F Spande; H J Yeh; John W Daly
A new secotrinervitane diterpene isolated from soldiers of the Madagascan termite species, Nasutitermes canaliculatus.
Journal of natural products 1996;59(9):883-6.
1996: Tappey H Jones; J A Torres; R R Snelling; Thomas F Spande
Primary tetradecenyl amines from the ant Monomorium floricola.
Journal of natural products 1996;59(8):801-2.
1995: P Jain; H Martin Garraffo; Thomas F Spande; H J Yeh; John W Daly
A new subclass of alkaloids from a dendrobatid poison frog: a structure for deoxypumiliotoxin 251H.
Journal of natural products 1995;58(1):100-4.
1994: John W Daly; S I Secunda; H Martin Garraffo; Thomas F Spande; A Wisnieski; J F Cover
An uptake system for dietary alkaloids in poison frogs (Dendrobatidae).
Toxicon : official journal of the International Society on Toxinology 1994;32(6):657-63.
1993: H Martin Garraffo; J Caceres; John W Daly; Thomas F Spande; N R Andriamaharavo; M Andriantsiferana
Alkaloids in Madagascan frogs (Mantella): pumiliotoxins, indolizidines, quinolizidines, and pyrrolizidines.
Journal of natural products 1993;56(7):1016-38.
1993: H Martin Garraffo; Thomas F Spande; John W Daly; A Baldessari; Eduardo G Gros
Alkaloids from bufonid toads (Melanophryniscus): decahydroquinolines, pumiliotoxins and homopumiliotoxins, indolizidines, pyrrolizidines, and quinolizidines.
Journal of natural products 1993;56(3):357-73.
1992: John Philip Dumbacher; B M Beehler; Thomas F Spande; H Martin Garraffo; John W Daly
Homobatrachotoxin in the genus Pitohui: chemical defense in birds?
Science (New York, N.Y.) 1992;258(5083):799-801.
1992: John W Daly; S I Secunda; H Martin Garraffo; Thomas F Spande; A Wisnieski; C Nishihira; J F Cover
Variability in alkaloid profiles in neotropical poison frogs (Dendrobatidae): genetic versus environmental determinants.
Toxicon : official journal of the International Society on Toxinology 1992;30(8):887-98.
1992: Thomas F Spande; H Martin Garraffo; H J Yeh; Q L Pu; Lewis K Pannell; John W Daly
A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F.
Journal of natural products 1992;55(6):707-22.
1990: John W Daly; H Martin Garraffo; Lewis K Pannell; Thomas F Spande; Cinzia Severini; Vittorio Erspamer
Alkaloids from Australian frogs (Myobatrachidae): pseudophrynamines and pumiliotoxins.
Journal of natural products 1990;53(2):407-21.