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Taylor Spangler

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David J O'Neill; Taylor B Spangler; Nicole R Sullivan; Eugene A Terefenko; Eugene Trybulski; Albert J Uveges; An Vu; Garth T Whiteside; Adedayo Adedoyin; Jenifer A Bray; Darlene C Deecher; Andrew Fensome; Joel A Goldberg; Jim Harrison; Liza Leventhal; Charles Mann; Lilly Mark; Lisa M Nogle; Puwen Zhang
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
Nicole R Sullivan; Liza Leventhal; James Harrison; Valerie A Smith; Terri A Cummons; Taylor B Spangler; Shaiu-Ching Sun; Peimin Lu; Albert J Uveges; Brian W Strassle; Michael J Piesla; Rana Ramdass; Alena Barry; Jonathan Schantz; William Adams; Garth T Whiteside; Adedayo Adedoyin; Philip G Jones
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
Richard E Mewshaw; Dahui Zhou; Ping Zhou; Xiaojie Shi; Geoffrey Hornby; Taylor B Spangler; Rosemary Scerni; Deborah Smith; Lee E Schechter; Terrance H Andree
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.

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All Publications

2011: David J O'Neill; Taylor B Spangler; Nicole R Sullivan; Eugene A Terefenko; Eugene Trybulski; Albert J Uveges; An Vu; Garth T Whiteside; Adedayo Adedoyin; Jenifer A Bray; Darlene C Deecher; Andrew Fensome; Joel A Goldberg; Jim Harrison; Liza Leventhal; Charles Mann; Lilly Mark; Lisa M Nogle; Puwen Zhang
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
Journal of medicinal chemistry 2011;54(19):6824-31.
2007: Nicole R Sullivan; Liza Leventhal; James Harrison; Valerie A Smith; Terri A Cummons; Taylor B Spangler; Shaiu-Ching Sun; Peimin Lu; Albert J Uveges; Brian W Strassle; Michael J Piesla; Rana Ramdass; Alena Barry; Jonathan Schantz; William Adams; Garth T Whiteside; Adedayo Adedoyin; Philip G Jones
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1294-304.
2004: Richard E Mewshaw; Dahui Zhou; Ping Zhou; Xiaojie Shi; Geoffrey Hornby; Taylor B Spangler; Rosemary Scerni; Deborah Smith; Lee E Schechter; Terrance H Andree
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
Journal of medicinal chemistry 2004;47(15):3823-42.
2003: Jean Y Zhang; Stanley P Nawoschik; Dianne Kowal; Deborah Smith; Taylor B Spangler; Rafal Ochalski; Lee E Schechter; John Dunlop
Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.
European journal of pharmacology 2003;472(1-2):33-8.
2002: Albert J Uveges; Dianne Kowal; Yingxin Zhang; Taylor B Spangler; John Dunlop; Simon Semus; Philip G Jones
The role of transmembrane helix 5 in agonist binding to the human H3 receptor.
The Journal of pharmacology and experimental therapeutics 2002;301(2):451-8.
2001: K L Meagher; Richard E Mewshaw; Deborah A Evrard; Ping Zhou; Deborah L Smith; Rosemary Scerni; Taylor B Spangler; S Abulhawa; Xiaojie Shi; Lee E Schechter; Terrance H Andree
Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(14):1885-8.
1997: Richard E Mewshaw; J Kavanagh; Gary Stack; Karen L Marquis; Xiaojie Shi; M Z Kagan; MB Webb; A H Katz; A Park; Y H Kang; Magid A Abou-Gharbia; Rosemary Scerni; T Wasik; L Cortes-Burgos; Taylor B Spangler; Julie A Brennan; Michael J Piesla; Hossein Mazandarani; Mark Cockett; Rafal Ochalski; Joseph Coupet; Terrance H Andree
New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.
Journal of medicinal chemistry 1997;40(26):4235-56.