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Brian Spar

Research Profile

Chemicals & Drugs

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Obesity

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Publications

TOP 3
Jing Su; Haiqun Tang; Brian A McKittrick; Huizhong Gu; Tao Guo; Gang Qian; Duane A Burnett; John W Clader; William J Greenlee; Brian E Hawes; Kim O'Neill; Brian D Spar; Blair Weig; Timothy J Kowalski; Steve Sorota
Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.
Jing Su; Brian A McKittrick; Haiqun Tang; Duane A Burnett; John W Clader; William J Greenlee; Brian E Hawes; Kim O'Neill; Brian D Spar; Blair Weig; Timothy J Kowalski; Steve Sorota; Cheng Li; Tongtong Liu
SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG.
Thavalakulamgara K Sasikumar; Li Qiang; Duane A Burnett; William J Greenlee; Brian E Hawes; Timothy J Kowalski; Kim O'Neill; Brian D Spar; Blair Weig
Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

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All Publications

2007: Jing Su; Haiqun Tang; Brian A McKittrick; Huizhong Gu; Tao Guo; Gang Qian; Duane A Burnett; John W Clader; William J Greenlee; Brian E Hawes; Kim O'Neill; Brian D Spar; Blair Weig; Timothy J Kowalski; Steve Sorota
Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(17):4845-50.
2007: Jing Su; Brian A McKittrick; Haiqun Tang; Duane A Burnett; John W Clader; William J Greenlee; Brian E Hawes; Kim O'Neill; Brian D Spar; Blair Weig; Timothy J Kowalski; Steve Sorota; Cheng Li; Tongtong Liu
SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG.
Bioorganic & medicinal chemistry 2007;15(16):5369-85.
2006: Thavalakulamgara K Sasikumar; Li Qiang; Duane A Burnett; William J Greenlee; Brian E Hawes; Timothy J Kowalski; Kim O'Neill; Brian D Spar; Blair Weig
Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.
Bioorganic & medicinal chemistry letters 2006;16(20):5427-31.
2006: Wen-Lian Wu; Duane A Burnett; Mary Ann Caplen; Martin S Domalski; Chad Bennett; William J Greenlee; Brian E Hawes; Kim O'Neill; Blair Weig; Daniel J Weston; Brian D Spar; Timothy J Kowalski
Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
Bioorganic & medicinal chemistry letters 2006;16(14):3674-8.
2006: Ruo Xu; Shengjian Li; Jaroslava Paruchova; Mark D McBriar; Henry Guzik; Anandan Palani; John W Clader; Kathleen Cox; William J Greenlee; Brian E Hawes; Timothy J Kowalski; Kim O'Neill; Brian D Spar; Blair Weig; Daniel J Weston
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(10):3285-99.
2006: Mark D McBriar; Henry Guzik; Sherry Shapiro; Jaroslava Paruchova; Ruo Xu; Anandan Palani; John W Clader; Kathleen Cox; William J Greenlee; Brian E Hawes; Timothy J Kowalski; Kim O'Neill; Brian D Spar; Blair Weig; Daniel J Weston; Constance Farley; John Cook
Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
Journal of medicinal chemistry 2006;49(7):2294-310.
2006: Timothy J Kowalski; Brian D Spar; Blair Weig; Constance Farley; John Cook; Lorraine Ghibaudi; Steve Fried; Kim O'Neill; Robert A Del Vecchio; Mark D McBriar; Henry Guzik; John W Clader; Brian E Hawes; Joyce J Hwa
Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.
European journal of pharmacology 2006;535(1-3):182-91.
2005: Anandan Palani; Sherry Shapiro; Mark D McBriar; John W Clader; William J Greenlee; Brian D Spar; Timothy J Kowalski; Constance Farley; John Cook; Margaret van Heek; Blair Weig; Kim O'Neill; Michael P Graziano; Brian E Hawes
Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.
Journal of medicinal chemistry 2005;48(15):4746-9.
2005: Mark D McBriar; Henry Guzik; Ruo Xu; Jaroslava Paruchova; Shengjian Li; Anandan Palani; John W Clader; William J Greenlee; Brian E Hawes; Timothy J Kowalski; Kim O'Neill; Brian D Spar; Blair Weig
Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.
Journal of medicinal chemistry 2005;48(7):2274-7.
2005: Timothy J Kowalski; Brian D Spar; Lisa Markowitz; Maureen Maguire; Andrei Golovko; Shijun Yang; Constance Farley; John A Cook; Glen Tetzloff; Lizbeth M Hoos; Robert A Del Vecchio; Tatiana M Kazdoba; Martha F McCool; Joyce J Hwa; Lynn A Hyde; H Davis; Galya Vassileva; Joseph A Hedrick; Eric L Gustafson
Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice.
The Journal of endocrinology 2005;185(1):151-64.
2004: Timothy J Kowalski; Constance Farley; Mary E Cohen-Williams; Geoffrey Varty; Brian D Spar
Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.
European journal of pharmacology 2004;497(1):41-7.
2003: Constance Farley; John A Cook; Brian D Spar; Theodore M Austin; Timothy J Kowalski
Meal pattern analysis of diet-induced obesity in susceptible and resistant rats.
Obesity research 2003;11(7):845-51.