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Rolf Sparidans

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Rolf W Sparidans; Selvi Durmus; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.
Selvi Durmus; Rolf W Sparidans; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
Rolf W Sparidans; Seng Chuan Tang; Luan N Nguyen; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma.

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2013: Rolf W Sparidans; Selvi Durmus; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;925():124-8.
2012: Selvi Durmus; Rolf W Sparidans; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
Molecular pharmaceutics 2012;9(11):3236-45.
2012: Rolf W Sparidans; Seng Chuan Tang; Luan N Nguyen; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;905():150-4.
2012: Rolf W Sparidans; Marieke E B Welzen; Tahani T A Ahmed; Eline W Muilwijk; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;905():137-40.
2012: Dilek Iusuf; Kathryn E Kenworthy; Jos H Beijnen; Mike Hobbs; Rolf W Sparidans; Evita van de Steeg; Anita van Esch; Els Wagenaar; Alfred H Schinkel
Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.
Molecular pharmaceutics 2012;9(9):2497-504.
2012: Andrew K L Goey; Irma Meijerman; Hilde Rosing; Jan H M Schellens; Rolf W Sparidans; Jos H Beijnen
The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;902():151-6.
2012: Maarten J Deenen; Heinz-Josef Klümpen; Dick J Richel; Jan H M Schellens; Rolf W Sparidans; Mariette J Weterman; Jos H Beijnen; Johanna W Wilmink
Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies.
Investigational new drugs 2012;30(4):1557-65.
2012: Rolf W Sparidans; Ning Xu; Selvi Durmus; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;895-896():169-73.
2012: Rolf W Sparidans; Ning Xu; Selvi Durmus; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;895-896():174-7.
2012: Rolf W Sparidans; Selvi Durmus; Jan H M Schellens; Alfred H Schinkel; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;889-890():144-7.
2012: Sara G A van Velsen; Marlise P De Roos; Inge M Haeck; Rolf W Sparidans; Carla A F M Bruijnzeel-Koomen
The potency of clobetasol propionate: serum levels of clobetasol propionate and adrenal function during therapy with 0.05% clobetasol propionate in patients with severe atopic dermatitis.
The Journal of dermatological treatment 2012;23(1):16-20.
2012: M E M Dolman; Stefan Harmsen; Wim E Hennink; György Kéri; Marie Lacombe; László Őrfi; Ebel H E Pieters; Rolf W Sparidans; Gert Storm; Bálint Szokol; Robbert J Kok
Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells.
International journal of nanomedicine 2012;7():417-33.
2011: Rolf W Sparidans; Liselot B J Valkenburg-van Iersel; Jan den Hartigh; Irene Martens; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(21):1851-6.
2011: Birk Poller; Dilek Iusuf; Rolf W Sparidans; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
Differential impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on axitinib brain accumulation and oral plasma pharmacokinetics.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(5):729-35.
2011: Andrew K L Goey; Rolf W Sparidans; Irma Meijerman; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(1):41-8.
2010: Irene van den Broek; Rolf W Sparidans; Annemieke W J van Winden; Marie-Christine W Gast; Eric J van Dulken; Jan H M Schellens; Jos H Beijnen
The absolute quantification of eight inter-α-trypsin inhibitor heavy chain 4 (ITIH4)-derived peptides in serum from breast cancer patients.
Proteomics. Clinical applications 2010;4(12):931-9.
2010: Rolf W Sparidans; Dilek Iusuf; Alfred H Schinkel; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(28):2751-9.
2010: Annemieke W J van Winden; Irene van den Broek; Marie-Christine W Gast; Judith Y M N Engwegen; Rolf W Sparidans; Eric J van Dulken; Annekatrien C T M Depla; Annemieke Cats; Jan H M Schellens; Petra H M Peeters; Jos H Beijnen; Carla H van Gils
Serum degradome markers for the detection of breast cancer.
Journal of proteome research 2010;9(8):3781-8.
2010: Rolf W Sparidans; Pim N J Langendijk; Eric Boers; Erik van Kan; Hanno L Tan; Jos H Beijnen
Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(23):2168-72.
2010: Rolf W Sparidans; Sara G A van Velsen; Marlise P de Roos; Jan H M Schellens; Carla A F M Bruijnzeel-Koomen; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(23):2150-4.
2010: Irene van den Broek; Rolf W Sparidans; Jan H M Schellens; Jos H Beijnen
Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples.
Rapid communications in mass spectrometry : RCM 2010;24(13):1842-50.
2010: Jurjen S Lagas; Rolf W Sparidans; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.
Molecular pharmacology 2010;77(4):687-94.
2010: Irene van den Broek; Rolf W Sparidans; Jan H M Schellens; Jos H Beijnen
Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(5-6):590-602.
2010: Jurjen S Lagas; Robert A B van Waterschoot; Rolf W Sparidans; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.
Molecular cancer therapeutics 2010;9(2):319-26.
2009: Rolf W Sparidans; Dilek Iusuf; Alfred H Schinkel; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(32):4090-6.
2009: Robert A B van Waterschoot; Rogier W Rooswinkel; Rolf W Sparidans; Antonius E van Herwaarden; Jos H Beijnen; Alfred H Schinkel
Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(12):2305-13.
2009: Rolf W Sparidans; Maria L H Vlaming; Jurjen S Lagas; Alfred H Schinkel; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(3):269-76.
2008: Irene van den Broek; Rolf W Sparidans; Jan H M Schellens; Jos H Beijnen
Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum.
Rapid communications in mass spectrometry : RCM 2008;22(18):2915-28.
2008: Irene van den Broek; Rolf W Sparidans; Jan H M Schellens; Jos H Beijnen
Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;872(1-2):1-22.
2008: Rolf W Sparidans; Jurjen S Lagas; Alfred H Schinkel; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;872(1-2):77-82.
2008: Jurjen S Lagas; Rolf W Sparidans; Robert A B van Waterschoot; Els Wagenaar; Jos H Beijnen; Alfred H Schinkel
P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.
Antimicrobial agents and chemotherapy 2008;52(3):1034-9.
2008: Robert A B van Waterschoot; Antonius E van Herwaarden; Jurjen S Lagas; Rolf W Sparidans; Els Wagenaar; Cornelia M M van der Kruijssen; Joyce A Goldstein; Darryl C Zeldin; Jos H Beijnen; Alfred H Schinkel
Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.
Molecular pharmacology 2008;73(3):1029-36.
2008: Milly E Attema-de Jonge; Judith M Bekkers; Heleen Oudemans-van Straaten; Rolf W Sparidans; Eric J F Franssen
Simple and sensitive method for quantification of low tobramycin concentrations in human plasma using HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;862(1-2):257-62.
2007: L B J van Iersel; Matty Verlaan; Alexander L Vahrmeijer; EL van Persijn van Meerten; F G J Tijl; Rolf W Sparidans; Hans Gelderblom; Peter Kuppen; R A E M Tollenaar; Cornelis J H van de Velde
Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: a clinical and pharmacologic evaluation.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2007;33(7):874-81.
2007: Rolf W Sparidans; Jurjen S Lagas; Afred H Schinkel; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;855(2):200-10.
2007: Irene van den Broek; Rolf W Sparidans; Jan H M Schellens; Jos H Beijnen
Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;854(1-2):245-59.
2007: Rolf W Sparidans; Jan M Prins; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma.
Biomedical chromatography : BMC 2007;21(6):621-7.
2007: Esther F A Brandon; Rolf W Sparidans; Ronald D van Ooijen; Irma Meijerman; Luis Lopez Lazaro; Ignasio Manzanares; Jos H Beijnen; Jan H M Schellens
In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug.
Investigational new drugs 2007;25(1):9-19.
2006: Rolf W Sparidans; Frits Dost; Kristel M L Crommentuyn; Alwin D R Huitema; Jan H M Schellens; Jos H Beijnen
Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma.
Biomedical chromatography : BMC 2006;20(8):671-3.
2006: Rolf W Sparidans; Tessa M Bosch; M Jörger; Jan H M Schellens; Jos H Beijnen
Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;839(1-2):45-53.
2006: I van den Broek; Rolf W Sparidans; Alwin D R Huitema; J H M Schellens; Jos H Beijnen
Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;837(1-2):49-58.
2006: Esther F A Brandon; Rolf W Sparidans; Kees-Jan Guijt; Sjoerd Löwenthal; Irma Meijerman; Jos H Beijnen; Jan H M Schellens
In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug.
Investigational new drugs 2006;24(1):3-14.
2006: Rolf W Sparidans; Frits Dost; Kristel M L Crommentuyn; Alwin D R Huitema; Jan H M Schellens; Jos H Beijnen
Liquid chromatographic assay for the protease inhibitor atazanavir in plasma.
Biomedical chromatography : BMC 2006;20(1):72-6.
2005: Wandena S Siegel-Lakhai; Mirjam Crul; Steven Zhang; Rolf W Sparidans; Dick Pluim; A Howes; B Solanki; Jos H Beijnen; J H M Schellens
Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours.
British journal of cancer 2005;93(11):1222-9.
2005: Jeany M Rademaker-Lakhai; Mirjam Crul; Dick Pluim; Rolf W Sparidans; Paul Baas; Jos H Beijnen; nico van zandwijk; Jan H M Schellens
Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
Anti-cancer drugs 2005;16(9):1029-36.
2005: Esther F A Brandon; Irma Meijerman; Joyce S Klijn; Dineke den Arend; Rolf W Sparidans; Louis López Lázaro; Jos H Beijnen; Jan H M Schellens
In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction.
Anti-cancer drugs 2005;16(9):935-43.
2005: Antonius E van Herwaarden; Johan W Smit; Rolf W Sparidans; Els Wagenaar; Cornelia M M van der Kruijssen; Jan H M Schellens; Jos H Beijnen; Alfred H Schinkel
Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):892-5.
2005: Esther F A Brandon; Ronald D van Ooijen; Rolf W Sparidans; Luis López Lázaro; albert heck; Jos H Beijnen; Jan H M Schellens
Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry.
Journal of mass spectrometry : JMS 2005;40(6):821-31.
2005: Anthe S Zandvliet; Alwin D R Huitema; Milly E De Jonge; Rob den Hoed; Rolf W Sparidans; Vincent M Hendriks; Wim Van den Brink; Jan M Van Ree; Jos H Beijnen
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.
Basic & clinical pharmacology & toxicology 2005;96(1):71-9.
2004: Esther F A Brandon; Rolf W Sparidans; Irma Meijerman; Ignasio Manzanares; Jos H Beijnen; Jan H M Schellens
In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug.
Investigational new drugs 2004;22(3):241-51.
2004: Kristel M L Crommentuyn; Jan W Mulder; Rolf W Sparidans; Alwin D R Huitema; Jan H M Schellens; Jos H Beijnen
Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;38(8):e73-5.
2004: H J G Desirée van den Bongard; Rolf W Sparidans; David J P Critchley; Jos H Beijnen; Jan H M Schellens
Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol.
Investigational new drugs 2004;22(2):151-8.
2004: Sanjay U C Sankatsing; Patrick G Hoggard; Alwin D R Huitema; Rolf W Sparidans; Stephen Kewn; Kristel M L Crommentuyn; Joep M A Lange; Jos H Beijnen; David J Back; Jan M Prins
Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools.
Clinical pharmacokinetics 2004;43(12):823-32.
2004: Rolf W Sparidans; Jan H M Schellens; Luis López-Lázaro; José Jimeno; Jos H Beijnen
Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.
Biomedical chromatography : BMC 2004;18(1):16-20.
2004: Serge van Ruth; Ron A A Mathôt; Rolf W Sparidans; Jos H Beijnen; Vic J Verwaal; Frans A N Zoetmulder
Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy.
Clinical pharmacokinetics 2004;43(2):131-43.
2003: Rolf W Sparidans; Linda Silvertand; Frits Dost; Joost Rothbarth; Gerard J Mulder; Jan H M Schellens; Jos H Beijnen
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
Biomedical chromatography : BMC 2003;17(7):458-64.
2003: Mirjam Crul; Nadja E Schoemaker; Dick Pluim; Marc Maliepaard; René W M Underberg; Margaret Schot; Rolf W Sparidans; Paul Baas; Jos H Beijnen; nico van zandwijk; Jan H M Schellens
Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3526-33.
2003: Rolf W Sparidans; Kristel M L Crommentuyn; Jan H M Schellens; Jos H Beijnen
Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;791(1-2):227-33.
2003: Joost Rothbarth; Ruud A Woutersen; Rolf W Sparidans; Cornelis J H van de Velde; Gerard J Mulder
Melphalan antitumor efficacy and hepatotoxicity: the effect of variable infusion duration in the hepatic artery.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1098-103.
2003: Cornelis H W Koks; Alwin D R Huitema; Eugene D M B Kroon; Theshinee Chuenyam; Rolf W Sparidans; Joep M A Lange; Jos H Beijnen
Population pharmacokinetics of itraconazole in Thai HIV-1-infected persons.
Therapeutic drug monitoring 2003;25(2):229-33.
2002: Rolf W Sparidans; Mirjam Crul; Jan H M Schellens; Jos H Beijnen
Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;780(2):423-30.
2002: Joost Rothbarth; Rolf W Sparidans; Jos H Beijnen; Leo J Schultze Kool; Hein Putter; Cornelis J H van de Velde; Gerard J Mulder
Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake.
The Journal of pharmacology and experimental therapeutics 2002;303(2):736-40.
2002: Cornelis H W Koks; Rolf W Sparidans; Georgette Lucassen; Kristel M L Crommentuyn; Jos H Beijnen
Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;767(1):103-10.
2002: Serge C L M Cremers; Rolf W Sparidans; Hartigh Jan den; Neveen Agnes Therese Hamdy; Pieter Vermeij; Socrates E Papapoulos
A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis.
European journal of clinical pharmacology 2002;57(12):883-90.
2001: Rolf W Sparidans; Hilde Rosing; Michel J X Hillebrand; Luis López-Lázaro; José Jimeno; Ignasio Manzanares; Charlotte van Kesteren; Esteban Cvitkovic; A T van Oosterom; J H M Schellens; Jos H Beijnen
Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.
Anti-cancer drugs 2001;12(8):653-66.
2001: Rolf W Sparidans; Ellen Stokvis; José Jimeno; Luis López-Lázaro; J H M Schellens; Jos H Beijnen
Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F.
Anti-cancer drugs 2001;12(7):575-82.
2001: Joop C M Waterval; J C Bloks; Rolf W Sparidans; Jos H Beijnen; Ignacio Rodríguez-Campos; Auke Bult; Henk Lingeman; Willy J M Underberg
Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(1):161-8.
2001: Rolf W Sparidans; Richard Hoetelmans; Jos H Beijnen
Liquid chromatographic assay for simultaneous determination of abacavir and mycophenolic acid in human plasma using dual spectrophotometric detection.
Journal of chromatography. B, Biomedical sciences and applications 2001;750(1):155-61.
2000: Raymond Evers; Marcel de Haas; Rolf W Sparidans; Jos H Beijnen; peter wielinga; Jan Lankelma; Piet Borst
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export.
British journal of cancer 2000;83(3):375-83.
2000: Rolf W Sparidans; Richard Hoetelmans; Jos H Beijnen
Sensitive liquid chromatographic assay for amprenavir, a human immunodeficiency virus protease inhibitor, in human plasma, cerebrospinal fluid and semen.
Journal of chromatography. B, Biomedical sciences and applications 2000;742(1):185-92.
2000: Rolf W Sparidans; J den Hartig; Serge C L M Cremers; Jos H Beijnen; Pieter Vermeij
Semi-automatic liquid chromatographic analysis of olpadronate in urine and serum using derivatization with (9-fluorenylmethyl)chloroformate.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(2):331-41.
1999: Agnes I Veldkamp; Rolf W Sparidans; Richard Hoetelmans; Jos H Beijnen
Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;736(1-2):123-8.
1999: Rolf W Sparidans; Agnes I Veldkamp; Richard Hoetelmans; Jos H Beijnen
Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde.
Journal of chromatography. B, Biomedical sciences and applications 1999;736(1-2):115-21.
1999: Rolf W Sparidans; Babs G Taal; Jos H Beijnen
Bioanalysis of m-iodobenzylguanidine in plasma by high-performance liquid chromatography after derivatization with benzoin.
Journal of chromatography. B, Biomedical sciences and applications 1999;730(2):193-9.
1999: Rolf W Sparidans; Jan den Hartigh; Serge C L M Cremers; Jos H Beijnen; Pieter Vermeij
Semi-automatic liquid chromatographic analysis of pamidronate in urine after derivatization with 1-naphthylisothiocyanate.
Journal of chromatography. B, Biomedical sciences and applications 1999;730(1):95-9.
1999: Rolf W Sparidans; J Jantina Kettenes-van den Bosch; Olaf van Tellingen; B Nuyen; RE Henrar; José Jimeno; Glynn Faircloth; Pablo Floriano; K L Rinehart; Jos H Beijnen
Bioanalysis of aplidine, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography after derivatization with trans-4-hydrazino-2-stilbazole.
Journal of chromatography. B, Biomedical sciences and applications 1999;729(1-2):43-53.
1999: Rolf W Sparidans; RE Henrar; José Jimeno; Glynn Faircloth; Pablo Floriano; Jos H Beijnen
Bioanalysis of thiocoraline, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography and fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;726(1-2):255-60.
1999: Rolf W Sparidans; Jan den Hartigh
Chromatographic analysis of bisphosphonates.
Pharmacy world & science : PWS 1999;21(1):1-10.
1998: Rolf W Sparidans; Irene M Twiss; S Talbot
Bisphosphonates in bone diseases.
Pharmacy world & science : PWS 1998;20(5):206-13.
1998: Rolf W Sparidans; Jan den Hartigh; Jos H Beijnen; Pieter Vermeij
Semi-automatic liquid chromatographic analysis of pamidronate in serum and citrate plasma after derivatization with 1-naphthylisothiocyanate.
Journal of chromatography. B, Biomedical sciences and applications 1998;705(2):331-9.
1997: Rolf W Sparidans; Jan den Hartigh; W M Ramp-Koopmanschap; R H Langebroek; Pieter Vermeij
The determination of pamidronate in pharmaceutical preparations by ion-pair liquid chromatography after derivatization with phenylisothiocyanate.
Journal of pharmaceutical and biomedical analysis 1997;16(3):491-7.
1997: Rolf W Sparidans; Jan den Hartigh; Jos H Beijnen; Pieter Vermeij
Determination of pamidronate in urine by ion-pair liquid chromatography after derivatization with 1-naphthylisothiocyanate.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(1):137-44.
1995: Rolf W Sparidans; Jan den Hartigh; Pieter Vermeij
High-performance ion-exchange chromatography with in-line complexation of bisphosphonates and their quality control in pharmaceutical preparations.
Journal of pharmaceutical and biomedical analysis 1995;13(12):1545-50.
1994: Irene M Twiss; R de Water; Jan den Hartigh; Rolf W Sparidans; W Ramp-Koopmanschap; H Brill; M Wijdeveld; P Vermeij
Cytotoxic effects of pamidronate on monolayers of human intestinal epithelial (Caco-2) cells and its epithelial transport.
Journal of pharmaceutical sciences 1994;83(5):699-703.