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Charles Sparks

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Jeffrey M Chamberlain; Colleen O'Dell; Charles E Sparks; Janet D Sparks
Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting.
James P Corsetti; Ron T Gansevoort; gerjan navis; Charles E Sparks; Stephan J L Bakker; Robin P F Dullaart
Apolipoprotein E predicts incident cardiovascular disease risk in women but not in men with concurrently high levels of high-density lipoprotein cholesterol and C-reactive protein.
Nhat-Tu Le; Charles E Sparks; James P Corsetti; Janet L Dehoff-Sparks; Keigi Fujiwara; Jun-Ichi Abe
Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation.

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All Publications

2013: Jeffrey M Chamberlain; Colleen O'Dell; Charles E Sparks; Janet D Sparks
Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting.
Biochemical and biophysical research communications 2013;430(1):66-71.
2012: James P Corsetti; Ron T Gansevoort; gerjan navis; Charles E Sparks; Stephan J L Bakker; Robin P F Dullaart
Apolipoprotein E predicts incident cardiovascular disease risk in women but not in men with concurrently high levels of high-density lipoprotein cholesterol and C-reactive protein.
Metabolism: clinical and experimental 2012;61(7):996-1002.
2012: Nhat-Tu Le; Charles E Sparks; James P Corsetti; Janet L Dehoff-Sparks; Keigi Fujiwara; Jun-Ichi Abe
Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation.
International journal of inflammation 2012;2012():678190.
2012: James P Corsetti; Stephan J L Bakker; Charles E Sparks; Robin P F Dullaart
Apolipoprotein A-II influences apolipoprotein E-linked cardiovascular disease risk in women with high levels of HDL cholesterol and C-reactive protein.
PloS one 2012;7(6):e39110.
2011: James P Corsetti; Ilan Goldenberg; Jeanette McCarthy; Arthur J Moss; Dan Ryan; Wojciech Zareba; Charles E Sparks
Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels.
Thrombosis and haemostasis 2011;106(6):1170-8.
2011: Janet D Sparks; Jeffrey M Chamberlain; Colleen O'Dell; Irani Khatun; M Mahmood Hussain; Charles E Sparks
Acute suppression of apo B secretion by insulin occurs independently of MTP.
Biochemical and biophysical research communications 2011;406(2):252-6.
2011: James P Corsetti; Ron T Gansevoort; gerjan navis; Charles E Sparks; Robin P F Dullaart
LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP.
Atherosclerosis 2011;214(2):373-6.
2010: Janet D Sparks; Joanne Cianci; Jenny Jokinen; Li Sheng Chen; Charles E Sparks
Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G980-9.
2010: James P Corsetti; Dan Ryan; David L Rainwater; Arthur J Moss; Wojciech Zareba; Charles E Sparks
Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(8):1657-64.
2010: James P Corsetti; Ron T Gansevoort; Charles E Sparks; Robin P F Dullaart
Inflammation reduces HDL protection against primary cardiac risk.
European journal of clinical investigation 2010;40(6):483-9.
2008: Janet D Sparks; Charles E Sparks
Overindulgence and metabolic syndrome: is FoxO1 a missing link?
The Journal of clinical investigation 2008;118(6):2012-5.
2008: James P Corsetti; Dan Ryan; Arthur J Moss; David L Rainwater; Wojciech Zareba; Charles E Sparks
Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):548-54.
2008: James P Corsetti; Dan Ryan; Arthur J Moss; Wojciech Zareba; Charles E Sparks
NAD(P)H oxidase polymorphism (C242T) and high HDL cholesterol associate with recurrent coronary events in postinfarction patients.
Atherosclerosis 2008;196(1):461-8.
2007: James P Corsetti; Dan Ryan; Arthur J Moss; David L Rainwater; Wojciech Zareba; Charles E Sparks
Glycoprotein Ibalpha polymorphism T145M, elevated lipoprotein-associated phospholipase A2, and hypertriglyceridemia predict risk for recurrent coronary events in diabetic postinfarction patients.
Diabetes 2007;56(5):1429-35.
2006: Doru V Chirieac; Nicholas O Davidson; Charles E Sparks; Janet D Sparks
PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(3):G382-8.
2006: James P Corsetti; David L Rainwater; Arthur J Moss; Wojciech Zareba; Charles E Sparks
High lipoprotein-associated phospholipase A2 is a risk factor for recurrent coronary events in postinfarction patients.
Clinical chemistry 2006;52(7):1331-8.
2006: James P Corsetti; Wojciech Zareba; Arthur J Moss; David L Rainwater; Charles E Sparks
Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation.
Atherosclerosis 2006;187(1):191-7.
2006: Janet D Sparks; Heidi L Collins; Doru V Chirieac; Joanne Cianci; Jenny Jokinen; Mark P Sowden; Chad A Galloway; Charles E Sparks
Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase.
The Biochemical journal 2006;395(2):363-71.
2005: James P Corsetti; Wojciech Zareba; Arthur J Moss; Charles E Sparks
Serum glucose and triglyceride determine high-risk subgroups in non-diabetic postinfarction patients.
Atherosclerosis 2005;183(2):293-300.
2005: Arthur J Moss; Daniel Ryan; David Oakes; Robert E Goldstein; Henry Greenberg; Monty M Bodenheimer; Mary W Brown; Robert B Case; Edward M Dwyer; Shirley Eberly; Charles W Francis; John A Gillespie; Ronald J Krone; Edgar Lichstein; Jean W MacCluer; Frank I Marcus; Jeanette McCarthy; Charles E Sparks; Wojciech Zareba
Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction.
The American journal of cardiology 2005;96(2):177-82.
2004: James P Corsetti; Wojciech Zareba; Arthur J Moss; Charles E Sparks
Apolipoprotein B determines risk for recurrent coronary events in postinfarction patients with metabolic syndrome.
Atherosclerosis 2004;177(2):367-73.
2004: Doru V Chirieac; Heidi L Collins; Joanne Cianci; Janet D Sparks; Charles E Sparks
Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats.
American journal of physiology. Endocrinology and metabolism 2004;287(1):E42-9.
2003: James P Corsetti; Wojciech Zareba; Arthur J Moss; Paul M Ridker; Victor J Marder; David L Rainwater; Charles E Sparks
Metabolic syndrome best defines the multivariate distribution of blood variables in postinfarction patients.
Atherosclerosis 2003;171(2):351-8.
2002: Doru V Chirieac; Joanne Cianci; Heidi L Collins; Janet D Sparks; Charles E Sparks
Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor.
Biochemical and biophysical research communications 2002;297(1):134-7.
2002: Tareq S Harb; Wojciech Zareba; Arthur J Moss; Paul M Ridker; Victor J Marder; Nader Rifai; Luc F Miller Watelet; Rohit Arora; Mary W Brown; Robert B Case; Edward M Dwyer; John A Gillespie; Robert E Goldstein; Henry Greenberg; Judith S Hochman; Ronald J Krone; Chang-seng Liang; Edgar Lichstein; William Little; Frank I Marcus; David Oakes; Charles E Sparks; Lucy VanVoorhees
Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction.
The American journal of cardiology 2002;89(2):216-21.
2001: Wojciech Zareba; G Pancio; Arthur J Moss; Vijay G Kalaria; Victor J Marder; HJ Weiss; LF Watelet; Charles E Sparks
Increased level of von Willebrand factor is significantly and independently associated with diabetes in postinfarction patients. THROMBO Investigators.
Thrombosis and haemostasis 2001;86(3):791-9.
2000: Janet D Sparks; W N Shaw; James P Corsetti; M Bolognino; J F Pesek; Charles E Sparks
Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity.
Metabolism: clinical and experimental 2000;49(11):1424-30.
2000: Doru V Chirieac; L R Chirieac; James P Corsetti; Joanne Cianci; Charles E Sparks; Janet D Sparks
Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1003-11.
2000: Stacy Fisher; Wojciech Zareba; Arthur J Moss; Victor J Marder; Charles E Sparks; Judith S Hochman; C Liang; Ronald J Krone
Effect of smoking on lipid and thrombogenic factors two months after acute myocardial infarction.
The American journal of cardiology 2000;86(8):813-8.
2000: Heidi L Collins; Charles E Sparks; Janet D Sparks
B48 is preferentially translated over B100 in cells with increased endogenous apo B mRNA.
Biochemical and biophysical research communications 2000;273(3):1156-60.
2000: Vijay G Kalaria; Wojciech Zareba; Arthur J Moss; G Pancio; Victor J Marder; James Morrissey; HJ Weiss; Charles E Sparks; Henry Greenberg; Edward M Dwyer; R Goldstein; LF Watelet
Gender-related differences in thrombogenic factors predicting recurrent cardiac events in patients after acute myocardial infarction. The THROMBO Investigators.
The American journal of cardiology 2000;85(12):1401-8.
2000: James P Corsetti; Janet D Sparks; R G Peterson; R L Smith; Charles E Sparks
Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats.
Atherosclerosis 2000;148(2):231-41.
1999: Mark P Sowden; Heidi L Collins; Harold C Smith; Timothy A Garrow; Janet D Sparks; Charles E Sparks
Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.
The Biochemical journal 1999;341 ( Pt 3)():639-45.
1999: Arthur J Moss; R E Goldstein; Victor J Marder; Charles E Sparks; David Oakes; Henry Greenberg; HJ Weiss; Wojciech Zareba; Mary W Brown; Chang-seng Liang; Edgar Lichstein; W C Little; John A Gillespie; L Van Voorhees; Ronald J Krone; Monty M Bodenheimer; Judith S Hochman; Edward M Dwyer; R Arora; F I Marcus; LF Watelet; Robert B Case
Thrombogenic factors and recurrent coronary events.
Circulation 1999;99(19):2517-22.
1998: D Van Mater; Mark P Sowden; Joanne Cianci; Janet D Sparks; Charles E Sparks; Nazzareno Ballatori; Harold C Smith
Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells.
Biochemical and biophysical research communications 1998;252(2):334-9.
1998: Janet D Sparks; Thuy L Phung; M Bolognino; Joanne Cianci; R Khurana; R G Peterson; Mark P Sowden; James P Corsetti; Charles E Sparks
Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: hyperinsulinemic versus insulinopenic hyperglycemia.
Metabolism: clinical and experimental 1998;47(11):1315-24.
1997: Thuy L Phung; A Roncone; K L Jensen; Charles E Sparks; Janet D Sparks
Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum.
The Journal of biological chemistry 1997;272(49):30693-702.
1997: Thuy L Phung; Robert A Mooney; D T Kulas; Charles E Sparks; Janet D Sparks
Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein B secretion by McA-RH7777 rat hepatoma cells.
Biochemical and biophysical research communications 1997;237(2):367-71.
1997: Janet D Sparks; Heidi L Collins; I Sabio; Mark P Sowden; Harold C Smith; Joanne Cianci; Charles E Sparks
Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells.
Biochimica et biophysica acta 1997;1347(1):51-61.
1996: Thuy L Phung; Mark P Sowden; Janet D Sparks; Charles E Sparks; Harold C Smith
Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat.
Metabolism: clinical and experimental 1996;45(9):1056-8.
1996: D Schock; S R Kuo; M F Steinburg; M Bolognino; Janet D Sparks; Charles E Sparks; Harold C Smith
An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1097-102.
1996: Janet D Sparks; Thuy L Phung; M Bolognino; Charles E Sparks
Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes.
The Biochemical journal 1996;313 ( Pt 2)():567-74.
1996: Janet D Sparks; Charles E Sparks
Chromatographic method for isolation and quantification of apolipoproteins B-100 and B-48.
Methods in enzymology 1996;263():104-20.
1994: Janet D Sparks; Charles E Sparks
Obese Zucker (fa/fa) rats are resistant to insulin's inhibitory effect on hepatic apo B secretion.
Biochemical and biophysical research communications 1994;205(1):417-22.
1994: Janet D Sparks; Charles E Sparks
Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.
Biochimica et biophysica acta 1994;1215(1-2):9-32.
1994: Janet D Sparks; J P Corsetti; Charles E Sparks
Liver regrowth and apolipoprotein B secretion by rat hepatocytes following partial hepatectomy.
Metabolism: clinical and experimental 1994;43(6):681-90.
1994: O G Björnsson; Janet D Sparks; Charles E Sparks; Geoffrey F Gibbons
Regulation of VLDL secretion in primary culture of rat hepatocytes: involvement of cAMP and cAMP-dependent protein kinases.
European journal of clinical investigation 1994;24(2):137-48.
1993: S G Harris; I Sabio; E Mayer; M F Steinberg; J W Backus; Janet D Sparks; Charles E Sparks; Harold C Smith
Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins.
The Journal of biological chemistry 1993;268(10):7382-92.
1993: J P Corsetti; Janet D Sparks; B Sikora; Charles E Sparks
Cellular heterogeneity in binding and uptake of low-density lipoprotein in primary rat hepatocytes.
Hepatology (Baltimore, Md.) 1993;17(4):645-50.
1992: Geoffrey F Gibbons; S M Bartlett; Charles E Sparks; Janet D Sparks
Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes.
The Biochemical journal 1992;287 ( Pt 3)():749-53.
1992: O G Björnsson; Janet D Sparks; Charles E Sparks; Geoffrey F Gibbons
Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures: relationships to hepatic calcium metabolism.
Journal of lipid research 1992;33(7):1017-27.
1992: J P Corsetti; B A Way; Charles E Sparks; Janet D Sparks
Immunolocalization, quantitation and cellular heterogeneity of apolipoprotein B in rat hepatocytes.
Hepatology (Baltimore, Md.) 1992;15(6):1117-24.
1992: Janet D Sparks; R Zolfaghari; Charles E Sparks; Harold C Smith; E A Fisher
Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats.
The Journal of clinical investigation 1992;89(5):1418-30.
1992: O G Björnsson; J M Duerden; S M Bartlett; Janet D Sparks; Charles E Sparks; Geoffrey F Gibbons
The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Short- and long-term effects.
The Biochemical journal 1992;281 ( Pt 2)():381-6.
1991: J P Corsetti; J A Sterry; Janet D Sparks; Charles E Sparks; M Weintraub
Effect of weight loss on serum lipoprotein(a) concentrations in an obese population.
Clinical chemistry 1991;37(7):1191-5.
1991: J P Corsetti; C H Weidner; Joanne Cianci; Charles E Sparks
The labeling of lipoproteins for studies of cellular binding with a fluorescent lipophilic dye.
Analytical biochemistry 1991;195(1):122-8.
1991: Harold C Smith; S R Kuo; J W Backus; S G Harris; Charles E Sparks; Janet D Sparks
In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1489-93.
1990: J W Backus; Matthew J Eagleton; S G Harris; Charles E Sparks; Janet D Sparks; Harold C Smith
Quantitation of endogenous liver apolipoprotein B mRNA editing.
Biochemical and biophysical research communications 1990;170(2):513-8.
1990: Janet D Sparks; Charles E Sparks
Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes.
The Journal of biological chemistry 1990;265(15):8854-62.
1990: Philip Greenland; N L Bowley; B Meiklejohn; K L Doane; Charles E Sparks
Blood cholesterol concentration: fingerstick plasma vs venous serum sampling.
Clinical chemistry 1990;36(4):628-30.
1990: Philip Greenland; N L Bowley; C A French; B Meiklejohn; S Gagliano; Charles E Sparks
Precision and accuracy of a portable blood analyzer system during cholesterol screening.
American journal of public health 1990;80(2):181-4.
1989: Tai C Kwong; Janet D Sparks; D J Pryce; Joanne Cianci; Charles E Sparks
Inhibition of apolipoprotein B net synthesis and secretion from cultured rat hepatocytes by the calcium-channel blocker diltiazem.
The Biochemical journal 1989;263(2):411-5.
1989: Janet D Sparks; Charles E Sparks; L L Miller
Insulin effects on apolipoprotein B production by normal, diabetic and treated-diabetic rat liver and cultured rat hepatocytes.
The Biochemical journal 1989;261(1):83-8.
1988: T K Jackson; A I Salhanick; Janet D Sparks; Charles E Sparks; M Bolognino; J M Amatruda
Insulin-mimetic effects of vanadate in primary cultures of rat hepatocytes.
Diabetes 1988;37(9):1234-40.
1988: Janet D Sparks; Charles E Sparks; M Bolognino; A M Roncone; T K Jackson; J M Amatruda
Effects of nonketotic streptozotocin diabetes on apolipoprotein B synthesis and secretion by primary cultures of rat hepatocytes.
The Journal of clinical investigation 1988;82(1):37-43.
1988: Janet D Sparks; Charles E Sparks; A M Roncone; J M Amatruda
Secretion of high and low molecular weight phosphorylated apolipoprotein B by hepatocytes from control and diabetic rats. Phosphorylation of APO BH and APO BL.
The Journal of biological chemistry 1988;263(11):5001-4.
1987: G A Tetrault; B A Meiklejohn; Charles E Sparks
Clinical utility of Ektachem-determined bilirubin fractions for classifying adult inpatients.
Clinical chemistry 1987;33(9):1662-4.
1986: Charles E Sparks; Janet D Sparks; M Bolognino; A Salhanick; P S Strumph; J M Amatruda
Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes.
Metabolism: clinical and experimental 1986;35(12):1128-36.
1986: Janet D Sparks; M Bolognino; P A Trax; Charles E Sparks
The production and utility of monoclonal antibodies to rat apolipoprotein B lipoproteins.
Atherosclerosis 1986;61(3):205-11.
1986: Janet D Sparks; Charles E Sparks; D Kritchevsky
Hypercholesterolemia and aortic glycosaminoglycans of rabbits fed semi-purified diets containing sucrose and lactose.
Atherosclerosis 1986;60(2):183-96.
1985: Tai C Kwong; Janet D Sparks; Charles E Sparks
Lipoprotein and protein binding of the calcium channel blocker diltiazem.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1985;178(2):313-6.
1985: Janet D Sparks; Charles E Sparks
Apolipoprotein B and lipoprotein metabolism.
Advances in lipid research 1985;21():1-46.