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Alexandre Specht

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Alexandre Specht; Jean-François Nicoud; Frédéric Bolze; Maurice Goeldner
Characterization of one- and two-photon photochemical uncaging efficiency.
Ruotian Jiang; Damien Lemoine; Adeline Martz; Alexandre Specht; Antoine Taly; Thomas Grutter
Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.
Alexandre Specht; David Warther; Sylvestre GUG; Cyril Herbivo; Jean-François Nicoud; Frédéric Bolze; Sébastien Charon; Loïc Donato; Maurice Goeldner
The donor-acceptor biphenyl platform: a versatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups.

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All Publications

2013: Alexandre Specht; Jean-François Nicoud; Frédéric Bolze; Maurice Goeldner
Characterization of one- and two-photon photochemical uncaging efficiency.
Methods in molecular biology (Clifton, N.J.) 2013;995():79-87.
2012: Ruotian Jiang; Damien Lemoine; Adeline Martz; Alexandre Specht; Antoine Taly; Thomas Grutter
Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.
Channels (Austin, Tex.) 2012;6(5):398-402.
2012: Alexandre Specht; David Warther; Sylvestre GUG; Cyril Herbivo; Jean-François Nicoud; Frédéric Bolze; Sébastien Charon; Loïc Donato; Maurice Goeldner
The donor-acceptor biphenyl platform: a versatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2012;11(3):578-86.
2012: Loïc Donato; Maurice Goeldner; Cyril Herbivo; Richard H Kramer; Jérémie Léonard; Alexandre Mourot; Jean-François Nicoud; Frédéric Bolze; Christopher M Davenport; David Warther; Alexandre Specht
Water-soluble, donor-acceptor biphenyl derivatives in the 2-(o-nitrophenyl)propyl series: highly efficient two-photon uncaging of the neurotransmitter γ-aminobutyric acid at λ = 800 nm.
Angewandte Chemie (International ed. in English) 2012;51(8):1840-3.
2011: Ruotian Jiang; Damien Lemoine; Adeline Martz; Antoine Taly; Sophie Gonin; Lia Prado de Carvalho; Alexandre Specht; Thomas Grutter
Agonist trapped in ATP-binding sites of the P2X2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(22):9066-71.
2011: Ruotian Jiang; Akiko Miyamoto; Adeline Martz; Alexandre Specht; Hitoshi Ishibashi; Marie Kueny-Stotz; Stefan Chassaing; Raymond Brouillard; Lia Prado de Carvalho; Maurice Goeldner; Junichi Nabekura; Mogens Nielsen; Thomas Grutter
Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro.
British journal of pharmacology 2011;162(6):1326-39.
2011: David Puliti; David Warther; Clelia Orange; Alexandre Specht; Maurice Goeldner
Small photoactivatable molecules for controlled fluorescence activation in living cells.
Bioorganic & medicinal chemistry 2011;19(3):1023-9.
2010: D Warther; Sylvestre GUG; Alexandre Specht; Frédéric Bolze; Jean-François Nicoud; Alexandre Mourot; Maurice Goeldner
Two-photon uncaging: New prospects in neuroscience and cellular biology.
Bioorganic & medicinal chemistry 2010;18(22):7753-8.
2010: David Warther; Frédéric Bolze; Jérémie Léonard; Sylvestre GUG; Alexandre Specht; David Puliti; Xiao-Hua Sun; Pascal Kessler; Yves Lutz; Jean-Luc Vonesch; Barbara Winsor; Jean-François Nicoud; Maurice Goeldner
Live-cell one- and two-photon uncaging of a far-red emitting acridinone fluorophore.
Journal of the American Chemical Society 2010;132(8):2585-90.
2008: Guillaume Guerlet; Antoine Taly; Lia Prado de Carvalho; Adeline Martz; Ruotian Jiang; Alexandre Specht; Nicolas Le Novère; Thomas Grutter
Comparative models of P2X2 receptor support inter-subunit ATP-binding sites.
Biochemical and biophysical research communications 2008;375(3):405-9.
2008: Clélia Orange; Alexandre Specht; David Puliti; Elias Sakr; Toshiaki Furuta; Barbara Winsor; Maurice Goeldner
Synthesis and photochemical properties of a light-activated fluorophore to label His-tagged proteins.
Chemical communications (Cambridge, England) 2008;(10):1217-9.
2007: Jacques-Philippe Colletier; Antoine Royant; Alexandre Specht; Benoît Sanson; Florian Nachon; Patrick Masson; Giuseppe Zaccai; Joel Sussman; Maurice Goeldner; Israel Silman; Dominique Bourgeois; Martin Weik
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1115-28.
2006: Alexandre Specht; Jean-Sébastien Thomann; Karine Alarcon; Weerawut Wittayanan; David Ogden; Toshiaki Furuta; Yuji Kurakawa; Maurice Goeldner
New photoremovable protecting groups for carboxylic acids with high photolytic efficiencies at near-UV irradiation. Application to the photocontrolled release of L-glutamate.
Chembiochem : a European journal of chemical biology 2006;7(11):1690-5.
2004: Alexandre Specht; Maurice Goeldner
1-(o-Nitrophenyl)-2,2,2-trifluoroethyl ether derivatives as stable and efficient photoremovable alcohol-protecting groups.
Angewandte Chemie (International ed. in English) 2004;43(15):2008-12.
2002: Alexandre Specht; Philippe Bernard; Maurice Goeldner; Ling Peng
Mutually induced formation of host-guest complexes between p-sulfonated calix[8]arene and photolabile cholinergic ligands.
Angewandte Chemie (International ed. in English) 2002;41(24):4706-8.
2001: Alexandre Specht; Thomas Ursby; Martin Weik; Ling Peng; Jan Kroon; Dominique Bourgeois; Maurice Goeldner
Cryophotolysis of ortho-nitrobenzyl derivatives of enzyme ligands for the potential kinetic crystallography of macromolecules.
Chembiochem : a European journal of chemical biology 2001;2(11):845-8.