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Nancy Speck

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Do Y Soung; Maren E Speck; Nancy A Speck; Laleh Talebian; Rosa Guzzo; Jay R Lieberman; Christina J Matheny; Hicham Drissi
Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.
Tomomasa Yokomizo; Amanda D Yzaguirre; Michael J Chen; Nancy A Speck; Tomoko Yamada-Inagawa; Elaine Dzierzak
Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos.
Michael J Chen; Maria Elena De Obaldia; Elaine Dzierzak; Yan Li; Chris S Vink; Tomoko Yamada-Inagawa; Qi Yang; Amanda D Yzaguirre; Avinash Bhandoola; Nancy A Speck
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.

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All Publications

2012: Do Y Soung; Maren E Speck; Nancy A Speck; Laleh Talebian; Rosa Guzzo; Jay R Lieberman; Christina J Matheny; Hicham Drissi
Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(7):1585-97.
2012: Tomomasa Yokomizo; Amanda D Yzaguirre; Michael J Chen; Nancy A Speck; Tomoko Yamada-Inagawa; Elaine Dzierzak
Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos.
Nature protocols 2012;7(3):421-31.
2011: Michael J Chen; Maria Elena De Obaldia; Elaine Dzierzak; Yan Li; Chris S Vink; Tomoko Yamada-Inagawa; Qi Yang; Amanda D Yzaguirre; Avinash Bhandoola; Nancy A Speck
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.
Cell stem cell 2011;9(6):541-52.
2011: Xiongwei Cai; Michael J Chen; Maria Elena De Obaldia; Patricia Ernst; Justin J Gaudet; James K Mangan; Zaw Oo; Nancy A Speck
Runx1 loss minimally impacts long-term hematopoietic stem cells.
PloS one 2011;6(12):e28430.
2010: Takeshi Corpora; Liya Roudaia; Zaw Min Oo; Wei Chen; Ekaterina Manuylova; Xiongwei Cai; Michael J Chen; Tomasz Cierpicki; Nancy A Speck; John H Bushweller
Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.
Journal of molecular biology 2010;402(3):560-77.
2010: Gemma Swiers; Nancy A Speck; Marella F T R de Bruijn
Visualizing blood cell emergence from aortic endothelium.
Cell stem cell 2010;6(4):289-90.
2009: Peter C. Hollenhorst; Katherine J Chandler; Rachel L Poulsen; W Evan Johnson; Nancy A Speck; Barbara J Graves
DNA specificity determinants associate with distinct transcription factor functions.
PLoS genetics 2009;5(12):e1000778.
2009: Sangho Park; Wei Chen; Tomasz Cierpicki; Marco Tonelli; Xiongwei Cai; Nancy A Speck; John H Bushweller
Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood 2009;113(15):3558-67.
2009: Liya Roudaia; Matthew D Cheney; Ekaterina Manuylova; Wei Chen; Michelle Morrow; Sangho Park; Chung-Tsai Lee; Prabhjot Kaur; Owen Williams; John H Bushweller; Nancy A Speck
CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Blood 2009;113(13):3070-9.
2009: Michael J Chen; Tomomasa Yokomizo; Brandon M Zeigler; Elaine Dzierzak; Nancy A Speck
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.
Nature 2009;457(7231):887-91.
2008: Yalin Guo; Ivan P Maillard; Sankhamala Chakraborti; Ellen V Rothenberg; Nancy A Speck
Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification.
Blood 2008;112(3):480-92.
2008: Liya Roudaia; Nancy A Speck
A MENage à Trois in leukemia.
Cancer cell 2008;14(1):3-5.
2008: Craig D Jude; Justin J Gaudet; Nancy A Speck; Patricia Ernst
Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.
Cell cycle (Georgetown, Tex.) 2008;7(5):586-91.
2008: Elaine Dzierzak; Nancy A Speck
Of lineage and legacy: the development of mammalian hematopoietic stem cells.
Nature immunology 2008;9(2):129-36.
2008: Gang Huang; Pu Zhang; Hideyo Hirai; Shannon Elf; Xiaomei Yan; Zhao Chen; Steffen Koschmieder; Yutaka Okuno; Tajhal Dayaram; Joseph D Growney; Ramesh A Shivdasani; D Gary Gilliland; Nancy A Speck; Stephen D Nimer; Daniel G Tenen
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Nature genetics 2008;40(1):51-60.
2007: Michael J Gorczynski; Jolanta Grembecka; Yunpeng Zhou; Yali Kong; Liya Roudaia; Mike Douvas; Miki Newman; Izabela Bielnicka; Gwen Baber; Takeshi Corpora; Jianxia Shi; Mohini Sridharan; Ryan H Lilien; Bruce Randall Donald; Nancy A Speck; Milton L Brown; John H Bushweller
Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.
Chemistry & biology 2007;14(10):1186-97.
2007: Yizhou Liu; Wei Chen; Justin Gaudet; Matthew D Cheney; Liya Roudaia; Tomasz Cierpicki; Rachel C Klet; Kari Hartman; Thomas M Laue; Nancy A Speck; John H Bushweller
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer cell 2007;11(6):483-97.
2007: Christina J Matheny; Maren E Speck; Patrick R Cushing; Yunpeng Zhou; Takeshi Corpora; Michael Regan; Miki Newman; Liya Roudaia; Caroline L Speck; Ting-Lei Gu; Stephen M Griffey; John H Bushweller; Nancy A Speck
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.
The EMBO journal 2007;26(4):1163-75.
2007: Laleh Talebian; Zhe Li; Yalin Guo; Justin Gaudet; Maren E Speck; Daisuke Sugiyama; Prabhjot Kaur; Warren S Pear; Ivan P Maillard; Nancy A Speck
T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.
Blood 2007;109(1):11-21.
2006: Zhe Li; Stephen M Lukasik; Yizhou Liu; Jolanta Grembecka; Izabela Bielnicka; John H Bushweller; Nancy A Speck
A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.
Journal of molecular biology 2006;364(5):1073-83.
2006: Brandon M Zeigler; Daisuke Sugiyama; Michael Chen; Yalin Guo; Karen M Downs; Nancy A Speck
The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential.
Development (Cambridge, England) 2006;133(21):4183-92.
2006: Yizhou Liu; Matthew D Cheney; Justin Gaudet; Maksymilian Chruszcz; Stephen M Lukasik; Daisuke Sugiyama; Jeff Lary; James Cole; Zbyszek Dauter; Wladek Minor; Nancy A Speck; John H Bushweller
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
Cancer cell 2006;9(4):249-60.
2006: Zhe Li; Michael J Chen; Terryl Stacy; Nancy A Speck
Runx1 function in hematopoiesis is required in cells that express Tek.
Blood 2006;107(1):106-10.
2005: Mondira Kundu; Sheila Compton; Lisa Garrett-Beal; Terryl Stacy; Matthew F Starost; Michael Eckhaus; Nancy A Speck; P Paul Liu
Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma.
Blood 2005;106(10):3621-4.
2005: Joseph D Growney; Hirokazu Shigematsu; Zhe Li; Benjamin H Lee; Jennifer Adelsperger; Rebecca Rowan; David P Curley; Jeffery L Kutok; Koichi Akashi; Ifor Williams; Nancy A Speck; D Gary Gilliland
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.
Blood 2005;106(2):494-504.
2004: Jiangli Yan; Yizhou Liu; Stephen M Lukasik; Nancy A Speck; John H Bushweller
CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.
Nature structural & molecular biology 2004;11(9):901-6.
2004: Marella F T R de Bruijn; Nancy A Speck
Core-binding factors in hematopoiesis and immune function.
Oncogene 2004;23(24):4238-48.
2004: Trista E North; Terryl Stacy; Christina J Matheny; Nancy A Speck; Marella F T R de Bruijn
Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.
Stem cells (Dayton, Ohio) 2004;22(2):158-68.
2003: Lina Zhang; Zhe Li; Jiangli Yan; Padmanava Pradhan; Takeshi Corpora; Matthew D Cheney; Jerónimo Bravo; Amy J Warren; John H Bushweller; Nancy A Speck
Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit.
The Journal of biological chemistry 2003;278(35):33097-104.
2003: Zhe Li; Jiangli Yan; Christina J Matheny; Takeshi Corpora; Jerónimo Bravo; Amy J Warren; John H Bushweller; Nancy A Speck
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
The Journal of biological chemistry 2003;278(35):33088-96.
2003: Lina Zhang; Stephen M Lukasik; Nancy A Speck; John H Bushweller
Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.
Blood cells, molecules & diseases 2003;30(2):147-56.
2002: Janelle Miller; Alan Horner; Terryl Stacy; Christopher Lowrey; Jane B Lian; Gary Stein; Glen H Nuckolls; Nancy A Speck
The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.
Nature genetics 2002;32(4):645-9.
2002: Stephen M Lukasik; Lina Zhang; Takeshi Corpora; Sarah Tomanicek; Yuanhong Li; Mondira Kundu; Kari Hartman; P Paul Liu; Thomas M Laue; Rodney L Biltonen; Nancy A Speck; John H Bushweller
Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.
Nature structural biology 2002;9(9):674-9.
2002: Nancy A Speck; D Gary Gilliland
Core-binding factors in haematopoiesis and leukaemia.
Nature reviews. Cancer 2002;2(7):502-13.
2002: Trista E North; Marella F T R de Bruijn; Terryl Stacy; Laleh Talebian; Evan Lind; Catherine Robin; Michael Binder; Elaine Dzierzak; Nancy A Speck
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
Immunity 2002;16(5):661-72.
2001: Nancy A Speck
Core binding factor and its role in normal hematopoietic development.
Current opinion in hematology 2001;8(4):192-6.
2001: J D Miller; Terryl Stacy; P Paul Liu; Nancy A Speck
Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells.
Blood 2001;97(8):2248-56.
2001: Jerónimo Bravo; Zhe Li; Nancy A Speck; Amy J Warren
The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp.
Nature structural biology 2001;8(4):371-8.
2000: YY Tang; J Shi; Lina Zhang; A Davis; Jerónimo Bravo; Amy J Warren; Nancy A Speck; John H Bushweller
Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.
The Journal of biological chemistry 2000;275(50):39579-88.
2000: Marella F T R de Bruijn; M C Peeters; T Luteijn; P Visser; Nancy A Speck; Elaine Dzierzak
CFU-S(11) activity does not localize solely with the aorta in the aorta-gonad-mesonephros region.
Blood 2000;96(8):2902-4.
2000: Marella F T R de Bruijn; Nancy A Speck; M C Peeters; Elaine Dzierzak
Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo.
The EMBO journal 2000;19(11):2465-74.
2000: YY Tang; BE Crute; JJ Kelley; X Huang; Jiangli Yan; J Shi; Kari Hartman; Thomas M Laue; Nancy A Speck; John H Bushweller
Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.
FEBS letters 2000;470(2):167-72.
2000: Ting-Lei Gu; TL Goetz; Barbara J Graves; Nancy A Speck
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).
Molecular and cellular biology 2000;20(1):91-103.
2000: TL Goetz; Ting-Lei Gu; Nancy A Speck; Barbara J Graves
Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.
Molecular and cellular biology 2000;20(1):81-90.
1999: MJ Berardi; C Sun; M Zehr; Frits Abildgaard; J Peng; Nancy A Speck; John H Bushweller
The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.
Structure (London, England : 1993) 1999;7(10):1247-56.
1999: W J Song; M G Sullivan; Robert D Legare; S Hutchings; X Tan; Dubravka Kufrin; J Ratajczak; I C Resende; C Haworth; R Hock; Mignon L Loh; C Felix; Denis-Claude Roy; Lambert Busque; David M Kurnit; C Willman; A M Gewirtz; Nancy A Speck; John H Bushweller; Frederick P Li; K Gardiner; Mortimer Poncz; John M Maris; D Gary Gilliland
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
Nature genetics 1999;23(2):166-75.
1999: X Huang; J W Peng; Nancy A Speck; John H Bushweller
Solution structure of core binding factor beta and map of the CBF alpha binding site.
Nature structural biology 1999;6(7):624-7.
1999: A F Lewis; Terryl Stacy; William R Green; Lekidelu Taddesse-Heath; Janet W Hartley; Nancy A Speck
Core-binding factor influences the disease specificity of Moloney murine leukemia virus.
Journal of virology 1999;73(7):5535-47.
1999: Trista E North; Ting-Lei Gu; Terryl Stacy; Qingru Wang; L Howard; Michael Binder; M Marín-Padilla; Nancy A Speck
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.
Development (Cambridge, England) 1999;126(11):2563-75.
1999: Nancy A Speck; Terryl Stacy; Qingru Wang; Trista E North; Ting-Lei Gu; J Miller; Michael Binder; M Marín-Padilla
Core-binding factor: a central player in hematopoiesis and leukemia.
Cancer research 1999;59(7 Suppl):1789s-1793s.
1998: N Adya; Terryl Stacy; Nancy A Speck; P Paul Liu
The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.
Molecular and cellular biology 1998;18(12):7432-43.
1998: X Huang; Nancy A Speck; John H Bushweller
Complete heteronuclear NMR resonance assignments and secondary structure of core binding factor beta (1-141).
Journal of biomolecular NMR 1998;12(3):459-60.
1998: X Huang; BE Crute; C Sun; YY Tang; JJ Kelley; A F Lewis; Kari Hartman; Thomas M Laue; Nancy A Speck; John H Bushweller
Overexpression, purification, and biophysical characterization of the heterodimerization domain of the core-binding factor beta subunit.
The Journal of biological chemistry 1998;273(4):2480-7.
1997: DA Yergeau; Christopher J Hetherington; Qingru Wang; P Zhang; A H Sharpe; Michael Binder; M Marín-Padilla; Daniel G Tenen; Nancy A Speck; Dong-Er Zhang
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.
Nature genetics 1997;15(3):303-6.
1996: Robert S Adelstein; Francis S Collins; A Hajra; C A Kelley; P Paul Liu; Nancy A Speck; Terryl Stacy; Qingru Wang
The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15523.
1996: A Hajra; P P Liu; Nancy A Speck; Francis S Collins
Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.
Molecular and cellular biology 1996;16(12):7185.
1996: Qingru Wang; Terryl Stacy; J D Miller; A F Lewis; Ting-Lei Gu; X Huang; John H Bushweller; J C Bories; F W Alt; G Ryan; P Paul Liu; Anthony Wynshaw-Boris; Michael Binder; M Marín-Padilla; A H Sharpe; Nancy A Speck
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
Cell 1996;87(4):697-708.
1996: Lucio H Castilla; cisca wijmenga; Qingru Wang; Terryl Stacy; Nancy A Speck; Michael Eckhaus; M Marín-Padilla; Francis S Collins; Anthony Wynshaw-Boris; P Paul Liu
Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.
Cell 1996;87(4):687-96.
1996: BE Crute; A F Lewis; Z Wu; John H Bushweller; Nancy A Speck
Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain.
The Journal of biological chemistry 1996;271(42):26251-60.
1996: Qingru Wang; Terryl Stacy; Michael Binder; M Marin-Padilla; A H Sharpe; Nancy A Speck
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3444-9.
1995: A Hajra; P Paul Liu; Nancy A Speck; Francis S Collins
Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.
Molecular and cellular biology 1995;15(9):4980-9.
1995: W Sun; B J Graves; Nancy A Speck
Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins.
Journal of virology 1995;69(8):4941-9.
1995: Ari L Zaiman; A F Lewis; BE Crute; Nancy A Speck; Jack Lenz
Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores.
Journal of virology 1995;69(5):2898-906.
1995: C Wijmenga; Nancy A Speck; N C Dracopoli; M H Hofker; P Liu; Francis S Collins
Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.
Genomics 1995;26(3):611-4.
1995: A Hajra; P Paul Liu; Qingru Wang; C A Kelley; Terryl Stacy; Robert S Adelstein; Nancy A Speck; Francis S Collins
The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1926-30.
1995: Nancy A Speck; S Terryl
A new transcription factor family associated with human leukemias.
Critical reviews in eukaryotic gene expression 1995;5(3-4):337-64.
1994: P Liu; Nancy E Seidel; David M Bodine; Nancy A Speck; S Tarlé; Francis S Collins
Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.
Cold Spring Harbor symposia on quantitative biology 1994;59():547-53.
1993: S Wang; Qingru Wang; BE Crute; I N Melnikova; Susanna R Keller; Nancy A Speck
Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.
Molecular and cellular biology 1993;13(6):3324-39.
1993: I N Melnikova; BE Crute; S Wang; Nancy A Speck
Sequence specificity of the core-binding factor.
Journal of virology 1993;67(4):2408-11.
1993: W Sun; M O'Connell; Nancy A Speck
Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers.
Journal of virology 1993;67(4):1976-86.
1992: S W Wang; Nancy A Speck
Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.
Molecular and cellular biology 1992;12(1):89-102.