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Deborah Spector

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Christopher S Morello; Zhijiang Chen; Kimberly A Kraynyak; Kuo-Fen Lee; Michael S Levinson; Deborah H Spector
Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge.
Sarah W Burgdorf; Charles L Clark; James R Burgdorf; Deborah H Spector
Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.
Christopher S Morello; Michael S Levinson; Kimberly A Kraynyak; Deborah H Spector
Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease.

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2012: Christopher S Morello; Zhijiang Chen; Kimberly A Kraynyak; Kuo-Fen Lee; Michael S Levinson; Deborah H Spector
Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge.
Vaccine 2012;30(46):6541-50.
2011: Sarah W Burgdorf; Charles L Clark; James R Burgdorf; Deborah H Spector
Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.
Journal of virology 2011;85(21):11098-110.
2011: Christopher S Morello; Michael S Levinson; Kimberly A Kraynyak; Deborah H Spector
Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease.
Journal of virology 2011;85(7):3461-72.
2010: Karen Tran; Jeremy P Kamil; Donald M Coen; Deborah H Spector
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
Journal of virology 2010;84(20):10832-43.
2010: Karen Tran; Jeffrey A Mahr; Deborah H Spector
Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription.
Journal of virology 2010;84(6):3079-93.
2009: Anokhi J Kapasi; Charles L Clark; Karen Tran; Deborah H Spector
Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.
Journal of virology 2009;83(11):5904-17.
2008: Rebecca L Sanders; Christia J Del Rosario; Elizabeth A White; Deborah H Spector
Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomes.
Journal of virology 2008;82(22):11383-97.
2008: Rebecca L Sanders; Charles L Clark; Christopher S Morello; Deborah H Spector
Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.
Journal of virology 2008;82(14):7059-77.
2008: Karen Tran; Jeffrey A Mahr; Jiwon Choi; Jose Teodoro; Michael R Green; Deborah H Spector
Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.
Journal of virology 2008;82(1):529-37.
2008: Anokhi J Kapasi; Deborah H Spector
Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome.
Journal of virology 2008;82(1):394-407.
2007: Finn E Grey; Heather Meyers; Elizabeth A White; Deborah H Spector; Jay A Nelson
A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.
PLoS pathogens 2007;3(11):e163.
2007: Veronica Sanchez; Jeffrey A Mahr; Nicole I Orazio; Deborah H Spector
Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter.
Journal of virology 2007;81(21):11730-6.
2007: Christopher S Morello; Laura A Kelley; Michael W Munks; Ann B Hill; Deborah H Spector
DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.
Journal of virology 2007;81(14):7766-75.
2007: Elizabeth A White; Christia J Del Rosario; Rebecca L Sanders; Deborah H Spector
The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.
Journal of virology 2007;81(6):2573-83.
2006: Mark Shlapobersky; Rebecca Sanders; Charles Clark; Deborah H Spector
Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription.
Journal of virology 2006;80(20):9951-61.
2006: Veronica Sanchez; Deborah H Spector
Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles.
Journal of virology 2006;80(12):5886-96.
2006: Michael W Munks; Marielle C Gold; Allison L Zajac; Carmen Doom; Christopher S Morello; Deborah H Spector; Ann B Hill
Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3760-6.
2005: Sama Tamrakar; Anokhi J Kapasi; Deborah H Spector
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Journal of virology 2005;79(24):15477-93.
2005: Elizabeth A White; Deborah H Spector
Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.
Journal of virology 2005;79(12):7438-52.
2005: Christopher S Morello; Ming Ye; Stephanie Hung; Laura A Kelley; Deborah H Spector
Systemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challenge.
Journal of virology 2005;79(1):159-75.
2004: Ming Ye; Christopher S Morello; Deborah H Spector
Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization.
Journal of virology 2004;78(20):11233-45.
2004: Veronica Sanchez; Anita K McElroy; Judy Yen; Sama Tamrakar; Charles L Clark; Rachel A Schwartz; Deborah H Spector
Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production.
Journal of virology 2004;78(20):11219-32.
2004: Elizabeth A White; Charles L Clark; Veronica Sanchez; Deborah H Spector
Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.
Journal of virology 2004;78(4):1817-30.
2003: Veronica Sanchez; Anita K McElroy; Deborah H Spector
Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus.
Journal of virology 2003;77(24):13214-24.
2003: Nilima Biswas; Veronica Sanchez; Deborah H Spector
Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.
Journal of virology 2003;77(4):2369-76.
2003: Elizabeth A Fortunato; Deborah H Spector
Viral induction of site-specific chromosome damage.
Reviews in medical virology 2003;13(1):21-37.
2002: Veronica Sanchez; Deborah H Spector
Virology. CMV makes a timely exit.
Science (New York, N.Y.) 2002;297(5582):778-9.
2002: Elizabeth A Fortunato; Veronica Sanchez; Judy Y Yen; Deborah H Spector
Infection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome.
Journal of virology 2002;76(11):5369-79.
2002: Christopher S Morello; Ming Ye; Deborah H Spector
Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replication.
Journal of virology 2002;76(10):4822-35.
2002: Veronica Sanchez; Charles L Clark; Judy Y Yen; Roopashree Dwarakanath; Deborah H Spector
Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication.
Journal of virology 2002;76(6):2973-89.
2002: Ming Ye; Christopher S Morello; Deborah H Spector
Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challenge.
Journal of virology 2002;76(5):2100-12.
2001: Roopashree Dwarakanath; Charles L Clark; Anita K McElroy; Deborah H Spector
The use of recombinant baculoviruses for sustained expression of human cytomegalovirus immediate early proteins in fibroblasts.
Virology 2001;284(2):297-307.
2000: Anita K McElroy; Roopashree Dwarakanath; Deborah H Spector
Dysregulation of cyclin E gene expression in human cytomegalovirus-infected cells requires viral early gene expression and is associated with changes in the Rb-related protein p130.
Journal of virology 2000;74(9):4192-206.
2000: Christopher S Morello; L D Cranmer; Deborah H Spector
Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65).
Journal of virology 2000;74(8):3696-708.
2000: Elizabeth A Fortunato; Anita K McElroy; I Sanchez; Deborah H Spector
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
Trends in microbiology 2000;8(3):111-9.
2000: Elizabeth A Fortunato; M L Dell'Aquila; Deborah H Spector
Specific chromosome 1 breaks induced by human cytomegalovirus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):853-8.
1999: Christopher S Morello; L D Cranmer; Deborah H Spector
In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83).
Journal of virology 1999;73(9):7678-93.
1999: Elizabeth A Fortunato; Deborah H Spector
Regulation of human cytomegalovirus gene expression.
Advances in virus research 1999;54():61-128.
1998: S M Rodems; Deborah H Spector
Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection.
Journal of virology 1998;72(11):9173-80.
1998: B S Salvant; Elizabeth A Fortunato; Deborah H Spector
Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription.
Journal of virology 1998;72(5):3729-41.
1998: S M Rodems; Charles L Clark; Deborah H Spector
Separate DNA elements containing ATF/CREB and IE86 binding sites differentially regulate the human cytomegalovirus UL112-113 promoter at early and late times in the infection.
Journal of virology 1998;72(4):2697-707.
1998: Elizabeth A Fortunato; Deborah H Spector
p53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus.
Journal of virology 1998;72(3):2033-9.
1997: Karen Hsia; Deborah H Spector; Stephen A Spector
Molecular analysis of the differential restriction of human immunodeficiency virus type 1 replication in neuronal cell lines.
The Journal of general virology 1997;78 ( Pt 12)():3255-64.
1997: Elizabeth A Fortunato; M H Sommer; K Yoder; Deborah H Spector
Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other.
Journal of virology 1997;71(11):8176-85.
1997: T N Moreno; Elizabeth A Fortunato; Karen Hsia; Stephen A Spector; Deborah H Spector
A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells.
Journal of virology 1997;71(5):3693-701.
1996: L D Cranmer; C L Clark; C S Morello; Helen E Farrell; William D Rawlinson; Deborah H Spector
Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins.
Journal of virology 1996;70(11):7929-39.
1996: J C González Armas; C S Morello; L D Cranmer; Deborah H Spector
DNA immunization confers protection against murine cytomegalovirus infection.
Journal of virology 1996;70(11):7921-8.
1996: R Schwartz; Brian Helmich; Deborah H Spector
CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter.
Journal of virology 1996;70(10):6955-66.
1995: F M Jault; Jean-Michel Jault; F Ruchti; Elizabeth A Fortunato; C Clark; Jacques Corbeil; Douglas D Richman; Deborah H Spector
Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest.
Journal of virology 1995;69(11):6697-704.
1995: A L Scully; M H Sommer; R Schwartz; Deborah H Spector
The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations.
Journal of virology 1995;69(10):6533-40.
1995: V Koval; F M Jault; P G Pal; T N Moreno; C Aiken; Didier Trono; Stephen A Spector; Deborah H Spector
Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences.
Journal of virology 1995;69(3):1645-51.
1994: L D Cranmer; C Clark; Deborah H Spector
Cloning, characterization, and expression of the murine cytomegalovirus homologue of the human cytomegalovirus 28-kDa matrix phosphoprotein (UL99).
Virology 1994;205(2):417-29.
1994: E J Wade; Deborah H Spector
The human cytomegalovirus origin of DNA replication (oriLyt) is the critical cis-acting sequence regulating replication-dependent late induction of the viral 1.2-kilobase RNA promoter.
Journal of virology 1994;68(10):6567-77.
1994: M H Sommer; A L Scully; Deborah H Spector
Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein.
Journal of virology 1994;68(10):6223-31.
1994: R Schwartz; M H Sommer; A Scully; Deborah H Spector
Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter.
Journal of virology 1994;68(9):5613-22.
1994: Janet L Lathey; Deborah H Spector; Stephen A Spector
Human cytomegalovirus-mediated enhancement of human immunodeficiency virus type-1 production in monocyte-derived macrophages.
Virology 1994;199(1):98-104.
1994: F M Jault; Stephen A Spector; Deborah H Spector
The effects of cytomegalovirus on human immunodeficiency virus replication in brain-derived cells correlate with permissiveness of the cells for each virus.
Journal of virology 1994;68(2):959-73.
1993: K M Klucher; M Sommer; James T Kadonaga; Deborah H Spector
In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.
Molecular and cellular biology 1993;13(2):1238-50.
1992: E J Wade; K M Klucher; Deborah H Spector
An AP-1 binding site is the predominant cis-acting regulatory element in the 1.2-kilobase early RNA promoter of human cytomegalovirus.
Journal of virology 1992;66(4):2407-17.
1991: V Koval; C Clark; Mahima Vaishnav; Stephen A Spector; Deborah H Spector
Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses.
Journal of virology 1991;65(12):6969-78.
1991: R Elliott; C Clark; D Jaquish; Deborah H Spector
Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene.
Virology 1991;185(1):169-86.
1990: K M Klucher; Deborah H Spector
The human cytomegalovirus 2.7-kilobase RNA promoter contains a functional binding site for the adenovirus major late transcription factor.
Journal of virology 1990;64(9):4189-98.
1990: Deborah H Spector; E Wade; D A Wright; V Koval; C Clark; D Jaquish; Stephen A Spector
Human immunodeficiency virus pseudotypes with expanded cellular and species tropism.
Journal of virology 1990;64(5):2298-308.
1990: Deborah H Spector; K M Klucher; D K Rabert; D A Wright
Human cytomegalovirus early gene expression.
Current topics in microbiology and immunology 1990;154():21-45.
1989: K M Klucher; D K Rabert; Deborah H Spector
Sequences in the human cytomegalovirus 2.7-kilobase RNA promoter which mediate its regulation as an early gene.
Journal of virology 1989;63(12):5334-43.
1989: Karen Hsia; Deborah H Spector; J Lawrie; Stephen A Spector
Enzymatic amplification of human cytomegalovirus sequences by polymerase chain reaction.
Journal of clinical microbiology 1989;27(8):1802-9.
1989: Stephen A Spector; Karen Hsia; F Denaro; Deborah H Spector
Use of molecular probes to detect human cytomegalovirus and human immunodeficiency virus.
Clinical chemistry 1989;35(8):1581-7.
1989: D A Wright; Deborah H Spector
Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit.
Journal of virology 1989;63(7):3117-27.
1988: S I Staprans; D K Rabert; Deborah H Spector
Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene.
Journal of virology 1988;62(9):3463-73.
1988: J A Mercer; C A Wiley; Deborah H Spector
Pathogenesis of murine cytomegalovirus infection: identification of infected cells in the spleen during acute and latent infections.
Journal of virology 1988;62(3):987-97.
1988: J R Marks; Deborah H Spector
Replication of the murine cytomegalovirus genome: structure and role of the termini in the generation and cleavage of concatenates.
Virology 1988;162(1):98-107.
1988: D A Wright; S I Staprans; Deborah H Spector
Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169.
Journal of virology 1988;62(1):331-40.
1986: S I Staprans; Deborah H Spector
2.2-kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169.
Journal of virology 1986;57(2):591-602.
1986: J A Mercer; Deborah H Spector
Pathogenesis of acute murine cytomegalovirus infection in resistant and susceptible strains of mice.
Journal of virology 1986;57(2):497-504.
1985: S B Shaw; R D Rasmussen; S H McDonough; S I Staprans; J P Vacquier; Deborah H Spector
Cell-related sequences in the DNA genome of human cytomegalovirus strain AD169.
Journal of virology 1985;55(3):843-8.
1985: R D Rasmussen; S I Staprans; S B Shaw; Deborah H Spector
Sequences in human cytomegalovirus which hybridize with the avian retrovirus oncogene v-myc are G + C rich and do not hybridize with the human c-myc gene.
Molecular and cellular biology 1985;5(6):1525-30.
1985: S H McDonough; S I Staprans; Deborah H Spector
Analysis of the major transcripts encoded by the long repeat of human cytomegalovirus strain AD169.
Journal of virology 1985;53(3):711-8.
1984: J R Marks; Deborah H Spector
Fusion of the termini of the murine cytomegalovirus genome after infection.
Journal of virology 1984;52(1):24-8.
1983: J R Marks; J A Mercer; Deborah H Spector
Transcription in mouse embryo cells permissively infected by murine cytomegalovirus.
Virology 1983;131(1):247-54.
1983: J A Mercer; J R Marks; Deborah H Spector
Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith Strain).
Virology 1983;129(1):94-106.
1983: Deborah H Spector; J P Vacquier
Human cytomegalovirus (strain AD169) contains sequences related to the avian retrovirus oncogene v-myc.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):3889-93.
1983: S H McDonough; Deborah H Spector
Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169.
Virology 1983;125(1):31-46.